Danio rerio

69 known processes

mlh1

mutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli)

(Aliases: zgc:66301,MGC66301)

mlh1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular macromolecule metabolic processGO:00442603910.435
cellular aromatic compound metabolic processGO:00067252950.324
organelle organizationGO:00069962270.248
nucleic acid metabolic processGO:00903042440.236
regionalizationGO:00030022740.218
rna biosynthetic processGO:00327741810.207
organic cyclic compound metabolic processGO:19013603010.184
nucleobase containing compound metabolic processGO:00061392740.156
chromosome organizationGO:0051276310.146
meiotic cell cycle processGO:190304630.129
nucleobase containing compound biosynthetic processGO:00346542050.127
meiosis iGO:000712710.120
regulation of nucleobase containing compound metabolic processGO:00192192500.111
Mouse
nitrogen compound metabolic processGO:00068073190.110
single organism transportGO:00447652060.108
single organism metabolic processGO:00447102170.099
agingGO:000756820.098
heterocycle metabolic processGO:00464832900.097
signal transductionGO:00071654550.096
Mouse
heterocycle biosynthetic processGO:00181302150.091
negative regulation of cellular processGO:00485232830.091
Mouse
rna metabolic processGO:00160702190.088
Mouse
regulation of nitrogen compound metabolic processGO:00511712510.084
Mouse
cellular biosynthetic processGO:00442492860.081
nucleocytoplasmic transportGO:000691340.080
larval developmentGO:000216420.076
cell surface receptor signaling pathwayGO:00071663250.075
cellular component morphogenesisGO:00329893360.075
regulation of gene expressionGO:00104682650.074
cellular nitrogen compound metabolic processGO:00346412900.073
aromatic compound biosynthetic processGO:00194382170.073
regulation of transcription dna templatedGO:00063552130.072
positive regulation of cell cycleGO:004578730.071
regulation of macromolecule biosynthetic processGO:00105562250.068
organic substance biosynthetic processGO:19015762890.065
single organism organelle organizationGO:19025891990.065
negative regulation of dna recombinationGO:004591020.065
Mouse
regulation of rna metabolic processGO:00512522240.064
regulation of dna recombinationGO:000001820.063
Mouse
nuclear transportGO:005116940.061
cellular nitrogen compound biosynthetic processGO:00442712180.059
regulation of rna biosynthetic processGO:20011412130.059
regulation of cell communicationGO:00106462320.057
positive regulation of biological processGO:00485182530.057
multicellular organism growthGO:003526440.057
cellular macromolecule biosynthetic processGO:00346452240.055
cellular response to dna damage stimulusGO:0006974240.055
Human Yeast Mouse
cell projection morphogenesisGO:00488582440.055
enzyme linked receptor protein signaling pathwayGO:00071671060.053
positive regulation of catabolic processGO:000989640.053
positive regulation of stem cell proliferationGO:200064810.052
regulation of metabolic processGO:00192223590.051
Mouse
cell cycle g2 m phase transitionGO:004483940.050
regulation of cellular metabolic processGO:00313233200.050
Mouse
cell part morphogenesisGO:00329902460.050
lipid storageGO:001991510.050
transcription dna templatedGO:00063511810.049
macromolecule biosynthetic processGO:00090592270.049
regulation of cellular macromolecule biosynthetic processGO:20001122220.049
regulation of nucleic acid templated transcriptionGO:19035062130.048
purine nucleoside monophosphate catabolic processGO:000912840.047
Yeast
regulation of cellular biosynthetic processGO:00313262450.047
telomere organizationGO:003220010.047
programmed cell deathGO:00125011190.047
Mouse
response to uvGO:000941130.046
nucleic acid templated transcriptionGO:00976591810.046
regulation of biosynthetic processGO:00098892500.046
dorsal ventral pattern formationGO:00099531250.045
stem cell divisionGO:001714510.045
negative regulation of biological processGO:00485193040.045
Mouse
embryonic organ morphogenesisGO:00485622740.044
regulation of meiotic cell cycleGO:005144510.044
biosynthetic processGO:00090582940.043
positive regulation of cellular processGO:00485222010.042
nucleoside monophosphate catabolic processGO:000912540.042
Yeast
regulation of primary metabolic processGO:00800903110.041
Mouse
regulation of signal transductionGO:00099662250.041
gastrulationGO:00073692080.041
ribonucleoside monophosphate catabolic processGO:000915840.040
Yeast
maintenance of locationGO:005123540.039
telomere maintenanceGO:000072310.039
cellular amine metabolic processGO:004410620.038
cellular response to stressGO:0033554620.038
Human Yeast Mouse
single organism nuclear importGO:190259330.038
transportGO:00068102200.038
cellular protein metabolic processGO:00442671290.037
regulation of protein transportGO:005122330.037
embryonic heart tube morphogenesisGO:00031431080.037
regulation of cellular amino acid metabolic processGO:000652100.037
response to stressGO:00069502630.037
Human Yeast Mouse
regulation of multicellular organism growthGO:004001440.036
regulation of macromolecule metabolic processGO:00602553170.036
Mouse
protein metabolic processGO:00195381830.036
female sex differentiationGO:004666040.036
single organism localizationGO:19025782250.036
establishment of localizationGO:00512342440.035
amine metabolic processGO:000930820.035
macromolecular complex subunit organizationGO:0043933740.035
Mouse
tube morphogenesisGO:00352393490.034
cell projection organizationGO:00300302840.034
regulation of signalingGO:00230512350.034
immune system processGO:00023762410.034
Mouse
organic cyclic compound biosynthetic processGO:19013622230.033
regulation of establishment of protein localizationGO:007020140.033
hemopoiesisGO:00300971830.033
gene expressionGO:00104672520.033
Mouse
determination of bilateral symmetryGO:00098552040.033
meiotic nuclear divisionGO:000712640.033
response to chemicalGO:00422213200.032
atp catabolic processGO:000620040.032
Yeast
heart morphogenesisGO:00030071560.032
g2 dna damage checkpointGO:003157230.032
protein importGO:001703830.032
brain developmentGO:00074202930.031
transcription from rna polymerase ii promoterGO:0006366800.031
specification of symmetryGO:00097992040.031
cellular localizationGO:0051641970.031
cellular amino acid metabolic processGO:000652070.030
spermatid developmentGO:000728620.030
developmental programmed cell deathGO:001062340.030
establishment of protein localization to organelleGO:007259440.030
intracellular signal transductionGO:0035556850.030
Mouse
regulation of cellular amine metabolic processGO:003323800.029
nuclear importGO:005117030.029
morphogenesis of an epitheliumGO:00020093330.029
regulation of stem cell proliferationGO:007209120.029
regulation of protein localization to nucleusGO:190018020.028
positive regulation of transportGO:005105020.028
regulation of cytoplasmic transportGO:190364940.028
sensory organ developmentGO:00074233930.028
mitotic dna damage checkpointGO:004477340.027
spermatid differentiationGO:004851520.027
stem cell proliferationGO:007208940.027
embryo development ending in birth or egg hatchingGO:00097922710.026
Worm
golgi vesicle transportGO:004819330.026
regulation of response to stimulusGO:00485832690.026
embryonic organ developmentGO:00485683810.026
chromosome organization involved in meiosisGO:007019210.026
positive regulation of cellular component biogenesisGO:004408930.026
regulation of biological qualityGO:00650082630.026
nuclear exportGO:005116810.025
sex determinationGO:000753010.025
microtubule cytoskeleton organization involved in mitosisGO:190285010.025
b cell activationGO:004211320.025
Mouse
cellular response to external stimulusGO:007149620.025
cell cycle processGO:0022402530.025
synapsisGO:000712910.025
macromolecule modificationGO:00434121110.024
golgi organizationGO:000703010.024
neuron differentiationGO:00301823530.024
centrosome duplicationGO:005129810.024
purine ribonucleoside monophosphate catabolic processGO:000916940.024
Yeast
protein import into nucleusGO:000660630.024
development of primary female sexual characteristicsGO:004654540.024
response to drugGO:004249330.023
g2 m transition of mitotic cell cycleGO:000008640.023
regulation of protein targetingGO:190353320.023
regulation of cellular component organizationGO:0051128860.023
cellular response to organic substanceGO:00713101050.023
somatic muscle developmentGO:000752540.023
mitotic dna integrity checkpointGO:004477440.022
regulation of nucleocytoplasmic transportGO:004682220.022
cellular component biogenesisGO:00440851780.022
positive regulation of nitrogen compound metabolic processGO:0051173690.022
anterior posterior pattern specificationGO:00099521520.022
regulation of cytokine productionGO:000181730.022
regulation of cellular ketone metabolic processGO:001056570.022
centrosome organizationGO:005129710.022
determination of heart left right asymmetryGO:00613711170.022
cellular response to radiationGO:007147840.022
cellular protein modification processGO:00064641000.021
organic acid metabolic processGO:0006082310.021
regulation of intracellular protein transportGO:003315730.021
central nervous system developmentGO:00074173870.021
small molecule metabolic processGO:0044281770.021
Yeast
protein localization to nucleusGO:003450430.021
developmental growthGO:00485891660.021
meiotic chromosome segregationGO:004513230.021
embryonic limb morphogenesisGO:003032620.021
heart developmentGO:00075073130.021
proteolysis involved in cellular protein catabolic processGO:005160330.021
apoptotic processGO:00069151160.021
Mouse
organelle fissionGO:0048285230.020
cilium organizationGO:0044782710.020
cellular component assemblyGO:00226071700.020
positive regulation of cellular catabolic processGO:003133130.020
regulation of cell differentiationGO:00455951420.020
spindle assemblyGO:005122520.020
Mouse
reciprocal dna recombinationGO:003582510.020
cell morphogenesisGO:00009022890.020
macromolecular complex disassemblyGO:003298410.020
regulation of protein import into nucleusGO:004230620.020
protein targeting to nucleusGO:004474430.020
regulation of transcription from rna polymerase ii promoterGO:00063571140.019
homeostatic processGO:00425921420.019
regulation of epithelial cell proliferationGO:005067830.019
positive regulation of cellular amine metabolic processGO:003324000.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
ubiquitin dependent protein catabolic processGO:000651130.019
epithelial tube morphogenesisGO:00605621480.019
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.019
cellular component movementGO:00069283350.019
cellular component disassemblyGO:002241110.018
cell morphogenesis involved in differentiationGO:00009041950.018
establishment of localization in cellGO:0051649770.018
skeletal system developmentGO:00015011810.018
double strand break repairGO:000630230.018
Mouse
heart loopingGO:0001947940.018
protein dephosphorylationGO:000647030.018
regulation of protein catabolic processGO:004217610.018
negative regulation of dna metabolic processGO:005105340.018
Mouse
sequestering of calcium ionGO:005120830.018
female gonad developmentGO:000858540.018
positive regulation of dna metabolic processGO:005105410.018
oxoacid metabolic processGO:0043436310.018
organelle assemblyGO:00709251100.018
Mouse
autophagyGO:000691440.018
cell cycleGO:0007049930.018
er to golgi vesicle mediated transportGO:000688810.018
positive regulation of cytokine productionGO:000181920.018
mitotic g2 dna damage checkpointGO:000709530.018
protein complex assemblyGO:0006461300.017
Mouse
regulation of protein complex disassemblyGO:004324410.017
locomotionGO:00400113130.017
segmentationGO:0035282970.017
regulation of protein modification by small protein conjugation or removalGO:190332030.017
positive regulation of cellular metabolic processGO:0031325940.017
internal peptidyl lysine acetylationGO:001839320.017
cilium morphogenesisGO:0060271850.017
proteasomal protein catabolic processGO:001049820.017
modification dependent protein catabolic processGO:001994130.017
digestive system developmentGO:00551232890.017
regulation of cell activationGO:005086510.017
response to radiationGO:0009314510.017
mitotic recombinationGO:000631220.017
Mouse
neuron projection developmentGO:00311751800.017
positive regulation of protein complex assemblyGO:003133420.017
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
pericardium morphogenesisGO:000334410.017
protein modification processGO:00362111000.017
male meiosisGO:000714020.016
gamete generationGO:0007276330.016
regulation of protein complex assemblyGO:004325430.016
mitochondrion organizationGO:000700540.016
regulation of circadian rhythmGO:004275240.016
somatic cell dna recombinationGO:001644410.016
Mouse
cytoskeleton organizationGO:0007010960.016
Mouse
internal protein amino acid acetylationGO:000647520.016
response to light stimulusGO:0009416460.016
carboxylic acid metabolic processGO:0019752220.016
cilium movementGO:0003341260.016
growthGO:00400071740.016
phosphate containing compound metabolic processGO:00067961080.016
Yeast
protein complex disassemblyGO:004324110.016
cellular response to extracellular stimulusGO:003166820.016
spindle assembly involved in mitosisGO:009030710.016
modification dependent macromolecule catabolic processGO:004363230.016
dna biosynthetic processGO:007189730.016
neuron developmentGO:00486662620.015
immune system developmentGO:00025201910.015
Mouse
peptidyl lysine acetylationGO:001839420.015
positive regulation of stress activated mapk cascadeGO:003287430.015
negative regulation of protein phosphorylationGO:000193340.015
determination of left right symmetryGO:00073681790.015
regulation of blood pressureGO:000821710.015
dna metabolic processGO:0006259270.015
intracellular transportGO:0046907320.015
head developmentGO:00603223030.015
hematopoietic stem cell migrationGO:003570140.015
specification of axis polarityGO:006500140.015
cell deathGO:00082191210.015
Mouse
female meiotic divisionGO:000714320.015
tissue remodelingGO:004877140.015
cellular response to starvationGO:000926710.015
rna transportGO:005065820.015
cellular ketone metabolic processGO:0042180110.015
deathGO:00162651210.015
Mouse
positive regulation of jnk cascadeGO:004633030.015
forebrain regionalizationGO:002187140.015
protein polymerizationGO:005125840.015
vasculature developmentGO:00019442780.014
rna 3 end processingGO:003112320.014
Mouse
chemosensory behaviorGO:000763510.014
positive regulation of map kinase activityGO:004340630.014
regulation of cell proliferationGO:0042127370.014
stem cell maintenanceGO:001982740.014
chromatin organizationGO:0006325220.014
adult behaviorGO:003053420.014
cell cycle g1 s phase transitionGO:004484310.014
regulation of multicellular organismal processGO:00512392770.014
dna templated transcription initiationGO:000635210.014
phagocytosisGO:000690930.014
regulation of jak stat cascadeGO:004642530.014
primary neural tube formationGO:001402010.014
somite developmentGO:0061053960.014
striated muscle cell differentiationGO:00511461290.014
negative regulation of nuclear divisionGO:005178430.014
cellular response to nutrient levelsGO:003166920.014
regulation of programmed cell deathGO:00430671010.013
cytokinesisGO:000091030.013
double strand break repair via homologous recombinationGO:000072410.013
regulation of synapse assemblyGO:005196330.013
polarized epithelial cell differentiationGO:003085940.013
positive regulation of cellular biosynthetic processGO:0031328680.013
symbiosis encompassing mutualism through parasitismGO:004440340.013
positive regulation of metabolic processGO:00098931080.013
cellular response to chemical stimulusGO:00708871570.013
septum transversum developmentGO:000334340.013
positive regulation of cytoskeleton organizationGO:005149530.013
response to external biotic stimulusGO:0043207970.013
regulation of localizationGO:00328791040.013
positive regulation of cell activationGO:005086710.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
convergent extensionGO:00600261180.013
positive regulation of nucleobase containing compound metabolic processGO:0045935690.013
positive regulation of rna metabolic processGO:0051254590.013
negative regulation of metabolic processGO:0009892860.013
Mouse
generation of neuronsGO:00486993850.013
positive regulation of signal transductionGO:0009967560.013
myeloid cell differentiationGO:0030099860.013
b cell differentiationGO:003018310.013
g1 s transition of mitotic cell cycleGO:000008210.013
reproductionGO:0000003400.013
tube closureGO:006060610.013
proepicardium developmentGO:000334240.013
positive regulation of macromolecule biosynthetic processGO:0010557590.013
germ line stem cell divisionGO:004207810.013
regulation of anatomical structure sizeGO:0090066330.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
nuclear divisionGO:0000280230.012
neurological system processGO:0050877620.012
axonogenesisGO:00074091520.012
negative regulation of macromolecule metabolic processGO:0010605760.012
Mouse
recombinational repairGO:000072510.012
neuron projection morphogenesisGO:00488121610.012
response to organic substanceGO:00100331530.012
central nervous system neuron differentiationGO:0021953740.012
apoptotic process involved in developmentGO:190274220.012
ribosome assemblyGO:004225510.012
regulation of mesenchymal cell proliferationGO:001046410.012
protein acetylationGO:000647320.012
somitogenesisGO:0001756870.012
protein acylationGO:004354330.012
regulation of bindingGO:005109830.012
chemotaxisGO:00069351040.012
phagocytosis engulfmentGO:000691110.012
immunoglobulin mediated immune responseGO:001606430.012
Mouse
cell agingGO:000756920.012
positive regulation of signalingGO:0023056560.012
angiogenesisGO:00015251580.012
endosomal transportGO:001619720.012
transmembrane transportGO:00550851200.012
positive regulation of cell divisionGO:005178120.012
chordate embryonic developmentGO:00430092710.012
cognitionGO:005089010.012
leukocyte proliferationGO:007066110.012
negative regulation of kinase activityGO:003367340.012
membrane invaginationGO:001032410.012
regulation of blood vessel sizeGO:005088020.012
regulation of protein ubiquitinationGO:003139630.012
immunoglobulin productionGO:000237710.012
Mouse
regulation of apoptotic processGO:0042981980.012
regulation of reactive oxygen species metabolic processGO:200037720.012
rna localizationGO:000640340.011
negative regulation of epithelial cell proliferationGO:005068010.011
microtubule polymerization or depolymerizationGO:003110930.011
cellular protein catabolic processGO:004425740.011
interspecies interaction between organismsGO:004441940.011
neuromuscular synaptic transmissionGO:000727420.011
mesenchymal cell proliferationGO:001046310.011
embryonic heart tube developmentGO:00350501330.011
circadian sleep wake cycle sleepGO:005080210.011
single organism intracellular transportGO:1902582250.011
positive regulation of cell communicationGO:0010647560.011
positive regulation of macromolecule metabolic processGO:0010604930.011
regulation of cell cycle g2 m phase transitionGO:190274940.011
protein homooligomerizationGO:005126030.011
positive regulation of i kappab kinase nf kappab signalingGO:004312330.011
pharyngeal muscle developmentGO:004328240.011
system processGO:00030081850.011
dna templated transcription elongationGO:000635430.011
cellular amide metabolic processGO:004360340.011
regulation of dna templated transcription elongationGO:003278430.011
positive regulation of chromosome organizationGO:200125210.011
axon developmentGO:00615641660.011
response to carbohydrateGO:000974330.011
cell morphogenesis involved in neuron differentiationGO:00486671630.011
peptide transportGO:001583310.011
regulation of reproductive processGO:200024140.011
response to vitaminGO:003327330.011
bmp signaling pathwayGO:0030509520.011
histone h3 k4 methylationGO:005156820.011
mitotic g2 m transition checkpointGO:004481830.011
production of molecular mediator of immune responseGO:000244020.011
Mouse
positive regulation of secretionGO:005104710.011
regulation of stem cell differentiationGO:200073640.010
response to topologically incorrect proteinGO:003596620.010
lamellipodium organizationGO:009758110.010
regulation of translational initiationGO:000644610.010
lipid homeostasisGO:005508830.010
positive regulation of apoptotic signaling pathwayGO:200123510.010
regulation of mitotic cell cycleGO:0007346250.010
regulation of cell cycle processGO:0010564200.010
axon guidanceGO:0007411860.010
nucleic acid transportGO:005065720.010
negative regulation of nitrogen compound metabolic processGO:0051172590.010
Mouse
dna catabolic processGO:000630810.010
negative regulation of multi organism processGO:004390130.010
sequestering of metal ionGO:005123830.010
response to abiotic stimulusGO:00096281220.010
pronephros morphogenesisGO:0072114140.010
protein complex subunit organizationGO:0071822460.010
Mouse
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.010
digestive tract morphogenesisGO:00485462310.010
negative regulation of biosynthetic processGO:0009890550.010
tissue homeostasisGO:0001894250.010
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.010
Mouse

mlh1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
disease of cellular proliferationDOID:1456600.022
cancerDOID:16200.019
organ system cancerDOID:005068600.018
nervous system diseaseDOID:86300.017
immune system diseaseDOID:291400.012
disease of metabolismDOID:001466700.012
inherited metabolic disorderDOID:65500.011