IMP: Integrative Multi-species Prediction

Danio rerio

131 known processes

hdac1

histone deacetylase 1

(Aliases: zgc:101582,wu:fb19h11,wu:fi06f03,mp:zf637-2-001987,zgc:65818,chunp6919,hdac-1,MGC101582)

Ensembl: ENSDARG00000015427
Entrez: 192302
ZFIN: ZDB-GENE-020419-32
UniProtKB: Q8JIY7

Process Predictions
Disease Predictions

hdac1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
central nervous system development	GO:0007417	387	0.971
embryonic organ development	GO:0048568	381	0.900	Worm
larval development	GO:0002164	2	0.862	Worm
camera type eye development	GO:0043010	222	0.796
sensory organ development	GO:0007423	393	0.738
embryonic organ morphogenesis	GO:0048562	274	0.735	Worm
nucleic acid metabolic process	GO:0090304	244	0.672	Human Mouse Worm Fly
regulation of developmental process	GO:0050793	247	0.624
eye development	GO:0001654	277	0.624
cellular component morphogenesis	GO:0032989	336	0.558	Fly
vasculature development	GO:0001944	278	0.520
organic cyclic compound metabolic process	GO:1901360	301	0.510	Human Mouse Worm Fly
epithelial cell differentiation	GO:0030855	116	0.490
retina development in camera type eye	GO:0060041	146	0.490
gene expression	GO:0010467	252	0.456	Human Mouse Worm Fly
organelle organization	GO:0006996	227	0.441	Human Mouse Worm Fly
regulation of multicellular organism growth	GO:0040014	4	0.428
chromatin modification	GO:0016568	21	0.421	Human Mouse Worm Fly
growth	GO:0040007	174	0.408
heterocycle metabolic process	GO:0046483	290	0.370	Human Mouse Worm Fly
neural retina development	GO:0003407	49	0.368
negative regulation of cellular process	GO:0048523	283	0.360
cell morphogenesis	GO:0000902	289	0.338	Fly
generation of neurons	GO:0048699	385	0.338
chordate embryonic development	GO:0043009	271	0.321
glial cell differentiation	GO:0010001	42	0.318
blood vessel morphogenesis	GO:0048514	216	0.311
mitotic g2 dna damage checkpoint	GO:0007095	3	0.294
cell projection organization	GO:0030030	284	0.294	Fly
regulation of growth	GO:0040008	42	0.294
positive regulation of rna metabolic process	GO:0051254	59	0.284	Human Worm
rna biosynthetic process	GO:0032774	181	0.279	Human Mouse Worm Fly
cellular biosynthetic process	GO:0044249	286	0.274	Human Mouse Worm Fly
cellular nitrogen compound metabolic process	GO:0034641	290	0.272	Human Mouse Worm Fly
cellular component assembly	GO:0022607	170	0.271
central nervous system neuron differentiation	GO:0021953	74	0.266
rna metabolic process	GO:0016070	219	0.266	Human Mouse Worm Fly
determination of bilateral symmetry	GO:0009855	204	0.265
biosynthetic process	GO:0009058	294	0.263	Human Mouse Worm Fly
regulation of apoptotic process	GO:0042981	98	0.247	Mouse
regulation of macromolecule metabolic process	GO:0060255	317	0.246	Human Mouse Worm Fly
morphogenesis of an epithelium	GO:0002009	333	0.243
nucleobase containing compound metabolic process	GO:0006139	274	0.238	Human Mouse Worm Fly
striated muscle tissue development	GO:0014706	110	0.237
developmental growth	GO:0048589	166	0.234
hematopoietic or lymphoid organ development	GO:0048534	191	0.221
regulation of gene expression	GO:0010468	265	0.214	Human Mouse Worm Fly
nitrogen compound metabolic process	GO:0006807	319	0.213	Human Mouse Worm Fly
determination of heart left right asymmetry	GO:0061371	117	0.209
regionalization	GO:0003002	274	0.204
camera type eye morphogenesis	GO:0048593	108	0.200
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.200	Human Mouse Worm Fly
dorsal ventral pattern formation	GO:0009953	125	0.196
epithelial tube morphogenesis	GO:0060562	148	0.188
regulation of multicellular organismal development	GO:2000026	223	0.182
organic cyclic compound biosynthetic process	GO:1901362	223	0.176	Human Mouse Worm Fly
inner ear development	GO:0048839	126	0.174
regulation of cell differentiation	GO:0045595	142	0.170
tissue regeneration	GO:0042246	74	0.167
positive regulation of biological process	GO:0048518	253	0.167
cellular component biogenesis	GO:0044085	178	0.164
regeneration	GO:0031099	91	0.161
nucleic acid templated transcription	GO:0097659	181	0.152	Human Mouse Worm Fly
heart morphogenesis	GO:0003007	156	0.152
head development	GO:0060322	303	0.151
single organism organelle organization	GO:1902589	199	0.149	Human Mouse Worm Fly
regulation of mrna processing	GO:0050684	3	0.148
meiotic nuclear division	GO:0007126	4	0.146
regulation of rna metabolic process	GO:0051252	224	0.145	Human Mouse Worm Fly
regulation of cellular biosynthetic process	GO:0031326	245	0.145	Human Mouse Worm Fly
cell part morphogenesis	GO:0032990	246	0.142	Fly
regulation of primary metabolic process	GO:0080090	311	0.140	Human Mouse Worm Fly
protein acetylation	GO:0006473	2	0.139
regulation of cell death	GO:0010941	103	0.136	Mouse
heart development	GO:0007507	313	0.133
positive regulation of metabolic process	GO:0009893	108	0.133	Human Worm
nuclear transport	GO:0051169	4	0.131
tube morphogenesis	GO:0035239	349	0.130	Worm
embryo development ending in birth or egg hatching	GO:0009792	271	0.130
cell projection morphogenesis	GO:0048858	244	0.126	Fly
cell motility	GO:0048870	244	0.122
regulation of nitrogen compound metabolic process	GO:0051171	251	0.121	Human Mouse Worm Fly
stem cell differentiation	GO:0048863	117	0.118
cellular aromatic compound metabolic process	GO:0006725	295	0.116	Human Mouse Worm Fly
neuron development	GO:0048666	262	0.108	Fly
positive regulation of histone modification	GO:0031058	1	0.102
digestive system development	GO:0055123	289	0.102
locomotion	GO:0040011	313	0.102
eye morphogenesis	GO:0048592	144	0.100
cellular protein catabolic process	GO:0044257	4	0.100
organic substance biosynthetic process	GO:1901576	289	0.099	Human Mouse Worm Fly
positive regulation of chromatin modification	GO:1903310	1	0.099
regulation of biological quality	GO:0065008	263	0.098	Human
pigmentation	GO:0043473	85	0.098
cell migration involved in heart development	GO:0060973	22	0.098
transcription from rna polymerase ii promoter	GO:0006366	80	0.096	Human Mouse Worm Fly
establishment of protein localization to organelle	GO:0072594	4	0.095
specification of symmetry	GO:0009799	204	0.095
muscle structure development	GO:0061061	196	0.095	Fly
cellular macromolecule biosynthetic process	GO:0034645	224	0.094	Human Mouse Worm Fly
brain development	GO:0007420	293	0.093
liver development	GO:0001889	96	0.093
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.092	Human Mouse Worm Fly
angiogenesis	GO:0001525	158	0.091
regulation of response to stimulus	GO:0048583	269	0.090	Human Mouse Worm Fly
rna transport	GO:0050658	2	0.090
histone modification	GO:0016570	20	0.088	Human Mouse Worm Fly
negative regulation of rna metabolic process	GO:0051253	48	0.086	Human Mouse Worm Fly
single organism localization	GO:1902578	225	0.085
cell cycle	GO:0007049	93	0.082
apoptotic process	GO:0006915	116	0.082	Mouse Worm
chromatin organization	GO:0006325	22	0.082	Human Mouse Worm Fly
developmental pigmentation	GO:0048066	48	0.081
negative regulation of cellular biosynthetic process	GO:0031327	55	0.079	Human Mouse Worm Fly
chromosome organization	GO:0051276	31	0.079	Human Mouse Worm Fly
death	GO:0016265	121	0.077	Mouse Worm
single organism metabolic process	GO:0044710	217	0.077	Human Mouse Worm Fly
axon development	GO:0061564	166	0.077	Fly
macromolecule modification	GO:0043412	111	0.076	Human Mouse Worm Fly
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.075	Human Mouse Worm Fly
positive regulation of rna biosynthetic process	GO:1902680	57	0.075	Human Worm
cellular macromolecule metabolic process	GO:0044260	391	0.075	Human Mouse Worm Fly
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.074
aromatic compound biosynthetic process	GO:0019438	217	0.074	Human Mouse Worm Fly
positive regulation of cell cycle	GO:0045787	3	0.073
neuron differentiation	GO:0030182	353	0.073	Mouse Fly
aging	GO:0007568	2	0.073	Fly
regulation of cellular component organization	GO:0051128	86	0.071	Fly
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna	GO:0000462	1	0.071
multicellular organism growth	GO:0035264	4	0.070
protein localization to nucleus	GO:0034504	3	0.069
dna metabolic process	GO:0006259	27	0.068	Worm
hepaticobiliary system development	GO:0061008	98	0.068
ribosomal small subunit biogenesis	GO:0042274	2	0.067
regulation of glial cell differentiation	GO:0045685	4	0.066	Mouse
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.065	Human Mouse Worm Fly
regulation of meiotic cell cycle	GO:0051445	1	0.064
rna localization	GO:0006403	4	0.064
protein import into nucleus	GO:0006606	3	0.062
blood vessel development	GO:0001568	246	0.062
segmentation	GO:0035282	97	0.062	Fly
regulation of cell shape	GO:0008360	1	0.061
positive regulation of dna metabolic process	GO:0051054	1	0.061
organelle assembly	GO:0070925	110	0.061
programmed cell death	GO:0012501	119	0.061	Mouse Worm
gland development	GO:0048732	143	0.060
peptidyl lysine acetylation	GO:0018394	2	0.060
negative regulation of biological process	GO:0048519	304	0.059
cellular macromolecular complex assembly	GO:0034622	24	0.059
regulation of rna biosynthetic process	GO:2001141	213	0.059	Human Mouse Worm Fly
ear development	GO:0043583	127	0.058
organic substance transport	GO:0071702	58	0.057
nucleocytoplasmic transport	GO:0006913	4	0.055
establishment of localization	GO:0051234	244	0.055	Worm
developmental growth involved in morphogenesis	GO:0060560	86	0.054
nucleobase containing compound biosynthetic process	GO:0034654	205	0.054	Human Mouse Worm Fly
anatomical structure homeostasis	GO:0060249	36	0.053
embryonic pattern specification	GO:0009880	44	0.053	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.053	Human Worm
astrocyte differentiation	GO:0048708	1	0.052
regulation of nervous system development	GO:0051960	90	0.052
retina morphogenesis in camera type eye	GO:0060042	79	0.052
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.051	Human Worm
positive regulation of notch signaling pathway	GO:0045747	3	0.050
nucleic acid transport	GO:0050657	2	0.049
pigment cell differentiation	GO:0050931	38	0.049
autophagy	GO:0006914	4	0.049
mitotic dna damage checkpoint	GO:0044773	4	0.049
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.048	Human Worm
regulation of signaling	GO:0023051	235	0.048	Human Mouse Worm
cellular protein metabolic process	GO:0044267	129	0.048	Human Mouse Worm Fly
double strand break repair	GO:0006302	3	0.048
negative regulation of chromosome organization	GO:2001251	1	0.047
hemopoiesis	GO:0030097	183	0.047
regulation of nucleic acid templated transcription	GO:1903506	213	0.046	Human Mouse Worm Fly
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.046	Human Worm
cell migration	GO:0016477	237	0.045
positive regulation of biosynthetic process	GO:0009891	68	0.045	Human Worm
muscle tissue development	GO:0060537	110	0.044
embryonic heart tube development	GO:0035050	133	0.044
protein desumoylation	GO:0016926	1	0.043
positive regulation of cellular component biogenesis	GO:0044089	3	0.043
wound healing	GO:0042060	90	0.043
negative regulation of cell differentiation	GO:0045596	46	0.042	Fly
nuclear import	GO:0051170	3	0.041
xanthophore differentiation	GO:0050936	3	0.041
protein import	GO:0017038	3	0.041
cell morphogenesis involved in differentiation	GO:0000904	195	0.041	Fly
positive regulation of developmental process	GO:0051094	50	0.040
notochord development	GO:0030903	54	0.040
rna export from nucleus	GO:0006405	1	0.040
regulation of growth rate	GO:0040009	1	0.040
sensory organ morphogenesis	GO:0090596	200	0.040
negative regulation of biosynthetic process	GO:0009890	55	0.039	Human Mouse Worm Fly
positive regulation of transport	GO:0051050	2	0.038
negative regulation of gene expression	GO:0010629	65	0.038	Human Mouse Worm Fly
protein methylation	GO:0006479	13	0.038
anterior posterior pattern specification	GO:0009952	152	0.037
neuron projection morphogenesis	GO:0048812	161	0.037	Fly
mitotic cell cycle	GO:0000278	64	0.037
maintenance of location	GO:0051235	4	0.036
skin development	GO:0043588	54	0.036	Mouse
biological adhesion	GO:0022610	40	0.036
positive regulation of chromosome organization	GO:2001252	1	0.035
protein acylation	GO:0043543	3	0.035
cell death	GO:0008219	121	0.034	Mouse Worm
oligodendrocyte differentiation	GO:0048709	23	0.034
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.034	Human Mouse Worm Fly
mitotic g2 m transition checkpoint	GO:0044818	3	0.034
cellular protein modification process	GO:0006464	100	0.033	Human Mouse Worm Fly
determination of left right symmetry	GO:0007368	179	0.033
organic substance catabolic process	GO:1901575	28	0.032
meiotic cell cycle process	GO:1903046	3	0.032
midbrain development	GO:0030901	28	0.031
embryonic heart tube morphogenesis	GO:0003143	108	0.031
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.031	Human Worm
heart looping	GO:0001947	94	0.031
anterior posterior axis specification	GO:0009948	20	0.031
covalent chromatin modification	GO:0016569	20	0.031	Human Mouse Worm Fly
epithelial cell development	GO:0002064	42	0.030
cell division	GO:0051301	20	0.029
single organism reproductive process	GO:0044702	40	0.029	Worm
regulation of anatomical structure morphogenesis	GO:0022603	130	0.029	Fly
intrinsic apoptotic signaling pathway by p53 class mediator	GO:0072332	9	0.028
cell differentiation in spinal cord	GO:0021515	40	0.028
positive regulation of cellular process	GO:0048522	201	0.028
skeletal system development	GO:0001501	181	0.028
behavior	GO:0007610	74	0.027
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.027	Human Mouse Worm Fly
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	1	0.027	Human
regulation of mrna splicing via spliceosome	GO:0048024	3	0.026
positive regulation of cell death	GO:0010942	29	0.026
positive regulation of transcription dna templated	GO:0045893	57	0.026	Human Worm
embryonic digestive tract morphogenesis	GO:0048557	3	0.026	Worm
mrna transport	GO:0051028	2	0.026
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.026	Human Mouse Worm Fly
regulation of biosynthetic process	GO:0009889	250	0.026	Human Mouse Worm Fly
immune system process	GO:0002376	241	0.026
negative regulation of cell death	GO:0060548	60	0.026	Mouse
homeostatic process	GO:0042592	142	0.025
protein targeting to nucleus	GO:0044744	3	0.025
regulation of signal transduction	GO:0009966	225	0.025	Human Mouse Worm
histone deacetylation	GO:0016575	2	0.025	Human Mouse Worm Fly
appendage development	GO:0048736	80	0.025	Mouse
retina layer formation	GO:0010842	24	0.025
nucleobase containing compound transport	GO:0015931	2	0.024
establishment of rna localization	GO:0051236	3	0.024
ras protein signal transduction	GO:0007265	7	0.024	Worm
regulation of nucleocytoplasmic transport	GO:0046822	2	0.024
regulation of protein binding	GO:0043393	3	0.024
positive regulation of macromolecule metabolic process	GO:0010604	93	0.024	Human Worm
regulation of gene expression epigenetic	GO:0040029	11	0.023	Worm Fly
mitotic dna integrity checkpoint	GO:0044774	4	0.023
maturation of ssu rrna	GO:0030490	1	0.023
cell proliferation	GO:0008283	80	0.023
signal transduction	GO:0007165	455	0.023
ventral spinal cord interneuron specification	GO:0021521	3	0.022
internal peptidyl lysine acetylation	GO:0018393	2	0.022
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.022
non recombinational repair	GO:0000726	2	0.022
protein modification process	GO:0036211	100	0.022	Human Mouse Worm Fly
neurological system process	GO:0050877	62	0.022
nuclear export	GO:0051168	1	0.022
tongue morphogenesis	GO:0043587	3	0.022	Mouse
protein metabolic process	GO:0019538	183	0.022	Human Mouse Worm Fly
negative regulation of developmental process	GO:0051093	65	0.021	Worm Fly
system process	GO:0003008	185	0.021
renal system development	GO:0072001	94	0.021
regulation of cell communication	GO:0010646	232	0.021	Human Mouse Worm
mesenchyme development	GO:0060485	127	0.021
regulation of cellular metabolic process	GO:0031323	320	0.021	Human Mouse Worm Fly
mrna stabilization	GO:0048255	4	0.020
establishment or maintenance of cell polarity	GO:0007163	29	0.020
stem cell development	GO:0048864	82	0.020
taste bud formation	GO:0061195	3	0.020
stem cell maintenance	GO:0019827	4	0.020
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.019
circulatory system process	GO:0003013	87	0.019
methylation	GO:0032259	22	0.019
activation of mapkkk activity	GO:0000185	1	0.019
regulation of cell development	GO:0060284	100	0.019
transcription elongation from rna polymerase ii promoter	GO:0006368	3	0.019
positive regulation of response to stimulus	GO:0048584	80	0.019
single organism cellular localization	GO:1902580	46	0.019
meiotic chromosome segregation	GO:0045132	3	0.019
regulation of cytoplasmic transport	GO:1903649	4	0.019
rna stabilization	GO:0043489	4	0.019
reproduction	GO:0000003	40	0.019	Worm
cell cycle process	GO:0022402	53	0.019
regulation of neuron differentiation	GO:0045664	56	0.018	Fly
response to stress	GO:0006950	263	0.018
internal protein amino acid acetylation	GO:0006475	2	0.018
stem cell proliferation	GO:0072089	4	0.018
regulation of transcription dna templated	GO:0006355	213	0.018	Human Mouse Worm Fly
positive regulation of cellular metabolic process	GO:0031325	94	0.018	Human Worm
regulation of embryonic development	GO:0045995	47	0.018
retinal pigment epithelium development	GO:0003406	8	0.018
immune system development	GO:0002520	191	0.018
fin regeneration	GO:0031101	51	0.018
transcription dna templated	GO:0006351	181	0.018	Human Mouse Worm Fly
mitotic cell cycle process	GO:1903047	48	0.018
sympathetic nervous system development	GO:0048485	3	0.018
muscle organ development	GO:0007517	101	0.017	Fly
embryonic digestive tract development	GO:0048566	4	0.017	Worm
skeletal muscle tissue development	GO:0007519	67	0.017
cell surface receptor signaling pathway	GO:0007166	325	0.017
embryonic eye morphogenesis	GO:0048048	30	0.017
gliogenesis	GO:0042063	45	0.017
single organism nuclear import	GO:1902593	3	0.017
regulation of histone methylation	GO:0031060	3	0.017
regulation of establishment of protein localization	GO:0070201	4	0.017
cellular component disassembly	GO:0022411	1	0.017
regulation of multicellular organismal process	GO:0051239	277	0.017
cellular macromolecule localization	GO:0070727	21	0.017
regulation of localization	GO:0032879	104	0.017
negative regulation of apoptotic process	GO:0043066	55	0.017	Mouse
spliceosomal complex assembly	GO:0000245	1	0.017
pore complex assembly	GO:0046931	2	0.017
regulation of stem cell proliferation	GO:0072091	2	0.016
negative regulation of macromolecule metabolic process	GO:0010605	76	0.016	Human Mouse Worm Fly
neural tube patterning	GO:0021532	33	0.016
female gamete generation	GO:0007292	14	0.016
macromolecule biosynthetic process	GO:0009059	227	0.016	Human Mouse Worm Fly
embryonic axis specification	GO:0000578	12	0.016
positive regulation of signaling	GO:0023056	56	0.016
tissue remodeling	GO:0048771	4	0.016
connective tissue development	GO:0061448	99	0.016
cell adhesion	GO:0007155	40	0.016
regulation of binding	GO:0051098	3	0.015
interspecies interaction between organisms	GO:0044419	4	0.015	Human
negative regulation of epithelial cell differentiation	GO:0030857	2	0.015
somitogenesis	GO:0001756	87	0.015
neuroblast proliferation	GO:0007405	2	0.015
positive regulation of multicellular organismal process	GO:0051240	52	0.015
regulation of cell proliferation	GO:0042127	37	0.015
regulation of cell cycle	GO:0051726	52	0.014
positive regulation of gene expression	GO:0010628	71	0.014	Human Worm
macromolecule methylation	GO:0043414	19	0.014
post embryonic development	GO:0009791	7	0.014	Worm
regulation of protein transport	GO:0051223	3	0.014
convergent extension	GO:0060026	118	0.014
cell substrate junction assembly	GO:0007044	2	0.014
single organism transport	GO:0044765	206	0.014
regulation of organelle organization	GO:0033043	29	0.014
response to light stimulus	GO:0009416	46	0.014
negative regulation of small gtpase mediated signal transduction	GO:0051058	1	0.014	Worm
regulation of developmental growth	GO:0048638	38	0.014
peripheral nervous system development	GO:0007422	55	0.014
positive regulation of cellular protein metabolic process	GO:0032270	22	0.014
regulation of intracellular protein transport	GO:0033157	3	0.014
negative regulation of ras protein signal transduction	GO:0046580	1	0.014	Worm
response to wounding	GO:0009611	116	0.013
regulation of cellular protein metabolic process	GO:0032268	52	0.013
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.013
regulation of tube size	GO:0035150	2	0.013
establishment of monopolar cell polarity	GO:0061162	2	0.013
regulation of programmed cell death	GO:0043067	101	0.013	Mouse
phosphate containing compound metabolic process	GO:0006796	108	0.013
endodermal cell fate determination	GO:0007493	2	0.013
intracellular transport	GO:0046907	32	0.013
axonogenesis	GO:0007409	152	0.013	Fly
cellular protein localization	GO:0034613	20	0.013
heterocycle biosynthetic process	GO:0018130	215	0.013	Human Mouse Worm Fly
cell cell signaling	GO:0007267	52	0.013
notch signaling pathway	GO:0007219	35	0.013	Worm
regulation of chromatin modification	GO:1903308	5	0.013
3 utr mediated mrna stabilization	GO:0070935	3	0.013
nephron epithelium morphogenesis	GO:0072088	1	0.013
endodermal digestive tract morphogenesis	GO:0061031	2	0.012
negative regulation of cell development	GO:0010721	26	0.012	Fly
macromolecule localization	GO:0033036	54	0.012
hindbrain development	GO:0030902	91	0.012
nuclear pore complex assembly	GO:0051292	2	0.012
cellular localization	GO:0051641	97	0.012
medulla oblongata development	GO:0021550	4	0.012
negative regulation of meiotic cell cycle	GO:0051447	1	0.012
multi organism cellular process	GO:0044764	2	0.012	Human
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.012	Fly
protein polyubiquitination	GO:0000209	4	0.012
epithelial cell morphogenesis	GO:0003382	2	0.012
symbiosis encompassing mutualism through parasitism	GO:0044403	4	0.012	Human
regulation of metabolic process	GO:0019222	359	0.011	Human Mouse Worm Fly
positive regulation of cell development	GO:0010720	25	0.011
intracellular signal transduction	GO:0035556	85	0.011	Mouse Worm
macromolecular complex subunit organization	GO:0043933	74	0.011	Human Mouse Worm Fly
digestive tract development	GO:0048565	265	0.011
regulation of macromolecule biosynthetic process	GO:0010556	225	0.011	Human Mouse Worm Fly
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.011
regulation of phosphate metabolic process	GO:0019220	43	0.011
telomere organization	GO:0032200	1	0.011
response to organic substance	GO:0010033	153	0.011
compound eye development	GO:0048749	2	0.011
epidermis development	GO:0008544	48	0.011	Mouse
central nervous system neuron development	GO:0021954	29	0.011
cartilage development	GO:0051216	96	0.011
positive regulation of cellular amine metabolic process	GO:0033240	0	0.011
photoreceptor cell differentiation	GO:0046530	55	0.011
positive regulation of proteolysis	GO:0045862	10	0.010
cilium morphogenesis	GO:0060271	85	0.010
positive regulation of embryonic development	GO:0040019	3	0.010
taxis	GO:0042330	109	0.010	Fly
regulation of notch signaling pathway	GO:0008593	16	0.010	Worm
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.010

hdac1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.080
nervous system disease	DOID:863	0.024
disease of cellular proliferation	DOID:14566	0.014
cancer	DOID:162	0.014
organ system cancer	DOID:0050686	0.014
musculoskeletal system cancer	DOID:0060100	0.014
physical disorder	DOID:0080015	0.013
developmental disorder of mental health	DOID:0060037	0.011
disease of mental health	DOID:150	0.011
benign neoplasm	DOID:0060072	0.011

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