Danio rerio

81 known processes

fgf19

fibroblast growth factor 19

fgf19 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of multicellular organismal processGO:00512392770.716
macromolecule biosynthetic processGO:00090592270.695
locomotionGO:00400113130.663
positive regulation of cellular processGO:00485222010.630
neuron developmentGO:00486662620.614
regulation of cellular macromolecule biosynthetic processGO:20001122220.607
sensory organ morphogenesisGO:00905962000.544
regulation of metabolic processGO:00192223590.536
regulation of cellular biosynthetic processGO:00313262450.530
nucleic acid metabolic processGO:00903042440.521
cellular component morphogenesisGO:00329893360.515
gene expressionGO:00104672520.481
regulation of rna metabolic processGO:00512522240.465
cellular nitrogen compound metabolic processGO:00346412900.460
nucleobase containing compound biosynthetic processGO:00346542050.450
somite developmentGO:0061053960.437
regulation of developmental processGO:00507932470.427
cellular biosynthetic processGO:00442492860.419
nucleobase containing compound metabolic processGO:00061392740.414
chordate embryonic developmentGO:00430092710.413
signal transductionGO:00071654550.410
cellular aromatic compound metabolic processGO:00067252950.395
cell morphogenesisGO:00009022890.394
biosynthetic processGO:00090582940.391
head developmentGO:00603223030.387
cellular macromolecule metabolic processGO:00442603910.379
growthGO:00400071740.369
negative regulation of metabolic processGO:0009892860.358
regulation of transcription dna templatedGO:00063552130.342
neuron differentiationGO:00301823530.340
aromatic compound biosynthetic processGO:00194382170.317
cellular macromolecule biosynthetic processGO:00346452240.315
regulation of macromolecule metabolic processGO:00602553170.315
regulation of nitrogen compound metabolic processGO:00511712510.314
organic cyclic compound metabolic processGO:19013603010.313
organic cyclic compound biosynthetic processGO:19013622230.309
heterocycle metabolic processGO:00464832900.304
negative regulation of gene expressionGO:0010629650.292
eye developmentGO:00016542770.292
heterocycle biosynthetic processGO:00181302150.283
organic substance biosynthetic processGO:19015762890.279
phagocytosisGO:000690930.279
regulation of gene expressionGO:00104682650.278
negative regulation of cellular processGO:00485232830.274
sensory organ developmentGO:00074233930.272
epithelial tube morphogenesisGO:00605621480.266
ear morphogenesisGO:0042471640.262
regulation of multicellular organismal developmentGO:20000262230.258
morphogenesis of an epitheliumGO:00020093330.257
larval developmentGO:000216420.254
negative regulation of cellular biosynthetic processGO:0031327550.250
cellular nitrogen compound biosynthetic processGO:00442712180.245
rna biosynthetic processGO:00327741810.240
regulation of nucleobase containing compound metabolic processGO:00192192500.239
brain developmentGO:00074202930.236
negative regulation of transcription dna templatedGO:0045892450.220
somitogenesisGO:0001756870.211
generation of neuronsGO:00486993850.204
forebrain generation of neuronsGO:0021872140.201
agingGO:000756820.200
regulation of macromolecule biosynthetic processGO:00105562250.200
cellular response to external stimulusGO:007149620.198
embryonic organ developmentGO:00485683810.194
transcription dna templatedGO:00063511810.194
regulation of transcription from rna polymerase ii promoterGO:00063571140.190
negative regulation of macromolecule biosynthetic processGO:0010558480.187
embryo development ending in birth or egg hatchingGO:00097922710.184
photoreceptor cell differentiationGO:0046530550.182
protein localization to nucleusGO:003450430.178
cellular component movementGO:00069283350.173
negative regulation of nucleic acid templated transcriptionGO:1903507450.172
embryonic organ morphogenesisGO:00485622740.168
epithelial cell differentiationGO:00308551160.168
anterior posterior pattern specificationGO:00099521520.164
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.156
regulation of biosynthetic processGO:00098892500.155
positive regulation of nitrogen compound metabolic processGO:0051173690.155
negative regulation of nitrogen compound metabolic processGO:0051172590.152
cell motilityGO:00488702440.152
nucleic acid templated transcriptionGO:00976591810.149
nitrogen compound metabolic processGO:00068073190.144
negative regulation of biosynthetic processGO:0009890550.140
specification of organ identityGO:001009220.138
regulation of primary metabolic processGO:00800903110.138
regionalizationGO:00030022740.136
negative regulation of nucleobase containing compound metabolic processGO:0045934590.136
negative regulation of rna biosynthetic processGO:1902679450.135
retina morphogenesis in camera type eyeGO:0060042790.134
single organism transportGO:00447652060.134
small molecule metabolic processGO:0044281770.134
vasculature developmentGO:00019442780.133
negative regulation of biological processGO:00485193040.132
response to abiotic stimulusGO:00096281220.131
retina development in camera type eyeGO:00600411460.131
regulation of cellular metabolic processGO:00313233200.129
positive regulation of biosynthetic processGO:0009891680.128
regulation of extrinsic apoptotic signaling pathwayGO:200123630.124
regulation of cell developmentGO:00602841000.120
catecholamine metabolic processGO:000658420.118
leukocyte differentiationGO:0002521250.117
regulation of reproductive processGO:200024140.116
regulation of response to stimulusGO:00485832690.115
positive regulation of biological processGO:00485182530.114
positive regulation of multicellular organismal processGO:0051240520.113
tube morphogenesisGO:00352393490.108
eye morphogenesisGO:00485921440.106
mesenchyme developmentGO:00604851270.103
developmental growthGO:00485891660.103
heart contractionGO:0060047710.101
rna metabolic processGO:00160702190.099
central nervous system developmentGO:00074173870.098
regulation of circadian rhythmGO:004275240.098
regulation of sequestering of calcium ionGO:005128240.097
ear developmentGO:00435831270.096
transcription from rna polymerase ii promoterGO:0006366800.096
forebrain neuron developmentGO:002188470.096
muscle structure developmentGO:00610611960.095
regulation of stem cell differentiationGO:200073640.094
maintenance of locationGO:005123540.092
mesenchymal cell developmentGO:0014031780.092
neural tube patterningGO:0021532330.092
chemosensory behaviorGO:000763510.092
regulation of programmed cell deathGO:00430671010.091
skin developmentGO:0043588540.090
positive regulation of cellular catabolic processGO:003133130.089
neuron projection developmentGO:00311751800.089
glial cell migrationGO:000834730.088
camera type eye morphogenesisGO:00485931080.088
cell proliferationGO:0008283800.085
sequestering of metal ionGO:005123830.084
regulation of cell communicationGO:00106462320.084
system processGO:00030081850.083
cell part morphogenesisGO:00329902460.083
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.082
negative regulation of cellular metabolic processGO:0031324770.082
regulation of cell differentiationGO:00455951420.081
stem cell differentiationGO:00488631170.079
regulation of nervous system developmentGO:0051960900.078
angiogenesisGO:00015251580.078
compound eye developmentGO:004874920.077
regulation of apoptotic processGO:0042981980.076
regulation of developmental growthGO:0048638380.074
segmentationGO:0035282970.073
protein metabolic processGO:00195381830.073
cell projection organizationGO:00300302840.072
regulation of signal transductionGO:00099662250.070
tissue remodelingGO:004877140.070
embryonic heart tube morphogenesisGO:00031431080.069
camera type eye photoreceptor cell differentiationGO:0060219190.069
regulation of nucleic acid templated transcriptionGO:19035062130.068
cell fate specificationGO:0001708680.067
phagocytosis engulfmentGO:000691110.067
hemopoiesisGO:00300971830.066
regulation of organ morphogenesisGO:2000027350.066
negative regulation of sequestering of calcium ionGO:005128340.065
mechanoreceptor differentiationGO:0042490370.065
regulation of anatomical structure morphogenesisGO:00226031300.065
stem cell maintenanceGO:001982740.065
single organism localizationGO:19025782250.064
mesenchymal cell differentiationGO:0048762870.062
positive regulation of canonical wnt signaling pathwayGO:009026340.061
forebrain neuron differentiationGO:0021879140.061
localization of cellGO:00516742440.059
regulation of rna biosynthetic processGO:20011412130.059
blood vessel morphogenesisGO:00485142160.059
response to chemicalGO:00422213200.058
auditory receptor cell fate commitmentGO:000991240.057
response to external stimulusGO:00096052640.057
negative regulation of macromolecule metabolic processGO:0010605760.057
digestive tract morphogenesisGO:00485462310.056
apoptotic processGO:00069151160.056
inner ear receptor cell fate commitmentGO:006012040.056
cell growthGO:0016049570.055
nerve developmentGO:0021675450.055
axonogenesisGO:00074091520.054
photoreceptor cell fate specificationGO:004370410.054
behaviorGO:0007610740.053
cellular amine metabolic processGO:004410620.053
epidermal cell differentiationGO:0009913360.053
inner ear receptor cell differentiationGO:0060113290.053
cranial nerve developmentGO:0021545420.053
amine metabolic processGO:000930820.052
regulation of neurogenesisGO:0050767870.051
blood circulationGO:0008015870.051
cell deathGO:00082191210.051
positive regulation of catabolic processGO:000989640.051
skeletal muscle organ developmentGO:0060538780.050
ameboidal type cell migrationGO:00016671430.050
dorsal ventral pattern formationGO:00099531250.050
gland developmentGO:00487321430.050
inner ear developmentGO:00488391260.050
positive regulation of epithelial cell migrationGO:001063420.050
skeletal system developmentGO:00015011810.050
cellular component assembly involved in morphogenesisGO:00109271070.050
muscle organ developmentGO:00075171010.047
digestive tract developmentGO:00485652650.047
deathGO:00162651210.047
nephron developmentGO:0072006310.047
cell surface receptor signaling pathwayGO:00071663250.046
auditory receptor cell differentiationGO:0042491150.045
single organism metabolic processGO:00447102170.045
central nervous system neuron developmentGO:0021954290.044
muscle cell differentiationGO:00426921390.044
programmed cell deathGO:00125011190.043
positive regulation of neural precursor cell proliferationGO:200017910.042
heart processGO:0003015710.042
negative regulation of multicellular organismal processGO:0051241690.042
sequestering of calcium ionGO:005120830.042
positive regulation of nucleobase containing compound metabolic processGO:0045935690.041
response to stressGO:00069502630.041
neuron projection extensionGO:1990138450.041
developmental cell growthGO:0048588520.041
urogenital system developmentGO:0001655970.041
striated muscle cell differentiationGO:00511461290.041
regulation of catalytic activityGO:0050790550.041
negative regulation of rna metabolic processGO:0051253480.041
positive regulation of stem cell proliferationGO:200064810.040
optomotor responseGO:007163210.040
lens development in camera type eyeGO:0002088220.040
cellular component assemblyGO:00226071700.040
heart developmentGO:00075073130.040
inner ear morphogenesisGO:0042472630.040
oxoacid metabolic processGO:0043436310.039
multicellular organismal response to stressGO:003355520.039
regulation of metal ion transportGO:001095940.039
positive regulation of cellular biosynthetic processGO:0031328680.038
neural retina developmentGO:0003407490.038
regulation of localizationGO:00328791040.038
hematopoietic or lymphoid organ developmentGO:00485341910.037
regulation of cell deathGO:00109411030.037
adult behaviorGO:003053420.037
regulation of axonogenesisGO:0050770320.037
regulation of cellular component movementGO:0051270550.037
positive regulation of nervous system developmentGO:0051962250.037
epidermis developmentGO:0008544480.037
regulation of signalingGO:00230512350.037
axon developmentGO:00615641660.036
regulation of cellular amine metabolic processGO:003323800.036
establishment of protein localization to organelleGO:007259440.036
regulation of cell motilityGO:2000145460.036
positive regulation of developmental processGO:0051094500.035
single organism biosynthetic processGO:0044711710.035
cartilage developmentGO:0051216960.035
immune system processGO:00023762410.035
negative regulation of programmed cell deathGO:0043069580.035
photoreceptor cell fate commitmentGO:004655210.035
neuron projection morphogenesisGO:00488121610.035
response to endogenous stimulusGO:0009719830.034
positive regulation of cell activationGO:005086710.034
otic vesicle developmentGO:0071599420.034
regulation of cell proliferationGO:0042127370.034
regulation of neural precursor cell proliferationGO:200017730.034
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.034
regulation of growthGO:0040008420.034
negative regulation of cell deathGO:0060548600.034
neuron fate commitmentGO:0048663260.033
heart loopingGO:0001947940.033
camera type eye developmentGO:00430102220.033
olfactory placode developmentGO:0071698120.033
organelle assemblyGO:00709251100.032
positive regulation of metabolic processGO:00098931080.032
cellular ketone metabolic processGO:0042180110.032
peripheral nervous system developmentGO:0007422550.032
regulation of cell migrationGO:0030334400.032
stem cell developmentGO:0048864820.032
organonitrogen compound metabolic processGO:1901564740.032
cognitionGO:005089010.031
regulation of neuron differentiationGO:0045664560.031
establishment of localizationGO:00512342440.031
response to woundingGO:00096111160.031
neural crest cell differentiationGO:0014033720.030
midbrain hindbrain boundary developmentGO:0030917230.030
stem cell proliferationGO:007208940.030
actin filament based processGO:0030029640.030
positive regulation of blood circulationGO:190352420.030
pectoral fin developmentGO:0033339500.029
signal transduction in absence of ligandGO:003803410.029
otic vesicle morphogenesisGO:0071600340.029
transportGO:00068102200.029
outflow tract morphogenesisGO:000315110.028
olfactory lobe developmentGO:002198840.028
lipid biosynthetic processGO:0008610220.028
central nervous system neuron differentiationGO:0021953740.028
somatic stem cell maintenanceGO:003501910.028
forebrain cell migrationGO:002188510.028
cilium organizationGO:0044782710.028
regulation of cell morphogenesis involved in differentiationGO:0010769380.028
regulation of nucleotide catabolic processGO:003081120.028
negative regulation of stem cell differentiationGO:200073720.028
regulation of multicellular organism growthGO:004001440.027
positive regulation of cellular metabolic processGO:0031325940.027
regulation of cellular component organizationGO:0051128860.027
circulatory system processGO:0003013870.027
organic acid metabolic processGO:0006082310.027
regulation of mechanoreceptor differentiationGO:004563110.026
lipid metabolic processGO:0006629520.026
negative regulation of gliogenesisGO:001401410.026
forebrain neuron fate commitmentGO:002187710.026
embryonic camera type eye developmentGO:0031076290.026
extrinsic apoptotic signaling pathwayGO:009719130.026
rostrocaudal neural tube patterningGO:0021903290.026
formation of primary germ layerGO:0001704620.026
organelle fissionGO:0048285230.025
regulation of stem cell proliferationGO:007209120.025
positive regulation of cellular amine metabolic processGO:003324000.025
regulation of cell activationGO:005086510.025
nephron morphogenesisGO:007202820.025
neuron migrationGO:0001764220.025
response to nutrientGO:000758430.025
immune system developmentGO:00025201910.025
regulation of neuron projection developmentGO:0010975400.025
glial cell differentiationGO:0010001420.025
muscle cell developmentGO:00550011150.025
cell type specific apoptotic processGO:0097285220.024
regulation of intracellular signal transductionGO:1902531570.024
olfactory bulb developmentGO:002177240.024
negative regulation of protein kinase activityGO:000646940.024
regulation of gtpase activityGO:004308720.024
neural tube developmentGO:0021915620.024
septum transversum developmentGO:000334340.024
regulation of cell migration involved in sprouting angiogenesisGO:009004930.024
gabaergic neuron differentiationGO:009715420.023
muscle tissue developmentGO:00605371100.023
microtubule based processGO:0007017600.023
multi organism processGO:00517041340.023
developmental growth involved in morphogenesisGO:0060560860.023
endoderm developmentGO:0007492490.023
taxisGO:00423301090.023
regulation of cellular amino acid metabolic processGO:000652100.023
cellular response to extracellular stimulusGO:003166820.023
atrial ventricular junction remodelingGO:000329420.023
meiotic nuclear divisionGO:000712640.023
multicellular organism growthGO:003526440.023
positive regulation of transportGO:005105020.023
positive regulation of cell proliferationGO:0008284150.023
nephron epithelium morphogenesisGO:007208810.022
cell morphogenesis involved in differentiationGO:00009041950.022
positive regulation of gene expressionGO:0010628710.022
cell morphogenesis involved in neuron differentiationGO:00486671630.022
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.022
water homeostasisGO:003010440.022
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.022
regulation of epithelial cell proliferationGO:005067830.022
cell projection morphogenesisGO:00488582440.022
regulation of cell shapeGO:000836010.022
positive regulation of response to stimulusGO:0048584800.022
cell migrationGO:00164772370.022
cellular response to hypoxiaGO:007145610.021
extracellular structure organizationGO:0043062270.021
organ formationGO:0048645170.021
embryonic camera type eye morphogenesisGO:0048596190.021
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.021
negative regulation of nuclear divisionGO:005178430.021
response to organic substanceGO:00100331530.021
regulation of blood vessel sizeGO:005088020.021
midbrain developmentGO:0030901280.021
single organism organelle organizationGO:19025891990.021
regulation of cell substrate adhesionGO:001081010.021
positive regulation of epithelial cell proliferationGO:005067910.021
forebrain developmentGO:0030900960.021
connective tissue developmentGO:0061448990.020
specification of symmetryGO:00097992040.020
central nervous system neuron axonogenesisGO:0021955180.020
organelle organizationGO:00069962270.020
cellular amino acid metabolic processGO:000652070.020
embryonic eye morphogenesisGO:0048048300.020
carboxylic acid metabolic processGO:0019752220.020
gastrulationGO:00073692080.020
regulation of organ growthGO:004662030.020
negative regulation of dna replicationGO:000815620.020
embryonic skeletal system developmentGO:0048706970.020
positive regulation of catalytic activityGO:0043085250.020
positive regulation of muscle organ developmentGO:004863610.020
nuclear importGO:005117030.020
visual perceptionGO:0007601170.019
regulation of calcium ion transportGO:005192420.019
positive regulation of macromolecule biosynthetic processGO:0010557590.019
membrane invaginationGO:001032410.019
regenerationGO:0031099910.019
epidermal cell fate specificationGO:000995740.019
negative regulation of developmental processGO:0051093650.019
retina layer formationGO:0010842240.019
negative regulation of apoptotic processGO:0043066550.019
regulation of blood circulationGO:1903522320.019
epithelial cell fate commitmentGO:0072148110.019
response to decreased oxygen levelsGO:0036293250.019
regulation of phosphorus metabolic processGO:0051174430.019
cytoskeleton organizationGO:0007010960.019
positive regulation of tyrosine phosphorylation of stat proteinGO:004253110.019
axial mesoderm developmentGO:0048318100.019
regulation of purine nucleotide catabolic processGO:003312120.018
neuron deathGO:0070997210.018
central nervous system myelinationGO:002201020.018
positive regulation of transcription dna templatedGO:0045893570.018
gtp metabolic processGO:004603940.018
cellular amino acid biosynthetic processGO:000865220.018
guanosine containing compound metabolic processGO:190106840.018
regulation of biological qualityGO:00650082630.018
response to lipidGO:0033993600.018
phosphate containing compound metabolic processGO:00067961080.018
mesoderm morphogenesisGO:0048332510.018
neural crest cell developmentGO:0014032620.018
negative regulation of cell communicationGO:0010648960.018
negative regulation of dna metabolic processGO:005105340.018
determination of left right symmetryGO:00073681790.017
negative regulation of protein phosphorylationGO:000193340.017
regulation of peptidyl tyrosine phosphorylationGO:005073010.017
gliogenesisGO:0042063450.017
regulation of gtp catabolic processGO:003312420.017
regulation of heart contractionGO:0008016320.017
positive regulation of macromolecule metabolic processGO:0010604930.017
cellular response to oxygen levelsGO:007145310.017
protein importGO:001703830.017
guanosine containing compound catabolic processGO:190106920.017
positive regulation of striated muscle tissue developmentGO:004584410.016
semicircular canal developmentGO:0060872240.016
extracellular matrix organizationGO:0030198270.016
cilium morphogenesisGO:0060271850.016
striated muscle tissue developmentGO:00147061100.016
nuclear transportGO:005116940.016
modification dependent protein catabolic processGO:001994130.016
cellular amide metabolic processGO:004360340.016
cellular component disassemblyGO:002241110.016
regulation of cellular ketone metabolic processGO:001056570.016
microtubule organizing center organizationGO:003102310.016
positive regulation of nucleoside metabolic processGO:004597910.016
tube formationGO:0035148250.016
cellular cation homeostasisGO:0030003170.016
regulation of wnt signaling pathwayGO:0030111530.016
production of molecular mediator of immune responseGO:000244020.016
axon ensheathment in central nervous systemGO:003229120.016
paraxial mesoderm developmentGO:004833980.016
regulation of canonical wnt signaling pathwayGO:0060828340.016
positive regulation of cell cycleGO:004578730.016
proteolysis involved in cellular protein catabolic processGO:005160330.015
embryonic cranial skeleton morphogenesisGO:0048701900.015
renal tubule morphogenesisGO:006133310.015
cranial ganglion developmentGO:006155030.015
developmental maturationGO:0021700340.015
neurological system processGO:0050877620.015
single organism cellular localizationGO:1902580460.015
intracellular signal transductionGO:0035556850.015
sprouting angiogenesisGO:0002040530.015
positive regulation of cellular component biogenesisGO:004408930.015
determination of bilateral symmetryGO:00098552040.015
protein modification processGO:00362111000.015
response to hypoxiaGO:0001666250.015
cell substrate adhesionGO:003158940.015
regulation of cell growthGO:0001558290.015
negative regulation of gastrulationGO:2000542110.015
regulation of production of molecular mediator of immune responseGO:000270010.015
embryonic digestive tract developmentGO:004856640.015
regulation of growth rateGO:004000910.015
positive regulation of map kinase activityGO:004340630.015
cell proliferation in forebrainGO:002184630.015
positive regulation of dna metabolic processGO:005105410.015
response to vitaminGO:003327330.015
b cell activationGO:004211320.015
macromolecule modificationGO:00434121110.014
semicircular canal morphogenesisGO:0048752180.014
response to organic cyclic compoundGO:0014070510.014
regulation of axon guidanceGO:190266780.014
retinal rod cell developmentGO:004654840.014
cytosolic calcium ion transportGO:006040130.014
positive regulation of gtpase activityGO:004354710.014
regulation of rho protein signal transductionGO:003502320.014
kidney epithelium developmentGO:0072073230.014
appendage morphogenesisGO:0035107560.014
mesoderm developmentGO:0007498880.014
reproductive processGO:0022414400.014
positive regulation of apoptotic signaling pathwayGO:200123510.014
single organism nuclear importGO:190259330.014
release of sequestered calcium ion into cytosolGO:005120930.014
cell matrix adhesionGO:000716040.014
gtp catabolic processGO:000618420.014
cell adhesionGO:0007155400.014
pronephric duct developmentGO:0039022130.014
diencephalon developmentGO:0021536580.014
dopamine biosynthetic processGO:004241620.014
notch signaling pathwayGO:0007219350.014
protein import into nucleusGO:000660630.014
phosphorus metabolic processGO:00067931090.014
positive regulation of molecular functionGO:0044093330.014
developmental programmed cell deathGO:001062340.014
cellular response to chemical stimulusGO:00708871570.014
regulation of immune system processGO:0002682340.014
canonical wnt signaling pathwayGO:0060070480.013
catechol containing compound biosynthetic processGO:000971320.013
positive regulation of hydrolase activityGO:0051345130.013
cellular homeostasisGO:0019725260.013
auditory receptor cell fate determinationGO:004266820.013
positive regulation of purine nucleotide catabolic processGO:003312310.013
optokinetic behaviorGO:000763490.013
regulation of reactive oxygen species metabolic processGO:200037720.013
positive regulation of cytosolic calcium ion concentrationGO:000720440.013
renal system developmentGO:0072001940.013

fgf19 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.074
disease of metabolismDOID:001466700.022
musculoskeletal system diseaseDOID:1700.017