Danio rerio

0 known processes

slc9a8

solute carrier family 9 (sodium/hydrogen exchanger), member 8

(Aliases: wu:fj61b02,zgc:103660,nhe8)

slc9a8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
establishment of protein localization to organelleGO:007259440.172
response to organic substanceGO:00100331530.170
response to transition metal nanoparticleGO:1990267280.160
regulation of metabolic processGO:00192223590.157
single organism localizationGO:19025782250.134
protein localization to nucleusGO:003450430.122
single organism transportGO:00447652060.120
signal transductionGO:00071654550.107
larval developmentGO:000216420.093
sensory organ developmentGO:00074233930.091
nucleocytoplasmic transportGO:000691340.085
regulation of biological qualityGO:00650082630.085
regulation of cell communicationGO:00106462320.082
regulation of cellular metabolic processGO:00313233200.081
single organism nuclear importGO:190259330.081
establishment of localization in cellGO:0051649770.079
cell surface receptor signaling pathwayGO:00071663250.077
eye developmentGO:00016542770.077
nuclear transportGO:005116940.077
agingGO:000756820.077
protein targeting to nucleusGO:004474430.075
organelle organizationGO:00069962270.074
macromolecule biosynthetic processGO:00090592270.073
cellular macromolecule metabolic processGO:00442603910.072
establishment of localizationGO:00512342440.071
heterocycle biosynthetic processGO:00181302150.070
regulation of protein transportGO:005122330.067
positive regulation of i kappab kinase nf kappab signalingGO:004312330.065
regulation of signalingGO:00230512350.065
nuclear importGO:005117030.064
regulation of macromolecule metabolic processGO:00602553170.061
regulation of gene expressionGO:00104682650.058
regulation of response to oxidative stressGO:190288220.058
protein importGO:001703830.057
response to stressGO:00069502630.056
hindbrain developmentGO:0030902910.055
central nervous system developmentGO:00074173870.055
response to glucocorticoidGO:005138410.055
gene expressionGO:00104672520.054
regulation of multicellular organism growthGO:004001440.053
response to drugGO:004249330.053
protein import into nucleusGO:000660630.052
cellular biosynthetic processGO:00442492860.052
regulation of reactive oxygen species metabolic processGO:200037720.052
regulation of protein localization to nucleusGO:190018020.052
cellular macromolecule biosynthetic processGO:00346452240.051
oxoacid metabolic processGO:0043436310.051
cognitionGO:005089010.050
regulation of primary metabolic processGO:00800903110.050
regulation of nucleocytoplasmic transportGO:004682220.050
regulation of signal transductionGO:00099662250.049
regulation of response to stimulusGO:00485832690.048
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.047
response to vitaminGO:003327330.047
multicellular organism growthGO:003526440.047
cellular nitrogen compound metabolic processGO:00346412900.047
organic substance biosynthetic processGO:19015762890.046
small molecule metabolic processGO:0044281770.046
reactive oxygen species biosynthetic processGO:190340910.045
protein metabolic processGO:00195381830.045
response to chemicalGO:00422213200.044
homeostatic processGO:00425921420.044
regulation of nucleobase containing compound metabolic processGO:00192192500.044
regulation of biosynthetic processGO:00098892500.044
amine metabolic processGO:000930820.043
organic substance transportGO:0071702580.043
cellular lipid catabolic processGO:004424230.043
negative regulation of biological processGO:00485193040.043
regulation of protein import into nucleusGO:004230620.043
tube morphogenesisGO:00352393490.043
single organism organelle organizationGO:19025891990.042
camera type eye developmentGO:00430102220.042
regulation of transcription dna templatedGO:00063552130.042
cell death in response to oxidative stressGO:003647320.042
lipid storageGO:001991510.042
modification dependent macromolecule catabolic processGO:004363230.041
response to nutrientGO:000758430.041
regulation of tube sizeGO:003515020.041
organelle fusionGO:004828430.040
regulation of cellular ketone metabolic processGO:001056570.040
g protein coupled receptor signaling pathwayGO:0007186740.040
biosynthetic processGO:00090582940.040
cellular response to external stimulusGO:007149620.039
maintenance of locationGO:005123540.038
cellular ketone metabolic processGO:0042180110.038
response to abiotic stimulusGO:00096281220.037
regulation of developmental processGO:00507932470.037
negative regulation of cellular processGO:00485232830.036
regulation of fatty acid metabolic processGO:001921710.036
proteolysis involved in cellular protein catabolic processGO:005160330.036
rna metabolic processGO:00160702190.036
organonitrogen compound metabolic processGO:1901564740.035
nucleobase containing compound metabolic processGO:00061392740.035
protein secretionGO:000930610.035
response to corticosteroidGO:003196010.035
cellular nitrogen compound biosynthetic processGO:00442712180.034
i kappab kinase nf kappab signalingGO:000724940.034
organic cyclic compound biosynthetic processGO:19013622230.034
regulation of cellular macromolecule biosynthetic processGO:20001122220.033
regionalizationGO:00030022740.033
embryonic organ developmentGO:00485683810.032
neuron neuron synaptic transmissionGO:000727010.032
regulation of intracellular protein transportGO:003315730.032
regulation of cellular amino acid metabolic processGO:000652100.032
cellular amine metabolic processGO:004410620.031
regulation of cytokine productionGO:000181730.031
negative regulation of intrinsic apoptotic signaling pathwayGO:200124380.031
positive regulation of transportGO:005105020.031
organic acid metabolic processGO:0006082310.031
regulation of transcription from rna polymerase ii promoterGO:00063571140.031
generation of neuronsGO:00486993850.031
regulation of cellular amine metabolic processGO:003323800.031
rna biosynthetic processGO:00327741810.031
transportGO:00068102200.031
stem cell proliferationGO:007208940.030
regulation of protein targetingGO:190353320.030
lipid catabolic processGO:001604240.030
positive regulation of blood circulationGO:190352420.030
positive regulation of cellular catabolic processGO:003133130.030
hydrogen peroxide metabolic processGO:004274320.030
erk1 and erk2 cascadeGO:007037140.030
response to hormoneGO:0009725480.030
cellular response to chemical stimulusGO:00708871570.030
ubiquitin dependent protein catabolic processGO:000651130.030
single organism metabolic processGO:00447102170.029
nucleic acid templated transcriptionGO:00976591810.029
cellular response to extracellular stimulusGO:003166820.029
regulation of macromolecule biosynthetic processGO:00105562250.029
positive regulation of metabolic processGO:00098931080.029
system processGO:00030081850.028
nucleic acid metabolic processGO:00903042440.028
nucleobase containing compound biosynthetic processGO:00346542050.028
monoamine transportGO:001584410.028
neuron developmentGO:00486662620.028
response to uvGO:000941130.028
negative regulation of signal transductionGO:0009968940.028
positive regulation of apoptotic signaling pathwayGO:200123510.028
regulation of response to nutrient levelsGO:003210710.028
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.028
protein localizationGO:0008104400.027
regulation of establishment of protein localizationGO:007020140.027
regulation of cytoplasmic transportGO:190364940.027
response to metal ionGO:0010038340.027
medulla oblongata developmentGO:002155040.027
regulation of gtpase activityGO:004308720.027
regulation of cellular biosynthetic processGO:00313262450.027
regulation of inflammatory responseGO:005072720.026
regulation of glucose transportGO:001082710.026
regulation of cellular response to oxidative stressGO:190040720.026
cation transportGO:0006812810.026
cellular amino acid metabolic processGO:000652070.026
regulation of blood pressureGO:000821710.026
regulation of epithelial cell proliferationGO:005067830.026
transcription from rna polymerase ii promoterGO:0006366800.026
long chain fatty acid metabolic processGO:000167610.025
regulation of blood vessel sizeGO:005088020.025
neuron differentiationGO:00301823530.025
cellular response to hormone stimulusGO:0032870390.025
reactive oxygen species metabolic processGO:007259360.025
aromatic compound biosynthetic processGO:00194382170.025
brain developmentGO:00074202930.025
transcription dna templatedGO:00063511810.025
cellular response to nutrient levelsGO:003166920.025
regulation of peptidyl tyrosine phosphorylationGO:005073010.025
cellular response to starvationGO:000926710.025
regulation of response to extracellular stimulusGO:003210410.025
organic cyclic compound metabolic processGO:19013603010.025
regulation of rna metabolic processGO:00512522240.025
positive regulation of cytokine productionGO:000181920.025
oxidation reduction processGO:0055114410.024
cellular protein catabolic processGO:004425740.024
regulation of organ growthGO:004662030.024
regulation of wound healingGO:006104120.024
peptide transportGO:001583310.024
cell morphogenesisGO:00009022890.024
guanosine containing compound catabolic processGO:190106920.024
determination of bilateral symmetryGO:00098552040.024
retina development in camera type eyeGO:00600411460.024
response to endogenous stimulusGO:0009719830.024
multicellular organismal metabolic processGO:004423620.023
negative regulation of cellular catabolic processGO:003133030.023
cellular response to unfolded proteinGO:003462020.023
protein complex localizationGO:003150310.023
nitric oxide biosynthetic processGO:000680920.023
gtp metabolic processGO:004603940.023
regulation of nucleoside metabolic processGO:000911820.023
positive regulation of signal transductionGO:0009967560.023
ion transportGO:00068111140.023
small molecule catabolic processGO:004428230.023
macromolecule modificationGO:00434121110.023
adult behaviorGO:003053420.023
heterocycle metabolic processGO:00464832900.023
head developmentGO:00603223030.022
positive regulation of cell cycleGO:004578730.022
guanosine containing compound metabolic processGO:190106840.022
cellular response to endogenous stimulusGO:0071495680.022
locomotionGO:00400113130.022
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.022
regulation of erk1 and erk2 cascadeGO:007037240.022
cellular localizationGO:0051641970.022
sensory organ morphogenesisGO:00905962000.022
regulation of cell activationGO:005086510.022
carboxylic acid metabolic processGO:0019752220.022
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.022
response to hexoseGO:000974630.022
response to decreased oxygen levelsGO:0036293250.022
organophosphate biosynthetic processGO:0090407230.022
regulation of nitrogen compound metabolic processGO:00511712510.022
positive regulation of cellular metabolic processGO:0031325940.021
cellular response to organic substanceGO:00713101050.021
regulation of protein catabolic processGO:004217610.021
response to external stimulusGO:00096052640.021
regulation of oxidative stress induced cell deathGO:190320120.021
positive regulation of cellular processGO:00485222010.021
nitrogen compound metabolic processGO:00068073190.021
positive regulation of map kinase activityGO:004340630.021
cellular component assemblyGO:00226071700.021
positive regulation of macromolecule metabolic processGO:0010604930.021
single organism cellular localizationGO:1902580460.021
stem cell divisionGO:001714510.021
cellular aromatic compound metabolic processGO:00067252950.021
phosphate containing compound metabolic processGO:00067961080.021
regulation of protein ubiquitinationGO:003139630.020
monocarboxylic acid catabolic processGO:007232930.020
negative regulation of autophagyGO:001050710.020
regulation of i kappab kinase nf kappab signalingGO:004312240.020
reactive nitrogen species metabolic processGO:200105700.020
cell motilityGO:00488702440.020
response to monosaccharideGO:003428430.020
negative regulation of mitosisGO:004583930.020
regulation of purine nucleotide catabolic processGO:003312120.020
er nucleus signaling pathwayGO:000698420.020
cellular protein metabolic processGO:00442671290.020
regulation of glucose importGO:004632410.020
regulation of synaptic plasticityGO:004816710.020
response to oxygen levelsGO:0070482250.020
modulation by virus of host morphology or physiologyGO:001904810.020
regulation of carbohydrate metabolic processGO:000610940.020
negative regulation of protein transportGO:005122430.019
centrosome cycleGO:000709810.019
macromolecule localizationGO:0033036540.019
positive regulation of signalingGO:0023056560.019
gtp catabolic processGO:000618420.019
modification dependent protein catabolic processGO:001994130.019
regulation of protein metabolic processGO:0051246560.019
negative regulation of catabolic processGO:000989530.019
cation homeostasisGO:0055080330.019
regulation of bindingGO:005109830.019
response to woundingGO:00096111160.019
response to alkaloidGO:004327920.019
regulation of protein complex assemblyGO:004325430.019
negative regulation of cytoplasmic transportGO:190365020.019
neurological system processGO:0050877620.019
neuroblast proliferationGO:000740520.019
regulation of transporter activityGO:003240920.019
extrinsic apoptotic signaling pathwayGO:009719130.019
enzyme linked receptor protein signaling pathwayGO:00071671060.019
phagocytosisGO:000690930.019
response to carbohydrateGO:000974330.018
chordate embryonic developmentGO:00430092710.018
epithelial tube morphogenesisGO:00605621480.018
response to steroid hormoneGO:0048545350.018
negative regulation of cell communicationGO:0010648960.018
positive regulation of dna metabolic processGO:005105410.018
sensory perception of painGO:001923310.018
deathGO:00162651210.018
inorganic anion transportGO:0015698250.018
cellular transition metal ion homeostasisGO:004691630.018
lipid oxidationGO:003444010.018
negative regulation of response to cytokine stimulusGO:006076120.018
positive regulation of catabolic processGO:000989640.018
morphogenesis of an epitheliumGO:00020093330.018
hormone mediated signaling pathwayGO:000975590.018
cellular protein modification processGO:00064641000.018
regulation of nucleotide catabolic processGO:003081120.018
phosphatidylinositol mediated signalingGO:004801520.018
digestive tract developmentGO:00485652650.018
positive regulation of nucleoside metabolic processGO:004597910.017
response to glucoseGO:000974930.017
regulation of molecular functionGO:0065009700.017
regulation of gtp catabolic processGO:003312420.017
organ regenerationGO:003110010.017
muscle structure developmentGO:00610611960.017
embryonic heart tube developmentGO:00350501330.017
dna templated transcription elongationGO:000635430.017
protein polyubiquitinationGO:000020940.017
positive regulation of neural precursor cell proliferationGO:200017910.017
organic acid catabolic processGO:001605430.017
production of molecular mediator of immune responseGO:000244020.017
cellular response to biotic stimulusGO:007121630.017
nitric oxide metabolic processGO:004620920.017
positive regulation of glucose transportGO:001082810.017
multi organism processGO:00517041340.017
eye morphogenesisGO:00485921440.017
pigmentationGO:0043473850.017
protein modification processGO:00362111000.016
negative regulation of protein phosphorylationGO:000193340.016
positive regulation of wound healingGO:009030310.016
negative regulation of response to stimulusGO:00485851040.016
ameboidal type cell migrationGO:00016671430.016
response to ketoneGO:190165410.016
cell migrationGO:00164772370.016
macroautophagyGO:001623610.016
positive regulation of cell communicationGO:0010647560.016
negative regulation of signal transduction in absence of ligandGO:190109910.016
response to oxygen containing compoundGO:1901700550.016
negative regulation of protein kinase activityGO:000646940.016
odontogenesis of dentin containing toothGO:004247510.016
positive regulation of purine nucleotide catabolic processGO:003312310.016
response to unfolded proteinGO:000698620.016
localization of cellGO:00516742440.015
ion transmembrane transportGO:0034220910.015
regulation of cellular protein metabolic processGO:0032268520.015
proteasomal protein catabolic processGO:001049820.015
positive regulation of response to stimulusGO:0048584800.015
peptide metabolic processGO:000651810.015
muscle cell differentiationGO:00426921390.015
regulation of dendrite developmentGO:005077330.015
nitrogen compound transportGO:0071705230.015
heart developmentGO:00075073130.015
negative regulation of nitrogen compound metabolic processGO:0051172590.015
autophagyGO:000691440.015
ribonucleoside monophosphate catabolic processGO:000915840.015
negative regulation of intracellular protein transportGO:009031730.015
negative regulation of macromolecule metabolic processGO:0010605760.015
regulation of extrinsic apoptotic signaling pathwayGO:200123630.015
carboxylic acid catabolic processGO:004639530.015
negative regulation of signalingGO:0023057960.015
membrane fusionGO:006102520.014
regulation of growth rateGO:004000910.014
golgi vesicle transportGO:004819330.014
cellular component biogenesisGO:00440851780.014
regulation of reproductive processGO:200024140.014
meiotic cell cycle processGO:190304630.014
regulation of lipid transportGO:003236840.014
metal ion homeostasisGO:0055065260.014
dorsal motor nucleus of vagus nerve developmentGO:002174440.014
regulation of nucleic acid templated transcriptionGO:19035062130.014
negative regulation of nuclear divisionGO:005178430.014
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.014
secondary metabolic processGO:001974830.014
multicellular organismal homeostasisGO:0048871290.014
cellular component morphogenesisGO:00329893360.014
negative regulation of kinase activityGO:003367340.014
circulatory system processGO:0003013870.014
response to amino acidGO:004320020.014
cellular response to lipopolysaccharideGO:007122230.014
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.014
single organism membrane fusionGO:004480120.014
centrosome organizationGO:005129710.014
female sex differentiationGO:004666040.014
rna 3 end processingGO:003112320.014
regulation of proteolysisGO:0030162240.014
xenobiotic metabolic processGO:000680540.013
regulation of phosphorus metabolic processGO:0051174430.013
meiotic nuclear divisionGO:000712640.013
kidney developmentGO:0001822920.013
negative regulation of metabolic processGO:0009892860.013
establishment or maintenance of polarity of embryonic epitheliumGO:001633220.013
purine nucleoside monophosphate catabolic processGO:000912840.013
mitotic cell cycle processGO:1903047480.013
cellular component movementGO:00069283350.013
positive regulation of biological processGO:00485182530.013
negative regulation of protein import into nucleusGO:004230820.013
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.013
positive regulation of stem cell proliferationGO:200064810.013
protein modification by small protein removalGO:007064610.013
inositol lipid mediated signalingGO:004801720.013
phosphorus metabolic processGO:00067931090.013
positive regulation of neuron deathGO:190121610.013
fatty acid oxidationGO:001939510.013
neuromast developmentGO:0048884460.013
response to inorganic substanceGO:0010035380.013
b cell activationGO:004211320.013
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.013
regulation of metal ion transportGO:001095940.013
positive regulation of cellular amine metabolic processGO:003324000.013
fatty acid catabolic processGO:000906210.013
transmembrane transportGO:00550851200.013
positive regulation of programmed cell deathGO:0043068290.013
regulation of photoreceptor cell differentiationGO:004653220.012
positive regulation of immune effector processGO:000269930.012
regulation of cellular protein catabolic processGO:190336210.012
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.012
regulation of oocyte developmentGO:006028130.012
cell morphogenesis involved in differentiationGO:00009041950.012
regulation of dna templated transcription in response to stressGO:004362000.012
regulation of heart growthGO:006042020.012
organic substance catabolic processGO:1901575280.012
regulation of synapse organizationGO:005080730.012
triglyceride homeostasisGO:007032820.012
epithelial cell developmentGO:0002064420.012
iron ion homeostasisGO:005507240.012
ion homeostasisGO:0050801410.012
hemopoiesisGO:00300971830.012
regulation of neural precursor cell proliferationGO:200017730.012
embryo development ending in birth or egg hatchingGO:00097922710.012
mononuclear cell proliferationGO:003294310.012
phagocytosis engulfmentGO:000691110.012
cytoskeleton organizationGO:0007010960.012
positive regulation of cellular amino acid metabolic processGO:004576400.012
negative regulation of nucleocytoplasmic transportGO:004682320.012
cellular response to stressGO:0033554620.012
anatomical structure homeostasisGO:0060249360.012
multicellular organismal response to stressGO:003355520.012
anion transportGO:0006820380.012
positive regulation of leukocyte mediated immunityGO:000270510.012
behaviorGO:0007610740.012
compound eye developmentGO:004874920.012
response to topologically incorrect proteinGO:003596620.012
negative regulation of cell deathGO:0060548600.012
cellular response to hypoxiaGO:007145610.012
positive regulation of epithelial cell proliferationGO:005067910.011
negative regulation of mapk cascadeGO:004340940.011
regulation of phosphate metabolic processGO:0019220430.011
cellular monovalent inorganic cation homeostasisGO:003000420.011
axon developmentGO:00615641660.011
negative regulation of protein complex assemblyGO:003133310.011
regulation of response to stressGO:0080134360.011
heart loopingGO:0001947940.011
cell projection morphogenesisGO:00488582440.011
negative regulation of cellular metabolic processGO:0031324770.011
urogenital system developmentGO:0001655970.011
bicarbonate transportGO:001570140.011
response to hydrogen peroxideGO:004254230.011
regulation of dendrite morphogenesisGO:004881430.011
positive regulation of nucleotide catabolic processGO:003081310.011
protein localization to plasma membraneGO:007265910.011
catabolic processGO:0009056320.011
regulation of cell migration involved in sprouting angiogenesisGO:009004930.011
germ line stem cell maintenanceGO:003071820.011
response to light stimulusGO:0009416460.011
specification of symmetryGO:00097992040.011
nuclear exportGO:005116810.011
lymphocyte proliferationGO:004665110.011
divalent inorganic cation homeostasisGO:0072507220.011
regulation of dna replicationGO:000627530.011
glycoprotein biosynthetic processGO:0009101210.011
positive regulation of developmental processGO:0051094500.011
negative regulation of muscle tissue developmentGO:190186220.011
regulation of locomotionGO:0040012550.011
mitochondrion organizationGO:000700540.011
determination of heart left right asymmetryGO:00613711170.011
regulation of response to external stimulusGO:0032101310.011
regulation of multicellular organismal developmentGO:20000262230.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.011
monocarboxylic acid metabolic processGO:0032787170.011
positive regulation of epithelial cell migrationGO:001063420.011
intracellular transportGO:0046907320.011
membrane invaginationGO:001032410.011
regulation of phGO:000688530.011
regulation of response to biotic stimulusGO:000283120.011
cellular component assembly involved in morphogenesisGO:00109271070.011
modification of morphology or physiology of other organismGO:003582140.011
telomere maintenanceGO:000072310.011
signal transduction in absence of ligandGO:003803410.011
response to coldGO:000940940.010
regulation of lipase activityGO:006019120.010
leukocyte proliferationGO:007066110.010
regulation of cellular component movementGO:0051270550.010
positive regulation of neuron apoptotic processGO:004352510.010
organic hydroxy compound transportGO:0015850140.010
interaction with hostGO:005170140.010
regulation of stem cell proliferationGO:007209120.010
regulation of protein localization to plasma membraneGO:190307610.010
positive regulation of gtpase activityGO:004354710.010
cellular response to decreased oxygen levelsGO:003629410.010
positive regulation of multi organism processGO:004390230.010
forebrain cell migrationGO:002188510.010
fatty acid transportGO:001590810.010
membrane lipid biosynthetic processGO:004646720.010
regulation of apoptotic processGO:0042981980.010
mrna 3 end processingGO:003112420.010
camera type eye morphogenesisGO:00485931080.010
atp catabolic processGO:000620040.010
regulation of mitochondrion organizationGO:001082110.010
positive regulation of glucose importGO:004632610.010
regulation of production of molecular mediator of immune responseGO:000270010.010
glycoprotein metabolic processGO:0009100230.010
response to copper ionGO:0046688130.010
chemical homeostasisGO:0048878490.010
phosphatidylinositol 3 kinase signalingGO:001406520.010
positive regulation of lymphocyte mediated immunityGO:000270810.010
carbohydrate derivative biosynthetic processGO:1901137430.010

slc9a8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.091
disease of anatomical entityDOID:700.058
organ system cancerDOID:005068600.053
cancerDOID:16200.053
nervous system diseaseDOID:86300.036
disease of metabolismDOID:001466700.034
endocrine gland cancerDOID:17000.028
inherited metabolic disorderDOID:65500.022
musculoskeletal system diseaseDOID:1700.021
connective tissue diseaseDOID:6500.012
immune system diseaseDOID:291400.011
bone diseaseDOID:008000100.010