Danio rerio

0 known processes

map3k12

mitogen-activated protein kinase kinase kinase 12

(Aliases: MGC77370,zgc:77370)

map3k12 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.074
Worm
cellular component movementGO:00069283350.047
response to chemicalGO:00422213200.045
agingGO:000756820.044
signal transductionGO:00071654550.043
Worm
positive regulation of transportGO:005105020.042
neurotransmitter secretionGO:000726920.041
cell surface receptor signaling pathwayGO:00071663250.041
regulation of signalingGO:00230512350.041
Worm
cell morphogenesisGO:00009022890.040
cell part morphogenesisGO:00329902460.039
cytokinesisGO:000091030.039
embryonic organ developmentGO:00485683810.038
cell projection organizationGO:00300302840.038
maintenance of locationGO:005123540.037
phagocytosisGO:000690930.037
positive regulation of cellular component biogenesisGO:004408930.037
cognitionGO:005089010.036
regulation of synapse organizationGO:005080730.035
Worm
establishment of localizationGO:00512342440.034
digestive system developmentGO:00551232890.034
synaptic vesicle localizationGO:009747910.034
regulation of signal transductionGO:00099662250.034
Worm
regulation of cell communicationGO:00106462320.033
Worm
mitochondrion organizationGO:000700540.033
cell projection morphogenesisGO:00488582440.033
neurotransmitter transportGO:000683620.032
regionalizationGO:00030022740.032
regulation of reproductive processGO:200024140.032
synaptic vesicle transportGO:004848910.032
regulation of multicellular organism growthGO:004001440.032
establishment of synaptic vesicle localizationGO:009748010.030
establishment of protein localization to plasma membraneGO:009000210.030
digestive tract developmentGO:00485652650.030
multicellular organism growthGO:003526440.029
digestive tract morphogenesisGO:00485462310.029
positive regulation of cell cycleGO:004578730.029
tube morphogenesisGO:00352393490.029
regulation of purine nucleotide catabolic processGO:003312120.029
regulation of synapse assemblyGO:005196330.029
meiotic nuclear divisionGO:000712640.028
amine metabolic processGO:000930820.028
regulation of nucleoside metabolic processGO:000911820.028
cell migrationGO:00164772370.028
locomotionGO:00400113130.028
gtp catabolic processGO:000618420.027
gtp metabolic processGO:004603940.027
cellular macromolecule metabolic processGO:00442603910.027
Mouse Worm
chemosensory behaviorGO:000763510.027
system processGO:00030081850.027
cellular amine metabolic processGO:004410620.027
regulation of nucleotide catabolic processGO:003081120.026
lipid storageGO:001991510.026
stem cell proliferationGO:007208940.026
gastrulationGO:00073692080.026
axon developmentGO:00615641660.026
specification of symmetryGO:00097992040.026
microtubule based movementGO:0007018330.025
neuron projection morphogenesisGO:00488121610.025
regulation of biological qualityGO:00650082630.025
Worm
guanosine containing compound metabolic processGO:190106840.025
regulation of gtp catabolic processGO:003312420.025
cellular component morphogenesisGO:00329893360.025
positive regulation of catabolic processGO:000989640.025
embryonic organ morphogenesisGO:00485622740.025
protein localization to plasma membraneGO:007265910.025
regulation of cell shapeGO:000836010.024
neuron differentiationGO:00301823530.024
regulation of synaptic plasticityGO:004816710.024
rna metabolic processGO:00160702190.024
positive regulation of cellular catabolic processGO:003133130.024
guanosine containing compound catabolic processGO:190106920.024
regulation of cellular amine metabolic processGO:003323800.024
response to stressGO:00069502630.023
regulation of metabolic processGO:00192223590.023
Worm
positive regulation of secretion by cellGO:190353210.023
membrane fusionGO:006102520.023
regulation of protein transportGO:005122330.022
regulation of response to stimulusGO:00485832690.022
Worm
regulation of establishment of protein localizationGO:007020140.022
regulation of developmental processGO:00507932470.022
organic cyclic compound metabolic processGO:19013603010.022
transportGO:00068102200.022
stem cell maintenanceGO:001982740.022
exocytosisGO:000688710.022
negative regulation of biological processGO:00485193040.022
neuron neuron synaptic transmissionGO:000727010.022
single organism organelle organizationGO:19025891990.022
Mouse
regulation of multicellular organismal developmentGO:20000262230.022
regulation of primary metabolic processGO:00800903110.021
Worm
single organism transportGO:00447652060.021
single organism localizationGO:19025782250.021
synaptic growth at neuromuscular junctionGO:005112420.021
nucleocytoplasmic transportGO:000691340.021
determination of bilateral symmetryGO:00098552040.021
regulation of protein complex assemblyGO:004325430.021
adult behaviorGO:003053420.021
synaptic transmission cholinergicGO:000727140.020
phagocytosis engulfmentGO:000691110.020
regulation of multicellular organismal processGO:00512392770.020
single organism membrane fusionGO:004480120.020
regulation of nitrogen compound metabolic processGO:00511712510.020
heterocycle metabolic processGO:00464832900.020
regulation of neurotransmitter transportGO:005158810.020
angiogenesisGO:00015251580.020
embryo development ending in birth or egg hatchingGO:00097922710.020
positive regulation of nucleoside metabolic processGO:004597910.020
eye developmentGO:00016542770.020
regulation of synaptic growth at neuromuscular junctionGO:000858210.019
cilium morphogenesisGO:0060271850.019
negative regulation of protein phosphorylationGO:000193340.019
regulation of cytoplasmic transportGO:190364940.019
nuclear importGO:005117030.019
regulation of exocytosisGO:001715710.019
positive regulation of cellular processGO:00485222010.019
Worm
generation of neuronsGO:00486993850.019
organelle organizationGO:00069962270.019
Mouse
nuclear transportGO:005116940.019
localization of cellGO:00516742440.019
aromatic compound biosynthetic processGO:00194382170.019
positive regulation of purine nucleotide catabolic processGO:003312310.019
cellular response to extracellular stimulusGO:003166820.019
cellular nitrogen compound metabolic processGO:00346412900.019
cellular nitrogen compound biosynthetic processGO:00442712180.019
neuron developmentGO:00486662620.019
sensory perception of chemical stimulusGO:000760630.019
rna localizationGO:000640340.019
endosomal transportGO:001619720.019
regulation of muscle contractionGO:000693730.018
organelle fusionGO:004828430.018
regulation of neural precursor cell proliferationGO:200017730.018
negative regulation of cellular processGO:00485232830.018
membrane invaginationGO:001032410.018
macromolecular complex disassemblyGO:003298410.018
regulation of neurotransmitter secretionGO:004692810.018
heart developmentGO:00075073130.018
heart contractionGO:0060047710.018
cilium assemblyGO:0042384580.018
protein polymerizationGO:005125840.018
response to carbohydrateGO:000974330.018
anterior posterior pattern specificationGO:00099521520.018
compound eye developmentGO:004874920.018
regulation of gtpase activityGO:004308720.018
response to external stimulusGO:00096052640.018
morphogenesis of an epitheliumGO:00020093330.017
regulation of nucleobase containing compound metabolic processGO:00192192500.017
carboxylic acid metabolic processGO:0019752220.017
blood vessel developmentGO:00015682460.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
cellular component assembly involved in morphogenesisGO:00109271070.017
positive regulation of biological processGO:00485182530.017
Worm
cellular aromatic compound metabolic processGO:00067252950.017
actin polymerization or depolymerizationGO:000815420.017
vasculature developmentGO:00019442780.017
protein importGO:001703830.017
dorsal ventral pattern formationGO:00099531250.017
regulation of cellular amino acid metabolic processGO:000652100.017
actin filament polymerizationGO:003004120.017
hemopoiesisGO:00300971830.017
protein localization to nucleusGO:003450430.017
organic cyclic compound biosynthetic processGO:19013622230.017
cellular response to nutrient levelsGO:003166920.017
single organism nuclear importGO:190259330.017
synaptic vesicle endocytosisGO:004848810.017
growthGO:00400071740.017
regulation of cellular ketone metabolic processGO:001056570.017
neurological system processGO:0050877620.017
biosynthetic processGO:00090582940.017
regulation of cell activationGO:005086510.017
regulation of mrna processingGO:005068430.016
stem cell divisionGO:001714510.016
positive regulation of gtpase activityGO:004354710.016
organic substance biosynthetic processGO:19015762890.016
gene expressionGO:00104672520.016
heterocycle biosynthetic processGO:00181302150.016
nitrogen compound metabolic processGO:00068073190.016
single organism metabolic processGO:00447102170.016
Mouse Worm
cortical cytoskeleton organizationGO:003086510.016
sensory organ developmentGO:00074233930.016
regulation of embryonic developmentGO:0045995470.016
positive regulation of gtp catabolic processGO:003312610.016
negative regulation of protein kinase activityGO:000646940.016
positive regulation of secretionGO:005104710.016
cytoskeleton dependent cytokinesisGO:006164030.016
positive regulation of nucleotide catabolic processGO:003081310.016
regulation of cell differentiationGO:00455951420.016
regulation of protein polymerizationGO:003227120.016
cellular amino acid metabolic processGO:000652070.016
positive regulation of protein complex assemblyGO:003133420.016
female meiotic divisionGO:000714320.015
alcohol biosynthetic processGO:004616520.015
regulation of transmembrane transporter activityGO:002289820.015
establishment of protein localization to organelleGO:007259440.015
negative regulation of kinase activityGO:003367340.015
negative regulation of signal transductionGO:0009968940.015
enzyme linked receptor protein signaling pathwayGO:00071671060.015
hatchingGO:003518840.015
cellular biosynthetic processGO:00442492860.015
cellular response to external stimulusGO:007149620.015
brain developmentGO:00074202930.015
regulation of circadian rhythmGO:004275240.015
axonogenesisGO:00074091520.015
cellular localizationGO:0051641970.015
multicellular organismal response to stressGO:003355520.015
regulation of bindingGO:005109830.015
regulation of macromolecule metabolic processGO:00602553170.015
Worm
tissue remodelingGO:004877140.015
protein secretionGO:000930610.015
neuromuscular synaptic transmissionGO:000727420.015
lateral inhibitionGO:004633110.015
g protein coupled receptor signaling pathwayGO:0007186740.014
cellular ketone metabolic processGO:0042180110.014
cellular component disassemblyGO:002241110.014
regulation of ion transmembrane transporter activityGO:003241220.014
i kappab kinase nf kappab signalingGO:000724940.014
regulation of meiotic cell cycleGO:005144510.014
regulation of anatomical structure morphogenesisGO:00226031300.014
muscle structure developmentGO:00610611960.014
regulation of intracellular protein transportGO:003315730.014
central nervous system developmentGO:00074173870.014
embryonic heart tube developmentGO:00350501330.014
positive regulation of cytoskeleton organizationGO:005149530.014
neuroblast proliferationGO:000740520.014
actin filament based movementGO:003004810.014
meiotic cell cycle processGO:190304630.014
camera type eye developmentGO:00430102220.014
circulatory system processGO:0003013870.014
atp catabolic processGO:000620040.014
regulation of nucleocytoplasmic transportGO:004682220.014
spermatid developmentGO:000728620.014
cell morphogenesis involved in neuron differentiationGO:00486671630.014
neuron projection developmentGO:00311751800.014
sequestering of metal ionGO:005123830.014
hormone secretionGO:004687920.014
chordate embryonic developmentGO:00430092710.014
synaptic vesicle recyclingGO:003646510.014
proteolysis involved in cellular protein catabolic processGO:005160330.014
cilium organizationGO:0044782710.014
axon ensheathment in central nervous systemGO:003229120.014
regulation of filopodium assemblyGO:005148920.014
cell motilityGO:00488702440.014
response to woundingGO:00096111160.014
intracellular signal transductionGO:0035556850.014
Worm
oxoacid metabolic processGO:0043436310.014
regulation of cytokine productionGO:000181730.014
regulation of peptidyl tyrosine phosphorylationGO:005073010.014
negative regulation of synapse assemblyGO:005196420.013
proteasomal protein catabolic processGO:001049820.013
cell substrate adhesionGO:003158940.013
sequestering of calcium ionGO:005120830.013
regulation of cellular metabolic processGO:00313233200.013
Worm
regulation of neuronal synaptic plasticityGO:004816810.013
b cell activationGO:004211320.013
protein complex disassemblyGO:004324110.013
cellular response to chemical stimulusGO:00708871570.013
modification dependent macromolecule catabolic processGO:004363230.013
response to monosaccharideGO:003428430.013
cell morphogenesis involved in differentiationGO:00009041950.013
developmental growthGO:00485891660.013
organic acid metabolic processGO:0006082310.013
cellular component biogenesisGO:00440851780.013
amino acid transportGO:000686520.013
response to organic substanceGO:00100331530.013
phosphate containing compound metabolic processGO:00067961080.013
Mouse Worm
regulation of mrna splicing via spliceosomeGO:004802430.013
ion transportGO:00068111140.013
regulation of tube sizeGO:003515020.013
regulation of cellular component organizationGO:0051128860.013
Worm
protein targeting to nucleusGO:004474430.013
peptide transportGO:001583310.013
pancreas developmentGO:0031016840.013
calcium mediated signalingGO:001972220.013
hormone transportGO:000991420.013
developmental growth involved in morphogenesisGO:0060560860.013
regulation of cell projection assemblyGO:006049140.013
deathGO:00162651210.013
cell projection assemblyGO:0030031640.013
nuclear migrationGO:000709730.012
ubiquitin dependent protein catabolic processGO:000651130.012
regulation of metal ion transportGO:001095940.012
regulation of sequestering of calcium ionGO:005128240.012
negative regulation of sequestering of calcium ionGO:005128340.012
determination of heart left right asymmetryGO:00613711170.012
positive regulation of reproductive processGO:200024320.012
lateral line system developmentGO:0048925760.012
regulation of gene expressionGO:00104682650.012
immune system processGO:00023762410.012
heart processGO:0003015710.012
nucleic acid templated transcriptionGO:00976591810.012
positive regulation of protein polymerizationGO:003227320.012
symbiosis encompassing mutualism through parasitismGO:004440340.012
negative regulation of signalingGO:0023057960.012
modification dependent protein catabolic processGO:001994130.012
immune system developmentGO:00025201910.012
nucleobase containing compound biosynthetic processGO:00346542050.012
organelle assemblyGO:00709251100.012
nucleic acid metabolic processGO:00903042440.012
cellular protein catabolic processGO:004425740.012
ameboidal type cell migrationGO:00016671430.012
phosphorus metabolic processGO:00067931090.012
Mouse Worm
positive regulation of jnk cascadeGO:004633030.012
autophagyGO:000691440.012
regulation of rna biosynthetic processGO:20011412130.012
vesicle localizationGO:0051648270.012
regulation of alternative mrna splicing via spliceosomeGO:000038110.012
regulation of rna metabolic processGO:00512522240.012
positive regulation of cellular amine metabolic processGO:003324000.012
cellular response to starvationGO:000926710.012
response to hexoseGO:000974630.012
protein homooligomerizationGO:005126030.012
regulation of rho protein signal transductionGO:003502320.012
macromolecule modificationGO:00434121110.012
Mouse Worm
blood vessel morphogenesisGO:00485142160.012
wound healingGO:0042060900.012
cytoplasm organizationGO:000702840.012
purine ribonucleoside monophosphate catabolic processGO:000916940.012
regulation of cell substrate adhesionGO:001081010.012
negative regulation of protein serine threonine kinase activityGO:007190120.012
purine nucleoside monophosphate catabolic processGO:000912840.012
organelle localizationGO:0051640490.012
protein stabilizationGO:005082120.012
mechanosensory behaviorGO:000763820.011
cell matrix adhesionGO:000716040.011
negative regulation of cell communicationGO:0010648960.011
ear developmentGO:00435831270.011
regulation of transporter activityGO:003240920.011
protein dephosphorylationGO:000647030.011
regulation of biosynthetic processGO:00098892500.011
nucleobase containing compound metabolic processGO:00061392740.011
establishment of organelle localizationGO:0051656450.011
muscle cell differentiationGO:00426921390.011
fertilizationGO:000956630.011
protein import into nucleusGO:000660630.011
organonitrogen compound metabolic processGO:1901564740.011
negative regulation of response to stimulusGO:00485851040.011
establishment of vesicle localizationGO:0051650240.011
ventricular cardiac muscle tissue developmentGO:000322930.011
programmed cell deathGO:00125011190.011
developmental programmed cell deathGO:001062340.011
retina development in camera type eyeGO:00600411460.011
cortical actin cytoskeleton organizationGO:003086610.011
regulation of i kappab kinase nf kappab signalingGO:004312240.011
striated muscle cell differentiationGO:00511461290.011
blood circulationGO:0008015870.011
catecholamine metabolic processGO:000658420.011
alternative mrna splicing via spliceosomeGO:000038010.011
tube closureGO:006060610.011
determination of left right symmetryGO:00073681790.011
protein metabolic processGO:00195381830.011
Mouse Worm
cellular response to light stimulusGO:007148240.011
negative regulation of defense responseGO:003134820.011
cell cell signalingGO:0007267520.011
Worm
spermatid differentiationGO:004851520.011
skeletal system developmentGO:00015011810.011
response to uvGO:000941130.011
heart morphogenesisGO:00030071560.011
response to nutrientGO:000758430.011
secondary metabolic processGO:001974830.011
nucleoside monophosphate catabolic processGO:000912540.011
cell deathGO:00082191210.011
neuron projection extensionGO:1990138450.011
ribonucleoside monophosphate catabolic processGO:000915840.011
golgi vesicle transportGO:004819330.011
response to drugGO:004249330.011
regulation of cellular macromolecule biosynthetic processGO:20001122220.011
head developmentGO:00603223030.011
macromolecule biosynthetic processGO:00090592270.011
small molecule metabolic processGO:0044281770.011
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.011
gland developmentGO:00487321430.011
hindbrain developmentGO:0030902910.011
pole plasm assemblyGO:000731540.011
single fertilizationGO:000733830.011
protein acetylationGO:000647320.011
regulation of inflammatory responseGO:005072720.011
leukocyte proliferationGO:007066110.010
transcription dna templatedGO:00063511810.010
heart loopingGO:0001947940.010
embryonic heart tube morphogenesisGO:00031431080.010
carbohydrate homeostasisGO:003350010.010
regulation of protein catabolic processGO:004217610.010
organism emergence from protective structureGO:007168440.010
positive regulation of cell adhesionGO:004578510.010
establishment of localization in cellGO:0051649770.010
catechol containing compound metabolic processGO:000971220.010
developmental cell growthGO:0048588520.010
homeostatic processGO:00425921420.010
cellular component assemblyGO:00226071700.010
muscle cell developmentGO:00550011150.010
hard palate developmentGO:006002240.010
negative regulation of protein complex assemblyGO:003133310.010
axon extensionGO:0048675450.010
cell growthGO:0016049570.010
regulation of dendrite developmentGO:005077330.010
negative regulation of catabolic processGO:000989530.010
glial cell migrationGO:000834730.010
convergent extensionGO:00600261180.010

map3k12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.046
nervous system diseaseDOID:86300.023
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.012
organ system cancerDOID:005068600.012
cardiovascular system diseaseDOID:128700.012
musculoskeletal system diseaseDOID:1700.011
sensory system diseaseDOID:005015500.010
eye and adnexa diseaseDOID:149200.010