Danio rerio

68 known processes

dhfr

dihydrofolate reductase

(Aliases: zgc:86637,cb595)

dhfr biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular aromatic compound metabolic processGO:00067252950.672
biosynthetic processGO:00090582940.499
organic substance biosynthetic processGO:19015762890.494
cellular nitrogen compound metabolic processGO:00346412900.492
sister chromatid cohesionGO:000706220.474
single organism metabolic processGO:00447102170.462
nitrogen compound metabolic processGO:00068073190.444
cellular macromolecule biosynthetic processGO:00346452240.422
mitotic dna integrity checkpointGO:004477440.378
multi organism processGO:00517041340.359
sensory organ developmentGO:00074233930.354
macromolecule biosynthetic processGO:00090592270.353
nucleobase containing compound metabolic processGO:00061392740.349
oocyte maturationGO:000155640.340
pyrimidine containing compound metabolic processGO:007252730.314
signal transductionGO:00071654550.287
positive regulation of biological processGO:00485182530.272
heterocycle metabolic processGO:00464832900.267
cellular biosynthetic processGO:00442492860.264
rna transportGO:005065820.213
dna metabolic processGO:0006259270.213
deoxyribonucleotide biosynthetic processGO:000926310.201
alpha amino acid metabolic processGO:190160530.200
positive regulation of catabolic processGO:000989640.191
regulation of multicellular organismal processGO:00512392770.188
purine ribonucleoside monophosphate catabolic processGO:000916940.175
rna metabolic processGO:00160702190.154
positive regulation of nuclease activityGO:003207510.149
regulation of cellular biosynthetic processGO:00313262450.146
organelle organizationGO:00069962270.140
cellular response to oxygen containing compoundGO:1901701200.137
organic cyclic compound metabolic processGO:19013603010.135
aromatic compound biosynthetic processGO:00194382170.124
cellular nitrogen compound biosynthetic processGO:00442712180.119
positive regulation of cellular processGO:00485222010.104
single organism transportGO:00447652060.103
organic substance catabolic processGO:1901575280.103
regulation of cytokine productionGO:000181730.099
nucleic acid metabolic processGO:00903042440.098
larval developmentGO:000216420.096
regulation of dna metabolic processGO:0051052110.094
regulation of dna replicationGO:000627530.093
response to stressGO:00069502630.090
cellular amino acid biosynthetic processGO:000865220.089
immune system processGO:00023762410.088
response to biotic stimulusGO:0009607970.087
zymogen activationGO:003163830.085
dna catabolic processGO:000630810.084
methylationGO:0032259220.082
chromosome organizationGO:0051276310.082
regulation of response to stimulusGO:00485832690.080
response to external biotic stimulusGO:0043207970.079
cell cycle g1 s phase transitionGO:004484310.077
regulation of cellular macromolecule biosynthetic processGO:20001122220.076
positive regulation of cellular catabolic processGO:003133130.076
organic cyclic compound biosynthetic processGO:19013622230.075
response to organic substanceGO:00100331530.075
response to amineGO:001407510.074
regulation of primary metabolic processGO:00800903110.073
rna biosynthetic processGO:00327741810.071
ribonucleotide metabolic processGO:0009259270.070
double strand break repairGO:000630230.069
regulation of nuclease activityGO:003206910.068
negative regulation of biological processGO:00485193040.067
guanosine containing compound metabolic processGO:190106840.067
regulation of metabolic processGO:00192223590.067
regulation of response to biotic stimulusGO:000283120.065
response to amphetamineGO:000197510.065
catabolic processGO:0009056320.064
purine nucleoside monophosphate catabolic processGO:000912840.064
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.064
single organism biosynthetic processGO:0044711710.062
spindle assembly involved in meiosisGO:009030610.061
muscle structure developmentGO:00610611960.061
positive regulation of cellular metabolic processGO:0031325940.060
regulation of rna biosynthetic processGO:20011412130.059
nucleic acid templated transcriptionGO:00976591810.059
gene expressionGO:00104672520.058
negative regulation of signal transductionGO:0009968940.058
pyrimidine nucleotide metabolic processGO:000622010.058
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.058
deoxyribonucleotide metabolic processGO:000926210.057
immune system developmentGO:00025201910.057
chordate embryonic developmentGO:00430092710.057
negative regulation of cellular processGO:00485232830.056
oxoacid metabolic processGO:0043436310.055
g1 s transition of mitotic cell cycleGO:000008210.055
nucleobase containing compound biosynthetic processGO:00346542050.055
cellular response to superoxideGO:007145120.055
regulation of nucleobase containing compound metabolic processGO:00192192500.054
digestive system developmentGO:00551232890.053
organonitrogen compound biosynthetic processGO:1901566470.052
response to uvGO:000941130.052
regulation of dna recombinationGO:000001820.052
hematopoietic or lymphoid organ developmentGO:00485341910.052
positive regulation of cytokine productionGO:000181920.052
carbohydrate derivative metabolic processGO:1901135610.052
regulation of nucleic acid templated transcriptionGO:19035062130.051
protein metabolic processGO:00195381830.050
guanosine containing compound catabolic processGO:190106920.050
regulation of apoptotic processGO:0042981980.049
small molecule metabolic processGO:0044281770.049
cellular macromolecule metabolic processGO:00442603910.048
negative regulation of cell deathGO:0060548600.048
response to other organismGO:0051707970.048
response to oxygen radicalGO:000030520.048
organic cyclic compound catabolic processGO:1901361150.048
mitochondrion organizationGO:000700540.047
striated muscle tissue developmentGO:00147061100.047
response to vitamin b3GO:003355220.047
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.045
cellular component movementGO:00069283350.045
regulation of nucleotide catabolic processGO:003081120.045
agingGO:000756820.044
ribonucleoside monophosphate catabolic processGO:000915840.044
cytoplasmic pattern recognition receptor signaling pathwayGO:000275310.044
apoptotic processGO:00069151160.044
positive regulation of lipid metabolic processGO:004583410.044
establishment of rna localizationGO:005123630.043
amine metabolic processGO:000930820.043
intra s dna damage checkpointGO:003157310.043
carboxylic acid metabolic processGO:0019752220.043
organonitrogen compound metabolic processGO:1901564740.042
leukocyte proliferationGO:007066110.042
positive regulation of response to stimulusGO:0048584800.042
regulation of dna catabolic processGO:190362410.042
regulation of reproductive processGO:200024140.041
single organism organelle organizationGO:19025891990.040
regulation of macromolecule metabolic processGO:00602553170.039
cellular response to molecule of bacterial originGO:007121930.038
single organism localizationGO:19025782250.037
regulation of macromolecule biosynthetic processGO:00105562250.037
regulation of gene expressionGO:00104682650.036
g2 m transition of mitotic cell cycleGO:000008640.036
cellular response to stressGO:0033554620.036
regulation of purine nucleotide catabolic processGO:003312120.035
nucleoside monophosphate catabolic processGO:000912540.034
growthGO:00400071740.034
regulation of cellular metabolic processGO:00313233200.034
immune effector processGO:0002252230.034
atp catabolic processGO:000620040.034
digestive tract developmentGO:00485652650.034
organic acid metabolic processGO:0006082310.034
muscle organ developmentGO:00075171010.033
regulation of cell communicationGO:00106462320.033
cellular protein catabolic processGO:004425740.032
negative regulation of dna metabolic processGO:005105340.032
nucleic acid transportGO:005065720.031
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.031
response to bacteriumGO:0009617580.031
hemopoiesisGO:00300971830.031
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.030
cellular catabolic processGO:0044248270.030
response to chemicalGO:00422213200.030
mitotic dna damage checkpointGO:004477340.030
long chain fatty acid transportGO:001590910.030
eye developmentGO:00016542770.029
heterocycle biosynthetic processGO:00181302150.029
response to external stimulusGO:00096052640.029
response to drugGO:004249330.029
recombinational repairGO:000072510.029
covalent chromatin modificationGO:0016569200.029
centrosome organizationGO:005129710.029
muscle tissue developmentGO:00605371100.029
macromolecular complex subunit organizationGO:0043933740.028
defense response to virusGO:0051607100.028
regulation of peptidase activityGO:0052547230.028
regulation of catalytic activityGO:0050790550.028
regulation of nitrogen compound metabolic processGO:00511712510.028
regulation of cell deathGO:00109411030.028
reciprocal dna recombinationGO:003582510.028
regulation of histone h3 k9 methylationGO:005157020.028
tube morphogenesisGO:00352393490.028
regulation of establishment of protein localizationGO:007020140.027
negative regulation of programmed cell deathGO:0043069580.027
negative regulation of dna replicationGO:000815620.026
protein complex assemblyGO:0006461300.026
organophosphate metabolic processGO:0019637370.026
nucleoside phosphate metabolic processGO:0006753280.026
cellular response to chemical stimulusGO:00708871570.026
multicellular organism growthGO:003526440.026
double strand break repair via homologous recombinationGO:000072410.026
cellular response to reactive oxygen speciesGO:003461420.026
lymphocyte proliferationGO:004665110.025
histone h3 k4 methylationGO:005156820.025
negative regulation of response to stimulusGO:00485851040.025
maintenance of dna repeat elementsGO:004357020.025
cellular amine metabolic processGO:004410620.025
negative regulation of signalingGO:0023057960.025
regulation of rna metabolic processGO:00512522240.025
blood circulationGO:0008015870.025
cellular modified amino acid metabolic processGO:000657530.025
axis specificationGO:0009798430.025
negative regulation of cell communicationGO:0010648960.024
positive regulation of signal transductionGO:0009967560.024
specification of symmetryGO:00097992040.024
positive regulation of cellular amino acid metabolic processGO:004576400.024
cell agingGO:000756920.024
camera type eye developmentGO:00430102220.024
oocyte developmentGO:0048599140.023
regulation of biological qualityGO:00650082630.023
production of molecular mediator of immune responseGO:000244020.023
negative regulation of metabolic processGO:0009892860.023
type i interferon productionGO:003260620.023
gtp catabolic processGO:000618420.023
positive regulation of nucleobase containing compound metabolic processGO:0045935690.023
proteasomal protein catabolic processGO:001049820.023
exocrine pancreas developmentGO:0031017280.023
establishment of localizationGO:00512342440.023
transcription from rna polymerase ii promoterGO:0006366800.023
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.023
determination of left right symmetryGO:00073681790.022
regulation of gtp catabolic processGO:003312420.022
negative regulation of rna metabolic processGO:0051253480.022
intracellular signal transductionGO:0035556850.022
macromolecular complex assemblyGO:0065003350.022
cell death in response to oxidative stressGO:003647320.022
proteolysis involved in cellular protein catabolic processGO:005160330.022
positive regulation of nitrogen compound metabolic processGO:0051173690.022
regulation of signal transductionGO:00099662250.022
regulation of biosynthetic processGO:00098892500.022
negative regulation of gene expressionGO:0010629650.022
pancreas developmentGO:0031016840.022
regulation of localizationGO:00328791040.021
cell part morphogenesisGO:00329902460.021
epithelial tube morphogenesisGO:00605621480.021
rna localizationGO:000640340.021
cell deathGO:00082191210.021
blood vessel developmentGO:00015682460.021
regulation of protein catabolic processGO:004217610.021
dna biosynthetic processGO:007189730.021
phosphate containing compound metabolic processGO:00067961080.021
response to woundingGO:00096111160.021
regulation of deoxyribonuclease activityGO:003207010.021
regulation of molecular functionGO:0065009700.021
programmed cell deathGO:00125011190.021
regulation of cellular amine metabolic processGO:003323800.021
regulation of bindingGO:005109830.021
maintenance of locationGO:005123540.020
centrosome cycleGO:000709810.020
nucleotide metabolic processGO:0009117280.020
b cell differentiationGO:003018310.020
meiosis iGO:000712710.020
protein homooligomerizationGO:005126030.020
negative regulation of macromolecule metabolic processGO:0010605760.019
cellular macromolecular complex assemblyGO:0034622240.019
positive regulation of metabolic processGO:00098931080.019
estrogen metabolic processGO:000821020.019
nucleobase containing small molecule metabolic processGO:0055086320.019
negative regulation of nucleic acid templated transcriptionGO:1903507450.019
positive regulation of signalingGO:0023056560.019
regulation of programmed cell deathGO:00430671010.019
positive regulation of defense response to virus by hostGO:000223000.019
regulation of cellular response to stressGO:0080135200.019
cell proliferation in forebrainGO:002184630.019
chromosome organization involved in meiosisGO:007019210.019
negative regulation of transcription dna templatedGO:0045892450.018
deathGO:00162651210.018
nucleobase containing compound catabolic processGO:0034655150.018
negative regulation of cellular metabolic processGO:0031324770.018
reciprocal meiotic recombinationGO:000713110.018
positive regulation of multicellular organismal processGO:0051240520.018
regulation of proteolysisGO:0030162240.018
regulation of intracellular signal transductionGO:1902531570.017
deoxyribose phosphate metabolic processGO:001969210.017
response to lipidGO:0033993600.017
positive regulation of erk1 and erk2 cascadeGO:007037420.017
monovalent inorganic cation transportGO:0015672420.017
skeletal system developmentGO:00015011810.017
response to oxygen containing compoundGO:1901700550.017
positive regulation of chromosome segregationGO:005198410.017
cellular response to extracellular stimulusGO:003166820.017
homeostasis of number of cellsGO:0048872620.017
cellular localizationGO:0051641970.017
apoptotic signaling pathwayGO:0097190230.016
telomere organizationGO:003220010.016
nucleobase containing compound transportGO:001593120.016
response to metal ionGO:0010038340.016
negative regulation of apoptotic processGO:0043066550.016
neuroblast fate commitmentGO:001401710.016
mitotic metaphase plate congressionGO:000708010.016
regulation of transcription dna templatedGO:00063552130.016
dicarboxylic acid metabolic processGO:004364810.016
cellular response to external stimulusGO:007149620.016
positive regulation of nucleoside metabolic processGO:004597910.015
modification dependent protein catabolic processGO:001994130.015
adult behaviorGO:003053420.015
modification dependent macromolecule catabolic processGO:004363230.015
regulation of response to stressGO:0080134360.015
germ line stem cell divisionGO:004207810.015
myeloid cell differentiationGO:0030099860.015
lipid storageGO:001991510.015
transcription dna templatedGO:00063511810.014
positive regulation of cellular amine metabolic processGO:003324000.014
cellular response to organic substanceGO:00713101050.014
erythrocyte differentiationGO:0030218540.014
phosphorus metabolic processGO:00067931090.014
striated muscle cell developmentGO:00550021080.014
negative regulation of biosynthetic processGO:0009890550.014
regulation of protein metabolic processGO:0051246560.014
cellular response to dna damage stimulusGO:0006974240.014
muscle cell cellular homeostasisGO:004671650.014
negative regulation of chromosome organizationGO:200125110.014
muscle cell differentiationGO:00426921390.014
protein acylationGO:004354330.014
digestive tract morphogenesisGO:00485462310.013
regulation of immune responseGO:0050776140.013
cell morphogenesisGO:00009022890.013
neuroblast differentiationGO:001401610.013
spindle assembly involved in female meiosisGO:000705610.013
striated muscle cell differentiationGO:00511461290.013
regulation of multicellular organism growthGO:004001440.013
transportGO:00068102200.013
regulation of cell activationGO:005086510.013
protein complex biogenesisGO:0070271300.013
positive regulation of map kinase activityGO:004340630.013
response to amino acidGO:004320020.013
brain developmentGO:00074202930.013
cellular amino acid metabolic processGO:000652070.013
chromatin organizationGO:0006325220.013
protein polymerizationGO:005125840.013
purine containing compound metabolic processGO:0072521290.013
immunoglobulin productionGO:000237710.013
dna replicationGO:000626060.013
positive regulation of immune effector processGO:000269930.012
erythrocyte homeostasisGO:0034101550.012
signal transduction by p53 class mediatorGO:0072331130.012
regulation of cellular amino acid metabolic processGO:000652100.012
immune responseGO:0006955280.012
regulation of nucleoside metabolic processGO:000911820.012
cell growthGO:0016049570.012
immunoglobulin mediated immune responseGO:001606430.012
liver developmentGO:0001889960.012
mrna transportGO:005102820.012
regulation of endopeptidase activityGO:0052548230.012
positive regulation of lymphocyte mediated immunityGO:000270810.012
positive regulation of gliogenesisGO:001401520.012
centrosome duplicationGO:005129810.012
positive regulation of cell activationGO:005086710.012
retina development in camera type eyeGO:00600411460.012
muscle cell developmentGO:00550011150.012
sensory organ morphogenesisGO:00905962000.012
positive regulation of muscle tissue developmentGO:190186310.012
response to nitrogen compoundGO:1901698190.012
extrinsic apoptotic signaling pathwayGO:009719130.012
cellular response to oxygen levelsGO:007145310.012
regulation of protein ubiquitinationGO:003139630.012
regulation of production of molecular mediator of immune responseGO:000270010.011
negative regulation of meiotic cell cycleGO:005144710.011
protein complex subunit organizationGO:0071822460.011
nuclear divisionGO:0000280230.011
locomotionGO:00400113130.011
histone lysine methylationGO:0034968120.011
cellular protein modification processGO:00064641000.011
ear developmentGO:00435831270.011
negative regulation of reproductive processGO:200024230.011
protein acetylationGO:000647320.011
antimicrobial humoral responseGO:001973020.011
purine ribonucleoside triphosphate catabolic processGO:000920760.011
regulation of ventricular cardiac muscle cell membrane repolarizationGO:006030710.011
cell migrationGO:00164772370.011
cellular protein metabolic processGO:00442671290.011
regulation of cellular component movementGO:0051270550.011
histone phosphorylationGO:001657220.011
positive regulation of purine nucleotide catabolic processGO:003312310.011
negative regulation of nucleobase containing compound metabolic processGO:0045934590.011
lipid metabolic processGO:0006629520.011
negative regulation of protein phosphorylationGO:000193340.011
regulation of gtpase activityGO:004308720.011
negative regulation of protein kinase activityGO:000646940.011
morphogenesis of an epithelial foldGO:006057110.011
intracellular steroid hormone receptor signaling pathwayGO:003051850.011
signal transduction by phosphorylationGO:0023014180.010
cellular response to hypoxiaGO:007145610.010
positive regulation of nucleotide catabolic processGO:003081310.010
stem cell maintenanceGO:001982740.010
regulation of heart growthGO:006042020.010
regulation of protein modification by small protein conjugation or removalGO:190332030.010
response to vitaminGO:003327330.010
connective tissue developmentGO:0061448990.010
female gamete generationGO:0007292140.010
vasculature developmentGO:00019442780.010
ribose phosphate metabolic processGO:0019693270.010
cellular component assemblyGO:00226071700.010
peptide metabolic processGO:000651810.010
positive regulation of cell cycleGO:004578730.010

dhfr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.085
inherited metabolic disorderDOID:65500.085
organ system cancerDOID:005068600.036
disease of cellular proliferationDOID:1456600.036
cancerDOID:16200.036
thoracic cancerDOID:509300.014
intestinal cancerDOID:1015500.013
large intestine cancerDOID:567200.013
gastrointestinal system cancerDOID:311900.013
colorectal cancerDOID:925600.013
benign neoplasmDOID:006007200.012
colon cancerDOID:21900.012
colon carcinomaDOID:152000.012
disease of anatomical entityDOID:700.010