Danio rerio

33 known processes

spg11

spastic paraplegia 11

spg11 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.260
cytokinesisGO:000091030.171
regulation of blood pressureGO:000821710.117
response to alkaloidGO:004327920.114
phototransduction visible lightGO:000760320.105
membrane lipid biosynthetic processGO:004646720.081
response to stressGO:00069502630.072
somite developmentGO:0061053960.062
actomyosin structure organizationGO:0031032530.060
sensory perception of chemical stimulusGO:000760630.060
protein polymerizationGO:005125840.059
cognitionGO:005089010.057
biosynthetic processGO:00090582940.057
embryonic organ developmentGO:00485683810.056
single organism metabolic processGO:00447102170.056
regulation of multicellular organism growthGO:004001440.055
regulation of tube sizeGO:003515020.054
sequestering of metal ionGO:005123830.053
taxisGO:00423301090.053
organonitrogen compound metabolic processGO:1901564740.053
maintenance of locationGO:005123540.052
regulation of protein polymerizationGO:003227120.052
organic substance biosynthetic processGO:19015762890.051
regulation of protein complex assemblyGO:004325430.050
multicellular organism growthGO:003526440.050
response to external stimulusGO:00096052640.050
cytoskeleton organizationGO:0007010960.050
cytokinetic processGO:003250620.050
organelle organizationGO:00069962270.046
chordate embryonic developmentGO:00430092710.046
estrogen metabolic processGO:000821020.045
cellular response to chemical stimulusGO:00708871570.045
neuron developmentGO:00486662620.045
calcium ion transport into cytosolGO:006040230.044
cellular response to light stimulusGO:007148240.044
regulation of epithelial cell proliferationGO:005067830.043
embryonic organ morphogenesisGO:00485622740.042
response to chemicalGO:00422213200.042
androgen metabolic processGO:000820920.041
organelle assemblyGO:00709251100.041
skeletal system developmentGO:00015011810.041
sphingolipid biosynthetic processGO:003014820.041
neurotransmitter secretionGO:000726920.040
autophagyGO:000691440.040
regulation of dna templated transcription in response to stressGO:004362000.040
phototransductionGO:000760220.039
response to endogenous stimulusGO:0009719830.039
cell part morphogenesisGO:00329902460.038
generation of neuronsGO:00486993850.038
fat soluble vitamin metabolic processGO:000677540.037
response to abiotic stimulusGO:00096281220.037
regulation of biological qualityGO:00650082630.037
embryonic skeletal system developmentGO:0048706970.037
sequestering of calcium ionGO:005120830.036
regulation of multicellular organismal developmentGO:20000262230.036
cellular response to endogenous stimulusGO:0071495680.036
positive regulation of myeloid cell differentiationGO:004563920.036
cellular biosynthetic processGO:00442492860.035
hormone biosynthetic processGO:004244630.035
neuron differentiationGO:00301823530.034
histone phosphorylationGO:001657220.034
negative regulation of sequestering of calcium ionGO:005128340.034
calcium ion importGO:007050940.034
positive regulation of cellular component biogenesisGO:004408930.033
positive regulation of catabolic processGO:000989640.032
positive regulation of cytosolic calcium ion concentrationGO:000720440.032
spermatid developmentGO:000728620.032
glycolipid biosynthetic processGO:000924710.032
mitochondrion organizationGO:000700540.032
single organism organelle organizationGO:19025891990.031
lipid metabolic processGO:0006629520.031
muscle cell differentiationGO:00426921390.031
agingGO:000756820.029
system processGO:00030081850.029
b cell activationGO:004211320.029
cellular component biogenesisGO:00440851780.029
small molecule metabolic processGO:0044281770.029
axon developmentGO:00615641660.028
regulation of mrna processingGO:005068430.027
homeostatic processGO:00425921420.027
cellular component disassemblyGO:002241110.027
cellular response to radiationGO:007147840.027
hormone metabolic processGO:0042445190.027
muscle structure developmentGO:00610611960.027
organelle fusionGO:004828430.026
nitrogen compound metabolic processGO:00068073190.026
cellular response to starvationGO:000926710.026
protein metabolic processGO:00195381830.026
carbohydrate homeostasisGO:003350010.026
regulation of blood vessel sizeGO:005088020.026
carbohydrate derivative biosynthetic processGO:1901137430.026
phagocytosisGO:000690930.026
cellular amide metabolic processGO:004360340.025
female gonad developmentGO:000858540.025
response to organic substanceGO:00100331530.025
regulation of transcription from rna polymerase ii promoter in response to oxidative stressGO:004361900.025
amine metabolic processGO:000930820.025
endocrine processGO:005088620.025
morphogenesis of an epitheliumGO:00020093330.025
cellular response to extracellular stimulusGO:003166820.025
regulation of cell activationGO:005086510.025
cytosolic calcium ion transportGO:006040130.024
positive regulation of immune effector processGO:000269930.024
regulation of cell differentiationGO:00455951420.024
cell substrate adhesionGO:003158940.024
macromolecule modificationGO:00434121110.024
transportGO:00068102200.024
protein modification processGO:00362111000.024
cellular component morphogenesisGO:00329893360.023
regulation of response to stimulusGO:00485832690.023
regulation of cytokine productionGO:000181730.023
positive regulation of protein complex assemblyGO:003133420.023
cellular response to estrogen stimulusGO:0071391240.023
regulation of response to nutrient levelsGO:003210710.023
response to glucocorticoidGO:005138410.023
development of primary female sexual characteristicsGO:004654540.023
muscle cell developmentGO:00550011150.022
extrinsic apoptotic signaling pathwayGO:009719130.022
actin cytoskeleton organizationGO:0030036630.022
rhodopsin mediated signaling pathwayGO:001605610.022
embryonic cranial skeleton morphogenesisGO:0048701900.022
photoperiodismGO:0009648110.022
cortical cytoskeleton organizationGO:003086510.022
microtubule polymerization or depolymerizationGO:003110930.022
positive regulation of protein polymerizationGO:003227320.022
sodium ion transmembrane transportGO:0035725210.022
cell morphogenesis involved in differentiationGO:00009041950.021
neurotransmitter transportGO:000683620.021
response to oxidative stressGO:0006979110.021
central nervous system developmentGO:00074173870.021
embryo development ending in birth or egg hatchingGO:00097922710.021
exocytosisGO:000688710.021
signal transductionGO:00071654550.021
positive regulation of cellular catabolic processGO:003133130.021
renal system process involved in regulation of systemic arterial blood pressureGO:000307110.021
regulation of synaptic plasticityGO:004816710.021
programmed cell deathGO:00125011190.021
regulation of systemic arterial blood pressureGO:000307310.021
b cell differentiationGO:003018310.021
actin filament based processGO:0030029640.021
cellular nitrogen compound metabolic processGO:00346412900.021
myofibril assemblyGO:0030239480.021
cellular response to nutrient levelsGO:003166920.020
cellular ketone metabolic processGO:0042180110.020
tube morphogenesisGO:00352393490.020
regulation of extrinsic apoptotic signaling pathwayGO:200123630.020
regulation of protein ubiquitinationGO:003139630.020
peptide metabolic processGO:000651810.020
regulation of programmed cell deathGO:00430671010.020
positive regulation of transportGO:005105020.020
locomotionGO:00400113130.020
stem cell maintenanceGO:001982740.019
response to corticosteroidGO:003196010.019
negative regulation of catabolic processGO:000989530.019
regulation of circadian rhythmGO:004275240.019
regulation of cellular amino acid metabolic processGO:000652100.019
single organism membrane fusionGO:004480120.019
embryonic heart tube morphogenesisGO:00031431080.019
cell deathGO:00082191210.019
positive regulation of neuron deathGO:190121610.019
synaptic growth at neuromuscular junctionGO:005112420.019
multi organism processGO:00517041340.019
regulation of metal ion transportGO:001095940.019
actin filament polymerizationGO:003004120.019
mesenchyme developmentGO:00604851270.019
receptor recyclingGO:000188140.019
organonitrogen compound biosynthetic processGO:1901566470.019
production of molecular mediator of immune responseGO:000244020.019
macromolecular complex disassemblyGO:003298410.019
cellular macromolecule metabolic processGO:00442603910.018
negative regulation of kinase activityGO:003367340.018
positive regulation of cytoskeleton organizationGO:005149530.018
positive regulation of epithelial cell proliferationGO:005067910.018
membrane lipid metabolic processGO:0006643100.018
gene expressionGO:00104672520.018
heart developmentGO:00075073130.018
regulation of metabolic processGO:00192223590.018
mechanosensory lateral line system developmentGO:0048881490.018
regulation of multicellular organismal processGO:00512392770.018
cellular component assembly involved in morphogenesisGO:00109271070.018
regulation of cell deathGO:00109411030.018
cellular response to lipopolysaccharideGO:007122230.018
membrane invaginationGO:001032410.018
deathGO:00162651210.018
positive regulation of biological processGO:00485182530.018
negative regulation of cellular processGO:00485232830.017
positive regulation of cell cycleGO:004578730.017
peptidyl serine phosphorylationGO:001810510.017
microtubule cytoskeleton organization involved in mitosisGO:190285010.017
regulation of protein modification by small protein conjugation or removalGO:190332030.017
cell projection morphogenesisGO:00488582440.017
regulation of nucleic acid templated transcriptionGO:19035062130.017
actin polymerization or depolymerizationGO:000815420.017
regulation of sequestering of calcium ionGO:005128240.017
regulation of reproductive processGO:200024140.017
regulation of dna replicationGO:000627530.017
regulation of protein catabolic processGO:004217610.017
regulation of synapse organizationGO:005080730.017
positive regulation of cell divisionGO:005178120.017
cell surface receptor signaling pathwayGO:00071663250.017
cellular protein metabolic processGO:00442671290.017
microtubule polymerizationGO:004678520.017
nucleoside monophosphate catabolic processGO:000912540.017
glucose homeostasisGO:004259310.016
somitogenesisGO:0001756870.016
meiotic nuclear divisionGO:000712640.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016
regulation of signalingGO:00230512350.016
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.016
cellular response to molecule of bacterial originGO:007121930.016
cell migrationGO:00164772370.016
regulation of response to extracellular stimulusGO:003210410.016
somatic muscle developmentGO:000752540.016
regulation of cytoplasmic transportGO:190364940.016
response to uvGO:000941130.016
cellular response to organic substanceGO:00713101050.016
nuclear transportGO:005116940.016
ribonucleoside monophosphate catabolic processGO:000915840.016
regulation of cellular amine metabolic processGO:003323800.016
androgen biosynthetic processGO:000670210.016
single organism biosynthetic processGO:0044711710.016
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.016
smooth muscle contractionGO:000693920.016
atp catabolic processGO:000620040.016
organic cyclic compound biosynthetic processGO:19013622230.016
fluid transportGO:0042044170.016
cellular component assemblyGO:00226071700.015
positive regulation of secretionGO:005104710.015
regulation of neural precursor cell proliferationGO:200017730.015
lipid storageGO:001991510.015
inorganic cation transmembrane transportGO:0098662500.015
heart processGO:0003015710.015
antimicrobial humoral responseGO:001973020.015
regulation of inflammatory responseGO:005072720.015
germ line stem cell maintenanceGO:003071820.015
modification dependent macromolecule catabolic processGO:004363230.015
spermatid differentiationGO:004851520.015
proteasomal protein catabolic processGO:001049820.015
guanosine containing compound metabolic processGO:190106840.015
ion transportGO:00068111140.015
neuron projection developmentGO:00311751800.015
nucleocytoplasmic transportGO:000691340.015
inositol lipid mediated signalingGO:004801720.015
sensory organ developmentGO:00074233930.015
response to steroid hormoneGO:0048545350.015
cellular aromatic compound metabolic processGO:00067252950.015
cytoskeleton dependent cytokinesisGO:006164030.015
negative regulation of apoptotic processGO:0043066550.015
hemopoiesisGO:00300971830.014
response to external biotic stimulusGO:0043207970.014
establishment of protein localization to organelleGO:007259440.014
membrane hyperpolarizationGO:006008110.014
sensory system developmentGO:0048880760.014
regionalizationGO:00030022740.014
negative regulation of protein kinase activityGO:000646940.014
protein secretionGO:000930610.014
cellular amine metabolic processGO:004410620.014
lateral line system developmentGO:0048925760.014
cell divisionGO:0051301200.014
protein complex disassemblyGO:004324110.014
nucleobase containing compound biosynthetic processGO:00346542050.014
regulation of microtubule cytoskeleton organizationGO:007050730.014
regulation of erythrocyte differentiationGO:004564620.014
oxidation reduction processGO:0055114410.014
negative regulation of myeloid cell differentiationGO:004563810.014
cellular protein modification processGO:00064641000.014
neuron projection morphogenesisGO:00488121610.014
regulation of bindingGO:005109830.014
skeletal muscle tissue developmentGO:0007519670.013
cellular response to oxygen levelsGO:007145310.013
negative regulation of protein phosphorylationGO:000193340.013
lateral line developmentGO:0048882660.013
regulation of cellular ketone metabolic processGO:001056570.013
cortical actin cytoskeleton organizationGO:003086610.013
regulation of protein transportGO:005122330.013
microtubule based movementGO:0007018330.013
cellular response to external stimulusGO:007149620.013
single organism transportGO:00447652060.013
mechanosensory behaviorGO:000763820.013
specification of organ identityGO:001009220.013
specification of symmetryGO:00097992040.013
fertilizationGO:000956630.013
positive regulation of dna metabolic processGO:005105410.013
negative regulation of biological processGO:00485193040.013
golgi vesicle transportGO:004819330.013
regulation of system processGO:0044057400.013
heterocycle metabolic processGO:00464832900.013
oxoacid metabolic processGO:0043436310.013
cellular component movementGO:00069283350.013
regulation of apoptotic processGO:0042981980.013
neuron neuron synaptic transmissionGO:000727010.013
regulation of response to biotic stimulusGO:000283120.013
phagocytosis engulfmentGO:000691110.013
positive regulation of epithelial cell differentiationGO:003085820.013
catechol containing compound metabolic processGO:000971220.013
neural crest cell differentiationGO:0014033720.013
regulation of autophagyGO:001050630.013
response to hydrogen peroxideGO:004254230.013
double strand break repairGO:000630230.013
negative regulation of dna replicationGO:000815620.013
regulation of developmental processGO:00507932470.013
regulation of biosynthetic processGO:00098892500.012
peptidyl serine modificationGO:001820920.012
digestive system developmentGO:00551232890.012
immune system processGO:00023762410.012
locomotor rhythmGO:004547530.012
positive regulation of cell activationGO:005086710.012
positive regulation of blood circulationGO:190352420.012
cellular respirationGO:004533330.012
blood circulationGO:0008015870.012
negative regulation of dna metabolic processGO:005105340.012
cellular protein catabolic processGO:004425740.012
purine nucleoside monophosphate catabolic processGO:000912840.012
striated muscle tissue developmentGO:00147061100.012
regulation of cell projection assemblyGO:006049140.012
macroautophagyGO:001623610.012
ubiquitin dependent protein catabolic processGO:000651130.012
phosphate containing compound metabolic processGO:00067961080.012
protein targeting to nucleusGO:004474430.012
liver developmentGO:0001889960.012
gtp catabolic processGO:000618420.012
transcription dna templatedGO:00063511810.012
endocardial cushion formationGO:000327220.012
cellular response to organic cyclic compoundGO:0071407380.012
positive regulation of nucleoside metabolic processGO:004597910.012
oxidative phosphorylationGO:000611910.012
regulation of localizationGO:00328791040.012
regulation of nucleocytoplasmic transportGO:004682220.012
embryonic heart tube developmentGO:00350501330.012
regulation of dendrite morphogenesisGO:004881430.012
gastrulationGO:00073692080.012
stem cell proliferationGO:007208940.012
organic cyclic compound metabolic processGO:19013603010.012
sensory perception of touchGO:005097520.012
immune system developmentGO:00025201910.012
regulation of protein bindingGO:004339330.012
cellular macromolecule biosynthetic processGO:00346452240.012
protein localization to nucleusGO:003450430.012
liposaccharide metabolic processGO:190350980.012
carboxylic acid metabolic processGO:0019752220.012
rna localizationGO:000640340.012
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.012
positive regulation of stress activated mapk cascadeGO:003287430.012
neural crest formationGO:0014029140.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
actin filament based movementGO:003004810.012
carbohydrate derivative metabolic processGO:1901135610.012
cellular response to stressGO:0033554620.012
positive regulation of neutrophil migrationGO:190262400.012
cellular carbohydrate metabolic processGO:004426240.012
striated muscle cell developmentGO:00550021080.012
response to biotic stimulusGO:0009607970.012
purine containing compound metabolic processGO:0072521290.012
eye developmentGO:00016542770.012
apoptotic processGO:00069151160.012
regulation of establishment of protein localizationGO:007020140.011
behaviorGO:0007610740.011
positive regulation of neuron apoptotic processGO:004352510.011
cell cycleGO:0007049930.011
nucleic acid metabolic processGO:00903042440.011
catecholamine metabolic processGO:000658420.011
skeletal muscle organ developmentGO:0060538780.011
cellular response to biotic stimulusGO:007121630.011
cellular amino acid metabolic processGO:000652070.011
cell migration involved in gastrulationGO:0042074790.011
ear developmentGO:00435831270.011
positive regulation of lymphocyte mediated immunityGO:000270810.011
positive regulation of defense response to virus by hostGO:000223000.011
regulation of signal transductionGO:00099662250.011
rna biosynthetic processGO:00327741810.011
protein import into nucleusGO:000660630.011
glutamate receptor signaling pathwayGO:000721510.011
camera type eye developmentGO:00430102220.011
metal ion homeostasisGO:0055065260.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
response to carbohydrateGO:000974330.011
muscle fiber developmentGO:0048747520.011
negative regulation of leukocyte differentiationGO:190210610.011
receptor internalizationGO:003162320.011
protein importGO:001703830.011
er to golgi vesicle mediated transportGO:000688810.011
peptide transportGO:001583310.011
determination of bilateral symmetryGO:00098552040.011
blood vessel morphogenesisGO:00485142160.011
regulation of production of molecular mediator of immune responseGO:000270010.011
establishment of localizationGO:00512342440.011
gtp metabolic processGO:004603940.011
cell projection organizationGO:00300302840.011
positive regulation of secretion by cellGO:190353210.011
detection of external stimulusGO:0009581240.011
heart loopingGO:0001947940.011
regulation of organelle assemblyGO:190211540.011
regulation of erk1 and erk2 cascadeGO:007037240.011
regulation of alternative mrna splicing via spliceosomeGO:000038110.011
embryonic skeletal system morphogenesisGO:0048704930.011
regulation of reactive oxygen species metabolic processGO:200037720.011
intracellular mrna localizationGO:000829810.011
oocyte anterior posterior axis specificationGO:000731440.011
negative regulation of defense responseGO:003134820.011
negative regulation of secretionGO:005104820.011
adult behaviorGO:003053420.011
meiotic cell cycle processGO:190304630.011
regulation of heart contractionGO:0008016320.010
regulation of oocyte developmentGO:006028130.010
somatic cell dna recombinationGO:001644410.010
stem cell divisionGO:001714510.010
negative regulation of cell deathGO:0060548600.010
glycolipid metabolic processGO:000666480.010
regulation of cellular metabolic processGO:00313233200.010
skeletal system morphogenesisGO:00487051020.010
protein modification by small protein removalGO:007064610.010
proteolysis involved in cellular protein catabolic processGO:005160330.010
regulation of wound healingGO:006104120.010
regulation of transcription from rna polymerase ii promoterGO:00063571140.010
neural crest cell developmentGO:0014032620.010
detection of abiotic stimulusGO:0009582240.010
response to xenobiotic stimulusGO:0009410450.010
female sex differentiationGO:004666040.010
regulation of cell substrate adhesionGO:001081010.010
regulation of cellular protein catabolic processGO:190336210.010

spg11 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
sensory system diseaseDOID:005015500.040
eye and adnexa diseaseDOID:149200.040
disease of anatomical entityDOID:700.040
nervous system diseaseDOID:86300.040
eye diseaseDOID:561400.040
disease of cellular proliferationDOID:1456600.025
cancerDOID:16200.025
inherited metabolic disorderDOID:65500.023
disease of metabolismDOID:001466700.023
retinal diseaseDOID:567900.017
organ system cancerDOID:005068600.015