Danio rerio

0 known processes

timp2a

tissue inhibitor of metalloproteinase 2a

(Aliases: MGC136726,timp2,etID32613.12,fa96h09,zgc:136726,wu:fa96h09)

timp2a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
multicellular organismal metabolic processGO:004423620.243
cellular amide metabolic processGO:004360340.181
cellular protein catabolic processGO:004425740.177
plasma membrane repairGO:000177820.154
protein localization to nucleusGO:003450430.133
cognitionGO:005089010.130
nucleoside phosphate metabolic processGO:0006753280.125
Mouse
positive regulation of cytokine productionGO:000181920.120
response to hexoseGO:000974630.116
response to glucoseGO:000974930.108
immune system processGO:00023762410.101
regulation of skeletal muscle tissue developmentGO:004864140.101
response to abiotic stimulusGO:00096281220.100
small molecule metabolic processGO:0044281770.096
Mouse
response to other organismGO:0051707970.091
collagen metabolic processGO:003296320.081
regulation of cellular metabolic processGO:00313233200.081
Mouse
response to chemicalGO:00422213200.079
Mouse
defense response to other organismGO:0098542330.079
response to external biotic stimulusGO:0043207970.078
response to alkaloidGO:004327920.071
regulation of chronic inflammatory responseGO:000267610.070
regulation of cellular amine metabolic processGO:003323800.068
macrophage chemotaxisGO:004824630.067
regulation of biological qualityGO:00650082630.063
larval developmentGO:000216420.063
embryonic organ developmentGO:00485683810.063
convergent extensionGO:00600261180.060
multicellular organismal macromolecule metabolic processGO:004425920.060
response to stressGO:00069502630.059
system processGO:00030081850.058
intestinal absorptionGO:005089220.058
single organism localizationGO:19025782250.056
response to monosaccharideGO:003428430.056
regulation of multicellular organism growthGO:004001440.056
cytoskeleton dependent cytokinesisGO:006164030.054
cellular macromolecule biosynthetic processGO:00346452240.054
response to biotic stimulusGO:0009607970.053
response to external stimulusGO:00096052640.053
response to carbohydrateGO:000974330.052
response to bacteriumGO:0009617580.051
defense responseGO:0006952470.050
taurine metabolic processGO:001953010.049
positive regulation of biological processGO:00485182530.049
Mouse
regulation of cellular carbohydrate metabolic processGO:001067540.048
negative regulation of cell communicationGO:0010648960.048
response to corticosteroidGO:003196010.048
positive regulation of immune effector processGO:000269930.046
zymogen activationGO:003163830.045
positive regulation of cellular component biogenesisGO:004408930.045
regulation of cell activationGO:005086510.045
amine metabolic processGO:000930820.045
organonitrogen compound metabolic processGO:1901564740.044
Mouse
biosynthetic processGO:00090582940.042
gastrulationGO:00073692080.042
growthGO:00400071740.041
regulation of epithelial cell proliferationGO:005067830.040
head developmentGO:00603223030.040
regulation of cytoplasmic transportGO:190364940.040
regulation of multicellular organismal developmentGO:20000262230.039
Mouse
multicellular organism growthGO:003526440.039
negative regulation of blood circulationGO:190352320.038
sequestering of metal ionGO:005123830.037
cellular component morphogenesisGO:00329893360.037
positive regulation of cellular amino acid metabolic processGO:004576400.037
carboxylic acid metabolic processGO:0019752220.037
locomotionGO:00400113130.036
cell cycle processGO:0022402530.036
purine containing compound metabolic processGO:0072521290.036
Mouse
apoptotic signaling pathwayGO:0097190230.036
regulation of response to stimulusGO:00485832690.036
Mouse
mitotic cell cycle processGO:1903047480.036
cell motilityGO:00488702440.036
regulation of blood pressureGO:000821710.035
morphogenesis of an epitheliumGO:00020093330.035
aromatic compound biosynthetic processGO:00194382170.035
carbohydrate derivative metabolic processGO:1901135610.035
Mouse
positive regulation of lymphocyte mediated immunityGO:000270810.035
protein dephosphorylationGO:000647030.034
central nervous system developmentGO:00074173870.034
regulation of extrinsic apoptotic signaling pathwayGO:200123630.034
organic cyclic compound metabolic processGO:19013603010.033
Mouse
reactive oxygen species metabolic processGO:007259360.033
cell proliferationGO:0008283800.033
Mouse
determination of heart left right asymmetryGO:00613711170.032
negative regulation of chemotaxisGO:005092240.032
cellular amine metabolic processGO:004410620.032
positive regulation of cellular processGO:00485222010.032
cytokinesisGO:000091030.032
regulation of nervous system developmentGO:0051960900.031
Mouse
regulation of tube sizeGO:003515020.031
regulation of rna biosynthetic processGO:20011412130.030
negative chemotaxisGO:005091910.030
cell cycle g2 m phase transitionGO:004483940.030
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.029
generation of neuronsGO:00486993850.029
Mouse
muscle structure developmentGO:00610611960.029
golgi vesicle transportGO:004819330.029
nitrogen compound metabolic processGO:00068073190.028
Mouse
branched chain amino acid metabolic processGO:000908110.028
neuronal action potentialGO:0019228180.028
reactive oxygen species biosynthetic processGO:190340910.028
vasculature developmentGO:00019442780.028
cellular carbohydrate metabolic processGO:004426240.028
cell migrationGO:00164772370.028
regulation of carbohydrate metabolic processGO:000610940.028
cellular nitrogen compound metabolic processGO:00346412900.027
Mouse
regulation of chondrocyte differentiationGO:003233010.027
chronic inflammatory responseGO:000254410.027
meiotic nuclear divisionGO:000712640.027
phagocytosisGO:000690930.027
proteolysis involved in cellular protein catabolic processGO:005160330.027
positive regulation of canonical wnt signaling pathwayGO:009026340.027
regulation of cellular amino acid metabolic processGO:000652100.027
phosphorus metabolic processGO:00067931090.026
Mouse
positive regulation of cellular amine metabolic processGO:003324000.026
mononuclear cell proliferationGO:003294310.026
macromolecule biosynthetic processGO:00090592270.026
neurological system processGO:0050877620.026
transcription dna templatedGO:00063511810.026
protein metabolic processGO:00195381830.026
Mouse
leukocyte proliferationGO:007066110.026
positive regulation of catabolic processGO:000989640.026
rna metabolic processGO:00160702190.025
ameboidal type cell migrationGO:00016671430.025
trabecula morphogenesisGO:006138320.025
organic acid metabolic processGO:0006082310.025
hematopoietic or lymphoid organ developmentGO:00485341910.025
regulation of hormone secretionGO:004688320.025
single organism metabolic processGO:00447102170.025
Mouse
cell morphogenesisGO:00009022890.025
synaptic growth at neuromuscular junctionGO:005112420.025
protein importGO:001703830.024
circulatory system processGO:0003013870.024
regulation of bone mineralizationGO:003050020.024
nucleotide metabolic processGO:0009117280.024
Mouse
regulation of developmental processGO:00507932470.024
Mouse
oxoacid metabolic processGO:0043436310.024
regulation of multicellular organismal processGO:00512392770.023
Mouse
response to salt stressGO:0009651100.023
ubiquitin dependent protein catabolic processGO:000651130.023
purine ribonucleotide metabolic processGO:0009150270.023
Mouse
liver developmentGO:0001889960.023
g2 m transition of mitotic cell cycleGO:000008640.023
cellular component movementGO:00069283350.023
cell deathGO:00082191210.023
regulation of ion transmembrane transportGO:0034765180.023
positive regulation of leukocyte mediated immunityGO:000270510.023
peptide transportGO:001583310.022
retina development in camera type eyeGO:00600411460.022
tissue regenerationGO:0042246740.022
cellular aromatic compound metabolic processGO:00067252950.022
Mouse
regulation of skeletal muscle fiber developmentGO:004874220.022
regulation of protein catabolic processGO:004217610.021
positive regulation of protein kinase b signalingGO:005189710.021
neuron deathGO:0070997210.021
negative regulation of heart contractionGO:004582220.021
response to radiationGO:0009314510.021
cellular response to external stimulusGO:007149620.021
autophagyGO:000691440.021
negative regulation of feeding behaviorGO:200025220.021
regulation of protein complex assemblyGO:004325430.020
regulation of canonical wnt signaling pathwayGO:0060828340.020
embryo development ending in birth or egg hatchingGO:00097922710.020
organelle organizationGO:00069962270.020
primitive erythrocyte differentiationGO:006031950.020
septum transversum developmentGO:000334340.020
positive regulation of transportGO:005105020.020
glial cell proliferationGO:001400940.020
peptide metabolic processGO:000651810.020
nucleoside phosphate biosynthetic processGO:1901293210.020
multicellular organismal signalingGO:0035637220.020
blood circulationGO:0008015870.020
positive regulation of cell cycleGO:004578730.019
tube morphogenesisGO:00352393490.019
agingGO:000756820.019
wound healingGO:0042060900.019
cytoskeleton organizationGO:0007010960.019
regulation of cell deathGO:00109411030.019
regulation of biosynthetic processGO:00098892500.019
cell surface receptor signaling pathwayGO:00071663250.019
neuron differentiationGO:00301823530.019
Mouse
b cell activationGO:004211320.019
organic substance biosynthetic processGO:19015762890.018
activation of mapk activityGO:000018730.018
olfactory bulb developmentGO:002177240.018
mucopolysaccharide metabolic processGO:190351020.018
cellular amino acid metabolic processGO:000652070.018
regulation of peptidyl tyrosine phosphorylationGO:005073010.018
nucleic acid templated transcriptionGO:00976591810.018
brain developmentGO:00074202930.018
phosphorylationGO:0016310690.018
Mouse
positive regulation of nitrogen compound metabolic processGO:0051173690.018
regulation of rna metabolic processGO:00512522240.018
bleb assemblyGO:003206010.018
b cell differentiationGO:003018310.018
positive regulation of protein complex assemblyGO:003133420.018
regulation of autophagyGO:001050630.018
lymphocyte proliferationGO:004665110.018
regulation of nucleic acid templated transcriptionGO:19035062130.018
mitotic cell cycleGO:0000278640.018
extrinsic apoptotic signaling pathwayGO:009719130.018
cellular ketone metabolic processGO:0042180110.018
positive regulation of map kinase activityGO:004340630.018
gland developmentGO:00487321430.017
regulation of nitrogen compound metabolic processGO:00511712510.017
Mouse
inositol lipid mediated signalingGO:004801720.017
nucleic acid metabolic processGO:00903042440.017
cell cycle arrestGO:000705010.017
regulation of response to biotic stimulusGO:000283120.017
cytosolic calcium ion transportGO:006040130.017
regulation of endothelial cell proliferationGO:000193610.017
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.017
rrna catabolic processGO:001607510.017
signal transductionGO:00071654550.017
Mouse
cellular response to chemical stimulusGO:00708871570.017
Mouse
positive regulation of cell activationGO:005086710.017
positive regulation of oocyte developmentGO:006028210.017
response to amino acidGO:004320020.017
regulation of transporter activityGO:003240920.017
regulation of cellular ketone metabolic processGO:001056570.017
positive regulation of muscle cell differentiationGO:005114910.017
specification of symmetryGO:00097992040.017
organophosphate metabolic processGO:0019637370.017
Mouse
extracellular matrix assemblyGO:008502910.017
oocyte maturationGO:000155640.017
sequestering of calcium ionGO:005120830.017
insulin like growth factor receptor signaling pathwayGO:004800940.016
regulation of primary metabolic processGO:00800903110.016
Mouse
intramembranous ossificationGO:000195730.016
skeletal muscle organ developmentGO:0060538780.016
production of molecular mediator of immune responseGO:000244020.016
connective tissue developmentGO:0061448990.016
astrocyte differentiationGO:004870810.016
chordate embryonic developmentGO:00430092710.016
establishment of protein localization to organelleGO:007259440.016
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.016
defense response to fungusGO:005083220.016
regulation of cell communicationGO:00106462320.016
Mouse
endosomal transportGO:001619720.016
heterocycle metabolic processGO:00464832900.016
Mouse
regulation of cell motilityGO:2000145460.016
regulation of organelle assemblyGO:190211540.015
mrna polyadenylationGO:000637820.015
membrane invaginationGO:001032410.015
outflow tract morphogenesisGO:000315110.015
cell cycle g1 s phase transitionGO:004484310.015
regulation of synapse organizationGO:005080730.015
cellular response to oxygen containing compoundGO:1901701200.015
ncrna catabolic processGO:003466110.015
cell morphogenesis involved in differentiationGO:00009041950.015
positive regulation of chronic inflammatory responseGO:000267810.015
positive regulation of multicellular organismal processGO:0051240520.015
cellular response to oxygen levelsGO:007145310.015
positive regulation of neuron deathGO:190121610.015
notochord developmentGO:0030903540.015
skeletal system morphogenesisGO:00487051020.015
myeloid leukocyte migrationGO:0097529120.015
muscle organ developmentGO:00075171010.015
response to organic substanceGO:00100331530.015
Mouse
positive regulation of cellular carbohydrate metabolic processGO:001067610.015
negative regulation of sequestering of calcium ionGO:005128340.015
protein polymerizationGO:005125840.014
meiotic cell cycle processGO:190304630.014
embryonic organ morphogenesisGO:00485622740.014
positive regulation of developmental processGO:0051094500.014
heart loopingGO:0001947940.014
cellular response to growth factor stimulusGO:0071363390.014
negative regulation of cellular processGO:00485232830.014
Mouse
cellular biosynthetic processGO:00442492860.014
sprouting angiogenesisGO:0002040530.014
regulation of defense response to virusGO:005068820.014
nucleobase containing small molecule metabolic processGO:0055086320.014
Mouse
immunoglobulin productionGO:000237710.014
response to woundingGO:00096111160.014
gene expressionGO:00104672520.014
Mouse
regenerationGO:0031099910.014
cell part morphogenesisGO:00329902460.014
determination of left right symmetryGO:00073681790.014
positive regulation of lipid metabolic processGO:004583410.014
homeostasis of number of cellsGO:0048872620.014
positive regulation of cell divisionGO:005178120.013
cellular response to decreased oxygen levelsGO:003629410.013
glial cell developmentGO:0021782200.013
cellular macromolecule metabolic processGO:00442603910.013
Mouse
regulation of signalingGO:00230512350.013
Mouse
cellular protein metabolic processGO:00442671290.013
Mouse
regulation of systemic arterial blood pressureGO:000307310.013
negative regulation of defense responseGO:003134820.013
direct ossificationGO:003607230.013
protein modification processGO:00362111000.013
phosphatidylinositol mediated signalingGO:004801520.013
carbohydrate biosynthetic processGO:001605110.013
regulation of synapse assemblyGO:005196330.013
skeletal system developmentGO:00015011810.013
extracellular matrix constituent secretionGO:007027830.013
response to light stimulusGO:0009416460.013
single organism cellular localizationGO:1902580460.013
regulation of signal transductionGO:00099662250.012
Mouse
developmental growthGO:00485891660.012
nucleotide biosynthetic processGO:0009165210.012
nucleobase containing compound biosynthetic processGO:00346542050.012
muscle fiber developmentGO:0048747520.012
response to glucocorticoidGO:005138410.012
regulation of carbohydrate biosynthetic processGO:004325510.012
localization of cellGO:00516742440.012
regulation of blood vessel sizeGO:005088020.012
single organism membrane organizationGO:0044802200.012
cellular response to organic substanceGO:00713101050.012
Mouse
eye developmentGO:00016542770.012
response to hypoxiaGO:0001666250.012
positive regulation of biosynthetic processGO:0009891680.012
regulation of cellular component movementGO:0051270550.012
positive regulation of response to stimulusGO:0048584800.012
regulation of ion transmembrane transporter activityGO:003241220.012
sensory organ developmentGO:00074233930.012
positive regulation of protein deacetylationGO:009031210.012
hepaticobiliary system developmentGO:0061008980.011
negative regulation of protein phosphorylationGO:000193340.011
positive regulation of secretion by cellGO:190353210.011
glycoprotein metabolic processGO:0009100230.011
negative regulation of innate immune responseGO:004582420.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
regulation of molecular functionGO:0065009700.011
Mouse
negative regulation of epithelial cell proliferationGO:005068010.011
positive regulation of leukocyte chemotaxisGO:000269010.011
olfactory lobe developmentGO:002198840.011
regulation of dendrite developmentGO:005077330.011
glutamate receptor signaling pathwayGO:000721510.011
collagen biosynthetic processGO:003296420.011
cellular response to biotic stimulusGO:007121630.011
positive regulation of molecular functionGO:0044093330.011
Mouse
epithelial tube morphogenesisGO:00605621480.011
atp catabolic processGO:000620040.011
erythrocyte differentiationGO:0030218540.011
cellular component assemblyGO:00226071700.011
fin morphogenesisGO:0033334530.011
positive regulation of signal transductionGO:0009967560.011
purine nucleotide metabolic processGO:0006163270.011
Mouse
regulation of system processGO:0044057400.011
primitive hemopoiesisGO:0060215270.011
regulation of cell differentiationGO:00455951420.011
Mouse
phosphate containing compound metabolic processGO:00067961080.011
Mouse
protein import into nucleusGO:000660630.011
negative regulation of dna metabolic processGO:005105340.011
positive regulation of nucleobase containing compound metabolic processGO:0045935690.011
lipid digestionGO:004424130.011
positive regulation of carbohydrate metabolic processGO:004591310.011
digestive tract morphogenesisGO:00485462310.011
lipid metabolic processGO:0006629520.011
intracellular signal transductionGO:0035556850.011
Mouse
regulation of cellular component organizationGO:0051128860.011
cell growthGO:0016049570.010
adipose tissue developmentGO:006061210.010
modification dependent protein catabolic processGO:001994130.010
cellular response to molecule of bacterial originGO:007121930.010
positive regulation of cytosolic calcium ion concentrationGO:000720440.010
positive regulation of epithelial cell differentiationGO:003085820.010
positive regulation of nervous system developmentGO:0051962250.010
ribose phosphate metabolic processGO:0019693270.010
Mouse
regulation of immunoglobulin productionGO:000263710.010
carbohydrate homeostasisGO:003350010.010
regulation of peptidase activityGO:0052547230.010
Mouse
negative regulation of immune responseGO:005077720.010
cellular response to nutrient levelsGO:003166920.010
cellular response to hypoxiaGO:007145610.010
cellular response to vascular endothelial growth factor stimulusGO:003592430.010
regulation of locomotionGO:0040012550.010
nuclear transportGO:005116940.010
lipid storageGO:001991510.010
ribonucleoside monophosphate catabolic processGO:000915840.010
maintenance of locationGO:005123540.010
regulation of cytokine productionGO:000181730.010
cell substrate adhesionGO:003158940.010
regulation of phosphate metabolic processGO:0019220430.010
Mouse
response to drugGO:004249330.010
single organism organelle organizationGO:19025891990.010
negative regulation of response to stimulusGO:00485851040.010
taxisGO:00423301090.010

timp2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.025
neuromuscular diseaseDOID:44000.025
charcot marie tooth disease type 4DOID:005054100.025
disease of anatomical entityDOID:700.025
neuropathyDOID:87000.025
charcot marie tooth diseaseDOID:1059500.025
immune system diseaseDOID:291400.022
disease of metabolismDOID:001466700.020
inherited metabolic disorderDOID:65500.018
lipid metabolism disorderDOID:314600.018
bone marrow diseaseDOID:496100.014
hematopoietic system diseaseDOID:7400.014
amyloidosisDOID:912000.011
acquired metabolic diseaseDOID:006015800.011