Danio rerio

26 known processes

psenen

presenilin enhancer 2 homolog

(Aliases: zgc:109727,pen-2,pen2)

psenen biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell projection organizationGO:00300302840.193
cell projection morphogenesisGO:00488582440.148
cellular component morphogenesisGO:00329893360.095
cell morphogenesisGO:00009022890.091
cell part morphogenesisGO:00329902460.090
modification dependent protein catabolic processGO:001994130.088
agingGO:000756820.081
neuron developmentGO:00486662620.079
cell morphogenesis involved in differentiationGO:00009041950.079
neuron projection developmentGO:00311751800.075
ubiquitin dependent protein catabolic processGO:000651130.069
larval developmentGO:000216420.062
positive regulation of protein complex assemblyGO:003133420.062
single organism transportGO:00447652060.061
somitogenesisGO:0001756870.061
cellular protein catabolic processGO:004425740.060
neuron differentiationGO:00301823530.060
regulation of bindingGO:005109830.059
cellular response to external stimulusGO:007149620.059
central nervous system developmentGO:00074173870.059
nucleobase containing compound biosynthetic processGO:00346542050.058
generation of neuronsGO:00486993850.058
localization of cellGO:00516742440.056
meiotic nuclear divisionGO:000712640.055
response to chemicalGO:00422213200.054
response to external stimulusGO:00096052640.053
regulation of cellular metabolic processGO:00313233200.053
cell surface receptor signaling pathwayGO:00071663250.052
Worm
axonogenesisGO:00074091520.051
heterocycle biosynthetic processGO:00181302150.051
modification dependent macromolecule catabolic processGO:004363230.051
macromolecule biosynthetic processGO:00090592270.049
cellular response to nutrient levelsGO:003166920.047
axon developmentGO:00615641660.047
response to stressGO:00069502630.046
transcription dna templatedGO:00063511810.046
extrinsic apoptotic signaling pathwayGO:009719130.045
positive regulation of cellular processGO:00485222010.045
head developmentGO:00603223030.044
meiotic cell cycle processGO:190304630.044
cell morphogenesis involved in neuron differentiationGO:00486671630.044
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.043
regulation of protein complex assemblyGO:004325430.042
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.042
neuron projection morphogenesisGO:00488121610.041
negative regulation of cellular processGO:00485232830.041
organelle organizationGO:00069962270.041
proteasomal protein catabolic processGO:001049820.041
cellular localizationGO:0051641970.040
purine nucleoside monophosphate catabolic processGO:000912840.039
heterocycle metabolic processGO:00464832900.039
regulation of cell shapeGO:000836010.039
regulation of reproductive processGO:200024140.038
cellular macromolecule biosynthetic processGO:00346452240.038
cellular aromatic compound metabolic processGO:00067252950.038
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.037
cellular component assemblyGO:00226071700.037
regulation of signalingGO:00230512350.037
cellular nitrogen compound biosynthetic processGO:00442712180.037
atp catabolic processGO:000620040.036
positive regulation of map kinase activityGO:004340630.035
positive regulation of cellular component biogenesisGO:004408930.035
signal transductionGO:00071654550.035
Worm
establishment of protein localization to organelleGO:007259440.035
vasculature developmentGO:00019442780.034
organic substance biosynthetic processGO:19015762890.034
response to organic substanceGO:00100331530.034
cellular response to extracellular stimulusGO:003166820.034
cellular component biogenesisGO:00440851780.034
proteolysis involved in cellular protein catabolic processGO:005160330.034
positive regulation of biological processGO:00485182530.033
rna biosynthetic processGO:00327741810.033
positive regulation of transportGO:005105020.033
regulation of signal transductionGO:00099662250.033
chordate embryonic developmentGO:00430092710.032
enzyme linked receptor protein signaling pathwayGO:00071671060.032
regulation of metal ion transportGO:001095940.032
locomotionGO:00400113130.032
single organism localizationGO:19025782250.032
organelle fusionGO:004828430.031
nuclear transportGO:005116940.031
amine metabolic processGO:000930820.030
nitrogen compound metabolic processGO:00068073190.030
deathGO:00162651210.030
nucleic acid templated transcriptionGO:00976591810.030
single organism metabolic processGO:00447102170.030
segmentationGO:0035282970.030
regulation of synaptic plasticityGO:004816710.030
positive regulation of cytoskeleton organizationGO:005149530.029
regulation of protein modification by small protein conjugation or removalGO:190332030.029
protein localization to nucleusGO:003450430.029
regulation of metabolic processGO:00192223590.029
negative regulation of protein phosphorylationGO:000193340.029
secondary metabolic processGO:001974830.029
regulation of extrinsic apoptotic signaling pathwayGO:200123630.029
neuroblast proliferationGO:000740520.029
regulation of oocyte developmentGO:006028130.028
regulation of nucleic acid templated transcriptionGO:19035062130.028
lipid storageGO:001991510.028
regulation of cellular amino acid metabolic processGO:000652100.028
aromatic compound biosynthetic processGO:00194382170.028
phosphate containing compound metabolic processGO:00067961080.028
sensory organ developmentGO:00074233930.028
cellular response to chemical stimulusGO:00708871570.028
brain developmentGO:00074202930.028
regulation of cellular biosynthetic processGO:00313262450.028
blood vessel developmentGO:00015682460.028
protein targeting to nucleusGO:004474430.028
stem cell maintenanceGO:001982740.028
stem cell proliferationGO:007208940.027
purine ribonucleoside monophosphate catabolic processGO:000916940.027
morphogenesis of an epitheliumGO:00020093330.027
taxisGO:00423301090.027
cellular nitrogen compound metabolic processGO:00346412900.027
regulation of cell developmentGO:00602841000.027
single organism nuclear importGO:190259330.027
cellular component movementGO:00069283350.026
regulation of cellular amine metabolic processGO:003323800.026
gene expressionGO:00104672520.026
cellular amine metabolic processGO:004410620.026
maintenance of locationGO:005123540.025
cellular biosynthetic processGO:00442492860.025
regulation of macromolecule biosynthetic processGO:00105562250.025
transportGO:00068102200.025
heart developmentGO:00075073130.024
cellular ketone metabolic processGO:0042180110.024
immune system processGO:00023762410.024
regulation of biosynthetic processGO:00098892500.024
regulation of protein ubiquitinationGO:003139630.024
response to other organismGO:0051707970.024
organic cyclic compound metabolic processGO:19013603010.024
cellular response to organic substanceGO:00713101050.024
gastrulationGO:00073692080.023
meiotic chromosome segregationGO:004513230.023
digestive tract morphogenesisGO:00485462310.023
exocytosisGO:000688710.023
organonitrogen compound metabolic processGO:1901564740.023
transcription from rna polymerase ii promoterGO:0006366800.023
cell proliferationGO:0008283800.023
multi organism processGO:00517041340.022
Worm
cell motilityGO:00488702440.022
regulation of cell differentiationGO:00455951420.022
nucleocytoplasmic transportGO:000691340.022
cell migrationGO:00164772370.022
fertilizationGO:000956630.022
regulation of gene expressionGO:00104682650.022
peptidyl serine phosphorylationGO:001810510.022
tube morphogenesisGO:00352393490.022
regulation of cell communicationGO:00106462320.022
positive regulation of cell cycleGO:004578730.022
regulation of cellular ketone metabolic processGO:001056570.022
membrane fusionGO:006102520.021
regulation of anatomical structure morphogenesisGO:00226031300.021
retina development in camera type eyeGO:00600411460.021
response to woundingGO:00096111160.021
positive regulation of cellular catabolic processGO:003133130.021
lateral inhibitionGO:004633110.021
regulation of calcium ion transportGO:005192420.021
regulation of developmental processGO:00507932470.021
rna metabolic processGO:00160702190.021
digestive system developmentGO:00551232890.021
Worm
regulation of peptidyl tyrosine phosphorylationGO:005073010.021
cytoskeleton dependent cytokinesisGO:006164030.020
nucleobase containing compound metabolic processGO:00061392740.020
endocrine processGO:005088620.020
regulation of neuron projection developmentGO:0010975400.020
cellular amino acid metabolic processGO:000652070.020
negative regulation of biological processGO:00485193040.020
nucleoside monophosphate catabolic processGO:000912540.020
single organism membrane fusionGO:004480120.020
regulation of cytoplasmic transportGO:190364940.020
camera type eye developmentGO:00430102220.020
regulation of meiotic cell cycleGO:005144510.020
cellular response to starvationGO:000926710.020
regulation of rna metabolic processGO:00512522240.019
dorsal ventral pattern formationGO:00099531250.019
regulation of cellular protein catabolic processGO:190336210.019
regulation of biological qualityGO:00650082630.019
response to corticosteroidGO:003196010.019
embryo development ending in birth or egg hatchingGO:00097922710.019
Worm
negative regulation of catabolic processGO:000989530.019
glial cell migrationGO:000834730.019
muscle hypertrophyGO:001489620.019
positive regulation of gene expressionGO:0010628710.019
biosynthetic processGO:00090582940.019
response to nutrientGO:000758430.019
regulation of macromolecule metabolic processGO:00602553170.019
organic acid metabolic processGO:0006082310.018
cellular macromolecule metabolic processGO:00442603910.018
Mouse
protein import into nucleusGO:000660630.018
somatic muscle developmentGO:000752540.018
regulation of transporter activityGO:003240920.018
regulation of cytokine productionGO:000181730.018
canonical wnt signaling pathwayGO:0060070480.018
regulation of establishment of protein localizationGO:007020140.018
positive regulation of epithelial cell migrationGO:001063420.018
peptidyl serine modificationGO:001820920.018
negative regulation of cell communicationGO:0010648960.018
hormone transportGO:000991420.018
autophagyGO:000691440.018
synaptic growth at neuromuscular junctionGO:005112420.018
regulation of transcription from rna polymerase ii promoterGO:00063571140.018
regulation of response to stimulusGO:00485832690.018
regulation of synaptic growth at neuromuscular junctionGO:000858210.018
chemotaxisGO:00069351040.018
protein importGO:001703830.018
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.018
regulation of filopodium assemblyGO:005148920.017
golgi vesicle transportGO:004819330.017
establishment of localizationGO:00512342440.017
mitochondrion organizationGO:000700540.017
regulation of epithelial cell proliferationGO:005067830.017
angiogenesisGO:00015251580.017
regulation of synapse assemblyGO:005196330.017
response to glucocorticoidGO:005138410.017
cell death in response to oxidative stressGO:003647320.017
regulation of nitrogen compound metabolic processGO:00511712510.017
behaviorGO:0007610740.017
Worm
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.017
regulation of multicellular organismal developmentGO:20000262230.017
oxoacid metabolic processGO:0043436310.017
regulation of cellular macromolecule biosynthetic processGO:20001122220.017
spindle assembly involved in mitosisGO:009030710.017
synaptic vesicle transportGO:004848910.017
negative regulation of nuclear divisionGO:005178430.017
regulation of axonogenesisGO:0050770320.017
phagocytosisGO:000690930.017
cellular response to stressGO:0033554620.017
neurotransmitter transportGO:000683620.017
negative regulation of kinase activityGO:003367340.017
regulation of embryonic developmentGO:0045995470.017
adult behaviorGO:003053420.016
synaptic vesicle localizationGO:009747910.016
ribonucleoside monophosphate catabolic processGO:000915840.016
negative regulation of protein kinase activityGO:000646940.016
protein metabolic processGO:00195381830.016
Mouse
mononuclear cell proliferationGO:003294310.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
pronuclear migrationGO:003504610.016
somite developmentGO:0061053960.016
cell fate specificationGO:0001708680.016
centrosome organizationGO:005129710.016
positive regulation of epithelial cell differentiationGO:003085820.016
peptide transportGO:001583310.016
apoptotic process involved in developmentGO:190274220.016
striated muscle cell differentiationGO:00511461290.016
positive regulation of signalingGO:0023056560.016
regulation of protein transportGO:005122330.016
cellular transition metal ion homeostasisGO:004691630.016
positive regulation of catabolic processGO:000989640.016
regulation of synapse organizationGO:005080730.016
antimicrobial humoral responseGO:001973020.016
intracellular signal transductionGO:0035556850.016
phosphorylationGO:0016310690.015
positive regulation of erk1 and erk2 cascadeGO:007037420.015
response to external biotic stimulusGO:0043207970.015
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.015
mesenchyme developmentGO:00604851270.015
apoptotic processGO:00069151160.015
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.015
anterior posterior pattern specificationGO:00099521520.015
cell fate commitmentGO:0045165990.015
Worm
eye morphogenesisGO:00485921440.015
nucleic acid metabolic processGO:00903042440.015
pigmentationGO:0043473850.015
retina morphogenesis in camera type eyeGO:0060042790.015
erk1 and erk2 cascadeGO:007037140.015
regulation of multicellular organismal processGO:00512392770.015
phosphorus metabolic processGO:00067931090.015
signal transduction in absence of ligandGO:003803410.015
protein complex localizationGO:003150310.015
wnt signaling pathwayGO:0016055800.014
embryonic limb morphogenesisGO:003032620.014
muscle structure developmentGO:00610611960.014
pole plasm assemblyGO:000731540.014
stem cell divisionGO:001714510.014
regulation of carbohydrate metabolic processGO:000610940.014
negative regulation of mitosisGO:004583930.014
germ line stem cell maintenanceGO:003071820.014
regulation of i kappab kinase nf kappab signalingGO:004312240.014
regulation of receptor activityGO:001046920.014
ion transportGO:00068111140.014
cytokinetic processGO:003250620.014
regulation of oxidative stress induced cell deathGO:190320120.014
positive regulation of apoptotic signaling pathwayGO:200123510.014
eye developmentGO:00016542770.014
cell cell signalingGO:0007267520.014
regulation of wound healingGO:006104120.014
cognitionGO:005089010.014
positive regulation of cellular amine metabolic processGO:003324000.014
blood vessel morphogenesisGO:00485142160.014
regulation of mitochondrion organizationGO:001082110.013
epithelial cell differentiationGO:00308551160.013
regulation of intracellular protein transportGO:003315730.013
ion transmembrane transportGO:0034220910.013
microtubule organizing center organizationGO:003102310.013
cellular carbohydrate metabolic processGO:004426240.013
organelle localizationGO:0051640490.013
cellular protein metabolic processGO:00442671290.013
Mouse
odontogenesis of dentin containing toothGO:004247510.013
organic cyclic compound biosynthetic processGO:19013622230.013
single organism organelle organizationGO:19025891990.013
post embryonic organ developmentGO:004856940.013
regulation of cellular component organizationGO:0051128860.013
muscle cell developmentGO:00550011150.013
regulation of response to cytokine stimulusGO:006075930.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
negative regulation of response to stimulusGO:00485851040.013
vacuolar transportGO:000703420.013
regulation of muscle hypertrophyGO:001474320.013
cell cycle processGO:0022402530.013
compound eye developmentGO:004874920.013
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.013
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.013
b cell differentiationGO:003018310.013
small molecule metabolic processGO:0044281770.013
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
embryonic cranial skeleton morphogenesisGO:0048701900.012
regulation of erk1 and erk2 cascadeGO:007037240.012
guanosine containing compound metabolic processGO:190106840.012
positive regulation of macromolecule metabolic processGO:0010604930.012
regulation of inflammatory responseGO:005072720.012
positive regulation of cell divisionGO:005178120.012
carboxylic acid metabolic processGO:0019752220.012
negative regulation of apoptotic processGO:0043066550.012
regulation of transcription dna templatedGO:00063552130.012
i kappab kinase nf kappab signalingGO:000724940.012
muscle tissue developmentGO:00605371100.012
mesenchymal cell developmentGO:0014031780.012
regulation of primary metabolic processGO:00800903110.012
single fertilizationGO:000733830.012
mesenchymal cell differentiationGO:0048762870.012
positive regulation of cellular metabolic processGO:0031325940.012
adherens junction organizationGO:003433240.012
lymphocyte proliferationGO:004665110.012
regulation of response to oxidative stressGO:190288220.012
negative regulation of cytoplasmic transportGO:190365020.012
positive regulation of transcription dna templatedGO:0045893570.012
hormone secretionGO:004687920.012
negative regulation of programmed cell deathGO:0043069580.012
response to drugGO:004249330.012
developmental growth involved in morphogenesisGO:0060560860.012
positive regulation of stress activated mapk cascadeGO:003287430.012
negative regulation of intracellular transportGO:003238730.012
regulation of rna biosynthetic processGO:20011412130.012
camera type eye morphogenesisGO:00485931080.012
gtp catabolic processGO:000618420.011
negative regulation of macromolecule metabolic processGO:0010605760.011
homeostatic processGO:00425921420.011
neurotransmitter secretionGO:000726920.011
reflexGO:006000420.011
actin cytoskeleton organizationGO:0030036630.011
cytoskeleton organizationGO:0007010960.011
endosomal transportGO:001619720.011
guanosine containing compound catabolic processGO:190106920.011
positive regulation of cell communicationGO:0010647560.011
response to carbohydrateGO:000974330.011
neuron neuron synaptic transmissionGO:000727010.011
response to endogenous stimulusGO:0009719830.011
receptor recyclingGO:000188140.011
beta amyloid metabolic processGO:005043510.011
embryonic skeletal system developmentGO:0048706970.011
glucose homeostasisGO:004259310.011
lipid catabolic processGO:001604240.011
actin filament based movementGO:003004810.011
regulation of protein bindingGO:004339330.011
positive regulation of dna metabolic processGO:005105410.011
negative regulation of signalingGO:0023057960.011
regulation of receptor recyclingGO:000191930.011
dna templated transcription initiationGO:000635210.011
tissue remodelingGO:004877140.011
hematopoietic or lymphoid organ developmentGO:00485341910.011
nuclear importGO:005117030.011
actin mediated cell contractionGO:007025210.011
b cell activationGO:004211320.011
symbiosis encompassing mutualism through parasitismGO:004440340.011
mitochondrial transportGO:000683920.011
negative regulation of synapse assemblyGO:005196420.011
dorsal ventral neural tube patterningGO:002190410.011
cellular component disassemblyGO:002241110.011
development of primary female sexual characteristicsGO:004654540.011
regulation of autophagyGO:001050630.011
lens development in camera type eyeGO:0002088220.011
carbohydrate homeostasisGO:003350010.011
cortical actin cytoskeleton organizationGO:003086610.011
interspecies interaction between organismsGO:004441940.011
response to biotic stimulusGO:0009607970.011
negative regulation of protein transportGO:005122430.011
stem cell differentiationGO:00488631170.011
carbohydrate derivative metabolic processGO:1901135610.011
nuclear transcribed mrna catabolic process nonsense mediated decayGO:000018440.011
response to monosaccharideGO:003428430.011
regulation of wnt signaling pathwayGO:0030111530.011
positive regulation of protein polymerizationGO:003227320.011
cation transportGO:0006812810.010
protein stabilizationGO:005082120.010
regulation of apoptotic processGO:0042981980.010
positive regulation of rna metabolic processGO:0051254590.010
gtp metabolic processGO:004603940.010
negative regulation of reproductive processGO:200024230.010
peptide metabolic processGO:000651810.010
positive regulation of chromosome organizationGO:200125210.010
spindle assemblyGO:005122520.010
forebrain cell migrationGO:002188510.010
mitotic cell cycle embryonicGO:004544820.010
skeletal muscle tissue developmentGO:0007519670.010
muscle organ developmentGO:00075171010.010
digestive tract developmentGO:00485652650.010
Worm
negative regulation of epithelial cell proliferationGO:005068010.010
regulation of transmembrane transporter activityGO:002289820.010
oocyte anterior posterior axis specificationGO:000731440.010
cell deathGO:00082191210.010
protein polyubiquitinationGO:000020940.010
regionalizationGO:00030022740.010
energy reserve metabolic processGO:000611220.010
striated muscle cell developmentGO:00550021080.010
regulation of neurogenesisGO:0050767870.010
pancreas developmentGO:0031016840.010
vacuole organizationGO:000703390.010

psenen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.036
inherited metabolic disorderDOID:65500.027
disease of anatomical entityDOID:700.025
nervous system diseaseDOID:86300.021
cardiovascular system diseaseDOID:128700.020
cancerDOID:16200.017
disease of cellular proliferationDOID:1456600.017
musculoskeletal system diseaseDOID:1700.016
organ system cancerDOID:005068600.011