IMP: Integrative Multi-species Prediction

Danio rerio

125 known processes

prkci

protein kinase C, iota

(Aliases: aPKC[l],has,hal)

Entrez: 117507
ZFIN: ZDB-GENE-011105-1
Ensembl: ENSDARG00000021225
UniProtKB: Q6DI53
UniProtKB: Q90XF2

Process Predictions
Disease Predictions

prkci biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
heart development	GO:0007507	313	0.967
generation of neurons	GO:0048699	385	0.946
regulation of macromolecule metabolic process	GO:0060255	317	0.939	Human Yeast
regionalization	GO:0003002	274	0.889
larval development	GO:0002164	2	0.873	Worm
cell morphogenesis	GO:0000902	289	0.833
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.816	Human Yeast
cell projection morphogenesis	GO:0048858	244	0.785
cellular component morphogenesis	GO:0032989	336	0.766
locomotion	GO:0040011	313	0.752
neuron development	GO:0048666	262	0.747	Human Mouse
rna biosynthetic process	GO:0032774	181	0.719	Human
regulation of developmental process	GO:0050793	247	0.714	Human Zebrafish Worm
cell projection organization	GO:0030030	284	0.678	Human
regulation of nucleic acid templated transcription	GO:1903506	213	0.655	Human
establishment of localization	GO:0051234	244	0.647
regulation of rna metabolic process	GO:0051252	224	0.623	Human Yeast
odontogenesis of dentin containing tooth	GO:0042475	1	0.613
asymmetric protein localization	GO:0008105	6	0.602	Worm
apical protein localization	GO:0045176	6	0.593
cell part morphogenesis	GO:0032990	246	0.587
camera type eye development	GO:0043010	222	0.560
tube morphogenesis	GO:0035239	349	0.559
establishment of epithelial cell polarity	GO:0090162	2	0.544
regulation of biological quality	GO:0065008	263	0.542
somitogenesis	GO:0001756	87	0.538
cellular component movement	GO:0006928	335	0.529
immune system development	GO:0002520	191	0.528	Zebrafish
ameboidal type cell migration	GO:0001667	143	0.520
central nervous system development	GO:0007417	387	0.514
retina development in camera type eye	GO:0060041	146	0.512
localization of cell	GO:0051674	244	0.509
cytoskeleton organization	GO:0007010	96	0.506
neuron differentiation	GO:0030182	353	0.501	Human Mouse
medulla oblongata development	GO:0021550	4	0.494
cell fate commitment	GO:0045165	99	0.483
regulation of cellular biosynthetic process	GO:0031326	245	0.482	Human
establishment of cell polarity	GO:0030010	18	0.477
vasculature development	GO:0001944	278	0.475	Zebrafish
heart looping	GO:0001947	94	0.472
embryonic heart tube development	GO:0035050	133	0.470
establishment or maintenance of bipolar cell polarity	GO:0061245	12	0.461
cell motility	GO:0048870	244	0.439
gene expression	GO:0010467	252	0.429	Human Yeast
chordate embryonic development	GO:0043009	271	0.427
regulation of cell morphogenesis	GO:0022604	42	0.419
heart morphogenesis	GO:0003007	156	0.415
morphogenesis of an epithelium	GO:0002009	333	0.411
neuron projection morphogenesis	GO:0048812	161	0.411
establishment or maintenance of epithelial cell apical basal polarity	GO:0045197	11	0.402
regulation of neuron differentiation	GO:0045664	56	0.401	Human
response to stress	GO:0006950	263	0.394
regulation of cellular metabolic process	GO:0031323	320	0.385	Human Yeast
positive regulation of biological process	GO:0048518	253	0.367	Human Zebrafish Mouse
chemotaxis	GO:0006935	104	0.363
regulation of macromolecule biosynthetic process	GO:0010556	225	0.361	Human
eye development	GO:0001654	277	0.360
phosphorus metabolic process	GO:0006793	109	0.360	Human Yeast Mouse Worm
embryo development ending in birth or egg hatching	GO:0009792	271	0.352
cellular nitrogen compound metabolic process	GO:0034641	290	0.343	Human Yeast
regulation of cell differentiation	GO:0045595	142	0.339	Human
somite development	GO:0061053	96	0.336
regulation of anatomical structure morphogenesis	GO:0022603	130	0.329	Zebrafish
regulation of cellular component organization	GO:0051128	86	0.323	Human Yeast Mouse
epithelial tube formation	GO:0072175	19	0.323
developmental growth involved in morphogenesis	GO:0060560	86	0.315
establishment or maintenance of polarity of embryonic epithelium	GO:0016332	2	0.315
positive regulation of cellular process	GO:0048522	201	0.311	Human
single organism transport	GO:0044765	206	0.307	Zebrafish Mouse
specification of symmetry	GO:0009799	204	0.305
regulation of nitrogen compound metabolic process	GO:0051171	251	0.292	Human Yeast
sensory organ morphogenesis	GO:0090596	200	0.291
heart jogging	GO:0003146	40	0.286
odontogenesis	GO:0042476	9	0.283
nucleobase containing compound metabolic process	GO:0006139	274	0.281	Human Yeast
cell morphogenesis involved in differentiation	GO:0000904	195	0.277
establishment of monopolar cell polarity	GO:0061162	2	0.273	Mouse
embryonic heart tube morphogenesis	GO:0003143	108	0.270
axonogenesis	GO:0007409	152	0.268
epithelial cell differentiation	GO:0030855	116	0.267
stem cell development	GO:0048864	82	0.266
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.264	Human
positive regulation of cell matrix adhesion	GO:0001954	1	0.263
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.257	Human
biosynthetic process	GO:0009058	294	0.256	Human
response to abiotic stimulus	GO:0009628	122	0.255
regulation of cell development	GO:0060284	100	0.255	Human
single organism organelle organization	GO:1902589	199	0.254
wnt signaling pathway	GO:0016055	80	0.246
nitrogen compound metabolic process	GO:0006807	319	0.245	Human Yeast
positive regulation of cellular metabolic process	GO:0031325	94	0.245
meiotic nuclear division	GO:0007126	4	0.244
embryonic organ development	GO:0048568	381	0.243
hepaticobiliary system development	GO:0061008	98	0.240
neuron projection development	GO:0031175	180	0.240	Human
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.235
cellular biosynthetic process	GO:0044249	286	0.234	Human
regulation of gene expression	GO:0010468	265	0.228	Human Yeast
regulation of molecular function	GO:0065009	70	0.226	Human
digestive tract morphogenesis	GO:0048546	231	0.223
taxis	GO:0042330	109	0.222
mitotic cell cycle process	GO:1903047	48	0.221
cell migration	GO:0016477	237	0.221
regulation of signal transduction	GO:0009966	225	0.210
digestive tract development	GO:0048565	265	0.209
blood vessel morphogenesis	GO:0048514	216	0.206	Zebrafish
epithelial cell morphogenesis	GO:0003382	2	0.201
dorsal motor nucleus of vagus nerve development	GO:0021744	4	0.197
glial cell development	GO:0021782	20	0.196
phosphate containing compound metabolic process	GO:0006796	108	0.196	Human Yeast Mouse Worm
single organism localization	GO:1902578	225	0.192
cellular aromatic compound metabolic process	GO:0006725	295	0.191	Human Yeast
regulation of response to stimulus	GO:0048583	269	0.188
regulation of cell migration	GO:0030334	40	0.188	Zebrafish
cellular protein metabolic process	GO:0044267	129	0.187	Human Yeast Mouse Worm
sensory organ development	GO:0007423	393	0.185
organelle organization	GO:0006996	227	0.182
cell surface receptor signaling pathway	GO:0007166	325	0.179
regulation of eye photoreceptor cell development	GO:0042478	2	0.177
establishment or maintenance of apical basal cell polarity	GO:0035088	12	0.176
response to fluid shear stress	GO:0034405	2	0.174
endodermal cell fate determination	GO:0007493	2	0.171
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.171
cellular component disassembly	GO:0022411	1	0.169
transport	GO:0006810	220	0.167	Zebrafish Mouse Worm
gastrulation	GO:0007369	208	0.167
cell substrate adhesion	GO:0031589	4	0.165
septum transversum development	GO:0003343	4	0.161
liver development	GO:0001889	96	0.161
response to chemical	GO:0042221	320	0.160	Mouse
embryonic organ morphogenesis	GO:0048562	274	0.159
reproduction	GO:0000003	40	0.158	Worm
response to external stimulus	GO:0009605	264	0.156
regulation of multicellular organismal development	GO:2000026	223	0.155	Human Zebrafish Worm
cell migration involved in gastrulation	GO:0042074	79	0.155
protein modification process	GO:0036211	100	0.154	Human Yeast Mouse Worm
regulation of oligodendrocyte differentiation	GO:0048713	1	0.153
cell growth	GO:0016049	57	0.153
cell recognition	GO:0008037	19	0.152
cellular protein modification process	GO:0006464	100	0.152	Human Yeast Mouse Worm
regulation of rna biosynthetic process	GO:2001141	213	0.151	Human
maintenance of cell polarity	GO:0030011	5	0.150
aging	GO:0007568	2	0.150
nucleic acid templated transcription	GO:0097659	181	0.150	Human
regulation of biosynthetic process	GO:0009889	250	0.150	Human
retinal ganglion cell axon guidance	GO:0031290	35	0.149
head development	GO:0060322	303	0.148
anterior posterior pattern specification	GO:0009952	152	0.148
regulation of neuron projection development	GO:0010975	40	0.146	Human
nucleic acid metabolic process	GO:0090304	244	0.145	Human Yeast
brain development	GO:0007420	293	0.144
calcium dependent cell cell adhesion via plasma membrane cell adhesion molecules	GO:0016339	2	0.143
negative regulation of cellular process	GO:0048523	283	0.143	Human Zebrafish
regulation of myotube differentiation	GO:0010830	2	0.142
regulation of intracellular signal transduction	GO:1902531	57	0.139
posttranscriptional gene silencing	GO:0016441	3	0.136
protein metabolic process	GO:0019538	183	0.135	Human Yeast Mouse Worm
cellular response to endogenous stimulus	GO:0071495	68	0.130	Mouse
cellular component biogenesis	GO:0044085	178	0.130	Yeast
cilium organization	GO:0044782	71	0.126
regulation of metabolic process	GO:0019222	359	0.124	Human Yeast
specification of axis polarity	GO:0065001	4	0.120
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.120
determination of heart left right asymmetry	GO:0061371	117	0.119
notch signaling pathway	GO:0007219	35	0.119
stem cell proliferation	GO:0072089	4	0.119
regulation of signaling	GO:0023051	235	0.116
cell cell adhesion involved in mesendodermal cell migration	GO:0003370	1	0.116
establishment of epithelial cell apical basal polarity	GO:0045198	2	0.114
mitotic cell cycle	GO:0000278	64	0.112
macromolecular complex subunit organization	GO:0043933	74	0.112	Yeast Mouse
gland development	GO:0048732	143	0.112
pigmentation	GO:0043473	85	0.111
cellular localization	GO:0051641	97	0.110
negative regulation of calcium dependent cell cell adhesion	GO:0046588	1	0.110
regulation of localization	GO:0032879	104	0.109	Zebrafish Mouse
retina morphogenesis in camera type eye	GO:0060042	79	0.109
positive regulation of signal transduction	GO:0009967	56	0.109
blood vessel development	GO:0001568	246	0.108	Zebrafish
venous blood vessel morphogenesis	GO:0048845	3	0.108
regulation of locomotion	GO:0040012	55	0.108	Zebrafish
cellular macromolecule metabolic process	GO:0044260	391	0.108	Human Yeast Mouse Worm
regulation of multicellular organismal process	GO:0051239	277	0.108	Human Zebrafish Worm
developmental growth	GO:0048589	166	0.108
muscle cell differentiation	GO:0042692	139	0.107
stem cell division	GO:0017145	1	0.106
meiotic spindle organization	GO:0000212	1	0.105
neuroblast proliferation	GO:0007405	2	0.105
regulation of catalytic activity	GO:0050790	55	0.102
axon development	GO:0061564	166	0.101
modification dependent protein catabolic process	GO:0019941	3	0.100
macromolecule biosynthetic process	GO:0009059	227	0.099	Human
regulation of neural precursor cell proliferation	GO:2000177	3	0.098
striated muscle tissue development	GO:0014706	110	0.098
endodermal digestive tract morphogenesis	GO:0061031	2	0.098
proteasomal protein catabolic process	GO:0010498	2	0.098
axon extension	GO:0048675	45	0.097
homeostatic process	GO:0042592	142	0.095
meiosis i	GO:0007127	1	0.093
mitotic cell cycle embryonic	GO:0045448	2	0.092
immune system process	GO:0002376	241	0.090	Zebrafish
positive regulation of cell adhesion	GO:0045785	1	0.090
response to organic substance	GO:0010033	153	0.090	Mouse
regulation of wnt signaling pathway	GO:0030111	53	0.090
morphogenesis of an epithelial sheet	GO:0002011	49	0.090
heterocycle biosynthetic process	GO:0018130	215	0.089	Human
cellular component assembly	GO:0022607	170	0.089	Yeast
protein complex subunit organization	GO:0071822	46	0.089	Yeast Mouse
digestive system development	GO:0055123	289	0.088
cell adhesion	GO:0007155	40	0.088
transcription dna templated	GO:0006351	181	0.087	Human
primary neural tube formation	GO:0014020	1	0.085
regulation of photoreceptor cell differentiation	GO:0046532	2	0.085
phagocytosis	GO:0006909	3	0.084
positive regulation of cellular component biogenesis	GO:0044089	3	0.083
regulation of axonogenesis	GO:0050770	32	0.083
eye morphogenesis	GO:0048592	144	0.083
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.082
spindle assembly	GO:0051225	2	0.082
programmed cell death	GO:0012501	119	0.081	Human Zebrafish
cellular macromolecule biosynthetic process	GO:0034645	224	0.081	Human
positive regulation of cell substrate adhesion	GO:0010811	1	0.081
segmentation	GO:0035282	97	0.079
nucleobase containing compound biosynthetic process	GO:0034654	205	0.078	Human
positive regulation of cellular catabolic process	GO:0031331	3	0.076
regulation of neurogenesis	GO:0050767	87	0.076	Human
epithelial tube morphogenesis	GO:0060562	148	0.076
biological adhesion	GO:0022610	40	0.076
cell cycle	GO:0007049	93	0.075
mesenchyme development	GO:0060485	127	0.075
regulation of phosphorus metabolic process	GO:0051174	43	0.074
cardiac atrium development	GO:0003230	4	0.074
dorsal ventral pattern formation	GO:0009953	125	0.073
regulation of transcription dna templated	GO:0006355	213	0.072	Human
aromatic compound biosynthetic process	GO:0019438	217	0.072	Human
epiboly	GO:0090504	41	0.071
formation of primary germ layer	GO:0001704	62	0.070
positive regulation of transport	GO:0051050	2	0.070	Zebrafish Mouse
neuron projection extension	GO:1990138	45	0.068
epiboly involved in gastrulation with mouth forming second	GO:0055113	35	0.068
nuclear transport	GO:0051169	4	0.067
neural tube formation	GO:0001841	16	0.067
regulation of cell shape	GO:0008360	1	0.066
hindbrain development	GO:0030902	91	0.066
polarized epithelial cell differentiation	GO:0030859	4	0.065
regulation of canonical wnt signaling pathway	GO:0060828	34	0.065
homophilic cell adhesion via plasma membrane adhesion molecules	GO:0007156	4	0.065
muscle structure development	GO:0061061	196	0.065
transcription from rna polymerase ii promoter	GO:0006366	80	0.064
single organism cell adhesion	GO:0098602	29	0.064
nucleocytoplasmic transport	GO:0006913	4	0.064
microtubule based process	GO:0007017	60	0.064
skin development	GO:0043588	54	0.064
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.063
negative regulation of biological process	GO:0048519	304	0.063	Human Zebrafish Worm
single organism metabolic process	GO:0044710	217	0.063	Yeast
positive regulation of signaling	GO:0023056	56	0.062
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.062
regulation of programmed cell death	GO:0043067	101	0.061	Human Zebrafish
regulation of cell projection organization	GO:0031344	44	0.061	Human
regulation of cell communication	GO:0010646	232	0.061
axis elongation involved in somitogenesis	GO:0090245	2	0.061
response to light stimulus	GO:0009416	46	0.060
regulation of stem cell proliferation	GO:0072091	2	0.060
neuron migration	GO:0001764	22	0.059
negative regulation of cell motility	GO:2000146	17	0.059
organic cyclic compound metabolic process	GO:1901360	301	0.059	Human Yeast
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.059
regulation of organ morphogenesis	GO:2000027	35	0.058
organic substance catabolic process	GO:1901575	28	0.058	Yeast
regulation of epithelial cell proliferation	GO:0050678	3	0.057
cellular protein catabolic process	GO:0044257	4	0.057
aorta development	GO:0035904	4	0.057
negative regulation of transcription dna templated	GO:0045892	45	0.056
forebrain development	GO:0030900	96	0.056
tissue regeneration	GO:0042246	74	0.056
actomyosin structure organization	GO:0031032	53	0.056
female gamete generation	GO:0007292	14	0.056
regulation of cell motility	GO:2000145	46	0.056	Zebrafish
neuron projection guidance	GO:0097485	86	0.055
negative regulation of epithelial cell migration	GO:0010633	1	0.055
stem cell fate commitment	GO:0048865	1	0.055
left right pattern formation	GO:0060972	19	0.054
cell death in response to oxidative stress	GO:0036473	2	0.054
endocytosis	GO:0006897	16	0.054	Worm
embryonic epithelial tube formation	GO:0001838	17	0.053
negative regulation of cellular component movement	GO:0051271	18	0.053
stem cell differentiation	GO:0048863	117	0.053
germ cell development	GO:0007281	22	0.052
defense response to fungus	GO:0050832	2	0.052
adherens junction organization	GO:0034332	4	0.052
establishment of apical basal cell polarity	GO:0035089	2	0.052	Mouse
photoreceptor cell differentiation	GO:0046530	55	0.052	Mouse
macromolecule localization	GO:0033036	54	0.052	Mouse Worm
growth	GO:0040007	174	0.052
regulation of phosphorylation	GO:0042325	26	0.052
meiotic cell cycle process	GO:1903046	3	0.052
mesenchymal cell development	GO:0014031	78	0.051
neural nucleus development	GO:0048857	15	0.051
ectoderm development	GO:0007398	9	0.050
determination of left right asymmetry in nervous system	GO:0035545	4	0.050
negative regulation of cell migration	GO:0030336	17	0.049
positive regulation of metabolic process	GO:0009893	108	0.049
negative regulation of gene expression	GO:0010629	65	0.049
nephron epithelium morphogenesis	GO:0072088	1	0.049
negative regulation of signaling	GO:0023057	96	0.048
response to growth factor	GO:0070848	39	0.048
pronuclear migration	GO:0035046	1	0.048
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.048
central nervous system formation	GO:0021556	1	0.048
negative regulation of signal transduction	GO:0009968	94	0.048
posttranscriptional regulation of gene expression	GO:0010608	14	0.048
cellular ketone metabolic process	GO:0042180	11	0.047
regulation of primary metabolic process	GO:0080090	311	0.047	Human Yeast
inner ear development	GO:0048839	126	0.047
positive regulation of cell cycle	GO:0045787	3	0.047
endothelial cell development	GO:0001885	12	0.046
system process	GO:0003008	185	0.045
macromolecule modification	GO:0043412	111	0.045	Human Yeast Mouse Worm
regulation of cysteine type endopeptidase activity	GO:2000116	21	0.045
cellular response to chemical stimulus	GO:0070887	157	0.045	Mouse
neurological system process	GO:0050877	62	0.045
cell death	GO:0008219	121	0.044	Human Zebrafish
negative regulation of epithelial cell proliferation	GO:0050680	1	0.044
regulation of cellular component size	GO:0032535	30	0.044
mitotic dna integrity checkpoint	GO:0044774	4	0.044
intestinal epithelial cell differentiation	GO:0060575	3	0.044
oogenesis	GO:0048477	14	0.044
positive regulation of cell communication	GO:0010647	56	0.043
endoderm development	GO:0007492	49	0.043
positive regulation of neurogenesis	GO:0050769	24	0.043	Human
homeostasis of number of cells within a tissue	GO:0048873	4	0.043
cytokinesis	GO:0000910	3	0.043
negative regulation of cell communication	GO:0010648	96	0.043
posterior lateral line development	GO:0048916	38	0.043
convergent extension	GO:0060026	118	0.043
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	3	0.043
positive regulation of oligodendrocyte differentiation	GO:0048714	1	0.043
morphogenesis of follicular epithelium	GO:0016333	1	0.043
regulation of multicellular organism growth	GO:0040014	4	0.042
regulation of phosphate metabolic process	GO:0019220	43	0.042
pronephros development	GO:0048793	69	0.042
cellular amine metabolic process	GO:0044106	2	0.042
positive regulation of catabolic process	GO:0009896	4	0.042
amine metabolic process	GO:0009308	2	0.042
determination of left right asymmetry in diencephalon	GO:0035462	4	0.041
positive regulation of response to stimulus	GO:0048584	80	0.041
fertilization	GO:0009566	3	0.041
positive regulation of developmental process	GO:0051094	50	0.041	Human
regulation of anatomical structure size	GO:0090066	33	0.041
negative regulation of locomotion	GO:0040013	18	0.041
peripheral nervous system development	GO:0007422	55	0.041
regulation of cellular amine metabolic process	GO:0033238	0	0.041
death	GO:0016265	121	0.041	Human Zebrafish
regulation of cellular amino acid metabolic process	GO:0006521	0	0.040
foregut morphogenesis	GO:0007440	4	0.040
intracellular signal transduction	GO:0035556	85	0.040	Yeast
nerve development	GO:0021675	45	0.040
spinal cord dorsal ventral patterning	GO:0021513	5	0.040
endocardial cushion development	GO:0003197	6	0.039
regulation of erk1 and erk2 cascade	GO:0070372	4	0.039
chromosome segregation	GO:0007059	12	0.039
positive regulation of transcription dna templated	GO:0045893	57	0.039
regulation of protein binding	GO:0043393	3	0.038
muscle cell development	GO:0055001	115	0.038
anterior posterior axis specification	GO:0009948	20	0.038
response to uv	GO:0009411	3	0.038
regulation of protein catabolic process	GO:0042176	1	0.037
cellular response to growth factor stimulus	GO:0071363	39	0.037
stem cell maintenance	GO:0019827	4	0.037
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	2	0.037
regulation of tube size	GO:0035150	2	0.037
negative regulation of neural precursor cell proliferation	GO:2000178	1	0.036
determination of bilateral symmetry	GO:0009855	204	0.036
cell aging	GO:0007569	2	0.036
positive regulation of cell development	GO:0010720	25	0.036	Human
ventral spinal cord interneuron specification	GO:0021521	3	0.036
regulation of dendrite development	GO:0050773	3	0.036
regulation of axon extension	GO:0030516	24	0.036
negative regulation of macromolecule metabolic process	GO:0010605	76	0.036
ras protein signal transduction	GO:0007265	7	0.036
regulation of cellular protein metabolic process	GO:0032268	52	0.035
rna metabolic process	GO:0016070	219	0.035	Human Yeast
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.035
cellular response to organic substance	GO:0071310	105	0.035	Mouse
regulation of cell substrate adhesion	GO:0010810	1	0.034
phosphorylation	GO:0016310	69	0.034	Human Yeast Mouse Worm
desmosome assembly	GO:0002159	2	0.034
single fertilization	GO:0007338	3	0.034
positive regulation of chromatin modification	GO:1903310	1	0.034
response to external biotic stimulus	GO:0043207	97	0.034
melanin biosynthetic process	GO:0042438	1	0.034
neural tube patterning	GO:0021532	33	0.034
extrinsic apoptotic signaling pathway	GO:0097191	3	0.034
endocardial cushion formation	GO:0003272	2	0.034
hemopoiesis	GO:0030097	183	0.034	Zebrafish
intracellular transport	GO:0046907	32	0.034
spindle organization	GO:0007051	5	0.033
axon guidance	GO:0007411	86	0.033
adult behavior	GO:0030534	2	0.033
heterocycle metabolic process	GO:0046483	290	0.033	Human Yeast
canonical wnt signaling pathway	GO:0060070	48	0.033
regulation of gene expression epigenetic	GO:0040029	11	0.033
negative regulation of autophagy	GO:0010507	1	0.033
regulation of glial cell differentiation	GO:0045685	4	0.033
regulation of symbiosis encompassing mutualism through parasitism	GO:0043903	1	0.032
eye photoreceptor cell development	GO:0042462	30	0.032	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.032
axis specification	GO:0009798	43	0.032
positive regulation of glial cell differentiation	GO:0045687	1	0.032
positive regulation of neuron death	GO:1901216	1	0.032
gene silencing by rna	GO:0031047	4	0.032
symbiosis encompassing mutualism through parasitism	GO:0044403	4	0.032
positive regulation of nervous system development	GO:0051962	25	0.032	Human
macromolecular complex assembly	GO:0065003	35	0.032	Yeast
embryonic pectoral fin morphogenesis	GO:0035118	24	0.032
actin filament organization	GO:0007015	15	0.032	Yeast Mouse
striated muscle cell differentiation	GO:0051146	129	0.032
regulation of biomineral tissue development	GO:0070167	2	0.032
cellular response to external stimulus	GO:0071496	2	0.031
regulation of dendrite morphogenesis	GO:0048814	3	0.031
convergent extension involved in gastrulation	GO:0060027	71	0.031
organic cyclic compound biosynthetic process	GO:1901362	223	0.031	Human
regulation of cell adhesion	GO:0030155	15	0.031
endocardial cushion morphogenesis	GO:0003203	3	0.031
epidermis development	GO:0008544	48	0.031
interspecies interaction between organisms	GO:0044419	4	0.031
midbrain development	GO:0030901	28	0.031
connective tissue development	GO:0061448	99	0.031
single organism reproductive process	GO:0044702	40	0.030	Worm
cell junction organization	GO:0034330	11	0.030
dorsal convergence	GO:0060030	14	0.030
regulation of cell size	GO:0008361	29	0.030
positive regulation of rna biosynthetic process	GO:1902680	57	0.030
lateral line system development	GO:0048925	76	0.030
embryonic heart tube left right pattern formation	GO:0060971	5	0.030
anatomical structure homeostasis	GO:0060249	36	0.030
cellular amino acid metabolic process	GO:0006520	7	0.030
regulation of oxidative stress induced cell death	GO:1903201	2	0.030
regulation of growth	GO:0040008	42	0.030
negative regulation of cell cell adhesion	GO:0022408	6	0.029
regulation of cell cell adhesion	GO:0022407	13	0.029
erk1 and erk2 cascade	GO:0070371	4	0.029
negative regulation of rna biosynthetic process	GO:1902679	45	0.029
homeostasis of number of cells	GO:0048872	62	0.029
protein complex localization	GO:0031503	1	0.029
positive regulation of neuron apoptotic process	GO:0043525	1	0.029
spindle assembly involved in meiosis	GO:0090306	1	0.028
positive regulation of epithelial cell migration	GO:0010634	2	0.028
tissue migration	GO:0090130	37	0.028
gastrulation with mouth forming second	GO:0001702	44	0.028
cortical actin cytoskeleton organization	GO:0030866	1	0.028
neural tube development	GO:0021915	62	0.028
protein acylation	GO:0043543	3	0.028
regulation of transcription from rna polymerase ii promoter in response to oxidative stress	GO:0043619	0	0.027
nuclear division	GO:0000280	23	0.027
regulation of protein metabolic process	GO:0051246	56	0.027
mesoderm formation	GO:0001707	43	0.027
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.027
cellular response to hypoxia	GO:0071456	1	0.027
leukocyte migration	GO:0050900	15	0.027
aorta morphogenesis	GO:0035909	3	0.026
regulation of purine nucleotide catabolic process	GO:0033121	2	0.026
cell migration involved in heart development	GO:0060973	22	0.026
regulation of establishment of protein localization	GO:0070201	4	0.026	Mouse
embryonic pattern specification	GO:0009880	44	0.026
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.026
epithelial to mesenchymal transition	GO:0001837	21	0.026
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.026
cellular response to extracellular stimulus	GO:0031668	2	0.026
regulation of cellular ketone metabolic process	GO:0010565	7	0.026
somatic stem cell maintenance	GO:0035019	1	0.026
microtubule cytoskeleton organization	GO:0000226	33	0.026
extracellular structure organization	GO:0043062	27	0.026
regulation of establishment or maintenance of cell polarity	GO:0032878	2	0.025
organelle fission	GO:0048285	23	0.025
cell cell junction organization	GO:0045216	10	0.025
regulation of protein transport	GO:0051223	3	0.025
hematopoietic or lymphoid organ development	GO:0048534	191	0.025	Zebrafish
regulation of vesicle mediated transport	GO:0060627	9	0.025
keratinocyte differentiation	GO:0030216	0	0.025
cell matrix adhesion	GO:0007160	4	0.025
reciprocal meiotic recombination	GO:0007131	1	0.025
regulation of cell death	GO:0010941	103	0.025	Human Zebrafish
regulation of mitotic cell cycle	GO:0007346	25	0.025
pigment cell development	GO:0070285	3	0.025
mitotic nuclear division	GO:0007067	18	0.025
positive regulation of gliogenesis	GO:0014015	2	0.025	Human
neural crest cell migration	GO:0001755	42	0.024
regulation of chromatin organization	GO:1902275	5	0.024
adherens junction maintenance	GO:0034334	2	0.024
ubiquitin dependent protein catabolic process	GO:0006511	3	0.024
cell substrate junction assembly	GO:0007044	2	0.024
organonitrogen compound metabolic process	GO:1901564	74	0.024

prkci disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
organ system cancer	DOID:0050686	0.088
disease of cellular proliferation	DOID:14566	0.088
cancer	DOID:162	0.088
thoracic cancer	DOID:5093	0.077
breast cancer	DOID:1612	0.060

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