Danio rerio

61 known processes

dab2

disabled homolog 2 (Drosophila)

(Aliases: sb:cb778,zgc:77136)

dab2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
vasculature developmentGO:00019442780.707
blood vessel morphogenesisGO:00485142160.621
hematopoietic or lymphoid organ developmentGO:00485341910.559
Mouse
blood vessel developmentGO:00015682460.356
angiogenesisGO:00015251580.229
adherens junction organizationGO:003433240.197
immune system developmentGO:00025201910.186
Mouse
hemopoiesisGO:00300971830.169
Mouse
myeloid cell differentiationGO:0030099860.132
Mouse
response to drugGO:004249330.123
regulation of signalingGO:00230512350.119
immune responseGO:0006955280.118
response to stressGO:00069502630.115
Mouse
synaptic vesicle transportGO:004848910.115
regulation of endothelial cell proliferationGO:000193610.115
heart developmentGO:00075073130.110
regulation of neurotransmitter transportGO:005158810.107
embryonic organ developmentGO:00485683810.105
positive regulation of endothelial cell proliferationGO:000193810.098
anion transportGO:0006820380.092
signal transductionGO:00071654550.083
tube morphogenesisGO:00352393490.081
regulation of cell substrate adhesionGO:001081010.080
Mouse
nitrogen compound metabolic processGO:00068073190.078
Human Mouse
osteoclast developmentGO:003603510.077
positive regulation of cell substrate adhesionGO:001081110.071
Mouse
regulation of developmental processGO:00507932470.070
Human Mouse
immune system processGO:00023762410.069
Mouse
negative regulation of biological processGO:00485193040.067
Human Mouse
cellular component assemblyGO:00226071700.064
Mouse
endothelial cell proliferationGO:0001935110.064
ion transportGO:00068111140.063
positive regulation of transportGO:005105020.063
Human Mouse
generation of neuronsGO:00486993850.062
embryonic heart tube developmentGO:00350501330.061
camera type eye developmentGO:00430102220.061
cell surface receptor signaling pathwayGO:00071663250.061
carboxylic acid metabolic processGO:0019752220.060
embryonic hemopoiesisGO:0035162530.058
localization of cellGO:00516742440.057
Human Mouse Worm
positive regulation of map kinase activityGO:004340630.055
Mouse
organic anion transportGO:0015711150.054
lymph vessel developmentGO:0001945270.053
homeostatic processGO:00425921420.052
regulation of multicellular organismal processGO:00512392770.051
Human Mouse
positive regulation of macrophage chemotaxisGO:001075910.051
amine metabolic processGO:000930820.050
synaptic growth at neuromuscular junctionGO:005112420.049
regulation of cell matrix adhesionGO:000195210.048
renal absorptionGO:007029310.047
response to monosaccharideGO:003428430.047
cellular amine metabolic processGO:004410620.047
gas transportGO:001566930.046
positive regulation of cell matrix adhesionGO:000195410.046
regulation of multicellular organismal developmentGO:20000262230.046
Human Mouse
synaptic vesicle localizationGO:009747910.045
positive regulation of erk1 and erk2 cascadeGO:007037420.045
response to carbohydrateGO:000974330.045
single organism metabolic processGO:00447102170.044
Mouse
digestive tract morphogenesisGO:00485462310.044
neuron developmentGO:00486662620.044
regulation of erk1 and erk2 cascadeGO:007037240.044
sprouting angiogenesisGO:0002040530.042
oxoacid metabolic processGO:0043436310.042
cell motilityGO:00488702440.042
Human Mouse Worm
organic acid metabolic processGO:0006082310.041
cellular component morphogenesisGO:00329893360.040
Human Mouse
cell morphogenesisGO:00009022890.040
Human Mouse
hypothalamus cell differentiationGO:002197940.040
cell projection organizationGO:00300302840.040
establishment of localizationGO:00512342440.039
chemical homeostasisGO:0048878490.039
regulation of intracellular signal transductionGO:1902531570.038
Mouse
cellular nitrogen compound metabolic processGO:00346412900.037
Human Mouse
heterocycle biosynthetic processGO:00181302150.037
Human Mouse
tissue remodelingGO:004877140.037
regulation of biological qualityGO:00650082630.037
single organism transportGO:00447652060.036
Human Worm
macrophage chemotaxisGO:004824630.036
regulation of retina development in camera type eyeGO:190286620.036
regulation of cytokine productionGO:000181730.035
neuroblast proliferationGO:000740520.035
epithelial cell differentiationGO:00308551160.035
Human
cellular amino acid metabolic processGO:000652070.034
cellular component biogenesisGO:00440851780.034
Mouse
cell migrationGO:00164772370.033
Human Mouse Worm
regulation of programmed cell deathGO:00430671010.033
Human Mouse
positive regulation of stress activated mapk cascadeGO:003287430.033
Mouse
regulation of cytoplasmic transportGO:190364940.032
Human
positive regulation of cellular component movementGO:0051272110.032
Human Mouse
regulation of protein metabolic processGO:0051246560.032
Human Mouse
morphogenesis of an epitheliumGO:00020093330.032
negative regulation of programmed cell deathGO:0043069580.032
Human Mouse
regulation of intracellular protein transportGO:003315730.031
Human
epithelial cell developmentGO:0002064420.031
meiosis iiGO:000713510.031
synaptic vesicle recyclingGO:003646510.031
response to external stimulusGO:00096052640.031
negative regulation of cell communicationGO:0010648960.031
Human Mouse
eye developmentGO:00016542770.030
microglia differentiationGO:001400410.030
positive regulation of epithelial cell migrationGO:001063420.030
regulation of neural retina developmentGO:006107420.030
positive regulation of multicellular organismal processGO:0051240520.029
Human Mouse
response to woundingGO:00096111160.029
sensory organ morphogenesisGO:00905962000.029
regulation of mononuclear cell migrationGO:007167510.029
positive regulation of biological processGO:00485182530.029
Human Mouse Worm
synaptic vesicle endocytosisGO:004848810.029
system processGO:00030081850.029
Mouse
cellular component movementGO:00069283350.029
Human Mouse Worm
regulation of cellular amine metabolic processGO:003323800.029
digestive tract developmentGO:00485652650.028
homeostasis of number of cellsGO:0048872620.028
response to chemicalGO:00422213200.028
Human Mouse
negative regulation of response to stimulusGO:00485851040.028
Human Mouse
monovalent inorganic cation transportGO:0015672420.028
xenobiotic metabolic processGO:000680540.028
cell junction maintenanceGO:003433120.028
positive regulation of endothelial cell migrationGO:001059520.027
organic cyclic compound metabolic processGO:19013603010.027
Human Mouse
response to organic substanceGO:00100331530.027
Human Mouse
regulation of localizationGO:00328791040.027
Human Mouse
cellular response to external stimulusGO:007149620.027
cellular nitrogen compound biosynthetic processGO:00442712180.027
Human Mouse
stem cell proliferationGO:007208940.027
tissue homeostasisGO:0001894250.026
regulation of protein transportGO:005122330.026
Human
regulation of lymphangiogenesisGO:190149040.026
vesicle localizationGO:0051648270.026
tissue migrationGO:0090130370.026
regulation of cellular biosynthetic processGO:00313262450.026
response to biotic stimulusGO:0009607970.025
regulation of molecular functionGO:0065009700.025
Human Mouse
positive regulation of cellular component biogenesisGO:004408930.025
epithelial cell migrationGO:0010631250.025
regulation of vasculogenesisGO:200121210.025
amino acid transportGO:000686520.025
regulation of immune system processGO:0002682340.024
regulation of anatomical structure morphogenesisGO:00226031300.024
Human Mouse
regulation of nitrogen compound metabolic processGO:00511712510.024
anatomical structure homeostasisGO:0060249360.024
erythrocyte differentiationGO:0030218540.024
positive regulation of stem cell proliferationGO:200064810.024
multicellular organismal homeostasisGO:0048871290.023
cell aggregationGO:009874330.023
response to glucoseGO:000974930.023
nuclear transportGO:005116940.023
Human
iron ion homeostasisGO:005507240.023
ameboidal type cell migrationGO:00016671430.023
vasculogenesisGO:0001570410.023
single organism membrane fusionGO:004480120.023
axon developmentGO:00615641660.023
cation transportGO:0006812810.022
organonitrogen compound metabolic processGO:1901564740.022
innate immune responseGO:0045087130.022
erk1 and erk2 cascadeGO:007037140.022
apoptotic processGO:00069151160.022
Human Mouse
cytokinesisGO:000091030.022
cell part morphogenesisGO:00329902460.022
regulation of cellular component movementGO:0051270550.022
Human Mouse
membrane fusionGO:006102520.022
agingGO:000756820.021
dicarboxylic acid transportGO:000683510.021
regulation of neurotransmitter secretionGO:004692810.021
biological adhesionGO:0022610400.021
Mouse
regulation of reproductive processGO:200024140.021
sensory organ developmentGO:00074233930.021
regulation of locomotionGO:0040012550.021
Human Mouse Worm
smooth muscle contractionGO:000693920.021
primitive hemopoiesisGO:0060215270.021
regulation of cellular amino acid metabolic processGO:000652100.021
negative regulation of protein complex assemblyGO:003133310.021
peptidyl serine phosphorylationGO:001810510.021
establishment of synaptic vesicle localizationGO:009748010.020
retina development in camera type eyeGO:00600411460.020
response to external biotic stimulusGO:0043207970.020
positive regulation of leukocyte chemotaxisGO:000269010.020
striated muscle tissue developmentGO:00147061100.020
positive regulation of cellular amine metabolic processGO:003324000.020
regulation of synapse organizationGO:005080730.020
cell adhesionGO:0007155400.020
Mouse
head developmentGO:00603223030.020
gene expressionGO:00104672520.020
Human Mouse
response to other organismGO:0051707970.020
regulation of cellular metabolic processGO:00313233200.020
regulation of establishment of protein localizationGO:007020140.020
Human
guanosine containing compound metabolic processGO:190106840.020
negative regulation of multicellular organismal processGO:0051241690.020
adherens junction maintenanceGO:003433420.019
rna localizationGO:000640340.019
lipid homeostasisGO:005508830.019
vascular endothelial growth factor signaling pathwayGO:003808430.019
positive regulation of cytoskeleton organizationGO:005149530.019
mitotic cell cycleGO:0000278640.019
regulation of cell activationGO:005086510.019
single organism membrane organizationGO:0044802200.019
Human Mouse
definitive hemopoiesisGO:0060216180.019
regulation of cell shapeGO:000836010.019
transportGO:00068102200.019
signal transduction in absence of ligandGO:003803410.019
gastrulationGO:00073692080.019
venous blood vessel developmentGO:006084190.019
venous endothelial cell migration involved in lymph vessel developmentGO:006085540.018
cellular protein modification processGO:00064641000.018
Human Mouse
autophagyGO:000691440.018
regulation of vasculature developmentGO:1901342330.018
brain developmentGO:00074202930.018
defense responseGO:0006952470.018
eye morphogenesisGO:00485921440.018
small molecule metabolic processGO:0044281770.018
regulation of signal transductionGO:00099662250.018
nucleocytoplasmic transportGO:000691340.018
Human
membrane lipid biosynthetic processGO:004646720.018
positive regulation of cell adhesionGO:004578510.018
Mouse
endothelial cell migrationGO:0043542190.018
biosynthetic processGO:00090582940.018
Human Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stressGO:004361900.018
pole plasm assemblyGO:000731540.018
hepaticobiliary system developmentGO:0061008980.018
regulation of peptidase activityGO:0052547230.017
regulation of metal ion transportGO:001095940.017
positive regulation of epithelial cell proliferationGO:005067910.017
cellular response to hormone stimulusGO:0032870390.017
negative regulation of cellular processGO:00485232830.017
Human Mouse
lipid metabolic processGO:0006629520.017
cell cycle g1 s phase transitionGO:004484310.017
phosphorus metabolic processGO:00067931090.017
Human Mouse
chordate embryonic developmentGO:00430092710.017
Mouse
regulation of cell differentiationGO:00455951420.017
Human Mouse
renal tubule morphogenesisGO:006133310.017
primitive erythrocyte differentiationGO:006031950.017
growthGO:00400071740.017
Worm
regulation of nucleocytoplasmic transportGO:004682220.017
Human
catechol containing compound metabolic processGO:000971220.017
positive regulation of secretionGO:005104710.016
regulation of synaptic plasticityGO:004816710.016
regulation of endopeptidase activityGO:0052548230.016
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.016
blood vessel endothelial cell proliferation involved in sprouting angiogenesisGO:000204340.016
embryo development ending in birth or egg hatchingGO:00097922710.016
Mouse Worm
negative regulation of developmental processGO:0051093650.016
cellular lipid metabolic processGO:0044255360.016
regulation of angiogenesisGO:0045765260.016
glucose importGO:004632320.016
proteolysisGO:0006508380.016
Human
ammonium transmembrane transportGO:007248820.016
ion homeostasisGO:0050801410.016
deathGO:00162651210.015
Human Mouse
lymph vessel morphogenesisGO:0036303250.015
organic cyclic compound biosynthetic processGO:19013622230.015
Human Mouse
negative regulation of signal transductionGO:0009968940.015
Human Mouse
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.015
regulation of epithelial cell proliferationGO:005067830.015
female sex differentiationGO:004666040.015
positive regulation of lipid metabolic processGO:004583410.015
exocytosisGO:000688710.015
transmembrane transportGO:00550851200.015
b cell activationGO:004211320.015
cell morphogenesis involved in differentiationGO:00009041950.015
Human Mouse
mesoderm developmentGO:0007498880.015
negative regulation of kinase activityGO:003367340.015
regulation of cell deathGO:00109411030.015
Human Mouse
intracellular transportGO:0046907320.015
Human
pigmentationGO:0043473850.015
sphingolipid biosynthetic processGO:003014820.015
positive regulation of molecular functionGO:0044093330.014
Mouse
regulation of cellular protein metabolic processGO:0032268520.014
Human Mouse
astrocyte differentiationGO:004870810.014
single organism localizationGO:19025782250.014
Human Mouse Worm
leukocyte chemotaxisGO:0030595120.014
lipid catabolic processGO:001604240.014
pericardium developmentGO:006003910.014
heart contractionGO:0060047710.014
xanthophore differentiationGO:005093630.014
macromolecule modificationGO:00434121110.014
Human Mouse
endocrine system developmentGO:0035270650.014
neurotransmitter transportGO:000683620.014
regulation of catalytic activityGO:0050790550.014
Mouse
regulation of cellular component organizationGO:0051128860.014
Human Mouse
regulation of cell developmentGO:00602841000.014
Human Mouse
negative regulation of apoptotic processGO:0043066550.014
Human Mouse
epithelium migrationGO:0090132250.014
anterior posterior pattern specificationGO:00099521520.014
blood vessel endothelial cell migrationGO:0043534180.014
melanocyte migrationGO:009732440.014
sodium ion transportGO:0006814240.014
neurotransmitter secretionGO:000726920.014
negative regulation of gene expressionGO:0010629650.013
Human
regulation of neural precursor cell proliferationGO:200017730.013
protein localization to nucleusGO:003450430.013
Human
positive regulation of cellular processGO:00485222010.013
Human Mouse
regulation of embryonic developmentGO:0045995470.013
positive regulation of leukocyte migrationGO:000268720.013
sulfur compound transportGO:007234830.013
regulation of protein import into nucleusGO:004230620.013
Human
organonitrogen compound biosynthetic processGO:1901566470.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
cell substrate junction assemblyGO:000704420.013
regulation of cellular ketone metabolic processGO:001056570.013
positive regulation of developmental processGO:0051094500.013
Human Mouse
cell cycle arrestGO:000705010.013
erythrocyte homeostasisGO:0034101550.013
peptidyl serine modificationGO:001820920.013
meiotic cell cycle processGO:190304630.013
positive regulation of retina development in camera type eyeGO:190286810.013
cellular response to chemical stimulusGO:00708871570.013
Human Mouse
neuron differentiationGO:00301823530.013
cofactor metabolic processGO:0051186150.013
antimicrobial humoral responseGO:001973020.013
g2 m transition of mitotic cell cycleGO:000008640.013
muscle system processGO:0003012200.013
cell cell signalingGO:0007267520.013
actin cytoskeleton organizationGO:0030036630.013
cellular response to organic substanceGO:00713101050.013
Human Mouse
ion transmembrane transportGO:0034220910.012
negative regulation of angiogenesisGO:001652570.012
locomotionGO:00400113130.012
Human Mouse Worm
positive regulation of neural retina developmentGO:006107510.012
pancreas developmentGO:0031016840.012
regulation of cysteine type endopeptidase activityGO:2000116210.012
lymphangiogenesisGO:0001946250.012
regulation of calcium mediated signalingGO:005084810.012
organic substance transportGO:0071702580.012
Human Worm
osteoclast differentiationGO:003031610.012
regulation of cell migration involved in sprouting angiogenesisGO:009004930.012
protein import into nucleusGO:000660630.012
Human
negative regulation of reproductive processGO:200024230.012
cellular response to dna damage stimulusGO:0006974240.012
cellular component maintenanceGO:004395430.012
behaviorGO:0007610740.012
Worm
cell type specific apoptotic processGO:0097285220.012
cell substrate adhesionGO:003158940.012
Mouse
glucose homeostasisGO:004259310.012
pigment cell differentiationGO:0050931380.012
cellular response to nutrient levelsGO:003166920.012
lymphocyte proliferationGO:004665110.012
phosphate containing compound metabolic processGO:00067961080.012
Human Mouse
cardiac atrium morphogenesisGO:000320920.012
regulation of muscle contractionGO:000693730.012
g1 s transition of mitotic cell cycleGO:000008210.012
regulation of phosphate metabolic processGO:0019220430.012
Human Mouse
regulation of hematopoietic progenitor cell differentiationGO:190153210.012
regulation of sequence specific dna binding transcription factor activityGO:005109090.012
renal system developmentGO:0072001940.011
guanosine containing compound catabolic processGO:190106920.011
negative regulation of macromolecule metabolic processGO:0010605760.011
Human
regulation of gene expressionGO:00104682650.011
negative regulation of intracellular transportGO:003238730.011
regulation of nucleobase containing compound metabolic processGO:00192192500.011
nucleobase containing compound metabolic processGO:00061392740.011
Human Mouse
ventricular cardiac muscle tissue developmentGO:000322930.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
Human Mouse
monoamine transportGO:001584410.011
regulation of phosphorus metabolic processGO:0051174430.011
Human Mouse
regulation of phosphorylationGO:0042325260.011
Human Mouse
positive regulation of secretion by cellGO:190353210.011
regulation of protein bindingGO:004339330.011
Human
tetrapyrrole metabolic processGO:0033013100.011
response to organic cyclic compoundGO:0014070510.011
carbon dioxide transportGO:001567030.011
cellular aromatic compound metabolic processGO:00067252950.011
Human Mouse
negative regulation of cytoplasmic transportGO:190365020.011
catecholamine metabolic processGO:000658420.011
protein importGO:001703830.011
Human
establishment of protein localization to organelleGO:007259440.011
Human
cell projection morphogenesisGO:00488582440.011
regulation of cellular macromolecule biosynthetic processGO:20001122220.011
regulation of photoreceptor cell differentiationGO:004653220.011
granulocyte chemotaxisGO:0071621110.011
urogenital system developmentGO:0001655970.011
organelle fusionGO:004828430.011
regulation of protein processingGO:0070613100.011
skeletal muscle organ developmentGO:0060538780.011
positive regulation of histone modificationGO:003105810.011
establishment of endothelial barrierGO:006102830.011
regulation of translational initiationGO:000644610.011
selective angioblast sproutingGO:003547450.011
central nervous system developmentGO:00074173870.011
regulation of cellular component biogenesisGO:0044087120.010
mononuclear cell migrationGO:007167410.010
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.010
regulation of protein complex assemblyGO:004325430.010
adherens junction assemblyGO:003433310.010
regulation of kinase activityGO:0043549150.010
Mouse
regulation of cardiac muscle tissue developmentGO:005502410.010
trabecula morphogenesisGO:006138320.010
mitotic metaphase plate congressionGO:000708010.010
wound healingGO:0042060900.010
positive regulation of cellular amino acid metabolic processGO:004576400.010
small molecule catabolic processGO:004428230.010
locomotory behaviorGO:0007626340.010
modification of morphology or physiology of other organismGO:003582140.010
response to endogenous stimulusGO:0009719830.010
Human Mouse
actin filament based movementGO:003004810.010
cell projection assemblyGO:0030031640.010
metal ion transportGO:0030001580.010
adrenal gland developmentGO:0030325100.010

dab2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.083
immune system diseaseDOID:291400.027
hematopoietic system diseaseDOID:7400.019
disease of cellular proliferationDOID:1456600.016
cancerDOID:16200.016
organ system cancerDOID:005068600.016
muscular diseaseDOID:008000000.013
musculoskeletal system diseaseDOID:1700.013
muscle tissue diseaseDOID:6600.013
disease of metabolismDOID:001466700.012