IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

cbx5

chromobox homolog 5 (HP1 alpha homolog, Drosophila)

(Aliases: zgc:158601,wu:fi03h05,wu:fc63e02,id:ibd2026,MGC158601,wu:fe47g12)

ZFIN: ZDB-GENE-030131-5553
Ensembl: ENSDARG00000061187
Entrez: 563396
UniProtKB: A1L223

Process Predictions
Disease Predictions

cbx5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
organic cyclic compound biosynthetic process	GO:1901362	223	0.762	Human Mouse Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.750	Human Mouse Fly
nucleic acid metabolic process	GO:0090304	244	0.683	Human Mouse Fly
heterocycle biosynthetic process	GO:0018130	215	0.605	Human Mouse Fly
organic substance biosynthetic process	GO:1901576	289	0.544	Human Mouse Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.528	Human Mouse Fly
larval development	GO:0002164	2	0.513	Worm
brain development	GO:0007420	293	0.479
regulation of macromolecule metabolic process	GO:0060255	317	0.468	Human Mouse Fly
transcription dna templated	GO:0006351	181	0.468	Human Mouse Fly
nucleic acid templated transcription	GO:0097659	181	0.457	Human Mouse Fly
histone modification	GO:0016570	20	0.441	Fly
regulation of rna biosynthetic process	GO:2001141	213	0.401	Human Mouse Fly
central nervous system development	GO:0007417	387	0.399
organic cyclic compound metabolic process	GO:1901360	301	0.382	Human Mouse Fly
biosynthetic process	GO:0009058	294	0.370	Human Mouse Fly
nitrogen compound metabolic process	GO:0006807	319	0.344	Human Mouse Fly
protein acylation	GO:0043543	3	0.341
gene expression	GO:0010467	252	0.331	Human Mouse Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.328	Human Mouse Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.312	Human Mouse Fly
cellular biosynthetic process	GO:0044249	286	0.308	Human Mouse Fly
positive regulation of cellular biosynthetic process	GO:0031328	68	0.298	Fly
cellular nitrogen compound metabolic process	GO:0034641	290	0.280	Human Mouse Fly
cellular macromolecule biosynthetic process	GO:0034645	224	0.276	Human Mouse Fly
transcription from rna polymerase ii promoter	GO:0006366	80	0.252	Fly
regulation of transcription dna templated	GO:0006355	213	0.245	Human Mouse Fly
chromatin modification	GO:0016568	21	0.231	Fly
regulation of gene expression	GO:0010468	265	0.231	Human Mouse Fly
rna metabolic process	GO:0016070	219	0.223	Human Mouse Fly
negative regulation of cellular process	GO:0048523	283	0.217	Human Mouse Worm Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.207	Human Mouse Fly
heterocycle metabolic process	GO:0046483	290	0.200	Human Mouse Fly
organelle organization	GO:0006996	227	0.192	Fly
rna biosynthetic process	GO:0032774	181	0.183	Human Mouse Fly
negative regulation of biological process	GO:0048519	304	0.178	Human Mouse Worm Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.175	Human Mouse Fly
aging	GO:0007568	2	0.163
regionalization	GO:0003002	274	0.160
regulation of biosynthetic process	GO:0009889	250	0.155	Human Mouse Fly
regulation of rna metabolic process	GO:0051252	224	0.151	Human Mouse Fly
regulation of cellular metabolic process	GO:0031323	320	0.150	Human Mouse Fly
negative regulation of rna biosynthetic process	GO:1902679	45	0.148	Human Mouse Fly
nuclear migration	GO:0007097	3	0.143
protein acetylation	GO:0006473	2	0.142
phagocytosis	GO:0006909	3	0.138
cellular component biogenesis	GO:0044085	178	0.134	Fly
regulation of metabolic process	GO:0019222	359	0.128	Human Mouse Fly
positive regulation of transcription dna templated	GO:0045893	57	0.126	Fly
negative regulation of cellular biosynthetic process	GO:0031327	55	0.126	Human Mouse Fly
positive regulation of biosynthetic process	GO:0009891	68	0.125	Fly
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.124	Fly
single organism organelle organization	GO:1902589	199	0.121	Fly
segmentation	GO:0035282	97	0.121
negative regulation of gene expression	GO:0010629	65	0.115	Human Mouse Fly
macromolecule biosynthetic process	GO:0009059	227	0.113	Human Mouse Fly
embryo development ending in birth or egg hatching	GO:0009792	271	0.112
peptidyl lysine acetylation	GO:0018394	2	0.111
cellular component morphogenesis	GO:0032989	336	0.110
chromosome organization	GO:0051276	31	0.110	Fly
regulation of multicellular organism growth	GO:0040014	4	0.106	Worm
positive regulation of rna biosynthetic process	GO:1902680	57	0.106	Fly
nuclear transport	GO:0051169	4	0.105
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.105
internal peptidyl lysine acetylation	GO:0018393	2	0.102
regulation of gene expression epigenetic	GO:0040029	11	0.102	Fly
digestive system development	GO:0055123	289	0.101
cellular ketone metabolic process	GO:0042180	11	0.100
cellular macromolecule metabolic process	GO:0044260	391	0.096	Human Mouse Fly
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.096	Human Mouse Fly
regulation of transcription elongation from rna polymerase ii promoter	GO:0034243	3	0.095
mitotic cell cycle embryonic	GO:0045448	2	0.093
positive regulation of cellular process	GO:0048522	201	0.092	Fly
positive regulation of metabolic process	GO:0009893	108	0.092	Fly
regulation of cellular biosynthetic process	GO:0031326	245	0.092	Human Mouse Fly
cellular aromatic compound metabolic process	GO:0006725	295	0.092	Human Mouse Fly
negative regulation of metabolic process	GO:0009892	86	0.091	Human Mouse Fly
positive regulation of biological process	GO:0048518	253	0.090	Worm Fly
histone methylation	GO:0016571	13	0.090	Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.083	Fly
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.083	Human Mouse Fly
aromatic compound biosynthetic process	GO:0019438	217	0.083	Human Mouse Fly
internal protein amino acid acetylation	GO:0006475	2	0.083
head development	GO:0060322	303	0.082
multicellular organism growth	GO:0035264	4	0.081	Worm
digestive tract development	GO:0048565	265	0.081
chemosensory behavior	GO:0007635	1	0.081	Worm
immune system development	GO:0002520	191	0.078
positive regulation of cellular carbohydrate metabolic process	GO:0010676	1	0.077
covalent chromatin modification	GO:0016569	20	0.077	Fly
nucleocytoplasmic transport	GO:0006913	4	0.076
positive regulation of rna metabolic process	GO:0051254	59	0.074	Fly
positive regulation of cellular metabolic process	GO:0031325	94	0.074	Fly
hematopoietic or lymphoid organ development	GO:0048534	191	0.073
cellular amino acid metabolic process	GO:0006520	7	0.071
regulation of primary metabolic process	GO:0080090	311	0.070	Human Mouse Fly
positive regulation of cellular amine metabolic process	GO:0033240	0	0.069
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.069	Human Mouse Fly
single organism reproductive process	GO:0044702	40	0.068	Worm
maintenance of location	GO:0051235	4	0.067
positive regulation of chromatin modification	GO:1903310	1	0.067	Fly
macromolecular complex subunit organization	GO:0043933	74	0.067	Fly
nucleus organization	GO:0006997	7	0.065
negative regulation of biosynthetic process	GO:0009890	55	0.065	Human Mouse Fly
cell death	GO:0008219	121	0.065	Worm Fly
hemopoiesis	GO:0030097	183	0.065
regulation of protein complex assembly	GO:0043254	3	0.065
positive regulation of carbohydrate metabolic process	GO:0045913	1	0.065
carboxylic acid metabolic process	GO:0019752	22	0.061
positive regulation of macromolecule metabolic process	GO:0010604	93	0.060	Fly
gene silencing	GO:0016458	4	0.059	Fly
transport	GO:0006810	220	0.058
cellular component disassembly	GO:0022411	1	0.057
actin filament based process	GO:0030029	64	0.057
cellular component assembly	GO:0022607	170	0.057	Fly
positive regulation of cellular component biogenesis	GO:0044089	3	0.056	Fly
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.055	Fly
meiotic nuclear division	GO:0007126	4	0.055
regulation of carbohydrate metabolic process	GO:0006109	4	0.052
cell cycle	GO:0007049	93	0.052
cell projection organization	GO:0030030	284	0.051
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.050	Fly
negative regulation of macromolecule metabolic process	GO:0010605	76	0.050	Human Mouse Fly
lateral inhibition	GO:0046331	1	0.049
chordate embryonic development	GO:0043009	271	0.049
macromolecular complex assembly	GO:0065003	35	0.049	Fly
small molecule metabolic process	GO:0044281	77	0.049
protein modification process	GO:0036211	100	0.048	Fly
regulation of response to stimulus	GO:0048583	269	0.047	Worm
peptidyl lysine dimethylation	GO:0018027	1	0.047	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.047	Human Mouse Fly
regulation of biological quality	GO:0065008	263	0.046	Fly
cytokinesis	GO:0000910	3	0.046
regulation of cell differentiation	GO:0045595	142	0.045	Worm
actin cytoskeleton organization	GO:0030036	63	0.043
homeostatic process	GO:0042592	142	0.043	Fly
immune system process	GO:0002376	241	0.043
negative regulation of dna metabolic process	GO:0051053	4	0.042	Fly
protein import	GO:0017038	3	0.042
negative regulation of cellular metabolic process	GO:0031324	77	0.041	Human Mouse Fly
regulation of signaling	GO:0023051	235	0.041	Worm
cognition	GO:0050890	1	0.040	Worm
mitotic cell cycle	GO:0000278	64	0.040
cellular amine metabolic process	GO:0044106	2	0.040
embryonic digestive tract morphogenesis	GO:0048557	3	0.039
heart development	GO:0007507	313	0.038
single organism metabolic process	GO:0044710	217	0.038	Fly
regulation of cellular amine metabolic process	GO:0033238	0	0.038
regulation of cellular amino acid metabolic process	GO:0006521	0	0.038
positive regulation of transport	GO:0051050	2	0.037
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.037	Human Mouse Fly
single organism localization	GO:1902578	225	0.037
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.036	Fly
multi organism process	GO:0051704	134	0.036	Worm
protein stabilization	GO:0050821	2	0.035
mitotic dna damage checkpoint	GO:0044773	4	0.035
actin polymerization or depolymerization	GO:0008154	2	0.034
generation of neurons	GO:0048699	385	0.034
regulation of establishment of protein localization	GO:0070201	4	0.034
protein localization to nucleus	GO:0034504	3	0.034
autophagy	GO:0006914	4	0.034
cellular protein modification process	GO:0006464	100	0.033	Fly
positive regulation of histone modification	GO:0031058	1	0.033	Fly
negative regulation of transcription dna templated	GO:0045892	45	0.033	Human Mouse Fly
histone h3 k9 modification	GO:0061647	5	0.033	Fly
regulation of programmed cell death	GO:0043067	101	0.032	Fly
single organism biosynthetic process	GO:0044711	71	0.032
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.031	Fly
locomotion	GO:0040011	313	0.031
organelle assembly	GO:0070925	110	0.031
skeletal system development	GO:0001501	181	0.031
positive regulation of transcription elongation from rna polymerase ii promoter	GO:0032968	1	0.031
embryonic digestive tract development	GO:0048566	4	0.031
dna metabolic process	GO:0006259	27	0.030	Fly
positive regulation of gene expression	GO:0010628	71	0.030	Fly
dna modification	GO:0006304	8	0.030	Fly
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.030	Human Mouse Fly
hindbrain development	GO:0030902	91	0.029
digestive tract morphogenesis	GO:0048546	231	0.029
regulation of developmental process	GO:0050793	247	0.029	Worm
response to ketone	GO:1901654	1	0.029
establishment of localization in cell	GO:0051649	77	0.029
protein import into nucleus	GO:0006606	3	0.028
methylation	GO:0032259	22	0.028	Fly
regulation of binding	GO:0051098	3	0.028
amine metabolic process	GO:0009308	2	0.027
chromatin organization	GO:0006325	22	0.027	Fly
anterior posterior pattern specification	GO:0009952	152	0.027
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.027
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.027	Human Mouse Fly
cellular protein metabolic process	GO:0044267	129	0.027	Fly
nuclear import	GO:0051170	3	0.027
regulation of signal transduction	GO:0009966	225	0.026	Worm
microtubule organizing center organization	GO:0031023	1	0.026
neural tube development	GO:0021915	62	0.026
regulation of dna templated transcription elongation	GO:0032784	3	0.026
regulation of cytoplasmic transport	GO:1903649	4	0.025
centrosome organization	GO:0051297	1	0.025
oxoacid metabolic process	GO:0043436	31	0.024
negative regulation of developmental process	GO:0051093	65	0.024	Worm
localization within membrane	GO:0051668	1	0.024
regulation of dna metabolic process	GO:0051052	11	0.023	Fly
embryonic organ development	GO:0048568	381	0.023
histone h3 k4 methylation	GO:0051568	2	0.023
macromolecule modification	GO:0043412	111	0.023	Fly
positive regulation of dna metabolic process	GO:0051054	1	0.023	Fly
negative regulation of rna metabolic process	GO:0051253	48	0.023	Human Mouse Fly
organic acid metabolic process	GO:0006082	31	0.023
cell aging	GO:0007569	2	0.022
cell morphogenesis	GO:0000902	289	0.022
protein targeting to nucleus	GO:0044744	3	0.022
cell fate specification	GO:0001708	68	0.022
cell migration involved in gastrulation	GO:0042074	79	0.022
cellular carbohydrate metabolic process	GO:0044262	4	0.022
neurological system process	GO:0050877	62	0.022	Worm
reproduction	GO:0000003	40	0.022	Worm
cell cycle arrest	GO:0007050	1	0.022
macromolecular complex disassembly	GO:0032984	1	0.022
cellular response to external stimulus	GO:0071496	2	0.021
dna catabolic process	GO:0006308	1	0.021
neuron differentiation	GO:0030182	353	0.021
protein metabolic process	GO:0019538	183	0.021	Fly
neuron development	GO:0048666	262	0.020
response to uv	GO:0009411	3	0.020
positive regulation of dna templated transcription elongation	GO:0032786	1	0.020
mitotic dna integrity checkpoint	GO:0044774	4	0.020
organonitrogen compound metabolic process	GO:1901564	74	0.019
striated muscle cell development	GO:0055002	108	0.019
protein complex disassembly	GO:0043241	1	0.019
regulation of histone modification	GO:0031056	5	0.018	Fly
cellular component assembly involved in morphogenesis	GO:0010927	107	0.018
mitotic cell cycle process	GO:1903047	48	0.018
muscle structure development	GO:0061061	196	0.018
nucleic acid transport	GO:0050657	2	0.018
cell part morphogenesis	GO:0032990	246	0.018
cell motility	GO:0048870	244	0.018
mitotic g2 dna damage checkpoint	GO:0007095	3	0.018
protein polymerization	GO:0051258	4	0.018
metencephalon development	GO:0022037	27	0.017
telomere organization	GO:0032200	1	0.017	Fly
growth	GO:0040007	174	0.017	Worm
protein complex localization	GO:0031503	1	0.017
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.017
g2 m transition of mitotic cell cycle	GO:0000086	4	0.016
blood vessel morphogenesis	GO:0048514	216	0.016
establishment of localization	GO:0051234	244	0.016
actin filament polymerization	GO:0030041	2	0.016
regulation of cell communication	GO:0010646	232	0.016	Worm
protein complex biogenesis	GO:0070271	30	0.016
cellular macromolecular complex assembly	GO:0034622	24	0.016
muscle cell differentiation	GO:0042692	139	0.016
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.016
signal transduction	GO:0007165	455	0.016	Worm
establishment of protein localization to organelle	GO:0072594	4	0.016
response to stress	GO:0006950	263	0.016
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.016	Worm
skin development	GO:0043588	54	0.015
positive regulation of protein complex assembly	GO:0031334	2	0.015
vasculature development	GO:0001944	278	0.015
tube morphogenesis	GO:0035239	349	0.015
regulation of carbohydrate biosynthetic process	GO:0043255	1	0.015
rna 3 end processing	GO:0031123	2	0.015
response to glucocorticoid	GO:0051384	1	0.015
muscle organ development	GO:0007517	101	0.015
carbohydrate biosynthetic process	GO:0016051	1	0.015
regulation of protein targeting	GO:1903533	2	0.015
meiotic cell cycle process	GO:1903046	3	0.015
response to chemical	GO:0042221	320	0.015	Worm
cytoskeleton organization	GO:0007010	96	0.015
muscle cell development	GO:0055001	115	0.014
rna localization	GO:0006403	4	0.014
convergent extension	GO:0060026	118	0.014
liver development	GO:0001889	96	0.014
single organism nuclear import	GO:1902593	3	0.014
peptidyl amino acid modification	GO:0018193	16	0.014	Fly
adult behavior	GO:0030534	2	0.014
transcription elongation from rna polymerase ii promoter	GO:0006368	3	0.014
protein k63 linked ubiquitination	GO:0070534	2	0.014
regulation of growth rate	GO:0040009	1	0.014	Worm
regulation of circadian rhythm	GO:0042752	4	0.014
developmental growth	GO:0048589	166	0.014	Worm
cell cycle process	GO:0022402	53	0.013
atp catabolic process	GO:0006200	4	0.013
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.013
establishment of rna localization	GO:0051236	3	0.013
negative regulation of cell projection organization	GO:0031345	9	0.013
regulation of growth	GO:0040008	42	0.013	Worm
protein complex subunit organization	GO:0071822	46	0.013
regulation of apoptotic process	GO:0042981	98	0.013	Fly
mrna transport	GO:0051028	2	0.013
negative regulation of signaling	GO:0023057	96	0.013	Worm
dna templated transcription elongation	GO:0006354	3	0.013
cellular response to extracellular stimulus	GO:0031668	2	0.013
circulatory system process	GO:0003013	87	0.013
regulation of cellular protein metabolic process	GO:0032268	52	0.013	Fly
meiosis i	GO:0007127	1	0.013
homeostasis of number of cells	GO:0048872	62	0.013
positive regulation of chromosome organization	GO:2001252	1	0.013	Fly
mitotic g2 m transition checkpoint	GO:0044818	3	0.012
regulation of cellular ketone metabolic process	GO:0010565	7	0.012
regulation of multicellular organismal process	GO:0051239	277	0.012	Worm
sex determination	GO:0007530	1	0.012
programmed cell death	GO:0012501	119	0.012	Worm Fly
morphogenesis of an epithelium	GO:0002009	333	0.012
response to wounding	GO:0009611	116	0.012
regulation of cell death	GO:0010941	103	0.012	Fly
single organism transport	GO:0044765	206	0.012
regulation of histone h3 k9 methylation	GO:0051570	2	0.012	Fly
embryonic organ morphogenesis	GO:0048562	274	0.012
death	GO:0016265	121	0.012	Worm Fly
somitogenesis	GO:0001756	87	0.012
cell cycle g2 m phase transition	GO:0044839	4	0.011
carbohydrate metabolic process	GO:0005975	12	0.011
cell migration	GO:0016477	237	0.011
negative regulation of response to stimulus	GO:0048585	104	0.011	Worm
embryonic pattern specification	GO:0009880	44	0.011
epidermis morphogenesis	GO:0048730	4	0.011
primary neural tube formation	GO:0014020	1	0.011
posttranscriptional gene silencing	GO:0016441	3	0.011
nuclear export	GO:0051168	1	0.011
regeneration	GO:0031099	91	0.011
regulation of protein polymerization	GO:0032271	2	0.011
gene silencing by rna	GO:0031047	4	0.011
regulation of nucleocytoplasmic transport	GO:0046822	2	0.011
double strand break repair	GO:0006302	3	0.011
regulation of protein transport	GO:0051223	3	0.011
membrane invagination	GO:0010324	1	0.011
phagocytosis engulfment	GO:0006911	1	0.011
striated muscle tissue development	GO:0014706	110	0.011
regulation of protein import into nucleus	GO:0042306	2	0.010
regulation of cytokine production	GO:0001817	3	0.010
organic cyclic compound catabolic process	GO:1901361	15	0.010
regulation of stem cell differentiation	GO:2000736	4	0.010
adherens junction organization	GO:0034332	4	0.010
peptidyl lysine modification	GO:0018205	5	0.010	Fly
cytoskeleton dependent cytokinesis	GO:0061640	3	0.010
organelle fission	GO:0048285	23	0.010
establishment of organelle localization	GO:0051656	45	0.010

cbx5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.043
diabetes mellitus	DOID:9351	0.013
glucose metabolism disease	DOID:4194	0.013
disease of metabolism	DOID:0014667	0.013
acquired metabolic disease	DOID:0060158	0.013
type 2 diabetes mellitus	DOID:9352	0.013
carbohydrate metabolism disease	DOID:0050013	0.013
nervous system disease	DOID:863	0.012
sensory system disease	DOID:0050155	0.011

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