Danio rerio

27 known processes

polb

polymerase (DNA directed), beta

(Aliases: MGC174347,wu:fa97a05,MGC194077,zgc:109924)

polb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.378
cellular aromatic compound metabolic processGO:00067252950.283
biosynthetic processGO:00090582940.279
cellular biosynthetic processGO:00442492860.247
nitrogen compound metabolic processGO:00068073190.241
cellular nitrogen compound metabolic processGO:00346412900.171
nucleobase containing compound metabolic processGO:00061392740.158
regulation of cellular biosynthetic processGO:00313262450.157
gene expressionGO:00104672520.157
macromolecule biosynthetic processGO:00090592270.156
organic substance biosynthetic processGO:19015762890.148
cellular response to lipopolysaccharideGO:007122230.142
meiotic nuclear divisionGO:000712640.140
response to chemicalGO:00422213200.139
Rat
cellular macromolecule metabolic processGO:00442603910.139
embryo development ending in birth or egg hatchingGO:00097922710.135
nucleic acid metabolic processGO:00903042440.132
signal transductionGO:00071654550.126
Mouse
digestive tract morphogenesisGO:00485462310.126
heterocycle biosynthetic processGO:00181302150.123
neuron differentiationGO:00301823530.123
regulation of rna metabolic processGO:00512522240.123
regulation of rna biosynthetic processGO:20011412130.122
cell motilityGO:00488702440.121
nucleic acid templated transcriptionGO:00976591810.120
rna biosynthetic processGO:00327741810.119
regulation of nucleobase containing compound metabolic processGO:00192192500.112
guanosine containing compound metabolic processGO:190106840.112
generation of neuronsGO:00486993850.110
response to stressGO:00069502630.107
Mouse Rat
cytokinesisGO:000091030.104
sensory organ developmentGO:00074233930.101
negative regulation of cellular processGO:00485232830.101
stem cell divisionGO:001714510.101
regulation of biosynthetic processGO:00098892500.100
mitochondrion organizationGO:000700540.099
regulation of nitrogen compound metabolic processGO:00511712510.098
nucleobase containing compound biosynthetic processGO:00346542050.096
digestive system developmentGO:00551232890.095
cellular macromolecule biosynthetic processGO:00346452240.092
regulation of cellular metabolic processGO:00313233200.091
regulation of gene expressionGO:00104682650.090
rna metabolic processGO:00160702190.089
maintenance of locationGO:005123540.089
modification dependent macromolecule catabolic processGO:004363230.087
regulation of macromolecule biosynthetic processGO:00105562250.087
ubiquitin dependent protein catabolic processGO:000651130.086
regulation of cellular macromolecule biosynthetic processGO:20001122220.082
cytoskeleton dependent cytokinesisGO:006164030.082
regulation of primary metabolic processGO:00800903110.081
chordate embryonic developmentGO:00430092710.081
aromatic compound biosynthetic processGO:00194382170.081
regulation of transcription from rna polymerase ii promoterGO:00063571140.080
proteolysis involved in cellular protein catabolic processGO:005160330.080
cellular nitrogen compound biosynthetic processGO:00442712180.080
positive regulation of apoptotic signaling pathwayGO:200123510.078
cell migrationGO:00164772370.078
regulation of macromolecule metabolic processGO:00602553170.077
transcription dna templatedGO:00063511810.077
regulation of metabolic processGO:00192223590.076
negative regulation of biological processGO:00485193040.076
heart developmentGO:00075073130.075
modification dependent protein catabolic processGO:001994130.075
locomotionGO:00400113130.074
organelle organizationGO:00069962270.073
organic cyclic compound biosynthetic processGO:19013622230.073
positive regulation of biological processGO:00485182530.073
establishment of localizationGO:00512342440.072
system processGO:00030081850.071
positive regulation of cellular processGO:00485222010.070
cellular component morphogenesisGO:00329893360.069
regulation of transcription dna templatedGO:00063552130.069
cell morphogenesisGO:00009022890.068
regulation of nucleotide catabolic processGO:003081120.067
neuron developmentGO:00486662620.067
regulation of cell communicationGO:00106462320.067
gastrulationGO:00073692080.066
positive regulation of transportGO:005105020.066
response to external stimulusGO:00096052640.066
positive regulation of stress activated mapk cascadeGO:003287430.065
regionalizationGO:00030022740.065
gtp catabolic processGO:000618420.064
proteasomal protein catabolic processGO:001049820.063
regulation of nucleic acid templated transcriptionGO:19035062130.061
dorsal ventral pattern formationGO:00099531250.059
digestive tract developmentGO:00485652650.058
regulation of purine nucleotide catabolic processGO:003312120.058
negative regulation of gene expressionGO:0010629650.057
regulation of protein complex assemblyGO:004325430.057
developmental growthGO:00485891660.056
regulation of developmental processGO:00507932470.056
vasculature developmentGO:00019442780.055
spindle assemblyGO:005122520.055
guanosine containing compound catabolic processGO:190106920.054
immune system processGO:00023762410.054
regulation of multicellular organismal processGO:00512392770.054
cellular component movementGO:00069283350.054
organic cyclic compound metabolic processGO:19013603010.054
single organism localizationGO:19025782250.053
cellular protein catabolic processGO:004425740.053
meiotic cell cycle processGO:190304630.053
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.053
sensory organ morphogenesisGO:00905962000.053
agingGO:000756820.052
Rat
fatty acid biosynthetic processGO:000663340.052
purine ribonucleoside monophosphate catabolic processGO:000916940.051
response to biotic stimulusGO:0009607970.051
gtp metabolic processGO:004603940.051
regulation of cytokine productionGO:000181730.051
camera type eye developmentGO:00430102220.051
convergent extensionGO:00600261180.051
pigmentationGO:0043473850.050
growthGO:00400071740.050
positive regulation of cellular catabolic processGO:003133130.050
cellular response to external stimulusGO:007149620.049
brain developmentGO:00074202930.049
heterocycle metabolic processGO:00464832900.049
regulation of sequestering of calcium ionGO:005128240.049
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.048
regulation of signal transductionGO:00099662250.048
multicellular organism growthGO:003526440.046
positive regulation of catabolic processGO:000989640.046
angiogenesisGO:00015251580.046
cognitionGO:005089010.046
cell part morphogenesisGO:00329902460.045
lipid storageGO:001991510.045
positive regulation of canonical wnt signaling pathwayGO:009026340.045
positive regulation of protein complex assemblyGO:003133420.045
oxoacid metabolic processGO:0043436310.044
mitotic g2 dna damage checkpointGO:000709530.044
regulation of multicellular organism growthGO:004001440.044
response to other organismGO:0051707970.043
positive regulation of purine nucleotide catabolic processGO:003312310.043
segmentationGO:0035282970.043
hemopoiesisGO:00300971830.043
gland developmentGO:00487321430.042
cell projection assemblyGO:0030031640.042
negative regulation of nuclear divisionGO:005178430.042
negative regulation of protein kinase activityGO:000646940.042
tube morphogenesisGO:00352393490.042
negative regulation of signalingGO:0023057960.042
i kappab kinase nf kappab signalingGO:000724940.041
meiosis iGO:000712710.041
localization of cellGO:00516742440.041
blood vessel developmentGO:00015682460.040
eye developmentGO:00016542770.040
regulation of gtp catabolic processGO:003312420.040
single organism metabolic processGO:00447102170.040
Mouse Rat
nuclear importGO:005117030.040
positive regulation of jun kinase activityGO:004350720.040
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.039
cilium morphogenesisGO:0060271850.039
positive regulation of cellular component biogenesisGO:004408930.039
negative regulation of synapse assemblyGO:005196420.039
transcription from rna polymerase ii promoterGO:0006366800.039
defense response to other organismGO:0098542330.039
muscle cell differentiationGO:00426921390.039
positive regulation of gtp catabolic processGO:003312610.039
deathGO:00162651210.038
Mouse
regulation of bindingGO:005109830.038
small molecule metabolic processGO:0044281770.038
positive regulation of inflammatory responseGO:005072910.038
central nervous system developmentGO:00074173870.037
regulation of extrinsic apoptotic signaling pathwayGO:200123630.037
cellular protein metabolic processGO:00442671290.037
positive regulation of cytokine productionGO:000181920.036
purine nucleoside monophosphate catabolic processGO:000912840.036
regulation of biological qualityGO:00650082630.036
cilium organizationGO:0044782710.036
cellular response to molecule of bacterial originGO:007121930.036
head developmentGO:00603223030.035
viral processGO:001603210.035
autophagyGO:000691440.035
muscle structure developmentGO:00610611960.035
ribonucleoside monophosphate catabolic processGO:000915840.035
regulation of establishment of protein localizationGO:007020140.035
regulation of nucleoside metabolic processGO:000911820.035
regulation of meiotic cell cycleGO:005144510.034
sequestering of metal ionGO:005123830.034
cell surface receptor signaling pathwayGO:00071663250.034
protein import into nucleusGO:000660630.034
cellular component biogenesisGO:00440851780.034
negative regulation of mitosisGO:004583930.034
response to uvGO:000941130.034
g1 s transition of mitotic cell cycleGO:000008210.033
establishment of localization in cellGO:0051649770.033
regulation of response to stimulusGO:00485832690.033
mitotic cell cycle embryonicGO:004544820.033
apoptotic processGO:00069151160.033
Mouse
negative regulation of response to stimulusGO:00485851040.033
embryonic organ developmentGO:00485683810.033
organic acid metabolic processGO:0006082310.033
protein acylationGO:004354330.033
protein importGO:001703830.032
protein secretionGO:000930610.032
cellular amine metabolic processGO:004410620.032
cell projection morphogenesisGO:00488582440.032
symbiosis encompassing mutualism through parasitismGO:004440340.032
cellular response to nutrient levelsGO:003166920.032
phosphate containing compound metabolic processGO:00067961080.032
cellular response to dna damage stimulusGO:0006974240.032
Mouse Rat
negative regulation of sequestering of calcium ionGO:005128340.032
negative regulation of signal transductionGO:0009968940.032
cell cycle g1 s phase transitionGO:004484310.032
protein localization to plasma membraneGO:007265910.032
retina development in camera type eyeGO:00600411460.031
cellular response to chemical stimulusGO:00708871570.031
negative regulation of macromolecule metabolic processGO:0010605760.031
regulation of cellular component organizationGO:0051128860.031
regulation of circadian rhythmGO:004275240.031
regulation of cell differentiationGO:00455951420.031
neuron projection guidanceGO:0097485860.031
organonitrogen compound metabolic processGO:1901564740.031
blood vessel morphogenesisGO:00485142160.031
somitogenesisGO:0001756870.031
mitotic cytokinesisGO:000028130.031
negative regulation of secretionGO:005104820.031
single organism nuclear importGO:190259330.031
cellular response to organic substanceGO:00713101050.031
hematopoietic or lymphoid organ developmentGO:00485341910.031
nuclear divisionGO:0000280230.031
single organism organelle organizationGO:19025891990.030
cell cycleGO:0007049930.030
response to corticosteroidGO:003196010.030
protein acetylationGO:000647320.030
negative regulation of protein phosphorylationGO:000193340.030
negative regulation of cell communicationGO:0010648960.030
negative regulation of kinase activityGO:003367340.030
cellular component assemblyGO:00226071700.030
regulation of intracellular protein transportGO:003315730.030
negative regulation of macromolecule biosynthetic processGO:0010558480.030
cellular response to extracellular stimulusGO:003166820.030
transportGO:00068102200.030
cellular component assembly involved in morphogenesisGO:00109271070.029
negative regulation of cellular metabolic processGO:0031324770.029
phagocytosisGO:000690930.029
positive regulation of nucleotide catabolic processGO:003081310.029
response to organic substanceGO:00100331530.029
Rat
eye morphogenesisGO:00485921440.029
central nervous system neuron differentiationGO:0021953740.029
meiotic chromosome segregationGO:004513230.029
regulation of mrna splicing via spliceosomeGO:004802430.029
cellular response to biotic stimulusGO:007121630.028
heart processGO:0003015710.028
regulation of cell activationGO:005086510.028
organelle assemblyGO:00709251100.028
internal peptidyl lysine acetylationGO:001839320.028
phagocytosis engulfmentGO:000691110.028
neural retina developmentGO:0003407490.028
cellular response to starvationGO:000926710.028
positive regulation of jnk cascadeGO:004633030.028
somite developmentGO:0061053960.028
cell migration involved in gastrulationGO:0042074790.028
establishment of protein localization to organelleGO:007259440.028
carboxylic acid metabolic processGO:0019752220.028
olfactory bulb developmentGO:002177240.027
mitotic dna integrity checkpointGO:004477440.027
heart morphogenesisGO:00030071560.027
regulation of synaptic plasticityGO:004816710.027
regulation of cell deathGO:00109411030.027
peptidyl lysine acetylationGO:001839420.027
organelle localizationGO:0051640490.027
carbohydrate derivative metabolic processGO:1901135610.027
mitotic cell cycle processGO:1903047480.027
developmental programmed cell deathGO:001062340.027
cell morphogenesis involved in neuron differentiationGO:00486671630.027
internal protein amino acid acetylationGO:000647520.027
positive regulation of cell cycleGO:004578730.027
liver developmentGO:0001889960.026
axonogenesisGO:00074091520.026
regulation of cytoplasmic transportGO:190364940.026
response to bacteriumGO:0009617580.026
regulation of mrna processingGO:005068430.026
regulation of synapse organizationGO:005080730.026
macroautophagyGO:001623610.026
cellular response to stressGO:0033554620.026
Mouse Rat
ameboidal type cell migrationGO:00016671430.026
regulation of protein modification by small protein conjugation or removalGO:190332030.026
positive regulation of nucleoside metabolic processGO:004597910.026
anterior posterior pattern specificationGO:00099521520.026
nuclear transportGO:005116940.026
regulation of protein import into nucleusGO:004230620.026
protein metabolic processGO:00195381830.026
response to external biotic stimulusGO:0043207970.026
response to inorganic substanceGO:0010035380.025
taxisGO:00423301090.025
neuron remodelingGO:001632210.025
negative regulation of rna biosynthetic processGO:1902679450.025
convergent extension involved in gastrulationGO:0060027710.025
stem cell maintenanceGO:001982740.025
single organism transportGO:00447652060.025
cytosolic calcium ion transportGO:006040130.025
regulation of i kappab kinase nf kappab signalingGO:004312240.025
negative regulation of nitrogen compound metabolic processGO:0051172590.025
glial cell migrationGO:000834730.025
cellular amino acid metabolic processGO:000652070.025
hepaticobiliary system developmentGO:0061008980.025
immune system developmentGO:00025201910.024
regulation of gtpase activityGO:004308720.024
cilium assemblyGO:0042384580.024
cytoskeleton organizationGO:0007010960.024
neuron projection developmentGO:00311751800.024
programmed cell deathGO:00125011190.024
Mouse
embryonic organ morphogenesisGO:00485622740.023
stem cell proliferationGO:007208940.023
macromolecule methylationGO:0043414190.023
embryonic skeletal system developmentGO:0048706970.023
striated muscle cell developmentGO:00550021080.023
positive regulation of response to stimulusGO:0048584800.023
embryonic pattern specificationGO:0009880440.023
tissue remodelingGO:004877140.023
mitotic dna damage checkpointGO:004477340.023
regulation of catalytic activityGO:0050790550.023
negative regulation of cellular biosynthetic processGO:0031327550.023
positive regulation of gtpase activityGO:004354710.023
sequestering of calcium ionGO:005120830.023
multi organism processGO:00517041340.023
protein complex disassemblyGO:004324110.023
negative regulation of biosynthetic processGO:0009890550.023
nucleocytoplasmic transportGO:000691340.023
regulation of anatomical structure morphogenesisGO:00226031300.023
negative regulation of secretion by cellGO:190353120.023
regulation of cellular amine metabolic processGO:003323800.023
regulation of cell shapeGO:000836010.023
amine metabolic processGO:000930820.023
regulation of endopeptidase activityGO:0052548230.022
positive regulation of cytosolic calcium ion concentrationGO:000720440.022
regulation of signalingGO:00230512350.022
regulation of multicellular organismal developmentGO:20000262230.022
membrane fusionGO:006102520.022
mitotic g2 m transition checkpointGO:004481830.022
protein targeting to nucleusGO:004474430.022
negative chemotaxisGO:005091910.022
regulation of autophagyGO:001050630.022
regulation of cellular amino acid metabolic processGO:000652100.022
nucleotide metabolic processGO:0009117280.022
mitotic nuclear divisionGO:0007067180.022
atp catabolic processGO:000620040.022
response to ketoneGO:190165410.022
cellular component disassemblyGO:002241110.022
outflow tract morphogenesisGO:000315110.022
translational initiationGO:000641330.022
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.021
regulation of cell cycleGO:0051726520.021
dorsal ventral axis specificationGO:0009950140.021
regulation of programmed cell deathGO:00430671010.021
response to transition metal nanoparticleGO:1990267280.021
protein localization to nucleusGO:003450430.021
mitotic cell cycleGO:0000278640.021
response to oxygen containing compoundGO:1901700550.021
Rat
regulation of inflammatory responseGO:005072720.021
membrane invaginationGO:001032410.021
cell divisionGO:0051301200.021
chemotaxisGO:00069351040.021
regulation of cellular carbohydrate metabolic processGO:001067540.021
regulation of blood pressureGO:000821710.021
regulation of apoptotic processGO:0042981980.021
response to woundingGO:00096111160.021
regulation of protein targetingGO:190353320.020
cellular ketone metabolic processGO:0042180110.020
olfactory lobe developmentGO:002198840.020
rna modificationGO:000945120.020
positive regulation of signalingGO:0023056560.020
cellular localizationGO:0051641970.020
cell fate commitmentGO:0045165990.020
fin regenerationGO:0031101510.020
macromolecule modificationGO:00434121110.020
cytokinetic processGO:003250620.020
neuron projection morphogenesisGO:00488121610.020
positive regulation of epithelial cell proliferationGO:005067910.020
single organism biosynthetic processGO:0044711710.020
negative regulation of metabolic processGO:0009892860.020
negative regulation of defense responseGO:003134820.020
cell cycle processGO:0022402530.020
cell cycle arrestGO:000705010.019
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.019
specification of symmetryGO:00097992040.019
interspecies interaction between organismsGO:004441940.019
regulation of protein transportGO:005122330.019
regulation of wnt signaling pathwayGO:0030111530.019
positive regulation of i kappab kinase nf kappab signalingGO:004312330.019
b cell differentiationGO:003018310.019
regulation of cellular ketone metabolic processGO:001056570.019
fertilizationGO:000956630.019
spliceosomal complex assemblyGO:000024510.019
camera type eye morphogenesisGO:00485931080.019
regulation of protein ubiquitinationGO:003139630.019
response to amino acidGO:004320020.019
leukocyte differentiationGO:0002521250.019
negative regulation of protein transportGO:005122430.019
regenerationGO:0031099910.019
cell morphogenesis involved in differentiationGO:00009041950.019
circulatory system processGO:0003013870.018
negative regulation of protein kinase b signalingGO:005189820.018
forebrain developmentGO:0030900960.018
regulation of nucleocytoplasmic transportGO:004682220.018
chemosensory behaviorGO:000763510.018
organelle fissionGO:0048285230.018
negative regulation of cellular component organizationGO:0051129160.018
reciprocal dna recombinationGO:003582510.018
cell proliferationGO:0008283800.018
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.018
optic placode formation involved in camera type eye formationGO:004661930.018
regulation of protein localization to nucleusGO:190018020.018
axon guidanceGO:0007411860.018
muscle organ developmentGO:00075171010.018
response to ionizing radiationGO:001021260.018
Rat
response to glucocorticoidGO:005138410.018
zymogen activationGO:003163830.018
nucleoside monophosphate catabolic processGO:000912540.018
forebrain cell migrationGO:002188510.018
positive regulation of secretionGO:005104710.018
somatic stem cell maintenanceGO:003501910.017
organelle fusionGO:004828430.017
ribonucleoprotein complex biogenesisGO:0022613130.017
defense response to bacteriumGO:0042742220.017
morphogenesis of an epitheliumGO:00020093330.017
wnt signaling pathwayGO:0016055800.017
axon midline choice point recognitionGO:001619940.017
regulation of canonical wnt signaling pathwayGO:0060828340.017
cell projection organizationGO:00300302840.017
response to radiationGO:0009314510.017
Rat
positive regulation of peptidase activityGO:0010952100.017
negative regulation of nucleic acid templated transcriptionGO:1903507450.017
negative regulation of mapk cascadeGO:004340940.017
positive regulation of signal transductionGO:0009967560.017
positive regulation of developmental processGO:0051094500.017
sensory perception of painGO:001923310.017
inner ear developmentGO:00488391260.017
g2 dna damage checkpointGO:003157230.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
neuroblast proliferationGO:000740520.016
positive regulation of defense responseGO:003134990.016
negative regulation of transcription dna templatedGO:0045892450.016
rna 3 end processingGO:003112320.016
regulation of cellular protein catabolic processGO:190336210.016
muscle cell developmentGO:00550011150.016
negative regulation of multicellular organismal processGO:0051241690.016
peptide transportGO:001583310.016
positive regulation of nucleobase containing compound metabolic processGO:0045935690.016
response to drugGO:004249330.016
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.016
positive regulation of metabolic processGO:00098931080.016
myeloid cell differentiationGO:0030099860.016
adult behaviorGO:003053420.016
embryonic heart tube developmentGO:00350501330.016
skeletal muscle tissue developmentGO:0007519670.016
regulation of jun kinase activityGO:004350630.016
macromolecular complex disassemblyGO:003298410.016
embryonic limb morphogenesisGO:003032620.016
glucose homeostasisGO:004259310.016
positive regulation of cellular metabolic processGO:0031325940.016
protein complex localizationGO:003150310.016
regulation of defense responseGO:0031347140.016
response to temperature stimulusGO:0009266150.016
cellular protein modification processGO:00064641000.016
homeostatic processGO:00425921420.016
single organism membrane fusionGO:004480120.015
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.015
determination of bilateral symmetryGO:00098552040.015
metal ion transportGO:0030001580.015
developmental growth involved in morphogenesisGO:0060560860.015
regulation of cell growthGO:0001558290.015
microtubule cytoskeleton organization involved in mitosisGO:190285010.015
female meiotic divisionGO:000714320.015
axis specificationGO:0009798430.015
response to unfolded proteinGO:000698620.015
reflexGO:006000420.015
mesoderm developmentGO:0007498880.015
positive regulation of cell communicationGO:0010647560.015
single organism cellular localizationGO:1902580460.015
positive regulation of immune effector processGO:000269930.015
synaptic growth at neuromuscular junctionGO:005112420.015
heart contractionGO:0060047710.015
positive regulation of cell activationGO:005086710.015
extrinsic apoptotic signaling pathwayGO:009719130.015
cellular carbohydrate metabolic processGO:004426240.015
regulation of response to biotic stimulusGO:000283120.015
establishment of organelle localizationGO:0051656450.015
positive regulation of secretion by cellGO:190353210.015
macromolecule localizationGO:0033036540.015
ion transportGO:00068111140.015
b cell activationGO:004211320.015
stem cell differentiationGO:00488631170.015
neuron neuron synaptic transmissionGO:000727010.015
regulation of reproductive processGO:200024140.015
negative regulation of cytokine productionGO:000181810.015
acylglycerol homeostasisGO:005509020.015
cellular response to unfolded proteinGO:003462020.014

polb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.048
nervous system diseaseDOID:86300.033
musculoskeletal system diseaseDOID:1700.027
cardiovascular system diseaseDOID:128700.027
intrinsic cardiomyopathyDOID:006003600.027
cardiomyopathyDOID:005070000.027
heart diseaseDOID:11400.027
muscular diseaseDOID:008000000.027
myopathyDOID:42300.027
muscle tissue diseaseDOID:6600.027