Danio rerio

45 known processes

otx2

orthodenticle homolog 2

(Aliases: zOtx2,id:ibd2915,zotx-2,MGC136535,zgc:136535)

otx2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
aromatic compound biosynthetic processGO:00194382170.997
Human Zebrafish Mouse Worm Fly
brain developmentGO:00074202930.997
camera type eye morphogenesisGO:00485931080.997
generation of neuronsGO:00486993850.996
Human Zebrafish Mouse Worm Fly
neuron differentiationGO:00301823530.994
Human Zebrafish Mouse Worm Fly
eye photoreceptor cell differentiationGO:0001754450.990
Zebrafish Mouse Fly
sensory organ morphogenesisGO:00905962000.989
Zebrafish Mouse Fly
regulation of gene expressionGO:00104682650.986
Human Zebrafish Mouse Worm Fly
photoreceptor cell differentiationGO:0046530550.986
Zebrafish Mouse Fly
eye morphogenesisGO:00485921440.985
Zebrafish Mouse Fly
forebrain neuron fate commitmentGO:002187710.981
central nervous system developmentGO:00074173870.978
nucleic acid templated transcriptionGO:00976591810.973
Human Zebrafish Mouse Worm Fly
embryonic camera type eye developmentGO:0031076290.972
camera type eye developmentGO:00430102220.972
retina development in camera type eyeGO:00600411460.970
regulation of macromolecule biosynthetic processGO:00105562250.959
Human Zebrafish Mouse Worm Fly
cellular macromolecule biosynthetic processGO:00346452240.957
Human Zebrafish Mouse Worm Fly
cell morphogenesisGO:00009022890.952
Human Fly
diencephalon developmentGO:0021536580.947
Mouse
regulation of transcription dna templatedGO:00063552130.945
Human Zebrafish Mouse Worm Fly
regulation of macromolecule metabolic processGO:00602553170.934
Human Zebrafish Mouse Worm Fly
regulation of inner ear receptor cell differentiationGO:200098010.930
eye developmentGO:00016542770.927
chordate embryonic developmentGO:00430092710.925
transcription dna templatedGO:00063511810.917
Human Zebrafish Mouse Worm Fly
retina morphogenesis in camera type eyeGO:0060042790.916
retina layer formationGO:0010842240.915
forebrain neuron developmentGO:002188470.913
cell proliferation in forebrainGO:002184630.913
somitogenesisGO:0001756870.911
Mouse
head developmentGO:00603223030.908
photoreceptor cell developmentGO:0042461400.907
Zebrafish Fly
forebrain anterior posterior pattern specificationGO:002179730.907
compound eye developmentGO:004874920.905
Fly
cellular biosynthetic processGO:00442492860.903
Human Zebrafish Mouse Worm Fly
regionalizationGO:00030022740.900
brain morphogenesisGO:0048854180.899
Mouse
regulation of primary metabolic processGO:00800903110.897
Human Zebrafish Mouse Worm Fly
eye photoreceptor cell developmentGO:0042462300.894
Zebrafish Fly
forebrain dorsal ventral pattern formationGO:002179810.893
regulation of mechanoreceptor differentiationGO:004563110.886
cell fate commitmentGO:0045165990.871
Mouse Worm Fly
heterocycle biosynthetic processGO:00181302150.871
Human Zebrafish Mouse Worm Fly
neural tube developmentGO:0021915620.870
photoreceptor cell fate commitmentGO:004655210.858
Mouse Fly
nucleobase containing compound biosynthetic processGO:00346542050.851
Human Zebrafish Mouse Worm Fly
oligodendrocyte cell fate specificationGO:002177840.847
organic cyclic compound metabolic processGO:19013603010.845
Human Zebrafish Mouse Worm Fly
sensory organ developmentGO:00074233930.842
nucleobase containing compound metabolic processGO:00061392740.842
Human Zebrafish Mouse Worm Fly
neuron developmentGO:00486662620.837
Human Zebrafish Fly
thalamus developmentGO:002179460.829
forebrain regionalizationGO:002187140.828
regulation of biosynthetic processGO:00098892500.824
Human Zebrafish Mouse Worm Fly
rostrocaudal neural tube patterningGO:0021903290.806
neuron projection morphogenesisGO:00488121610.802
Human Fly
embryonic camera type eye morphogenesisGO:0048596190.799
ameboidal type cell migrationGO:00016671430.795
cell surface receptor signaling pathwayGO:00071663250.793
cellular aromatic compound metabolic processGO:00067252950.789
Human Zebrafish Mouse Worm Fly
vasculogenesisGO:0001570410.777
neuron fate commitmentGO:0048663260.776
Mouse Worm Fly
neural crest cell migrationGO:0001755420.771
pancreatic a cell developmentGO:000332220.767
forebrain generation of neuronsGO:0021872140.762
regulation of cellular metabolic processGO:00313233200.753
Human Zebrafish Mouse Worm Fly
neuron fate specificationGO:0048665200.751
Worm
regulation of nucleic acid templated transcriptionGO:19035062130.749
Human Zebrafish Mouse Worm Fly
nucleic acid metabolic processGO:00903042440.745
Human Zebrafish Mouse Worm Fly
neural tube patterningGO:0021532330.744
central nervous system neuron differentiationGO:0021953740.736
positive regulation of cellular processGO:00485222010.733
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic processGO:19013622230.728
Human Zebrafish Mouse Worm Fly
pancreatic d cell differentiationGO:000331120.724
hindbrain developmentGO:0030902910.719
neural retina developmentGO:0003407490.718
embryo development ending in birth or egg hatchingGO:00097922710.706
retinal pigment epithelium developmentGO:000340680.703
regulation of rna biosynthetic processGO:20011412130.689
Human Zebrafish Mouse Worm Fly
forebrain midbrain boundary formationGO:002190510.688
cellular macromolecule metabolic processGO:00442603910.685
Human Zebrafish Mouse Worm Fly
embryonic organ developmentGO:00485683810.676
Mouse
ventral spinal cord developmentGO:0021517350.667
blood vessel morphogenesisGO:00485142160.664
regulation of transcription from rna polymerase iii promoterGO:000635910.650
gastrulationGO:00073692080.644
Mouse
regulation of metabolic processGO:00192223590.642
Human Zebrafish Mouse Worm Fly
abducens nucleus developmentGO:002174220.627
positive regulation of nucleobase containing compound metabolic processGO:0045935690.625
Human Zebrafish Mouse Worm Fly
columnar cuboidal epithelial cell differentiationGO:0002065380.623
signal transductionGO:00071654550.616
stem cell proliferationGO:007208940.612
positive regulation of neuron migrationGO:200122420.596
camera type eye photoreceptor cell differentiationGO:0060219190.593
mesenchymal cell differentiationGO:0048762870.593
central nervous system myelin formationGO:003228910.574
anterior posterior pattern specificationGO:00099521520.573
rna biosynthetic processGO:00327741810.572
Human Zebrafish Mouse Worm Fly
midbrain hindbrain boundary developmentGO:0030917230.565
negative regulation of translational initiationGO:004594710.564
regulation of rna metabolic processGO:00512522240.562
Human Zebrafish Mouse Worm Fly
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.554
Fly
embryonic heart tube developmentGO:00350501330.548
cellular nitrogen compound metabolic processGO:00346412900.545
Human Zebrafish Mouse Worm Fly
heterocycle metabolic processGO:00464832900.543
Human Zebrafish Mouse Worm Fly
cell differentiation in spinal cordGO:0021515400.537
neural crest cell developmentGO:0014032620.536
regulation of nucleobase containing compound metabolic processGO:00192192500.529
Human Zebrafish Mouse Worm Fly
retinal cell programmed cell deathGO:004666620.521
Zebrafish
nitrogen compound metabolic processGO:00068073190.520
Human Zebrafish Mouse Worm Fly
embryonic retina morphogenesis in camera type eyeGO:0060059220.515
organic substance biosynthetic processGO:19015762890.511
Human Zebrafish Mouse Worm Fly
epithelial cell differentiationGO:00308551160.509
glial cell developmentGO:0021782200.507
epidermal cell fate specificationGO:000995740.503
regulation of nervous system developmentGO:0051960900.500
Fly
positive regulation of stem cell proliferationGO:200064810.499
gliogenesisGO:0042063450.491
regulation of transcription from rna polymerase ii promoterGO:00063571140.486
Human Mouse Worm Fly
morphogenesis of an epitheliumGO:00020093330.485
spinal cord developmentGO:0021510460.485
positive regulation of rna metabolic processGO:0051254590.482
Human Zebrafish Mouse Worm Fly
regulation of cellular biosynthetic processGO:00313262450.478
Human Zebrafish Mouse Worm Fly
regulation of cell differentiationGO:00455951420.455
Zebrafish Fly
neuron projection developmentGO:00311751800.450
Human Fly
forebrain developmentGO:0030900960.437
Mouse
embryonic eye morphogenesisGO:0048048300.433
biosynthetic processGO:00090582940.432
Human Zebrafish Mouse Worm Fly
regulation of stem cell proliferationGO:007209120.426
forebrain neuron differentiationGO:0021879140.418
negative regulation of nucleobase containing compound metabolic processGO:0045934590.418
Fly
mesenchymal cell developmentGO:0014031780.413
ear developmentGO:00435831270.408
Mouse
rna metabolic processGO:00160702190.408
Human Zebrafish Mouse Worm Fly
regulation of neural precursor cell proliferationGO:200017730.407
regulation of transcription involved in cell fate commitmentGO:006085010.404
regulation of signalingGO:00230512350.403
cell projection morphogenesisGO:00488582440.401
Human Fly
limb bud formationGO:006017420.398
glial cell fate commitmentGO:002178160.394
glial cell fate specificationGO:002178040.388
positive regulation of rna biosynthetic processGO:1902680570.385
Human Zebrafish Mouse Worm Fly
negative regulation of cellular processGO:00485232830.377
Zebrafish Fly
spinal cord motor neuron differentiationGO:0021522260.368
auditory receptor cell fate commitmentGO:000991240.363
regulation of cellular macromolecule biosynthetic processGO:20001122220.353
Human Zebrafish Mouse Worm Fly
positive regulation of neural precursor cell proliferationGO:200017910.349
system processGO:00030081850.349
Zebrafish Worm
response to light stimulusGO:0009416460.345
neural crest cell differentiationGO:0014033720.341
cellular component morphogenesisGO:00329893360.339
Human Fly
hindbrain morphogenesisGO:0021575220.339
regulation of nitrogen compound metabolic processGO:00511712510.333
Human Zebrafish Mouse Worm Fly
cellular component movementGO:00069283350.332
Human
glial cell differentiationGO:0010001420.331
negative regulation of nervous system developmentGO:0051961220.331
peripheral nervous system neuron differentiationGO:0048934280.331
morphogenesis of embryonic epitheliumGO:0016331300.325
blood vessel developmentGO:00015682460.323
regulation of neurogenesisGO:0050767870.323
Fly
neuroblast proliferationGO:000740520.319
cellular response to prostaglandin stimulusGO:007137930.310
inner ear receptor cell fate commitmentGO:006012040.307
epidermis developmentGO:0008544480.306
segmentationGO:0035282970.299
Mouse Fly
iris morphogenesisGO:006107210.297
lens morphogenesis in camera type eyeGO:000208970.297
cellular nitrogen compound biosynthetic processGO:00442712180.296
Human Zebrafish Mouse Worm Fly
gene expressionGO:00104672520.295
Human Zebrafish Mouse Worm Fly
melanocyte differentiationGO:0030318260.293
positive regulation of cell fate specificationGO:004266010.284
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.283
positive regulation of nitrogen compound metabolic processGO:0051173690.281
Human Zebrafish Mouse Worm Fly
pigment granule organizationGO:004875340.277
mammillary body developmentGO:002176740.275
cranial ganglion developmentGO:006155030.274
negative regulation of nitrogen compound metabolic processGO:0051172590.272
Fly
negative regulation of cellular biosynthetic processGO:0031327550.271
Fly
neuroblast fate determinationGO:000740010.268
positive regulation of gene expressionGO:0010628710.265
Human Zebrafish Mouse Worm Fly
somite developmentGO:0061053960.257
Mouse
positive regulation of cellular biosynthetic processGO:0031328680.253
Human Zebrafish Mouse Worm Fly
negative regulation of gene expressionGO:0010629650.249
Fly
vasculature developmentGO:00019442780.247
convergent extensionGO:00600261180.247
digestive tract developmentGO:00485652650.246
Mouse
stem cell differentiationGO:00488631170.245
pancreas developmentGO:0031016840.243
macromolecule biosynthetic processGO:00090592270.243
Human Zebrafish Mouse Worm Fly
epidermal cell differentiationGO:0009913360.241
axon ensheathmentGO:0008366180.240
heart developmentGO:00075073130.238
photoreceptor cell fate specificationGO:004370410.236
digestive system developmentGO:00551232890.235
Mouse
mesoderm developmentGO:0007498880.234
regulation of neuron migrationGO:200122220.233
cell morphogenesis involved in differentiationGO:00009041950.231
Human Fly
negative regulation of rna metabolic processGO:0051253480.231
Fly
heart loopingGO:0001947940.230
enzyme linked receptor protein signaling pathwayGO:00071671060.230
morphogenesis of an epithelial sheetGO:0002011490.221
central nervous system myelinationGO:002201020.209
retinal cone cell developmentGO:004654980.207
mechanoreceptor differentiationGO:0042490370.206
atrioventricular valve formationGO:000319030.202
negative regulation of retinal cell programmed cell deathGO:004667120.201
Zebrafish
negative regulation of cell developmentGO:0010721260.201
Zebrafish
somite specificationGO:0001757120.200
determination of bilateral symmetryGO:00098552040.200
anterior commissure morphogenesisGO:002196030.195
ectodermal placode developmentGO:0071696370.195
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.194
Fly
regulation of epithelial cell proliferationGO:005067830.193
regulation of multicellular organismal processGO:00512392770.192
Zebrafish Mouse Fly
aorta developmentGO:003590440.192
embryonic epithelial tube formationGO:0001838170.191
negative regulation of neurogenesisGO:0050768200.190
negative regulation of macromolecule biosynthetic processGO:0010558480.189
Fly
optic cup morphogenesis involved in camera type eye developmentGO:000207270.188
pituitary gland developmentGO:0021983160.187
neural tube formationGO:0001841160.187
positive regulation of transcription dna templatedGO:0045893570.183
Human Zebrafish Mouse Worm Fly
positive regulation of cell fate commitmentGO:001045510.176
dorsal ventral pattern formationGO:00099531250.176
Mouse
neuron projection guidanceGO:0097485860.175
Human
cardiac cell fate commitmentGO:006091110.175
neuroblast differentiationGO:001401610.175
cell cycleGO:0007049930.172
regulation of multicellular organismal developmentGO:20000262230.172
Zebrafish Mouse Fly
glial cell migrationGO:000834730.172
inner ear developmentGO:00488391260.171
Mouse
ventral spinal cord interneuron fate commitmentGO:006057930.170
retinal cone cell differentiationGO:0042670120.168
determination of left right symmetryGO:00073681790.161
positive regulation of macromolecule metabolic processGO:0010604930.160
Human Zebrafish Mouse Worm Fly
cilium organizationGO:0044782710.159
cellular component assembly involved in morphogenesisGO:00109271070.157
muscle structure developmentGO:00610611960.157
skin developmentGO:0043588540.155
inner ear receptor cell differentiationGO:0060113290.154
digestive tract morphogenesisGO:00485462310.154
Mouse
embryonic pattern specificationGO:0009880440.152
Mouse
angiogenesisGO:00015251580.148
cell morphogenesis involved in neuron differentiationGO:00486671630.144
Human Fly
central nervous system neuron developmentGO:0021954290.143
developmental growth involved in morphogenesisGO:0060560860.143
lens development in camera type eyeGO:0002088220.141
primary neural tube formationGO:001402010.138
inner ear morphogenesisGO:0042472630.138
Mouse
positive regulation of nervous system developmentGO:0051962250.137
Fly
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.136
Human Mouse Worm Fly
neuron fate determinationGO:004866420.135
Mouse
regulation of cell developmentGO:00602841000.134
Zebrafish Fly
multi organism processGO:00517041340.133
sympathetic nervous system developmentGO:004848530.132
auditory receptor cell differentiationGO:0042491150.132
cellular response to fatty acidGO:007139830.130
neural crest formationGO:0014029140.129
pharyngeal muscle developmentGO:004328240.128
neuromast mantle cell differentiationGO:004888810.127
embryonic heart tube morphogenesisGO:00031431080.126
response to chemicalGO:00422213200.126
cell fate commitment involved in pattern specificationGO:006058160.125
neuroepithelial cell differentiationGO:0060563260.125
specification of symmetryGO:00097992040.125
axon guidanceGO:0007411860.124
Human
maintenance of locationGO:005123540.124
determination of pancreatic left right asymmetryGO:0035469110.124
axon ensheathment in central nervous systemGO:003229120.124
lateral line ganglion developmentGO:004889020.123
olfactory lobe developmentGO:002198840.123
neuroblast fate commitmentGO:001401710.122
larval developmentGO:000216420.120
glial cell fate determinationGO:000740310.119
artery developmentGO:0060840220.119
cell part morphogenesisGO:00329902460.118
Human Fly
formation of primary germ layerGO:0001704620.117
positive regulation of biological processGO:00485182530.115
Human Zebrafish Mouse Worm Fly
stem cell fate determinationGO:004886710.114
mesenchyme developmentGO:00604851270.112
cell migrationGO:00164772370.112
extraocular skeletal muscle developmentGO:000207430.109
spinal cord oligodendrocyte cell fate specificationGO:002153020.106
epithelial tube formationGO:0072175190.106
single organism organelle organizationGO:19025891990.105
ectodermal placode formationGO:0060788260.105
negative regulation of biosynthetic processGO:0009890550.105
Fly
myeloid cell differentiationGO:0030099860.104
localization of cellGO:00516742440.104
organelle organizationGO:00069962270.103
Fly
negative regulation of transcription dna templatedGO:0045892450.103
Fly
peripheral nervous system neuron developmentGO:0048935220.103
olfactory bulb developmentGO:002177240.102
endocrine pancreas developmentGO:0031018270.100
positive regulation of macromolecule biosynthetic processGO:0010557590.098
Human Zebrafish Mouse Worm Fly
ectodermal placode morphogenesisGO:0071697320.097
sensory epithelium regenerationGO:0070654140.097
axonogenesisGO:00074091520.096
Human
positive regulation of transportGO:005105020.094
gland developmentGO:00487321430.093
muscle tissue developmentGO:00605371100.090
pigment cell differentiationGO:0050931380.089
response to alcoholGO:0097305140.089
negative regulation of biological processGO:00485193040.088
Zebrafish Fly
regulation of developmental processGO:00507932470.088
Zebrafish Mouse Fly
hematopoietic or lymphoid organ developmentGO:00485341910.088
artery morphogenesisGO:0048844140.087
multicellular organismal water homeostasisGO:005089110.086
negative regulation of cell differentiationGO:0045596460.085
Zebrafish
nucleocytoplasmic transportGO:000691340.085
autonomic nervous system developmentGO:0048483190.084
response to axon injuryGO:0048678140.084
epithelial cell fate commitmentGO:0072148110.084
pancreatic d cell developmentGO:000332410.084
enteroendocrine cell differentiationGO:003588390.083
cell motilityGO:00488702440.082
heart formationGO:0060914130.082
cell proliferation in hindbrainGO:002153440.081
negative regulation of neuron differentiationGO:0045665100.080
segment specificationGO:0007379120.077
lipid storageGO:001991510.077
gabaergic neuron differentiationGO:009715420.077
regulation of response to stimulusGO:00485832690.077
water homeostasisGO:003010440.076
transcription from rna polymerase ii promoterGO:0006366800.075
Human Mouse Worm Fly
pronephric glomerulus developmentGO:0039021130.075
transmission of nerve impulseGO:0019226190.075
response to external stimulusGO:00096052640.075
Human
cerebellar cortex developmentGO:002169550.075
negative regulation of macromolecule metabolic processGO:0010605760.075
Fly
pronephros developmentGO:0048793690.075
positive regulation of metabolic processGO:00098931080.075
Human Zebrafish Mouse Worm Fly
endoderm developmentGO:0007492490.074
Mouse
stem cell fate commitmentGO:004886510.073
positive regulation of axon guidanceGO:190266910.073
stem cell developmentGO:0048864820.073
nuclear transportGO:005116940.073
axon extension involved in axon guidanceGO:0048846100.073
atrial ventricular junction remodelingGO:000329420.072
positive regulation of cellular metabolic processGO:0031325940.072
Human Zebrafish Mouse Worm Fly
fourth ventricle developmentGO:002159280.071
cellular pigmentationGO:0033059300.071
limbic system developmentGO:0021761160.071
notch signaling pathwayGO:0007219350.070
dopaminergic neuron differentiationGO:0071542140.070
determination of heart left right asymmetryGO:00613711170.070
posterior lateral line neuromast mantle cell differentiationGO:004892410.069
adenohypophysis developmentGO:0021984150.068
facial nucleus developmentGO:002175470.067
agingGO:000756820.067
hemopoiesisGO:00300971830.067
somatic motor neuron differentiationGO:002152350.066
aorta morphogenesisGO:003590930.066
chemosensory behaviorGO:000763510.065
Worm
forebrain cell migrationGO:002188510.065
nerve developmentGO:0021675450.064
negative regulation of wnt signaling pathwayGO:0030178300.063
auditory receptor cell developmentGO:006011780.063
negative regulation of rna biosynthetic processGO:1902679450.063
Fly
negative regulation of cellular metabolic processGO:0031324770.063
Fly
axis specificationGO:0009798430.062
Mouse
mesoderm morphogenesisGO:0048332510.062
closure of optic fissureGO:006138660.062
retinal ganglion cell axon guidanceGO:0031290350.062
embryonic camera type eye formationGO:0060900100.062
hair cell differentiationGO:0035315320.061
post embryonic morphogenesisGO:000988640.060
determination of left right asymmetry in lateral mesodermGO:0003140200.060
enteric nervous system developmentGO:0048484120.060
regulation of canonical wnt signaling pathwayGO:0060828340.060
peripheral nervous system neuron axonogenesisGO:0048936130.059
neuron neuron synaptic transmissionGO:000727010.059
negative regulation of epithelial cell proliferationGO:005068010.058
lymphatic endothelial cell differentiationGO:006083610.058
pigmentationGO:0043473850.058
negative regulation of gliogenesisGO:001401410.057
auditory receptor cell fate determinationGO:004266820.057
cell cell signalingGO:0007267520.057
oligodendrocyte developmentGO:001400370.057
myelinationGO:0042552180.057
formation of anatomical boundaryGO:0048859140.056
homeostatic processGO:00425921420.056
peripheral nervous system developmentGO:0007422550.056
muscle fiber developmentGO:0048747520.055
embryonic organ morphogenesisGO:00485622740.055
Mouse
oligodendrocyte cell fate commitmentGO:002177950.054
visual perceptionGO:0007601170.054
Zebrafish
protein targeting to nucleusGO:004474430.054
otic placode formationGO:0043049230.053
positive regulation of neurogenesisGO:0050769240.053
Fly
chemotaxisGO:00069351040.053
Human
endodermal cell fate determinationGO:000749320.052
canonical wnt signaling pathwayGO:0060070480.052
rho protein signal transductionGO:000726650.051
mesodermal to mesenchymal transition involved in gastrulationGO:006080910.051
neural precursor cell proliferationGO:0061351200.051
heart processGO:0003015710.051
cell migration involved in gastrulationGO:0042074790.050
pharyngeal system developmentGO:0060037180.050
negative regulation of nucleic acid templated transcriptionGO:1903507450.050
Fly
epithelial cell developmentGO:0002064420.049
establishment of localizationGO:00512342440.049
regulation of bindingGO:005109830.048
myeloid cell homeostasisGO:0002262560.048
negative regulation of leukocyte differentiationGO:190210610.048
regulation of biological qualityGO:00650082630.048
striated muscle tissue developmentGO:00147061100.048
glandular epithelial cell differentiationGO:000206790.048
spinal cord motor neuron cell fate specificationGO:002152080.047
proepicardium developmentGO:000334240.047
pericardium morphogenesisGO:000334410.047
retinal rod cell developmentGO:004654840.046
immune system processGO:00023762410.045
regulation of cell motilityGO:2000145460.045
cell proliferation in midbrainGO:003327840.045
negative regulation of protein phosphorylationGO:000193340.045
otic vesicle developmentGO:0071599420.044
positive regulation of endothelial cell differentiationGO:004560320.044
organ formationGO:0048645170.044
cardiac muscle tissue developmentGO:0048738480.044
anterior posterior axis specificationGO:0009948200.044
Mouse
ensheathment of neuronsGO:0007272180.043
regulation of neuron differentiationGO:0045664560.043
Fly
cell proliferation involved in heart morphogenesisGO:006132320.042
regulation of molecular functionGO:0065009700.042
developmental maturationGO:0021700340.042
optomotor responseGO:007163210.041
guanosine containing compound catabolic processGO:190106920.041
positive regulation of biosynthetic processGO:0009891680.041
Human Zebrafish Mouse Worm Fly
cell differentiation in hindbrainGO:002153350.041
mesoderm formationGO:0001707430.041
dorsal ventral axis specificationGO:0009950140.040
protein modification processGO:00362111000.040
endocardium formationGO:006021410.040
wnt signaling pathwayGO:0016055800.039
extracellular fibril organizationGO:004320610.039
immune system developmentGO:00025201910.039
heart valve formationGO:000318840.038
regulation of axon extensionGO:0030516240.038
positive regulation of cell developmentGO:0010720250.038
Fly
cell projection assemblyGO:0030031640.038
protein import into nucleusGO:000660630.038
gastrulation with mouth forming secondGO:0001702440.038
Mouse
endothelial cell fate commitmentGO:006083930.038
sensory perception of light stimulusGO:0050953190.037
Zebrafish
regulation of nucleoside metabolic processGO:000911820.037
cardiocyte differentiationGO:0035051440.037
intracellular estrogen receptor signaling pathwayGO:003052030.037
lymphatic endothelial cell fate commitmentGO:006083810.037
programmed cell deathGO:00125011190.037
Zebrafish
bmp signaling pathwayGO:0030509520.036
gtp metabolic processGO:004603940.036
cellular protein metabolic processGO:00442671290.036
epithelium regenerationGO:1990399140.036
tube closureGO:006060610.036
pectoral fin morphogenesisGO:0035138290.035
phosphorus metabolic processGO:00067931090.035
cilium assemblyGO:0042384580.035
single organism nuclear importGO:190259330.035
ear morphogenesisGO:0042471640.035
Mouse
circadian regulation of gene expressionGO:003292280.035
Zebrafish
negative regulation of signalingGO:0023057960.034
gtp catabolic processGO:000618420.034
somatic stem cell maintenanceGO:003501910.034
guanosine containing compound metabolic processGO:190106840.034
positive regulation of axon extension involved in axon guidanceGO:004884210.034
type b pancreatic cell differentiationGO:000330980.034
positive regulation of purine nucleotide catabolic processGO:003312310.034
cilium morphogenesisGO:0060271850.033
cell fate specificationGO:0001708680.033
Mouse Worm
eye field cell fate commitment involved in camera type eye formationGO:006089830.033
heart contractionGO:0060047710.033
regulation of intracellular protein transportGO:003315730.032
detection of abiotic stimulusGO:0009582240.032
regulation of signal transductionGO:00099662250.032
intermediate mesoderm developmentGO:004838920.032
dorsal aorta morphogenesisGO:003591230.032
multicellular organismal signalingGO:0035637220.031
stem cell divisionGO:001714510.031
peptide transportGO:001583310.031
dorsal aorta developmentGO:003590740.031
regulation of cell proliferation involved in heart morphogenesisGO:200013620.031
positive regulation of notch signaling pathwayGO:004574730.030
endochondral bone morphogenesisGO:006035080.030
astrocyte differentiationGO:004870810.030
oligodendrocyte differentiationGO:0048709230.029
circulatory system processGO:0003013870.029
spinal cord radial glial cell differentiationGO:002153120.029
cell projection organizationGO:00300302840.029
Human Fly

otx2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.678
Human
eye and adnexa diseaseDOID:149200.678
Human
disease of anatomical entityDOID:700.678
Human
sensory system diseaseDOID:005015500.678
Human
eye diseaseDOID:561400.154
Human
retinal diseaseDOID:567900.063
retinal degenerationDOID:846600.063
congenital nervous system abnormalityDOID:249000.035
physical disorderDOID:008001500.035