IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

atp1a1a.5

ATPase, Na+/K+ transporting, alpha 1a.5 polypeptide

(Aliases: cb709)

Ensembl: ENSDARG00000040252
Entrez: 245703
ZFIN: ZDB-GENE-020501-1
UniProtKB: Q8JIV1

Process Predictions
Disease Predictions

atp1a1a.5 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
sensory organ morphogenesis	GO:0090596	200	0.569	Zebrafish
ear development	GO:0043583	127	0.345	Zebrafish
positive regulation of biological process	GO:0048518	253	0.287	Mouse
vasculature development	GO:0001944	278	0.274
larval development	GO:0002164	2	0.273	Worm
single organism transport	GO:0044765	206	0.252	Human Zebrafish Mouse Rat Worm Fly
angiogenesis	GO:0001525	158	0.242
cellular component movement	GO:0006928	335	0.239	Zebrafish Rat
establishment of localization	GO:0051234	244	0.198	Human Zebrafish Mouse Rat Worm Fly
single organism localization	GO:1902578	225	0.172	Human Zebrafish Mouse Rat Worm Fly
single organism metabolic process	GO:0044710	217	0.156	Human Zebrafish Mouse Rat Worm Fly
small molecule metabolic process	GO:0044281	77	0.156	Human Zebrafish Mouse Rat Worm Fly
transmembrane transport	GO:0055085	120	0.156	Human Zebrafish Mouse Rat Worm Fly
central nervous system development	GO:0007417	387	0.153	Zebrafish
transport	GO:0006810	220	0.147	Human Zebrafish Mouse Rat Worm Fly
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.143	Human Zebrafish Mouse Rat Worm Fly
inner ear development	GO:0048839	126	0.140	Zebrafish
regulation of metabolic process	GO:0019222	359	0.133	Mouse
response to metal ion	GO:0010038	34	0.133
membrane repolarization	GO:0086009	2	0.125	Human
blood vessel morphogenesis	GO:0048514	216	0.125
membrane hyperpolarization	GO:0060081	1	0.123	Rat
tube morphogenesis	GO:0035239	349	0.119	Zebrafish
blood vessel development	GO:0001568	246	0.117
cellular sodium ion homeostasis	GO:0006883	1	0.117	Human
regulation of biological quality	GO:0065008	263	0.112	Human Zebrafish Mouse Rat Worm Fly
localization of cell	GO:0051674	244	0.111	Zebrafish
negative regulation of cellular process	GO:0048523	283	0.110	Mouse
regulation of cell shape	GO:0008360	1	0.109	Fly
sensory organ development	GO:0007423	393	0.109	Zebrafish
biosynthetic process	GO:0009058	294	0.109	Mouse
positive regulation of transport	GO:0051050	2	0.108
digestive tract development	GO:0048565	265	0.107
response to cadmium ion	GO:0046686	14	0.107
digestive tract morphogenesis	GO:0048546	231	0.106
macromolecule biosynthetic process	GO:0009059	227	0.104
ion transport	GO:0006811	114	0.104	Human Zebrafish Mouse Rat Worm Fly
generation of neurons	GO:0048699	385	0.103
cellular monovalent inorganic cation homeostasis	GO:0030004	2	0.102	Human
response to drug	GO:0042493	3	0.102	Mouse
embryonic organ development	GO:0048568	381	0.099	Zebrafish
semicircular canal development	GO:0060872	24	0.099	Zebrafish
neural tube patterning	GO:0021532	33	0.099	Zebrafish
inner ear morphogenesis	GO:0042472	63	0.098	Zebrafish
glucocorticoid metabolic process	GO:0008211	2	0.098	Mouse
hormone biosynthetic process	GO:0042446	3	0.098	Mouse
response to chemical	GO:0042221	320	0.096	Human Mouse
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.094	Human Zebrafish Mouse Rat Worm Fly
regulation of anatomical structure morphogenesis	GO:0022603	130	0.094	Fly
neural tube development	GO:0021915	62	0.092	Zebrafish
response to organic cyclic compound	GO:0014070	51	0.092	Human
locomotion	GO:0040011	313	0.090	Zebrafish
cellular biosynthetic process	GO:0044249	286	0.089	Mouse
nucleobase containing compound metabolic process	GO:0006139	274	0.087	Human Zebrafish Mouse Rat Worm Fly
negative regulation of biological process	GO:0048519	304	0.086	Mouse
nitrogen compound metabolic process	GO:0006807	319	0.084	Human Zebrafish Mouse Rat Worm Fly
response to endogenous stimulus	GO:0009719	83	0.084	Human
aging	GO:0007568	2	0.079	Fly
organonitrogen compound metabolic process	GO:1901564	74	0.078	Human Zebrafish Mouse Rat Worm Fly
cellular amine metabolic process	GO:0044106	2	0.077
maintenance of location	GO:0051235	4	0.076
response to transition metal nanoparticle	GO:1990267	28	0.076
posterior lateral line development	GO:0048916	38	0.076
ion transmembrane transport	GO:0034220	91	0.076	Human Zebrafish Mouse Rat Worm Fly
response to external stimulus	GO:0009605	264	0.075	Zebrafish Rat Fly
regulation of metal ion transport	GO:0010959	4	0.075	Rat
synaptic growth at neuromuscular junction	GO:0051124	2	0.074	Fly
determination of bilateral symmetry	GO:0009855	204	0.073	Zebrafish
actin mediated cell contraction	GO:0070252	1	0.072	Rat
regulation of cellular biosynthetic process	GO:0031326	245	0.071	Mouse
cellular aromatic compound metabolic process	GO:0006725	295	0.071	Human Zebrafish Mouse Rat Worm Fly
cellular nitrogen compound metabolic process	GO:0034641	290	0.071	Human Zebrafish Mouse Rat Worm Fly
regulation of multicellular organismal development	GO:2000026	223	0.069
cellular response to chemical stimulus	GO:0070887	157	0.068	Human
response to organic substance	GO:0010033	153	0.068	Human
homeostatic process	GO:0042592	142	0.067	Human Zebrafish Fly
signal transduction	GO:0007165	455	0.067
regulation of cytokine production	GO:0001817	3	0.067
eye development	GO:0001654	277	0.067
nucleoside monophosphate catabolic process	GO:0009125	4	0.066	Human Zebrafish Mouse Rat Worm Fly
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.066	Human Zebrafish Mouse Rat Worm Fly
cellular response to external stimulus	GO:0071496	2	0.064	Rat
actin filament based movement	GO:0030048	1	0.064	Rat
embryonic organ morphogenesis	GO:0048562	274	0.063	Zebrafish
protein localization to nucleus	GO:0034504	3	0.063
brain development	GO:0007420	293	0.062	Zebrafish
cell substrate adhesion	GO:0031589	4	0.062
embryo development ending in birth or egg hatching	GO:0009792	271	0.062	Zebrafish Worm Fly
sprouting angiogenesis	GO:0002040	53	0.060
ion homeostasis	GO:0050801	41	0.060	Human Zebrafish
regulation of multicellular organism growth	GO:0040014	4	0.059
heterocycle biosynthetic process	GO:0018130	215	0.059
system process	GO:0003008	185	0.059	Zebrafish Mouse Rat Worm Fly
organic cyclic compound biosynthetic process	GO:1901362	223	0.058	Mouse
cell motility	GO:0048870	244	0.057	Zebrafish
regulation of protein transport	GO:0051223	3	0.057
response to monosaccharide	GO:0034284	3	0.057
regulation of intracellular protein transport	GO:0033157	3	0.057
regulation of cellular metabolic process	GO:0031323	320	0.056	Mouse
otolith development	GO:0048840	32	0.055	Zebrafish
positive regulation of cellular component biogenesis	GO:0044089	3	0.055
amine metabolic process	GO:0009308	2	0.055
organic substance biosynthetic process	GO:1901576	289	0.055	Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.055
otic vesicle development	GO:0071599	42	0.055	Zebrafish
posterior lateral line system development	GO:0048915	46	0.054
positive regulation of catabolic process	GO:0009896	4	0.054
aromatic compound biosynthetic process	GO:0019438	217	0.054
heterocycle metabolic process	GO:0046483	290	0.053	Human Zebrafish Mouse Rat Worm Fly
regulation of localization	GO:0032879	104	0.053	Rat
metal ion transport	GO:0030001	58	0.052	Human Zebrafish Mouse Rat Worm Fly
cell migration	GO:0016477	237	0.052	Zebrafish
regulation of nitrogen compound metabolic process	GO:0051171	251	0.052
sensory system development	GO:0048880	76	0.051
response to steroid hormone	GO:0048545	35	0.051	Human
single organism biosynthetic process	GO:0044711	71	0.051	Mouse
hormone transport	GO:0009914	2	0.050
positive regulation of secretion by cell	GO:1903532	1	0.049
fluid transport	GO:0042044	17	0.049	Zebrafish
determination of left right symmetry	GO:0007368	179	0.049	Zebrafish
cellular ketone metabolic process	GO:0042180	11	0.049
regulation of sodium ion transport	GO:0002028	2	0.049	Rat
response to lipid	GO:0033993	60	0.049	Human
negative regulation of multicellular organismal process	GO:0051241	69	0.048	Mouse
response to xenobiotic stimulus	GO:0009410	45	0.048
extrinsic apoptotic signaling pathway	GO:0097191	3	0.048
organic acid metabolic process	GO:0006082	31	0.047
positive regulation of secretion	GO:0051047	1	0.046
taxis	GO:0042330	109	0.046	Zebrafish
heart development	GO:0007507	313	0.046	Zebrafish
regulation of establishment of protein localization	GO:0070201	4	0.045
peripheral nervous system development	GO:0007422	55	0.045
skeletal muscle organ development	GO:0060538	78	0.045	Zebrafish
lipid catabolic process	GO:0016042	4	0.045
action potential	GO:0001508	19	0.045	Worm
carboxylic acid metabolic process	GO:0019752	22	0.044
organic cyclic compound metabolic process	GO:1901360	301	0.044	Human Zebrafish Mouse Rat Worm Fly
regulation of reproductive process	GO:2000241	4	0.044
chordate embryonic development	GO:0043009	271	0.044	Zebrafish
cellular response to decreased oxygen levels	GO:0036294	1	0.044
regulation of cellular component movement	GO:0051270	55	0.044	Rat
regulation of biosynthetic process	GO:0009889	250	0.044	Mouse
regulation of striated muscle contraction	GO:0006942	2	0.043	Mouse Rat
ameboidal type cell migration	GO:0001667	143	0.043
regulation of cytoplasmic transport	GO:1903649	4	0.043
regionalization	GO:0003002	274	0.042	Zebrafish
specification of axis polarity	GO:0065001	4	0.042	Zebrafish
ear morphogenesis	GO:0042471	64	0.042	Zebrafish
glucocorticoid biosynthetic process	GO:0006704	1	0.042	Mouse
gene expression	GO:0010467	252	0.042
dorsal ventral pattern formation	GO:0009953	125	0.042
circulatory system process	GO:0003013	87	0.041	Zebrafish Mouse Rat
photoreceptor cell fate specification	GO:0043704	1	0.041
lens development in camera type eye	GO:0002088	22	0.041
cellular macromolecule metabolic process	GO:0044260	391	0.041
regulation of cellular amino acid metabolic process	GO:0006521	0	0.041
protein localization to plasma membrane	GO:0072659	1	0.041
carbohydrate derivative metabolic process	GO:1901135	61	0.040	Human Zebrafish Mouse Rat Worm Fly
programmed cell death	GO:0012501	119	0.040
otic vesicle morphogenesis	GO:0071600	34	0.040	Zebrafish
cell death	GO:0008219	121	0.040
regulation of cellular amine metabolic process	GO:0033238	0	0.039
sodium ion transmembrane transport	GO:0035725	21	0.039	Human Zebrafish Mouse Rat Worm Fly
mechanosensory lateral line system development	GO:0048881	49	0.039
inorganic cation transmembrane transport	GO:0098662	50	0.039	Human Zebrafish Mouse Rat Worm Fly
stem cell proliferation	GO:0072089	4	0.039
lateral line system development	GO:0048925	76	0.038
cell morphogenesis	GO:0000902	289	0.038	Fly
cell surface receptor signaling pathway	GO:0007166	325	0.038
regulation of protein complex assembly	GO:0043254	3	0.038
developmental programmed cell death	GO:0010623	4	0.038
cellular localization	GO:0051641	97	0.038
negative regulation of blood circulation	GO:1903523	2	0.038	Mouse
cation transmembrane transport	GO:0098655	65	0.038	Human Zebrafish Mouse Rat Worm Fly
response to stress	GO:0006950	263	0.037
response to nutrient	GO:0007584	3	0.037
stem cell differentiation	GO:0048863	117	0.037
phosphate containing compound metabolic process	GO:0006796	108	0.037	Human Zebrafish Mouse Rat Worm Fly
blood circulation	GO:0008015	87	0.036	Zebrafish Mouse Rat
nuclear transport	GO:0051169	4	0.036
nucleobase containing compound biosynthetic process	GO:0034654	205	0.036
exocytosis	GO:0006887	1	0.036
nucleocytoplasmic transport	GO:0006913	4	0.035
midbrain hindbrain boundary development	GO:0030917	23	0.035	Zebrafish
neurological system process	GO:0050877	62	0.035	Fly
photoreceptor cell fate commitment	GO:0046552	1	0.035
morphogenesis of an epithelium	GO:0002009	333	0.035	Zebrafish
peptidyl serine phosphorylation	GO:0018105	1	0.035
atp catabolic process	GO:0006200	4	0.035	Human Zebrafish Mouse Rat Worm Fly
glial cell differentiation	GO:0010001	42	0.034
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.034
protein metabolic process	GO:0019538	183	0.034	Worm
regulation of cardiac muscle cell contraction	GO:0086004	1	0.034	Rat
peptidyl serine modification	GO:0018209	2	0.034
positive regulation of cellular process	GO:0048522	201	0.034
positive regulation of striated muscle tissue development	GO:0045844	1	0.034
regulation of nucleocytoplasmic transport	GO:0046822	2	0.034
cellular transition metal ion homeostasis	GO:0046916	3	0.034
glucose homeostasis	GO:0042593	1	0.034
protein targeting to nucleus	GO:0044744	3	0.033
skeletal system development	GO:0001501	181	0.033
regulation of blood pressure	GO:0008217	1	0.033	Mouse
regulation of cell death	GO:0010941	103	0.033
cation transport	GO:0006812	81	0.033	Human Zebrafish Mouse Rat Worm Fly
somite development	GO:0061053	96	0.033
oxoacid metabolic process	GO:0043436	31	0.033
lateral line development	GO:0048882	66	0.033
tissue homeostasis	GO:0001894	25	0.033	Fly
regulation of hormone secretion	GO:0046883	2	0.033
potassium ion transport	GO:0006813	10	0.033	Human Zebrafish Mouse Rat Worm Fly
regulation of muscle contraction	GO:0006937	3	0.032	Mouse Rat Worm
camera type eye morphogenesis	GO:0048593	108	0.032
camera type eye development	GO:0043010	222	0.032
mesoderm development	GO:0007498	88	0.032
positive regulation of cytokine production	GO:0001819	2	0.032
cell projection morphogenesis	GO:0048858	244	0.031
striated muscle tissue development	GO:0014706	110	0.031	Zebrafish
cell migration involved in heart development	GO:0060973	22	0.031	Zebrafish
determination of heart left right asymmetry	GO:0061371	117	0.031	Zebrafish
neurotransmitter transport	GO:0006836	2	0.031
cellular response to steroid hormone stimulus	GO:0071383	31	0.031	Human
cellular response to endogenous stimulus	GO:0071495	68	0.031	Human
nuclear import	GO:0051170	3	0.031
startle response	GO:0001964	4	0.031
cellular response to lipid	GO:0071396	39	0.031	Human
positive regulation of multicellular organismal process	GO:0051240	52	0.030	Mouse
epithelial cell differentiation	GO:0030855	116	0.030
cellular response to hypoxia	GO:0071456	1	0.030
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.029
regulation of hormone levels	GO:0010817	21	0.029	Mouse
regulation of gene expression	GO:0010468	265	0.029
lipid storage	GO:0019915	1	0.029
multicellular organism growth	GO:0035264	4	0.029
regulation of rna metabolic process	GO:0051252	224	0.029
peptidyl threonine phosphorylation	GO:0018107	1	0.029
regulation of protein localization to nucleus	GO:1900180	2	0.029
response to inorganic substance	GO:0010035	38	0.029
regulation of skeletal muscle tissue development	GO:0048641	4	0.029
specification of symmetry	GO:0009799	204	0.029	Zebrafish
lipid metabolic process	GO:0006629	52	0.028	Mouse
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.028
apoptotic process involved in development	GO:1902742	2	0.028
epithelial tube morphogenesis	GO:0060562	148	0.028	Zebrafish
erk1 and erk2 cascade	GO:0070371	4	0.028
cellular component biogenesis	GO:0044085	178	0.028	Fly
response to hexose	GO:0009746	3	0.028
regulation of cardiac muscle contraction	GO:0055117	2	0.028	Rat
secondary metabolic process	GO:0019748	3	0.028
growth	GO:0040007	174	0.028	Worm Fly
phosphorus metabolic process	GO:0006793	109	0.028	Human Zebrafish Mouse Rat Worm Fly
anion transport	GO:0006820	38	0.028
response to hormone	GO:0009725	48	0.028	Human
nucleic acid templated transcription	GO:0097659	181	0.028
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.028
digestive system development	GO:0055123	289	0.027
response to glucocorticoid	GO:0051384	1	0.027
embryonic heart tube development	GO:0035050	133	0.027	Zebrafish
positive regulation of cellular catabolic process	GO:0031331	3	0.027
positive regulation of wound healing	GO:0090303	1	0.027
apoptotic process	GO:0006915	116	0.027
regulation of ion transmembrane transporter activity	GO:0032412	2	0.027
death	GO:0016265	121	0.027
ectodermal placode development	GO:0071696	37	0.027
regulation of primary metabolic process	GO:0080090	311	0.027	Mouse
establishment of protein localization to organelle	GO:0072594	4	0.027
response to carbohydrate	GO:0009743	3	0.027
regulation of system process	GO:0044057	40	0.027	Mouse Rat Worm
cellular potassium ion transport	GO:0071804	10	0.027	Human Zebrafish Mouse Rat Worm Fly
regulation of apoptotic process	GO:0042981	98	0.026
organelle organization	GO:0006996	227	0.026
positive regulation of muscle organ development	GO:0048636	1	0.026
regulation of multicellular organismal process	GO:0051239	277	0.026	Mouse Rat Worm
response to glucose	GO:0009749	3	0.026
regulation of actin filament based movement	GO:1903115	1	0.026	Rat
rna biosynthetic process	GO:0032774	181	0.026
embryonic pectoral fin morphogenesis	GO:0035118	24	0.026
head development	GO:0060322	303	0.026	Zebrafish
regulation of wound healing	GO:0061041	2	0.026
regulation of cell migration	GO:0030334	40	0.026
regulation of production of molecular mediator of immune response	GO:0002700	1	0.026
cytoskeleton organization	GO:0007010	96	0.025
behavior	GO:0007610	74	0.025	Zebrafish Fly
ossification	GO:0001503	23	0.025
nucleic acid metabolic process	GO:0090304	244	0.025
appendage development	GO:0048736	80	0.025
inorganic ion transmembrane transport	GO:0098660	57	0.025	Human Zebrafish Mouse Rat Worm Fly
gland development	GO:0048732	143	0.025
regulation of blood circulation	GO:1903522	32	0.025	Mouse Rat
regulation of erk1 and erk2 cascade	GO:0070372	4	0.025
skeletal muscle tissue development	GO:0007519	67	0.025	Zebrafish
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.025
response to biotic stimulus	GO:0009607	97	0.025
regulation of transcription dna templated	GO:0006355	213	0.025
sequestering of metal ion	GO:0051238	3	0.025
positive regulation of nucleotide catabolic process	GO:0030813	1	0.024
immune system process	GO:0002376	241	0.024
regulation of protein targeting	GO:1903533	2	0.024
transcription dna templated	GO:0006351	181	0.024
establishment of protein localization to plasma membrane	GO:0090002	1	0.024
apoptotic process involved in morphogenesis	GO:0060561	2	0.024
regulation of cell substrate adhesion	GO:0010810	1	0.024
nucleoside phosphate metabolic process	GO:0006753	28	0.024	Human Zebrafish Mouse Rat Worm Fly
mechanoreceptor differentiation	GO:0042490	37	0.024
regulation of i kappab kinase nf kappab signaling	GO:0043122	4	0.024
phagocytosis	GO:0006909	3	0.024
developmental growth	GO:0048589	166	0.024	Fly
meiotic cell cycle process	GO:1903046	3	0.023
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.023
eye morphogenesis	GO:0048592	144	0.023
actin filament based process	GO:0030029	64	0.023	Rat
cellular response to organic cyclic compound	GO:0071407	38	0.023	Human
regulation of circadian rhythm	GO:0042752	4	0.023
rna metabolic process	GO:0016070	219	0.023
neuromast development	GO:0048884	46	0.023
cell proliferation	GO:0008283	80	0.023
regulation of nucleoside metabolic process	GO:0009118	2	0.023
ubiquitin dependent protein catabolic process	GO:0006511	3	0.023
pancreas development	GO:0031016	84	0.023
cellular amino acid metabolic process	GO:0006520	7	0.023
rostrocaudal neural tube patterning	GO:0021903	29	0.023	Zebrafish
endocrine process	GO:0050886	2	0.023
neuron differentiation	GO:0030182	353	0.023
positive regulation of response to stimulus	GO:0048584	80	0.023
regulation of reactive oxygen species metabolic process	GO:2000377	2	0.023
positive regulation of cellular amine metabolic process	GO:0033240	0	0.022
protein secretion	GO:0009306	1	0.022
regulation of cell communication	GO:0010646	232	0.022
sensory perception of mechanical stimulus	GO:0050954	16	0.022	Fly
organelle fusion	GO:0048284	3	0.022
female sex differentiation	GO:0046660	4	0.022
regulation of cell projection assembly	GO:0060491	4	0.022
production of molecular mediator of immune response	GO:0002440	2	0.022
neuromast hair cell differentiation	GO:0048886	12	0.022
regulation of cellular ketone metabolic process	GO:0010565	7	0.022
retina morphogenesis in camera type eye	GO:0060042	79	0.022
heart morphogenesis	GO:0003007	156	0.021	Zebrafish
regulation of transmembrane transporter activity	GO:0022898	2	0.021
cellular lipid metabolic process	GO:0044255	36	0.021
macromolecule localization	GO:0033036	54	0.021
regulation of heart contraction	GO:0008016	32	0.021	Mouse Rat
oxidation reduction process	GO:0055114	41	0.021
regulation of developmental process	GO:0050793	247	0.021	Fly
negative regulation of intracellular transport	GO:0032387	3	0.021
regulation of purine nucleotide catabolic process	GO:0033121	2	0.021
myeloid cell homeostasis	GO:0002262	56	0.021
cellular response to organic substance	GO:0071310	105	0.021	Human
regulation of neurogenesis	GO:0050767	87	0.020
cardiac muscle cell contraction	GO:0086003	1	0.020	Rat
mesenchyme development	GO:0060485	127	0.020
muscle organ development	GO:0007517	101	0.020	Zebrafish
regulation of cell morphogenesis	GO:0022604	42	0.020	Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.020
water homeostasis	GO:0030104	4	0.020
single organism nuclear import	GO:1902593	3	0.020
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.020
nitrogen compound transport	GO:0071705	23	0.020
tissue remodeling	GO:0048771	4	0.020
regulation of cell activation	GO:0050865	1	0.020
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.020
regulation of cellular carbohydrate metabolic process	GO:0010675	4	0.019
development of primary female sexual characteristics	GO:0046545	4	0.019
apical junction assembly	GO:0043297	1	0.019	Fly
regulation of nucleotide catabolic process	GO:0030811	2	0.019
single organism organelle organization	GO:1902589	199	0.019
pigmentation	GO:0043473	85	0.019
negative regulation of stem cell differentiation	GO:2000737	2	0.019
exocrine system development	GO:0035272	28	0.019
regulation of epithelial cell proliferation	GO:0050678	3	0.019
gtp catabolic process	GO:0006184	2	0.019
hormone secretion	GO:0046879	2	0.019
regulation of signaling	GO:0023051	235	0.019
positive regulation of purine nucleotide catabolic process	GO:0033123	1	0.019
cellular response to radiation	GO:0071478	4	0.019
organic substance transport	GO:0071702	58	0.019
negative regulation of kinase activity	GO:0033673	4	0.019
cellular macromolecule biosynthetic process	GO:0034645	224	0.019
peptide transport	GO:0015833	1	0.019
regulation of protein import into nucleus	GO:0042306	2	0.019
negative regulation of protein phosphorylation	GO:0001933	4	0.019
limb bud formation	GO:0060174	2	0.019
protein import	GO:0017038	3	0.019
cellular protein catabolic process	GO:0044257	4	0.019
regulation of dendrite development	GO:0050773	3	0.019
neuroblast proliferation	GO:0007405	2	0.019
positive regulation of molecular function	GO:0044093	33	0.018
regulation of molecular function	GO:0065009	70	0.018
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.018
modification dependent protein catabolic process	GO:0019941	3	0.018
negative regulation of developmental process	GO:0051093	65	0.018
regulation of calcium ion transport	GO:0051924	2	0.018
regulation of transporter activity	GO:0032409	2	0.018
gliogenesis	GO:0042063	45	0.018
actin polymerization or depolymerization	GO:0008154	2	0.018
positive regulation of cell adhesion	GO:0045785	1	0.018
multi organism process	GO:0051704	134	0.018
wnt signaling pathway	GO:0016055	80	0.018
vascular endothelial growth factor receptor signaling pathway	GO:0048010	13	0.018
lymph vessel morphogenesis	GO:0036303	25	0.018
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.018
regulation of neurotransmitter secretion	GO:0046928	1	0.018
cell cell signaling	GO:0007267	52	0.018	Fly
modification dependent macromolecule catabolic process	GO:0043632	3	0.018
regulation of response to stimulus	GO:0048583	269	0.018
steroid metabolic process	GO:0008202	7	0.017	Mouse
segmentation	GO:0035282	97	0.017
rna localization	GO:0006403	4	0.017
endocrine system development	GO:0035270	65	0.017
cellular carbohydrate metabolic process	GO:0044262	4	0.017
regulation of locomotion	GO:0040012	55	0.017
carbohydrate homeostasis	GO:0033500	1	0.017
cellular component maintenance	GO:0043954	3	0.017
centrosome organization	GO:0051297	1	0.017
single organism membrane fusion	GO:0044801	2	0.017
cellular response to xenobiotic stimulus	GO:0071466	35	0.017
tyrosine phosphorylation of stat protein	GO:0007260	1	0.017
cellular component disassembly	GO:0022411	1	0.017
cell projection organization	GO:0030030	284	0.017
alcohol biosynthetic process	GO:0046165	2	0.017
heterocycle catabolic process	GO:0046700	15	0.017	Human Zebrafish Mouse Rat Worm Fly
stem cell maintenance	GO:0019827	4	0.017
inositol lipid mediated signaling	GO:0048017	2	0.017
intracellular signal transduction	GO:0035556	85	0.017
somitogenesis	GO:0001756	87	0.017
vasculogenesis	GO:0001570	41	0.017
protein import into nucleus	GO:0006606	3	0.017
positive regulation of cell cycle	GO:0045787	3	0.017
response to antibiotic	GO:0046677	1	0.017
regulation of guanylate cyclase activity	GO:0031282	6	0.017
positive regulation of muscle tissue development	GO:1901863	1	0.017
rhombomere 5 development	GO:0021571	4	0.016
regulation of ion transport	GO:0043269	22	0.016	Rat
response to other organism	GO:0051707	97	0.016
regulation of neurotransmitter transport	GO:0051588	1	0.016
rhombomere 6 development	GO:0021572	4	0.016
retina development in camera type eye	GO:0060041	146	0.016
gtp metabolic process	GO:0046039	4	0.016
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.016
regulation of cellular component organization	GO:0051128	86	0.016	Fly
response to alkaloid	GO:0043279	2	0.016
astrocyte differentiation	GO:0048708	1	0.016
cellular response to molecule of bacterial origin	GO:0071219	3	0.016
positive regulation of cytoskeleton organization	GO:0051495	3	0.016
carbohydrate biosynthetic process	GO:0016051	1	0.016
mitochondrion organization	GO:0007005	4	0.016
hormone metabolic process	GO:0042445	19	0.016	Mouse
guanosine containing compound catabolic process	GO:1901069	2	0.016
muscle structure development	GO:0061061	196	0.016	Zebrafish
central nervous system neuron development	GO:0021954	29	0.016
cell part morphogenesis	GO:0032990	246	0.016
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	2	0.016
regulation of membrane potential	GO:0042391	23	0.016	Human Rat Worm
cardiocyte differentiation	GO:0035051	44	0.016	Zebrafish
renal system process	GO:0003014	14	0.016
regulation of protein ubiquitination	GO:0031396	3	0.016
positive regulation of nucleoside metabolic process	GO:0045979	1	0.015
regulation of blood vessel size	GO:0050880	2	0.015
sodium ion transport	GO:0006814	24	0.015	Human Zebrafish Mouse Rat Worm Fly
fin morphogenesis	GO:0033334	53	0.015
chemical homeostasis	GO:0048878	49	0.015	Human Zebrafish
cilium morphogenesis	GO:0060271	85	0.015
axon ensheathment in central nervous system	GO:0032291	2	0.015
cortical actin cytoskeleton organization	GO:0030866	1	0.015
nephron morphogenesis	GO:0072028	2	0.015
cranial ganglion development	GO:0061550	3	0.015
embryonic heart tube morphogenesis	GO:0003143	108	0.015	Zebrafish
regulation of synapse assembly	GO:0051963	3	0.015
g protein coupled receptor signaling pathway	GO:0007186	74	0.015
sodium ion homeostasis	GO:0055078	3	0.015	Human
neuron development	GO:0048666	262	0.015
regulation of rna biosynthetic process	GO:2001141	213	0.015
entrainment of circadian clock	GO:0009649	2	0.015
response to hydrogen peroxide	GO:0042542	3	0.015
anterior posterior pattern specification	GO:0009952	152	0.015	Zebrafish
response to external biotic stimulus	GO:0043207	97	0.014
monovalent inorganic cation homeostasis	GO:0055067	9	0.014	Human
adult behavior	GO:0030534	2	0.014	Fly
heart process	GO:0003015	71	0.014	Zebrafish Mouse Rat
regulation of cell motility	GO:2000145	46	0.014
positive regulation of blood circulation	GO:1903524	2	0.014	Mouse
regulation of synapse organization	GO:0050807	3	0.014
response to oxygen containing compound	GO:1901700	55	0.014	Human
cortical cytoskeleton organization	GO:0030865	1	0.014
spermatid development	GO:0007286	2	0.014
anatomical structure homeostasis	GO:0060249	36	0.014	Fly
regulation of protein polymerization	GO:0032271	2	0.014
positive regulation of immune effector process	GO:0002699	3	0.014
cell fate specification	GO:0001708	68	0.014
multicellular organismal homeostasis	GO:0048871	29	0.014	Fly
cellular response to estrogen stimulus	GO:0071391	24	0.014
positive regulation of cell substrate adhesion	GO:0010811	1	0.014
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.014

atp1a1a.5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.044
cardiovascular system disease	DOID:1287	0.044
nervous system disease	DOID:863	0.018
muscular disease	DOID:0080000	0.015
myopathy	DOID:423	0.015
musculoskeletal system disease	DOID:17	0.015
muscle tissue disease	DOID:66	0.015

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