IMP: Integrative Multi-species Prediction

Danio rerio

26 known processes

atp1a1a.2

ATPase, Na+/K+ transporting, alpha 1a.2 polypeptide

(Aliases: cb703,atp[a]1A2b,zgc:110523,atp1a1l2)

ZFIN: ZDB-GENE-001212-2
Entrez: 64613
Ensembl: ENSDARG00000007739
UniProtKB: Q9DGL4

Process Predictions
Disease Predictions

atp1a1a.2 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

Filter by process size:

Biological process	GO term ID	Process size	Probability	Func Analog Org
negative regulation of heart contraction	GO:0045822	2	0.974	Mouse
regulation of sodium ion transport	GO:0002028	2	0.970	Rat
otic vesicle formation	GO:0030916	27	0.958	Zebrafish
cellular potassium ion transport	GO:0071804	10	0.953	Human Zebrafish Mouse Rat Worm Fly
otic vesicle development	GO:0071599	42	0.917	Zebrafish
ear development	GO:0043583	127	0.883
ear morphogenesis	GO:0042471	64	0.855
sensory organ development	GO:0007423	393	0.805
sodium ion transport	GO:0006814	24	0.799	Human Zebrafish Mouse Rat Worm Fly
sensory organ morphogenesis	GO:0090596	200	0.798
otolith development	GO:0048840	32	0.791	Zebrafish
monovalent inorganic cation homeostasis	GO:0055067	9	0.771	Human
otic vesicle morphogenesis	GO:0071600	34	0.761	Zebrafish
semicircular canal development	GO:0060872	24	0.742
specification of axis polarity	GO:0065001	4	0.712	Zebrafish
inorganic ion transmembrane transport	GO:0098660	57	0.691	Human Zebrafish Mouse Rat Worm Fly
larval development	GO:0002164	2	0.686	Worm
cellular sodium ion homeostasis	GO:0006883	1	0.679	Human
midbrain hindbrain boundary development	GO:0030917	23	0.665	Zebrafish
negative regulation of blood circulation	GO:1903523	2	0.628	Mouse
inner ear development	GO:0048839	126	0.590
regulation of actin filament based movement	GO:1903115	1	0.588	Rat
potassium ion transport	GO:0006813	10	0.579	Human Zebrafish Mouse Rat Worm Fly
nitrogen compound metabolic process	GO:0006807	319	0.579	Human Zebrafish Mouse Rat Worm Fly
head development	GO:0060322	303	0.556	Zebrafish
neural tube development	GO:0021915	62	0.553	Zebrafish
regionalization	GO:0003002	274	0.551	Zebrafish
regulation of cellular biosynthetic process	GO:0031326	245	0.542	Mouse
cell migration involved in heart development	GO:0060973	22	0.518	Zebrafish
fluid transport	GO:0042044	17	0.510	Zebrafish
negative regulation of biosynthetic process	GO:0009890	55	0.484	Mouse
cellular response to external stimulus	GO:0071496	2	0.482	Rat
cation transport	GO:0006812	81	0.477	Human Zebrafish Mouse Rat Worm Fly
membrane repolarization	GO:0086009	2	0.466	Human
membrane hyperpolarization	GO:0060081	1	0.457	Rat
ventricular system development	GO:0021591	12	0.451	Zebrafish
ion transmembrane transport	GO:0034220	91	0.449	Human Zebrafish Mouse Rat Worm Fly
organic cyclic compound metabolic process	GO:1901360	301	0.446	Human Zebrafish Mouse Rat Worm Fly
apical junction assembly	GO:0043297	1	0.428	Fly
response to drug	GO:0042493	3	0.406	Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.403
anterior posterior pattern specification	GO:0009952	152	0.396	Zebrafish
inner ear morphogenesis	GO:0042472	63	0.395
monovalent inorganic cation transport	GO:0015672	42	0.389	Human Zebrafish Mouse Rat Worm Fly
regulation of biological quality	GO:0065008	263	0.388	Human Zebrafish Mouse Rat Worm Fly
cellular biosynthetic process	GO:0044249	286	0.378	Mouse
heterocycle metabolic process	GO:0046483	290	0.375	Human Zebrafish Mouse Rat Worm Fly
negative regulation of cellular process	GO:0048523	283	0.373	Mouse
nucleobase containing compound metabolic process	GO:0006139	274	0.363	Human Zebrafish Mouse Rat Worm Fly
negative regulation of biological process	GO:0048519	304	0.362	Mouse
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.354	Human Zebrafish Mouse Rat Worm Fly
glucocorticoid metabolic process	GO:0008211	2	0.338	Mouse
embryonic organ morphogenesis	GO:0048562	274	0.317
regulation of biosynthetic process	GO:0009889	250	0.300	Mouse
heart morphogenesis	GO:0003007	156	0.285	Zebrafish
divalent inorganic cation homeostasis	GO:0072507	22	0.282	Zebrafish
establishment of localization	GO:0051234	244	0.282	Human Zebrafish Mouse Rat Worm Fly
regulation of hormone levels	GO:0010817	21	0.279	Mouse
atp catabolic process	GO:0006200	4	0.251	Human Zebrafish Mouse Rat Worm Fly
nucleoside monophosphate catabolic process	GO:0009125	4	0.246	Human Zebrafish Mouse Rat Worm Fly
embryonic heart tube morphogenesis	GO:0003143	108	0.242	Zebrafish
epithelial tube morphogenesis	GO:0060562	148	0.240	Zebrafish
single organism localization	GO:1902578	225	0.231	Human Zebrafish Mouse Rat Worm Fly
rna biosynthetic process	GO:0032774	181	0.231
cellular aromatic compound metabolic process	GO:0006725	295	0.226	Human Zebrafish Mouse Rat Worm Fly
cation transmembrane transport	GO:0098655	65	0.223	Human Zebrafish Mouse Rat Worm Fly
small molecule metabolic process	GO:0044281	77	0.221	Human Zebrafish Mouse Rat Worm Fly
regulation of blood circulation	GO:1903522	32	0.220	Mouse Rat
semicircular canal morphogenesis	GO:0048752	18	0.214
metal ion transport	GO:0030001	58	0.212	Human Zebrafish Mouse Rat Worm Fly
system process	GO:0003008	185	0.208	Zebrafish Mouse Rat Worm Fly
eye development	GO:0001654	277	0.208
specification of organ axis polarity	GO:0010084	2	0.202	Zebrafish
action potential	GO:0001508	19	0.202	Worm
heart development	GO:0007507	313	0.197	Zebrafish
circulatory system process	GO:0003013	87	0.195	Zebrafish Mouse Rat
transport	GO:0006810	220	0.195	Human Zebrafish Mouse Rat Worm Fly
muscle contraction	GO:0006936	18	0.194	Mouse Rat Worm
organic substance biosynthetic process	GO:1901576	289	0.193	Mouse
cellular monovalent inorganic cation homeostasis	GO:0030004	2	0.193	Human
hormone metabolic process	GO:0042445	19	0.192	Mouse
cell migration involved in heart formation	GO:0060974	10	0.179	Zebrafish
heart looping	GO:0001947	94	0.172	Zebrafish
rostrocaudal neural tube patterning	GO:0021903	29	0.166	Zebrafish
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.163
synaptic growth at neuromuscular junction	GO:0051124	2	0.162	Fly
positive regulation of blood circulation	GO:1903524	2	0.160	Mouse
lateral line system development	GO:0048925	76	0.160
regulation of anatomical structure morphogenesis	GO:0022603	130	0.160	Fly
regulation of metal ion transport	GO:0010959	4	0.158	Rat
stem cell differentiation	GO:0048863	117	0.155
homeostatic process	GO:0042592	142	0.154	Human Zebrafish Fly
otic placode formation	GO:0043049	23	0.153
embryonic organ development	GO:0048568	381	0.151
determination of heart left right asymmetry	GO:0061371	117	0.150	Zebrafish
epidermal cell fate specification	GO:0009957	4	0.149
chemical homeostasis	GO:0048878	49	0.148	Human Zebrafish
embryo development ending in birth or egg hatching	GO:0009792	271	0.147	Zebrafish Worm Fly
ammonia homeostasis	GO:0097272	3	0.143
cellular nitrogen compound metabolic process	GO:0034641	290	0.142	Human Zebrafish Mouse Rat Worm Fly
cellular component biogenesis	GO:0044085	178	0.136	Fly
stem cell maintenance	GO:0019827	4	0.135
brain development	GO:0007420	293	0.134	Zebrafish
central nervous system development	GO:0007417	387	0.133	Zebrafish
response to organic substance	GO:0010033	153	0.132	Human
retina development in camera type eye	GO:0060041	146	0.132
stem cell development	GO:0048864	82	0.130
regulation of membrane potential	GO:0042391	23	0.129	Human Rat Worm
positive regulation of tyrosine phosphorylation of stat protein	GO:0042531	1	0.128
regulation of blood pressure	GO:0008217	1	0.126	Mouse
regulation of rna metabolic process	GO:0051252	224	0.125
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.125	Human Zebrafish Mouse Rat Worm Fly
chordate embryonic development	GO:0043009	271	0.122	Zebrafish
morphogenesis of an epithelium	GO:0002009	333	0.120	Zebrafish
regulation of heart contraction	GO:0008016	32	0.120	Mouse Rat
negative regulation of metabolic process	GO:0009892	86	0.120	Mouse
aging	GO:0007568	2	0.118	Fly
cardiac muscle cell contraction	GO:0086003	1	0.118	Rat
actin mediated cell contraction	GO:0070252	1	0.118	Rat
pigmentation	GO:0043473	85	0.116
kidney development	GO:0001822	92	0.116
sympathetic nervous system development	GO:0048485	3	0.116
regulation of primary metabolic process	GO:0080090	311	0.114	Mouse
axon ensheathment in central nervous system	GO:0032291	2	0.110
sodium ion transmembrane transport	GO:0035725	21	0.108	Human Zebrafish Mouse Rat Worm Fly
regulation of rna biosynthetic process	GO:2001141	213	0.105
organonitrogen compound metabolic process	GO:1901564	74	0.105	Human Zebrafish Mouse Rat Worm Fly
cellular response to endogenous stimulus	GO:0071495	68	0.105	Human
cellular response to hormone stimulus	GO:0032870	39	0.103	Human
central nervous system myelin formation	GO:0032289	1	0.101
regulation of nitrogen compound metabolic process	GO:0051171	251	0.101
generation of neurons	GO:0048699	385	0.100
axis specification	GO:0009798	43	0.099	Zebrafish
ameboidal type cell migration	GO:0001667	143	0.099
cell motility	GO:0048870	244	0.099	Zebrafish
inorganic cation transmembrane transport	GO:0098662	50	0.098	Human Zebrafish Mouse Rat Worm Fly
negative regulation of protein phosphorylation	GO:0001933	4	0.098
single organism transport	GO:0044765	206	0.096	Human Zebrafish Mouse Rat Worm Fly
neural crest cell migration	GO:0001755	42	0.096
tube morphogenesis	GO:0035239	349	0.096
protein localization to nucleus	GO:0034504	3	0.095
hormone biosynthetic process	GO:0042446	3	0.094	Mouse
regulation of cardiac muscle contraction	GO:0055117	2	0.092	Rat
cardiocyte differentiation	GO:0035051	44	0.092	Zebrafish
regulation of developmental process	GO:0050793	247	0.091	Fly
specification of symmetry	GO:0009799	204	0.091	Zebrafish
regulation of vascular permeability	GO:0043114	5	0.091
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.090
rna metabolic process	GO:0016070	219	0.089
ion transport	GO:0006811	114	0.089	Human Zebrafish Mouse Rat Worm Fly
mesoderm morphogenesis	GO:0048332	51	0.088
adult behavior	GO:0030534	2	0.087	Fly
growth	GO:0040007	174	0.087	Worm Fly
cellular amino acid metabolic process	GO:0006520	7	0.085
regulation of ph	GO:0006885	3	0.085
ion homeostasis	GO:0050801	41	0.084	Human Zebrafish
regulation of macromolecule metabolic process	GO:0060255	317	0.084
cellular response to extracellular stimulus	GO:0031668	2	0.081
cartilage development	GO:0051216	96	0.079
regulation of striated muscle contraction	GO:0006942	2	0.077	Mouse Rat
muscle organ development	GO:0007517	101	0.077	Zebrafish
transcription from rna polymerase ii promoter	GO:0006366	80	0.076
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.076
anion homeostasis	GO:0055081	9	0.075
central nervous system myelination	GO:0022010	2	0.074
potassium ion transmembrane transport	GO:0071805	10	0.073	Human Zebrafish Mouse Rat Worm Fly
mesenchymal cell differentiation	GO:0048762	87	0.073
regulation of macromolecule biosynthetic process	GO:0010556	225	0.073
heart contraction	GO:0060047	71	0.070	Zebrafish Mouse Rat
lens morphogenesis in camera type eye	GO:0002089	7	0.068
embryonic heart tube development	GO:0035050	133	0.068	Zebrafish
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.068
regulation of system process	GO:0044057	40	0.068	Mouse Rat Worm
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.067
cellular macromolecule biosynthetic process	GO:0034645	224	0.066
sodium ion homeostasis	GO:0055078	3	0.065	Human
enteric nervous system development	GO:0048484	12	0.065
response to stress	GO:0006950	263	0.065
organic acid metabolic process	GO:0006082	31	0.064
positive regulation of heart contraction	GO:0045823	2	0.063	Mouse
response to endogenous stimulus	GO:0009719	83	0.063	Human
organic cyclic compound biosynthetic process	GO:1901362	223	0.062	Mouse
macromolecule biosynthetic process	GO:0009059	227	0.062
ectodermal placode morphogenesis	GO:0071697	32	0.060
renal system development	GO:0072001	94	0.059
neural plate anterior posterior regionalization	GO:0021999	8	0.059
lens development in camera type eye	GO:0002088	22	0.059
epithelial cell differentiation	GO:0030855	116	0.059
regulation of gene expression	GO:0010468	265	0.059
regulation of ion transport	GO:0043269	22	0.058	Rat
regulation of sequestering of calcium ion	GO:0051282	4	0.058
multicellular organismal homeostasis	GO:0048871	29	0.058	Fly
amine metabolic process	GO:0009308	2	0.057
transmembrane transport	GO:0055085	120	0.057	Human Zebrafish Mouse Rat Worm Fly
regulation of cellular metabolic process	GO:0031323	320	0.057	Mouse
muscle tissue development	GO:0060537	110	0.056	Zebrafish
regulation of organ morphogenesis	GO:2000027	35	0.056
somatic stem cell maintenance	GO:0035019	1	0.056
cranial ganglion development	GO:0061550	3	0.055
protein targeting to nucleus	GO:0044744	3	0.055
gene expression	GO:0010467	252	0.054
water homeostasis	GO:0030104	4	0.054
positive regulation of rna metabolic process	GO:0051254	59	0.054
hormone transport	GO:0009914	2	0.054
blood circulation	GO:0008015	87	0.053	Zebrafish Mouse Rat
cation homeostasis	GO:0055080	33	0.052	Human Zebrafish
cellular response to lipid	GO:0071396	39	0.052	Human
sensory perception of sound	GO:0007605	9	0.051	Fly
positive regulation of canonical wnt signaling pathway	GO:0090263	4	0.050
positive regulation of biological process	GO:0048518	253	0.050	Mouse
positive regulation of cellular biosynthetic process	GO:0031328	68	0.049
mesenchyme development	GO:0060485	127	0.049
mesenchymal cell development	GO:0014031	78	0.049
extrinsic apoptotic signaling pathway	GO:0097191	3	0.048
transcription dna templated	GO:0006351	181	0.048
pectoral fin development	GO:0033339	50	0.048
regulation of cellular amino acid metabolic process	GO:0006521	0	0.048
somite development	GO:0061053	96	0.048
embryonic digestive tract development	GO:0048566	4	0.047
cellular ketone metabolic process	GO:0042180	11	0.047
nephron epithelium morphogenesis	GO:0072088	1	0.046
neural tube patterning	GO:0021532	33	0.046	Zebrafish
tissue homeostasis	GO:0001894	25	0.046	Fly
locomotion	GO:0040011	313	0.046	Zebrafish
positive regulation of biosynthetic process	GO:0009891	68	0.046
regulation of nucleic acid templated transcription	GO:1903506	213	0.045
cardiac muscle contraction	GO:0060048	6	0.045	Rat
cell migration	GO:0016477	237	0.044	Zebrafish
carboxylic acid metabolic process	GO:0019752	22	0.044
nucleic acid metabolic process	GO:0090304	244	0.043
camera type eye development	GO:0043010	222	0.043
ammonium transmembrane transport	GO:0072488	2	0.043
regulation of cellular component movement	GO:0051270	55	0.043	Rat
cellular component assembly	GO:0022607	170	0.043	Fly
glucocorticoid biosynthetic process	GO:0006704	1	0.043	Mouse
positive regulation of transport	GO:0051050	2	0.043
oxoacid metabolic process	GO:0043436	31	0.043
urogenital system development	GO:0001655	97	0.043
cellular response to organic substance	GO:0071310	105	0.042	Human
negative regulation of mitosis	GO:0045839	3	0.042
axial mesoderm development	GO:0048318	10	0.042
negative regulation of cellular metabolic process	GO:0031324	77	0.042	Mouse
myelin assembly	GO:0032288	1	0.042
amide transport	GO:0042886	12	0.041
developmental pigmentation	GO:0048066	48	0.041
neural crest cell differentiation	GO:0014033	72	0.041
cellular component morphogenesis	GO:0032989	336	0.039	Fly
segmentation	GO:0035282	97	0.039
regulation of establishment of protein localization	GO:0070201	4	0.039
catecholamine biosynthetic process	GO:0042423	2	0.039
phenol containing compound biosynthetic process	GO:0046189	4	0.039
embryonic digestive tract morphogenesis	GO:0048557	3	0.039
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.038
response to oxygen containing compound	GO:1901700	55	0.038	Human
muscle structure development	GO:0061061	196	0.037	Zebrafish
lateral line ganglion development	GO:0048890	2	0.037
regulation of signaling	GO:0023051	235	0.037
response to hormone	GO:0009725	48	0.037	Human
positive regulation of gene expression	GO:0010628	71	0.037
synapse organization	GO:0050808	21	0.037	Fly
glial cell development	GO:0021782	20	0.036
cellular response to steroid hormone stimulus	GO:0071383	31	0.036	Human
nucleobase containing compound biosynthetic process	GO:0034654	205	0.035
camera type eye morphogenesis	GO:0048593	108	0.035
thigmotaxis	GO:0001966	5	0.035	Zebrafish
cellular amine metabolic process	GO:0044106	2	0.035
peripheral nervous system development	GO:0007422	55	0.035
neurological system process	GO:0050877	62	0.035	Fly
neural crest cell development	GO:0014032	62	0.035
hatching gland development	GO:0048785	3	0.035
cellular component movement	GO:0006928	335	0.034	Zebrafish Rat
regulation of tyrosine phosphorylation of stat protein	GO:0042509	1	0.034
negative regulation of endothelial cell migration	GO:0010596	1	0.034
dopamine biosynthetic process	GO:0042416	2	0.034
negative regulation of apoptotic process	GO:0043066	55	0.034
regulation of calcium ion transport	GO:0051924	2	0.034
floor plate development	GO:0033504	15	0.034
regulation of transcription dna templated	GO:0006355	213	0.033
ectodermal placode development	GO:0071696	37	0.033
epidermal cell differentiation	GO:0009913	36	0.033
regulation of transport	GO:0051049	45	0.033	Rat
vascular endothelial growth factor receptor signaling pathway	GO:0048010	13	0.033
regulation of cellular component organization	GO:0051128	86	0.033	Fly
female sex differentiation	GO:0046660	4	0.033
regulation of cellular response to growth factor stimulus	GO:0090287	35	0.033
regulation of multicellular organismal process	GO:0051239	277	0.033	Mouse Rat Worm
hormone secretion	GO:0046879	2	0.033
eye morphogenesis	GO:0048592	144	0.032
cell junction organization	GO:0034330	11	0.032	Fly
cell surface receptor signaling pathway	GO:0007166	325	0.032
biosynthetic process	GO:0009058	294	0.032	Mouse
pronephros development	GO:0048793	69	0.031
cellular response to chemical stimulus	GO:0070887	157	0.031	Human
localization of cell	GO:0051674	244	0.031	Zebrafish
lipid catabolic process	GO:0016042	4	0.031
monovalent inorganic anion homeostasis	GO:0055083	6	0.031
cellular response to organic cyclic compound	GO:0071407	38	0.031	Human
positive regulation of transcription dna templated	GO:0045893	57	0.031
erythrocyte homeostasis	GO:0034101	55	0.030
response to lipid	GO:0033993	60	0.030	Human
stem cell proliferation	GO:0072089	4	0.030
determination of bilateral symmetry	GO:0009855	204	0.030	Zebrafish
heterocycle catabolic process	GO:0046700	15	0.030	Human Zebrafish Mouse Rat Worm Fly
regulation of catalytic activity	GO:0050790	55	0.029
endocrine system development	GO:0035270	65	0.029
single organism metabolic process	GO:0044710	217	0.029	Human Zebrafish Mouse Rat Worm Fly
regulation of transporter activity	GO:0032409	2	0.029
maintenance of location	GO:0051235	4	0.029
negative regulation of map kinase activity	GO:0043407	2	0.029
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.029
regulation of metabolic process	GO:0019222	359	0.028	Mouse
pigment cell differentiation	GO:0050931	38	0.028
response to chemical	GO:0042221	320	0.028	Human Mouse
response to organic cyclic compound	GO:0014070	51	0.028	Human
ectodermal placode formation	GO:0060788	26	0.028
purine containing compound metabolic process	GO:0072521	29	0.028	Human Zebrafish Mouse Rat Worm Fly
nucleic acid templated transcription	GO:0097659	181	0.028
protein import into nucleus	GO:0006606	3	0.028
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.027	Human Zebrafish Mouse Rat Worm Fly
negative regulation of extrinsic apoptotic signaling pathway	GO:2001237	2	0.027
nephron morphogenesis	GO:0072028	2	0.027
regulation of cell morphogenesis	GO:0022604	42	0.027	Fly
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.027
positive regulation of metabolic process	GO:0009893	108	0.027
extracellular matrix organization	GO:0030198	27	0.027	Zebrafish
purine ribonucleotide metabolic process	GO:0009150	27	0.027	Human Zebrafish Mouse Rat Worm Fly
nephron epithelium development	GO:0072009	16	0.027
negative regulation of macromolecule metabolic process	GO:0010605	76	0.026
heart process	GO:0003015	71	0.026	Zebrafish Mouse Rat
extracellular structure organization	GO:0043062	27	0.026	Zebrafish
connective tissue development	GO:0061448	99	0.025
positive regulation of tyrosine phosphorylation of stat3 protein	GO:0042517	1	0.025
cellular nitrogen compound catabolic process	GO:0044270	15	0.025	Human Zebrafish Mouse Rat Worm Fly
lateral line nerve development	GO:0048892	9	0.025
regulation of reproductive process	GO:2000241	4	0.024
nucleoside phosphate metabolic process	GO:0006753	28	0.024	Human Zebrafish Mouse Rat Worm Fly
lipid metabolic process	GO:0006629	52	0.024	Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.024
negative regulation of transcription dna templated	GO:0045892	45	0.023
regulation of programmed cell death	GO:0043067	101	0.023
regulation of apoptotic process	GO:0042981	98	0.023
regulation of lipid biosynthetic process	GO:0046890	8	0.023	Mouse
cytokinesis	GO:0000910	3	0.023
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.023
regulation of tube size	GO:0035150	2	0.023	Fly
taxis	GO:0042330	109	0.023	Zebrafish
muscle system process	GO:0003012	20	0.023	Mouse Rat Worm
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001240	1	0.023
death	GO:0016265	121	0.022
skeletal system morphogenesis	GO:0048705	102	0.022
somitogenesis	GO:0001756	87	0.022
skeletal system development	GO:0001501	181	0.022
vasculature development	GO:0001944	278	0.022
regulation of epithelial cell proliferation	GO:0050678	3	0.022
catechol containing compound metabolic process	GO:0009712	2	0.022
regulation of localization	GO:0032879	104	0.022	Rat
carbohydrate derivative metabolic process	GO:1901135	61	0.022	Human Zebrafish Mouse Rat Worm Fly
regulation of cytoplasmic transport	GO:1903649	4	0.022
skeletal muscle tissue development	GO:0007519	67	0.022	Zebrafish
response to glucose	GO:0009749	3	0.021
regulation of cardiac muscle cell contraction	GO:0086004	1	0.021	Rat
protein import	GO:0017038	3	0.021
signal transduction	GO:0007165	455	0.021
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.021
phosphate containing compound metabolic process	GO:0006796	108	0.021	Human Zebrafish Mouse Rat Worm Fly
cellular macromolecule metabolic process	GO:0044260	391	0.021
response to steroid hormone	GO:0048545	35	0.021	Human
skeletal muscle organ development	GO:0060538	78	0.021	Zebrafish
regulation of cellular amine metabolic process	GO:0033238	0	0.021
cell part morphogenesis	GO:0032990	246	0.021
catechol containing compound biosynthetic process	GO:0009713	2	0.021
regulation of sodium ion transmembrane transport	GO:1902305	1	0.020
apoptotic process	GO:0006915	116	0.020
heterocycle biosynthetic process	GO:0018130	215	0.020
autonomic nervous system development	GO:0048483	19	0.020
catabolic process	GO:0009056	32	0.020	Human Zebrafish Mouse Rat Worm Fly
regulation of cellular protein metabolic process	GO:0032268	52	0.020
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.020
endoderm development	GO:0007492	49	0.020
organelle fusion	GO:0048284	3	0.020
hepaticobiliary system development	GO:0061008	98	0.020
digestive tract development	GO:0048565	265	0.020
positive regulation of nucleotide catabolic process	GO:0030813	1	0.019
regulation of jun kinase activity	GO:0043506	3	0.019
regulation of muscle system process	GO:0090257	5	0.019	Mouse Rat Worm
cellular catabolic process	GO:0044248	27	0.019	Human Zebrafish Mouse Rat Worm Fly
internal protein amino acid acetylation	GO:0006475	2	0.019
sequestering of metal ion	GO:0051238	3	0.019
programmed cell death	GO:0012501	119	0.019
body morphogenesis	GO:0010171	16	0.019	Zebrafish
embryonic skeletal system morphogenesis	GO:0048704	93	0.019
cell death	GO:0008219	121	0.019
protein acetylation	GO:0006473	2	0.019
gliogenesis	GO:0042063	45	0.018
cell cell signaling	GO:0007267	52	0.018	Fly
axial mesoderm morphogenesis	GO:0048319	8	0.018
neuromuscular junction development	GO:0007528	9	0.018	Fly
negative regulation of blood vessel endothelial cell migration	GO:0043537	1	0.018
developmental growth	GO:0048589	166	0.018	Fly
neuron differentiation	GO:0030182	353	0.018
axis elongation	GO:0003401	31	0.018
tissue regeneration	GO:0042246	74	0.018
internal peptidyl lysine acetylation	GO:0018393	2	0.018
dopamine metabolic process	GO:0042417	2	0.018
negative regulation of cell death	GO:0060548	60	0.018
positive regulation of cellular process	GO:0048522	201	0.018
response to carbohydrate	GO:0009743	3	0.018
regulation of cell shape	GO:0008360	1	0.018	Fly
small molecule catabolic process	GO:0044282	3	0.017
melanocyte differentiation	GO:0030318	26	0.017
organelle organization	GO:0006996	227	0.017
locomotory behavior	GO:0007626	34	0.017	Zebrafish Fly
negative regulation of rna metabolic process	GO:0051253	48	0.017
renal tubule morphogenesis	GO:0061333	1	0.017
positive regulation of cell adhesion	GO:0045785	1	0.017
protein localization to plasma membrane	GO:0072659	1	0.017
oligodendrocyte development	GO:0014003	7	0.017
positive regulation of translation	GO:0045727	1	0.017
determination of left right symmetry	GO:0007368	179	0.017	Zebrafish
regulation of protein localization to nucleus	GO:1900180	2	0.017
regulation of cell death	GO:0010941	103	0.017
regulation of cellular ketone metabolic process	GO:0010565	7	0.016
striated muscle tissue development	GO:0014706	110	0.016	Zebrafish
positive regulation of lipid metabolic process	GO:0045834	1	0.016
meiotic cell cycle process	GO:1903046	3	0.016
cellular response to abiotic stimulus	GO:0071214	4	0.016	Rat
angiogenesis	GO:0001525	158	0.016
nucleobase containing compound catabolic process	GO:0034655	15	0.016	Human Zebrafish Mouse Rat Worm Fly
immunoglobulin mediated immune response	GO:0016064	3	0.016
neuronal action potential	GO:0019228	18	0.016
response to ketone	GO:1901654	1	0.016
type b pancreatic cell development	GO:0003323	4	0.016
establishment of protein localization to organelle	GO:0072594	4	0.016
peptidyl lysine acetylation	GO:0018394	2	0.015
regulation of protein transport	GO:0051223	3	0.015
regulation of ion transmembrane transporter activity	GO:0032412	2	0.015
phosphorus metabolic process	GO:0006793	109	0.015	Human Zebrafish Mouse Rat Worm Fly
transmission of nerve impulse	GO:0019226	19	0.015
mesoderm development	GO:0007498	88	0.015
negative regulation of kinase activity	GO:0033673	4	0.015
release of sequestered calcium ion into cytosol	GO:0051209	3	0.015
regulation of cellular ph	GO:0030641	1	0.015
positive regulation of multicellular organismal process	GO:0051240	52	0.015	Mouse
regulation of hormone secretion	GO:0046883	2	0.015
steroid biosynthetic process	GO:0006694	5	0.015	Mouse
negative regulation of protein metabolic process	GO:0051248	16	0.015
negative regulation of gene expression	GO:0010629	65	0.015
lateral line nerve glial cell differentiation	GO:0048895	6	0.014
regulation of intracellular protein transport	GO:0033157	3	0.014
inorganic anion transport	GO:0015698	25	0.014
nucleoside metabolic process	GO:0009116	11	0.014	Human Zebrafish Mouse Rat Worm Fly
positive regulation of purine nucleotide catabolic process	GO:0033123	1	0.014
response to hexose	GO:0009746	3	0.014
cell morphogenesis	GO:0000902	289	0.014	Fly
protein acylation	GO:0043543	3	0.014
retina morphogenesis in camera type eye	GO:0060042	79	0.014
single organism biosynthetic process	GO:0044711	71	0.014	Mouse
single organism catabolic process	GO:0044712	13	0.014	Human Zebrafish Mouse Rat Worm Fly
response to growth factor	GO:0070848	39	0.014
negative regulation of multicellular organismal process	GO:0051241	69	0.014	Mouse
neurotransmitter transport	GO:0006836	2	0.014
protein metabolic process	GO:0019538	183	0.014	Worm
immune system development	GO:0002520	191	0.014
actin filament based process	GO:0030029	64	0.014	Rat
cell cell junction organization	GO:0045216	10	0.014	Fly
cellular cation homeostasis	GO:0030003	17	0.014	Human Zebrafish
auditory receptor cell fate commitment	GO:0009912	4	0.014
gas transport	GO:0015669	3	0.014
negative regulation of protein kinase activity	GO:0006469	4	0.014
apoptotic process involved in development	GO:1902742	2	0.013
positive regulation of catabolic process	GO:0009896	4	0.013
lens fiber cell development	GO:0070307	3	0.013
negative regulation of reproductive process	GO:2000242	3	0.013
smooth muscle contraction	GO:0006939	2	0.013
modification of morphology or physiology of other organism involved in symbiotic interaction	GO:0051817	4	0.013
organic cyclic compound catabolic process	GO:1901361	15	0.013	Human Zebrafish Mouse Rat Worm Fly
peptide transport	GO:0015833	1	0.013
actin filament based movement	GO:0030048	1	0.013	Rat
embryonic skeletal system development	GO:0048706	97	0.013
positive regulation of cellular catabolic process	GO:0031331	3	0.013
negative regulation of stem cell differentiation	GO:2000737	2	0.013
negative regulation of mapk cascade	GO:0043409	4	0.013
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.013
positive regulation of rna biosynthetic process	GO:1902680	57	0.013
alpha amino acid metabolic process	GO:1901605	3	0.013
phagocytosis	GO:0006909	3	0.013
synaptic transmission	GO:0007268	35	0.013	Fly
female gonad development	GO:0008585	4	0.013
divalent inorganic anion homeostasis	GO:0072505	5	0.013
epithelial cell proliferation	GO:0050673	17	0.012
regulation of cell activation	GO:0050865	1	0.012

atp1a1a.2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
immune system disease	DOID:2914	0.079
disease of anatomical entity	DOID:7	0.079
musculoskeletal system disease	DOID:17	0.015
cancer	DOID:162	0.013
disease of cellular proliferation	DOID:14566	0.013
organ system cancer	DOID:0050686	0.013

Loading network...

Network Filters

Minimum relationship confidence:

Maximum number of genes:

Highlight known relationships in gold.

Graphical Options

Adjust edge length:

Adjust node size:

Fixed layout

Black background

Low confidence color:

Med confidence color:

High confidence color:

Hide the legend in the network