Danio rerio

37 known processes

crbn

cereblon

(Aliases: zgc:92404)

crbn biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
head developmentGO:00603223030.106
sensory organ developmentGO:00074233930.075
nucleobase containing compound metabolic processGO:00061392740.074
cellular aromatic compound metabolic processGO:00067252950.071
embryonic organ morphogenesisGO:00485622740.065
larval developmentGO:000216420.064
organic substance biosynthetic processGO:19015762890.060
cognitionGO:005089010.060
regulation of metal ion transportGO:001095940.059
positive regulation of catabolic processGO:000989640.055
nitrogen compound metabolic processGO:00068073190.055
cellular response to external stimulusGO:007149620.055
heart developmentGO:00075073130.055
agingGO:000756820.054
organic cyclic compound metabolic processGO:19013603010.052
cellular biosynthetic processGO:00442492860.052
regulation of nitrogen compound metabolic processGO:00511712510.049
maintenance of locationGO:005123540.049
multicellular organism growthGO:003526440.047
signal transductionGO:00071654550.046
cellular macromolecule metabolic processGO:00442603910.046
cell morphogenesisGO:00009022890.046
regulation of primary metabolic processGO:00800903110.046
cellular protein catabolic processGO:004425740.046
regulation of multicellular organism growthGO:004001440.046
biosynthetic processGO:00090582940.045
regulation of multicellular organismal processGO:00512392770.044
heterocycle metabolic processGO:00464832900.043
cellular nitrogen compound metabolic processGO:00346412900.043
positive regulation of biological processGO:00485182530.042
positive regulation of transportGO:005105020.042
cellular response to extracellular stimulusGO:003166820.041
embryonic organ developmentGO:00485683810.041
regulation of synapse organizationGO:005080730.041
single organism metabolic processGO:00447102170.040
regulation of response to stimulusGO:00485832690.040
protein localization to nucleusGO:003450430.039
regionalizationGO:00030022740.039
regulation of nucleobase containing compound metabolic processGO:00192192500.039
negative regulation of biological processGO:00485193040.038
regulation of protein transportGO:005122330.038
regulation of cellular metabolic processGO:00313233200.038
negative regulation of protein phosphorylationGO:000193340.038
tube morphogenesisGO:00352393490.038
positive regulation of cellular processGO:00485222010.038
regulation of signal transductionGO:00099662250.037
central nervous system developmentGO:00074173870.036
gene expressionGO:00104672520.036
nucleobase containing compound biosynthetic processGO:00346542050.036
positive regulation of cellular component biogenesisGO:004408930.036
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.036
proteolysis involved in cellular protein catabolic processGO:005160330.036
digestive system developmentGO:00551232890.035
generation of neuronsGO:00486993850.035
regulation of gene expressionGO:00104682650.035
cilium assemblyGO:0042384580.035
nuclear transportGO:005116940.034
small molecule metabolic processGO:0044281770.033
negative regulation of cellular processGO:00485232830.033
rna metabolic processGO:00160702190.033
cell part morphogenesisGO:00329902460.033
response to chemicalGO:00422213200.033
cellular response to nutrient levelsGO:003166920.033
ubiquitin dependent protein catabolic processGO:000651130.033
neuron differentiationGO:00301823530.032
sensory organ morphogenesisGO:00905962000.032
regulation of protein catabolic processGO:004217610.032
organic cyclic compound biosynthetic processGO:19013622230.032
response to stressGO:00069502630.032
hepaticobiliary system developmentGO:0061008980.032
single organism transportGO:00447652060.031
regulation of establishment of protein localizationGO:007020140.031
cilium morphogenesisGO:0060271850.031
single organism localizationGO:19025782250.031
amine metabolic processGO:000930820.031
proteasomal protein catabolic processGO:001049820.031
cytokinesisGO:000091030.031
heterocycle biosynthetic processGO:00181302150.030
eye developmentGO:00016542770.030
positive regulation of cellular catabolic processGO:003133130.030
cell projection organizationGO:00300302840.030
modification dependent protein catabolic processGO:001994130.029
cellular component morphogenesisGO:00329893360.029
regulation of calcium ion transportGO:005192420.028
cellular nitrogen compound biosynthetic processGO:00442712180.028
regulation of intracellular protein transportGO:003315730.028
regulation of macromolecule metabolic processGO:00602553170.028
autophagyGO:000691440.028
blood vessel developmentGO:00015682460.028
regulation of neural precursor cell proliferationGO:200017730.027
response to organic substanceGO:00100331530.027
regulation of protein complex assemblyGO:004325430.027
modification dependent macromolecule catabolic processGO:004363230.027
organonitrogen compound metabolic processGO:1901564740.027
brain developmentGO:00074202930.027
regulation of cytokine productionGO:000181730.027
regulation of cytoplasmic transportGO:190364940.027
establishment of protein localization to organelleGO:007259440.027
response to drugGO:004249330.027
vasculature developmentGO:00019442780.027
cell surface receptor signaling pathwayGO:00071663250.026
immune system processGO:00023762410.026
regulation of cellular biosynthetic processGO:00313262450.026
cellular response to starvationGO:000926710.026
organelle organizationGO:00069962270.026
cilium organizationGO:0044782710.026
regulation of signalingGO:00230512350.026
regulation of protein targetingGO:190353320.026
regulation of synaptic plasticityGO:004816710.026
meiotic nuclear divisionGO:000712640.026
cellular amine metabolic processGO:004410620.026
regulation of epithelial cell proliferationGO:005067830.026
gland developmentGO:00487321430.025
regulation of bindingGO:005109830.025
macromolecule biosynthetic processGO:00090592270.025
eye morphogenesisGO:00485921440.025
nucleic acid metabolic processGO:00903042440.025
gtp catabolic processGO:000618420.025
oxoacid metabolic processGO:0043436310.024
cellular response to chemical stimulusGO:00708871570.024
gastrulationGO:00073692080.024
synaptic vesicle localizationGO:009747910.024
morphogenesis of an epitheliumGO:00020093330.024
phagocytosisGO:000690930.024
liver developmentGO:0001889960.024
digestive tract developmentGO:00485652650.024
determination of left right symmetryGO:00073681790.024
regulation of protein localization to nucleusGO:190018020.024
regulation of autophagyGO:001050630.023
regulation of cell communicationGO:00106462320.023
regulation of nucleocytoplasmic transportGO:004682220.023
regulation of metabolic processGO:00192223590.023
cellular component assemblyGO:00226071700.023
nucleocytoplasmic transportGO:000691340.023
guanosine containing compound catabolic processGO:190106920.023
regulation of synapse assemblyGO:005196330.023
locomotor rhythmGO:004547530.023
organic acid metabolic processGO:0006082310.023
angiogenesisGO:00015251580.023
blood vessel morphogenesisGO:00485142160.022
lipid storageGO:001991510.022
gtp metabolic processGO:004603940.022
negative regulation of protein localization to nucleusGO:190018120.022
mitochondrion organizationGO:000700540.022
positive regulation of secretionGO:005104710.021
regulation of nucleoside metabolic processGO:000911820.021
protein targeting to nucleusGO:004474430.021
response to carbohydrateGO:000974330.021
regulation of cell activationGO:005086510.021
positive regulation of cell cycleGO:004578730.021
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.021
chordate embryonic developmentGO:00430092710.021
cell substrate adhesionGO:003158940.021
response to external stimulusGO:00096052640.021
regulation of sequestering of calcium ionGO:005128240.021
regulation of rna metabolic processGO:00512522240.020
synaptic growth at neuromuscular junctionGO:005112420.020
regulation of transmembrane transporter activityGO:002289820.020
stem cell maintenanceGO:001982740.020
negative regulation of response to stimulusGO:00485851040.020
regulation of transcription dna templatedGO:00063552130.020
regulation of synaptic growth at neuromuscular junctionGO:000858210.020
regulation of cellular macromolecule biosynthetic processGO:20001122220.020
cellular component biogenesisGO:00440851780.020
transportGO:00068102200.020
cellular component movementGO:00069283350.020
tissue remodelingGO:004877140.020
rna biosynthetic processGO:00327741810.020
neuron neuron synaptic transmissionGO:000727010.019
determination of bilateral symmetryGO:00098552040.019
response to monosaccharideGO:003428430.019
protein acetylationGO:000647320.019
negative regulation of kinase activityGO:003367340.019
synaptic vesicle transportGO:004848910.019
extrinsic apoptotic signaling pathwayGO:009719130.019
single organism nuclear importGO:190259330.019
regulation of reproductive processGO:200024140.019
primary neural tube formationGO:001402010.019
peptide transportGO:001583310.019
positive regulation of secretion by cellGO:190353210.019
regulation of biosynthetic processGO:00098892500.019
atp catabolic processGO:000620040.019
peptidyl serine phosphorylationGO:001810510.019
peptidyl lysine acetylationGO:001839420.019
regulation of programmed cell deathGO:00430671010.019
regulation of transporter activityGO:003240920.019
cellular response to radiationGO:007147840.018
cell morphogenesis involved in differentiationGO:00009041950.018
protein importGO:001703830.018
establishment of localizationGO:00512342440.018
deathGO:00162651210.018
regulation of nucleic acid templated transcriptionGO:19035062130.018
positive regulation of epithelial cell proliferationGO:005067910.018
regulation of inflammatory responseGO:005072720.018
female sex differentiationGO:004666040.018
programmed cell deathGO:00125011190.018
positive regulation of dna metabolic processGO:005105410.018
leukocyte proliferationGO:007066110.018
guanosine containing compound metabolic processGO:190106840.018
cell deathGO:00082191210.018
regulation of protein import into nucleusGO:004230620.018
developmental growthGO:00485891660.018
i kappab kinase nf kappab signalingGO:000724940.018
positive regulation of cytoskeleton organizationGO:005149530.018
growthGO:00400071740.018
internal protein amino acid acetylationGO:000647520.018
regulation of nucleotide catabolic processGO:003081120.018
mononuclear cell proliferationGO:003294310.018
positive regulation of cell activationGO:005086710.018
protein import into nucleusGO:000660630.018
carboxylic acid metabolic processGO:0019752220.018
nucleic acid templated transcriptionGO:00976591810.018
response to abiotic stimulusGO:00096281220.018
cellular protein metabolic processGO:00442671290.018
establishment of synaptic vesicle localizationGO:009748010.018
phosphate containing compound metabolic processGO:00067961080.018
nuclear importGO:005117030.018
regulation of dendrite developmentGO:005077330.017
response to uvGO:000941130.017
stem cell proliferationGO:007208940.017
regulation of stem cell proliferationGO:007209120.017
organelle assemblyGO:00709251100.017
skeletal system developmentGO:00015011810.017
positive regulation of cellular metabolic processGO:0031325940.017
regulation of cellular ketone metabolic processGO:001056570.017
negative regulation of protein kinase activityGO:000646940.017
muscle cell differentiationGO:00426921390.017
regulation of ion transmembrane transporter activityGO:003241220.017
exocytosisGO:000688710.017
carbohydrate homeostasisGO:003350010.017
cellular amino acid metabolic processGO:000652070.017
internal peptidyl lysine acetylationGO:001839320.017
adherens junction organizationGO:003433240.017
cellular macromolecule biosynthetic processGO:00346452240.017
regulation of cellular amine metabolic processGO:003323800.017
microtubule organizing center organizationGO:003102310.017
single organism organelle organizationGO:19025891990.017
regulation of gtp catabolic processGO:003312420.017
cellular response to oxygen levelsGO:007145310.016
regulation of cellular amino acid metabolic processGO:000652100.016
intracellular signal transductionGO:0035556850.016
regulation of purine nucleotide catabolic processGO:003312120.016
lipid catabolic processGO:001604240.016
digestive tract morphogenesisGO:00485462310.016
response to alkaloidGO:004327920.016
negative regulation of defense responseGO:003134820.016
positive regulation of gtpase activityGO:004354710.016
response to nutrientGO:000758430.016
regulation of protein ubiquitinationGO:003139630.016
cell cycle g1 s phase transitionGO:004484310.016
meiotic cell cycle processGO:190304630.016
regulation of cellular protein catabolic processGO:190336210.016
glucose homeostasisGO:004259310.016
compound eye developmentGO:004874920.016
regulation of circadian rhythmGO:004275240.016
cell matrix adhesionGO:000716040.016
positive regulation of cytosolic calcium ion concentrationGO:000720440.016
positive regulation of i kappab kinase nf kappab signalingGO:004312330.016
negative regulation of epithelial cell proliferationGO:005068010.016
neuron developmentGO:00486662620.016
ribonucleoside monophosphate catabolic processGO:000915840.016
neurotransmitter secretionGO:000726920.016
regulation of macromolecule biosynthetic processGO:00105562250.015
purine nucleoside monophosphate catabolic processGO:000912840.015
lymphocyte proliferationGO:004665110.015
response to endogenous stimulusGO:0009719830.015
protein dephosphorylationGO:000647030.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
neurotransmitter transportGO:000683620.015
response to hexoseGO:000974630.015
negative regulation of protein transportGO:005122430.015
positive regulation of gene expressionGO:0010628710.015
regulation of cell deathGO:00109411030.015
single organism membrane fusionGO:004480120.015
regulation of reactive oxygen species metabolic processGO:200037720.015
regulation of dna replicationGO:000627530.015
system processGO:00030081850.015
membrane invaginationGO:001032410.015
protein acylationGO:004354330.015
positive regulation of nitrogen compound metabolic processGO:0051173690.015
positive regulation of nucleotide catabolic processGO:003081310.015
skeletal system morphogenesisGO:00487051020.015
transcription dna templatedGO:00063511810.015
segmentationGO:0035282970.015
nucleoside monophosphate catabolic processGO:000912540.015
secondary metabolic processGO:001974830.015
regulation of protein modification by small protein conjugation or removalGO:190332030.015
cellular response to organic substanceGO:00713101050.015
aromatic compound biosynthetic processGO:00194382170.015
antimicrobial humoral responseGO:001973020.015
organelle fusionGO:004828430.015
dorsal ventral pattern formationGO:00099531250.015
regulation of gtpase activityGO:004308720.014
rna localizationGO:000640340.014
regulation of multicellular organismal developmentGO:20000262230.014
stem cell divisionGO:001714510.014
sequestering of calcium ionGO:005120830.014
cellular carbohydrate metabolic processGO:004426240.014
regulation of apoptotic processGO:0042981980.014
double strand break repairGO:000630230.014
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.014
cellular localizationGO:0051641970.014
cell motilityGO:00488702440.014
positive regulation of nucleoside metabolic processGO:004597910.014
peptidyl serine modificationGO:001820920.014
cell morphogenesis involved in neuron differentiationGO:00486671630.014
phosphorus metabolic processGO:00067931090.014
response to corticosteroidGO:003196010.014
signal transduction in absence of ligandGO:003803410.014
b cell activationGO:004211320.014
apoptotic processGO:00069151160.014
vesicle localizationGO:0051648270.014
germ line stem cell divisionGO:004207810.014
transmembrane transportGO:00550851200.014
regulation of cell substrate adhesionGO:001081010.014
immune system developmentGO:00025201910.014
membrane fusionGO:006102520.014
response to glucoseGO:000974930.014
negative regulation of cell deathGO:0060548600.014
spermatid developmentGO:000728620.013
positive regulation of stem cell proliferationGO:200064810.013
positive regulation of erk1 and erk2 cascadeGO:007037420.013
regulation of stem cell differentiationGO:200073640.013
wnt signaling pathwayGO:0016055800.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
positive regulation of protein complex assemblyGO:003133420.013
transcription from rna polymerase ii promoterGO:0006366800.013
protein secretionGO:000930610.013
specification of symmetryGO:00097992040.013
regulation of organelle assemblyGO:190211540.013
cellular response to hypoxiaGO:007145610.013
adult behaviorGO:003053420.013
response to other organismGO:0051707970.013
regulation of developmental processGO:00507932470.013
development of primary female sexual characteristicsGO:004654540.013
mesenchyme developmentGO:00604851270.013
negative regulation of nitrogen compound metabolic processGO:0051172590.013
regulation of muscle contractionGO:000693730.013
positive regulation of synapse assemblyGO:005196510.013
protein localization to plasma membraneGO:007265910.013
sequestering of metal ionGO:005123830.013
negative regulation of intracellular transportGO:003238730.013
negative regulation of cell communicationGO:0010648960.013
cellular amide metabolic processGO:004360340.013
lipid homeostasisGO:005508830.013
small molecule catabolic processGO:004428230.013
regulation of biological qualityGO:00650082630.013
response to external biotic stimulusGO:0043207970.013
cellular component disassemblyGO:002241110.013
positive regulation of response to stimulusGO:0048584800.013
hormone secretionGO:004687920.013
spermatid differentiationGO:004851520.013
germ line stem cell maintenanceGO:003071820.013
regulation of rna biosynthetic processGO:20011412130.013
g1 s transition of mitotic cell cycleGO:000008210.013
negative regulation of metabolic processGO:0009892860.013
regulation of production of molecular mediator of immune responseGO:000270010.013
macromolecular complex subunit organizationGO:0043933740.012
regulation of cell shapeGO:000836010.012
cellular ketone metabolic processGO:0042180110.012
negative regulation of signalingGO:0023057960.012
cellular protein modification processGO:00064641000.012
neuroblast proliferationGO:000740520.012
cell projection morphogenesisGO:00488582440.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
retina development in camera type eyeGO:00600411460.012
regulation of tube sizeGO:003515020.012
negative regulation of programmed cell deathGO:0043069580.012
defense responseGO:0006952470.012
actin filament polymerizationGO:003004120.012
neuron projection developmentGO:00311751800.012
regulation of cell developmentGO:00602841000.012
protein polyubiquitinationGO:000020940.012
negative regulation of nucleocytoplasmic transportGO:004682320.012
response to glucocorticoidGO:005138410.012
negative regulation of immune responseGO:005077720.012
regulation of anatomical structure morphogenesisGO:00226031300.012
multi organism processGO:00517041340.012
negative regulation of catabolic processGO:000989530.012
determination of heart left right asymmetryGO:00613711170.012
regulation of mrna processingGO:005068430.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
calcium ion transport into cytosolGO:006040230.012
protein metabolic processGO:00195381830.012
sensory system developmentGO:0048880760.012
neurological system processGO:0050877620.012
negative regulation of intracellular protein transportGO:009031730.012
locomotionGO:00400113130.012
regulation of cell differentiationGO:00455951420.012
protein modification processGO:00362111000.012
protein homooligomerizationGO:005126030.012
embryo development ending in birth or egg hatchingGO:00097922710.012
muscle cell developmentGO:00550011150.012
ion transportGO:00068111140.012
regulation of response to stressGO:0080134360.012
regulation of dna templated transcription elongationGO:003278430.012
positive regulation of cell adhesionGO:004578510.012
regulation of extrinsic apoptotic signaling pathwayGO:200123630.012
negative regulation of signal transductionGO:0009968940.012
convergent extensionGO:00600261180.012
positive regulation of cytokine productionGO:000181920.012
monocyte differentiationGO:003022420.012
cytosolic calcium ion transportGO:006040130.012
negative regulation of nucleobase containing compound metabolic processGO:0045934590.012
mitotic dna integrity checkpointGO:004477440.012
positive regulation of muscle tissue developmentGO:190186310.011
cell migrationGO:00164772370.011
regulation of mesenchymal cell proliferationGO:001046410.011
negative regulation of macromolecule metabolic processGO:0010605760.011
centrosome cycleGO:000709810.011
regulation of neurotransmitter transportGO:005158810.011
viral processGO:001603210.011
dna templated transcription elongationGO:000635430.011
regulation of meiotic cell cycleGO:005144510.011
neuron projection morphogenesisGO:00488121610.011
cellular response to light stimulusGO:007148240.011
production of molecular mediator of immune responseGO:000244020.011
translational initiationGO:000641330.011
negative regulation of cellular biosynthetic processGO:0031327550.011
regulation of organ growthGO:004662030.011
regulation of nervous system developmentGO:0051960900.011
actin polymerization or depolymerizationGO:000815420.011
tube closureGO:006060610.011
positive regulation of apoptotic signaling pathwayGO:200123510.011
positive regulation of cellular amine metabolic processGO:003324000.011
canonical wnt signaling pathwayGO:0060070480.011
regulation of alternative mrna splicing via spliceosomeGO:000038110.011
negative regulation of cellular catabolic processGO:003133030.011
negative regulation of cellular metabolic processGO:0031324770.011
post embryonic organ developmentGO:004856940.011
heart morphogenesisGO:00030071560.011
endosomal transportGO:001619720.011
cell proliferationGO:0008283800.011
regulation of erk1 and erk2 cascadeGO:007037240.011
macromolecule modificationGO:00434121110.011
convergent extension involved in gastrulationGO:0060027710.011
establishment of localization in cellGO:0051649770.011
positive regulation of translationGO:004572710.011
peptidyl threonine phosphorylationGO:001810710.011
cellular response to molecule of bacterial originGO:007121930.011
regulation of peptidyl tyrosine phosphorylationGO:005073010.011
erk1 and erk2 cascadeGO:007037140.011
negative regulation of mapk cascadeGO:004340940.011
negative regulation of gene expressionGO:0010629650.011
camera type eye developmentGO:00430102220.011
positive regulation of neuron apoptotic processGO:004352510.011
localization of cellGO:00516742440.011
negative regulation of cytoplasmic transportGO:190365020.011
odontogenesis of dentin containing toothGO:004247510.011
peptide metabolic processGO:000651810.011
positive regulation of neuron deathGO:190121610.011
establishment of vesicle localizationGO:0051650240.011
positive regulation of gtp catabolic processGO:003312610.011
regulation of receptor activityGO:001046920.011
chemosensory behaviorGO:000763510.011
neuromuscular synaptic transmissionGO:000727420.011
response to oxygen levelsGO:0070482250.011
startle responseGO:000196440.011
negative regulation of mitosisGO:004583930.011
negative regulation of protein serine threonine kinase activityGO:007190120.011
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.011
multi organism reproductive processGO:0044703360.010
mitotic dna damage checkpointGO:004477340.010
response to ketoneGO:190165410.010
organic acid catabolic processGO:001605430.010
sleepGO:003043110.010
macromolecular complex assemblyGO:0065003350.010
cellular respirationGO:004533330.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.010
regulation of transcription from rna polymerase ii promoterGO:00063571140.010
positive regulation of purine nucleotide catabolic processGO:003312310.010
epithelial tube morphogenesisGO:00605621480.010
regulation of neurotransmitter secretionGO:004692810.010
negative regulation of cytokine productionGO:000181810.010
regulation of neuronal synaptic plasticityGO:004816810.010
negative regulation of protein complex assemblyGO:003133310.010
regulation of response to biotic stimulusGO:000283120.010
renal system developmentGO:0072001940.010
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.010
carboxylic acid catabolic processGO:004639530.010

crbn disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.060
nervous system diseaseDOID:86300.028
musculoskeletal system diseaseDOID:1700.018
disease of cellular proliferationDOID:1456600.014
disease of metabolismDOID:001466700.014
intrinsic cardiomyopathyDOID:006003600.013
cardiomyopathyDOID:005070000.013
muscle tissue diseaseDOID:6600.013
muscular diseaseDOID:008000000.013
heart diseaseDOID:11400.013
myopathyDOID:42300.013
cardiovascular system diseaseDOID:128700.013
inherited metabolic disorderDOID:65500.013
cancerDOID:16200.013
organ system cancerDOID:005068600.012