Danio rerio

39 known processes

melk

maternal embryonic leucine zipper kinase

(Aliases: fb71b01,wu:fb71b01,wu:fe01f04,fe01f04)

melk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.801
Worm
negative regulation of mitosisGO:004583930.701
meiotic nuclear divisionGO:000712640.456
organelle fissionGO:0048285230.391
cellular aromatic compound metabolic processGO:00067252950.335
stem cell proliferationGO:007208940.319
Worm
regulation of multicellular organismal processGO:00512392770.259
determination of bilateral symmetryGO:00098552040.256
heterocycle metabolic processGO:00464832900.244
regulation of nucleobase containing compound metabolic processGO:00192192500.243
nucleobase containing compound metabolic processGO:00061392740.239
regulation of protein catabolic processGO:004217610.239
embryo development ending in birth or egg hatchingGO:00097922710.237
vasculature developmentGO:00019442780.226
regulation of primary metabolic processGO:00800903110.225
organelle organizationGO:00069962270.218
cellular nitrogen compound metabolic processGO:00346412900.216
regulation of nitrogen compound metabolic processGO:00511712510.211
regulation of biological qualityGO:00650082630.210
aromatic compound biosynthetic processGO:00194382170.206
regulation of cellular metabolic processGO:00313233200.205
programmed cell deathGO:00125011190.197
Human Mouse Worm
positive regulation of cell cycleGO:004578730.191
meiotic cell cycle processGO:190304630.188
muscle structure developmentGO:00610611960.187
nuclear divisionGO:0000280230.186
maintenance of locationGO:005123540.166
cell deathGO:00082191210.159
Human Mouse Worm
blood vessel developmentGO:00015682460.158
nitrogen compound metabolic processGO:00068073190.157
cellular component movementGO:00069283350.155
apoptotic processGO:00069151160.155
Human Mouse Worm
modification dependent protein catabolic processGO:001994130.149
cell migrationGO:00164772370.149
cytoskeleton organizationGO:0007010960.148
biosynthetic processGO:00090582940.145
sister chromatid segregationGO:000081960.138
blood vessel morphogenesisGO:00485142160.138
meiotic chromosome segregationGO:004513230.137
cell projection organizationGO:00300302840.137
immune system developmentGO:00025201910.131
regulation of gene expressionGO:00104682650.126
chromosome organizationGO:0051276310.126
heterocycle biosynthetic processGO:00181302150.116
organic cyclic compound metabolic processGO:19013603010.114
negative regulation of nuclear divisionGO:005178430.113
generation of neuronsGO:00486993850.112
Worm
signal transductionGO:00071654550.112
Mouse
rna biosynthetic processGO:00327741810.108
regulation of multicellular organism growthGO:004001440.104
regulation of programmed cell deathGO:00430671010.102
Mouse
nucleic acid metabolic processGO:00903042440.102
immune system processGO:00023762410.099
cellular response to chemical stimulusGO:00708871570.097
Mouse
regulation of mitosisGO:000708890.097
single organism organelle organizationGO:19025891990.096
microtubule cytoskeleton organization involved in mitosisGO:190285010.095
cellular component assemblyGO:00226071700.094
Worm
spindle assembly involved in mitosisGO:009030710.092
nucleobase containing compound biosynthetic processGO:00346542050.091
cell cycle processGO:0022402530.088
cellular macromolecule metabolic processGO:00442603910.087
Human Mouse
positive regulation of biological processGO:00485182530.086
Mouse
single organism metabolic processGO:00447102170.086
regulation of macromolecule metabolic processGO:00602553170.085
proteolysis involved in cellular protein catabolic processGO:005160330.084
neuron differentiationGO:00301823530.084
chromosome segregationGO:0007059120.082
stem cell maintenanceGO:001982740.081
hematopoietic or lymphoid organ developmentGO:00485341910.080
regulation of apoptotic processGO:0042981980.077
Mouse
chordate embryonic developmentGO:00430092710.077
stem cell differentiationGO:00488631170.076
regulation of chromosome segregationGO:005198310.075
cell proliferationGO:0008283800.075
Human Mouse Worm
mitotic sister chromatid segregationGO:000007060.074
cellular biosynthetic processGO:00442492860.073
female meiotic divisionGO:000714320.073
oocyte maturationGO:000155640.072
deathGO:00162651210.071
Human Mouse Worm
negative regulation of cell divisionGO:005178240.071
cell motilityGO:00488702440.068
specification of symmetryGO:00097992040.068
angiogenesisGO:00015251580.068
cell fate commitmentGO:0045165990.065
Worm
positive regulation of purine nucleotide catabolic processGO:003312310.064
muscle organ developmentGO:00075171010.064
gene expressionGO:00104672520.064
regulation of protein metabolic processGO:0051246560.063
positive regulation of catabolic processGO:000989640.062
regulation of cellular component organizationGO:0051128860.061
protein targeting to nucleusGO:004474430.061
modification dependent macromolecule catabolic processGO:004363230.061
spindle assemblyGO:005122520.059
cytoskeleton dependent cytokinesisGO:006164030.059
behaviorGO:0007610740.059
small molecule metabolic processGO:0044281770.057
regulation of meiotic cell cycleGO:005144510.057
peptidyl serine phosphorylationGO:001810510.057
regulation of cell developmentGO:00602841000.056
regulation of metabolic processGO:00192223590.056
single organism nuclear importGO:190259330.055
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.055
positive regulation of cellular catabolic processGO:003133130.054
establishment of localizationGO:00512342440.052
regulation of transcription dna templatedGO:00063552130.051
cellular nitrogen compound biosynthetic processGO:00442712180.051
localization of cellGO:00516742440.051
negative regulation of cell cycle processGO:001094890.050
mitotic nuclear divisionGO:0007067180.050
cellular response to endogenous stimulusGO:0071495680.050
male meiosisGO:000714020.050
regulation of heart growthGO:006042020.050
negative regulation of catabolic processGO:000989530.049
establishment of protein localization to organelleGO:007259440.049
cell divisionGO:0051301200.048
Worm
regulation of rna metabolic processGO:00512522240.048
protein processingGO:0016485120.048
regulation of nucleoside metabolic processGO:000911820.047
camera type eye developmentGO:00430102220.047
cell cycleGO:0007049930.047
positive regulation of nitrogen compound metabolic processGO:0051173690.047
single organism localizationGO:19025782250.046
neuron projection developmentGO:00311751800.046
regulation of response to stimulusGO:00485832690.045
determination of left right symmetryGO:00073681790.045
multi organism processGO:00517041340.045
regulation of nucleic acid templated transcriptionGO:19035062130.045
regulation of signal transductionGO:00099662250.044
head developmentGO:00603223030.044
striated muscle tissue developmentGO:00147061100.044
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.044
somatic muscle developmentGO:000752540.043
regulation of developmental processGO:00507932470.043
negative regulation of cellular processGO:00485232830.043
cell surface receptor signaling pathwayGO:00071663250.043
central nervous system developmentGO:00074173870.042
cellular response to organic substanceGO:00713101050.042
positive regulation of chromosome organizationGO:200125210.042
muscle cell differentiationGO:00426921390.042
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.041
regulation of neurogenesisGO:0050767870.040
nuclear importGO:005117030.040
neuron developmentGO:00486662620.040
neuroblast proliferationGO:000740520.040
Worm
regulation of cell cycleGO:0051726520.039
cellular protein catabolic processGO:004425740.039
regulation of rna biosynthetic processGO:20011412130.039
single organism transportGO:00447652060.039
negative regulation of apoptotic processGO:0043066550.038
cellular component morphogenesisGO:00329893360.038
locomotionGO:00400113130.038
muscle cell developmentGO:00550011150.038
regulation of bindingGO:005109830.037
negative regulation of chromosome organizationGO:200125110.037
multicellular organism growthGO:003526440.036
mitotic metaphase plate congressionGO:000708010.036
regulation of nuclear divisionGO:005178390.036
response to stressGO:00069502630.036
Mouse
positive regulation of cellular metabolic processGO:0031325940.036
regulation of microtubule cytoskeleton organizationGO:007050730.035
organic substance biosynthetic processGO:19015762890.035
ubiquitin dependent protein catabolic processGO:000651130.035
organonitrogen compound metabolic processGO:1901564740.035
guanosine containing compound metabolic processGO:190106840.034
agingGO:000756820.034
positive regulation of metabolic processGO:00098931080.034
cellular macromolecule biosynthetic processGO:00346452240.034
regulation of purine nucleotide catabolic processGO:003312120.033
neural retina developmentGO:0003407490.033
regulation of cellular biosynthetic processGO:00313262450.033
regulation of cell divisionGO:0051302120.033
regulation of cellular protein metabolic processGO:0032268520.033
guanosine containing compound catabolic processGO:190106920.033
regulation of signalingGO:00230512350.032
regulation of cellular macromolecule biosynthetic processGO:20001122220.032
protein localization to nucleusGO:003450430.031
cell morphogenesisGO:00009022890.031
cell morphogenesis involved in differentiationGO:00009041950.031
pancreas developmentGO:0031016840.031
chromosome organization involved in meiosisGO:007019210.031
regulation of cell deathGO:00109411030.030
Mouse
organic cyclic compound biosynthetic processGO:19013622230.030
developmental process involved in reproductionGO:0003006270.030
cell proliferation in forebrainGO:002184630.030
negative regulation of cellular catabolic processGO:003133030.030
developmental growthGO:00485891660.030
positive regulation of multicellular organismal processGO:0051240520.029
regulation of cell communicationGO:00106462320.029
cellular protein metabolic processGO:00442671290.028
Human Mouse
regulation of biosynthetic processGO:00098892500.028
macromolecule biosynthetic processGO:00090592270.028
single organism reproductive processGO:0044702400.028
peptidyl serine modificationGO:001820920.027
regulation of organelle assemblyGO:190211540.027
response to biotic stimulusGO:0009607970.027
negative regulation of metabolic processGO:0009892860.027
brain developmentGO:00074202930.027
sensory organ developmentGO:00074233930.027
negative regulation of cytoplasmic transportGO:190365020.026
negative regulation of protein localization to nucleusGO:190018120.026
positive regulation of nucleoside metabolic processGO:004597910.026
positive regulation of cell divisionGO:005178120.026
ribonucleoside monophosphate catabolic processGO:000915840.026
dorsal ventral pattern formationGO:00099531250.026
embryonic organ developmentGO:00485683810.026
stem cell developmentGO:0048864820.026
regulation of macromolecule biosynthetic processGO:00105562250.026
microtubule based processGO:0007017600.026
regulation of nucleotide catabolic processGO:003081120.025
gland developmentGO:00487321430.025
meiosis iGO:000712710.025
cytokinetic processGO:003250620.025
chromosome localizationGO:005000020.025
regulation of protein ubiquitinationGO:003139630.025
positive regulation of macromolecule metabolic processGO:0010604930.025
cellular protein modification processGO:00064641000.025
Human Mouse
proteasomal protein catabolic processGO:001049820.025
pharyngeal system developmentGO:0060037180.025
female meiosis chromosome segregationGO:001632110.024
negative regulation of gene expressionGO:0010629650.024
negative regulation of mitotic cell cycleGO:0045930110.023
negative regulation of multicellular organismal processGO:0051241690.023
rna metabolic processGO:00160702190.023
transcription dna templatedGO:00063511810.023
zymogen activationGO:003163830.023
regulation of nervous system developmentGO:0051960900.023
regulation of organelle organizationGO:0033043290.023
response to woundingGO:00096111160.022
macromolecule modificationGO:00434121110.022
Human Mouse
protein complex disassemblyGO:004324110.022
neural precursor cell proliferationGO:0061351200.022
Mouse Worm
growthGO:00400071740.021
cellular component disassemblyGO:002241110.021
organelle assemblyGO:00709251100.021
positive regulation of cellular processGO:00485222010.021
Mouse
somitogenesisGO:0001756870.021
fertilizationGO:000956630.021
homologous chromosome segregationGO:004514310.021
negative regulation of protein kinase activityGO:000646940.021
digestive tract developmentGO:00485652650.021
actomyosin structure organizationGO:0031032530.021
myofibril assemblyGO:0030239480.021
morphogenesis of an epitheliumGO:00020093330.020
heart developmentGO:00075073130.020
phosphorus metabolic processGO:00067931090.020
Human Mouse
regulation of gtp catabolic processGO:003312420.020
negative regulation of programmed cell deathGO:0043069580.020
microtubule depolymerizationGO:000701910.020
regulation of reproductive processGO:200024140.020
regulation of catalytic activityGO:0050790550.020
regulation of stem cell proliferationGO:007209120.020
protein importGO:001703830.020
dna metabolic processGO:0006259270.020
striated muscle cell developmentGO:00550021080.020
microtubule organizing center organizationGO:003102310.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
heart processGO:0003015710.020
response to other organismGO:0051707970.019
negative regulation of cell deathGO:0060548600.019
cellular ketone metabolic processGO:0042180110.019
positive regulation of developmental processGO:0051094500.019
regulation of protein targetingGO:190353320.019
negative regulation of macromolecule metabolic processGO:0010605760.019
protein import into nucleusGO:000660630.019
enzyme linked receptor protein signaling pathwayGO:00071671060.019
regulation of protein import into nucleusGO:004230620.019
regulation of cell differentiationGO:00455951420.019
positive regulation of nucleotide catabolic processGO:003081310.018
reciprocal dna recombinationGO:003582510.018
positive regulation of stem cell proliferationGO:200064810.018
negative regulation of cell cycleGO:0045786140.018
negative regulation of cellular metabolic processGO:0031324770.018
muscle tissue developmentGO:00605371100.018
macromolecular complex disassemblyGO:003298410.018
response to corticosteroidGO:003196010.018
neural tube patterningGO:0021532330.018
striated muscle cell differentiationGO:00511461290.018
digestive system developmentGO:00551232890.018
single fertilizationGO:000733830.018
amine metabolic processGO:000930820.018
mitotic cytokinesisGO:000028130.018
microtubule cytoskeleton organizationGO:0000226330.018
humoral immune response mediated by circulating immunoglobulinGO:000245530.017
cytokinesisGO:000091030.017
gtp catabolic processGO:000618420.017
mitotic dna integrity checkpointGO:004477440.017
regulation of mitotic cell cycleGO:0007346250.017
response to chemicalGO:00422213200.017
Mouse
regulation of protein modification by small protein conjugation or removalGO:190332030.017
response to ketoneGO:190165410.017
response to endogenous stimulusGO:0009719830.017
regulation of cardiac muscle tissue developmentGO:005502410.017
anterior posterior pattern specificationGO:00099521520.016
regulation of cell cycle processGO:0010564200.016
regulation of molecular functionGO:0065009700.016
macromolecule localizationGO:0033036540.016
regulation of phosphate metabolic processGO:0019220430.016
cellular component assembly involved in morphogenesisGO:00109271070.016
hepaticobiliary system developmentGO:0061008980.016
protein phosphorylationGO:0006468470.016
Human Mouse
organelle fusionGO:004828430.016
organic acid metabolic processGO:0006082310.016
carboxylic acid metabolic processGO:0019752220.016
cellular component biogenesisGO:00440851780.016
Worm
retina development in camera type eyeGO:00600411460.015
negative regulation of protein phosphorylationGO:000193340.015
regulation of cellular protein catabolic processGO:190336210.015
digestive tract morphogenesisGO:00485462310.015
macromolecular complex subunit organizationGO:0043933740.015
positive regulation of cell differentiationGO:0045597300.015
meiotic cell cycleGO:005132150.015
purine nucleotide metabolic processGO:0006163270.015
regulation of growthGO:0040008420.015
regulation of organ growthGO:004662030.014
positive regulation of muscle organ developmentGO:004863610.014
regulation of cell proliferationGO:0042127370.014
nucleocytoplasmic transportGO:000691340.014
mitotic cell cycleGO:0000278640.014
negative regulation of cell cycle phase transitionGO:190198850.014
embryonic heart tube morphogenesisGO:00031431080.014
protein homooligomerizationGO:005126030.014
regenerationGO:0031099910.014
positive regulation of nervous system developmentGO:0051962250.013
regionalizationGO:00030022740.013
axon developmentGO:00615641660.013
negative regulation of developmental processGO:0051093650.013
microtubule polymerization or depolymerizationGO:003110930.013
reproductive system developmentGO:006145850.013
regulation of dendrite developmentGO:005077330.013
negative regulation of signal transductionGO:0009968940.013
negative regulation of intracellular transportGO:003238730.013
intrinsic apoptotic signaling pathwayGO:0097193200.013
Mouse
response to lipidGO:0033993600.013
nucleobase containing small molecule metabolic processGO:0055086320.013
oxoacid metabolic processGO:0043436310.013
camera type eye morphogenesisGO:00485931080.013
urogenital system developmentGO:0001655970.013
vesicle mediated transportGO:0016192220.012
regulation of nucleocytoplasmic transportGO:004682220.012
symbiosis encompassing mutualism through parasitismGO:004440340.012
wound healingGO:0042060900.012
nuclear transportGO:005116940.012
germ line stem cell maintenanceGO:003071820.012
cell projection morphogenesisGO:00488582440.012
regulation of neuron differentiationGO:0045664560.012
ameboidal type cell migrationGO:00016671430.012
multicellular organismal reproductive processGO:0048609350.012
regulation of phosphorus metabolic processGO:0051174430.012
negative regulation of protein maturationGO:1903318100.012
positive regulation of neurogenesisGO:0050769240.012
regulation of gtpase activityGO:004308720.012
reproductionGO:0000003400.012
regulation of protein localization to nucleusGO:190018020.012
nucleic acid templated transcriptionGO:00976591810.012
lymphocyte proliferationGO:004665110.012
positive regulation of cellular amine metabolic processGO:003324000.012
eye developmentGO:00016542770.012
retina morphogenesis in camera type eyeGO:0060042790.012
transportGO:00068102200.012
reproductive processGO:0022414400.012
protein modification processGO:00362111000.011
Human Mouse
negative regulation of cellular protein metabolic processGO:0032269160.011
response to organic cyclic compoundGO:0014070510.011
positive regulation of transportGO:005105020.011
otic vesicle formationGO:0030916270.011
cardiocyte differentiationGO:0035051440.011
multicellular organism reproductionGO:0032504350.011
protein polyubiquitinationGO:000020940.011
gastrulationGO:00073692080.011
negative regulation of nucleocytoplasmic transportGO:004682320.011
macromolecular complex assemblyGO:0065003350.011
neural crest cell migrationGO:0001755420.011
negative regulation of macromolecule biosynthetic processGO:0010558480.011
protein metabolic processGO:00195381830.011
Human Mouse
ribonucleoside metabolic processGO:0009119110.011
sensory organ morphogenesisGO:00905962000.011
regulation of cytokine productionGO:000181730.011
positive regulation of nucleobase containing compound metabolic processGO:0045935690.011
homeostatic processGO:00425921420.011
response to external biotic stimulusGO:0043207970.011
protein localizationGO:0008104400.011
organelle localizationGO:0051640490.011
embryonic cranial skeleton morphogenesisGO:0048701900.011
lipid storageGO:001991510.011
positive regulation of multi organism processGO:004390230.011
response to external stimulusGO:00096052640.011
regulation of mrna processingGO:005068430.011
stem cell fate commitmentGO:004886510.011
establishment of localization in cellGO:0051649770.010
positive regulation of phosphorus metabolic processGO:0010562210.010
intracellular signal transductionGO:0035556850.010
Mouse
cell cycle g2 m phase transitionGO:004483940.010
cell migration involved in gastrulationGO:0042074790.010
liver developmentGO:0001889960.010
positive regulation of reproductive processGO:200024320.010
regulation of cellular ketone metabolic processGO:001056570.010
response to drugGO:004249330.010
proteolysisGO:0006508380.010
negative regulation of response to stimulusGO:00485851040.010
determination of heart left right asymmetryGO:00613711170.010
meiosis iiGO:000713510.010
dna biosynthetic processGO:007189730.010
gliogenesisGO:0042063450.010

melk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.028
cancerDOID:16200.028
organ system cancerDOID:005068600.025
disease of anatomical entityDOID:700.023
gastrointestinal system cancerDOID:311900.019
colorectal cancerDOID:925600.015
intestinal cancerDOID:1015500.015
large intestine cancerDOID:567200.015
colon cancerDOID:21900.013
colon carcinomaDOID:152000.013
nervous system diseaseDOID:86300.012