IMP: Integrative Multi-species Prediction

Danio rerio

54 known processes

cdx1a

caudal type homeo box transcription factor 1 a

(Aliases: cdx2)

Ensembl: ENSDARG00000087811
Entrez: 405762
ZFIN: ZDB-GENE-050510-1
UniProtKB: Q8AXR4

Process Predictions
Disease Predictions

cdx1a biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability
central nervous system development	GO:0007417	387	0.669
brain development	GO:0007420	293	0.659
head development	GO:0060322	303	0.422
biosynthetic process	GO:0009058	294	0.364
sensory organ development	GO:0007423	393	0.353
regulation of cellular biosynthetic process	GO:0031326	245	0.352
negative regulation of biological process	GO:0048519	304	0.328
regulation of multicellular organismal development	GO:2000026	223	0.299
hormone transport	GO:0009914	2	0.299
transcription from rna polymerase ii promoter	GO:0006366	80	0.290
regulation of nitrogen compound metabolic process	GO:0051171	251	0.272
lipid storage	GO:0019915	1	0.270
cellular biosynthetic process	GO:0044249	286	0.268
heart development	GO:0007507	313	0.260
localization of cell	GO:0051674	244	0.254
generation of neurons	GO:0048699	385	0.252
tube morphogenesis	GO:0035239	349	0.239
positive regulation of cell fate commitment	GO:0010455	1	0.237
regionalization	GO:0003002	274	0.220
organic substance biosynthetic process	GO:1901576	289	0.219
blood vessel development	GO:0001568	246	0.211
negative regulation of cellular process	GO:0048523	283	0.209
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.181
aromatic compound biosynthetic process	GO:0019438	217	0.170
foregut morphogenesis	GO:0007440	4	0.168
heart looping	GO:0001947	94	0.155
hormone secretion	GO:0046879	2	0.154
eye development	GO:0001654	277	0.150
regulation of gene expression	GO:0010468	265	0.144
embryonic foregut morphogenesis	GO:0048617	1	0.144
vasculature development	GO:0001944	278	0.143
response to stress	GO:0006950	263	0.140
determination of left right symmetry	GO:0007368	179	0.139
digestive system development	GO:0055123	289	0.138
gene expression	GO:0010467	252	0.135
neuron development	GO:0048666	262	0.132
embryo development ending in birth or egg hatching	GO:0009792	271	0.129
locomotion	GO:0040011	313	0.127
cellular amine metabolic process	GO:0044106	2	0.126
adult behavior	GO:0030534	2	0.126
morphogenesis of an epithelium	GO:0002009	333	0.126
cell differentiation in spinal cord	GO:0021515	40	0.125
regulation of response to stimulus	GO:0048583	269	0.120
signal transduction	GO:0007165	455	0.120
cell motility	GO:0048870	244	0.111
cellular aromatic compound metabolic process	GO:0006725	295	0.108
cell surface receptor signaling pathway	GO:0007166	325	0.107
nucleobase containing compound metabolic process	GO:0006139	274	0.106
nucleic acid templated transcription	GO:0097659	181	0.106
regulation of hormone secretion	GO:0046883	2	0.103
regulation of biosynthetic process	GO:0009889	250	0.099
regulation of rna biosynthetic process	GO:2001141	213	0.099
retina development in camera type eye	GO:0060041	146	0.098
appendage development	GO:0048736	80	0.097
response to external stimulus	GO:0009605	264	0.097
rna biosynthetic process	GO:0032774	181	0.095
embryonic organ development	GO:0048568	381	0.095
regulation of biological quality	GO:0065008	263	0.094
maintenance of location	GO:0051235	4	0.091
heterocycle biosynthetic process	GO:0018130	215	0.091
regulation of rna metabolic process	GO:0051252	224	0.091
regulation of macromolecule biosynthetic process	GO:0010556	225	0.090
determination of bilateral symmetry	GO:0009855	204	0.090
regulation of cellular metabolic process	GO:0031323	320	0.089
nucleobase containing compound biosynthetic process	GO:0034654	205	0.089
digestive tract development	GO:0048565	265	0.088
aging	GO:0007568	2	0.088
pancreas development	GO:0031016	84	0.087
regulation of primary metabolic process	GO:0080090	311	0.084
negative regulation of rna biosynthetic process	GO:1902679	45	0.083
embryonic organ morphogenesis	GO:0048562	274	0.083
cellular component biogenesis	GO:0044085	178	0.081
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.080
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.079
sensory organ morphogenesis	GO:0090596	200	0.078
regulation of macromolecule metabolic process	GO:0060255	317	0.077
regulation of metabolic process	GO:0019222	359	0.075
eye morphogenesis	GO:0048592	144	0.074
regulation of neural precursor cell proliferation	GO:2000177	3	0.073
embryonic heart tube development	GO:0035050	133	0.070
lipid biosynthetic process	GO:0008610	22	0.069
centrosome organization	GO:0051297	1	0.068
negative regulation of transcription dna templated	GO:0045892	45	0.068
heterocycle metabolic process	GO:0046483	290	0.068
carboxylic acid metabolic process	GO:0019752	22	0.067
regulation of multicellular organismal process	GO:0051239	277	0.066
chordate embryonic development	GO:0043009	271	0.066
cell fate specification	GO:0001708	68	0.065
organic cyclic compound biosynthetic process	GO:1901362	223	0.064
peptide transport	GO:0015833	1	0.062
larval development	GO:0002164	2	0.062
cell fate commitment	GO:0045165	99	0.061
positive regulation of cellular process	GO:0048522	201	0.061
regulation of transcription dna templated	GO:0006355	213	0.059
forebrain development	GO:0030900	96	0.059
bmp signaling pathway	GO:0030509	52	0.058
mesenchyme development	GO:0060485	127	0.058
determination of heart left right asymmetry	GO:0061371	117	0.058
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.058
positive regulation of cellular component biogenesis	GO:0044089	3	0.056
specification of symmetry	GO:0009799	204	0.056
epithelial cell differentiation	GO:0030855	116	0.056
regulation of developmental process	GO:0050793	247	0.056
regulation of nucleic acid templated transcription	GO:1903506	213	0.055
organic cyclic compound metabolic process	GO:1901360	301	0.055
cellular component movement	GO:0006928	335	0.055
somitogenesis	GO:0001756	87	0.053
blood vessel morphogenesis	GO:0048514	216	0.053
regulation of cellular amine metabolic process	GO:0033238	0	0.053
transcription dna templated	GO:0006351	181	0.053
fin development	GO:0033333	77	0.052
digestive tract morphogenesis	GO:0048546	231	0.052
immune system process	GO:0002376	241	0.051
cellular nitrogen compound metabolic process	GO:0034641	290	0.051
neural retina development	GO:0003407	49	0.051
pectoral fin development	GO:0033339	50	0.050
amine metabolic process	GO:0009308	2	0.050
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.049
embryonic heart tube morphogenesis	GO:0003143	108	0.048
immune system development	GO:0002520	191	0.047
retina layer formation	GO:0010842	24	0.046
neuroblast proliferation	GO:0007405	2	0.045
regulation of cell communication	GO:0010646	232	0.045
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.044
somite development	GO:0061053	96	0.044
regulation of gastrulation	GO:0010470	24	0.044
regulation of signal transduction	GO:0009966	225	0.044
renal system development	GO:0072001	94	0.044
thioester metabolic process	GO:0035383	1	0.043
post embryonic morphogenesis	GO:0009886	4	0.043
endocrine system development	GO:0035270	65	0.043
response to nutrient	GO:0007584	3	0.042
ventral spinal cord development	GO:0021517	35	0.042
regulation of stem cell differentiation	GO:2000736	4	0.042
homeostatic process	GO:0042592	142	0.040
macromolecule biosynthetic process	GO:0009059	227	0.040
cell proliferation in hindbrain	GO:0021534	4	0.040
axis specification	GO:0009798	43	0.040
neural tube patterning	GO:0021532	33	0.040
negative regulation of rna metabolic process	GO:0051253	48	0.039
camera type eye development	GO:0043010	222	0.039
retina morphogenesis in camera type eye	GO:0060042	79	0.039
rna metabolic process	GO:0016070	219	0.039
cell projection organization	GO:0030030	284	0.038
protein localization to nucleus	GO:0034504	3	0.038
gastrulation	GO:0007369	208	0.038
regulation of localization	GO:0032879	104	0.037
negative regulation of endodermal cell fate specification	GO:0042664	8	0.036
kidney development	GO:0001822	92	0.036
positive regulation of stem cell proliferation	GO:2000648	1	0.036
cellular macromolecule biosynthetic process	GO:0034645	224	0.035
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.034
regulation of cell activation	GO:0050865	1	0.034
positive regulation of muscle tissue development	GO:1901863	1	0.034
endodermal cell fate commitment	GO:0001711	18	0.034
liver development	GO:0001889	96	0.034
regulation of stem cell proliferation	GO:0072091	2	0.034
oxoacid metabolic process	GO:0043436	31	0.033
response to monosaccharide	GO:0034284	3	0.033
protein metabolic process	GO:0019538	183	0.033
growth	GO:0040007	174	0.033
positive regulation of biological process	GO:0048518	253	0.033
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.033
peripheral nervous system neuron differentiation	GO:0048934	28	0.033
embryonic camera type eye development	GO:0031076	29	0.032
regulation of neuron migration	GO:2001222	2	0.032
negative regulation of gastrulation	GO:2000542	11	0.032
muscle tissue development	GO:0060537	110	0.032
compound eye development	GO:0048749	2	0.032
cardiac muscle cell differentiation	GO:0055007	30	0.031
skeletal system development	GO:0001501	181	0.031
aorta morphogenesis	GO:0035909	3	0.031
negative regulation of developmental process	GO:0051093	65	0.031
response to vitamin	GO:0033273	3	0.031
blood circulation	GO:0008015	87	0.031
dorsal ventral pattern formation	GO:0009953	125	0.031
ameboidal type cell migration	GO:0001667	143	0.030
skeletal muscle organ development	GO:0060538	78	0.030
regulation of reproductive process	GO:2000241	4	0.030
neuron differentiation	GO:0030182	353	0.030
multicellular organism growth	GO:0035264	4	0.030
response to drug	GO:0042493	3	0.030
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.030
positive regulation of response to stimulus	GO:0048584	80	0.029
small molecule metabolic process	GO:0044281	77	0.029
embryonic appendage morphogenesis	GO:0035113	30	0.029
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.029
floor plate morphogenesis	GO:0033505	12	0.028
positive regulation of protein complex assembly	GO:0031334	2	0.028
spinal cord oligodendrocyte cell fate specification	GO:0021530	2	0.028
mechanoreceptor differentiation	GO:0042490	37	0.028
macromolecule modification	GO:0043412	111	0.028
regulation of multicellular organism growth	GO:0040014	4	0.028
organic acid metabolic process	GO:0006082	31	0.027
transcription from rna polymerase iii promoter	GO:0006383	1	0.027
negative regulation of wnt signaling pathway involved in heart development	GO:0003308	2	0.027
endoderm development	GO:0007492	49	0.027
anterior posterior pattern specification	GO:0009952	152	0.026
fin morphogenesis	GO:0033334	53	0.026
epidermis development	GO:0008544	48	0.026
hematopoietic or lymphoid organ development	GO:0048534	191	0.025
endodermal digestive tract morphogenesis	GO:0061031	2	0.025
negative regulation of gene expression	GO:0010629	65	0.025
nucleic acid metabolic process	GO:0090304	244	0.025
regulation of transcription involved in cell fate commitment	GO:0060850	1	0.025
cardiac muscle tissue development	GO:0048738	48	0.025
kupffer s vesicle development	GO:0070121	50	0.025
response to vitamin b3	GO:0033552	2	0.025
appendage morphogenesis	GO:0035107	56	0.025
angiogenesis	GO:0001525	158	0.024
system process	GO:0003008	185	0.024
epithelial tube morphogenesis	GO:0060562	148	0.024
transport	GO:0006810	220	0.024
regulation of wnt signaling pathway	GO:0030111	53	0.024
epidermal cell fate specification	GO:0009957	4	0.024
cell projection morphogenesis	GO:0048858	244	0.024
regulation of cardiac muscle cell differentiation	GO:2000725	1	0.024
positive regulation of gene expression	GO:0010628	71	0.024
lipid metabolic process	GO:0006629	52	0.023
regulation of embryonic development	GO:0045995	47	0.023
ear development	GO:0043583	127	0.023
multi organism process	GO:0051704	134	0.023
regulation of cell development	GO:0060284	100	0.023
cellular lipid metabolic process	GO:0044255	36	0.023
gland development	GO:0048732	143	0.022
heart morphogenesis	GO:0003007	156	0.022
positive regulation of biosynthetic process	GO:0009891	68	0.022
regulation of endodermal cell fate specification	GO:0042663	15	0.022
hindbrain development	GO:0030902	91	0.022
developmental growth involved in morphogenesis	GO:0060560	86	0.022
skeletal muscle tissue development	GO:0007519	67	0.022
cardiocyte differentiation	GO:0035051	44	0.022
negative regulation of endodermal cell differentiation	GO:1903225	8	0.022
hepaticobiliary system development	GO:0061008	98	0.021
positive regulation of striated muscle tissue development	GO:0045844	1	0.021
positive regulation of cellular metabolic process	GO:0031325	94	0.021
forebrain regionalization	GO:0021871	4	0.021
oligodendrocyte cell fate specification	GO:0021778	4	0.021
cellular macromolecule metabolic process	GO:0044260	391	0.021
regulation of locomotion	GO:0040012	55	0.021
muscle fiber development	GO:0048747	52	0.021
cell migration	GO:0016477	237	0.021
epidermal cell differentiation	GO:0009913	36	0.021
cranial nerve development	GO:0021545	42	0.021
regulation of cell differentiation	GO:0045595	142	0.021
acyl coa metabolic process	GO:0006637	1	0.020
neuron projection development	GO:0031175	180	0.020
wnt signaling pathway	GO:0016055	80	0.020
striated muscle tissue development	GO:0014706	110	0.020
ear morphogenesis	GO:0042471	64	0.020
cellular response to decreased oxygen levels	GO:0036294	1	0.020
negative regulation of biosynthetic process	GO:0009890	55	0.020
inner ear development	GO:0048839	126	0.019
nitrogen compound metabolic process	GO:0006807	319	0.019
positive regulation of cell activation	GO:0050867	1	0.019
central nervous system neuron differentiation	GO:0021953	74	0.019
developmental pigmentation	GO:0048066	48	0.019
negative regulation of signal transduction	GO:0009968	94	0.019
neuron fate specification	GO:0048665	20	0.019
mesenchymal cell differentiation	GO:0048762	87	0.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.019
water homeostasis	GO:0030104	4	0.018
stem cell differentiation	GO:0048863	117	0.018
formation of primary germ layer	GO:0001704	62	0.018
macromolecule localization	GO:0033036	54	0.018
positive regulation of cell communication	GO:0010647	56	0.018
protein targeting to nucleus	GO:0044744	3	0.018
ectodermal placode development	GO:0071696	37	0.018
skin development	GO:0043588	54	0.018
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.018
adenohypophysis development	GO:0021984	15	0.018
post anal tail morphogenesis	GO:0036342	19	0.017
nucleocytoplasmic transport	GO:0006913	4	0.017
floor plate formation	GO:0021508	12	0.017
endoderm formation	GO:0001706	29	0.017
convergent extension	GO:0060026	118	0.017
regulation of ion transmembrane transporter activity	GO:0032412	2	0.017
stem cell proliferation	GO:0072089	4	0.017
type b pancreatic cell development	GO:0003323	4	0.017
centrosome cycle	GO:0007098	1	0.016
notochord development	GO:0030903	54	0.016
regulation of nodal signaling pathway	GO:1900107	4	0.016
cell part morphogenesis	GO:0032990	246	0.016
spindle assembly	GO:0051225	2	0.016
spinal cord motor neuron cell fate specification	GO:0021520	8	0.016
negative regulation of cellular biosynthetic process	GO:0031327	55	0.016
neural crest cell development	GO:0014032	62	0.016
negative regulation of muscle tissue development	GO:1901862	2	0.016
neural tube development	GO:0021915	62	0.016
negative regulation of stem cell differentiation	GO:2000737	2	0.016
chemotaxis	GO:0006935	104	0.016
positive regulation of transport	GO:0051050	2	0.016
cell morphogenesis	GO:0000902	289	0.016
embryonic digestive tract morphogenesis	GO:0048557	3	0.016
negative regulation of oocyte development	GO:0060283	2	0.015
photoreceptor cell fate commitment	GO:0046552	1	0.015
negative regulation of protein complex assembly	GO:0031333	1	0.015
eye photoreceptor cell differentiation	GO:0001754	45	0.015
ectodermal placode morphogenesis	GO:0071697	32	0.015
positive regulation of metabolic process	GO:0009893	108	0.015
positive regulation of cellular amine metabolic process	GO:0033240	0	0.015
somite specification	GO:0001757	12	0.015
positive regulation of embryonic development	GO:0040019	3	0.015
mesenchymal cell development	GO:0014031	78	0.015
single organism organelle organization	GO:1902589	199	0.015
response to organic substance	GO:0010033	153	0.015
organonitrogen compound metabolic process	GO:1901564	74	0.015
cellular ketone metabolic process	GO:0042180	11	0.015
amide biosynthetic process	GO:0043604	1	0.015
exocrine pancreas development	GO:0031017	28	0.015
regulation of anatomical structure morphogenesis	GO:0022603	130	0.015
response to glucose	GO:0009749	3	0.015
endodermal cell differentiation	GO:0035987	19	0.014
positive regulation of cellular biosynthetic process	GO:0031328	68	0.014
establishment of localization	GO:0051234	244	0.014
inner ear receptor cell fate commitment	GO:0060120	4	0.014
negative regulation of protein phosphorylation	GO:0001933	4	0.014
response to chemical	GO:0042221	320	0.014
non canonical wnt signaling pathway involved in heart development	GO:0061341	2	0.014
protein complex biogenesis	GO:0070271	30	0.014
organic substance transport	GO:0071702	58	0.014
cellular component assembly	GO:0022607	170	0.014
alcohol biosynthetic process	GO:0046165	2	0.014
positive regulation of secretion	GO:0051047	1	0.014
periodic partitioning	GO:0007365	1	0.014
otic vesicle development	GO:0071599	42	0.014
negative regulation of metabolic process	GO:0009892	86	0.013
regulation of mesodermal cell fate specification	GO:0042661	9	0.013
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.013
embryonic digestive tract development	GO:0048566	4	0.013
heart process	GO:0003015	71	0.013
peripheral nervous system development	GO:0007422	55	0.013
cellular amino acid metabolic process	GO:0006520	7	0.013
endocrine process	GO:0050886	2	0.013
common bile duct development	GO:0061009	13	0.013
single organism metabolic process	GO:0044710	217	0.013
cell proliferation	GO:0008283	80	0.013
eye photoreceptor cell development	GO:0042462	30	0.013
negative regulation of wnt signaling pathway	GO:0030178	30	0.013
production of molecular mediator of immune response	GO:0002440	2	0.013
protein import	GO:0017038	3	0.013
response to hexose	GO:0009746	3	0.013
negative regulation of gliogenesis	GO:0014014	1	0.013
cardiac conduction system development	GO:0003161	1	0.013
stem cell development	GO:0048864	82	0.013
positive regulation of striated muscle cell differentiation	GO:0051155	1	0.013
photoreceptor cell fate specification	GO:0043704	1	0.013
regulation of signaling	GO:0023051	235	0.013
regulation of angiogenesis	GO:0045765	26	0.012
glial cell differentiation	GO:0010001	42	0.012
lateral line development	GO:0048882	66	0.012
mesoderm morphogenesis	GO:0048332	51	0.012
muscle structure development	GO:0061061	196	0.012
pigmentation	GO:0043473	85	0.012
striated muscle cell differentiation	GO:0051146	129	0.012
cell proliferation in forebrain	GO:0021846	3	0.012
cellular component morphogenesis	GO:0032989	336	0.012
single organism nuclear import	GO:1902593	3	0.012
regulation of transcription from rna polymerase iii promoter	GO:0006359	1	0.012
neural crest cell differentiation	GO:0014033	72	0.012
positive regulation of neuron migration	GO:2001224	2	0.012
skeletal muscle fiber development	GO:0048741	35	0.012
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.012
cellular protein modification process	GO:0006464	100	0.012
axon development	GO:0061564	166	0.011
regulation of apoptotic process	GO:0042981	98	0.011
oocyte maturation	GO:0001556	4	0.011
muscle cell differentiation	GO:0042692	139	0.011
regulation of smoothened signaling pathway	GO:0008589	18	0.011
regulation of cell motility	GO:2000145	46	0.011
behavior	GO:0007610	74	0.011
regulation of canonical wnt signaling pathway	GO:0060828	34	0.011
regulation of epithelial cell proliferation	GO:0050678	3	0.011
regulation of cellular amino acid metabolic process	GO:0006521	0	0.011
negative regulation of signaling	GO:0023057	96	0.011
cardiac cell fate commitment	GO:0060911	1	0.011
spinal cord development	GO:0021510	46	0.011
locomotory behavior	GO:0007626	34	0.011
positive regulation of signaling	GO:0023056	56	0.011
cell death	GO:0008219	121	0.011
positive regulation of multicellular organismal process	GO:0051240	52	0.011
positive regulation of cytosolic calcium ion concentration	GO:0007204	4	0.011
regulation of mesoderm development	GO:2000380	11	0.011
microtubule organizing center organization	GO:0031023	1	0.011
endocrine pancreas development	GO:0031018	27	0.010
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.010
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.010
gall bladder development	GO:0061010	1	0.010
negative regulation of macromolecule metabolic process	GO:0010605	76	0.010
forebrain morphogenesis	GO:0048853	6	0.010
rostrocaudal neural tube patterning	GO:0021903	29	0.010
signal transduction downstream of smoothened	GO:0007227	1	0.010

cdx1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.195
musculoskeletal system disease	DOID:17	0.034
nervous system disease	DOID:863	0.019
disease of metabolism	DOID:0014667	0.019
cardiovascular system disease	DOID:1287	0.018
diabetes mellitus	DOID:9351	0.015
glucose metabolism disease	DOID:4194	0.015
acquired metabolic disease	DOID:0060158	0.015
carbohydrate metabolism disease	DOID:0050013	0.015
type 2 diabetes mellitus	DOID:9352	0.015
connective tissue disease	DOID:65	0.015
inherited metabolic disorder	DOID:655	0.014
electroclinical syndrome	DOID:0050701	0.013
brain disease	DOID:936	0.013
central nervous system disease	DOID:331	0.013
epilepsy syndrome	DOID:1826	0.013
dysostosis	DOID:1934	0.011
bone development disease	DOID:0080006	0.011
bone disease	DOID:0080001	0.011

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