Danio rerio

84 known processes

pink1

PTEN induced putative kinase 1

(Aliases: wu:fc39e12,zgc:101729)

pink1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cell projection organizationGO:00300302840.774
Worm
g protein coupled receptor signaling pathwayGO:0007186740.465
positive regulation of biological processGO:00485182530.462
Human Mouse Fly
brain developmentGO:00074202930.452
response to external stimulusGO:00096052640.433
Worm
single organism transportGO:00447652060.404
Mouse
regulation of homeostatic processGO:003284490.350
adult behaviorGO:003053420.346
positive regulation of transportGO:005105020.332
Mouse
sequestering of metal ionGO:005123830.283
ion transportGO:00068111140.279
Mouse
startle responseGO:000196440.274
cognitionGO:005089010.233
neuron projection developmentGO:00311751800.226
Worm
positive regulation of cellular processGO:00485222010.201
Human Mouse Fly
regulation of biological qualityGO:00650082630.200
cytoskeleton organizationGO:0007010960.195
signal transductionGO:00071654550.193
neuron differentiationGO:00301823530.185
response to abiotic stimulusGO:00096281220.175
Human Mouse
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.167
regulation of sequestering of calcium ionGO:005128240.167
macromolecular complex subunit organizationGO:0043933740.164
Human
organic substance transportGO:0071702580.155
Mouse
blood vessel morphogenesisGO:00485142160.150
response to oxygen levelsGO:0070482250.150
Human Mouse
positive regulation of camp biosynthetic processGO:003081920.148
cellular component assemblyGO:00226071700.146
Human
vasculature developmentGO:00019442780.145
cell morphogenesisGO:00009022890.142
Worm
angiogenesisGO:00015251580.139
cell migrationGO:00164772370.132
transmembrane transportGO:00550851200.128
central nervous system neuron axonogenesisGO:0021955180.124
anion transportGO:0006820380.114
glucose importGO:004632320.114
neuron neuron synaptic transmissionGO:000727010.113
Mouse
head developmentGO:00603223030.113
cytosolic calcium ion transportGO:006040130.110
calcium ion transport into cytosolGO:006040230.107
detection of stimulusGO:0051606290.107
regulation of synaptic plasticityGO:004816710.105
neuron projection extensionGO:1990138450.103
Worm
regulation of dendrite developmentGO:005077330.101
cellular response to decreased oxygen levelsGO:003629410.097
Human Mouse
establishment of localizationGO:00512342440.095
Mouse
transportGO:00068102200.093
Mouse
generation of neuronsGO:00486993850.093
regulation of receptor activityGO:001046920.092
positive regulation of cellular component biogenesisGO:004408930.087
regulation of fatty acid metabolic processGO:001921710.085
spermatid developmentGO:000728620.085
behaviorGO:0007610740.083
negative regulation of sequestering of calcium ionGO:005128340.080
organelle transport along microtubuleGO:007238410.079
response to osmotic stressGO:0006970110.077
positive regulation of secretion by cellGO:190353210.076
Mouse
positive regulation of cytosolic calcium ion concentrationGO:000720440.074
single organism metabolic processGO:00447102170.073
Mouse
actin filament based processGO:0030029640.073
regulation of signalingGO:00230512350.071
cell part morphogenesisGO:00329902460.071
Worm
neurological system processGO:0050877620.071
sequestering of calcium ionGO:005120830.070
negative regulation of cellular processGO:00485232830.069
Human Mouse Fly
receptor internalizationGO:003162320.069
cell surface receptor signaling pathwayGO:00071663250.069
single organism localizationGO:19025782250.066
Mouse
peptidyl serine phosphorylationGO:001810510.065
Human
reactive nitrogen species metabolic processGO:200105700.065
cerebellum vasculature developmentGO:006130010.064
regulation of postsynaptic membrane potentialGO:006007810.062
cellular component morphogenesisGO:00329893360.061
Worm
detection of abiotic stimulusGO:0009582240.061
localization of cellGO:00516742440.061
inner ear developmentGO:00488391260.060
regulation of cell communicationGO:00106462320.060
protein complex biogenesisGO:0070271300.058
Human
cell projection assemblyGO:0030031640.057
neuron developmentGO:00486662620.056
Worm
axon guidanceGO:0007411860.054
Worm
positive regulation of epithelial cell proliferationGO:005067910.054
maintenance of locationGO:005123540.054
central nervous system developmentGO:00074173870.053
cellular localizationGO:0051641970.053
Mouse
synaptic transmissionGO:0007268350.052
Mouse Fly
regulation of filopodium assemblyGO:005148920.051
positive regulation of secretionGO:005104710.051
Mouse
amine metabolic processGO:000930820.050
macromolecular complex disassemblyGO:003298410.049
regulation of cell projection organizationGO:0031344440.049
cation homeostasisGO:0055080330.046
cell motilityGO:00488702440.046
locomotory behaviorGO:0007626340.045
central nervous system neuron differentiationGO:0021953740.045
cellular response to hypoxiaGO:007145610.042
Human Mouse
positive regulation of erk1 and erk2 cascadeGO:007037420.042
regulation of nucleobase containing compound metabolic processGO:00192192500.041
Mouse
regulation of rac protein signal transductionGO:003502010.041
cellular component biogenesisGO:00440851780.040
Human
cell proliferationGO:0008283800.040
aromatic compound biosynthetic processGO:00194382170.039
Mouse
hydrogen peroxide metabolic processGO:004274320.039
Mouse
regulation of neuron projection developmentGO:0010975400.039
positive regulation of striated muscle tissue developmentGO:004584410.039
osteoclast developmentGO:003603510.038
regulation of membrane potentialGO:0042391230.038
Human
locomotionGO:00400113130.038
Worm
nuclear migrationGO:000709730.038
regulation of dendrite morphogenesisGO:004881430.038
bicarbonate transportGO:001570140.038
brain morphogenesisGO:0048854180.038
carbohydrate transportGO:0008643130.037
protein complex subunit organizationGO:0071822460.037
Human
semicircular canal developmentGO:0060872240.037
muscle cell migrationGO:001481240.037
organic substance biosynthetic processGO:19015762890.036
Mouse
embryonic skeletal joint developmentGO:007249830.036
response to chemicalGO:00422213200.035
actin polymerization or depolymerizationGO:000815420.035
positive regulation of muscle organ developmentGO:004863610.034
regulation of cellular component organizationGO:0051128860.033
Human Fly
ras protein signal transductionGO:000726570.033
cell deathGO:00082191210.033
response to dexamethasoneGO:007154810.033
cellular response to external stimulusGO:007149620.032
growthGO:00400071740.032
Worm
regulation of reproductive processGO:200024140.031
establishment of localization in cellGO:0051649770.031
Mouse
synapsisGO:000712910.031
cellular component movementGO:00069283350.031
Worm
dopaminergic neuron differentiationGO:0071542140.030
microtubule based movementGO:0007018330.030
multicellular organism growthGO:003526440.030
protein importGO:001703830.029
cellular component disassemblyGO:002241110.029
actin filament polymerizationGO:003004120.029
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.029
positive regulation of exocytosisGO:004592110.029
cellular response to chemical stimulusGO:00708871570.028
regulation of glucose importGO:004632410.028
erk1 and erk2 cascadeGO:007037140.028
deathGO:00162651210.028
blood vessel developmentGO:00015682460.028
purine ribonucleoside monophosphate catabolic processGO:000916940.028
developmental growthGO:00485891660.027
Worm
multicellular organismal metabolic processGO:004423620.027
centrosome organizationGO:005129710.027
cellular carbohydrate metabolic processGO:004426240.027
nitric oxide biosynthetic processGO:000680920.027
positive regulation of metabolic processGO:00098931080.026
Human Mouse
positive regulation of catabolic processGO:000989640.026
central nervous system projection neuron axonogenesisGO:0021952150.026
circadian sleep wake cycle processGO:002241020.026
regulation of transporter activityGO:003240920.026
calcium mediated signalingGO:001972220.026
cellular response to extracellular stimulusGO:003166820.026
neural nucleus developmentGO:0048857150.025
ribose phosphate metabolic processGO:0019693270.025
microtubule organizing center organizationGO:003102310.025
negative regulation of dna metabolic processGO:005105340.025
response to ketoneGO:190165410.025
spermatid differentiationGO:004851520.025
locus ceruleus developmentGO:002170330.024
centrosome cycleGO:000709810.024
regulation of exocytosisGO:001715710.024
regulation of multicellular organismal processGO:00512392770.024
glial cell proliferationGO:001400940.024
positive regulation of cytoskeleton organizationGO:005149530.024
cell cell signalingGO:0007267520.024
Mouse Fly
peptidyl serine modificationGO:001820920.023
Human
multi organism processGO:00517041340.023
pronuclear migrationGO:003504610.023
regulation of ion homeostasisGO:200002170.023
regulation of ion transmembrane transporter activityGO:003241220.023
cellular cation homeostasisGO:0030003170.023
response to stressGO:00069502630.023
Human Mouse Worm Fly
system processGO:00030081850.023
synaptic growth at neuromuscular junctionGO:005112420.023
reactive oxygen species biosynthetic processGO:190340910.023
organic cyclic compound metabolic processGO:19013603010.023
Mouse
cellular response to nutrient levelsGO:003166920.022
neuropeptide signaling pathwayGO:0007218110.022
establishment of synaptic vesicle localizationGO:009748010.022
retrograde axon cargo transportGO:000809010.022
developmental maturationGO:0021700340.022
regulation of camp biosynthetic processGO:003081790.022
regulation of cell shapeGO:000836010.022
cellular macromolecule biosynthetic processGO:00346452240.022
Mouse
regulation of neurogenesisGO:0050767870.022
regulation of cellular amine metabolic processGO:003323800.022
mrna 3 end processingGO:003112420.022
organic acid metabolic processGO:0006082310.021
neurotransmitter secretionGO:000726920.021
cell projection morphogenesisGO:00488582440.021
Worm
organelle organizationGO:00069962270.021
negative regulation of signal transduction in absence of ligandGO:190109910.021
cellular response to stressGO:0033554620.021
Human Mouse Worm
hexose transportGO:000864560.020
ear developmentGO:00435831270.020
cerebellum morphogenesisGO:0021587100.020
regulation of neurological system processGO:003164420.020
regulation of phGO:000688530.020
nucleobase containing small molecule metabolic processGO:0055086320.020
phototransduction visible lightGO:000760320.020
intracellular transportGO:0046907320.020
cellular response to organic substanceGO:00713101050.020
cell maturationGO:0048469230.020
regulation of molecular functionGO:0065009700.019
Mouse
regulation of developmental processGO:00507932470.019
Fly
larval developmentGO:000216420.019
single organism organelle organizationGO:19025891990.019
Fly
regulation of localizationGO:00328791040.019
Mouse
nucleobase containing compound biosynthetic processGO:00346542050.019
Mouse
regulation of cellular component sizeGO:0032535300.019
response to light stimulusGO:0009416460.019
chemotaxisGO:00069351040.019
Worm
centrosome localizationGO:005164210.019
cellular ion homeostasisGO:0006873170.019
positive regulation of cellular amino acid metabolic processGO:004576400.019
regulation of meiotic cell cycleGO:005144510.019
heterocycle metabolic processGO:00464832900.018
Mouse
dicarboxylic acid transportGO:000683510.018
negative regulation of biological processGO:00485193040.018
Human Mouse Fly
taste bud morphogenesisGO:006119430.018
regulation of cellular biosynthetic processGO:00313262450.018
Mouse
metencephalon developmentGO:0022037270.018
nitric oxide metabolic processGO:004620920.018
cellular amine metabolic processGO:004410620.017
mitotic cell cycleGO:0000278640.017
regulation of circadian rhythmGO:004275240.017
steroid hormone mediated signaling pathwayGO:004340190.017
regulation of cell migrationGO:0030334400.017
cellular component maintenanceGO:004395430.017
fatty acid biosynthetic processGO:000663340.017
regulation of nervous system developmentGO:0051960900.017
fertilizationGO:000956630.017
cellular monovalent inorganic cation homeostasisGO:003000420.017
indole containing compound biosynthetic processGO:004243510.017
positive regulation of wound healingGO:009030310.017
purine nucleotide metabolic processGO:0006163270.017
regulation of cytoplasmic transportGO:190364940.016
heterocycle biosynthetic processGO:00181302150.016
Mouse
regulation of locomotionGO:0040012550.016
rna 3 end processingGO:003112320.016
peripheral nervous system neuron axonogenesisGO:0048936130.016
cellular protein catabolic processGO:004425740.016
Fly
regulation of neuron differentiationGO:0045664560.016
regulation of multicellular organism growthGO:004001440.016
regulation of intracellular protein transportGO:003315730.016
nuclear envelope organizationGO:000699820.016
striated muscle cell differentiationGO:00511461290.016
metal ion homeostasisGO:0055065260.016
hindbrain developmentGO:0030902910.016
reproductive processGO:0022414400.016
Fly
multicellular organismal water homeostasisGO:005089110.016
cellular respirationGO:004533330.016
Mouse
cellular response to topologically incorrect proteinGO:003596720.016
neuron projection guidanceGO:0097485860.016
Worm
vasculogenesisGO:0001570410.016
regulation of protein modification by small protein conjugation or removalGO:190332030.015
Human
regulation of heart growthGO:006042020.015
regulation of metal ion transportGO:001095940.015
small gtpase mediated signal transductionGO:000726480.015
regulation of extent of cell growthGO:0061387290.015
muscle structure developmentGO:00610611960.015
regulation of multicellular organismal developmentGO:20000262230.015
regulation of protein ubiquitinationGO:003139630.015
Human
regulation of phospholipase activityGO:001051720.015
regulation of calcium ion transportGO:005192420.015
small molecule metabolic processGO:0044281770.015
organelle localizationGO:0051640490.014
locomotor rhythmGO:004547530.014
regulation of n methyl d aspartate selective glutamate receptor activityGO:200031010.014
positive regulation of striated muscle cell differentiationGO:005115510.014
response to organic substanceGO:00100331530.014
negative regulation of signalingGO:0023057960.014
Human Mouse
regulation of rho protein signal transductionGO:003502320.014
response to amphetamineGO:000197510.014
regulation of signal transductionGO:00099662250.014
protein complex disassemblyGO:004324110.014
cerebellum developmentGO:0021549170.014
positive regulation of nitrogen compound metabolic processGO:0051173690.014
regulation of purine nucleotide biosynthetic processGO:1900371150.014
regulation of erk1 and erk2 cascadeGO:007037240.014
purine ribonucleotide metabolic processGO:0009150270.014
regulation of glutamate receptor signaling pathwayGO:190044910.014
protein metabolic processGO:00195381830.014
Human Mouse Fly
positive regulation of cyclic nucleotide biosynthetic processGO:003080480.014
positive regulation of muscle tissue developmentGO:190186310.013
regulation of transmembrane transporter activityGO:002289820.013
circadian sleep wake cycleGO:004274520.013
regulation of primary metabolic processGO:00800903110.013
Human Mouse
microtubule based transportGO:0010970100.013
single organism nuclear importGO:190259330.013
negative regulation of dna replicationGO:000815620.013
regulation of endothelial cell proliferationGO:000193610.013
negative regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200124010.013
response to cortisolGO:005141410.013
organonitrogen compound biosynthetic processGO:1901566470.013
regulation of developmental growthGO:0048638380.013
toxin transportGO:190199820.013
single organism intracellular transportGO:1902582250.013
regulation of phosphorus metabolic processGO:0051174430.013
Human Mouse
neural tube patterningGO:0021532330.013
establishment of protein localization to organelleGO:007259440.013
organonitrogen compound metabolic processGO:1901564740.013
sensory organ developmentGO:00074233930.013
negative regulation of catabolic processGO:000989530.013
regulation of ras gtpase activityGO:003231820.012
regulation of dna replicationGO:000627530.012
positive regulation of transcription dna templatedGO:0045893570.012
proteolysis involved in cellular protein catabolic processGO:005160330.012
Fly
response to monosaccharideGO:003428430.012
growth plate cartilage morphogenesisGO:000342210.012
embryonic organ developmentGO:00485683810.012
regulation of cardiac muscle cell contractionGO:008600410.012
gtp metabolic processGO:004603940.012
establishment of organelle localizationGO:0051656450.012
protein polymerizationGO:005125840.012
cyclic nucleotide biosynthetic processGO:0009190180.012
rac protein signal transductionGO:001660110.012
negative regulation of programmed cell deathGO:0043069580.012
Human Mouse Fly
regulation of behaviorGO:0050795240.012
nitrogen compound metabolic processGO:00068073190.012
Mouse
neuromuscular synaptic transmissionGO:000727420.012
Fly
light induced release of internally sequestered calcium ionGO:000837710.012
modification dependent macromolecule catabolic processGO:004363230.012
Fly
glucose transportGO:001575860.011
actin filament organizationGO:0007015150.011
microtubule depolymerizationGO:000701910.011
protein targeting to nucleusGO:004474430.011
rna stabilizationGO:004348940.011
rhodopsin mediated signaling pathwayGO:001605610.011
phosphorylationGO:0016310690.011
Human Mouse Fly
positive regulation of cellular amine metabolic processGO:003324000.011
positive regulation of nucleotide biosynthetic processGO:003081080.011
regulation of microtubule based movementGO:006063230.011
cerebellar granular layer formationGO:002168430.011
pyruvate metabolic processGO:000609010.011
osteoclast differentiationGO:003031610.011
cellular transition metal ion homeostasisGO:004691630.011
regulation of skeletal muscle tissue developmentGO:004864140.011
positive regulation of signal transductionGO:0009967560.011
Human
sensory perception of painGO:001923310.011
positive regulation of purine nucleotide biosynthetic processGO:190037380.011
organic cyclic compound biosynthetic processGO:19013622230.011
Mouse
actin filament based movementGO:003004810.011
apoptotic processGO:00069151160.011
synaptic transmission cholinergicGO:000727140.011
membrane repolarizationGO:008600920.011
regulation of blood circulationGO:1903522320.011
g1 s transition of mitotic cell cycleGO:000008210.011
cellular nitrogen compound metabolic processGO:00346412900.011
Mouse
single organism cellular localizationGO:1902580460.011
negative regulation of locomotionGO:0040013180.011
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.011
bone remodelingGO:004684920.011
single organism behaviorGO:0044708240.010
positive regulation of cell cycleGO:004578730.010
otolith developmentGO:0048840320.010
regulation of organelle organizationGO:0033043290.010
Human Fly
intracellular signal transductionGO:0035556850.010
Human Mouse
regulation of protein polymerizationGO:003227120.010
primary neural tube formationGO:001402010.010
ubiquitin dependent protein catabolic processGO:000651130.010
Fly
muscle tissue developmentGO:00605371100.010
negative regulation of mitosisGO:004583930.010
carbohydrate derivative biosynthetic processGO:1901137430.010
carboxylic acid metabolic processGO:0019752220.010
regulation of response to cytokine stimulusGO:006075930.010
spindle assemblyGO:005122520.010
developmental cell growthGO:0048588520.010
Worm
protein complex assemblyGO:0006461300.010
Human
negative regulation of secretionGO:005104820.010

pink1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.040
congenital nervous system abnormalityDOID:249000.027
physical disorderDOID:008001500.027
lissencephalyDOID:005045300.027
nervous system diseaseDOID:86300.020
Human
disease of anatomical entityDOID:700.020
Human
synucleinopathyDOID:005089000.013
Human
central nervous system diseaseDOID:33100.013
Human
neurodegenerative diseaseDOID:128900.013
Human
parkinson s diseaseDOID:1433000.013
Human