Danio rerio

27 known processes

smtlb

somatolactin beta

(Aliases: MGC152704,slb)

smtlb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of metabolic processGO:00192223590.252
Zebrafish
cellular nitrogen compound metabolic processGO:00346412900.155
signal transductionGO:00071654550.130
regulation of primary metabolic processGO:00800903110.128
Zebrafish
agingGO:000756820.127
generation of neuronsGO:00486993850.122
rna biosynthetic processGO:00327741810.120
cellular nitrogen compound biosynthetic processGO:00442712180.115
organic substance biosynthetic processGO:19015762890.115
regulation of biosynthetic processGO:00098892500.110
response to external stimulusGO:00096052640.110
nitrogen compound metabolic processGO:00068073190.108
larval developmentGO:000216420.104
cellular macromolecule metabolic processGO:00442603910.101
cellular biosynthetic processGO:00442492860.099
regulation of cellular macromolecule biosynthetic processGO:20001122220.099
regulation of cellular metabolic processGO:00313233200.092
nucleic acid metabolic processGO:00903042440.090
organic cyclic compound biosynthetic processGO:19013622230.088
transcription dna templatedGO:00063511810.088
embryonic organ developmentGO:00485683810.085
cell surface receptor signaling pathwayGO:00071663250.085
cellular macromolecule biosynthetic processGO:00346452240.084
nucleic acid templated transcriptionGO:00976591810.082
heterocycle biosynthetic processGO:00181302150.082
biosynthetic processGO:00090582940.081
central nervous system developmentGO:00074173870.079
organic cyclic compound metabolic processGO:19013603010.079
neuron neuron synaptic transmissionGO:000727010.079
multicellular organism growthGO:003526440.078
response to stressGO:00069502630.077
gland developmentGO:00487321430.077
cognitionGO:005089010.076
aromatic compound biosynthetic processGO:00194382170.076
regulation of cellular biosynthetic processGO:00313262450.073
regulation of nucleobase containing compound metabolic processGO:00192192500.071
head developmentGO:00603223030.069
macromolecule biosynthetic processGO:00090592270.067
heterocycle metabolic processGO:00464832900.067
immune system processGO:00023762410.066
regulation of multicellular organism growthGO:004001440.066
regulation of biological qualityGO:00650082630.066
homeostatic processGO:00425921420.065
regulation of multicellular organismal processGO:00512392770.064
regulation of rna biosynthetic processGO:20011412130.061
regulation of rna metabolic processGO:00512522240.060
maintenance of locationGO:005123540.059
nucleobase containing compound metabolic processGO:00061392740.058
nuclear transportGO:005116940.058
gene expressionGO:00104672520.057
regulation of gene expressionGO:00104682650.057
negative regulation of sequestering of calcium ionGO:005128340.057
brain developmentGO:00074202930.056
positive regulation of nitrogen compound metabolic processGO:0051173690.054
eye developmentGO:00016542770.054
establishment of protein localization to organelleGO:007259440.054
localization of cellGO:00516742440.054
sensory perception of painGO:001923310.053
regulation of transcription dna templatedGO:00063552130.053
hemopoiesisGO:00300971830.053
nucleocytoplasmic transportGO:000691340.053
transcription from rna polymerase ii promoterGO:0006366800.052
regulation of metal ion transportGO:001095940.052
regulation of macromolecule biosynthetic processGO:00105562250.050
protein localization to nucleusGO:003450430.050
nucleobase containing compound biosynthetic processGO:00346542050.049
g protein coupled receptor signaling pathwayGO:0007186740.049
cellular aromatic compound metabolic processGO:00067252950.049
sequestering of calcium ionGO:005120830.048
chemosensory behaviorGO:000763510.048
female gonad developmentGO:000858540.047
negative regulation of biological processGO:00485193040.047
Zebrafish
positive regulation of cytosolic calcium ion concentrationGO:000720440.047
female sex differentiationGO:004666040.047
sequestering of metal ionGO:005123830.047
positive regulation of biological processGO:00485182530.045
Zebrafish
regulation of transcription from rna polymerase ii promoterGO:00063571140.045
camera type eye developmentGO:00430102220.045
lipid catabolic processGO:001604240.044
Zebrafish
multi organism processGO:00517041340.044
regulation of establishment of protein localizationGO:007020140.044
small molecule metabolic processGO:0044281770.043
regulation of macromolecule metabolic processGO:00602553170.043
rna metabolic processGO:00160702190.043
nuclear importGO:005117030.043
chordate embryonic developmentGO:00430092710.043
ion transmembrane transportGO:0034220910.043
regulation of nucleic acid templated transcriptionGO:19035062130.042
protein targeting to nucleusGO:004474430.042
endocrine system developmentGO:0035270650.040
regulation of calcium ion transportGO:005192420.040
protein importGO:001703830.040
cellular modified amino acid metabolic processGO:000657530.039
positive regulation of cellular biosynthetic processGO:0031328680.039
lipid storageGO:001991510.039
endocrine processGO:005088620.038
immune system developmentGO:00025201910.038
sleepGO:003043110.038
developmental growthGO:00485891660.038
monovalent inorganic cation transportGO:0015672420.038
segmentationGO:0035282970.038
protein import into nucleusGO:000660630.037
cell migrationGO:00164772370.037
single organism metabolic processGO:00447102170.037
Zebrafish
response to organic substanceGO:00100331530.037
regulation of neuronal synaptic plasticityGO:004816810.037
intracellular receptor signaling pathwayGO:0030522300.036
transportGO:00068102200.036
neurological system processGO:0050877620.036
cell projection morphogenesisGO:00488582440.036
system processGO:00030081850.035
cell part morphogenesisGO:00329902460.035
neuron differentiationGO:00301823530.034
positive regulation of transportGO:005105020.034
regulation of protein import into nucleusGO:004230620.034
regulation of protein localization to nucleusGO:190018020.034
regulation of signal transductionGO:00099662250.034
ovulation cycleGO:004269820.034
regulation of protein transportGO:005122330.033
regulation of circadian rhythmGO:004275240.033
i kappab kinase nf kappab signalingGO:000724940.033
diencephalon developmentGO:0021536580.032
regulation of response to stimulusGO:00485832690.032
tissue remodelingGO:004877140.031
cellular amino acid metabolic processGO:000652070.031
cytosolic calcium ion transportGO:006040130.031
growthGO:00400071740.031
regulation of nitrogen compound metabolic processGO:00511712510.031
hematopoietic or lymphoid organ developmentGO:00485341910.030
negative regulation of cellular processGO:00485232830.030
Zebrafish
response to amphetamineGO:000197510.030
regulation of sequestering of calcium ionGO:005128240.030
regulation of synapse organizationGO:005080730.030
blood vessel developmentGO:00015682460.030
regulation of cellular amine metabolic processGO:003323800.030
calcium ion transport into cytosolGO:006040230.030
response to nutrientGO:000758430.030
regulation of cytoplasmic transportGO:190364940.029
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.029
positive regulation of cellular metabolic processGO:0031325940.029
organonitrogen compound metabolic processGO:1901564740.029
regulation of nucleocytoplasmic transportGO:004682220.028
response to chemicalGO:00422213200.028
single organism nuclear importGO:190259330.028
ion transportGO:00068111140.028
b cell activationGO:004211320.028
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.028
negative regulation of response to stimulusGO:00485851040.027
heart morphogenesisGO:00030071560.027
dicarboxylic acid transportGO:000683510.027
cellular component movementGO:00069283350.027
vasculature developmentGO:00019442780.027
morphogenesis of an epitheliumGO:00020093330.027
extrinsic apoptotic signaling pathwayGO:009719130.026
cell morphogenesisGO:00009022890.026
regulation of neural precursor cell proliferationGO:200017730.026
cellular localizationGO:0051641970.026
enzyme linked receptor protein signaling pathwayGO:00071671060.026
positive regulation of biosynthetic processGO:0009891680.026
cellular response to chemical stimulusGO:00708871570.026
cellular component morphogenesisGO:00329893360.026
apoptotic processGO:00069151160.026
Zebrafish
embryo development ending in birth or egg hatchingGO:00097922710.026
regulation of cell activationGO:005086510.025
digestive system developmentGO:00551232890.025
hormone transportGO:000991420.025
negative regulation of protein transportGO:005122430.025
deathGO:00162651210.025
Zebrafish
negative regulation of metabolic processGO:0009892860.025
neuron projection extensionGO:1990138450.025
regulation of carbohydrate metabolic processGO:000610940.025
regionalizationGO:00030022740.025
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.025
oxoacid metabolic processGO:0043436310.025
cellular carbohydrate metabolic processGO:004426240.025
response to external biotic stimulusGO:0043207970.024
peptide transportGO:001583310.024
cellular response to organic substanceGO:00713101050.024
transmembrane transportGO:00550851200.024
response to drugGO:004249330.024
establishment of localizationGO:00512342440.024
neurotransmitter transportGO:000683620.024
cellular response to external stimulusGO:007149620.024
cellular amide metabolic processGO:004360340.024
regulation of cell communicationGO:00106462320.023
regulation of protein complex assemblyGO:004325430.023
regulation of synaptic plasticityGO:004816710.023
response to alkaloidGO:004327920.023
axon developmentGO:00615641660.023
developmental growth involved in morphogenesisGO:0060560860.023
regulation of protein targetingGO:190353320.023
stem cell proliferationGO:007208940.023
lateral inhibitionGO:004633110.023
regulation of synapse assemblyGO:005196330.023
regulation of erk1 and erk2 cascadeGO:007037240.022
regulation of cellular amino acid metabolic processGO:000652100.022
locomotionGO:00400113130.022
sensory organ developmentGO:00074233930.022
release of sequestered calcium ion into cytosolGO:005120930.022
programmed cell deathGO:00125011190.022
Zebrafish
positive regulation of nucleobase containing compound metabolic processGO:0045935690.022
development of primary female sexual characteristicsGO:004654540.022
cellular component assemblyGO:00226071700.022
organic acid metabolic processGO:0006082310.022
negative regulation of rna metabolic processGO:0051253480.022
positive regulation of macromolecule metabolic processGO:0010604930.021
positive regulation of gene expressionGO:0010628710.021
cell morphogenesis involved in differentiationGO:00009041950.021
cellular amine metabolic processGO:004410620.021
sensory perception of chemical stimulusGO:000760630.021
forebrain developmentGO:0030900960.021
neuroblast proliferationGO:000740520.021
amine metabolic processGO:000930820.021
single organism localizationGO:19025782250.021
leukocyte differentiationGO:0002521250.021
negative regulation of macromolecule metabolic processGO:0010605760.021
liver developmentGO:0001889960.021
positive regulation of cellular amine metabolic processGO:003324000.021
ovulation cycle processGO:002260220.021
cytokinesisGO:000091030.021
mitochondrion organizationGO:000700540.020
regulation of cellular carbohydrate metabolic processGO:001067540.020
somitogenesisGO:0001756870.020
regulation of dna replicationGO:000627530.020
positive regulation of cellular component biogenesisGO:004408930.020
neuron projection developmentGO:00311751800.020
regulation of transporter activityGO:003240920.020
regulation of inflammatory responseGO:005072720.020
positive regulation of dna metabolic processGO:005105410.020
response to lipidGO:0033993600.020
anterior posterior pattern specificationGO:00099521520.020
metal ion transportGO:0030001580.020
negative regulation of protein kinase activityGO:000646940.020
erk1 and erk2 cascadeGO:007037140.020
hindbrain developmentGO:0030902910.020
translational initiationGO:000641330.019
muscle cell differentiationGO:00426921390.019
digestive tract developmentGO:00485652650.019
negative regulation of nitrogen compound metabolic processGO:0051172590.019
cellular ketone metabolic processGO:0042180110.019
blood vessel morphogenesisGO:00485142160.019
phagocytosisGO:000690930.019
fertilizationGO:000956630.019
wnt signaling pathwayGO:0016055800.019
protein secretionGO:000930610.019
positive regulation of cellular processGO:00485222010.019
regenerationGO:0031099910.019
positive regulation of nucleic acid templated transcriptionGO:1903508570.019
cellular component biogenesisGO:00440851780.019
cellular response to biotic stimulusGO:007121630.019
cellular component disassemblyGO:002241110.018
response to woundingGO:00096111160.018
protein modification processGO:00362111000.018
inorganic cation transmembrane transportGO:0098662500.018
eye morphogenesisGO:00485921440.018
regulation of blood vessel sizeGO:005088020.018
single organism biosynthetic processGO:0044711710.018
ventral spinal cord developmentGO:0021517350.018
embryonic pattern specificationGO:0009880440.018
single organism transportGO:00447652060.018
negative regulation of gene expressionGO:0010629650.018
negative regulation of nucleobase containing compound metabolic processGO:0045934590.018
positive regulation of i kappab kinase nf kappab signalingGO:004312330.018
energy reserve metabolic processGO:000611220.018
somite developmentGO:0061053960.018
chemical homeostasisGO:0048878490.018
meiotic nuclear divisionGO:000712640.018
negative regulation of cytoplasmic transportGO:190365020.018
circadian sleep wake cycle sleepGO:005080210.018
response to endogenous stimulusGO:0009719830.017
polyol metabolic processGO:001975110.017
carboxylic acid metabolic processGO:0019752220.017
regulation of cellular ketone metabolic processGO:001056570.017
response to biotic stimulusGO:0009607970.017
cellular response to hormone stimulusGO:0032870390.017
regulation of protein catabolic processGO:004217610.017
negative regulation of biosynthetic processGO:0009890550.017
digestive tract morphogenesisGO:00485462310.017
cell projection organizationGO:00300302840.017
response to oxygen levelsGO:0070482250.017
heart developmentGO:00075073130.017
negative regulation of reproductive processGO:200024230.017
negative regulation of protein phosphorylationGO:000193340.017
regulation of reproductive processGO:200024140.017
negative regulation of kinase activityGO:003367340.017
regulation of cellular component organizationGO:0051128860.017
negative regulation of protein import into nucleusGO:004230820.017
regulation of developmental processGO:00507932470.017
positive regulation of cell cycleGO:004578730.017
axonogenesisGO:00074091520.017
response to other organismGO:0051707970.017
regulation of growthGO:0040008420.017
adult behaviorGO:003053420.017
regulation of multicellular organismal developmentGO:20000262230.017
regulation of cellular component movementGO:0051270550.017
regulation of hormone secretionGO:004688320.017
mononuclear cell proliferationGO:003294310.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
positive regulation of rna metabolic processGO:0051254590.017
neuron projection morphogenesisGO:00488121610.017
myeloid cell differentiationGO:0030099860.016
positive regulation of macromolecule biosynthetic processGO:0010557590.016
cellular response to extracellular stimulusGO:003166820.016
lymphocyte proliferationGO:004665110.016
regulation of ion transmembrane transporter activityGO:003241220.016
regulation of intracellular protein transportGO:003315730.016
negative regulation of cellular biosynthetic processGO:0031327550.016
hormone secretionGO:004687920.016
regulation of blood pressureGO:000821710.016
dorsal ventral pattern formationGO:00099531250.016
inner ear developmentGO:00488391260.016
negative regulation of signal transductionGO:0009968940.016
camera type eye morphogenesisGO:00485931080.016
neuron developmentGO:00486662620.016
regulation of organ growthGO:004662030.016
regulation of signalingGO:00230512350.016
mechanosensory behaviorGO:000763820.016
protein polymerizationGO:005125840.016
tube morphogenesisGO:00352393490.016
cell motilityGO:00488702440.016
angiogenesisGO:00015251580.016
response to amineGO:001407510.015
positive regulation of rna biosynthetic processGO:1902680570.015
negative regulation of nucleic acid templated transcriptionGO:1903507450.015
cellular response to endogenous stimulusGO:0071495680.015
regulation of anatomical structure morphogenesisGO:00226031300.015
positive regulation of metabolic processGO:00098931080.015
Zebrafish
endocrine hormone secretionGO:006098620.015
inorganic ion transmembrane transportGO:0098660570.015
regulation of neurological system processGO:003164420.015
regulation of synaptic growth at neuromuscular junctionGO:000858210.015
leukocyte proliferationGO:007066110.015
positive regulation of protein complex assemblyGO:003133420.015
cell substrate adhesionGO:003158940.015
circadian sleep wake cycleGO:004274520.015
negative regulation of transcription dna templatedGO:0045892450.015
negative regulation of rna biosynthetic processGO:1902679450.015
guanosine containing compound catabolic processGO:190106920.015
positive regulation of immune effector processGO:000269930.015
behaviorGO:0007610740.015
positive regulation of catabolic processGO:000989640.015
Zebrafish
regulation of nervous system developmentGO:0051960900.015
negative regulation of catabolic processGO:000989530.015
carbohydrate derivative biosynthetic processGO:1901137430.015
ameboidal type cell migrationGO:00016671430.015
embryonic organ morphogenesisGO:00485622740.015
lymphangiogenesisGO:0001946250.015
regulation of transmembrane transporter activityGO:002289820.014
neurotransmitter secretionGO:000726920.014
organophosphate biosynthetic processGO:0090407230.014
negative regulation of intracellular transportGO:003238730.014
specification of symmetryGO:00097992040.014
regulation of stem cell differentiationGO:200073640.014
carbohydrate homeostasisGO:003350010.014
response to amino acidGO:004320020.014
regulation of circadian sleep wake cycleGO:004274910.014
response to glucocorticoidGO:005138410.014
positive regulation of apoptotic signaling pathwayGO:200123510.014
circadian sleep wake cycle processGO:002241020.014
regulation of circadian sleep wake cycle sleepGO:004518710.014
cellular response to nutrient levelsGO:003166920.014
developmental cell growthGO:0048588520.014
developmental programmed cell deathGO:001062340.014
negative regulation of signalingGO:0023057960.014
insulin like growth factor receptor signaling pathwayGO:004800940.014
muscle cell developmentGO:00550011150.014
regulation of dendrite developmentGO:005077330.014
cation transportGO:0006812810.014
organophosphate metabolic processGO:0019637370.014
sensory organ morphogenesisGO:00905962000.014
mesenchyme developmentGO:00604851270.014
membrane fusionGO:006102520.014
synaptic growth at neuromuscular junctionGO:005112420.014
regulation of i kappab kinase nf kappab signalingGO:004312240.014
nucleoside monophosphate catabolic processGO:000912540.014
intracellular signal transductionGO:0035556850.014
regulation of microtubule cytoskeleton organizationGO:007050730.014
cation transmembrane transportGO:0098655650.014
negative regulation of nucleocytoplasmic transportGO:004682320.013
amide biosynthetic processGO:004360410.013
multicellular organismal response to stressGO:003355520.013
negative regulation of macromolecule biosynthetic processGO:0010558480.013
cellular response to oxygen levelsGO:007145310.013
amino acid transportGO:000686520.013
negative regulation of protein localization to nucleusGO:190018120.013
regulation of cell developmentGO:00602841000.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.013
organic acid catabolic processGO:001605430.013
regulation of bone remodelingGO:004685020.013
regulation of cell substrate adhesionGO:001081010.013
guanosine containing compound metabolic processGO:190106840.013
protein metabolic processGO:00195381830.013
regulation of tube sizeGO:003515020.013
positive regulation of cytoskeleton organizationGO:005149530.013
positive regulation of reproductive processGO:200024320.013
cellular response to lipopolysaccharideGO:007122230.013
sensory perception of smellGO:000760820.013
regulation of bindingGO:005109830.013
positive regulation of cellular catabolic processGO:003133130.013
bone remodelingGO:004684920.013
small molecule catabolic processGO:004428230.013
inositol lipid mediated signalingGO:004801720.013
fluid transportGO:0042044170.013
negative regulation of cell communicationGO:0010648960.013
autophagyGO:000691440.013
positive regulation of secretionGO:005104710.012
pancreas developmentGO:0031016840.012
actin filament based movementGO:003004810.012
negative regulation of defense responseGO:003134820.012
response to carbohydrateGO:000974330.012
regulation of extrinsic apoptotic signaling pathwayGO:200123630.012
response to hormoneGO:0009725480.012
gtp metabolic processGO:004603940.012
b cell differentiationGO:003018310.012
glucose homeostasisGO:004259310.012
macromolecular complex disassemblyGO:003298410.012
organelle organizationGO:00069962270.012
modification dependent macromolecule catabolic processGO:004363230.012
stem cell maintenanceGO:001982740.012
regulation of dendrite morphogenesisGO:004881430.012
gtp catabolic processGO:000618420.012
regulation of locomotionGO:0040012550.012
actin mediated cell contractionGO:007025210.012
multicellular organismal metabolic processGO:004423620.012
embryonic viscerocranium morphogenesisGO:0048703520.012
response to abiotic stimulusGO:00096281220.012
negative regulation of nuclear divisionGO:005178430.012
determination of bilateral symmetryGO:00098552040.012
regulation of cell deathGO:00109411030.012
Zebrafish
positive regulation of leukocyte differentiationGO:190210710.012
positive regulation of carbohydrate metabolic processGO:004591310.012
positive regulation of cell activationGO:005086710.012
homeostasis of number of cellsGO:0048872620.012
regulation of jak stat cascadeGO:004642530.012
production of molecular mediator of immune responseGO:000244020.012
hepaticobiliary system developmentGO:0061008980.012
purine nucleoside monophosphate catabolic processGO:000912840.012
negative regulation of intracellular protein transportGO:009031730.012
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.012
adherens junction organizationGO:003433240.012
response to corticosteroidGO:003196010.012
striated muscle tissue developmentGO:00147061100.012
muscle tissue developmentGO:00605371100.012
regulation of neurotransmitter transportGO:005158810.012
peptidyl serine modificationGO:001820920.012
response to oxygen containing compoundGO:1901700550.012
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.012
photoreceptor cell differentiationGO:0046530550.012
ubiquitin dependent protein catabolic processGO:000651130.012
neuron fate commitmentGO:0048663260.011
cellular response to hypoxiaGO:007145610.011
blood circulationGO:0008015870.011
regulation of epithelial cell proliferationGO:005067830.011
positive regulation of transcription dna templatedGO:0045893570.011
negative regulation of dna metabolic processGO:005105340.011
cell growthGO:0016049570.011
striated muscle cell differentiationGO:00511461290.011
response to transition metal nanoparticleGO:1990267280.011
actin polymerization or depolymerizationGO:000815420.011
regulation of cell migrationGO:0030334400.011
peptide metabolic processGO:000651810.011
wound healingGO:0042060900.011
interspecies interaction between organismsGO:004441940.011
sensory perceptionGO:0007600390.011
muscle structure developmentGO:00610611960.011
central nervous system neuron differentiationGO:0021953740.011
regulation of systemic arterial blood pressureGO:000307310.011
cellular protein metabolic processGO:00442671290.011
establishment of synaptic vesicle localizationGO:009748010.011
proteolysis involved in cellular protein catabolic processGO:005160330.011
mesenchymal cell developmentGO:0014031780.011
cellular response to starvationGO:000926710.011
gabaergic neuron differentiationGO:009715420.011
tissue regenerationGO:0042246740.011
multicellular organismal homeostasisGO:0048871290.011
phosphatidylinositol 3 kinase signalingGO:001406520.011
response to monosaccharideGO:003428430.011
regulation of neuron differentiationGO:0045664560.011
establishment of localization in cellGO:0051649770.011
positive regulation of chromosome organizationGO:200125210.011
exocytosisGO:000688710.011
fatty acid transportGO:001590810.011
meiotic cell cycle processGO:190304630.011
cilium assemblyGO:0042384580.011
phosphorus metabolic processGO:00067931090.011
cellular response to decreased oxygen levelsGO:003629410.011
response to vitaminGO:003327330.011
regulation of cell differentiationGO:00455951420.011
protein complex disassemblyGO:004324110.011
apoptotic process involved in developmentGO:190274220.011
striated muscle cell developmentGO:00550021080.011
g1 s transition of mitotic cell cycleGO:000008210.011

smtlb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.015
disease of metabolismDOID:001466700.013
cardiovascular system diseaseDOID:128700.012
nervous system diseaseDOID:86300.011