Danio rerio

36 known processes

nkx6.1

NK6 transcription factor related, locus 1 (Drosophila)

(Aliases: zgc:92879)

nkx6.1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
ventral spinal cord interneuron differentiationGO:0021514120.960
Mouse
ventral spinal cord interneuron specificationGO:002152130.692
Mouse
type b pancreatic cell differentiationGO:000330980.657
macromolecule biosynthetic processGO:00090592270.610
Mouse Rat
ventral spinal cord developmentGO:0021517350.586
cerebellar granular layer formationGO:002168430.518
determination of left right symmetryGO:00073681790.507
Worm
positive regulation of biological processGO:00485182530.505
Mouse Rat
chordate embryonic developmentGO:00430092710.498
regulation of glial cell differentiationGO:004568540.482
Mouse
amino acid transportGO:000686520.438
positive regulation of glial cell differentiationGO:004568710.424
Mouse
generation of neuronsGO:00486993850.421
dorsal ventral pattern formationGO:00099531250.402
Mouse
spinal cord dorsal ventral patterningGO:002151350.363
Mouse
regulation of transcription involved in cell fate commitmentGO:006085010.362
Mouse
cell fate specification involved in pattern specificationGO:006057330.317
Mouse
regulation of canonical wnt signaling pathwayGO:0060828340.315
cell differentiation in hindbrainGO:002153350.269
spinal cord developmentGO:0021510460.259
cell fate commitmentGO:0045165990.256
cerebellar granule cell differentiationGO:002170730.249
pancreatic a cell developmentGO:000332220.242
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082340.235
glandular epithelial cell differentiationGO:000206790.223
pancreas developmentGO:0031016840.221
enteroendocrine cell differentiationGO:003588390.221
cell motilityGO:00488702440.218
Mouse
cerebellar granular layer developmentGO:002168130.209
regulation of nucleic acid templated transcriptionGO:19035062130.207
Mouse Rat
biosynthetic processGO:00090582940.203
Mouse Rat
response to chemicalGO:00422213200.202
Rat
cell differentiation in spinal cordGO:0021515400.200
central nervous system developmentGO:00074173870.200
astrocyte differentiationGO:004870810.172
regulation of membrane potentialGO:0042391230.169
cerebellar granular layer morphogenesisGO:002168330.161
positive regulation of cellular processGO:00485222010.157
Mouse Rat
central nervous system myelinationGO:002201020.155
determination of bilateral symmetryGO:00098552040.155
Worm
cell morphogenesisGO:00009022890.153
Mouse
neuron fate commitmentGO:0048663260.149
Mouse
canonical wnt signaling pathwayGO:0060070480.145
pancreatic d cell differentiationGO:000331120.144
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.137
digestive tract morphogenesisGO:00485462310.134
neuron differentiationGO:00301823530.132
cerebellar cortex formationGO:002169750.125
multicellular organismal signalingGO:0035637220.125
neuron projection developmentGO:00311751800.121
Mouse
negative regulation of cell fate commitmentGO:0010454130.120
organic substance biosynthetic processGO:19015762890.117
Mouse Rat
cellular protein catabolic processGO:004425740.116
heterocycle metabolic processGO:00464832900.112
Mouse Rat
cellular macromolecule biosynthetic processGO:00346452240.111
Mouse Rat
neuron fate specificationGO:0048665200.107
Mouse
response to external stimulusGO:00096052640.107
cellular component movementGO:00069283350.106
Mouse
foregut morphogenesisGO:000744040.105
locomotionGO:00400113130.104
Mouse
specification of symmetryGO:00097992040.103
Worm
extrinsic apoptotic signaling pathwayGO:009719130.102
negative regulation of response to stimulusGO:00485851040.099
agingGO:000756820.098
regulation of gliogenesisGO:001401360.096
Mouse
regulation of gene expressionGO:00104682650.095
Mouse Rat
axon ensheathment in central nervous systemGO:003229120.090
regulation of cellular biosynthetic processGO:00313262450.090
Mouse Rat
regionalizationGO:00030022740.089
Mouse
positive regulation of neuron migrationGO:200122420.085
neural tube formationGO:0001841160.081
neuronal action potentialGO:0019228180.081
cellular nitrogen compound metabolic processGO:00346412900.079
Mouse Rat
neural tube patterningGO:0021532330.079
oligodendrocyte cell fate specificationGO:002177840.077
regulation of signal transductionGO:00099662250.071
gland developmentGO:00487321430.070
stem cell proliferationGO:007208940.069
localization of cellGO:00516742440.069
Mouse
hindbrain developmentGO:0030902910.068
transcription dna templatedGO:00063511810.067
Mouse Rat
negative regulation of cell communicationGO:0010648960.066
neuron projection morphogenesisGO:00488121610.066
Mouse
head developmentGO:00603223030.064
oocyte maturationGO:000155640.063
heterocycle biosynthetic processGO:00181302150.063
Mouse Rat
positive regulation of gastrulationGO:200054320.063
action potentialGO:0001508190.063
cellular nitrogen compound biosynthetic processGO:00442712180.063
Mouse Rat
fin developmentGO:0033333770.062
anatomical structure arrangementGO:004853220.061
negative regulation of mesodermal cell fate specificationGO:004266230.060
stem cell fate commitmentGO:004886510.060
chemotaxisGO:00069351040.059
columnar cuboidal epithelial cell differentiationGO:0002065380.059
metencephalon developmentGO:0022037270.058
cellular macromolecule metabolic processGO:00442603910.058
Mouse Rat
spinal cord motor neuron cell fate specificationGO:002152080.057
Mouse
behaviorGO:0007610740.057
Worm
cell morphogenesis involved in neuron differentiationGO:00486671630.057
Mouse
gene expressionGO:00104672520.056
Mouse Rat
taxisGO:00423301090.055
multi organism processGO:00517041340.055
Worm
glial cell developmentGO:0021782200.055
spinal cord oligodendrocyte cell fate specificationGO:002153020.054
regulation of cellular metabolic processGO:00313233200.053
Mouse Rat
nitrogen compound metabolic processGO:00068073190.052
Mouse Rat
dorsal ventral axis specificationGO:0009950140.051
epithelial cell developmentGO:0002064420.051
Rat
tube morphogenesisGO:00352393490.051
epithelial cell differentiationGO:00308551160.051
neural plate pattern specificationGO:0060896120.050
embryonic skeletal joint developmentGO:007249830.049
neural plate anterior posterior regionalizationGO:002199980.048
negative regulation of signalingGO:0023057960.048
mitochondrion organizationGO:000700540.047
regulation of macromolecule metabolic processGO:00602553170.047
Mouse Rat
neuromuscular process controlling balanceGO:005088530.046
regulation of gastrulationGO:0010470240.045
rostrocaudal neural tube patterningGO:0021903290.045
neuron developmentGO:00486662620.044
Mouse
modification dependent macromolecule catabolic processGO:004363230.043
positive regulation of secretionGO:005104710.042
Rat
negative regulation of signal transductionGO:0009968940.042
regulation of cell developmentGO:00602841000.042
Mouse
organelle organizationGO:00069962270.041
proximal tubule developmentGO:007201430.041
compound eye developmentGO:004874920.041
positive regulation of cell fate commitmentGO:001045510.041
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.041
digestive system developmentGO:00551232890.041
nuclear migrationGO:000709730.040
regulation of neuron migrationGO:200122220.040
Mouse
regulation of response to nutrient levelsGO:003210710.040
hormone transportGO:000991420.040
Rat
regulation of response to stimulusGO:00485832690.040
positive regulation of map kinase activityGO:004340630.039
regulation of multicellular organismal processGO:00512392770.039
Mouse
regulation of developmental processGO:00507932470.038
Mouse
cell surface receptor signaling pathwayGO:00071663250.038
Mouse
anterior posterior pattern specificationGO:00099521520.038
regulation of nitrogen compound metabolic processGO:00511712510.038
Mouse Rat
regulation of protein catabolic processGO:004217610.038
wnt signaling pathwayGO:0016055800.038
aromatic compound biosynthetic processGO:00194382170.037
Mouse Rat
ventral spinal cord interneuron fate commitmentGO:006057930.036
Mouse
embryonic skeletal system developmentGO:0048706970.036
immune system processGO:00023762410.036
oligodendrocyte developmentGO:001400370.036
proteolysis involved in cellular protein catabolic processGO:005160330.035
modification dependent protein catabolic processGO:001994130.035
rna metabolic processGO:00160702190.035
Mouse Rat
blood vessel developmentGO:00015682460.035
phosphatidylinositol 3 kinase signalingGO:001406520.034
regulation of syncytium formation by plasma membrane fusionGO:006014220.034
regulation of biological qualityGO:00650082630.034
Mouse Rat
endocardium morphogenesisGO:000316040.034
positive regulation of transportGO:005105020.034
Rat
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:004315470.032
abducens nucleus developmentGO:002174220.032
regulation of multicellular organism growthGO:004001440.032
spinal cord patterningGO:002151160.031
Mouse
cardiac chamber formationGO:000320740.031
axial mesoderm formationGO:004832040.029
amine metabolic processGO:000930820.029
morphogenesis of an epitheliumGO:00020093330.029
positive regulation of cellular component biogenesisGO:004408930.028
embryonic skeletal joint morphogenesisGO:006027230.028
cellular component morphogenesisGO:00329893360.028
Mouse
adult behaviorGO:003053420.028
negative regulation of cellular processGO:00485232830.027
Mouse Rat
negative regulation of rna biosynthetic processGO:1902679450.026
Rat
organic cyclic compound metabolic processGO:19013603010.026
Mouse Rat
pancreatic d cell developmentGO:000332410.026
regulation of skeletal muscle tissue developmentGO:004864140.026
central nervous system neuron differentiationGO:0021953740.026
organic acid metabolic processGO:0006082310.025
multicellular organism growthGO:003526440.025
transmission of nerve impulseGO:0019226190.025
transcription from rna polymerase ii promoterGO:0006366800.025
Mouse Rat
embryonic organ developmentGO:00485683810.025
positive regulation of oligodendrocyte differentiationGO:004871410.024
cerebellar cortex developmentGO:002169550.024
negative regulation of gastrulationGO:2000542110.024
protein targeting to nucleusGO:004474430.024
regulation of cellular protein catabolic processGO:190336210.024
centrosome organizationGO:005129710.024
cerebellar cortex morphogenesisGO:002169650.023
stem cell maintenanceGO:001982740.023
spinal cord association neuron differentiationGO:002152710.023
glial cell fate specificationGO:002178040.023
proteolysisGO:0006508380.023
cartilage developmentGO:0051216960.023
regulation of carbohydrate metabolic processGO:000610940.023
proteasomal protein catabolic processGO:001049820.023
brain developmentGO:00074202930.023
endodermal cell fate determinationGO:000749320.023
cellular amino acid metabolic processGO:000652070.023
embryonic epithelial tube formationGO:0001838170.023
myelinationGO:0042552180.022
cell migrationGO:00164772370.022
Mouse
negative regulation of developmental processGO:0051093650.022
Mouse
regulation of wnt signaling pathwayGO:0030111530.022
regulation of apoptotic signaling pathwayGO:2001233120.022
positive regulation of cell cycleGO:004578730.022
regulation of reactive oxygen species metabolic processGO:200037720.021
axonogenesisGO:00074091520.021
Mouse
response to monosaccharideGO:003428430.021
regulation of apoptotic processGO:0042981980.021
primary neural tube formationGO:001402010.021
posterior lateral line system developmentGO:0048915460.021
positive regulation of cytoskeleton organizationGO:005149530.021
post embryonic foregut morphogenesisGO:004861830.020
cellular biosynthetic processGO:00442492860.020
Mouse Rat
epidermal cell fate specificationGO:000995740.020
response to biotic stimulusGO:0009607970.020
transportGO:00068102200.020
Rat
neural crest cell differentiationGO:0014033720.020
negative regulation of protein transportGO:005122430.020
negative regulation of cell developmentGO:0010721260.020
Mouse
regulation of stem cell proliferationGO:007209120.020
larval developmentGO:000216420.019
negative regulation of neural precursor cell proliferationGO:200017810.019
heart developmentGO:00075073130.019
regulation of cellular amino acid metabolic processGO:000652100.019
mesenchymal cell proliferationGO:001046310.019
embryonic organ morphogenesisGO:00485622740.019
negative regulation of multicellular organismal processGO:0051241690.019
Mouse
cellular aromatic compound metabolic processGO:00067252950.019
Mouse Rat
skeletal system morphogenesisGO:00487051020.019
regulation of transcription dna templatedGO:00063552130.018
Mouse Rat
type b pancreatic cell developmentGO:000332340.018
Rat
spinal cord motor neuron differentiationGO:0021522260.018
negative regulation of oocyte developmentGO:006028320.018
regulation of canonical wnt signaling pathway involved in neural plate anterior posterior pattern formationGO:006082730.018
negative regulation of gene expressionGO:0010629650.018
Rat
regulation of neural precursor cell proliferationGO:200017730.018
regulation of response to extracellular stimulusGO:003210410.018
liver developmentGO:0001889960.018
ectoderm formationGO:000170520.018
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.018
regulation of autophagyGO:001050630.018
gabaergic neuron differentiationGO:009715420.018
homeostasis of number of cells within a tissueGO:004887340.018
regulation of cellular macromolecule biosynthetic processGO:20001122220.018
Mouse Rat
positive regulation of catabolic processGO:000989640.018
regulation of anatomical structure morphogenesisGO:00226031300.017
Mouse
floor plate developmentGO:0033504150.017
muscle cell differentiationGO:00426921390.017
regulation of cell communicationGO:00106462320.017
Rat
negative regulation of wnt signaling pathwayGO:0030178300.017
cellular ketone metabolic processGO:0042180110.017
fourth ventricle developmentGO:002159280.016
oxoacid metabolic processGO:0043436310.016
nucleobase containing compound biosynthetic processGO:00346542050.016
Mouse Rat
midbrain hindbrain boundary morphogenesisGO:002155550.016
growthGO:00400071740.016
Mouse
rna biosynthetic processGO:00327741810.016
Mouse Rat
positive regulation of cellular amino acid metabolic processGO:004576400.016
programmed cell deathGO:00125011190.016
blood vessel morphogenesisGO:00485142160.016
epiboly involved in gastrulation with mouth forming secondGO:0055113350.016
actin filament based processGO:0030029640.016
positive regulation of metabolic processGO:00098931080.015
cellular amide metabolic processGO:004360340.015
pancreatic a cell differentiationGO:000331060.015
positive regulation of nervous system developmentGO:0051962250.015
Mouse
positive regulation of epithelial cell proliferationGO:005067910.015
somatic muscle developmentGO:000752540.015
regulation of cell fate commitmentGO:0010453220.015
striated muscle cell differentiationGO:00511461290.015
signal transductionGO:00071654550.015
Mouse
central nervous system myelin formationGO:003228910.015
deathGO:00162651210.015
trigeminal nerve developmentGO:002155930.015
regulation of proteolysisGO:0030162240.015
autonomic nervous system developmentGO:0048483190.015
digestive tract developmentGO:00485652650.015
glial cell differentiationGO:0010001420.015
Mouse
dorsal ventral neural tube patterningGO:002190410.015
endodermal digestive tract morphogenesisGO:006103120.015
negative regulation of cellular biosynthetic processGO:0031327550.015
Rat
regulation of extrinsic apoptotic signaling pathwayGO:200123630.015
epibolyGO:0090504410.015
dna biosynthetic processGO:007189730.014
embryonic foregut morphogenesisGO:004861710.014
regulation of cardiac chamber formationGO:190121020.014
response to other organismGO:0051707970.014
l amino acid transportGO:001580710.014
immunoglobulin mediated immune responseGO:001606430.014
positive regulation of signal transductionGO:0009967560.014
immune system developmentGO:00025201910.014
cellular component assemblyGO:00226071700.014
reproductive structure developmentGO:004860850.014
Worm
immune responseGO:0006955280.014
nucleic acid templated transcriptionGO:00976591810.014
Mouse Rat
heart loopingGO:0001947940.014
regulation of calcium mediated signalingGO:005084810.014
neuroblast differentiationGO:001401610.014
hepaticobiliary system developmentGO:0061008980.014
cognitionGO:005089010.014
protein metabolic processGO:00195381830.014
germ line stem cell maintenanceGO:003071820.014
muscle structure developmentGO:00610611960.014
regulation of locomotionGO:0040012550.014
Mouse
protein importGO:001703830.014
nephron tubule epithelial cell differentiationGO:007216010.014
protein stabilizationGO:005082120.014
epithelial tube morphogenesisGO:00605621480.014
pituitary gland developmentGO:0021983160.014
negative regulation of signal transduction in absence of ligandGO:190109910.013
centrosome duplicationGO:005129810.013
carboxylic acid transportGO:004694280.013
regulation of rna biosynthetic processGO:20011412130.013
Mouse Rat
enzyme linked receptor protein signaling pathwayGO:00071671060.013
determination of heart left right asymmetryGO:00613711170.013
positive regulation of dna metabolic processGO:005105410.013
collagen metabolic processGO:003296320.013
gamma aminobutyric acid signaling pathwayGO:000721410.013
endocrine system developmentGO:0035270650.013
neural tube developmentGO:0021915620.013
neurological system processGO:0050877620.013
positive regulation of neurogenesisGO:0050769240.013
Mouse
single organism localizationGO:19025782250.013
Rat
organ regenerationGO:003110010.013
positive regulation of secretion by cellGO:190353210.013
Rat
sensory organ developmentGO:00074233930.012
glucose importGO:004632320.012
ubiquitin dependent protein catabolic processGO:000651130.012
neuroblast proliferationGO:000740520.012
centrosome cycleGO:000709810.012
response to amino acidGO:004320020.012
regulation of protein maturationGO:1903317100.012
neural precursor cell proliferationGO:0061351200.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
mesodermal cell fate specificationGO:0007501120.012
glial cell fate determinationGO:000740310.012
stem cell divisionGO:001714510.012
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.012
positive regulation of embryonic developmentGO:004001930.012
periodic partitioningGO:000736510.012
anterior commissure morphogenesisGO:002196030.012
tissue homeostasisGO:0001894250.011
angiogenesisGO:00015251580.011
axial mesodermal cell fate specificationGO:004832730.011
positive regulation of stem cell proliferationGO:200064810.011
pigmentationGO:0043473850.011
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.011
striated muscle cell developmentGO:00550021080.011
motor neuron axon guidanceGO:0008045230.011
single organism nuclear importGO:190259330.011
system processGO:00030081850.011
regulation of neurological system processGO:003164420.011
signal transduction in absence of ligandGO:003803410.011
carboxylic acid catabolic processGO:004639530.011
anatomical structure homeostasisGO:0060249360.011
epithelial cell morphogenesis involved in gastrulationGO:000338110.011
cell cycle g1 s phase transitionGO:004484310.011
negative regulation of reproductive processGO:200024230.011
cellular response to oxygen containing compoundGO:1901701200.011
Rat
small molecule catabolic processGO:004428230.011
negative regulation of multi organism processGO:004390130.011
wnt signaling pathway involved in somitogenesisGO:009024420.011
positive regulation of muscle tissue developmentGO:190186310.011
neuroblast fate commitmentGO:001401710.011
skeletal system developmentGO:00015011810.011
regulation of myelinationGO:003164110.011
lateral line system developmentGO:0048925760.011
regulation of nervous system developmentGO:0051960900.011
Mouse
regulation of cell activationGO:005086510.011
negative regulation of defense responseGO:003134820.011
regulation of glucose importGO:004632410.011
glial cell fate commitmentGO:002178160.011
establishment of localizationGO:00512342440.010
Rat
regulation of programmed cell deathGO:00430671010.010
medial fin morphogenesisGO:0035141140.010
forebrain anterior posterior pattern specificationGO:002179730.010
growth plate cartilage developmentGO:000341720.010
positive regulation of translationGO:004572710.010
humoral immune response mediated by circulating immunoglobulinGO:000245530.010
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.010
regulation of endopeptidase activityGO:0052548230.010
gastrulationGO:00073692080.010
neurotransmitter transportGO:000683620.010
cellular response to chemical stimulusGO:00708871570.010
Rat
embryonic digestive tract developmentGO:004856640.010
autophagyGO:000691440.010
regulation of protein transportGO:005122330.010
striated muscle tissue developmentGO:00147061100.010
regulation of erythrocyte differentiationGO:004564620.010

nkx6.1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.034
disease of anatomical entityDOID:700.033
organ system cancerDOID:005068600.030
cancerDOID:16200.030
disease of cellular proliferationDOID:1456600.030
electroclinical syndromeDOID:005070100.015
nervous system diseaseDOID:86300.015
brain diseaseDOID:93600.015
central nervous system diseaseDOID:33100.015
epilepsy syndromeDOID:182600.015
type 2 diabetes mellitusDOID:935200.014
carbohydrate metabolism diseaseDOID:005001300.014
glucose metabolism diseaseDOID:419400.014
diabetes mellitusDOID:935100.014
acquired metabolic diseaseDOID:006015800.014
sensory system diseaseDOID:005015500.011
auditory system diseaseDOID:274200.011