Danio rerio

76 known processes

crb2b

crumbs homolog 2b

(Aliases: crb2l)

crb2b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
apical protein localizationGO:004517660.799
Zebrafish
cilium morphogenesisGO:0060271850.591
signal transductionGO:00071654550.516
Zebrafish
cilium assemblyGO:0042384580.297
neuron differentiationGO:00301823530.255
wnt signaling pathwayGO:0016055800.248
Zebrafish
response to drugGO:004249330.205
phototransductionGO:000760220.203
nephron developmentGO:0072006310.196
neurological system processGO:0050877620.191
establishment or maintenance of apical basal cell polarityGO:0035088120.191
cellular response to radiationGO:007147840.191
g protein coupled receptor signaling pathwayGO:0007186740.186
regulation of metabolic processGO:00192223590.181
detection of visible lightGO:0009584120.178
single organism transportGO:00447652060.170
cilium organizationGO:0044782710.161
dorsal motor nucleus of vagus nerve developmentGO:002174440.160
eye photoreceptor cell developmentGO:0042462300.151
brain developmentGO:00074202930.147
Zebrafish
negative regulation of signalingGO:0023057960.143
Zebrafish
regulation of biological qualityGO:00650082630.141
heterophilic cell cell adhesion via plasma membrane cell adhesion moleculesGO:000715720.137
regulation of cell communicationGO:00106462320.134
Zebrafish
system processGO:00030081850.134
cellular component biogenesisGO:00440851780.129
visual perceptionGO:0007601170.127
sensory organ developmentGO:00074233930.126
cell morphogenesisGO:00009022890.117
cell projection organizationGO:00300302840.116
cell substrate adhesionGO:003158940.116
cell adhesionGO:0007155400.114
cell projection morphogenesisGO:00488582440.109
single organism organelle organizationGO:19025891990.106
morphogenesis of an epitheliumGO:00020093330.099
negative regulation of biological processGO:00485193040.099
Zebrafish
smoothened signaling pathwayGO:0007224300.096
neuron developmentGO:00486662620.096
response to radiationGO:0009314510.094
regulation of wnt signaling pathwayGO:0030111530.091
Zebrafish
glomerular filtrationGO:000309460.090
photoreceptor cell differentiationGO:0046530550.089
kidney developmentGO:0001822920.085
regulation of metal ion transportGO:001095940.082
regulation of signalingGO:00230512350.082
Zebrafish
regulation of cyclic nucleotide metabolic processGO:0030799150.081
muscle structure developmentGO:00610611960.081
retina morphogenesis in camera type eyeGO:0060042790.080
negative regulation of response to stimulusGO:00485851040.079
Zebrafish
cell matrix adhesionGO:000716040.078
adherens junction organizationGO:003433240.076
pronephros developmentGO:0048793690.076
medulla oblongata developmentGO:002155040.075
cellular macromolecule metabolic processGO:00442603910.074
response to abiotic stimulusGO:00096281220.074
single organismal cell cell adhesionGO:0016337290.072
response to light stimulusGO:0009416460.070
biological adhesionGO:0022610400.066
eye developmentGO:00016542770.066
cell substrate adherens junction assemblyGO:000704510.066
detection of light stimulusGO:0009583120.063
organonitrogen compound metabolic processGO:1901564740.062
neural nucleus developmentGO:0048857150.062
positive regulation of cell substrate adhesionGO:001081110.062
cellular component assemblyGO:00226071700.059
angiogenesisGO:00015251580.059
retina development in camera type eyeGO:00600411460.058
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.058
cell surface receptor signaling pathwayGO:00071663250.058
Zebrafish
cell cell adhesionGO:009860960.056
cellular nitrogen compound metabolic processGO:00346412900.056
generation of neuronsGO:00486993850.055
positive regulation of cell matrix adhesionGO:000195410.054
central nervous system developmentGO:00074173870.053
Zebrafish
entrainment of circadian clock by photoperiodGO:004315310.053
cellular response to light stimulusGO:007148240.053
multicellular organism growthGO:003526440.053
cellular component assembly involved in morphogenesisGO:00109271070.052
monovalent inorganic cation transportGO:0015672420.052
regulation of calcium ion transportGO:005192420.050
heterocycle biosynthetic processGO:00181302150.050
adult behaviorGO:003053420.050
regulation of bindingGO:005109830.050
vasculature developmentGO:00019442780.049
regulation of canonical wnt signaling pathwayGO:0060828340.049
Zebrafish
renal system developmentGO:0072001940.048
positive regulation of cellular processGO:00485222010.048
regulation of stem cell differentiationGO:200073640.048
positive regulation of cellular component biogenesisGO:004408930.047
small molecule metabolic processGO:0044281770.047
positive regulation of cell adhesionGO:004578510.046
positive regulation of epithelial cell migrationGO:001063420.046
regulation of response to stimulusGO:00485832690.046
Zebrafish
cell substrate junction assemblyGO:000704420.046
negative regulation of signal transductionGO:0009968940.046
Zebrafish
tube morphogenesisGO:00352393490.046
epiboly involved in gastrulation with mouth forming secondGO:0055113350.045
phototransduction visible lightGO:000760320.045
agingGO:000756820.045
regulation of localizationGO:00328791040.044
multicellular organismal signalingGO:0035637220.044
maintenance of locationGO:005123540.044
head developmentGO:00603223030.044
Zebrafish
glomerulus developmentGO:0032835270.044
photoperiodismGO:0009648110.043
regulation of cellular amine metabolic processGO:003323800.042
negative regulation of cellular processGO:00485232830.042
Zebrafish
eye morphogenesisGO:00485921440.042
negative regulation of cell communicationGO:0010648960.042
Zebrafish
cellular protein modification processGO:00064641000.042
metal ion transportGO:0030001580.041
macromolecule modificationGO:00434121110.041
organelle organizationGO:00069962270.041
protein modification processGO:00362111000.041
sodium ion transportGO:0006814240.040
regulation of neurotransmitter transportGO:005158810.040
epibolyGO:0090504410.040
regulation of tube sizeGO:003515020.040
chordate embryonic developmentGO:00430092710.040
cgmp metabolic processGO:004606870.040
ion transportGO:00068111140.039
determination of left right symmetryGO:00073681790.039
protein metabolic processGO:00195381830.039
renal filtrationGO:0097205100.039
establishment of localizationGO:00512342440.038
regulation of establishment of protein localizationGO:007020140.038
regulation of cgmp biosynthetic processGO:003082660.038
cellular component movementGO:00069283350.037
positive regulation of transportGO:005105020.037
circadian regulation of gene expressionGO:003292280.037
digestive tract morphogenesisGO:00485462310.037
ear developmentGO:00435831270.036
regulation of signal transductionGO:00099662250.036
Zebrafish
cellular nitrogen compound biosynthetic processGO:00442712180.036
muscle cell developmentGO:00550011150.035
negative regulation of canonical wnt signaling pathwayGO:0090090210.035
Zebrafish
positive regulation of biological processGO:00485182530.035
muscle cell differentiationGO:00426921390.035
camera type eye developmentGO:00430102220.034
cellular biosynthetic processGO:00442492860.034
regulation of mrna processingGO:005068430.034
regulation of phGO:000688530.033
phosphorus metabolic processGO:00067931090.033
cell projection assemblyGO:0030031640.033
multicellular organismal homeostasisGO:0048871290.033
regulation of sodium ion transportGO:000202820.033
regulation of circadian rhythmGO:004275240.033
hindbrain developmentGO:0030902910.032
nitrogen compound metabolic processGO:00068073190.032
positive regulation of guanylate cyclase activityGO:003128460.032
regulation of macromolecule metabolic processGO:00602553170.032
neuronal action potentialGO:0019228180.032
gene expressionGO:00104672520.031
negative regulation of wnt signaling pathwayGO:0030178300.031
Zebrafish
digestive system developmentGO:00551232890.031
regulation of cellular amino acid metabolic processGO:000652100.031
positive regulation of protein complex assemblyGO:003133420.031
cellular response to nutrient levelsGO:003166920.031
response to chemicalGO:00422213200.030
regulation of protein complex assemblyGO:004325430.030
positive regulation of signalingGO:0023056560.030
vascular endothelial growth factor receptor signaling pathwayGO:0048010130.030
cellular response to hypoxiaGO:007145610.030
blood vessel developmentGO:00015682460.029
adherens junction assemblyGO:003433310.029
developmental growth involved in morphogenesisGO:0060560860.029
blood vessel morphogenesisGO:00485142160.029
single organism cell adhesionGO:0098602290.029
cognitionGO:005089010.029
morphogenesis of an epithelial sheetGO:0002011490.028
carbon dioxide transportGO:001567030.028
nucleobase containing compound metabolic processGO:00061392740.028
response to monosaccharideGO:003428430.027
regulation of hormone secretionGO:004688320.027
cation transmembrane transportGO:0098655650.027
cellular response to oxygen levelsGO:007145310.027
regulation of peptidyl tyrosine phosphorylationGO:005073010.027
regulation of lyase activityGO:0051339120.027
sodium ion transmembrane transportGO:0035725210.026
regulation of nitrogen compound metabolic processGO:00511712510.026
embryonic heart tube developmentGO:00350501330.026
camera type eye morphogenesisGO:00485931080.026
regulation of blood vessel sizeGO:005088020.026
regulation of extrinsic apoptotic signaling pathwayGO:200123630.026
regulation of cellular metabolic processGO:00313233200.026
tissue homeostasisGO:0001894250.026
developmental programmed cell deathGO:001062340.026
cation transportGO:0006812810.026
sensory perception of light stimulusGO:0050953190.026
blood circulationGO:0008015870.025
positive regulation of cell cycleGO:004578730.025
cellular component morphogenesisGO:00329893360.025
regulation of sequestering of calcium ionGO:005128240.025
microtubule organizing center organizationGO:003102310.025
inner ear developmentGO:00488391260.025
locomotor rhythmGO:004547530.025
sensory organ morphogenesisGO:00905962000.025
negative regulation of kinase activityGO:003367340.024
amine metabolic processGO:000930820.024
notch signaling pathwayGO:0007219350.024
Zebrafish
protein importGO:001703830.024
determination of bilateral symmetryGO:00098552040.024
aromatic compound biosynthetic processGO:00194382170.024
response to alkaloidGO:004327920.023
cellular amine metabolic processGO:004410620.023
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.023
gas transportGO:001566930.023
actin polymerization or depolymerizationGO:000815420.023
biosynthetic processGO:00090582940.023
cellular amino acid metabolic processGO:000652070.023
regulation of guanylate cyclase activityGO:003128260.023
regulation of anatomical structure morphogenesisGO:00226031300.023
regulation of ion transmembrane transporter activityGO:003241220.023
regulation of membrane potentialGO:0042391230.023
regulation of neurotransmitter secretionGO:004692810.022
gastrulationGO:00073692080.022
cellular component maintenanceGO:004395430.022
neural tube formationGO:0001841160.022
response to hexoseGO:000974630.022
rhythmic processGO:0048511210.022
protein polymerizationGO:005125840.022
sprouting angiogenesisGO:0002040530.021
positive regulation of cgmp biosynthetic processGO:003082860.021
detection of stimulusGO:0051606290.021
positive regulation of response to stimulusGO:0048584800.021
positive regulation of map kinase activityGO:004340630.021
establishment of endothelial barrierGO:006102830.021
transportGO:00068102200.021
cellular protein metabolic processGO:00442671290.021
synaptic transmission cholinergicGO:000727140.021
epithelial cell morphogenesisGO:000338220.020
polarized epithelial cell differentiationGO:003085940.020
programmed cell deathGO:00125011190.020
inorganic cation transmembrane transportGO:0098662500.020
spermatid developmentGO:000728620.020
behaviorGO:0007610740.020
sequestering of metal ionGO:005123830.020
embryonic retina morphogenesis in camera type eyeGO:0060059220.020
Zebrafish
long chain fatty acid metabolic processGO:000167610.020
mitotic cell cycle processGO:1903047480.020
ion transmembrane transportGO:0034220910.020
cell cell adhesion via plasma membrane adhesion moleculesGO:009874260.020
regulation of endothelial cell proliferationGO:000193610.019
response to amphetamineGO:000197510.019
cellular localizationGO:0051641970.019
response to carbohydrateGO:000974330.019
cellular response to decreased oxygen levelsGO:003629410.019
regulation of transmembrane transporter activityGO:002289820.019
bicarbonate transportGO:001570140.019
extrinsic apoptotic signaling pathwayGO:009719130.019
transmission of nerve impulseGO:0019226190.019
peptidyl serine phosphorylationGO:001810510.019
circadian rhythmGO:0007623190.019
response to uvGO:000941130.018
meiotic nuclear divisionGO:000712640.018
nuclear transportGO:005116940.018
establishment of protein localization to organelleGO:007259440.018
regulation of multicellular organismal processGO:00512392770.018
regulation of cell matrix adhesionGO:000195210.018
establishment or maintenance of polarity of embryonic epitheliumGO:001633220.018
response to hydrogen peroxideGO:004254230.018
regulation of cellular ketone metabolic processGO:001056570.018
regulation of cell substrate adhesionGO:001081010.018
regulation of multicellular organism growthGO:004001440.018
regulation of blood pressureGO:000821710.018
circadian sleep wake cycle processGO:002241020.018
cellular response to chemical stimulusGO:00708871570.018
response to amineGO:001407510.018
phosphorylationGO:0016310690.017
hormone transportGO:000991420.017
gastrulation with mouth forming secondGO:0001702440.017
heterocycle metabolic processGO:00464832900.017
immune system developmentGO:00025201910.017
apoptotic processGO:00069151160.017
post embryonic organ developmentGO:004856940.017
hair cell differentiationGO:0035315320.017
detection of abiotic stimulusGO:0009582240.017
centrosome organizationGO:005129710.017
digestive tract developmentGO:00485652650.017
actin mediated cell contractionGO:007025210.017
sleepGO:003043110.017
nucleocytoplasmic transportGO:000691340.017
light induced release of internally sequestered calcium ionGO:000837710.017
organelle assemblyGO:00709251100.017
histone modificationGO:0016570200.017
response to foodGO:003209410.017
mechanoreceptor differentiationGO:0042490370.016
carboxylic acid metabolic processGO:0019752220.016
astrocyte differentiationGO:004870810.016
regulation of cell cell adhesionGO:0022407130.016
cellular response to external stimulusGO:007149620.016
rho protein signal transductionGO:000726650.016
regulation of gene expressionGO:00104682650.016
regulation of cellular component movementGO:0051270550.016
response to glucoseGO:000974930.016
stem cell proliferationGO:007208940.016
guanosine containing compound catabolic processGO:190106920.016
regulation of chemotaxisGO:0050920180.016
protein secretionGO:000930610.016
homeostasis of number of cells within a tissueGO:004887340.016
regulation of organelle assemblyGO:190211540.015
axon ensheathmentGO:0008366180.015
transmembrane transportGO:00550851200.015
regulation of cell motilityGO:2000145460.015
positive regulation of cell divisionGO:005178120.015
positive regulation of cytoskeleton organizationGO:005149530.015
rna metabolic processGO:00160702190.015
regulation of cellular macromolecule biosynthetic processGO:20001122220.015
regulation of protein transportGO:005122330.015
single organism metabolic processGO:00447102170.015
regulation of nucleic acid templated transcriptionGO:19035062130.015
positive regulation of catabolic processGO:000989640.015
epithelial cell developmentGO:0002064420.015
embryonic limb morphogenesisGO:003032620.015
proteasomal protein catabolic processGO:001049820.015
cellular component disassemblyGO:002241110.015
proximal tubule developmentGO:007201430.015
regulation of multicellular organismal developmentGO:20000262230.015
response to inorganic substanceGO:0010035380.015
cellular aromatic compound metabolic processGO:00067252950.015
response to organic substanceGO:00100331530.015
protein localization to plasma membraneGO:007265910.015
purine nucleotide biosynthetic processGO:0006164200.015
peptidyl lysine acetylationGO:001839420.015
sensory perceptionGO:0007600390.015
regulation of rho protein signal transductionGO:003502320.015
nucleic acid metabolic processGO:00903042440.015
myelination in peripheral nervous systemGO:002201140.014
rhodopsin mediated signaling pathwayGO:001605610.014
calcium mediated signalingGO:001972220.014
oxoacid metabolic processGO:0043436310.014
macromolecule biosynthetic processGO:00090592270.014
immune system processGO:00023762410.014
regulation of locomotionGO:0040012550.014
regulation of epithelial cell proliferationGO:005067830.014
phagocytosisGO:000690930.014
action potentialGO:0001508190.014
one carbon compound transportGO:0019755140.014
neuroblast proliferationGO:000740520.014
negative regulation of protein phosphorylationGO:000193340.014
response to growth factorGO:0070848390.014
response to external stimulusGO:00096052640.014
regulation of biosynthetic processGO:00098892500.014
negative regulation of protein kinase activityGO:000646940.014
single organism nuclear importGO:190259330.014
regulation of circadian sleep wake cycle sleepGO:004518710.014
rna biosynthetic processGO:00327741810.014
positive regulation of cellular catabolic processGO:003133130.014
protein complex localizationGO:003150310.014
cell growthGO:0016049570.014
negative regulation of secretion by cellGO:190353120.014
neuron neuron synaptic transmissionGO:000727010.014
regulation of transporter activityGO:003240920.014
stem cell divisionGO:001714510.014
deathGO:00162651210.014
regulation of angiogenesisGO:0045765260.014
regulation of carbohydrate metabolic processGO:000610940.014
microtubule based movementGO:0007018330.013
response to light intensityGO:000964210.013
regulation of reproductive processGO:200024140.013
regulation of sodium ion transmembrane transporter activityGO:200064910.013
nuclear migrationGO:000709730.013
single organism localizationGO:19025782250.013
positive regulation of endothelial cell proliferationGO:000193810.013
regulation of epithelial to mesenchymal transitionGO:001071730.013
embryo development ending in birth or egg hatchingGO:00097922710.013
regulation of cgmp metabolic processGO:003082360.013
urogenital system developmentGO:0001655970.013
carbohydrate homeostasisGO:003350010.013
cellular response to starvationGO:000926710.013
cellular response to extracellular stimulusGO:003166820.013
cell morphogenesis involved in differentiationGO:00009041950.013
cellular ketone metabolic processGO:0042180110.013
larval developmentGO:000216420.013
regulation of cell deathGO:00109411030.013
regulation of meiotic cell cycleGO:005144510.013
single organism biosynthetic processGO:0044711710.013
cellular macromolecule biosynthetic processGO:00346452240.013
monoamine transportGO:001584410.013
response to unfolded proteinGO:000698620.013
regulation of jun kinase activityGO:004350630.013
regulation of protein metabolic processGO:0051246560.013
cell part morphogenesisGO:00329902460.013
organic substance biosynthetic processGO:19015762890.012
absorption of visible lightGO:001603820.012
regulation of cell activationGO:005086510.012
regulation of cell migrationGO:0030334400.012
organic cyclic compound metabolic processGO:19013603010.012
regulation of cytokine productionGO:000181730.012
cell deathGO:00082191210.012
regulation of nucleobase containing compound metabolic processGO:00192192500.012
regulation of response to nutrient levelsGO:003210710.012
negative regulation of protein transportGO:005122430.012
schwann cell differentiationGO:001403790.012
establishment of epithelial cell polarityGO:009016220.012
localization of cellGO:00516742440.012
cyclic nucleotide metabolic processGO:0009187180.012
ameboidal type cell migrationGO:00016671430.012
neurotransmitter secretionGO:000726920.012
regulation of rna metabolic processGO:00512522240.012
regulation of developmental processGO:00507932470.012
regulation of primary metabolic processGO:00800903110.012
response to corticosteroidGO:003196010.012
glial cell differentiationGO:0010001420.012
regulation of cell projection organizationGO:0031344440.012
protein targeting to nucleusGO:004474430.012
fatty acid biosynthetic processGO:000663340.012
intracellular signal transductionGO:0035556850.012
actin filament polymerizationGO:003004120.012
regulation of protein bindingGO:004339330.012
positive regulation of secretion by cellGO:190353210.012
regulation of cellular biosynthetic processGO:00313262450.012
development of primary female sexual characteristicsGO:004654540.012
cell motilityGO:00488702440.012
regulation of macromolecule biosynthetic processGO:00105562250.012
response to topologically incorrect proteinGO:003596620.011
regulation of protein localization to plasma membraneGO:190307610.011
establishment of synaptic vesicle localizationGO:009748010.011
mononuclear cell proliferationGO:003294310.011
negative regulation of mapk cascadeGO:004340940.011
skin developmentGO:0043588540.011
axon developmentGO:00615641660.011
regulation of cell adhesionGO:0030155150.011
cytokinesisGO:000091030.011
photoreceptor cell fate commitmentGO:004655210.011
nuclear importGO:005117030.011
activation of mapk activityGO:000018730.011
positive regulation of secretionGO:005104710.011
inorganic ion transmembrane transportGO:0098660570.011
glucose importGO:004632320.011
chemotaxisGO:00069351040.011
maintenance of epithelial cell apical basal polarityGO:004519950.011
receptor internalizationGO:003162320.011
cell death in response to oxidative stressGO:003647320.011
cellular response to vascular endothelial growth factor stimulusGO:003592430.011
sensory perception of chemical stimulusGO:000760630.011
regulation of sodium ion transmembrane transportGO:190230510.011
regulation of protein polymerizationGO:003227120.011
phosphate containing compound metabolic processGO:00067961080.011
regulation of cell projection assemblyGO:006049140.011
sulfate transportGO:000827220.011
gtp catabolic processGO:000618420.011
regulation of vasculature developmentGO:1901342330.011
regulation of nucleocytoplasmic transportGO:004682220.011
regulation of cyclase activityGO:0031279120.011
response to glucocorticoidGO:005138410.011
locomotionGO:00400113130.011
nucleobase containing compound biosynthetic processGO:00346542050.011
autophagyGO:000691440.011
macromolecular complex subunit organizationGO:0043933740.011
regulation of inflammatory responseGO:005072720.011
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.011
positive regulation of endothelial cell migrationGO:001059520.011
establishment of epithelial cell apical basal polarityGO:004519820.011
regulation of dendrite morphogenesisGO:004881430.011
small gtpase mediated signal transductionGO:000726480.010
peptidyl serine modificationGO:001820920.010
organonitrogen compound biosynthetic processGO:1901566470.010
positive regulation of glucose transportGO:001082810.010
regulation of mrna splicing via spliceosomeGO:004802430.010
glial cell developmentGO:0021782200.010
sequestering of calcium ionGO:005120830.010
response to vitaminGO:003327330.010
regulation of cytoplasmic transportGO:190364940.010
glial cell proliferationGO:001400940.010
neurotransmitter transportGO:000683620.010
cellular protein complex disassemblyGO:004362410.010
response to nicotineGO:003509420.010
cellular response to stressGO:0033554620.010
lymph vessel developmentGO:0001945270.010
spermatid differentiationGO:004851520.010
neuron projection extensionGO:1990138450.010
positive regulation of multi organism processGO:004390230.010
regulation of notch signaling pathwayGO:0008593160.010
Zebrafish
hematopoietic or lymphoid organ developmentGO:00485341910.010
regulation of rho gtpase activityGO:003231910.010
somite rostral caudal axis specificationGO:003252550.010

crb2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
nervous system diseaseDOID:86300.077
disease of anatomical entityDOID:700.077
eye and adnexa diseaseDOID:149200.059
sensory system diseaseDOID:005015500.059
eye diseaseDOID:561400.035
retinal diseaseDOID:567900.032
retinal degenerationDOID:846600.016
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
musculoskeletal system diseaseDOID:1700.013
retinitis pigmentosaDOID:1058400.012