Danio rerio

0 known processes

plekhg4

pleckstrin homology domain containing, family G (with RhoGef domain) member 4

(Aliases: wu:fd99e06)

plekhg4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
endothelial cell fate commitmentGO:006083930.734
regulation of transcription from rna polymerase iii promoterGO:000635910.548
lymphatic endothelial cell fate commitmentGO:006083810.540
sensory organ developmentGO:00074233930.515
cellular biosynthetic processGO:00442492860.502
signal transductionGO:00071654550.448
biosynthetic processGO:00090582940.438
digestive system developmentGO:00551232890.432
transcription from rna polymerase iii promoterGO:000638310.421
nitrogen compound metabolic processGO:00068073190.419
regulation of cellular macromolecule biosynthetic processGO:20001122220.393
intracellular receptor signaling pathwayGO:0030522300.357
head developmentGO:00603223030.334
regulation of rna metabolic processGO:00512522240.329
organic cyclic compound biosynthetic processGO:19013622230.313
central nervous system developmentGO:00074173870.306
heterocycle biosynthetic processGO:00181302150.290
lymph vessel developmentGO:0001945270.272
lymphangiogenesisGO:0001946250.271
regulation of fatty acid metabolic processGO:001921710.264
establishment of localizationGO:00512342440.250
generation of neuronsGO:00486993850.246
regulation of transcription dna templatedGO:00063552130.240
ear developmentGO:00435831270.234
gene expressionGO:00104672520.229
lymphatic endothelial cell differentiationGO:006083610.223
negative regulation of cellular biosynthetic processGO:0031327550.216
negative regulation of gene expressionGO:0010629650.211
cellular nitrogen compound metabolic processGO:00346412900.209
lymph vessel morphogenesisGO:0036303250.209
regulation of metabolic processGO:00192223590.199
camera type eye developmentGO:00430102220.193
regulation of nucleic acid templated transcriptionGO:19035062130.191
regulation of gene expressionGO:00104682650.190
cell surface receptor signaling pathwayGO:00071663250.190
lipid storageGO:001991510.188
negative regulation of nucleobase containing compound metabolic processGO:0045934590.181
regulation of response to stimulusGO:00485832690.176
negative regulation of biosynthetic processGO:0009890550.172
negative regulation of cell communicationGO:0010648960.168
aromatic compound biosynthetic processGO:00194382170.168
epithelial cell differentiationGO:00308551160.165
larval developmentGO:000216420.164
regulation of macromolecule biosynthetic processGO:00105562250.157
nucleic acid templated transcriptionGO:00976591810.152
positive regulation of biological processGO:00485182530.149
negative regulation of cellular processGO:00485232830.147
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.146
kidney developmentGO:0001822920.146
regulation of primary metabolic processGO:00800903110.141
rna biosynthetic processGO:00327741810.140
organic substance biosynthetic processGO:19015762890.138
neuron developmentGO:00486662620.137
skeletal muscle tissue developmentGO:0007519670.136
negative regulation of rna metabolic processGO:0051253480.135
nucleic acid metabolic processGO:00903042440.133
regulation of macromolecule metabolic processGO:00602553170.132
transcription dna templatedGO:00063511810.132
stem cell proliferationGO:007208940.131
regulation of signalingGO:00230512350.130
morphogenesis of an epitheliumGO:00020093330.126
regulation of nucleobase containing compound metabolic processGO:00192192500.124
neural tube developmentGO:0021915620.121
cellular nitrogen compound biosynthetic processGO:00442712180.121
response to organic substanceGO:00100331530.114
negative regulation of metabolic processGO:0009892860.113
cell deathGO:00082191210.110
rna metabolic processGO:00160702190.110
heterocycle metabolic processGO:00464832900.106
macromolecule biosynthetic processGO:00090592270.106
axon ensheathment in central nervous systemGO:003229120.105
negative regulation of cellular metabolic processGO:0031324770.103
negative regulation of blood vessel endothelial cell migrationGO:004353710.101
inner ear developmentGO:00488391260.101
regulation of cellular biosynthetic processGO:00313262450.097
neuroblast proliferationGO:000740520.097
single organism localizationGO:19025782250.097
axonogenesisGO:00074091520.096
neural tube formationGO:0001841160.095
brain developmentGO:00074202930.094
notochord developmentGO:0030903540.093
regulation of biosynthetic processGO:00098892500.092
negative regulation of nitrogen compound metabolic processGO:0051172590.090
eye developmentGO:00016542770.089
positive regulation of transportGO:005105020.089
negative regulation of signal transductionGO:0009968940.087
positive regulation of gene expressionGO:0010628710.086
cellular aromatic compound metabolic processGO:00067252950.086
neuron differentiationGO:00301823530.086
negative regulation of signalingGO:0023057960.085
ear morphogenesisGO:0042471640.085
positive regulation of cellular processGO:00485222010.085
nucleobase containing compound biosynthetic processGO:00346542050.084
embryonic organ developmentGO:00485683810.083
notch signaling pathwayGO:0007219350.083
negative regulation of biological processGO:00485193040.082
transportGO:00068102200.082
negative regulation of nucleic acid templated transcriptionGO:1903507450.081
forebrain developmentGO:0030900960.081
regulation of biological qualityGO:00650082630.081
regulation of signal transductionGO:00099662250.080
negative regulation of transcription dna templatedGO:0045892450.080
response to stressGO:00069502630.079
biological adhesionGO:0022610400.079
positive regulation of rna biosynthetic processGO:1902680570.075
negative regulation of macromolecule biosynthetic processGO:0010558480.075
cellular macromolecule biosynthetic processGO:00346452240.075
localization of cellGO:00516742440.074
neuron projection developmentGO:00311751800.074
negative regulation of macromolecule metabolic processGO:0010605760.074
regulation of apoptotic processGO:0042981980.073
erk1 and erk2 cascadeGO:007037140.073
organic cyclic compound metabolic processGO:19013603010.073
organelle organizationGO:00069962270.072
cellular macromolecule metabolic processGO:00442603910.071
sensory organ morphogenesisGO:00905962000.071
gland developmentGO:00487321430.071
cellular component morphogenesisGO:00329893360.071
response to chemicalGO:00422213200.070
digestive tract developmentGO:00485652650.070
regulation of developmental processGO:00507932470.069
regulation of cell communicationGO:00106462320.068
transcription from rna polymerase ii promoterGO:0006366800.066
negative regulation of rna biosynthetic processGO:1902679450.066
somitogenesisGO:0001756870.066
tube morphogenesisGO:00352393490.065
regulation of skeletal muscle fiber developmentGO:004874220.064
cell fate commitmentGO:0045165990.064
regulation of skeletal muscle tissue developmentGO:004864140.064
appendage developmentGO:0048736800.064
cellular response to oxygen levelsGO:007145310.063
carboxylic acid metabolic processGO:0019752220.063
nucleobase containing compound metabolic processGO:00061392740.062
somite developmentGO:0061053960.062
stem cell maintenanceGO:001982740.061
blood vessel developmentGO:00015682460.061
protein import into nucleusGO:000660630.061
lateral line system developmentGO:0048925760.061
oxoacid metabolic processGO:0043436310.060
cellular response to xenobiotic stimulusGO:0071466350.059
regulation of cellular ketone metabolic processGO:001056570.058
gastrulationGO:00073692080.058
response to external stimulusGO:00096052640.058
sensory system developmentGO:0048880760.058
primary neural tube formationGO:001402010.057
regulation of cellular metabolic processGO:00313233200.057
organic acid metabolic processGO:0006082310.057
detection of temperature stimulus involved in sensory perceptionGO:005096100.057
regulation of establishment of protein localizationGO:007020140.057
cellular component biogenesisGO:00440851780.057
response to lipidGO:0033993600.056
muscle structure developmentGO:00610611960.056
maintenance of locationGO:005123540.055
embryo development ending in birth or egg hatchingGO:00097922710.055
cellular component assemblyGO:00226071700.054
regulation of nitrogen compound metabolic processGO:00511712510.054
cytoskeleton organizationGO:0007010960.054
regulation of chemotaxisGO:0050920180.053
cellular response to chemical stimulusGO:00708871570.053
gliogenesisGO:0042063450.053
single organism metabolic processGO:00447102170.052
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.051
regulation of multicellular organismal processGO:00512392770.051
digestive tract morphogenesisGO:00485462310.051
proximal distal pattern formationGO:000995410.051
positive regulation of macromolecule biosynthetic processGO:0010557590.051
positive regulation of protein kinase b signalingGO:005189710.050
regulation of rna biosynthetic processGO:20011412130.050
extracellular structure organizationGO:0043062270.050
regulation of anatomical structure morphogenesisGO:00226031300.049
immune system processGO:00023762410.049
vasculature developmentGO:00019442780.049
renal system developmentGO:0072001940.048
negative regulation of response to stimulusGO:00485851040.048
embryonic organ morphogenesisGO:00485622740.048
apoptotic processGO:00069151160.048
epidermis developmentGO:0008544480.048
agingGO:000756820.048
lateral inhibitionGO:004633110.047
epithelial tube morphogenesisGO:00605621480.046
fin morphogenesisGO:0033334530.046
eye morphogenesisGO:00485921440.046
regulation of multicellular organismal developmentGO:20000262230.046
positive regulation of rna metabolic processGO:0051254590.045
cellular ketone metabolic processGO:0042180110.045
phagocytosisGO:000690930.044
positive regulation of cellular biosynthetic processGO:0031328680.044
ameboidal type cell migrationGO:00016671430.044
embryonic limb morphogenesisGO:003032620.043
protein localization to nucleusGO:003450430.043
positive regulation of cell cycleGO:004578730.043
regulation of transcription from rna polymerase ii promoterGO:00063571140.042
response to oxygen containing compoundGO:1901700550.042
developmental growthGO:00485891660.041
response to endogenous stimulusGO:0009719830.040
cell morphogenesisGO:00009022890.040
positive regulation of response to stimulusGO:0048584800.040
retina morphogenesis in camera type eyeGO:0060042790.039
regulation of erk1 and erk2 cascadeGO:007037240.038
regulation of myotube differentiationGO:001083020.038
regulation of inflammatory responseGO:005072720.037
retina development in camera type eyeGO:00600411460.036
regulation of cell deathGO:00109411030.036
single organism organelle organizationGO:19025891990.036
protein processingGO:0016485120.036
somite specificationGO:0001757120.035
regulation of localizationGO:00328791040.035
epidermal cell fate specificationGO:000995740.035
detection of temperature stimulusGO:001604800.035
central nervous system myelinationGO:002201020.035
tube closureGO:006060610.035
regulation of cytokine productionGO:000181730.035
neurological system processGO:0050877620.035
cell migrationGO:00164772370.034
regulation of behaviorGO:0050795240.034
morphogenesis of embryonic epitheliumGO:0016331300.034
cell projection organizationGO:00300302840.034
regulation of cell developmentGO:00602841000.034
inner ear morphogenesisGO:0042472630.034
camera type eye morphogenesisGO:00485931080.033
positive regulation of macromolecule metabolic processGO:0010604930.033
axon developmentGO:00615641660.033
axon guidanceGO:0007411860.032
mesenchymal cell developmentGO:0014031780.032
regulation of protein transportGO:005122330.032
cell cycle g1 s phase transitionGO:004484310.032
positive regulation of cell communicationGO:0010647560.032
mesoderm developmentGO:0007498880.032
urogenital system developmentGO:0001655970.032
single organism transportGO:00447652060.031
mesenchyme developmentGO:00604851270.031
protein importGO:001703830.031
system processGO:00030081850.031
regulation of multicellular organism growthGO:004001440.031
regulation of protein import into nucleusGO:004230620.031
cognitionGO:005089010.031
response to abiotic stimulusGO:00096281220.031
response to xenobiotic stimulusGO:0009410450.031
negative regulation of response to cytokine stimulusGO:006076120.030
positive regulation of nitrogen compound metabolic processGO:0051173690.030
muscle cell differentiationGO:00426921390.030
cellular component movementGO:00069283350.030
regulation of cellular amine metabolic processGO:003323800.030
positive regulation of cellular metabolic processGO:0031325940.030
peptidyl lysine acetylationGO:001839420.029
positive regulation of biosynthetic processGO:0009891680.029
regulation of protein localization to nucleusGO:190018020.029
cranial nerve developmentGO:0021545420.029
connective tissue developmentGO:0061448990.029
blood vessel morphogenesisGO:00485142160.029
venous endothelial cell migration involved in lymph vessel developmentGO:006085540.028
blood vessel endothelial cell migrationGO:0043534180.028
organic substance transportGO:0071702580.028
regulation of programmed cell deathGO:00430671010.028
nucleocytoplasmic transportGO:000691340.028
amine metabolic processGO:000930820.028
cell adhesionGO:0007155400.027
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.027
positive regulation of metabolic processGO:00098931080.027
cellular response to external stimulusGO:007149620.026
homeostatic processGO:00425921420.026
spermatid differentiationGO:004851520.026
regulation of intracellular protein transportGO:003315730.026
anterior posterior pattern specificationGO:00099521520.026
g1 s transition of mitotic cell cycleGO:000008210.026
cell motilityGO:00488702440.026
cell migration involved in gastrulationGO:0042074790.026
regulation of cellular amino acid metabolic processGO:000652100.026
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.026
regulation of cellular component organizationGO:0051128860.025
macromolecule localizationGO:0033036540.025
deathGO:00162651210.025
internal protein amino acid acetylationGO:000647520.025
response to vitaminGO:003327330.025
female gonad developmentGO:000858540.025
regulation of stem cell proliferationGO:007209120.025
positive regulation of map kinase activityGO:004340630.024
cellular amino acid metabolic processGO:000652070.024
neutrophil migrationGO:1990266100.024
positive regulation of signal transductionGO:0009967560.024
response to woundingGO:00096111160.024
cell substrate adhesionGO:003158940.024
wnt signaling pathwayGO:0016055800.024
retinoic acid receptor signaling pathwayGO:0048384160.024
enzyme linked receptor protein signaling pathwayGO:00071671060.023
response to nutrientGO:000758430.023
protein modification processGO:00362111000.023
multicellular organism growthGO:003526440.023
sprouting angiogenesisGO:0002040530.023
hematopoietic or lymphoid organ developmentGO:00485341910.023
protein targeting to nucleusGO:004474430.023
wound healingGO:0042060900.023
organonitrogen compound metabolic processGO:1901564740.023
regulation of cytoplasmic transportGO:190364940.023
positive regulation of transcription dna templatedGO:0045893570.023
positive regulation of developmental processGO:0051094500.023
cell projection morphogenesisGO:00488582440.022
chemotaxisGO:00069351040.022
ectodermal placode morphogenesisGO:0071697320.022
negative regulation of epithelial cell migrationGO:001063310.022
small molecule metabolic processGO:0044281770.022
cellular response to extracellular stimulusGO:003166820.022
neuron projection morphogenesisGO:00488121610.022
positive regulation of cell adhesionGO:004578510.022
regulation of locomotionGO:0040012550.022
cell projection assemblyGO:0030031640.022
odontogenesis of dentin containing toothGO:004247510.021
cellular lipid metabolic processGO:0044255360.021
locomotionGO:00400113130.021
positive regulation of cytokine productionGO:000181920.021
neuron projection guidanceGO:0097485860.021
intracellular signal transductionGO:0035556850.021
sensory perception of painGO:001923310.021
regulation of organ growthGO:004662030.021
programmed cell deathGO:00125011190.021
positive regulation of immune system processGO:0002684170.021
negative regulation of epithelial cell proliferationGO:005068010.020
protein localizationGO:0008104400.020
ectodermal placode developmentGO:0071696370.020
actin filament based processGO:0030029640.020
embryonic epithelial tube formationGO:0001838170.020
regulation of peptidyl tyrosine phosphorylationGO:005073010.020
positive regulation of secretion by cellGO:190353210.020
skeletal system developmentGO:00015011810.020
positive regulation of cellular amine metabolic processGO:003324000.020
photoreceptor cell differentiationGO:0046530550.020
behaviorGO:0007610740.020
stem cell developmentGO:0048864820.019
lateral line developmentGO:0048882660.019
hematopoietic stem cell migrationGO:003570140.019
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.019
positive regulation of cellular component biogenesisGO:004408930.019
positive regulation of locomotionGO:0040017140.019
growthGO:00400071740.019
positive regulation of erk1 and erk2 cascadeGO:007037420.019
neuron migrationGO:0001764220.019
negative regulation of apoptotic processGO:0043066550.019
regulation of protein targetingGO:190353320.019
sex determinationGO:000753010.019
striated muscle cell developmentGO:00550021080.018
cilium morphogenesisGO:0060271850.018
regulation of cell motilityGO:2000145460.018
regulation of cell activationGO:005086510.018
midbrain developmentGO:0030901280.018
stem cell differentiationGO:00488631170.018
multicellular organismal metabolic processGO:004423620.018
positive regulation of secretionGO:005104710.018
protein metabolic processGO:00195381830.018
angiogenesisGO:00015251580.018
skin developmentGO:0043588540.018
regulation of stem cell differentiationGO:200073640.018
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.018
positive regulation of cellular component movementGO:0051272110.018
muscle organ developmentGO:00075171010.017
dna biosynthetic processGO:007189730.017
collagen metabolic processGO:003296320.017
regulation of reproductive processGO:200024140.017
cellular amine metabolic processGO:004410620.017
negative regulation of defense responseGO:003134820.017
protein acetylationGO:000647320.017
epithelial cell fate commitmentGO:0072148110.017
protein secretionGO:000930610.017
cell morphogenesis involved in differentiationGO:00009041950.017
single organismal cell cell adhesionGO:0016337290.017
stem cell divisionGO:001714510.017
regulation of immune system processGO:0002682340.017
nuclear importGO:005117030.017
regulation of blood vessel sizeGO:005088020.017
positive regulation of nucleobase containing compound metabolic processGO:0045935690.017
positive regulation of programmed cell deathGO:0043068290.017
negative regulation of nucleocytoplasmic transportGO:004682320.017
transmission of nerve impulseGO:0019226190.017
dorsal ventral pattern formationGO:00099531250.017
positive regulation of muscle tissue developmentGO:190186310.016
multicellular organismal signalingGO:0035637220.016
negative regulation of cytokine productionGO:000181810.016
fin developmentGO:0033333770.016
embryonic camera type eye developmentGO:0031076290.016
positive regulation of stem cell proliferationGO:200064810.016
specification of symmetryGO:00097992040.016
sensory perceptionGO:0007600390.016
embryonic pattern specificationGO:0009880440.016
glial cell migrationGO:000834730.016
positive regulation of nucleic acid templated transcriptionGO:1903508570.016
midbrain hindbrain boundary developmentGO:0030917230.016
regulation of cell projection assemblyGO:006049140.016
chordate embryonic developmentGO:00430092710.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
neuron fate commitmentGO:0048663260.016
cell proliferation in forebrainGO:002184630.016
hemopoiesisGO:00300971830.016
regulation of cell morphogenesisGO:0022604420.016
somatic muscle developmentGO:000752540.015
regulation of cell differentiationGO:00455951420.015
negative regulation of endothelial cell migrationGO:001059610.015
determination of bilateral symmetryGO:00098552040.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
glomerulus developmentGO:0032835270.015
female sex differentiationGO:004666040.015
mitotic cell cycleGO:0000278640.015
cardiac cell fate commitmentGO:006091110.015
regulation of cell migrationGO:0030334400.015
regulation of bmp signaling pathwayGO:0030510390.015
regulation of protein ubiquitinationGO:003139630.015
regulation of notch signaling pathwayGO:0008593160.015
protein acylationGO:004354330.015
nephron developmentGO:0072006310.015
macromolecule modificationGO:00434121110.015
mechanoreceptor differentiationGO:0042490370.015
regulation of tube sizeGO:003515020.015
morphogenesis of an epithelial sheetGO:0002011490.015
negative regulation of multicellular organismal processGO:0051241690.015
regulation of nucleocytoplasmic transportGO:004682220.014
telencephalon developmentGO:0021537140.014
multi organism processGO:00517041340.014
tube formationGO:0035148250.014
negative regulation of chemotaxisGO:005092240.014
regulation of extrinsic apoptotic signaling pathwayGO:200123630.014
negative regulation of stem cell differentiationGO:200073720.014
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.014
mitotic cell cycle processGO:1903047480.014
muscle tissue developmentGO:00605371100.014
negative regulation of cell migrationGO:0030336170.014
single organism cell adhesionGO:0098602290.014
negative regulation of mapk cascadeGO:004340940.014
response to growth factorGO:0070848390.014
establishment of localization in cellGO:0051649770.014
cell fate specificationGO:0001708680.014
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.014
regulation of neurogenesisGO:0050767870.013
nuclear transportGO:005116940.013
lipid homeostasisGO:005508830.013
embryonic eye morphogenesisGO:0048048300.013
regulation of cellular component movementGO:0051270550.013
epithelial tube formationGO:0072175190.013
blood circulationGO:0008015870.013
cell part morphogenesisGO:00329902460.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
tissue remodelingGO:004877140.013
neural tube patterningGO:0021532330.013
negative regulation of molecular functionGO:0044092230.013
adult behaviorGO:003053420.013
muscle cell developmentGO:00550011150.013
smoothened signaling pathwayGO:0007224300.013
pectoral fin developmentGO:0033339500.013
negative regulation of notch signaling pathwayGO:004574660.013
patterning of blood vesselsGO:0001569150.013
compound eye developmentGO:004874920.013
nephron epithelium morphogenesisGO:007208810.013
positive regulation of cell differentiationGO:0045597300.013
specification of axis polarityGO:006500140.013
positive regulation of cell activationGO:005086710.012
cardiac cell developmentGO:0055006210.012
leukocyte proliferationGO:007066110.012
regulation of cell morphogenesis involved in differentiationGO:0010769380.012
regulation of phGO:000688530.012
regulation of extent of cell growthGO:0061387290.012
positive regulation of leukocyte migrationGO:000268720.012
intracellular transportGO:0046907320.012
positive regulation of cell motilityGO:2000147110.012
negative regulation of cytokine mediated signaling pathwayGO:000196020.012
skeletal muscle organ developmentGO:0060538780.012
regulation of cellular protein metabolic processGO:0032268520.012
regulation of response to stressGO:0080134360.012
endothelium developmentGO:0003158250.011
peptide transportGO:001583310.011
development of primary female sexual characteristicsGO:004654540.011
regionalizationGO:00030022740.011
regulation of dna replicationGO:000627530.011
regulation of angiogenesisGO:0045765260.011
exocrine system developmentGO:0035272280.011
cellular hormone metabolic processGO:0034754190.011
embryonic heart tube developmentGO:00350501330.011
regulation of mrna splicing via spliceosomeGO:004802430.011
endothelial cell migrationGO:0043542190.011
renal tubule developmentGO:006132650.011
endocytosisGO:0006897160.011
regulation of protein metabolic processGO:0051246560.011
negative regulation of protein transportGO:005122430.011
regulation of response to external stimulusGO:0032101310.011
regulation of neutrophil migrationGO:190262260.011
mesenchymal cell differentiationGO:0048762870.011
mitotic dna damage checkpointGO:004477340.011
extracellular matrix organizationGO:0030198270.011
positive regulation of cyclin dependent protein serine threonine kinase activityGO:004573710.011
regulation of neutrophil chemotaxisGO:009002250.011
neural crest cell developmentGO:0014032620.011
regulation of bindingGO:005109830.011
fibroblast growth factor receptor signaling pathwayGO:0008543220.011
establishment of protein localization to organelleGO:007259440.011
cellular protein metabolic processGO:00442671290.011
segment polarity determinationGO:000736710.011

plekhg4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.046
cardiovascular system diseaseDOID:128700.022
bone diseaseDOID:008000100.020
musculoskeletal system diseaseDOID:1700.020
connective tissue diseaseDOID:6500.020
bone development diseaseDOID:008000600.020
nervous system diseaseDOID:86300.014