Danio rerio

2 known processes

shmt2

serine hydroxymethyltransferase 2 (mitochondrial)

shmt2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
circadian sleep wake cycle processGO:002241020.423
tube morphogenesisGO:00352393490.383
muscle cell differentiationGO:00426921390.367
circadian sleep wake cycleGO:004274520.346
negative regulation of hydrolase activityGO:0051346100.319
organic cyclic compound metabolic processGO:19013603010.298
positive regulation of glucose transportGO:001082810.294
muscle structure developmentGO:00610611960.287
heart developmentGO:00075073130.261
glucose importGO:004632320.255
vasculature developmentGO:00019442780.246
positive regulation of biological processGO:00485182530.227
immune system processGO:00023762410.209
regulation of circadian sleep wake cycleGO:004274910.191
nitrogen compound metabolic processGO:00068073190.189
aromatic compound biosynthetic processGO:00194382170.181
larval developmentGO:000216420.179
response to stressGO:00069502630.169
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.168
regulation of glucose transportGO:001082710.168
female sex differentiationGO:004666040.164
blood vessel morphogenesisGO:00485142160.162
regulation of peptidase activityGO:0052547230.159
positive regulation of glucose importGO:004632610.158
neuron differentiationGO:00301823530.150
sleepGO:003043110.150
gene expressionGO:00104672520.144
cellular component morphogenesisGO:00329893360.141
signal transductionGO:00071654550.139
modulation by virus of host morphology or physiologyGO:001904810.139
determination of heart left right asymmetryGO:00613711170.137
regulation of circadian sleep wake cycle sleepGO:004518710.137
agingGO:000756820.135
cellular response to external stimulusGO:007149620.134
pyruvate metabolic processGO:000609010.130
digestive tract morphogenesisGO:00485462310.130
regulation of signalingGO:00230512350.130
specification of symmetryGO:00097992040.129
circadian rhythmGO:0007623190.125
organic acid catabolic processGO:001605430.125
regulation of signal transductionGO:00099662250.124
cellular component movementGO:00069283350.122
cellular aromatic compound metabolic processGO:00067252950.122
negative regulation of gene expressionGO:0010629650.122
circadian sleep wake cycle sleepGO:005080210.121
embryonic organ morphogenesisGO:00485622740.120
response to external stimulusGO:00096052640.119
immune system developmentGO:00025201910.119
reactive nitrogen species metabolic processGO:200105700.114
maintenance of locationGO:005123540.114
regulation of circadian rhythmGO:004275240.112
establishment of protein localization to organelleGO:007259440.111
rna biosynthetic processGO:00327741810.110
regulation of cell communicationGO:00106462320.109
regulation of multicellular organismal developmentGO:20000262230.109
negative regulation of cellular processGO:00485232830.108
protein importGO:001703830.107
heterocycle metabolic processGO:00464832900.105
generation of neuronsGO:00486993850.103
regulation of response to nutrient levelsGO:003210710.103
response to xenobiotic stimulusGO:0009410450.103
regulation of biological qualityGO:00650082630.101
neuron developmentGO:00486662620.099
cellular macromolecule biosynthetic processGO:00346452240.099
regulation of cellular carbohydrate metabolic processGO:001067540.099
rna metabolic processGO:00160702190.098
muscle tissue developmentGO:00605371100.097
response to nutrientGO:000758430.095
autophagyGO:000691440.094
single organism metabolic processGO:00447102170.092
regulation of nitrogen compound metabolic processGO:00511712510.091
regulation of cell differentiationGO:00455951420.090
positive regulation of cellular metabolic processGO:0031325940.090
cell migrationGO:00164772370.090
negative regulation of biological processGO:00485193040.089
striated muscle cell differentiationGO:00511461290.089
nuclear transportGO:005116940.089
regulation of primary metabolic processGO:00800903110.087
regulation of protein maturationGO:1903317100.086
negative regulation of endopeptidase activityGO:0010951100.086
organic cyclic compound biosynthetic processGO:19013622230.086
oocyte maturationGO:000155640.085
cellular macromolecule metabolic processGO:00442603910.085
hematopoietic or lymphoid organ developmentGO:00485341910.084
epithelial tube morphogenesisGO:00605621480.084
regulation of autophagyGO:001050630.082
regulation of intracellular protein transportGO:003315730.081
modification dependent macromolecule catabolic processGO:004363230.080
cellular nitrogen compound metabolic processGO:00346412900.080
positive regulation of nitrogen compound metabolic processGO:0051173690.080
regulation of cysteine type endopeptidase activityGO:2000116210.080
positive regulation of cellular component biogenesisGO:004408930.079
glucose homeostasisGO:004259310.078
protein localization to nucleusGO:003450430.078
blood vessel developmentGO:00015682460.078
protein import into nucleusGO:000660630.077
lipid storageGO:001991510.076
regulation of oocyte developmentGO:006028130.075
regulation of macromolecule biosynthetic processGO:00105562250.074
establishment of localizationGO:00512342440.074
embryonic organ developmentGO:00485683810.074
nitric oxide metabolic processGO:004620920.073
extrinsic apoptotic signaling pathwayGO:009719130.073
positive regulation of catabolic processGO:000989640.072
regulation of protein targetingGO:190353320.072
regulation of response to stimulusGO:00485832690.070
regulation of endopeptidase activityGO:0052548230.069
nuclear importGO:005117030.069
cell projection morphogenesisGO:00488582440.068
regulation of protein import into nucleusGO:004230620.068
nucleobase containing compound metabolic processGO:00061392740.067
astrocyte differentiationGO:004870810.067
organic substance biosynthetic processGO:19015762890.066
nucleobase containing compound biosynthetic processGO:00346542050.065
b cell differentiationGO:003018310.065
response to other organismGO:0051707970.065
determination of bilateral symmetryGO:00098552040.065
sensory organ developmentGO:00074233930.064
determination of dorsal ventral asymmetryGO:0048262340.064
meiotic nuclear divisionGO:000712640.064
cell agingGO:000756920.064
response to vitaminGO:003327330.063
single organism nuclear importGO:190259330.063
biosynthetic processGO:00090582940.062
cell projection organizationGO:00300302840.062
nitric oxide biosynthetic processGO:000680920.062
positive regulation of macromolecule biosynthetic processGO:0010557590.062
regulation of cell activationGO:005086510.061
neuron projection developmentGO:00311751800.060
regulation of meiotic cell cycleGO:005144510.060
ear developmentGO:00435831270.059
cellular amine metabolic processGO:004410620.059
reactive oxygen species biosynthetic processGO:190340910.059
cellular ketone metabolic processGO:0042180110.058
regulation of organ growthGO:004662030.058
oxoacid metabolic processGO:0043436310.058
embryonic heart tube developmentGO:00350501330.058
cell morphogenesis involved in neuron differentiationGO:00486671630.057
cell deathGO:00082191210.057
positive regulation of cellular biosynthetic processGO:0031328680.057
regulation of cellular macromolecule biosynthetic processGO:20001122220.057
positive regulation of metabolic processGO:00098931080.056
regulation of protein complex assemblyGO:004325430.056
regulation of metabolic processGO:00192223590.055
response to activityGO:0014823140.055
cellular protein catabolic processGO:004425740.055
regulation of gene expressionGO:00104682650.055
nucleic acid metabolic processGO:00903042440.055
nucleocytoplasmic transportGO:000691340.054
positive regulation of cellular carbohydrate metabolic processGO:001067610.054
regulation of cellular ketone metabolic processGO:001056570.054
positive regulation of cell cycleGO:004578730.054
small molecule metabolic processGO:0044281770.054
striated muscle cell developmentGO:00550021080.053
central nervous system neuron differentiationGO:0021953740.053
regulation of nervous system developmentGO:0051960900.052
growthGO:00400071740.052
regulation of embryonic developmentGO:0045995470.052
protein targeting to nucleusGO:004474430.052
leukocyte proliferationGO:007066110.051
liver developmentGO:0001889960.051
macromolecule biosynthetic processGO:00090592270.051
determination of left right symmetryGO:00073681790.051
interaction with hostGO:005170140.051
regulation of sodium ion transportGO:000202820.050
positive regulation of transportGO:005105020.050
morphogenesis of an epitheliumGO:00020093330.050
response to carbohydrateGO:000974330.050
negative regulation of macromolecule metabolic processGO:0010605760.050
localization of cellGO:00516742440.050
regulation of lipid catabolic processGO:005099420.050
regulation of establishment of protein localizationGO:007020140.050
negative regulation of peptidase activityGO:0010466100.049
organelle organizationGO:00069962270.049
negative regulation of protein processingGO:0010955100.049
negative regulation of tor signalingGO:003200720.049
type b pancreatic cell developmentGO:000332340.049
negative regulation of metabolic processGO:0009892860.049
response to woundingGO:00096111160.049
locomotionGO:00400113130.049
system processGO:00030081850.049
regulation of biosynthetic processGO:00098892500.049
symbiosis encompassing mutualism through parasitismGO:004440340.048
multi organism cellular processGO:004476420.048
digestive system developmentGO:00551232890.048
modification of morphology or physiology of other organismGO:003582140.048
regulation of protein transportGO:005122330.048
regulation of nucleobase containing compound metabolic processGO:00192192500.048
cell substrate adhesionGO:003158940.048
mitochondrion organizationGO:000700540.047
single organism organelle organizationGO:19025891990.047
ameboidal type cell migrationGO:00016671430.047
negative regulation of proteolysisGO:0045861100.047
cellular biosynthetic processGO:00442492860.047
striated muscle tissue developmentGO:00147061100.046
regulation of protein catabolic processGO:004217610.046
regulation of carbohydrate metabolic processGO:000610940.046
hemopoiesisGO:00300971830.046
positive regulation of cellular amino acid metabolic processGO:004576400.046
positive regulation of nucleobase containing compound metabolic processGO:0045935690.045
regulation of cytoplasmic transportGO:190364940.045
sodium ion transportGO:0006814240.045
eye developmentGO:00016542770.045
cellular carbohydrate metabolic processGO:004426240.045
carboxylic acid metabolic processGO:0019752220.045
proteolysisGO:0006508380.045
germ line stem cell divisionGO:004207810.045
mesenchymal cell proliferationGO:001046310.044
cardiac cell developmentGO:0055006210.044
cell surface receptor signaling pathwayGO:00071663250.044
immune responseGO:0006955280.044
single organism reproductive processGO:0044702400.044
regulation of cellular metabolic processGO:00313233200.043
amine metabolic processGO:000930820.043
embryonic hemopoiesisGO:0035162530.043
regulation of intracellular signal transductionGO:1902531570.043
organonitrogen compound metabolic processGO:1901564740.043
regulation of apoptotic processGO:0042981980.043
embryo development ending in birth or egg hatchingGO:00097922710.043
cellular response to extracellular stimulusGO:003166820.042
viral processGO:001603210.042
regulation of extrinsic apoptotic signaling pathwayGO:200123630.042
digestive tract developmentGO:00485652650.042
nuclear migrationGO:000709730.042
organic acid metabolic processGO:0006082310.042
negative regulation of protein localization to nucleusGO:190018120.042
modification by symbiont of host morphology or physiologyGO:004400340.042
renal system developmentGO:0072001940.041
cell part morphogenesisGO:00329902460.041
taxisGO:00423301090.040
peptidyl serine modificationGO:001820920.040
hormone metabolic processGO:0042445190.040
regulation of dna replicationGO:000627530.040
cellular response to nutrient levelsGO:003166920.039
cell motilityGO:00488702440.039
carboxylic acid catabolic processGO:004639530.039
gastrulationGO:00073692080.039
positive regulation of cell activationGO:005086710.039
single organism biosynthetic processGO:0044711710.038
axonogenesisGO:00074091520.038
cell morphogenesisGO:00009022890.038
proteolysis involved in cellular protein catabolic processGO:005160330.038
heart loopingGO:0001947940.038
aflatoxin b1 metabolic processGO:004339010.038
positive regulation of rna biosynthetic processGO:1902680570.038
neuron projection morphogenesisGO:00488121610.037
regulation of cell deathGO:00109411030.037
positive regulation of gene expressionGO:0010628710.037
regulation of protein localization to nucleusGO:190018020.037
regulation of programmed cell deathGO:00430671010.037
muscle cell developmentGO:00550011150.037
proteasomal protein catabolic processGO:001049820.037
regulation of macromolecule metabolic processGO:00602553170.037
negative regulation of cellular metabolic processGO:0031324770.037
regulation of developmental processGO:00507932470.037
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.036
positive regulation of lipid metabolic processGO:004583410.036
regulation of gtp catabolic processGO:003312420.036
response to external biotic stimulusGO:0043207970.036
positive regulation of signalingGO:0023056560.036
stem cell maintenanceGO:001982740.036
modification dependent protein catabolic processGO:001994130.036
nephron morphogenesisGO:007202820.036
cell proliferationGO:0008283800.036
multicellular organism growthGO:003526440.035
wound healingGO:0042060900.035
defense response to other organismGO:0098542330.035
lipid catabolic processGO:001604240.035
deathGO:00162651210.035
positive regulation of stress activated mapk cascadeGO:003287430.035
nucleic acid templated transcriptionGO:00976591810.035
regulation of glucose importGO:004632410.035
regulation of cellular biosynthetic processGO:00313262450.035
intracellular signal transductionGO:0035556850.034
positive regulation of carbohydrate metabolic processGO:004591310.034
programmed cell deathGO:00125011190.034
heart morphogenesisGO:00030071560.034
regulation of response to stressGO:0080134360.034
positive regulation of cellular catabolic processGO:003133130.034
protein processingGO:0016485120.034
synaptic growth at neuromuscular junctionGO:005112420.033
small molecule catabolic processGO:004428230.033
carbohydrate homeostasisGO:003350010.033
regulation of multicellular organismal processGO:00512392770.033
carbohydrate biosynthetic processGO:001605110.033
transcription from rna polymerase ii promoterGO:0006366800.033
fatty acid oxidationGO:001939510.033
establishment or maintenance of polarity of embryonic epitheliumGO:001633220.033
hydrogen peroxide metabolic processGO:004274320.032
determination of ventral identityGO:0048264210.032
chordate embryonic developmentGO:00430092710.032
regulation of proteolysisGO:0030162240.032
negative regulation of nucleobase containing compound metabolic processGO:0045934590.032
regulation of hormone secretionGO:004688320.032
cardiac muscle tissue developmentGO:0048738480.032
positive regulation of gliogenesisGO:001401520.032
angiogenesisGO:00015251580.032
semicircular canal developmentGO:0060872240.032
regulation of rna biosynthetic processGO:20011412130.032
mononuclear cell proliferationGO:003294310.031
regulation of defense response to virus by hostGO:005069110.031
regulation of nucleocytoplasmic transportGO:004682220.031
smooth muscle tissue developmentGO:004874510.031
rhythmic processGO:0048511210.031
energy reserve metabolic processGO:000611220.031
regulation of catalytic activityGO:0050790550.031
response to biotic stimulusGO:0009607970.030
regulation of cellular amine metabolic processGO:003323800.030
oxidation reduction processGO:0055114410.030
centrosome organizationGO:005129710.030
negative regulation of cysteine type endopeptidase activityGO:200011780.030
cellular nitrogen compound biosynthetic processGO:00442712180.030
regulation of multicellular organism growthGO:004001440.030
long chain fatty acid transportGO:001590910.030
lipid homeostasisGO:005508830.030
retina development in camera type eyeGO:00600411460.030
dorsal ventral pattern formationGO:00099531250.030
positive regulation of molecular functionGO:0044093330.030
regulation of transcription from rna polymerase ii promoterGO:00063571140.029
embryonic heart tube morphogenesisGO:00031431080.029
insulin like growth factor receptor signaling pathwayGO:004800940.029
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.029
mycotoxin metabolic processGO:004338510.029
regulation of cytokine productionGO:000181730.029
development of primary female sexual characteristicsGO:004654540.029
positive regulation of response to stimulusGO:0048584800.028
cellular response to starvationGO:000926710.028
segmentationGO:0035282970.028
response to chemicalGO:00422213200.028
immune effector processGO:0002252230.028
interspecies interaction between organismsGO:004441940.028
negative regulation of protein maturationGO:1903318100.028
cell growthGO:0016049570.028
pericardium developmentGO:006003910.028
axon developmentGO:00615641660.028
regulation of response to extracellular stimulusGO:003210410.027
multi organism processGO:00517041340.027
neural retina developmentGO:0003407490.027
cognitionGO:005089010.027
retina morphogenesis in camera type eyeGO:0060042790.027
negative regulation of cellular biosynthetic processGO:0031327550.027
transcription dna templatedGO:00063511810.027
kidney developmentGO:0001822920.027
response to hexoseGO:000974630.027
regulation of cell developmentGO:00602841000.027
response to monosaccharideGO:003428430.026
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.026
fin regenerationGO:0031101510.026
regulation of type b pancreatic cell developmentGO:200007410.026
protein maturationGO:0051604120.026
hepaticobiliary system developmentGO:0061008980.026
apoptotic processGO:00069151160.026
alpha amino acid metabolic processGO:190160530.026
b cell activationGO:004211320.026
regulation of cellular component organizationGO:0051128860.025
negative regulation of catabolic processGO:000989530.025
pancreas developmentGO:0031016840.025
regulation of synaptic plasticityGO:004816710.025
regulation of endodermal cell differentiationGO:1903224150.025
cardiac muscle cell developmentGO:0055013200.025
regulation of carbohydrate biosynthetic processGO:004325510.025
regulation of reproductive processGO:200024140.025
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.025
camera type eye developmentGO:00430102220.025
endodermal cell fate determinationGO:000749320.025
stem cell divisionGO:001714510.025
response to glucoseGO:000974930.025
cellular component assemblyGO:00226071700.025
phosphate containing compound metabolic processGO:00067961080.025
adherens junction organizationGO:003433240.024
negative regulation of signalingGO:0023057960.024
guanosine containing compound metabolic processGO:190106840.024
brain developmentGO:00074202930.024
regulation of cellular amino acid metabolic processGO:000652100.024
tissue regenerationGO:0042246740.024
female gonad developmentGO:000858540.024
photoreceptor cell morphogenesisGO:000859410.024
gastrulation with mouth forming secondGO:0001702440.024
positive regulation of biosynthetic processGO:0009891680.024
gland developmentGO:00487321430.023
somatic muscle developmentGO:000752540.023
myotube differentiationGO:0014902450.023
cellular response to oxygen levelsGO:007145310.023
regulation of anatomical structure morphogenesisGO:00226031300.023
response to organic substanceGO:00100331530.023
intestinal absorptionGO:005089220.023
ubiquitin dependent protein catabolic processGO:000651130.023
sensory perception of painGO:001923310.022
stem cell proliferationGO:007208940.022
regulation of gastrulationGO:0010470240.022
negative regulation of biosynthetic processGO:0009890550.022
regulation of transcription dna templatedGO:00063552130.022
swim bladder inflationGO:004879850.022
protein modification processGO:00362111000.022
secondary metabolic processGO:001974830.022
transmission of nerve impulseGO:0019226190.022
positive regulation of developmental processGO:0051094500.022
regulation of tube sizeGO:003515020.022
response to organic cyclic compoundGO:0014070510.022
diencephalon developmentGO:0021536580.022
lymphocyte proliferationGO:004665110.022
negative regulation of macromolecule biosynthetic processGO:0010558480.022
aflatoxin metabolic processGO:004622210.022
regulation of transporter activityGO:003240920.022
dna templated transcription initiationGO:000635210.022
regulation of nucleic acid templated transcriptionGO:19035062130.021
cellular response to chemical stimulusGO:00708871570.021
negative regulation of nitrogen compound metabolic processGO:0051172590.021
negative regulation of cell deathGO:0060548600.021
response to decreased oxygen levelsGO:0036293250.021
cardiac atrium developmentGO:000323040.021
xenobiotic metabolic processGO:000680540.021
neuron projection guidanceGO:0097485860.021
regionalizationGO:00030022740.021
regulation of reactive oxygen species metabolic processGO:200037720.021
regulation of molecular functionGO:0065009700.021
positive regulation of cytokine productionGO:000181920.021
blood circulationGO:0008015870.021
heterocycle biosynthetic processGO:00181302150.021
activation of mapk activityGO:000018730.021
epithelial cell differentiationGO:00308551160.021
response to glucocorticoidGO:005138410.021
positive regulation of striated muscle tissue developmentGO:004584410.021
regulation of hydrolase activityGO:0051336280.020
negative regulation of cellular catabolic processGO:003133030.020
protein secretionGO:000930610.020
columnar cuboidal epithelial cell differentiationGO:0002065380.020
negative regulation of protein phosphorylationGO:000193340.020
morphogenesis of a branching structureGO:0001763210.020
macromolecular complex subunit organizationGO:0043933740.020
positive regulation of dna metabolic processGO:005105410.020
positive regulation of transcription dna templatedGO:0045893570.020
regulation of wound healingGO:006104120.020
mesenchyme developmentGO:00604851270.020
negative regulation of intracellular protein transportGO:009031730.020
negative regulation of cytoplasmic transportGO:190365020.020
protein heterooligomerizationGO:005129110.020
endoderm formationGO:0001706290.020
cell matrix adhesionGO:000716040.020
glandular epithelial cell differentiationGO:000206790.019
cellular response to stressGO:0033554620.019
phosphorus metabolic processGO:00067931090.019
hormone secretionGO:004687920.019
positive regulation of cellular amine metabolic processGO:003324000.019
tissue remodelingGO:004877140.019
regulation of cell cycleGO:0051726520.019
gamete generationGO:0007276330.019
swim bladder developmentGO:0048794190.019
regulation of jak stat cascadeGO:004642530.019
cellular amino acid metabolic processGO:000652070.019
regulation of cellular component sizeGO:0032535300.019
urogenital system developmentGO:0001655970.018
regulation of cellular protein catabolic processGO:190336210.018
organic heteropentacyclic compound metabolic processGO:190137610.018
regulation of skeletal muscle tissue developmentGO:004864140.018
sensory organ morphogenesisGO:00905962000.018
circadian regulation of gene expressionGO:003292280.018
carbohydrate derivative biosynthetic processGO:1901137430.018
negative regulation of programmed cell deathGO:0043069580.018
negative regulation of cysteine type endopeptidase activity involved in apoptotic processGO:004315470.018
positive regulation of macromolecule metabolic processGO:0010604930.018
organonitrogen compound biosynthetic processGO:1901566470.018
fatty acid transportGO:001590810.018
regulation of blood vessel sizeGO:005088020.018
regulation of mrna processingGO:005068430.018
regulation of purine nucleotide catabolic processGO:003312120.018
nephron tubule morphogenesisGO:007207810.018
regulation of hormone levelsGO:0010817210.018
cell fate commitmentGO:0045165990.018
cellular lipid catabolic processGO:004424230.017
lipid oxidationGO:003444010.017
regulation of cell maturationGO:190342910.017
macromolecule modificationGO:00434121110.017
mesoderm developmentGO:0007498880.017
positive chemotaxisGO:005091850.017
regulation of stem cell proliferationGO:007209120.017
cellular hormone metabolic processGO:0034754190.017
response to abiotic stimulusGO:00096281220.017
cell cycleGO:0007049930.017
regulation of metal ion transportGO:001095940.017
er nucleus signaling pathwayGO:000698420.017
camera type eye photoreceptor cell differentiationGO:0060219190.017
ventral spinal cord developmentGO:0021517350.017
regulation of chondrocyte differentiationGO:003233010.017
cardiocyte differentiationGO:0035051440.017
response to alkaloidGO:004327920.017
negative regulation of muscle cell differentiationGO:005114810.017

shmt2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.037
nervous system diseaseDOID:86300.037
disease of metabolismDOID:001466700.031
inherited metabolic disorderDOID:65500.028
carbohydrate metabolic disorderDOID:297800.028
hyperinsulinemic hypoglycemiaDOID:1331700.028
eye and adnexa diseaseDOID:149200.021
eye diseaseDOID:561400.021
sensory system diseaseDOID:005015500.021