Danio rerio

0 known processes

lgi3

leucine-rich repeat LGI family, member 3

(Aliases: si:ch211-198o12.2)

lgi3 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.079
agingGO:000756820.076
embryonic organ developmentGO:00485683810.066
neuron differentiationGO:00301823530.063
cellular macromolecule metabolic processGO:00442603910.060
central nervous system developmentGO:00074173870.059
Zebrafish
regulation of cellular metabolic processGO:00313233200.056
regulation of primary metabolic processGO:00800903110.055
gene expressionGO:00104672520.054
cell projection morphogenesisGO:00488582440.053
regulation of metabolic processGO:00192223590.053
chordate embryonic developmentGO:00430092710.051
head developmentGO:00603223030.050
Zebrafish
heterocycle metabolic processGO:00464832900.050
generation of neuronsGO:00486993850.050
signal transductionGO:00071654550.050
regulation of biosynthetic processGO:00098892500.049
sensory organ developmentGO:00074233930.049
nitrogen compound metabolic processGO:00068073190.049
heterocycle biosynthetic processGO:00181302150.049
positive regulation of biological processGO:00485182530.048
regulation of macromolecule metabolic processGO:00602553170.047
cellular aromatic compound metabolic processGO:00067252950.047
cellular biosynthetic processGO:00442492860.047
cell morphogenesisGO:00009022890.047
cellular component morphogenesisGO:00329893360.046
vasculature developmentGO:00019442780.046
amine metabolic processGO:000930820.046
organic cyclic compound metabolic processGO:19013603010.046
cellular nitrogen compound metabolic processGO:00346412900.046
organic substance biosynthetic processGO:19015762890.046
regulation of nitrogen compound metabolic processGO:00511712510.045
embryonic organ morphogenesisGO:00485622740.044
biosynthetic processGO:00090582940.044
negative regulation of cellular processGO:00485232830.044
negative regulation of biological processGO:00485193040.044
cellular amine metabolic processGO:004410620.043
neuron developmentGO:00486662620.043
regulation of cellular amine metabolic processGO:003323800.042
response to chemicalGO:00422213200.042
response to stressGO:00069502630.042
cell part morphogenesisGO:00329902460.042
positive regulation of transportGO:005105020.041
organic cyclic compound biosynthetic processGO:19013622230.041
eye developmentGO:00016542770.041
immune system processGO:00023762410.039
regulation of cellular biosynthetic processGO:00313262450.039
nucleobase containing compound biosynthetic processGO:00346542050.038
regulation of establishment of protein localizationGO:007020140.038
cell surface receptor signaling pathwayGO:00071663250.038
multicellular organism growthGO:003526440.038
rna metabolic processGO:00160702190.038
protein localization to nucleusGO:003450430.038
morphogenesis of an epitheliumGO:00020093330.037
regulation of signal transductionGO:00099662250.037
establishment of protein localization to organelleGO:007259440.036
regulation of macromolecule biosynthetic processGO:00105562250.036
tube morphogenesisGO:00352393490.036
cellular component movementGO:00069283350.036
positive regulation of cellular processGO:00485222010.036
cellular nitrogen compound biosynthetic processGO:00442712180.036
maintenance of locationGO:005123540.035
response to external stimulusGO:00096052640.035
nucleic acid metabolic processGO:00903042440.035
regulation of response to stimulusGO:00485832690.035
regulation of cellular amino acid metabolic processGO:000652100.035
blood vessel developmentGO:00015682460.035
camera type eye developmentGO:00430102220.035
regulation of signalingGO:00230512350.035
regulation of nucleic acid templated transcriptionGO:19035062130.035
regulation of cellular macromolecule biosynthetic processGO:20001122220.035
adult behaviorGO:003053420.034
cell projection organizationGO:00300302840.033
nucleocytoplasmic transportGO:000691340.033
regulation of biological qualityGO:00650082630.033
Zebrafish
regulation of developmental processGO:00507932470.033
regulation of gene expressionGO:00104682650.033
regulation of multicellular organism growthGO:004001440.033
locomotionGO:00400113130.033
macromolecule biosynthetic processGO:00090592270.033
regulation of protein transportGO:005122330.033
cellular protein catabolic processGO:004425740.032
regulation of peptidyl tyrosine phosphorylationGO:005073010.032
regulation of multicellular organismal processGO:00512392770.031
rna biosynthetic processGO:00327741810.031
cognitionGO:005089010.031
regulation of cellular ketone metabolic processGO:001056570.031
embryo development ending in birth or egg hatchingGO:00097922710.031
embryonic skeletal system developmentGO:0048706970.031
lipid storageGO:001991510.030
regulation of cytoplasmic transportGO:190364940.030
digestive system developmentGO:00551232890.030
establishment of localizationGO:00512342440.030
Mouse
protein targeting to nucleusGO:004474430.030
cellular ketone metabolic processGO:0042180110.030
protein metabolic processGO:00195381830.029
cell motilityGO:00488702440.029
protein importGO:001703830.029
nucleobase containing compound metabolic processGO:00061392740.029
phagocytosisGO:000690930.029
cellular macromolecule biosynthetic processGO:00346452240.029
regulation of transcription dna templatedGO:00063552130.029
nucleic acid templated transcriptionGO:00976591810.029
sensory organ morphogenesisGO:00905962000.029
transcription dna templatedGO:00063511810.029
angiogenesisGO:00015251580.029
brain developmentGO:00074202930.029
Zebrafish
determination of bilateral symmetryGO:00098552040.029
negative regulation of protein phosphorylationGO:000193340.029
single organism nuclear importGO:190259330.029
heart developmentGO:00075073130.029
positive regulation of cell cycleGO:004578730.028
cell morphogenesis involved in differentiationGO:00009041950.028
stem cell maintenanceGO:001982740.028
neuron neuron synaptic transmissionGO:000727010.028
regulation of rna biosynthetic processGO:20011412130.028
skeletal system developmentGO:00015011810.028
positive regulation of cellular amino acid metabolic processGO:004576400.028
proteolysis involved in cellular protein catabolic processGO:005160330.027
blood vessel morphogenesisGO:00485142160.027
protein import into nucleusGO:000660630.027
aromatic compound biosynthetic processGO:00194382170.027
nuclear transportGO:005116940.027
nuclear importGO:005117030.027
ear developmentGO:00435831270.027
single organism metabolic processGO:00447102170.027
regulation of cell communicationGO:00106462320.027
transportGO:00068102200.027
Mouse
mesenchyme developmentGO:00604851270.027
proteasomal protein catabolic processGO:001049820.026
organelle organizationGO:00069962270.026
modification dependent protein catabolic processGO:001994130.026
organic acid metabolic processGO:0006082310.026
oxoacid metabolic processGO:0043436310.026
regulation of multicellular organismal developmentGO:20000262230.026
small molecule metabolic processGO:0044281770.026
response to drugGO:004249330.026
organonitrogen compound metabolic processGO:1901564740.026
positive regulation of catabolic processGO:000989640.026
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.026
cellular protein metabolic processGO:00442671290.025
axonogenesisGO:00074091520.025
regulation of protein import into nucleusGO:004230620.025
inner ear developmentGO:00488391260.025
cellular response to external stimulusGO:007149620.025
muscle structure developmentGO:00610611960.025
regulation of reproductive processGO:200024140.025
neuron projection developmentGO:00311751800.025
regionalizationGO:00030022740.025
regulation of rna metabolic processGO:00512522240.024
cell substrate adhesionGO:003158940.024
regulation of cytokine productionGO:000181730.024
cell migrationGO:00164772370.024
positive regulation of cellular amine metabolic processGO:003324000.024
regulation of intracellular protein transportGO:003315730.024
guanosine containing compound metabolic processGO:190106840.024
gtp metabolic processGO:004603940.024
determination of left right symmetryGO:00073681790.024
regulation of nucleobase containing compound metabolic processGO:00192192500.024
axon developmentGO:00615641660.024
homeostatic processGO:00425921420.024
modification dependent macromolecule catabolic processGO:004363230.024
regulation of protein targetingGO:190353320.023
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.023
ubiquitin dependent protein catabolic processGO:000651130.023
exocytosisGO:000688710.023
Mouse
regulation of bindingGO:005109830.023
positive regulation of cellular catabolic processGO:003133130.023
positive regulation of cellular component biogenesisGO:004408930.023
regulation of dendrite morphogenesisGO:004881430.023
regulation of protein localization to nucleusGO:190018020.023
regulation of metal ion transportGO:001095940.022
embryonic skeletal system morphogenesisGO:0048704930.022
positive regulation of nitrogen compound metabolic processGO:0051173690.022
retina development in camera type eyeGO:00600411460.022
regulation of cell activationGO:005086510.022
gtp catabolic processGO:000618420.022
digestive tract developmentGO:00485652650.022
regulation of extrinsic apoptotic signaling pathwayGO:200123630.022
localization of cellGO:00516742440.022
single organism localizationGO:19025782250.022
Mouse
guanosine containing compound catabolic processGO:190106920.022
cell morphogenesis involved in neuron differentiationGO:00486671630.022
system processGO:00030081850.022
Zebrafish
neuron projection morphogenesisGO:00488121610.022
mitochondrion organizationGO:000700540.022
extrinsic apoptotic signaling pathwayGO:009719130.021
cilium morphogenesisGO:0060271850.021
peptide transportGO:001583310.021
carboxylic acid metabolic processGO:0019752220.021
camera type eye morphogenesisGO:00485931080.021
autophagyGO:000691440.021
cilium organizationGO:0044782710.021
stem cell proliferationGO:007208940.020
specification of symmetryGO:00097992040.020
negative regulation of protein kinase activityGO:000646940.020
glucose homeostasisGO:004259310.020
response to monosaccharideGO:003428430.020
mononuclear cell proliferationGO:003294310.020
gastrulationGO:00073692080.020
cellular amino acid metabolic processGO:000652070.020
response to carbohydrateGO:000974330.020
hemopoiesisGO:00300971830.020
regulation of epithelial cell proliferationGO:005067830.020
leukocyte proliferationGO:007066110.020
regulation of protein complex assemblyGO:004325430.020
embryonic cranial skeleton morphogenesisGO:0048701900.020
positive regulation of immune effector processGO:000269930.019
regulation of dendrite developmentGO:005077330.019
lipid catabolic processGO:001604240.019
skeletal system morphogenesisGO:00487051020.019
protein modification processGO:00362111000.019
digestive tract morphogenesisGO:00485462310.019
positive regulation of cytokine productionGO:000181920.019
transcription from rna polymerase ii promoterGO:0006366800.019
compound eye developmentGO:004874920.019
negative regulation of protein transportGO:005122430.019
response to hexoseGO:000974630.019
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.019
single organism organelle organizationGO:19025891990.018
neurotransmitter transportGO:000683620.018
positive regulation of secretionGO:005104710.018
synaptic growth at neuromuscular junctionGO:005112420.018
internal protein amino acid acetylationGO:000647520.018
regulation of cell shapeGO:000836010.018
secondary metabolic processGO:001974830.018
regulation of nucleocytoplasmic transportGO:004682220.018
carbohydrate homeostasisGO:003350010.018
response to organic substanceGO:00100331530.018
single organism transportGO:00447652060.018
Mouse
gland developmentGO:00487321430.018
positive regulation of cell activationGO:005086710.018
cellular response to extracellular stimulusGO:003166820.018
eye morphogenesisGO:00485921440.017
hormone transportGO:000991420.017
negative regulation of kinase activityGO:003367340.017
chemosensory behaviorGO:000763510.017
liver developmentGO:0001889960.017
meiotic nuclear divisionGO:000712640.017
response to alkaloidGO:004327920.017
peptidyl lysine acetylationGO:001839420.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
regulation of stem cell proliferationGO:007209120.017
epithelial cell differentiationGO:00308551160.017
regulation of synapse assemblyGO:005196330.017
pancreas developmentGO:0031016840.017
protein acetylationGO:000647320.017
regulation of erk1 and erk2 cascadeGO:007037240.017
peptidyl serine phosphorylationGO:001810510.017
protein localization to plasma membraneGO:007265910.017
regulation of purine nucleotide catabolic processGO:003312120.017
response to glucoseGO:000974930.017
regulation of programmed cell deathGO:00430671010.017
fertilizationGO:000956630.016
positive regulation of secretion by cellGO:190353210.016
regulation of inflammatory responseGO:005072720.016
regulation of reactive oxygen species metabolic processGO:200037720.016
hepaticobiliary system developmentGO:0061008980.016
anterior posterior pattern specificationGO:00099521520.016
adherens junction organizationGO:003433240.016
cell matrix adhesionGO:000716040.016
regulation of autophagyGO:001050630.016
negative regulation of catabolic processGO:000989530.016
regenerationGO:0031099910.016
positive regulation of apoptotic signaling pathwayGO:200123510.016
macromolecule modificationGO:00434121110.016
regulation of protein bindingGO:004339330.016
cytokinesisGO:000091030.016
regulation of synapse organizationGO:005080730.016
regulation of cell differentiationGO:00455951420.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
neuroblast proliferationGO:000740520.016
immune system developmentGO:00025201910.016
protein secretionGO:000930610.016
cellular localizationGO:0051641970.016
Mouse
hormone secretionGO:004687920.016
positive regulation of protein complex assemblyGO:003133420.015
phosphate containing compound metabolic processGO:00067961080.015
cell deathGO:00082191210.015
regulation of protein catabolic processGO:004217610.015
post embryonic organ developmentGO:004856940.015
regulation of anatomical structure morphogenesisGO:00226031300.015
regulation of synaptic plasticityGO:004816710.015
internal peptidyl lysine acetylationGO:001839320.015
protein dephosphorylationGO:000647030.015
ameboidal type cell migrationGO:00016671430.015
negative regulation of epithelial cell proliferationGO:005068010.015
notochord developmentGO:0030903540.015
growthGO:00400071740.015
somite developmentGO:0061053960.015
epithelial tube morphogenesisGO:00605621480.015
cellular response to starvationGO:000926710.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
erk1 and erk2 cascadeGO:007037140.015
lymphocyte proliferationGO:004665110.015
developmental growthGO:00485891660.015
cellular response to chemical stimulusGO:00708871570.015
production of molecular mediator of immune responseGO:000244020.015
antimicrobial humoral responseGO:001973020.015
regulation of nucleoside metabolic processGO:000911820.015
cellular protein modification processGO:00064641000.015
negative regulation of signal transductionGO:0009968940.014
regulation of jak stat cascadeGO:004642530.014
positive regulation of metabolic processGO:00098931080.014
protein acylationGO:004354330.014
apoptotic processGO:00069151160.014
b cell activationGO:004211320.014
positive regulation of epithelial cell proliferationGO:005067910.014
fin developmentGO:0033333770.014
cellular component biogenesisGO:00440851780.014
cellular response to organic substanceGO:00713101050.014
negative regulation of intracellular transportGO:003238730.014
muscle organ developmentGO:00075171010.014
negative regulation of macromolecule metabolic processGO:0010605760.014
hematopoietic or lymphoid organ developmentGO:00485341910.014
ribonucleoside monophosphate catabolic processGO:000915840.014
deathGO:00162651210.014
actin filament based movementGO:003004810.014
response to corticosteroidGO:003196010.014
negative regulation of nucleocytoplasmic transportGO:004682320.014
appendage developmentGO:0048736800.014
atp catabolic processGO:000620040.014
cilium assemblyGO:0042384580.014
response to nutrientGO:000758430.014
regulation of apoptotic processGO:0042981980.014
regulation of nucleotide catabolic processGO:003081120.013
negative regulation of nitrogen compound metabolic processGO:0051172590.013
actin polymerization or depolymerizationGO:000815420.013
positive regulation of cytoskeleton organizationGO:005149530.013
mesenchymal cell differentiationGO:0048762870.013
rna localizationGO:000640340.013
cellular component disassemblyGO:002241110.013
cellular component assemblyGO:00226071700.013
single organism membrane fusionGO:004480120.013
tissue remodelingGO:004877140.013
multicellular organismal response to stressGO:003355520.013
response to glucocorticoidGO:005138410.013
cortical cytoskeleton organizationGO:003086510.013
regulation of hormone secretionGO:004688320.013
endosomal transportGO:001619720.013
response to uvGO:000941130.013
membrane fusionGO:006102520.013
skeletal muscle tissue developmentGO:0007519670.013
negative regulation of protein serine threonine kinase activityGO:007190120.013
neurotransmitter secretionGO:000726920.013
cellular response to oxygen levelsGO:007145310.013
intracellular signal transductionGO:0035556850.013
lateral inhibitionGO:004633110.013
programmed cell deathGO:00125011190.013
development of primary female sexual characteristicsGO:004654540.013
muscle tissue developmentGO:00605371100.013
negative regulation of cytoplasmic transportGO:190365020.013
membrane invaginationGO:001032410.013
negative regulation of metabolic processGO:0009892860.013
cellular response to nutrient levelsGO:003166920.013
inner ear morphogenesisGO:0042472630.013
regulation of mrna processingGO:005068430.013
embryonic viscerocranium morphogenesisGO:0048703520.013
cell fate commitmentGO:0045165990.012
cell fate specificationGO:0001708680.012
female gonad developmentGO:000858540.012
negative regulation of intracellular protein transportGO:009031730.012
female sex differentiationGO:004666040.012
embryonic heart tube developmentGO:00350501330.012
synaptic vesicle localizationGO:009747910.012
mesoderm developmentGO:0007498880.012
sprouting angiogenesisGO:0002040530.012
organelle fusionGO:004828430.012
regulation of neurogenesisGO:0050767870.012
positive regulation of purine nucleotide catabolic processGO:003312310.012
meiotic cell cycle processGO:190304630.012
positive regulation of nucleoside metabolic processGO:004597910.012
positive regulation of epithelial cell differentiationGO:003085820.012
positive regulation of macromolecule metabolic processGO:0010604930.012
response to woundingGO:00096111160.012
heart morphogenesisGO:00030071560.012
nucleoside monophosphate catabolic processGO:000912540.012
chemotaxisGO:00069351040.012
startle responseGO:000196440.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
cellular amide metabolic processGO:004360340.012
negative regulation of mapk cascadeGO:004340940.012
positive regulation of map kinase activityGO:004340630.012
protein stabilizationGO:005082120.012
regulation of gtp catabolic processGO:003312420.012
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.012
sensory perception of painGO:001923310.012
synaptic vesicle transportGO:004848910.012
transmembrane transportGO:00550851200.012
myeloid cell differentiationGO:0030099860.012
regulation of protein ubiquitinationGO:003139630.012
embryonic heart tube morphogenesisGO:00031431080.012
regulation of sequestering of calcium ionGO:005128240.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
protein homooligomerizationGO:005126030.012
retina morphogenesis in camera type eyeGO:0060042790.012
somatic stem cell maintenanceGO:003501910.012
regulation of cell developmentGO:00602841000.012
striated muscle tissue developmentGO:00147061100.012
regulation of stem cell differentiationGO:200073640.012
peptidyl serine modificationGO:001820920.012
negative regulation of response to stimulusGO:00485851040.012
negative regulation of reproductive processGO:200024230.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
behaviorGO:0007610740.012
Zebrafish
taxisGO:00423301090.012
establishment of synaptic vesicle localizationGO:009748010.012
organelle localizationGO:0051640490.012
regulation of dna replicationGO:000627530.012
regulation of cell deathGO:00109411030.012
regulation of gtpase activityGO:004308720.012
negative regulation of cytokine productionGO:000181810.012
regulation of cell substrate adhesionGO:001081010.011
regulation of nervous system developmentGO:0051960900.011
protein polymerizationGO:005125840.011
stem cell differentiationGO:00488631170.011
olfactory lobe developmentGO:002198840.011
regulation of transporter activityGO:003240920.011
regulation of calcium ion transportGO:005192420.011
small molecule catabolic processGO:004428230.011
determination of heart left right asymmetryGO:00613711170.011
purine ribonucleoside monophosphate catabolic processGO:000916940.011
cellular response to radiationGO:007147840.011
response to other organismGO:0051707970.011
interspecies interaction between organismsGO:004441940.011
cellular response to reactive oxygen speciesGO:003461420.011
enzyme linked receptor protein signaling pathwayGO:00071671060.011
negative regulation of defense responseGO:003134820.011
cartilage developmentGO:0051216960.011
central nervous system neuron differentiationGO:0021953740.011
stem cell divisionGO:001714510.011
zymogen activationGO:003163830.011
sequestering of calcium ionGO:005120830.011
positive regulation of gtp catabolic processGO:003312610.011
phagocytosis engulfmentGO:000691110.011
single fertilizationGO:000733830.011
symbiosis encompassing mutualism through parasitismGO:004440340.011
sensory perception of chemical stimulusGO:000760630.011
neurological system processGO:0050877620.011
Zebrafish
g1 s transition of mitotic cell cycleGO:000008210.011
cellular response to decreased oxygen levelsGO:003629410.011
regulation of protein polymerizationGO:003227120.011
regulation of cellular protein catabolic processGO:190336210.011
negative regulation of cell communicationGO:0010648960.011
golgi vesicle transportGO:004819330.011
connective tissue developmentGO:0061448990.011
neural crest cell differentiationGO:0014033720.011
embryonic hemopoiesisGO:0035162530.011
regulation of production of molecular mediator of immune responseGO:000270010.011
regulation of sodium ion transportGO:000202820.011
regulation of localizationGO:00328791040.011
Mouse
purine nucleoside monophosphate catabolic processGO:000912840.011
i kappab kinase nf kappab signalingGO:000724940.011
regulation of exocytosisGO:001715710.011
Mouse
negative regulation of protein localization to nucleusGO:190018120.011
positive regulation of gtpase activityGO:004354710.011
somatic muscle developmentGO:000752540.011
negative regulation of signalingGO:0023057960.011
positive regulation of nucleotide catabolic processGO:003081310.011
peptidyl threonine phosphorylationGO:001810710.011
cellular carbohydrate metabolic processGO:004426240.011
response to external biotic stimulusGO:0043207970.011
pigmentationGO:0043473850.011
regulation of endothelial cell proliferationGO:000193610.011
b cell differentiationGO:003018310.011
nuclear migrationGO:000709730.011
regulation of blood pressureGO:000821710.011
peptidyl threonine modificationGO:001821010.011
regulation of neuron differentiationGO:0045664560.011
forebrain developmentGO:0030900960.011
regulation of meiotic cell cycleGO:005144510.011
cell cycle g1 s phase transitionGO:004484310.010
cytosolic calcium ion transportGO:006040130.010
regulation of cell projection assemblyGO:006049140.010
negative regulation of protein import into nucleusGO:004230820.010
response to biotic stimulusGO:0009607970.010
regulation of ion transmembrane transporter activityGO:003241220.010
negative regulation of cellular catabolic processGO:003133030.010
regulation of circadian rhythmGO:004275240.010
positive regulation of nucleobase containing compound metabolic processGO:0045935690.010
establishment of protein localization to plasma membraneGO:009000210.010
microtubule organizing center organizationGO:003102310.010
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.010
phosphorus metabolic processGO:00067931090.010
wnt signaling pathwayGO:0016055800.010
cellular component assembly involved in morphogenesisGO:00109271070.010

lgi3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.038
cancerDOID:16200.018
disease of cellular proliferationDOID:1456600.018
organ system cancerDOID:005068600.018
nervous system diseaseDOID:86300.017
disease of metabolismDOID:001466700.016
musculoskeletal system diseaseDOID:1700.016
immune system diseaseDOID:291400.015
cardiovascular system diseaseDOID:128700.012
sensory system diseaseDOID:005015500.010