Danio rerio

22 known processes

ca8

carbonic anhydrase VIII

(Aliases: zgc:110118)

ca8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular biosynthetic processGO:00442492860.850
cell motilityGO:00488702440.723
response to stressGO:00069502630.614
Zebrafish
aromatic compound biosynthetic processGO:00194382170.571
biosynthetic processGO:00090582940.479
positive regulation of metabolic processGO:00098931080.471
organic cyclic compound metabolic processGO:19013603010.453
nucleobase containing compound biosynthetic processGO:00346542050.446
regulation of macromolecule biosynthetic processGO:00105562250.432
cellular nitrogen compound biosynthetic processGO:00442712180.422
agingGO:000756820.406
organic substance biosynthetic processGO:19015762890.399
digestive tract developmentGO:00485652650.381
immune system processGO:00023762410.370
response to woundingGO:00096111160.369
homeostatic processGO:00425921420.367
Zebrafish
tube morphogenesisGO:00352393490.363
localization of cellGO:00516742440.348
central nervous system developmentGO:00074173870.346
single organism transportGO:00447652060.325
Zebrafish
regulation of primary metabolic processGO:00800903110.322
cellular nitrogen compound metabolic processGO:00346412900.320
locomotionGO:00400113130.317
single organism biosynthetic processGO:0044711710.303
cell deathGO:00082191210.297
regulation of biological qualityGO:00650082630.289
Zebrafish
negative regulation of cellular processGO:00485232830.279
positive regulation of macromolecule metabolic processGO:0010604930.274
cellular macromolecule metabolic processGO:00442603910.253
regulation of developmental processGO:00507932470.252
deathGO:00162651210.247
programmed cell deathGO:00125011190.245
vasculature developmentGO:00019442780.244
positive regulation of nitrogen compound metabolic processGO:0051173690.239
blood vessel morphogenesisGO:00485142160.234
regulation of response to stimulusGO:00485832690.229
cell projection organizationGO:00300302840.228
apoptotic processGO:00069151160.222
single organism localizationGO:19025782250.219
Zebrafish
regulation of metabolic processGO:00192223590.210
regulation of multicellular organismal processGO:00512392770.209
cell migrationGO:00164772370.209
regulation of cellular macromolecule biosynthetic processGO:20001122220.206
organic cyclic compound biosynthetic processGO:19013622230.203
heart developmentGO:00075073130.199
regulation of nucleobase containing compound metabolic processGO:00192192500.197
hindbrain developmentGO:0030902910.196
heterocycle biosynthetic processGO:00181302150.196
response to nutrientGO:000758430.190
regulation of cellular metabolic processGO:00313233200.183
transportGO:00068102200.172
Zebrafish
regulation of gene expressionGO:00104682650.170
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.169
neural precursor cell proliferationGO:0061351200.165
regulation of cell communicationGO:00106462320.159
regulation of multicellular organismal developmentGO:20000262230.159
nitric oxide metabolic processGO:004620920.158
blood vessel developmentGO:00015682460.157
pigmentationGO:0043473850.151
enzyme linked receptor protein signaling pathwayGO:00071671060.149
intracellular signal transductionGO:0035556850.148
Mouse
response to chemicalGO:00422213200.145
Zebrafish
regulation of cell deathGO:00109411030.144
signal transductionGO:00071654550.139
Mouse
negative regulation of programmed cell deathGO:0043069580.138
morphogenesis of an epitheliumGO:00020093330.136
regulation of cellular biosynthetic processGO:00313262450.136
nucleobase containing compound metabolic processGO:00061392740.135
positive regulation of cell adhesionGO:004578510.130
regulation of apoptotic processGO:0042981980.130
regulation of transcription dna templatedGO:00063552130.128
regulation of rna biosynthetic processGO:20011412130.125
macromolecule biosynthetic processGO:00090592270.123
immune system developmentGO:00025201910.123
response to external stimulusGO:00096052640.122
regulation of nitrogen compound metabolic processGO:00511712510.118
cellular response to decreased oxygen levelsGO:003629410.116
generation of neuronsGO:00486993850.115
maintenance of locationGO:005123540.115
myeloid cell homeostasisGO:0002262560.114
cellular aromatic compound metabolic processGO:00067252950.114
positive regulation of cellular metabolic processGO:0031325940.114
gene expressionGO:00104672520.112
regulation of multicellular organism growthGO:004001440.109
transcription from rna polymerase ii promoterGO:0006366800.108
gland developmentGO:00487321430.108
head developmentGO:00603223030.107
behaviorGO:0007610740.105
reactive nitrogen species metabolic processGO:200105700.105
positive regulation of nucleobase containing compound metabolic processGO:0045935690.104
androgen metabolic processGO:000820920.104
ear developmentGO:00435831270.104
organonitrogen compound metabolic processGO:1901564740.103
cell surface receptor signaling pathwayGO:00071663250.100
chordate embryonic developmentGO:00430092710.100
regulation of signalingGO:00230512350.098
small molecule metabolic processGO:0044281770.098
response to decreased oxygen levelsGO:0036293250.098
regulation of cell differentiationGO:00455951420.098
establishment of localizationGO:00512342440.098
Zebrafish
cellular component movementGO:00069283350.098
regulation of signal transductionGO:00099662250.097
modulation by virus of host morphology or physiologyGO:001904810.096
angiogenesisGO:00015251580.096
negative regulation of biological processGO:00485193040.096
growthGO:00400071740.096
embryonic heart tube developmentGO:00350501330.096
transmembrane transportGO:00550851200.095
Zebrafish
ion transportGO:00068111140.092
Zebrafish
nucleic acid metabolic processGO:00903042440.091
skeletal system developmentGO:00015011810.088
gastrulationGO:00073692080.088
fatty acid biosynthetic processGO:000663340.087
sensory organ developmentGO:00074233930.086
regulation of macromolecule metabolic processGO:00602553170.084
embryonic organ developmentGO:00485683810.083
regulation of carbohydrate metabolic processGO:000610940.081
nucleoside phosphate biosynthetic processGO:1901293210.081
nitric oxide biosynthetic processGO:000680920.081
larval developmentGO:000216420.080
response to hypoxiaGO:0001666250.078
response to organic substanceGO:00100331530.077
hematopoietic or lymphoid organ developmentGO:00485341910.077
multicellular organism growthGO:003526440.077
carboxylic acid metabolic processGO:0019752220.076
brain developmentGO:00074202930.076
negative regulation of cell deathGO:0060548600.075
chemical homeostasisGO:0048878490.075
Zebrafish
cation homeostasisGO:0055080330.075
Zebrafish
cellular carbohydrate metabolic processGO:004426240.072
organelle organizationGO:00069962270.072
regulation of rna metabolic processGO:00512522240.071
nitrogen compound metabolic processGO:00068073190.070
response to ketoneGO:190165410.070
positive regulation of cellular biosynthetic processGO:0031328680.070
female sex differentiationGO:004666040.070
negative regulation of response to stimulusGO:00485851040.066
cellular response to chemical stimulusGO:00708871570.065
Zebrafish
erythrocyte differentiationGO:0030218540.065
positive regulation of cellular amino acid metabolic processGO:004576400.063
vasculogenesisGO:0001570410.062
sensory system developmentGO:0048880760.062
cellular localizationGO:0051641970.062
cellular macromolecule biosynthetic processGO:00346452240.061
heterocycle metabolic processGO:00464832900.061
mitotic cell cycle processGO:1903047480.060
negative regulation of catabolic processGO:000989530.060
regulation of nucleic acid templated transcriptionGO:19035062130.060
appendage morphogenesisGO:0035107560.059
cellular response to organic substanceGO:00713101050.057
interaction with hostGO:005170140.057
cellular amine metabolic processGO:004410620.056
cell cycleGO:0007049930.056
digestive system developmentGO:00551232890.056
regulation of cellular carbohydrate metabolic processGO:001067540.055
digestive tract morphogenesisGO:00485462310.054
sensory perceptionGO:0007600390.054
cellular cation homeostasisGO:0030003170.053
peptidyl serine modificationGO:001820920.052
stem cell differentiationGO:00488631170.052
positive regulation of cellular amine metabolic processGO:003324000.052
positive regulation of transportGO:005105020.052
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.051
lipid metabolic processGO:0006629520.051
regulation of neurogenesisGO:0050767870.050
regulation of programmed cell deathGO:00430671010.050
embryonic organ morphogenesisGO:00485622740.050
positive regulation of biological processGO:00485182530.050
sexual reproductionGO:0019953360.049
regulation of cellular ketone metabolic processGO:001056570.049
retina morphogenesis in camera type eyeGO:0060042790.048
phosphorus metabolic processGO:00067931090.048
lipid storageGO:001991510.048
organonitrogen compound biosynthetic processGO:1901566470.048
hemopoiesisGO:00300971830.048
long chain fatty acid metabolic processGO:000167610.047
regulation of i kappab kinase nf kappab signalingGO:004312240.047
developmental growthGO:00485891660.047
cognitionGO:005089010.046
embryonic viscerocranium morphogenesisGO:0048703520.046
response to alcoholGO:0097305140.045
erk1 and erk2 cascadeGO:007037140.045
lipid homeostasisGO:005508830.045
regulation of biosynthetic processGO:00098892500.045
regulation of transcription from rna polymerase ii promoterGO:00063571140.044
cellular response to endogenous stimulusGO:0071495680.043
negative regulation of apoptotic processGO:0043066550.042
regulation of cellular amino acid metabolic processGO:000652100.042
regulation of metal ion transportGO:001095940.042
transcription dna templatedGO:00063511810.041
epithelial tube morphogenesisGO:00605621480.041
cellular response to oxygen levelsGO:007145310.041
system processGO:00030081850.041
response to endogenous stimulusGO:0009719830.041
positive regulation of biosynthetic processGO:0009891680.041
cellular component assembly involved in morphogenesisGO:00109271070.040
embryonic hemopoiesisGO:0035162530.040
positive regulation of catalytic activityGO:0043085250.040
organophosphate biosynthetic processGO:0090407230.040
eye developmentGO:00016542770.039
specification of symmetryGO:00097992040.039
cell proliferationGO:0008283800.039
rna biosynthetic processGO:00327741810.039
response to alkaloidGO:004327920.038
carbohydrate metabolic processGO:0005975120.038
response to glucocorticoidGO:005138410.038
inflammatory responseGO:000695480.038
mitotic cell cycleGO:0000278640.038
purine ribonucleotide metabolic processGO:0009150270.037
reactive oxygen species metabolic processGO:007259360.037
lateral line developmentGO:0048882660.036
endothelium developmentGO:0003158250.036
regulation of cell activationGO:005086510.035
positive regulation of catabolic processGO:000989640.035
amine metabolic processGO:000930820.035
ribonucleotide metabolic processGO:0009259270.035
cellular lipid metabolic processGO:0044255360.035
muscle cell developmentGO:00550011150.035
regulation of intracellular signal transductionGO:1902531570.035
positive regulation of macromolecule biosynthetic processGO:0010557590.035
inorganic ion transmembrane transportGO:0098660570.034
Zebrafish
viral processGO:001603210.034
oxoacid metabolic processGO:0043436310.034
metal ion homeostasisGO:0055065260.034
positive regulation of rna metabolic processGO:0051254590.034
peptidyl serine phosphorylationGO:001810510.034
central nervous system neuron differentiationGO:0021953740.034
insulin like growth factor receptor signaling pathwayGO:004800940.033
cell proliferation in forebrainGO:002184630.033
regulation of biomineral tissue developmentGO:007016720.033
response to transition metal nanoparticleGO:1990267280.033
regulation of tube sizeGO:003515020.032
response to extracellular stimulusGO:0009991100.032
regulation of peptidyl tyrosine phosphorylationGO:005073010.032
membrane lipid biosynthetic processGO:004646720.032
multi organism cellular processGO:004476420.032
sensory organ morphogenesisGO:00905962000.032
defense responseGO:0006952470.032
regenerationGO:0031099910.031
positive regulation of erk1 and erk2 cascadeGO:007037420.031
organic acid metabolic processGO:0006082310.031
camp biosynthetic processGO:0006171110.031
ovulation cycleGO:004269820.031
regulation of cellular amine metabolic processGO:003323800.031
positive regulation of lipase activityGO:006019310.031
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messengerGO:000718750.031
neurological system processGO:0050877620.030
regulation of localizationGO:00328791040.030
rna metabolic processGO:00160702190.030
positive regulation of transcription dna templatedGO:0045893570.030
cell cycle g1 s phase transitionGO:004484310.030
epithelial cell differentiationGO:00308551160.030
response to monosaccharideGO:003428430.030
determination of bilateral symmetryGO:00098552040.029
response to hormoneGO:0009725480.029
neuromast developmentGO:0048884460.029
nucleic acid templated transcriptionGO:00976591810.029
regulation of sodium ion transportGO:000202820.029
cell morphogenesis involved in differentiationGO:00009041950.029
organelle assemblyGO:00709251100.029
reactive oxygen species biosynthetic processGO:190340910.028
regulation of neuron differentiationGO:0045664560.028
protein metabolic processGO:00195381830.028
regulation of protein localization to nucleusGO:190018020.028
glucose importGO:004632320.027
ion transmembrane transportGO:0034220910.027
Zebrafish
response to acid chemicalGO:0001101170.027
lateral line system developmentGO:0048925760.027
regulation of inflammatory responseGO:005072720.027
mesoderm developmentGO:0007498880.027
cellular response to hypoxiaGO:007145610.027
cellular ketone metabolic processGO:0042180110.026
regulation of nervous system developmentGO:0051960900.026
retina development in camera type eyeGO:00600411460.026
nucleocytoplasmic transportGO:000691340.026
negative regulation of defense responseGO:003134820.026
establishment of localization in cellGO:0051649770.026
g protein coupled receptor signaling pathwayGO:0007186740.026
single organism metabolic processGO:00447102170.025
negative regulation of signal transductionGO:0009968940.025
determination of left right symmetryGO:00073681790.025
organic anion transportGO:0015711150.025
cellular response to stressGO:0033554620.025
peptide transportGO:001583310.025
multi organism processGO:00517041340.025
cyclic purine nucleotide metabolic processGO:0052652180.025
cellular response to organic cyclic compoundGO:0071407380.025
regulation of erk1 and erk2 cascadeGO:007037240.025
embryonic heart tube morphogenesisGO:00031431080.025
cell morphogenesisGO:00009022890.024
response to corticosteroidGO:003196010.024
multi organism reproductive processGO:0044703360.024
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.024
response to vitaminGO:003327330.024
symbiosis encompassing mutualism through parasitismGO:004440340.024
positive regulation of cell differentiationGO:0045597300.024
sensory perception of painGO:001923310.023
taurine metabolic processGO:001953010.023
organic substance transportGO:0071702580.023
Zebrafish
response to xenobiotic stimulusGO:0009410450.023
Zebrafish
anion transportGO:0006820380.023
response to lipidGO:0033993600.023
ameboidal type cell migrationGO:00016671430.022
response to organic cyclic compoundGO:0014070510.022
adult behaviorGO:003053420.022
protein import into nucleusGO:000660630.022
cellular homeostasisGO:0019725260.022
inner ear developmentGO:00488391260.022
negative regulation of cellular catabolic processGO:003133030.021
intrinsic apoptotic signaling pathwayGO:0097193200.021
regulation of cell migrationGO:0030334400.021
neuron developmentGO:00486662620.021
protein localization to nucleusGO:003450430.021
cardiocyte differentiationGO:0035051440.021
inorganic anion transportGO:0015698250.021
taxisGO:00423301090.021
sphingolipid biosynthetic processGO:003014820.021
regulation of cellular component organizationGO:0051128860.020
protein importGO:001703830.020
stem cell proliferationGO:007208940.020
hormone transportGO:000991420.020
heart morphogenesisGO:00030071560.020
mononuclear cell proliferationGO:003294310.020
development of primary female sexual characteristicsGO:004654540.020
cellular amino acid metabolic processGO:000652070.020
regulation of transportGO:0051049450.020
multicellular organismal metabolic processGO:004423620.020
regulation of dna replicationGO:000627530.020
g1 s transition of mitotic cell cycleGO:000008210.020
purine nucleotide metabolic processGO:0006163270.020
negative regulation of metabolic processGO:0009892860.020
positive regulation of nucleic acid templated transcriptionGO:1903508570.020
sensory perception of smellGO:000760820.019
extracellular matrix assemblyGO:008502910.019
positive regulation of cell communicationGO:0010647560.019
epidermis developmentGO:0008544480.019
negative regulation of blood circulationGO:190352320.019
cell activationGO:0001775160.019
blood circulationGO:0008015870.019
regulation of growth rateGO:004000910.019
cartilage developmentGO:0051216960.019
monocarboxylic acid biosynthetic processGO:0072330120.018
organophosphate metabolic processGO:0019637370.018
autophagyGO:000691440.018
regulation of stem cell proliferationGO:007209120.018
protein targeting to nucleusGO:004474430.018
cation transmembrane transportGO:0098655650.018
Zebrafish
positive regulation of developmental processGO:0051094500.018
connective tissue developmentGO:0061448990.018
regulation of gtp catabolic processGO:003312420.017
nucleobase containing small molecule metabolic processGO:0055086320.017
endothelial cell developmentGO:0001885120.017
nuclear transportGO:005116940.017
negative regulation of striated muscle tissue developmentGO:004584320.017
hepaticobiliary system developmentGO:0061008980.017
lipid biosynthetic processGO:0008610220.017
phosphate containing compound metabolic processGO:00067961080.017
carbohydrate derivative biosynthetic processGO:1901137430.017
regulation of establishment of protein localizationGO:007020140.017
regulation of nucleoside metabolic processGO:000911820.017
regulation of cytokine productionGO:000181730.016
cellular ion homeostasisGO:0006873170.016
calcium ion homeostasisGO:0055074190.016
regulation of cellular component movementGO:0051270550.016
positive regulation of carbohydrate metabolic processGO:004591310.016
striated muscle cell developmentGO:00550021080.016
negative regulation of gene expressionGO:0010629650.016
cellular response to nutrient levelsGO:003166920.016
positive regulation of i kappab kinase nf kappab signalingGO:004312330.016
guanosine containing compound metabolic processGO:190106840.016
macromolecule localizationGO:0033036540.016
alpha amino acid metabolic processGO:190160530.016
regulation of cell developmentGO:00602841000.016
erythrocyte homeostasisGO:0034101550.016
reproductive processGO:0022414400.016
single organism organelle organizationGO:19025891990.016
modification of morphology or physiology of other organismGO:003582140.016
multicellular organism reproductionGO:0032504350.016
negative regulation of signalingGO:0023057960.015
positive regulation of secretionGO:005104710.015
single organism nuclear importGO:190259330.015
positive regulation of cell substrate adhesionGO:001081110.015
cellular response to hormone stimulusGO:0032870390.015
regulation of cell motilityGO:2000145460.015
estrogen metabolic processGO:000821020.015
positive regulation of cell cycleGO:004578730.015
fin developmentGO:0033333770.015
endothelial cell differentiationGO:0045446200.015
ovulation cycle processGO:002260220.015
positive regulation of cell divisionGO:005178120.015
divalent inorganic cation homeostasisGO:0072507220.015
reproductionGO:0000003400.015
i kappab kinase nf kappab signalingGO:000724940.015
positive regulation of response to stimulusGO:0048584800.014
response to ethanolGO:004547160.014
carbohydrate derivative metabolic processGO:1901135610.014
regulation of hormone secretionGO:004688320.014
dicarboxylic acid metabolic processGO:004364810.014
positive regulation of phosphorus metabolic processGO:0010562210.014
cyclic nucleotide metabolic processGO:0009187180.014
lymphocyte proliferationGO:004665110.014
neuron differentiationGO:00301823530.014
purine nucleotide biosynthetic processGO:0006164200.014
positive regulation of multicellular organismal processGO:0051240520.014
ion homeostasisGO:0050801410.014
Zebrafish
nuclear importGO:005117030.014
positive regulation of gene expressionGO:0010628710.014
leukocyte activationGO:0045321120.014
negative regulation of muscle tissue developmentGO:190186220.014
positive regulation of cytokine productionGO:000181920.014
purine containing compound metabolic processGO:0072521290.014
multicellular organismal response to stressGO:003355520.013
long chain fatty acid biosynthetic processGO:004275910.013
camera type eye developmentGO:00430102220.013
regulation of blood vessel sizeGO:005088020.013
positive regulation of secretion by cellGO:190353210.013
negative regulation of cell communicationGO:0010648960.013
muscle system processGO:0003012200.013
negative regulation of heart contractionGO:004582220.013
cellular component biogenesisGO:00440851780.013
purine containing compound biosynthetic processGO:0072522200.013
embryo development ending in birth or egg hatchingGO:00097922710.013
fatty acid transportGO:001590810.013
b cell activationGO:004211320.013
regulation of cellular phGO:003064110.013
regulation of cytoplasmic transportGO:190364940.013
liver developmentGO:0001889960.013
proepicardium developmentGO:000334240.013
regulation of autophagyGO:001050630.013
regulation of behaviorGO:0050795240.012
toll like receptor signaling pathwayGO:000222440.012
dna templated transcription initiationGO:000635210.012
circulatory system processGO:0003013870.012
cellular response to extracellular stimulusGO:003166820.012
neuroblast proliferationGO:000740520.012
stem cell developmentGO:0048864820.012
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.012
cellular response to xenobiotic stimulusGO:0071466350.012
Zebrafish
response to steroid hormoneGO:0048545350.012
ceramide biosynthetic processGO:004651310.012
regulation of cell proliferationGO:0042127370.012
inorganic cation transmembrane transportGO:0098662500.012
Zebrafish
neuromuscular process controlling balanceGO:005088530.012
regulation of phGO:000688530.012
Zebrafish
positive regulation of cellular catabolic processGO:003133130.012
positive regulation of jak stat cascadeGO:004642720.012
chemotaxisGO:00069351040.012
somatic muscle developmentGO:000752540.012
cellular metal ion homeostasisGO:0006875160.012
oxidation reduction processGO:0055114410.012
positive regulation of rna biosynthetic processGO:1902680570.012
actin filament based processGO:0030029640.012
inositol lipid mediated signalingGO:004801720.012
Mouse
positive regulation of stem cell proliferationGO:200064810.012
response to oxygen levelsGO:0070482250.012
regulation of locomotionGO:0040012550.012
cellular response to lipidGO:0071396390.012
hatchingGO:003518840.012
response to foodGO:003209410.011
interspecies interaction between organismsGO:004441940.011
regulation of cell cycleGO:0051726520.011
negative regulation of protein kinase b signalingGO:005189820.011
adenylate cyclase modulating g protein coupled receptor signaling pathwayGO:000718850.011
gtp metabolic processGO:004603940.011
smooth muscle contractionGO:000693920.011
wound healingGO:0042060900.011
glycerolipid biosynthetic processGO:004501710.011
response to metal ionGO:0010038340.011
negative regulation of macromolecule metabolic processGO:0010605760.011
positive regulation of protein kinase b signalingGO:005189710.011
regulation of cell migration involved in sprouting angiogenesisGO:009004930.011
neuron projection morphogenesisGO:00488121610.011
regulation of calcium ion transportGO:005192420.011
response to estradiolGO:003235560.011
response to oxygen containing compoundGO:1901700550.011
hormone secretionGO:004687920.011
skin developmentGO:0043588540.011
purine ribonucleotide biosynthetic processGO:0009152200.011
positive regulation of epithelial cell differentiationGO:003085820.011
neuromast hair cell differentiationGO:0048886120.011
regulation of cellular localizationGO:0060341120.011
carbohydrate homeostasisGO:003350010.011
regulation of protein transportGO:005122330.011
response to glucoseGO:000974930.011
cation transportGO:0006812810.011
Zebrafish
chloride transportGO:000682180.011
sulfur compound transportGO:007234830.011
regulation of response to oxidative stressGO:190288220.011
organic acid transportGO:001584990.011
epibolyGO:0090504410.010

ca8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.074
cardiovascular system diseaseDOID:128700.032
nervous system diseaseDOID:86300.028
eye and adnexa diseaseDOID:149200.014
retinal diseaseDOID:567900.014
eye diseaseDOID:561400.014
sensory system diseaseDOID:005015500.014
retinal degenerationDOID:846600.013