Danio rerio

0 known processes

plk4

polo-like kinase 4 (Drosophila)

(Aliases: stk18,wu:fi33g07)

plk4 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular component morphogenesisGO:00329893360.434
Fly
cell morphogenesisGO:00009022890.431
Fly
cell projection organizationGO:00300302840.412
Fly
nucleobase containing compound biosynthetic processGO:00346542050.365
regulation of transcription dna templatedGO:00063552130.358
negative regulation of biological processGO:00485193040.334
cellular nitrogen compound biosynthetic processGO:00442712180.324
nucleoside monophosphate catabolic processGO:000912540.320
nitrogen compound metabolic processGO:00068073190.301
microtubule organizing center organizationGO:003102310.276
Human Mouse Fly
cell projection morphogenesisGO:00488582440.255
Fly
nucleic acid metabolic processGO:00903042440.255
generation of neuronsGO:00486993850.253
aromatic compound biosynthetic processGO:00194382170.246
cell part morphogenesisGO:00329902460.245
Fly
organelle organizationGO:00069962270.245
Human Mouse Fly
rna biosynthetic processGO:00327741810.238
meiotic nuclear divisionGO:000712640.228
Fly
heterocycle biosynthetic processGO:00181302150.227
heterocycle metabolic processGO:00464832900.206
meiosis iiGO:000713510.202
biosynthetic processGO:00090582940.189
single organism organelle organizationGO:19025891990.173
Human Mouse Fly
macromolecule biosynthetic processGO:00090592270.169
positive regulation of cellular metabolic processGO:0031325940.167
organic cyclic compound biosynthetic processGO:19013622230.167
regulation of metabolic processGO:00192223590.167
Fly
meiotic chromosome segregationGO:004513230.163
locomotionGO:00400113130.155
cellular aromatic compound metabolic processGO:00067252950.154
transportGO:00068102200.149
cilium morphogenesisGO:0060271850.142
Fly
purine ribonucleoside monophosphate catabolic processGO:000916940.142
regulation of biological qualityGO:00650082630.141
Fly
nuclear transportGO:005116940.139
centrosome organizationGO:005129710.136
Human Mouse Fly
regulation of macromolecule metabolic processGO:00602553170.135
Fly
neuron differentiationGO:00301823530.134
cellular macromolecule metabolic processGO:00442603910.131
Human Mouse Fly
transcription dna templatedGO:00063511810.129
regulation of rna biosynthetic processGO:20011412130.128
regulation of protein complex assemblyGO:004325430.128
spindle assembly involved in mitosisGO:009030710.127
larval developmentGO:000216420.122
purine nucleoside monophosphate catabolic processGO:000912840.119
microtubule based movementGO:0007018330.118
cell morphogenesis involved in differentiationGO:00009041950.113
cellular nitrogen compound metabolic processGO:00346412900.112
cellular macromolecule biosynthetic processGO:00346452240.111
atp catabolic processGO:000620040.110
neuron projection developmentGO:00311751800.107
rna metabolic processGO:00160702190.103
regulation of nucleic acid templated transcriptionGO:19035062130.103
multicellular organism growthGO:003526440.102
positive regulation of nitrogen compound metabolic processGO:0051173690.100
establishment of protein localization to organelleGO:007259440.098
nucleic acid templated transcriptionGO:00976591810.098
regulation of primary metabolic processGO:00800903110.097
Fly
meiotic cell cycle processGO:190304630.093
regulation of macromolecule biosynthetic processGO:00105562250.093
cell migrationGO:00164772370.091
regulation of rna metabolic processGO:00512522240.089
organic cyclic compound metabolic processGO:19013603010.088
macromolecular complex subunit organizationGO:0043933740.087
Fly
hematopoietic or lymphoid organ developmentGO:00485341910.084
regulation of establishment of protein localizationGO:007020140.084
morphogenesis of an epitheliumGO:00020093330.081
determination of bilateral symmetryGO:00098552040.081
regulation of protein transportGO:005122330.080
regulation of gene expressionGO:00104682650.080
Fly
neuron developmentGO:00486662620.080
chromosome organizationGO:0051276310.078
chromosome organization involved in meiosisGO:007019210.077
positive regulation of cellular processGO:00485222010.077
Human
centrosome duplicationGO:005129810.077
Human Mouse Fly
maintenance of locationGO:005123540.077
gene expressionGO:00104672520.076
Fly
cellular biosynthetic processGO:00442492860.076
establishment of localizationGO:00512342440.075
localization of cellGO:00516742440.074
regulation of biosynthetic processGO:00098892500.073
nucleobase containing compound metabolic processGO:00061392740.073
meiosis iGO:000712710.072
regulation of nitrogen compound metabolic processGO:00511712510.072
regulation of cellular metabolic processGO:00313233200.071
single organism metabolic processGO:00447102170.068
transcription from rna polymerase ii promoterGO:0006366800.067
sister chromatid segregationGO:000081960.066
retina morphogenesis in camera type eyeGO:0060042790.065
tube morphogenesisGO:00352393490.063
ribonucleoside monophosphate catabolic processGO:000915840.063
cellular protein catabolic processGO:004425740.061
nuclear migrationGO:000709730.061
sensory organ morphogenesisGO:00905962000.060
neuron projection morphogenesisGO:00488121610.059
cellular protein metabolic processGO:00442671290.058
Human Mouse Fly
microtubule based processGO:0007017600.056
Human Mouse Fly
negative regulation of cellular processGO:00485232830.053
regulation of microtubule cytoskeleton organizationGO:007050730.053
Human Fly
central nervous system developmentGO:00074173870.053
oocyte maturationGO:000155640.052
regulation of bindingGO:005109830.052
regulation of cellular biosynthetic processGO:00313262450.051
regulation of intracellular protein transportGO:003315730.051
regulation of protein import into nucleusGO:004230620.051
signal transductionGO:00071654550.051
regulation of transcription from rna polymerase ii promoterGO:00063571140.051
immune system processGO:00023762410.050
regulation of multicellular organism growthGO:004001440.050
regulation of apoptotic processGO:0042981980.049
organic substance biosynthetic processGO:19015762890.049
positive regulation of cell cycleGO:004578730.049
Human
positive regulation of biological processGO:00485182530.048
Human Fly
cell cycle g2 m phase transitionGO:004483940.048
positive regulation of cellular component biogenesisGO:004408930.047
Human
single organism localizationGO:19025782250.045
regulation of response to stimulusGO:00485832690.045
nuclear importGO:005117030.044
response to drugGO:004249330.043
programmed cell deathGO:00125011190.043
single organism transportGO:00447652060.042
regulation of programmed cell deathGO:00430671010.042
proteasomal protein catabolic processGO:001049820.042
developmental growthGO:00485891660.041
cellular component movementGO:00069283350.041
embryonic organ developmentGO:00485683810.041
Mouse
vasculature developmentGO:00019442780.041
regulation of protein catabolic processGO:004217610.041
Fly
embryonic organ morphogenesisGO:00485622740.041
regulation of protein targetingGO:190353320.040
regulation of cell deathGO:00109411030.039
phosphorus metabolic processGO:00067931090.039
Human Mouse Fly
regulation of multicellular organismal processGO:00512392770.039
histone h3 k4 methylationGO:005156820.038
hemopoiesisGO:00300971830.038
smoothened signaling pathwayGO:0007224300.038
mitotic g2 dna damage checkpointGO:000709530.037
convergent extensionGO:00600261180.037
mitotic sister chromatid segregationGO:000007060.037
regulation of nucleobase containing compound metabolic processGO:00192192500.036
cell substrate adhesionGO:003158940.036
deathGO:00162651210.036
embryo development ending in birth or egg hatchingGO:00097922710.036
Mouse
mitotic dna damage checkpointGO:004477340.036
nuclear envelope organizationGO:000699820.035
microtubule bundle formationGO:000157890.035
Fly
anterior posterior pattern specificationGO:00099521520.035
peptidyl serine modificationGO:001820920.035
cell motilityGO:00488702440.035
nucleocytoplasmic transportGO:000691340.035
single organism nuclear importGO:190259330.034
peptidyl serine phosphorylationGO:001810510.034
organonitrogen compound metabolic processGO:1901564740.034
microtubule cytoskeleton organization involved in mitosisGO:190285010.034
centrosome cycleGO:000709810.034
Human Mouse Fly
modification dependent protein catabolic processGO:001994130.033
protein importGO:001703830.033
homologous chromosome segregationGO:004514310.033
positive regulation of rna biosynthetic processGO:1902680570.032
positive regulation of metabolic processGO:00098931080.032
Fly
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.032
reciprocal dna recombinationGO:003582510.032
male meiosisGO:000714020.032
Fly
regionalizationGO:00030022740.032
regulation of organelle assemblyGO:190211540.032
Human Fly
regulation of developmental processGO:00507932470.032
protein targeting to nucleusGO:004474430.032
regulation of chromosome segregationGO:005198310.031
intracellular signal transductionGO:0035556850.031
positive regulation of dna metabolic processGO:005105410.031
female meiotic divisionGO:000714320.031
cilium assemblyGO:0042384580.030
Fly
regulation of cytoplasmic transportGO:190364940.030
spindle assemblyGO:005122520.030
homeostatic processGO:00425921420.030
cell deathGO:00082191210.030
proteolysis involved in cellular protein catabolic processGO:005160330.029
purine nucleotide metabolic processGO:0006163270.029
cellular response to chemical stimulusGO:00708871570.029
eye photoreceptor cell developmentGO:0042462300.029
positive regulation of catabolic processGO:000989640.029
Fly
positive regulation of gene expressionGO:0010628710.029
ubiquitin dependent protein catabolic processGO:000651130.028
mitotic cell cycleGO:0000278640.028
Fly
apoptotic processGO:00069151160.028
cellular component biogenesisGO:00440851780.028
Human Mouse Fly
regulation of signalingGO:00230512350.028
positive regulation of macromolecule biosynthetic processGO:0010557590.028
cellular localizationGO:0051641970.027
negative regulation of catabolic processGO:000989530.027
regulation of cellular macromolecule biosynthetic processGO:20001122220.027
regulation of cell maturationGO:190342910.027
g2 m transition of mitotic cell cycleGO:000008640.027
response to chemicalGO:00422213200.027
positive regulation of macromolecule metabolic processGO:0010604930.027
Fly
regulation of protein localization to nucleusGO:190018020.027
specification of symmetryGO:00097992040.026
phosphorylationGO:0016310690.026
Human Mouse Fly
immune system developmentGO:00025201910.026
head developmentGO:00603223030.025
negative regulation of apoptotic processGO:0043066550.025
macromolecular complex assemblyGO:0065003350.025
negative regulation of cellular catabolic processGO:003133030.025
protein import into nucleusGO:000660630.024
positive regulation of nucleobase containing compound metabolic processGO:0045935690.024
dna metabolic processGO:0006259270.023
spindle assembly involved in meiosisGO:009030610.023
cellular response to radiationGO:007147840.023
cellular component assemblyGO:00226071700.023
Human Mouse Fly
microtubule depolymerizationGO:000701910.023
heart contractionGO:0060047710.023
negative regulation of nuclear divisionGO:005178430.023
cellular response to biotic stimulusGO:007121630.023
lipid storageGO:001991510.023
g2 dna damage checkpointGO:003157230.022
protein polymerizationGO:005125840.022
microtubule cytoskeleton organizationGO:0000226330.022
Human Mouse Fly
protein localization to nucleusGO:003450430.022
regulation of histone h3 k9 methylationGO:005157020.022
positive regulation of cellular biosynthetic processGO:0031328680.022
digestive tract developmentGO:00485652650.022
cell morphogenesis involved in neuron differentiationGO:00486671630.022
cilium organizationGO:0044782710.021
Fly
protein metabolic processGO:00195381830.021
Human Mouse Fly
inner ear receptor cell fate commitmentGO:006012040.021
stem cell maintenanceGO:001982740.021
negative regulation of metabolic processGO:0009892860.021
gastrulationGO:00073692080.021
carbohydrate derivative metabolic processGO:1901135610.021
positive regulation of transcription dna templatedGO:0045893570.021
negative regulation of cytoplasmic transportGO:190365020.020
heart morphogenesisGO:00030071560.020
mitotic dna integrity checkpointGO:004477440.020
negative regulation of ras protein signal transductionGO:004658010.020
negative regulation of cell deathGO:0060548600.020
negative regulation of nucleocytoplasmic transportGO:004682320.020
modification dependent macromolecule catabolic processGO:004363230.020
membrane organizationGO:0061024210.020
double strand break repairGO:000630230.020
regulation of cellular component organizationGO:0051128860.020
Human Fly
digestive system developmentGO:00551232890.019
regulation of protein bindingGO:004339330.019
fertilizationGO:000956630.019
embryonic heart tube morphogenesisGO:00031431080.019
dorsal ventral pattern formationGO:00099531250.019
regulation of stem cell proliferationGO:007209120.019
establishment of organelle localizationGO:0051656450.019
production of molecular mediator of immune responseGO:000244020.019
cell surface receptor signaling pathwayGO:00071663250.018
regulation of cell communicationGO:00106462320.018
ribonucleoside metabolic processGO:0009119110.018
positive regulation of cellular catabolic processGO:003133130.018
eye morphogenesisGO:00485921440.018
regulation of gene expression epigeneticGO:0040029110.018
taxisGO:00423301090.018
determination of heart left right asymmetryGO:00613711170.018
reciprocal meiotic recombinationGO:000713110.018
blood circulationGO:0008015870.018
small molecule metabolic processGO:0044281770.017
response to alkaloidGO:004327920.017
positive regulation of rna metabolic processGO:0051254590.017
cleavage furrow formationGO:003608920.017
nucleoside phosphate metabolic processGO:0006753280.017
regulation of organ growthGO:004662030.017
negative regulation of small gtpase mediated signal transductionGO:005105810.017
positive regulation of transportGO:005105020.017
negative regulation of signal transductionGO:0009968940.017
negative regulation of programmed cell deathGO:0043069580.016
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.016
lateral inhibitionGO:004633110.016
regulation of meiotic cell cycleGO:005144510.016
protein complex localizationGO:003150310.016
positive regulation of nucleic acid templated transcriptionGO:1903508570.016
polarized epithelial cell differentiationGO:003085940.016
determination of left right symmetryGO:00073681790.016
angiogenesisGO:00015251580.016
negative regulation of macromolecule metabolic processGO:0010605760.016
negative regulation of gene expressionGO:0010629650.016
oxoacid metabolic processGO:0043436310.016
system processGO:00030081850.016
organelle assemblyGO:00709251100.015
Human Mouse Fly
muscle structure developmentGO:00610611960.015
positive regulation of purine nucleotide catabolic processGO:003312310.015
protein complex subunit organizationGO:0071822460.015
Fly
chromatin modificationGO:0016568210.015
ribose phosphate metabolic processGO:0019693270.015
proteolysisGO:0006508380.015
axon guidanceGO:0007411860.015
single organism membrane organizationGO:0044802200.015
negative regulation of nucleic acid templated transcriptionGO:1903507450.015
axon developmentGO:00615641660.015
single fertilizationGO:000733830.015
camera type eye morphogenesisGO:00485931080.014
mitotic g2 m transition checkpointGO:004481830.014
nucleotide metabolic processGO:0009117280.014
neuroblast proliferationGO:000740520.014
posttranscriptional regulation of gene expressionGO:0010608140.014
Fly
blood vessel morphogenesisGO:00485142160.014
protein localization to microtubule cytoskeletonGO:007269810.014
sensory organ developmentGO:00074233930.014
cellular component disassemblyGO:002241110.014
response to endogenous stimulusGO:0009719830.014
neural retina developmentGO:0003407490.014
negative regulation of response to stimulusGO:00485851040.014
heart loopingGO:0001947940.014
negative regulation of protein complex assemblyGO:003133310.014
cell cycleGO:0007049930.014
Human Mouse Fly
agingGO:000756820.014
amine metabolic processGO:000930820.014
blood vessel developmentGO:00015682460.014
positive regulation of cell divisionGO:005178120.014
cellular response to organic substanceGO:00713101050.014
photoreceptor cell developmentGO:0042461400.014
stem cell proliferationGO:007208940.014
protein homooligomerizationGO:005126030.013
phagocytosisGO:000690930.013
regulation of stem cell differentiationGO:200073640.013
regulation of signal transductionGO:00099662250.013
synaptic growth at neuromuscular junctionGO:005112420.013
erythrocyte developmentGO:0048821240.013
cytokinesisGO:000091030.013
positive regulation of reproductive processGO:200024320.013
striated muscle cell developmentGO:00550021080.013
ventral spinal cord interneuron fate commitmentGO:006057930.013
specification of axis polarityGO:006500140.013
negative regulation of protein localization to nucleusGO:190018120.013
eye developmentGO:00016542770.013
dna templated transcription initiationGO:000635210.013
developmental maturationGO:0021700340.013
mitotic cell cycle processGO:1903047480.013
Fly
regulation of proteolysisGO:0030162240.012
circulatory system processGO:0003013870.012
mitotic nuclear divisionGO:0007067180.012
protein alkylationGO:0008213130.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
post embryonic organ developmentGO:004856940.012
regulation of cell developmentGO:00602841000.012
photoreceptor cell fate commitmentGO:004655210.012
eye photoreceptor cell differentiationGO:0001754450.012
negative regulation of chromosome organizationGO:200125110.012
microtubule polymerization or depolymerizationGO:003110930.012
dna biosynthetic processGO:007189730.012
cell substrate junction assemblyGO:000704420.012
purine ribonucleotide metabolic processGO:0009150270.012
positive regulation of chromosome organizationGO:200125210.012
positive regulation of response to stimulusGO:0048584800.012
negative regulation of nucleobase containing compound metabolic processGO:0045934590.012
carboxylic acid metabolic processGO:0019752220.012
response to stressGO:00069502630.012
regulation of cellular ketone metabolic processGO:001056570.011
myeloid cell differentiationGO:0030099860.011
single organism cellular localizationGO:1902580460.011
cellular amino acid metabolic processGO:000652070.011
negative regulation of intracellular protein transportGO:009031730.011
brain developmentGO:00074202930.011
regulation of heart growthGO:006042020.011
regulation of cell cycle g2 m phase transitionGO:190274940.011
regulation of reactive oxygen species metabolic processGO:200037720.011
macromolecule modificationGO:00434121110.011
Human Mouse Fly
negative regulation of cytokine productionGO:000181810.011
negative regulation of developmental processGO:0051093650.011
spermatid developmentGO:000728620.011
Fly
negative regulation of intracellular transportGO:003238730.011
muscle organ developmentGO:00075171010.011
regulation of nucleocytoplasmic transportGO:004682220.011
protein maturationGO:0051604120.011
female sex differentiationGO:004666040.011
regulation of histone methylationGO:003106030.011
somatic cell dna recombinationGO:001644410.011
secondary metabolic processGO:001974830.011
positive regulation of cytoskeleton organizationGO:005149530.011
Human
cellular component assembly involved in morphogenesisGO:00109271070.011
Fly
regulation of cellular amino acid metabolic processGO:000652100.011
regulation of mesenchymal cell proliferationGO:001046410.010
negative regulation of transcription dna templatedGO:0045892450.010
pronuclear migrationGO:003504610.010
positive regulation of protein complex assemblyGO:003133420.010
nuclear divisionGO:0000280230.010
Fly
interspecies interaction between organismsGO:004441940.010
negative regulation of protein transportGO:005122430.010
dna methylation on cytosineGO:003277630.010
translational initiationGO:000641330.010
myeloid cell developmentGO:0061515320.010
peptidyl threonine phosphorylationGO:001810710.010
exocrine pancreas developmentGO:0031017280.010
positive regulation of cell deathGO:0010942290.010

plk4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.034
organ system cancerDOID:005068600.034
cancerDOID:16200.034
nervous system diseaseDOID:86300.027
disease of anatomical entityDOID:700.027
disease of metabolismDOID:001466700.024
gastrointestinal system cancerDOID:311900.012
intestinal cancerDOID:1015500.012
large intestine cancerDOID:567200.012
eye and adnexa diseaseDOID:149200.011
sensory system diseaseDOID:005015500.011