Danio rerio

0 known processes

hmgcl

3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)

(Aliases: MGC56248,zgc:56248)

hmgcl biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
cellular nitrogen compound biosynthetic processGO:00442712180.083
mitochondrion organizationGO:000700540.079
proteolysis involved in cellular protein catabolic processGO:005160330.060
cellular protein catabolic processGO:004425740.059
cellular macromolecule metabolic processGO:00442603910.055
larval developmentGO:000216420.053
single organism organelle organizationGO:19025891990.051
cellular biosynthetic processGO:00442492860.045
protein localization to plasma membraneGO:007265910.045
agingGO:000756820.039
response to drugGO:004249330.038
organic substance biosynthetic processGO:19015762890.038
regulation of protein transportGO:005122330.035
cellular nitrogen compound metabolic processGO:00346412900.035
macromolecule biosynthetic processGO:00090592270.034
biosynthetic processGO:00090582940.033
regulation of establishment of protein localizationGO:007020140.033
maintenance of locationGO:005123540.033
membrane fusionGO:006102520.032
organelle fusionGO:004828430.032
ubiquitin dependent protein catabolic processGO:000651130.031
heterocycle metabolic processGO:00464832900.031
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.031
eye developmentGO:00016542770.029
homeostatic processGO:00425921420.029
organelle organizationGO:00069962270.029
nucleobase containing compound biosynthetic processGO:00346542050.029
immune system processGO:00023762410.029
rna metabolic processGO:00160702190.028
compound eye developmentGO:004874920.027
carboxylic acid metabolic processGO:0019752220.026
cellular amino acid metabolic processGO:000652070.026
protein importGO:001703830.026
nitrogen compound metabolic processGO:00068073190.026
proteasomal protein catabolic processGO:001049820.025
stem cell maintenanceGO:001982740.025
protein polyubiquitinationGO:000020940.024
lipid storageGO:001991510.024
regulation of protein ubiquitinationGO:003139630.024
exocytosisGO:000688710.023
negative regulation of protein phosphorylationGO:000193340.023
immune system developmentGO:00025201910.023
regulation of multicellular organism growthGO:004001440.023
nucleic acid metabolic processGO:00903042440.023
cellular component biogenesisGO:00440851780.023
response to stressGO:00069502630.022
positive regulation of cellular catabolic processGO:003133130.022
heterocycle biosynthetic processGO:00181302150.022
mitochondrial transportGO:000683920.022
myeloid cell differentiationGO:0030099860.022
cellular modified amino acid metabolic processGO:000657530.022
hemopoiesisGO:00300971830.021
oxoacid metabolic processGO:0043436310.021
organelle assemblyGO:00709251100.021
cellular macromolecule biosynthetic processGO:00346452240.021
positive regulation of catabolic processGO:000989640.021
modification dependent macromolecule catabolic processGO:004363230.021
nucleocytoplasmic transportGO:000691340.021
regulation of protein catabolic processGO:004217610.021
endosomal transportGO:001619720.021
guanosine containing compound catabolic processGO:190106920.021
central nervous system developmentGO:00074173870.020
regulation of biological qualityGO:00650082630.020
small molecule metabolic processGO:0044281770.020
single organism membrane fusionGO:004480120.020
positive regulation of transportGO:005105020.020
gene expressionGO:00104672520.020
hematopoietic or lymphoid organ developmentGO:00485341910.020
myeloid cell homeostasisGO:0002262560.020
sensory organ developmentGO:00074233930.020
rna localizationGO:000640340.019
cellular ketone metabolic processGO:0042180110.019
cytoskeleton organizationGO:0007010960.019
erythrocyte differentiationGO:0030218540.019
multicellular organism growthGO:003526440.019
response to chemicalGO:00422213200.019
regulation of intracellular protein transportGO:003315730.019
heart developmentGO:00075073130.019
regulation of protein localization to plasma membraneGO:190307610.018
nucleobase containing compound metabolic processGO:00061392740.018
adherens junction organizationGO:003433240.018
modification dependent protein catabolic processGO:001994130.018
regulation of oocyte developmentGO:006028130.018
response to abiotic stimulusGO:00096281220.018
gtp metabolic processGO:004603940.018
single organism metabolic processGO:00447102170.018
nuclear transportGO:005116940.018
transmembrane transportGO:00550851200.018
cellular component assembly involved in morphogenesisGO:00109271070.017
muscle structure developmentGO:00610611960.017
cellular component assemblyGO:00226071700.017
guanosine containing compound metabolic processGO:190106840.017
homeostasis of number of cellsGO:0048872620.017
amine metabolic processGO:000930820.017
synaptic growth at neuromuscular junctionGO:005112420.017
regulation of synapse organizationGO:005080730.017
cellular response to external stimulusGO:007149620.017
pole plasm assemblyGO:000731540.016
organonitrogen compound metabolic processGO:1901564740.016
cellular response to starvationGO:000926710.016
regulation of purine nucleotide catabolic processGO:003312120.016
cellular component movementGO:00069283350.016
gtp catabolic processGO:000618420.016
regulation of gtpase activityGO:004308720.016
rna biosynthetic processGO:00327741810.016
regulation of cellular amino acid metabolic processGO:000652100.016
establishment of protein localization to organelleGO:007259440.016
embryonic organ morphogenesisGO:00485622740.016
striated muscle cell differentiationGO:00511461290.016
regulation of cellular ketone metabolic processGO:001056570.016
purine ribonucleoside monophosphate catabolic processGO:000916940.016
aromatic compound biosynthetic processGO:00194382170.015
actin cytoskeleton organizationGO:0030036630.015
regulation of cytoplasmic transportGO:190364940.015
embryonic organ developmentGO:00485683810.015
regulation of cellular amine metabolic processGO:003323800.015
alpha amino acid metabolic processGO:190160530.015
establishment of protein localization to plasma membraneGO:009000210.015
nucleic acid templated transcriptionGO:00976591810.015
response to glucocorticoidGO:005138410.015
regulation of nucleotide catabolic processGO:003081120.015
regulation of tube sizeGO:003515020.015
organic acid metabolic processGO:0006082310.015
response to nutrientGO:000758430.015
single organism localizationGO:19025782250.014
cellular response to nutrient levelsGO:003166920.014
regulation of biosynthetic processGO:00098892500.014
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.014
response to corticosteroidGO:003196010.014
signal transductionGO:00071654550.014
regulation of mrna processingGO:005068430.014
head developmentGO:00603223030.014
hepaticobiliary system developmentGO:0061008980.014
establishment of localizationGO:00512342440.014
macromolecule modificationGO:00434121110.013
regulation of synapse assemblyGO:005196330.013
regulation of nucleobase containing compound metabolic processGO:00192192500.013
cell substrate adhesionGO:003158940.013
positive regulation of cellular amine metabolic processGO:003324000.013
single organism transportGO:00447652060.013
regulation of protein complex assemblyGO:004325430.013
regulation of localizationGO:00328791040.013
autophagyGO:000691440.013
negative regulation of kinase activityGO:003367340.013
regulation of gene expressionGO:00104682650.013
regulation of reproductive processGO:200024140.013
regulation of macromolecule metabolic processGO:00602553170.013
regulation of rna biosynthetic processGO:20011412130.013
i kappab kinase nf kappab signalingGO:000724940.013
regulation of cell activationGO:005086510.013
transcription dna templatedGO:00063511810.012
stem cell divisionGO:001714510.012
meiosis iGO:000712710.012
response to external stimulusGO:00096052640.012
regulation of developmental processGO:00507932470.012
protein metabolic processGO:00195381830.012
cellular aromatic compound metabolic processGO:00067252950.012
regulation of primary metabolic processGO:00800903110.012
regulation of metabolic processGO:00192223590.012
negative regulation of map kinase activityGO:004340720.012
regulation of rna metabolic processGO:00512522240.012
regulation of hormone secretionGO:004688320.012
protein targeting to nucleusGO:004474430.012
positive regulation of secretion by cellGO:190353210.012
response to monosaccharideGO:003428430.012
embryo development ending in birth or egg hatchingGO:00097922710.012
regulation of protein import into nucleusGO:004230620.012
regulation of i kappab kinase nf kappab signalingGO:004312240.012
catechol containing compound metabolic processGO:000971220.011
cytokinesisGO:000091030.011
sensory organ morphogenesisGO:00905962000.011
regulation of bindingGO:005109830.011
centrosome cycleGO:000709810.011
protein k48 linked ubiquitinationGO:007093610.011
adult behaviorGO:003053420.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
muscle cell differentiationGO:00426921390.011
brain developmentGO:00074202930.011
positive regulation of cellular component biogenesisGO:004408930.011
skeletal system morphogenesisGO:00487051020.011
regulation of cellular biosynthetic processGO:00313262450.011
protein homooligomerizationGO:005126030.011
locomotionGO:00400113130.011
organic cyclic compound metabolic processGO:19013603010.011
energy reserve metabolic processGO:000611220.011
meiotic cell cycle processGO:190304630.011
spindle assemblyGO:005122520.011
transcription from rna polymerase ii promoterGO:0006366800.011
cellular component disassemblyGO:002241110.011
female sex differentiationGO:004666040.011
regulation of protein modification by small protein conjugation or removalGO:190332030.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
cellular amine metabolic processGO:004410620.011
regulation of nucleoside metabolic processGO:000911820.011
regulation of cellular metabolic processGO:00313233200.011
cytoskeleton dependent cytokinesisGO:006164030.011
regulation of carbohydrate metabolic processGO:000610940.011
regulation of transcription dna templatedGO:00063552130.011
negative regulation of protein serine threonine kinase activityGO:007190120.011
response to uvGO:000941130.011
positive regulation of cell cycleGO:004578730.011
muscle cell developmentGO:00550011150.011
regulation of blood pressureGO:000821710.011
camera type eye developmentGO:00430102220.011
muscle tissue developmentGO:00605371100.011
germ line stem cell maintenanceGO:003071820.010
peptide transportGO:001583310.010
golgi vesicle transportGO:004819330.010
negative regulation of synapse assemblyGO:005196420.010
cell morphogenesisGO:00009022890.010
single organism nuclear importGO:190259330.010
negative regulation of multi organism processGO:004390130.010
glial cell migrationGO:000834730.010
carbohydrate biosynthetic processGO:001605110.010
ribonucleoside monophosphate catabolic processGO:000915840.010
regulation of organ growthGO:004662030.010
cell surface receptor signaling pathwayGO:00071663250.010
nucleobase containing compound transportGO:001593120.010
morphogenesis of an epitheliumGO:00020093330.010
germ line stem cell divisionGO:004207810.010
positive regulation of nucleotide catabolic processGO:003081310.010
nuclear importGO:005117030.010
regulation of protein localization to nucleusGO:190018020.010
positive regulation of cytokine productionGO:000181920.010
ion transportGO:00068111140.010
female gonad developmentGO:000858540.010
renal tubule morphogenesisGO:006133310.010
regulation of gtp catabolic processGO:003312420.010

hmgcl disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.025
inherited metabolic disorderDOID:65500.025
mitochondrial metabolism diseaseDOID:70000.018
disease of cellular proliferationDOID:1456600.015
organ system cancerDOID:005068600.014
cancerDOID:16200.014
disease of anatomical entityDOID:700.014