IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

atp5h

ATP synthase, H+ transporting, mitochondrial F0 complex, subunit d

(Aliases: MGC73071,zgc:73071)

Entrez: 393675
ZFIN: ZDB-GENE-040426-1658
Ensembl: ENSDARG00000025635
UniProtKB: Q6PC77

Process Predictions
Disease Predictions

atp5h biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
larval development	GO:0002164	2	0.639	Worm
aging	GO:0007568	2	0.317	Worm
oxidation reduction process	GO:0055114	41	0.169
nitrogen compound metabolic process	GO:0006807	319	0.161	Human
single organism metabolic process	GO:0044710	217	0.160	Human
small molecule metabolic process	GO:0044281	77	0.129	Human
hydrogen peroxide metabolic process	GO:0042743	2	0.114
homeostatic process	GO:0042592	142	0.106
mitochondrion organization	GO:0007005	4	0.095
embryo development ending in birth or egg hatching	GO:0009792	271	0.095	Worm
multicellular organism growth	GO:0035264	4	0.088
reproduction	GO:0000003	40	0.084	Worm
regulation of gene expression	GO:0010468	265	0.084
cellular macromolecule metabolic process	GO:0044260	391	0.079
negative regulation of biological process	GO:0048519	304	0.078
maintenance of location	GO:0051235	4	0.078
negative regulation of cellular process	GO:0048523	283	0.076
positive regulation of biological process	GO:0048518	253	0.072
response to stress	GO:0006950	263	0.071
regulation of metabolic process	GO:0019222	359	0.065
regulation of multicellular organismal process	GO:0051239	277	0.064
regulation of macromolecule metabolic process	GO:0060255	317	0.062
amine metabolic process	GO:0009308	2	0.062
regulation of developmental process	GO:0050793	247	0.059
hemopoiesis	GO:0030097	183	0.056
central nervous system development	GO:0007417	387	0.055
positive regulation of cellular process	GO:0048522	201	0.055
heart development	GO:0007507	313	0.053
immune system process	GO:0002376	241	0.053
rna biosynthetic process	GO:0032774	181	0.048
organic substance biosynthetic process	GO:1901576	289	0.048
regulation of primary metabolic process	GO:0080090	311	0.048
organic acid metabolic process	GO:0006082	31	0.046
biosynthetic process	GO:0009058	294	0.046
signal transduction	GO:0007165	455	0.045
negative regulation of macromolecule metabolic process	GO:0010605	76	0.045
cellular amine metabolic process	GO:0044106	2	0.045
organic cyclic compound metabolic process	GO:1901360	301	0.044	Human
locomotion	GO:0040011	313	0.041
response to chemical	GO:0042221	320	0.041
protein acetylation	GO:0006473	2	0.041
regulation of cellular metabolic process	GO:0031323	320	0.040
regulation of multicellular organism growth	GO:0040014	4	0.040
blood vessel development	GO:0001568	246	0.037
brain development	GO:0007420	293	0.037
programmed cell death	GO:0012501	119	0.036
organonitrogen compound metabolic process	GO:1901564	74	0.036	Human
regulation of cell differentiation	GO:0045595	142	0.035
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.034
head development	GO:0060322	303	0.034
gene expression	GO:0010467	252	0.034
carboxylic acid metabolic process	GO:0019752	22	0.034
regulation of cell death	GO:0010941	103	0.033
determination of heart left right asymmetry	GO:0061371	117	0.033
negative regulation of metabolic process	GO:0009892	86	0.033
multi organism process	GO:0051704	134	0.033
cellular response to chemical stimulus	GO:0070887	157	0.032
nuclear transport	GO:0051169	4	0.032
regulation of macromolecule biosynthetic process	GO:0010556	225	0.032
centrosome cycle	GO:0007098	1	0.032
transmembrane transport	GO:0055085	120	0.031
response to abiotic stimulus	GO:0009628	122	0.031
regulation of cellular ketone metabolic process	GO:0010565	7	0.031
cell proliferation	GO:0008283	80	0.031
post embryonic development	GO:0009791	7	0.031	Worm
heterocycle biosynthetic process	GO:0018130	215	0.030
regulation of biosynthetic process	GO:0009889	250	0.030
cellular aromatic compound metabolic process	GO:0006725	295	0.030	Human
oxoacid metabolic process	GO:0043436	31	0.030
actin polymerization or depolymerization	GO:0008154	2	0.030
transcription dna templated	GO:0006351	181	0.029
cellular nitrogen compound metabolic process	GO:0034641	290	0.028	Human
negative regulation of gene expression	GO:0010629	65	0.027
regulation of biological quality	GO:0065008	263	0.027
cellular protein metabolic process	GO:0044267	129	0.026
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.026
rna metabolic process	GO:0016070	219	0.026
regulation of cellular amine metabolic process	GO:0033238	0	0.025
response to organic substance	GO:0010033	153	0.025
single organism localization	GO:1902578	225	0.025
apoptotic process	GO:0006915	116	0.025
homeostasis of number of cells	GO:0048872	62	0.024
regulation of programmed cell death	GO:0043067	101	0.024
negative regulation of rna biosynthetic process	GO:1902679	45	0.024
negative regulation of transcription dna templated	GO:0045892	45	0.023
response to other organism	GO:0051707	97	0.023
regulation of nucleocytoplasmic transport	GO:0046822	2	0.023
embryonic organ development	GO:0048568	381	0.023
nucleobase containing compound metabolic process	GO:0006139	274	0.021	Human
aromatic compound biosynthetic process	GO:0019438	217	0.021
negative regulation of cellular metabolic process	GO:0031324	77	0.021
cellular ketone metabolic process	GO:0042180	11	0.020
determination of bilateral symmetry	GO:0009855	204	0.020
collagen biosynthetic process	GO:0032964	2	0.020
embryonic heart tube morphogenesis	GO:0003143	108	0.020
protein modification process	GO:0036211	100	0.020
negative regulation of programmed cell death	GO:0043069	58	0.019
positive regulation of multicellular organismal process	GO:0051240	52	0.019
nucleic acid metabolic process	GO:0090304	244	0.019
regulation of inflammatory response	GO:0050727	2	0.019
negative regulation of kinase activity	GO:0033673	4	0.018
nucleotide metabolic process	GO:0009117	28	0.018	Human
regulation of nitrogen compound metabolic process	GO:0051171	251	0.018
transcription from rna polymerase ii promoter	GO:0006366	80	0.018
regulation of signal transduction	GO:0009966	225	0.018
regulation of catalytic activity	GO:0050790	55	0.018
regulation of protein metabolic process	GO:0051246	56	0.018
regulation of cellular biosynthetic process	GO:0031326	245	0.018
embryonic organ morphogenesis	GO:0048562	274	0.018
negative regulation of cytoplasmic transport	GO:1903650	2	0.018
embryonic heart tube development	GO:0035050	133	0.018
proton transport	GO:0015992	7	0.018
stem cell proliferation	GO:0072089	4	0.017
regulation of neural precursor cell proliferation	GO:2000177	3	0.017
angiogenesis	GO:0001525	158	0.017
regulation of stem cell proliferation	GO:0072091	2	0.017
fatty acid oxidation	GO:0019395	1	0.017
negative regulation of rna metabolic process	GO:0051253	48	0.017
establishment of localization	GO:0051234	244	0.017
regulation of apoptotic process	GO:0042981	98	0.017
lipid storage	GO:0019915	1	0.017
growth	GO:0040007	174	0.017
regulation of cell proliferation	GO:0042127	37	0.016
positive regulation of developmental process	GO:0051094	50	0.016
negative regulation of cell death	GO:0060548	60	0.016
response to oxygen containing compound	GO:1901700	55	0.016
tube morphogenesis	GO:0035239	349	0.016
negative regulation of developmental process	GO:0051093	65	0.016
hydrogen transport	GO:0006818	7	0.016
cell death	GO:0008219	121	0.015
cell migration	GO:0016477	237	0.015
regulation of blood pressure	GO:0008217	1	0.015
negative regulation of cellular biosynthetic process	GO:0031327	55	0.015
behavior	GO:0007610	74	0.015
respiratory electron transport chain	GO:0022904	2	0.015
directional locomotion	GO:0033058	1	0.015
immune system development	GO:0002520	191	0.015
atp catabolic process	GO:0006200	4	0.015	Human
cell death in response to oxidative stress	GO:0036473	2	0.015
oxidative phosphorylation	GO:0006119	1	0.015
response to external biotic stimulus	GO:0043207	97	0.015
organic cyclic compound biosynthetic process	GO:1901362	223	0.014
regulation of cytoplasmic transport	GO:1903649	4	0.014
cellular localization	GO:0051641	97	0.014
negative regulation of apoptotic process	GO:0043066	55	0.014
regulation of transcription dna templated	GO:0006355	213	0.014
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.014
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.014
protein metabolic process	GO:0019538	183	0.014
organelle organization	GO:0006996	227	0.014
morphogenesis of an epithelium	GO:0002009	333	0.014
ion transport	GO:0006811	114	0.014
regulation of rho protein signal transduction	GO:0035023	2	0.014
regulation of response to oxidative stress	GO:1902882	2	0.014
positive regulation of immune effector process	GO:0002699	3	0.014
regulation of cytokine production	GO:0001817	3	0.013
response to hydrogen peroxide	GO:0042542	3	0.013
nucleobase containing compound biosynthetic process	GO:0034654	205	0.013
death	GO:0016265	121	0.013
nucleic acid templated transcription	GO:0097659	181	0.013
regulation of retina development in camera type eye	GO:1902866	2	0.013
cellular component movement	GO:0006928	335	0.013
intracellular signal transduction	GO:0035556	85	0.013
single organism transport	GO:0044765	206	0.013
cellular macromolecule biosynthetic process	GO:0034645	224	0.013
developmental growth	GO:0048589	166	0.013
response to biotic stimulus	GO:0009607	97	0.012
positive regulation of cellular amine metabolic process	GO:0033240	0	0.012
body morphogenesis	GO:0010171	16	0.012
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.012
pyruvate metabolic process	GO:0006090	1	0.012
determination of left right symmetry	GO:0007368	179	0.012
multicellular organismal metabolic process	GO:0044236	2	0.012
heart morphogenesis	GO:0003007	156	0.012
neuroblast proliferation	GO:0007405	2	0.012
photoreceptor cell fate commitment	GO:0046552	1	0.011
muscle cell development	GO:0055001	115	0.011
heart looping	GO:0001947	94	0.011
multicellular organismal reproductive process	GO:0048609	35	0.011
reproductive process	GO:0022414	40	0.011	Worm
regulation of intracellular protein transport	GO:0033157	3	0.011
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	2	0.011
erythrocyte homeostasis	GO:0034101	55	0.011
macromolecule modification	GO:0043412	111	0.011
regulation of rna metabolic process	GO:0051252	224	0.011
regulation of nucleoside metabolic process	GO:0009118	2	0.011
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.010
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.010
regulation of membrane potential	GO:0042391	23	0.010
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.010
mitochondrial transport	GO:0006839	2	0.010
specification of symmetry	GO:0009799	204	0.010
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.010
phosphorus metabolic process	GO:0006793	109	0.010	Human
leukocyte proliferation	GO:0070661	1	0.010
reactive oxygen species metabolic process	GO:0072593	6	0.010
cell surface receptor signaling pathway	GO:0007166	325	0.010
hydrogen ion transmembrane transport	GO:1902600	6	0.010

atp5h disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
inherited metabolic disorder	DOID:655	0.141
mitochondrial metabolism disease	DOID:700	0.141
disease of metabolism	DOID:0014667	0.141
leigh disease	DOID:3652	0.042
disease of anatomical entity	DOID:7	0.015
connective tissue disease	DOID:65	0.012
musculoskeletal system disease	DOID:17	0.012

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