IMP: Integrative Multi-species Prediction

Danio rerio

81 known processes

pea3

ETS-domain transcription factor pea3

(Aliases: etv4)

Process Predictions
Disease Predictions

pea3 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular aromatic compound metabolic process	GO:0006725	295	0.989
response to stress	GO:0006950	263	0.979
immune system process	GO:0002376	241	0.962	Zebrafish
cilium morphogenesis	GO:0060271	85	0.943
eye development	GO:0001654	277	0.901
pronephros development	GO:0048793	69	0.900
regulation of biosynthetic process	GO:0009889	250	0.892
rna metabolic process	GO:0016070	219	0.890
cell growth	GO:0016049	57	0.887
camera type eye morphogenesis	GO:0048593	108	0.876
regulation of primary metabolic process	GO:0080090	311	0.874
negative regulation of biological process	GO:0048519	304	0.859	Mouse
regulation of response to stimulus	GO:0048583	269	0.855
positive regulation of biological process	GO:0048518	253	0.854
angiogenesis	GO:0001525	158	0.850	Zebrafish
organic cyclic compound metabolic process	GO:1901360	301	0.809
hindbrain development	GO:0030902	91	0.799
sensory organ development	GO:0007423	393	0.792
brain development	GO:0007420	293	0.789	Zebrafish
regulation of metabolic process	GO:0019222	359	0.787
regulation of cellular metabolic process	GO:0031323	320	0.784
cell morphogenesis involved in differentiation	GO:0000904	195	0.781	Mouse
negative regulation of signaling	GO:0023057	96	0.777
ameboidal type cell migration	GO:0001667	143	0.768
chordate embryonic development	GO:0043009	271	0.764
formation of primary germ layer	GO:0001704	62	0.762	Zebrafish
negative regulation of cell communication	GO:0010648	96	0.760
specification of organ identity	GO:0010092	2	0.759
kidney development	GO:0001822	92	0.722
cell surface receptor signaling pathway	GO:0007166	325	0.721
negative regulation of signal transduction	GO:0009968	94	0.707
blood vessel morphogenesis	GO:0048514	216	0.696	Zebrafish
developmental growth	GO:0048589	166	0.691
positive regulation of notch signaling pathway	GO:0045747	3	0.689
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.663
vasculature development	GO:0001944	278	0.660	Zebrafish
digestive tract morphogenesis	GO:0048546	231	0.647	Zebrafish
nitrogen compound metabolic process	GO:0006807	319	0.645
central nervous system development	GO:0007417	387	0.606	Zebrafish
camera type eye development	GO:0043010	222	0.604
mesenchymal cell differentiation	GO:0048762	87	0.600	Zebrafish
macromolecule biosynthetic process	GO:0009059	227	0.596
cell part morphogenesis	GO:0032990	246	0.595	Mouse
cellular macromolecule metabolic process	GO:0044260	391	0.591
negative regulation of cellular process	GO:0048523	283	0.591	Mouse
heart morphogenesis	GO:0003007	156	0.591	Zebrafish
compound eye development	GO:0048749	2	0.578
larval development	GO:0002164	2	0.577
head development	GO:0060322	303	0.576	Zebrafish
regulation of reproductive process	GO:2000241	4	0.575
regulation of gene expression	GO:0010468	265	0.575
anatomical structure homeostasis	GO:0060249	36	0.567
epithelial cell morphogenesis	GO:0003382	2	0.556
forebrain development	GO:0030900	96	0.555	Zebrafish
cellular nitrogen compound metabolic process	GO:0034641	290	0.552
cell cycle	GO:0007049	93	0.544	Zebrafish
immune system development	GO:0002520	191	0.538	Zebrafish
gene expression	GO:0010467	252	0.536
axon development	GO:0061564	166	0.534	Mouse
eye morphogenesis	GO:0048592	144	0.529
mesoderm development	GO:0007498	88	0.526	Zebrafish
negative regulation of response to stimulus	GO:0048585	104	0.516
sensory organ morphogenesis	GO:0090596	200	0.509
regulation of multicellular organismal process	GO:0051239	277	0.509	Mouse
response to organic substance	GO:0010033	153	0.501
generation of neurons	GO:0048699	385	0.495	Mouse
regionalization	GO:0003002	274	0.495
nucleic acid metabolic process	GO:0090304	244	0.492
axon guidance	GO:0007411	86	0.477	Mouse
radial glial cell differentiation	GO:0060019	2	0.473
hematopoietic or lymphoid organ development	GO:0048534	191	0.472	Zebrafish
neuroblast proliferation	GO:0007405	2	0.470
stem cell proliferation	GO:0072089	4	0.468
positive regulation of stem cell proliferation	GO:2000648	1	0.464
response to chemical	GO:0042221	320	0.444	Mouse
positive regulation of macromolecule metabolic process	GO:0010604	93	0.439
locomotion	GO:0040011	313	0.435	Mouse
mesodermal cell differentiation	GO:0048333	21	0.435	Zebrafish
regulation of cell differentiation	GO:0045595	142	0.434
embryonic organ morphogenesis	GO:0048562	274	0.430
segmentation	GO:0035282	97	0.429
negative regulation of wnt signaling pathway	GO:0030178	30	0.427
neuron migration	GO:0001764	22	0.415
mesenchyme development	GO:0060485	127	0.408	Zebrafish
embryonic organ development	GO:0048568	381	0.407	Zebrafish
neuron development	GO:0048666	262	0.403	Mouse
hepaticobiliary system development	GO:0061008	98	0.402
embryonic pattern specification	GO:0009880	44	0.385
neuron projection extension	GO:1990138	45	0.385
single organism metabolic process	GO:0044710	217	0.380
programmed cell death	GO:0012501	119	0.379
optic placode formation involved in camera type eye formation	GO:0046619	3	0.377
ectodermal placode development	GO:0071696	37	0.376
lens morphogenesis in camera type eye	GO:0002089	7	0.372
negative regulation of kinase activity	GO:0033673	4	0.370
neuron projection morphogenesis	GO:0048812	161	0.367	Mouse
ectodermal placode morphogenesis	GO:0071697	32	0.365
regulation of stem cell proliferation	GO:0072091	2	0.359
heterocycle metabolic process	GO:0046483	290	0.358
muscle tissue development	GO:0060537	110	0.356
cell migration	GO:0016477	237	0.356
cell morphogenesis	GO:0000902	289	0.355	Mouse
skeletal system development	GO:0001501	181	0.352
midbrain development	GO:0030901	28	0.349
regulation of cell growth	GO:0001558	29	0.343
nephron morphogenesis	GO:0072028	2	0.336
single organism organelle organization	GO:1902589	199	0.336
death	GO:0016265	121	0.333
cellular biosynthetic process	GO:0044249	286	0.333
hemopoiesis	GO:0030097	183	0.333	Zebrafish
negative regulation of catenin import into nucleus	GO:0035414	2	0.332
embryonic skeletal system development	GO:0048706	97	0.329
cell death	GO:0008219	121	0.319
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.317
regulation of nervous system development	GO:0051960	90	0.315
digestive system development	GO:0055123	289	0.314	Zebrafish
cellular protein metabolic process	GO:0044267	129	0.313
mesoderm morphogenesis	GO:0048332	51	0.310	Zebrafish
positive regulation of cellular process	GO:0048522	201	0.306
regulation of apoptotic process	GO:0042981	98	0.302
regulation of stem cell differentiation	GO:2000736	4	0.297
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.297
nephron epithelium morphogenesis	GO:0072088	1	0.296
heart looping	GO:0001947	94	0.288
regulation of signal transduction	GO:0009966	225	0.288
apoptotic process	GO:0006915	116	0.288
response to growth factor	GO:0070848	39	0.287
embryo development ending in birth or egg hatching	GO:0009792	271	0.284
positive regulation of metabolic process	GO:0009893	108	0.283
regulation of axonogenesis	GO:0050770	32	0.269
post embryonic organ development	GO:0048569	4	0.269
regulation of cellular biosynthetic process	GO:0031326	245	0.268
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.267
blood vessel development	GO:0001568	246	0.266	Zebrafish
regulation of developmental process	GO:0050793	247	0.265	Mouse
neural crest cell differentiation	GO:0014033	72	0.264
stem cell development	GO:0048864	82	0.260
reproductive process	GO:0022414	40	0.259
nephron tubule morphogenesis	GO:0072078	1	0.257
cell projection organization	GO:0030030	284	0.257	Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.257
motor neuron axon guidance	GO:0008045	23	0.257	Mouse
stem cell differentiation	GO:0048863	117	0.255	Zebrafish Mouse
negative regulation of macromolecule metabolic process	GO:0010605	76	0.249
nucleobase containing compound metabolic process	GO:0006139	274	0.247
signal transduction	GO:0007165	455	0.244
tissue homeostasis	GO:0001894	25	0.243
behavior	GO:0007610	74	0.242
stem cell maintenance	GO:0019827	4	0.241
neural tube development	GO:0021915	62	0.238
positive regulation of reproductive process	GO:2000243	2	0.237
regulation of macromolecule biosynthetic process	GO:0010556	225	0.237
growth	GO:0040007	174	0.235
aromatic compound biosynthetic process	GO:0019438	217	0.233
retinal ganglion cell axon guidance	GO:0031290	35	0.231
heart field specification	GO:0003128	1	0.230
biosynthetic process	GO:0009058	294	0.228
positive regulation of multicellular organismal process	GO:0051240	52	0.228
homeostatic process	GO:0042592	142	0.228
negative regulation of cellular metabolic process	GO:0031324	77	0.226
appendage development	GO:0048736	80	0.226
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.226	Mouse
regulation of epithelial cell proliferation	GO:0050678	3	0.225	Mouse
mesoderm formation	GO:0001707	43	0.224	Zebrafish
single organism reproductive process	GO:0044702	40	0.219
gland development	GO:0048732	143	0.219	Zebrafish Mouse
vestibular receptor cell differentiation	GO:0060114	3	0.217
regulation of intracellular protein transport	GO:0033157	3	0.215
mesenchymal cell development	GO:0014031	78	0.213
regulation of nucleic acid templated transcription	GO:1903506	213	0.213
endoderm formation	GO:0001706	29	0.212
cell motility	GO:0048870	244	0.212
neural crest cell development	GO:0014032	62	0.212
epithelial tube morphogenesis	GO:0060562	148	0.210	Mouse
notch signaling pathway	GO:0007219	35	0.204
establishment of localization	GO:0051234	244	0.204
regulation of canonical wnt signaling pathway	GO:0060828	34	0.201
heart development	GO:0007507	313	0.200	Zebrafish
ectoderm formation	GO:0001705	2	0.200
developmental process involved in reproduction	GO:0003006	27	0.200
regeneration	GO:0031099	91	0.200
negative regulation of catalytic activity	GO:0043086	21	0.200
cell fate specification	GO:0001708	68	0.199
regulation of transcription dna templated	GO:0006355	213	0.198
regulation of axon extension	GO:0030516	24	0.196
multi organism reproductive process	GO:0044703	36	0.195
neural precursor cell proliferation	GO:0061351	20	0.195
organelle organization	GO:0006996	227	0.194
cellular component movement	GO:0006928	335	0.194	Mouse
single fertilization	GO:0007338	3	0.193
patterning of blood vessels	GO:0001569	15	0.192
regulation of kinase activity	GO:0043549	15	0.190
embryonic skeletal system morphogenesis	GO:0048704	93	0.188
response to oxygen levels	GO:0070482	25	0.186
multicellular organismal homeostasis	GO:0048871	29	0.185
cardiocyte differentiation	GO:0035051	44	0.185
regulation of wnt signaling pathway	GO:0030111	53	0.184
morphogenesis of an epithelium	GO:0002009	333	0.183	Mouse
negative regulation of neutrophil migration	GO:1902623	3	0.182
protein metabolic process	GO:0019538	183	0.180
regulation of cell size	GO:0008361	29	0.180
lens development in camera type eye	GO:0002088	22	0.180
positive chemotaxis	GO:0050918	5	0.179
positive regulation of apoptotic process	GO:0043065	29	0.179
positive regulation of nervous system development	GO:0051962	25	0.177
skeletal system morphogenesis	GO:0048705	102	0.175
protein import into nucleus	GO:0006606	3	0.174
anterior posterior pattern specification	GO:0009952	152	0.173
morphogenesis of a branching epithelium	GO:0061138	16	0.171	Mouse
microtubule based process	GO:0007017	60	0.171
neuron differentiation	GO:0030182	353	0.170	Mouse
response to abiotic stimulus	GO:0009628	122	0.170
locus ceruleus development	GO:0021703	3	0.168
embryonic eye morphogenesis	GO:0048048	30	0.168
regulation of extrinsic apoptotic signaling pathway in absence of ligand	GO:2001239	1	0.167
regulation of mitotic cell cycle	GO:0007346	25	0.167	Zebrafish
response to external stimulus	GO:0009605	264	0.164	Mouse
negative regulation of multicellular organismal process	GO:0051241	69	0.164	Mouse
cellular response to chemical stimulus	GO:0070887	157	0.163
somatic stem cell maintenance	GO:0035019	1	0.163
negative regulation of canonical wnt signaling pathway	GO:0090090	21	0.163
nucleic acid templated transcription	GO:0097659	181	0.162
cell projection morphogenesis	GO:0048858	244	0.161	Mouse
negative regulation of metabolic process	GO:0009892	86	0.161
heterophilic cell cell adhesion via plasma membrane cell adhesion molecules	GO:0007157	2	0.160
odontogenesis of dentin containing tooth	GO:0042475	1	0.160
regulation of mesenchymal cell proliferation	GO:0010464	1	0.157
spinal cord radial glial cell differentiation	GO:0021531	2	0.155
negative regulation of stem cell differentiation	GO:2000737	2	0.153
regulation of anatomical structure size	GO:0090066	33	0.153
cellular response to growth factor stimulus	GO:0071363	39	0.151
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.151
regulation of ectoderm development	GO:2000383	2	0.148
axon extension	GO:0048675	45	0.148
developmental maturation	GO:0021700	34	0.146
regulation of cell death	GO:0010941	103	0.144
regulation of nitrogen compound metabolic process	GO:0051171	251	0.144
embryonic camera type eye development	GO:0031076	29	0.142
diencephalon development	GO:0021536	58	0.142	Zebrafish
regulation of positive chemotaxis	GO:0050926	4	0.142
regulation of notch signaling pathway	GO:0008593	16	0.141
positive regulation of gene expression	GO:0010628	71	0.141
adrenal gland development	GO:0030325	10	0.140	Zebrafish
negative regulation of protein phosphorylation	GO:0001933	4	0.139
digestive tract development	GO:0048565	265	0.139	Zebrafish
renal tubule morphogenesis	GO:0061333	1	0.138
regulation of cellular component organization	GO:0051128	86	0.137
nephron epithelium development	GO:0072009	16	0.136
regulation of multicellular organismal development	GO:2000026	223	0.135	Mouse
cell differentiation in spinal cord	GO:0021515	40	0.134
regulation of programmed cell death	GO:0043067	101	0.133
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.132
regulation of extent of cell growth	GO:0061387	29	0.131
positive regulation of cellular metabolic process	GO:0031325	94	0.130
forebrain cell migration	GO:0021885	1	0.130
cellular response to external stimulus	GO:0071496	2	0.130
induction of positive chemotaxis	GO:0050930	4	0.129
posterior lateral line system development	GO:0048915	46	0.129
negative regulation of biosynthetic process	GO:0009890	55	0.129
cardiac muscle tissue development	GO:0048738	48	0.129
specification of symmetry	GO:0009799	204	0.129
multi organism process	GO:0051704	134	0.128
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.127
negative regulation of developmental process	GO:0051093	65	0.127	Mouse
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.126	Mouse
renal system development	GO:0072001	94	0.126
developmental cell growth	GO:0048588	52	0.124
taxis	GO:0042330	109	0.124	Mouse
cellular response to oxygen levels	GO:0071453	1	0.123
cell proliferation in dorsal spinal cord	GO:0010456	2	0.122
regulation of catenin import into nucleus	GO:0035412	2	0.120
extrinsic apoptotic signaling pathway	GO:0097191	3	0.120
single organism localization	GO:1902578	225	0.120
neuron projection guidance	GO:0097485	86	0.120	Mouse
regulation of rna metabolic process	GO:0051252	224	0.118
hypothalamus cell differentiation	GO:0021979	4	0.117	Zebrafish
regulation of cell cycle	GO:0051726	52	0.114	Zebrafish
negative regulation of cell fate specification	GO:0009996	11	0.114
negative regulation of protein serine threonine kinase activity	GO:0071901	2	0.113
morphogenesis of embryonic epithelium	GO:0016331	30	0.113
embryonic epithelial tube formation	GO:0001838	17	0.113
erk1 and erk2 cascade	GO:0070371	4	0.113
cerebellar granular layer formation	GO:0021684	3	0.113
positive regulation of defense response	GO:0031349	9	0.112
negative regulation of gene expression	GO:0010629	65	0.112
epithelial cell differentiation	GO:0030855	116	0.111
aging	GO:0007568	2	0.111
retina morphogenesis in camera type eye	GO:0060042	79	0.111
cellular response to organic substance	GO:0071310	105	0.110
determination of heart left right asymmetry	GO:0061371	117	0.110
immune response	GO:0006955	28	0.110
intracellular signal transduction	GO:0035556	85	0.110
striated muscle cell differentiation	GO:0051146	129	0.108
macromolecule modification	GO:0043412	111	0.108
negative regulation of rna metabolic process	GO:0051253	48	0.107
multicellular organismal metabolic process	GO:0044236	2	0.107
neuroblast differentiation	GO:0014016	1	0.107
gastrulation	GO:0007369	208	0.107	Zebrafish
photoreceptor cell differentiation	GO:0046530	55	0.106
branching morphogenesis of an epithelial tube	GO:0048754	15	0.105	Mouse
regulation of gastrulation	GO:0010470	24	0.105
localization of cell	GO:0051674	244	0.105
regulation of protein metabolic process	GO:0051246	56	0.105
cartilage condensation	GO:0001502	3	0.104
vasculogenesis	GO:0001570	41	0.104	Zebrafish
cranial nerve development	GO:0021545	42	0.104
embryonic viscerocranium morphogenesis	GO:0048703	52	0.104
embryonic skeletal joint development	GO:0072498	3	0.103
positive regulation of jun kinase activity	GO:0043507	2	0.102
eye photoreceptor cell development	GO:0042462	30	0.101
system process	GO:0003008	185	0.101
negative regulation of striated muscle tissue development	GO:0045843	2	0.101
sex determination	GO:0007530	1	0.100
midbrain hindbrain boundary development	GO:0030917	23	0.100
kidney epithelium development	GO:0072073	23	0.099
regulation of protein targeting	GO:1903533	2	0.098
forebrain anterior posterior pattern specification	GO:0021797	3	0.098
cerebellar granular layer morphogenesis	GO:0021683	3	0.098
positive regulation of neurogenesis	GO:0050769	24	0.098
regulation of cell cell adhesion	GO:0022407	13	0.097
regulation of developmental growth	GO:0048638	38	0.097
cellular response to nutrient levels	GO:0031669	2	0.097
regulation of organelle organization	GO:0033043	29	0.097
canonical wnt signaling pathway	GO:0060070	48	0.096
regulation of protein import into nucleus	GO:0042306	2	0.096
positive regulation of erk1 and erk2 cascade	GO:0070374	2	0.096
regulation of biological quality	GO:0065008	263	0.093
immune effector process	GO:0002252	23	0.093
negative regulation of protein kinase activity	GO:0006469	4	0.092
spinal cord development	GO:0021510	46	0.092
striated muscle tissue development	GO:0014706	110	0.092
positive regulation of developmental process	GO:0051094	50	0.091
axis specification	GO:0009798	43	0.091
morphogenesis of a branching structure	GO:0001763	21	0.090	Mouse
response to mechanical stimulus	GO:0009612	24	0.089
pons development	GO:0021548	11	0.088
regulation of binding	GO:0051098	3	0.088
optic placode formation	GO:0001743	4	0.087
axonogenesis	GO:0007409	152	0.087	Mouse
cell cycle process	GO:0022402	53	0.087
regulation of growth	GO:0040008	42	0.085
regulation of cell motility	GO:2000145	46	0.085
positive regulation of histone deacetylation	GO:0031065	1	0.085
cell aggregation	GO:0098743	3	0.083
developmental growth involved in morphogenesis	GO:0060560	86	0.083
nuclear transport	GO:0051169	4	0.083
negative regulation of endodermal cell fate specification	GO:0042664	8	0.083
negative regulation of transcription dna templated	GO:0045892	45	0.082
wnt signaling pathway	GO:0016055	80	0.081
positive regulation of rna biosynthetic process	GO:1902680	57	0.080
primitive hemopoiesis	GO:0060215	27	0.080	Zebrafish
embryonic camera type eye formation	GO:0060900	10	0.080
regulation of cell development	GO:0060284	100	0.080
negative regulation of growth	GO:0045926	10	0.079
epithelial cell development	GO:0002064	42	0.079
nucleobase containing compound biosynthetic process	GO:0034654	205	0.078
epidermal cell differentiation	GO:0009913	36	0.078
liver development	GO:0001889	96	0.077
phagocytosis	GO:0006909	3	0.077
neural crest cell migration	GO:0001755	42	0.077
regulation of ectodermal cell fate specification	GO:0042665	2	0.076
ectodermal placode formation	GO:0060788	26	0.076
cellular response to lipid	GO:0071396	39	0.076
regulation of molecular function	GO:0065009	70	0.076
regulation of macromolecule metabolic process	GO:0060255	317	0.076
negative regulation of map kinase activity	GO:0043407	2	0.075
regulation of cardiac muscle tissue development	GO:0055024	1	0.075
hindbrain formation	GO:0021576	3	0.075
rhombomere development	GO:0021546	19	0.074
cardiac muscle cell differentiation	GO:0055007	30	0.074
hindbrain morphogenesis	GO:0021575	22	0.074
negative regulation of leukocyte chemotaxis	GO:0002689	3	0.074
cellular amino acid metabolic process	GO:0006520	7	0.074
morphogenesis of an epithelial sheet	GO:0002011	49	0.074
gliogenesis	GO:0042063	45	0.074
response to other organism	GO:0051707	97	0.073
retina development in camera type eye	GO:0060041	146	0.073
protein localization to nucleus	GO:0034504	3	0.073
primary neural tube formation	GO:0014020	1	0.073
artery morphogenesis	GO:0048844	14	0.072
chemotaxis	GO:0006935	104	0.072	Mouse
regulation of protein localization to nucleus	GO:1900180	2	0.072
embryonic retina morphogenesis in camera type eye	GO:0060059	22	0.072
transcription dna templated	GO:0006351	181	0.072
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	6	0.072
kupffer s vesicle development	GO:0070121	50	0.071
cellular response to endogenous stimulus	GO:0071495	68	0.070
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.070
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.070
negative regulation of cell migration	GO:0030336	17	0.069
phosphorylation	GO:0016310	69	0.069
somitogenesis	GO:0001756	87	0.069
female gonad development	GO:0008585	4	0.069
rna biosynthetic process	GO:0032774	181	0.069
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.068
female sex differentiation	GO:0046660	4	0.068
oxidation reduction process	GO:0055114	41	0.068
negative regulation of cell differentiation	GO:0045596	46	0.068
protein targeting to nucleus	GO:0044744	3	0.068
negative regulation of intracellular protein transport	GO:0090317	3	0.067
neuron recognition	GO:0008038	18	0.066
regulation of multicellular organism growth	GO:0040014	4	0.066
regulation of cytoplasmic transport	GO:1903649	4	0.066
bone remodeling	GO:0046849	2	0.066
glomerulus development	GO:0032835	27	0.065
cilium organization	GO:0044782	71	0.065
positive regulation of protein metabolic process	GO:0051247	23	0.065
dorsal ventral pattern formation	GO:0009953	125	0.065
appendage morphogenesis	GO:0035107	56	0.064
phosphate containing compound metabolic process	GO:0006796	108	0.064
apoptotic signaling pathway	GO:0097190	23	0.064
artery development	GO:0060840	22	0.063
cardiac cell fate commitment	GO:0060911	1	0.063
mesenchymal cell proliferation	GO:0010463	1	0.063
extrinsic apoptotic signaling pathway in absence of ligand	GO:0097192	1	0.063
axonal fasciculation	GO:0007413	11	0.062
positive regulation of cell death	GO:0010942	29	0.062
nephron development	GO:0072006	31	0.062
fibroblast growth factor receptor signaling pathway	GO:0008543	22	0.061
myeloid cell differentiation	GO:0030099	86	0.061	Zebrafish
negative regulation of protein localization to nucleus	GO:1900181	2	0.061
cellular response to organic cyclic compound	GO:0071407	38	0.061
fin development	GO:0033333	77	0.060
negative regulation of myeloid cell differentiation	GO:0045638	1	0.060
negative regulation of developmental growth	GO:0048640	9	0.060
transport	GO:0006810	220	0.059
determination of bilateral symmetry	GO:0009855	204	0.059
sensory system development	GO:0048880	76	0.059
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.058
heterocycle biosynthetic process	GO:0018130	215	0.058
organonitrogen compound metabolic process	GO:1901564	74	0.058
cellular component assembly involved in morphogenesis	GO:0010927	107	0.057
protein modification process	GO:0036211	100	0.057
regulation of cell morphogenesis	GO:0022604	42	0.057
muscle organ morphogenesis	GO:0048644	8	0.056
carboxylic acid metabolic process	GO:0019752	22	0.056
positive regulation of cell differentiation	GO:0045597	30	0.056
development of primary female sexual characteristics	GO:0046545	4	0.056
ectodermal cell fate specification	GO:0001715	2	0.055
proximal distal pattern formation	GO:0009954	1	0.055
photoreceptor cell development	GO:0042461	40	0.055
cellular component morphogenesis	GO:0032989	336	0.054	Mouse
positive regulation of signal transduction	GO:0009967	56	0.054
mitotic cell cycle process	GO:1903047	48	0.054
connective tissue development	GO:0061448	99	0.053
cellular protein modification process	GO:0006464	100	0.053
aorta development	GO:0035904	4	0.053
ectoderm development	GO:0007398	9	0.052
positive regulation of axon extension involved in axon guidance	GO:0048842	1	0.051
regulation of cell communication	GO:0010646	232	0.051
wound healing	GO:0042060	90	0.051
positive regulation of stress activated protein kinase signaling cascade	GO:0070304	3	0.051
regulation of neurogenesis	GO:0050767	87	0.050
erythrocyte differentiation	GO:0030218	54	0.050
cartilage development	GO:0051216	96	0.050
cellular response to extracellular stimulus	GO:0031668	2	0.050
neurological system process	GO:0050877	62	0.050
embryonic hemopoiesis	GO:0035162	53	0.050	Zebrafish
sexual reproduction	GO:0019953	36	0.050
regulation of organ morphogenesis	GO:2000027	35	0.049	Mouse
amide transport	GO:0042886	12	0.049
regulation of phosphate metabolic process	GO:0019220	43	0.049
positive regulation of oligodendrocyte differentiation	GO:0048714	1	0.049
positive regulation of glial cell differentiation	GO:0045687	1	0.048
negative regulation of molecular function	GO:0044092	23	0.048
vestibular receptor cell development	GO:0060118	3	0.048
positive regulation of programmed cell death	GO:0043068	29	0.047
anterior posterior axis specification	GO:0009948	20	0.047
rhombomere 5 development	GO:0021571	4	0.047
regulation of rna biosynthetic process	GO:2001141	213	0.047
single organism transport	GO:0044765	206	0.047
regulation of endothelial cell differentiation	GO:0045601	3	0.047
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.047
negative regulation of reproductive process	GO:2000242	3	0.046
fertilization	GO:0009566	3	0.046
tube formation	GO:0035148	25	0.046
regulation of localization	GO:0032879	104	0.046
regulation of chondrocyte differentiation	GO:0032330	1	0.046
negative regulation of cellular biosynthetic process	GO:0031327	55	0.045
single organism cellular localization	GO:1902580	46	0.045
determination of left right symmetry	GO:0007368	179	0.045
endoderm development	GO:0007492	49	0.044
negative regulation of fibroblast growth factor receptor signaling pathway	GO:0040037	6	0.044
olfactory placode development	GO:0071698	12	0.044
cell fate commitment	GO:0045165	99	0.044
lens fiber cell morphogenesis	GO:0070309	3	0.044
cell migration involved in heart development	GO:0060973	22	0.044
peripheral nervous system neuron axonogenesis	GO:0048936	13	0.043
pituitary gland development	GO:0021983	16	0.043
multicellular organismal reproductive process	GO:0048609	35	0.043
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.042
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.041
cell fate determination	GO:0001709	7	0.041

pea3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.205
connective tissue disease	DOID:65	0.205
dysostosis	DOID:1934	0.205
musculoskeletal system disease	DOID:17	0.205
bone disease	DOID:0080001	0.205
bone development disease	DOID:0080006	0.205

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