Danio rerio

17 known processes

ism1

isthmin 1

ism1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
nephron morphogenesisGO:007202820.407
regionalizationGO:00030022740.375
urogenital system developmentGO:0001655970.356
nephron tubule morphogenesisGO:007207810.338
immune system developmentGO:00025201910.336
cell surface receptor signaling pathwayGO:00071663250.310
gastrulationGO:00073692080.309
renal tubule morphogenesisGO:006133310.270
brain developmentGO:00074202930.230
cell morphogenesis involved in neuron differentiationGO:00486671630.230
larval developmentGO:000216420.229
head developmentGO:00603223030.211
angiogenesisGO:00015251580.198
response to external stimulusGO:00096052640.183
regulation of metabolic processGO:00192223590.174
anterior posterior pattern specificationGO:00099521520.158
regulation of stem cell differentiationGO:200073640.150
vasculature developmentGO:00019442780.149
nucleobase containing compound metabolic processGO:00061392740.142
organic cyclic compound metabolic processGO:19013603010.137
regulation of epithelial cell proliferationGO:005067830.135
heterocycle metabolic processGO:00464832900.132
organelle organizationGO:00069962270.126
optic placode formationGO:000174340.125
regulation of wnt signaling pathway involved in digestive tract morphogenesisGO:200005620.120
regulation of gene expressionGO:00104682650.120
positive regulation of canonical wnt signaling pathwayGO:009026340.119
nitrogen compound metabolic processGO:00068073190.115
negative regulation of stem cell differentiationGO:200073720.113
sequestering of metal ionGO:005123830.112
cellular component morphogenesisGO:00329893360.112
mesoderm formationGO:0001707430.112
calcium ion transport into cytosolGO:006040230.111
nephron epithelium morphogenesisGO:007208810.110
kidney developmentGO:0001822920.107
appendage developmentGO:0048736800.107
negative regulation of sequestering of calcium ionGO:005128340.107
nucleobase containing compound biosynthetic processGO:00346542050.107
epithelial tube morphogenesisGO:00605621480.107
regulation of cellular metabolic processGO:00313233200.105
cellular macromolecule metabolic processGO:00442603910.104
negative regulation of biological processGO:00485193040.103
regulation of biological qualityGO:00650082630.100
cellular response to external stimulusGO:007149620.099
tube morphogenesisGO:00352393490.097
single organism organelle organizationGO:19025891990.097
embryonic eye morphogenesisGO:0048048300.096
digestive tract morphogenesisGO:00485462310.096
biosynthetic processGO:00090582940.096
tissue regenerationGO:0042246740.096
pronephric glomerulus developmentGO:0039021130.095
regulation of nucleobase containing compound metabolic processGO:00192192500.094
gene expressionGO:00104672520.094
regulation of anterior head developmentGO:200074220.093
response to carbohydrateGO:000974330.092
extrinsic apoptotic signaling pathwayGO:009719130.091
blood vessel developmentGO:00015682460.089
embryo development ending in birth or egg hatchingGO:00097922710.087
negative regulation of cellular processGO:00485232830.087
regulation of cellular response to growth factor stimulusGO:0090287350.086
nucleic acid metabolic processGO:00903042440.085
regulation of wnt signaling pathway calcium modulating pathwayGO:000859130.084
tube formationGO:0035148250.084
digestive system developmentGO:00551232890.083
negative regulation of anterior neural cell fate commitment of the neural plateGO:002200110.081
sensory organ morphogenesisGO:00905962000.081
type b pancreatic cell developmentGO:000332340.080
homeostatic processGO:00425921420.078
cellular nitrogen compound biosynthetic processGO:00442712180.077
cellular nitrogen compound metabolic processGO:00346412900.076
specification of organ identityGO:001009220.076
mesoderm developmentGO:0007498880.074
cell cycle processGO:0022402530.073
response to stressGO:00069502630.073
sequestering of calcium ionGO:005120830.072
midbrain hindbrain boundary developmentGO:0030917230.072
ear developmentGO:00435831270.071
wnt signaling pathway involved in digestive tract morphogenesisGO:004433340.069
anterior head developmentGO:009706520.068
regulation of macromolecule metabolic processGO:00602553170.068
hematopoietic or lymphoid organ developmentGO:00485341910.067
positive regulation of cell deathGO:0010942290.067
epithelial cell developmentGO:0002064420.067
regulation of sequestering of calcium ionGO:005128240.066
epithelial cell proliferation involved in liver morphogenesisGO:007257520.066
hemopoiesisGO:00300971830.066
cellular response to extracellular stimulusGO:003166820.066
regulation of cellular biosynthetic processGO:00313262450.065
gastrulation with mouth forming secondGO:0001702440.065
positive regulation of cellular processGO:00485222010.065
thrombocyte differentiationGO:000257440.064
somite developmentGO:0061053960.064
hindbrain morphogenesisGO:0021575220.064
chemical homeostasisGO:0048878490.063
negative regulation of mapk cascadeGO:004340940.063
cellular carbohydrate metabolic processGO:004426240.062
cytosolic calcium ion transportGO:006040130.062
transcription dna templatedGO:00063511810.062
release of sequestered calcium ion into cytosolGO:005120930.062
cellular aromatic compound metabolic processGO:00067252950.062
non canonical wnt signaling pathwayGO:0035567130.061
stem cell differentiationGO:00488631170.061
notochord developmentGO:0030903540.060
maintenance of locationGO:005123540.058
cell fate commitmentGO:0045165990.058
endoderm formationGO:0001706290.058
regulation of cell communicationGO:00106462320.057
protein localization to nucleusGO:003450430.056
signal transductionGO:00071654550.056
appendage morphogenesisGO:0035107560.056
stem cell maintenanceGO:001982740.056
hepatocyte proliferationGO:007257420.055
response to biotic stimulusGO:0009607970.055
sensory organ developmentGO:00074233930.054
neural tube patterningGO:0021532330.054
organic cyclic compound biosynthetic processGO:19013622230.054
growthGO:00400071740.054
pronephros developmentGO:0048793690.053
pronephric nephron developmentGO:0039019140.053
wnt signaling pathwayGO:0016055800.053
cardiocyte differentiationGO:0035051440.053
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.053
nuclear transportGO:005116940.053
nucleocytoplasmic transportGO:000691340.052
response to chemicalGO:00422213200.051
cellular amino acid metabolic processGO:000652070.051
nuclear importGO:005117030.050
protein targeting to nucleusGO:004474430.050
hard palate developmentGO:006002240.049
programmed cell deathGO:00125011190.049
mesenchymal cell proliferationGO:001046310.048
response to hexoseGO:000974630.048
embryonic limb morphogenesisGO:003032620.048
neural tube developmentGO:0021915620.048
cellular biosynthetic processGO:00442492860.046
negative regulation of epithelial cell proliferationGO:005068010.046
single organism metabolic processGO:00447102170.045
positive regulation of biological processGO:00485182530.045
aromatic compound biosynthetic processGO:00194382170.045
neuron projection morphogenesisGO:00488121610.045
apoptotic process involved in developmentGO:190274220.044
inner ear morphogenesisGO:0042472630.043
epidermis developmentGO:0008544480.043
hindbrain formationGO:002157630.043
cellular macromolecule biosynthetic processGO:00346452240.043
formation of primary germ layerGO:0001704620.042
negative regulation of map kinase activityGO:004340720.042
positive regulation of gene expressionGO:0010628710.042
renal system developmentGO:0072001940.041
cellular response to chemical stimulusGO:00708871570.040
dorsal ventral pattern formationGO:00099531250.040
cell cycleGO:0007049930.040
post anal tail morphogenesisGO:0036342190.040
mediolateral intercalationGO:006003130.040
neural plate developmentGO:0001840100.040
positive regulation of epithelial cell proliferationGO:005067910.039
cellular response to organic substanceGO:00713101050.039
peptide transportGO:001583310.039
pancreas developmentGO:0031016840.038
positive regulation of programmed cell deathGO:0043068290.038
regulation of peptidase activityGO:0052547230.038
protein importGO:001703830.038
photoreceptor cell fate commitmentGO:004655210.037
mesodermal cell differentiationGO:0048333210.037
ear morphogenesisGO:0042471640.037
epithelial cell morphogenesisGO:000338220.037
spinal cord anterior posterior patterningGO:002151210.036
cell part morphogenesisGO:00329902460.036
inner ear developmentGO:00488391260.036
bmp signaling pathwayGO:0030509520.036
interaction with hostGO:005170140.036
nephron epithelium developmentGO:0072009160.036
regulation of biosynthetic processGO:00098892500.035
digestive tract developmentGO:00485652650.035
fin regenerationGO:0031101510.035
response to external biotic stimulusGO:0043207970.035
neuronal stem cell maintenanceGO:009715020.034
hepatic duct developmentGO:006101120.034
regulation of macromolecule biosynthetic processGO:00105562250.033
carbohydrate homeostasisGO:003350010.033
amine metabolic processGO:000930820.033
somitogenesisGO:0001756870.033
axon developmentGO:00615641660.032
regulation of hydrolase activityGO:0051336280.032
camera type eye morphogenesisGO:00485931080.032
kidney morphogenesisGO:0060993150.032
establishment of protein localization to organelleGO:007259440.032
organism emergence from protective structureGO:007168440.032
embryonic organ developmentGO:00485683810.032
reactive oxygen species metabolic processGO:007259360.032
endoderm developmentGO:0007492490.031
macromolecule biosynthetic processGO:00090592270.031
dorsal ventral axis specificationGO:0009950140.031
positive regulation of cytosolic calcium ion concentrationGO:000720440.031
positive regulation of blood circulationGO:190352420.030
primary neural tube formationGO:001402010.030
optic placode formation involved in camera type eye formationGO:004661930.030
cell morphogenesis involved in differentiationGO:00009041950.030
epidermal cell differentiationGO:0009913360.030
renal tubule developmentGO:006132650.030
regulation of extrinsic apoptotic signaling pathwayGO:200123630.030
determination of bilateral symmetryGO:00098552040.030
cell projection morphogenesisGO:00488582440.030
gall bladder developmentGO:006101010.029
mesenchyme developmentGO:00604851270.029
immune system processGO:00023762410.029
regulation of heart growthGO:006042020.029
embryonic heart tube morphogenesisGO:00031431080.029
somatic stem cell maintenanceGO:003501910.029
cation homeostasisGO:0055080330.029
protein import into nucleusGO:000660630.028
response to monosaccharideGO:003428430.028
mitotic cell cycleGO:0000278640.028
negative regulation of canonical wnt signaling pathwayGO:0090090210.028
positive regulation of rna biosynthetic processGO:1902680570.028
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.028
central nervous system developmentGO:00074173870.027
protein metabolic processGO:00195381830.027
developmental growthGO:00485891660.027
regulation of circadian rhythmGO:004275240.027
fin morphogenesisGO:0033334530.027
embryonic camera type eye developmentGO:0031076290.026
canonical wnt signaling pathway involved in heart developmentGO:006131610.026
regulation of reactive oxygen species metabolic processGO:200037720.026
cell morphogenesisGO:00009022890.026
embryonic epithelial tube formationGO:0001838170.026
ribosomal small subunit biogenesisGO:004227420.026
tube closureGO:006060610.026
i kappab kinase nf kappab signalingGO:000724940.026
response to organic substanceGO:00100331530.026
negative regulation of protein serine threonine kinase activityGO:007190120.025
negative regulation of axon extension involved in axon guidanceGO:004884310.025
regulation of i kappab kinase nf kappab signalingGO:004312240.025
regulation of cellular ketone metabolic processGO:001056570.025
convergent extensionGO:00600261180.025
morphogenesis of a branching epitheliumGO:0061138160.025
endocrine system developmentGO:0035270650.025
negative regulation of multicellular organismal processGO:0051241690.025
mesoderm morphogenesisGO:0048332510.025
regulation of multicellular organismal processGO:00512392770.024
nephron tubule developmentGO:007208040.024
glucose homeostasisGO:004259310.024
branching morphogenesis of an epithelial tubeGO:0048754150.024
nucleic acid templated transcriptionGO:00976591810.024
fibroblast growth factor receptor signaling pathwayGO:0008543220.024
response to other organismGO:0051707970.023
canonical wnt signaling pathwayGO:0060070480.023
morphogenesis of an epithelial foldGO:006057110.023
phosphate containing compound metabolic processGO:00067961080.023
nephric duct morphogenesisGO:007217870.023
cellular localizationGO:0051641970.023
ectodermal placode developmentGO:0071696370.023
morphogenesis of an epitheliumGO:00020093330.023
otolith developmentGO:0048840320.023
muscle structure developmentGO:00610611960.023
spemann organizer formationGO:0060061100.022
embryonic camera type eye formationGO:0060900100.022
regulation of developmental processGO:00507932470.022
rna metabolic processGO:00160702190.022
regulation of carbohydrate metabolic processGO:000610940.022
embryonic organ morphogenesisGO:00485622740.022
regulation of protein catabolic processGO:004217610.022
regulation of tube sizeGO:003515020.022
regulation of rna metabolic processGO:00512522240.022
positive regulation of peptidase activityGO:0010952100.022
positive regulation of nucleic acid templated transcriptionGO:1903508570.022
heterocycle biosynthetic processGO:00181302150.022
negative regulation of apoptotic processGO:0043066550.021
intracellular signal transductionGO:0035556850.021
establishment of localizationGO:00512342440.021
multi organism processGO:00517041340.021
response to glucoseGO:000974930.021
eye field cell fate commitment involved in camera type eye formationGO:006089830.021
g protein coupled receptor signaling pathwayGO:0007186740.021
regulation of cell cycleGO:0051726520.021
deathGO:00162651210.021
regulation of protein targetingGO:190353320.021
regulation of cellular amine metabolic processGO:003323800.021
regulation of reproductive processGO:200024140.020
locomotionGO:00400113130.020
response to fibroblast growth factorGO:0071774220.020
cellular response to growth factor stimulusGO:0071363390.020
developmental inductionGO:0031128100.020
cellular amine metabolic processGO:004410620.020
regulation of signal transductionGO:00099662250.020
cellular response to nutrient levelsGO:003166920.020
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.020
positive regulation of cell killingGO:003134320.020
positive regulation of cellular metabolic processGO:0031325940.020
regulation of cysteine type endopeptidase activityGO:2000116210.020
positive regulation of epithelial cell differentiationGO:003085820.020
hormone transportGO:000991420.020
spindle assemblyGO:005122520.019
cell deathGO:00082191210.019
positive regulation of cellular biosynthetic processGO:0031328680.019
neuron developmentGO:00486662620.019
striated muscle tissue developmentGO:00147061100.019
type b pancreatic cell differentiationGO:000330980.019
regulation of canonical wnt signaling pathwayGO:0060828340.019
specification of symmetryGO:00097992040.019
metal ion homeostasisGO:0055065260.019
tissue remodelingGO:004877140.019
skin developmentGO:0043588540.019
cellular response to fibroblast growth factor stimulusGO:0044344220.019
regulation of cellular amino acid metabolic processGO:000652100.019
regulation of organ growthGO:004662030.018
positive regulation of cell adhesionGO:004578510.018
negative regulation of catabolic processGO:000989530.018
determination of dorsal ventral asymmetryGO:0048262340.018
kidney epithelium developmentGO:0072073230.018
regulation of cell activationGO:005086510.018
b cell differentiationGO:003018310.018
cellular response to stressGO:0033554620.018
forebrain developmentGO:0030900960.018
regulation of proteolysisGO:0030162240.018
positive regulation of cellular amine metabolic processGO:003324000.018
organonitrogen compound metabolic processGO:1901564740.018
glucose importGO:004632320.018
response to growth factorGO:0070848390.018
mesodermal cell fate commitmentGO:0001710140.018
cell cell signaling involved in cell fate commitmentGO:0045168120.018
fin developmentGO:0033333770.018
positive regulation of nucleobase containing compound metabolic processGO:0045935690.018
blood vessel morphogenesisGO:00485142160.018
smooth muscle contractionGO:000693920.017
regulation of protein import into nucleusGO:004230620.017
stem cell fate commitmentGO:004886510.017
collateral sprouting in absence of injuryGO:004866940.017
ion homeostasisGO:0050801410.017
organelle assemblyGO:00709251100.017
axonal fasciculationGO:0007413110.017
heart morphogenesisGO:00030071560.017
regulation of organ morphogenesisGO:2000027350.017
organic acid metabolic processGO:0006082310.017
cellular response to starvationGO:000926710.017
regulation of nucleocytoplasmic transportGO:004682220.017
wnt signaling pathway planar cell polarity pathwayGO:006007140.017
divalent inorganic cation homeostasisGO:0072507220.016
regulation of synapse assemblyGO:005196330.016
regulation of epithelial to mesenchymal transitionGO:001071730.016
olfactory lobe developmentGO:002198840.016
metencephalon developmentGO:0022037270.016
heart joggingGO:0003146400.016
embryonic appendage morphogenesisGO:0035113300.016
small molecule metabolic processGO:0044281770.016
habenula developmentGO:002198690.016
sensory system developmentGO:0048880760.016
positive regulation of stress activated mapk cascadeGO:003287430.016
regulation of bmp signaling pathwayGO:0030510390.016
female gonad developmentGO:000858540.016
paraxial mesoderm formationGO:004834120.016
regulation of primary metabolic processGO:00800903110.016
embryonic pectoral fin morphogenesisGO:0035118240.016
nephron developmentGO:0072006310.016
eye morphogenesisGO:00485921440.016
arterial endothelial cell differentiationGO:006084220.016
regulation of nucleic acid templated transcriptionGO:19035062130.016
regulation of biomineral tissue developmentGO:007016720.016
neuron projection guidanceGO:0097485860.015
organic substance biosynthetic processGO:19015762890.015
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.015
hematopoietic stem cell differentiationGO:0060218200.015
cerebellum morphogenesisGO:0021587100.015
organ formationGO:0048645170.015
somatic muscle developmentGO:000752540.015
regulation of gastrulationGO:0010470240.015
defense response to other organismGO:0098542330.015
heart loopingGO:0001947940.015
central nervous system neuron differentiationGO:0021953740.015
establishment of localization in cellGO:0051649770.015
phagocytosisGO:000690930.015
regulation of endopeptidase activityGO:0052548230.015
rna biosynthetic processGO:00327741810.015
positive regulation of cellular amino acid metabolic processGO:004576400.015
regulation of blood vessel sizeGO:005088020.015
negative regulation of developmental processGO:0051093650.015
cell substrate junction assemblyGO:000704420.015
negative regulation of kinase activityGO:003367340.015
single organism reproductive processGO:0044702400.015
organelle localizationGO:0051640490.015
morphogenesis of a branching structureGO:0001763210.015
dorsal convergenceGO:0060030140.015
regulation of peptidyl tyrosine phosphorylationGO:005073010.015
embryonic camera type eye morphogenesisGO:0048596190.015
wound healingGO:0042060900.015
zymogen activationGO:003163830.014
regulation of organelle organizationGO:0033043290.014
cell fate commitment involved in formation of primary germ layerGO:0060795260.014
cell differentiation involved in kidney developmentGO:0061005130.014
regulation of programmed cell deathGO:00430671010.014
cell surface receptor signaling pathway involved in heart developmentGO:0061311200.014
rostrocaudal neural tube patterningGO:0021903290.014
cell proliferationGO:0008283800.014
negative regulation of protein kinase activityGO:000646940.014
ion transportGO:00068111140.014
phosphorylationGO:0016310690.014
regulation of cytoplasmic transportGO:190364940.014
epithelial cell proliferationGO:0050673170.014
positive regulation of striated muscle cell differentiationGO:005115510.014
signal transduction in absence of ligandGO:003803410.014
camera type eye developmentGO:00430102220.014
protein stabilizationGO:005082120.014
positive regulation of apoptotic processGO:0043065290.014
mitotic cell cycle processGO:1903047480.014
cardiac muscle tissue developmentGO:0048738480.014
reproductive processGO:0022414400.014
heart developmentGO:00075073130.014
oxoacid metabolic processGO:0043436310.014
multicellular organism reproductionGO:0032504350.014
nitric oxide metabolic processGO:004620920.013
apoptotic process involved in morphogenesisGO:006056120.013
killing of cells in other organism involved in symbiotic interactionGO:005188310.013
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathwayGO:002200210.013
regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043281200.013
cerebellum formationGO:002158820.013
positive regulation of transportGO:005105020.013
phagocytosis engulfmentGO:000691110.013
nephric duct developmentGO:0072176130.013
negative regulation of response to stimulusGO:00485851040.013
regulation of rho protein signal transductionGO:003502320.013
negative regulation of mitosisGO:004583930.013
regulation of cellular component organizationGO:0051128860.013
cellular homeostasisGO:0019725260.013
convergent extension involved in gastrulationGO:0060027710.013
regulation of cell migrationGO:0030334400.013
regulation of wnt signaling pathwayGO:0030111530.013
regulation of metal ion transportGO:001095940.013
gland developmentGO:00487321430.013
negative regulation of bmp signaling pathwayGO:0030514130.013
carboxylic acid metabolic processGO:0019752220.013
positive regulation of cell communicationGO:0010647560.013
positive regulation of hydrolase activityGO:0051345130.013
vestibular receptor cell differentiationGO:006011430.012
ectoderm developmentGO:000739890.012
meiotic chromosome segregationGO:004513230.012
cartilage developmentGO:0051216960.012
single organism localizationGO:19025782250.012
regulation of protein localization to nucleusGO:190018020.012
regenerationGO:0031099910.012
enteroendocrine cell differentiationGO:003588390.012
regulation of response to stimulusGO:00485832690.012
heart formationGO:0060914130.012
skeletal system morphogenesisGO:00487051020.012
carbohydrate derivative metabolic processGO:1901135610.012
negative regulation of wnt signaling pathwayGO:0030178300.012
hypothalamus developmentGO:0021854140.012
cell growthGO:0016049570.012
multicellular organismal homeostasisGO:0048871290.012
regulation of axon guidanceGO:190266780.012
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.012
cellular response to molecule of bacterial originGO:007121930.012
fourth ventricle developmentGO:002159280.012
endodermal cell fate commitmentGO:0001711180.012
segmentationGO:0035282970.012
regulation of transcription dna templatedGO:00063552130.012
hormone secretionGO:004687920.012
regulation of rna biosynthetic processGO:20011412130.012
muscle tissue developmentGO:00605371100.012
cell projection organizationGO:00300302840.012
anatomical structure homeostasisGO:0060249360.012
regulation of cellular component movementGO:0051270550.012
cell migration involved in gastrulationGO:0042074790.012
chordate embryonic developmentGO:00430092710.012
killing of cells of other organismGO:003164010.012
autophagyGO:000691440.012
phosphorus metabolic processGO:00067931090.011
cell fate specificationGO:0001708680.011
lateral line system developmentGO:0048925760.011
endothelial cell fate commitmentGO:006083930.011
reactive nitrogen species metabolic processGO:200105700.011
chondrocyte differentiationGO:000206270.011
muscle cell differentiationGO:00426921390.011
positive regulation of metabolic processGO:00098931080.011
endodermal cell differentiationGO:0035987190.011
unidimensional cell growthGO:000982650.011
sensory perception of chemical stimulusGO:000760630.011
regulation of nitrogen compound metabolic processGO:00511712510.011
lateral mesoderm developmentGO:0048368230.011
single organism intracellular transportGO:1902582250.011
hatchingGO:003518840.011
negative regulation of signal transductionGO:0009968940.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.011
nuclear exportGO:005116810.011
diencephalon developmentGO:0021536580.011
regulation of cell deathGO:00109411030.011
regulation of multicellular organismal developmentGO:20000262230.011
neuron projection developmentGO:00311751800.011
regulation of cell differentiationGO:00455951420.011
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.011
cell killingGO:000190620.011
regulation of calcium ion transportGO:005192420.011

ism1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
cancerDOID:16200.036
disease of cellular proliferationDOID:1456600.036
disease of anatomical entityDOID:700.020
organ system cancerDOID:005068600.017