IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

atp5a1

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

(Aliases: zgc:154103)

Entrez: 553755
ZFIN: ZDB-GENE-060201-1
Ensembl: ENSDARG00000010149
UniProtKB: Q08BA1

Process Predictions
Disease Predictions

atp5a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
cellular respiration	GO:0045333	3	0.241
larval development	GO:0002164	2	0.236	Worm
inorganic cation transmembrane transport	GO:0098662	50	0.227	Mouse
carbohydrate derivative metabolic process	GO:1901135	61	0.213	Human Mouse
cation transmembrane transport	GO:0098655	65	0.189	Mouse
purine containing compound metabolic process	GO:0072521	29	0.189	Human Mouse
ion transport	GO:0006811	114	0.152	Mouse
cellular nitrogen compound metabolic process	GO:0034641	290	0.148	Human Mouse
ribonucleotide metabolic process	GO:0009259	27	0.136	Human Mouse
aging	GO:0007568	2	0.134	Worm
purine nucleotide metabolic process	GO:0006163	27	0.127	Human Mouse
mitochondrion organization	GO:0007005	4	0.122
programmed cell death	GO:0012501	119	0.114	Worm
nitrogen compound metabolic process	GO:0006807	319	0.111	Human Mouse
ion transmembrane transport	GO:0034220	91	0.108	Mouse
reactive oxygen species metabolic process	GO:0072593	6	0.091
cellular aromatic compound metabolic process	GO:0006725	295	0.090	Human Mouse
central nervous system development	GO:0007417	387	0.085
maintenance of location	GO:0051235	4	0.075
organonitrogen compound metabolic process	GO:1901564	74	0.074	Human Mouse
proteasomal protein catabolic process	GO:0010498	2	0.072
oxidative phosphorylation	GO:0006119	1	0.072
organic cyclic compound metabolic process	GO:1901360	301	0.070	Human Mouse
ribose phosphate metabolic process	GO:0019693	27	0.069	Human Mouse
regulation of membrane potential	GO:0042391	23	0.065
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.064	Human Mouse
single organism biosynthetic process	GO:0044711	71	0.064
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.060
nucleobase containing compound metabolic process	GO:0006139	274	0.060	Human Mouse
energy derivation by oxidation of organic compounds	GO:0015980	5	0.060
multicellular organism growth	GO:0035264	4	0.057
intracellular signal transduction	GO:0035556	85	0.054
organelle organization	GO:0006996	227	0.054
apoptotic process	GO:0006915	116	0.053	Worm
purine ribonucleoside monophosphate metabolic process	GO:0009167	5	0.052	Human Mouse
cell death	GO:0008219	121	0.051	Worm
embryo development ending in birth or egg hatching	GO:0009792	271	0.050	Worm
lipid storage	GO:0019915	1	0.049
single organism metabolic process	GO:0044710	217	0.046	Human Mouse
carbohydrate derivative biosynthetic process	GO:1901137	43	0.046
guanosine containing compound metabolic process	GO:1901068	4	0.045
protein acetylation	GO:0006473	2	0.045
neurotransmitter transport	GO:0006836	2	0.044
response to stress	GO:0006950	263	0.044
regulation of macromolecule metabolic process	GO:0060255	317	0.044
small molecule metabolic process	GO:0044281	77	0.042	Human Mouse
purine containing compound biosynthetic process	GO:0072522	20	0.042
positive regulation of cytokine production	GO:0001819	2	0.041
transport	GO:0006810	220	0.040	Mouse
ribonucleoside metabolic process	GO:0009119	11	0.039	Human Mouse
gtp metabolic process	GO:0046039	4	0.039
establishment of localization	GO:0051234	244	0.038	Mouse
head development	GO:0060322	303	0.038
atp catabolic process	GO:0006200	4	0.037	Human Mouse
cation transport	GO:0006812	81	0.036	Mouse
organic cyclic compound biosynthetic process	GO:1901362	223	0.035
inorganic ion transmembrane transport	GO:0098660	57	0.034	Mouse
nucleotide metabolic process	GO:0009117	28	0.034	Human Mouse
phosphate containing compound metabolic process	GO:0006796	108	0.034	Human Mouse
extrinsic apoptotic signaling pathway	GO:0097191	3	0.034
transmembrane transport	GO:0055085	120	0.034	Mouse
cellular component movement	GO:0006928	335	0.033
heterocycle biosynthetic process	GO:0018130	215	0.033
gtp catabolic process	GO:0006184	2	0.032
regulation of cellular response to oxidative stress	GO:1900407	2	0.032
cellular amide metabolic process	GO:0043603	4	0.031
hemopoiesis	GO:0030097	183	0.031
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.030
positive regulation of apoptotic signaling pathway	GO:2001235	1	0.030
electron transport chain	GO:0022900	2	0.029
oxoacid metabolic process	GO:0043436	31	0.029
nucleoside phosphate metabolic process	GO:0006753	28	0.028	Human Mouse
organic acid metabolic process	GO:0006082	31	0.028
carboxylic acid metabolic process	GO:0019752	22	0.027
proteolysis involved in cellular protein catabolic process	GO:0051603	3	0.027
regulation of response to stimulus	GO:0048583	269	0.026
nucleoside metabolic process	GO:0009116	11	0.026	Human Mouse
proteasome mediated ubiquitin dependent protein catabolic process	GO:0043161	2	0.026
ribonucleotide biosynthetic process	GO:0009260	20	0.026
anion transport	GO:0006820	38	0.026
regulation of protein complex assembly	GO:0043254	3	0.025
response to oxygen levels	GO:0070482	25	0.025
aromatic compound biosynthetic process	GO:0019438	217	0.025
nucleotide biosynthetic process	GO:0009165	21	0.025
peptide metabolic process	GO:0006518	1	0.025
nucleoside triphosphate biosynthetic process	GO:0009142	2	0.025
activation of mapk activity	GO:0000187	3	0.024
regulation of dna templated transcription in response to stress	GO:0043620	0	0.024
adult behavior	GO:0030534	2	0.024
nucleobase containing compound biosynthetic process	GO:0034654	205	0.024
response to external stimulus	GO:0009605	264	0.024
protein modification process	GO:0036211	100	0.023
ventricular cardiac muscle tissue development	GO:0003229	3	0.023
regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902175	2	0.023
signal transduction	GO:0007165	455	0.023
cellular biosynthetic process	GO:0044249	286	0.023
response to organic substance	GO:0010033	153	0.023
response to oxygen radical	GO:0000305	2	0.023
response to hypoxia	GO:0001666	25	0.023
multi organism process	GO:0051704	134	0.022
rna localization	GO:0006403	4	0.022
negative regulation of cytoplasmic transport	GO:1903650	2	0.022
cell proliferation	GO:0008283	80	0.022	Human
purine ribonucleoside metabolic process	GO:0046128	10	0.022	Human Mouse
modification dependent macromolecule catabolic process	GO:0043632	3	0.022
alpha amino acid metabolic process	GO:1901605	3	0.022
generation of neurons	GO:0048699	385	0.022
cell migration	GO:0016477	237	0.022
ubiquitin dependent protein catabolic process	GO:0006511	3	0.022
amine metabolic process	GO:0009308	2	0.022
regulation of reproductive process	GO:2000241	4	0.022
protein stabilization	GO:0050821	2	0.022
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.021
regulation of establishment of protein localization	GO:0070201	4	0.021
cell motility	GO:0048870	244	0.021
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.021	Human Mouse
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.021	Human Mouse
regulation of extrinsic apoptotic signaling pathway	GO:2001236	3	0.021
synaptic transmission cholinergic	GO:0007271	4	0.021
nuclear transport	GO:0051169	4	0.020
guanosine containing compound catabolic process	GO:1901069	2	0.020
oxidation reduction process	GO:0055114	41	0.020
localization of cell	GO:0051674	244	0.020
cellular protein catabolic process	GO:0044257	4	0.020
immune system process	GO:0002376	241	0.019
regulation of cytokine production	GO:0001817	3	0.019
response to biotic stimulus	GO:0009607	97	0.019
atp synthesis coupled electron transport	GO:0042773	1	0.019
regulation of biological quality	GO:0065008	263	0.019
cell surface receptor signaling pathway	GO:0007166	325	0.019
regulation of synaptic plasticity	GO:0048167	1	0.019
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.019
phosphorus metabolic process	GO:0006793	109	0.019	Human Mouse
purine ribonucleotide metabolic process	GO:0009150	27	0.019	Human Mouse
production of molecular mediator of immune response	GO:0002440	2	0.019
heterocycle catabolic process	GO:0046700	15	0.019	Human Mouse
anion transmembrane transport	GO:0098656	12	0.019
death	GO:0016265	121	0.019	Worm
single organism localization	GO:1902578	225	0.018	Mouse
organophosphate metabolic process	GO:0019637	37	0.018	Human Mouse
negative regulation of protein phosphorylation	GO:0001933	4	0.018
regulation of response to oxidative stress	GO:1902882	2	0.018
zymogen activation	GO:0031638	3	0.018
embryonic organ development	GO:0048568	381	0.018
cell aging	GO:0007569	2	0.018
regulation of binding	GO:0051098	3	0.017
ribonucleoside triphosphate biosynthetic process	GO:0009201	2	0.017
reactive oxygen species biosynthetic process	GO:1903409	1	0.017
gene expression	GO:0010467	252	0.017
negative regulation of nucleocytoplasmic transport	GO:0046823	2	0.017
autophagy	GO:0006914	4	0.017
cellular amino acid metabolic process	GO:0006520	7	0.017
lipid homeostasis	GO:0055088	3	0.017
dicarboxylic acid metabolic process	GO:0043648	1	0.017
regulation of signaling	GO:0023051	235	0.017
negative regulation of biological process	GO:0048519	304	0.017	Human
meiotic cell cycle process	GO:1903046	3	0.017
positive regulation of map kinase activity	GO:0043406	3	0.017
nucleocytoplasmic transport	GO:0006913	4	0.017
reproduction	GO:0000003	40	0.017	Worm
coenzyme biosynthetic process	GO:0009108	2	0.017
biosynthetic process	GO:0009058	294	0.017
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.017
developmental programmed cell death	GO:0010623	4	0.017
cellular transition metal ion homeostasis	GO:0046916	3	0.017
mitochondrial atp synthesis coupled electron transport	GO:0042775	1	0.016
regulation of autophagy	GO:0010506	3	0.016
immune system development	GO:0002520	191	0.016
regulation of programmed cell death	GO:0043067	101	0.016
carbohydrate homeostasis	GO:0033500	1	0.016
action potential	GO:0001508	19	0.016
purine nucleotide biosynthetic process	GO:0006164	20	0.016
heart morphogenesis	GO:0003007	156	0.016
negative regulation of protein transport	GO:0051224	3	0.016
actin filament based movement	GO:0030048	1	0.015
establishment of protein localization to organelle	GO:0072594	4	0.015
nucleic acid transport	GO:0050657	2	0.015
regulation of primary metabolic process	GO:0080090	311	0.015
cellular response to superoxide	GO:0071451	2	0.015
stem cell proliferation	GO:0072089	4	0.015
cell death in response to oxidative stress	GO:0036473	2	0.015
establishment of rna localization	GO:0051236	3	0.015
membrane hyperpolarization	GO:0060081	1	0.015
response to drug	GO:0042493	3	0.015
regulation of nucleoside metabolic process	GO:0009118	2	0.015
protein acylation	GO:0043543	3	0.015
spermatid differentiation	GO:0048515	2	0.015
regulation of protein ubiquitination	GO:0031396	3	0.015
regulation of intracellular protein transport	GO:0033157	3	0.015
multicellular organismal signaling	GO:0035637	22	0.015
branching morphogenesis of a nerve	GO:0048755	4	0.015
ion homeostasis	GO:0050801	41	0.015
neuron differentiation	GO:0030182	353	0.015
response to chemical	GO:0042221	320	0.014
behavior	GO:0007610	74	0.014
transcription from rna polymerase ii promoter	GO:0006366	80	0.014
system process	GO:0003008	185	0.014
nucleoside monophosphate catabolic process	GO:0009125	4	0.014	Human Mouse
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathway	GO:1902176	2	0.014
spermatid development	GO:0007286	2	0.014
nucleobase containing small molecule metabolic process	GO:0055086	32	0.014	Human Mouse
purine ribonucleotide biosynthetic process	GO:0009152	20	0.014
brain development	GO:0007420	293	0.014
response to wounding	GO:0009611	116	0.014
metal ion transport	GO:0030001	58	0.013
regulation of production of molecular mediator of immune response	GO:0002700	1	0.013
rna biosynthetic process	GO:0032774	181	0.013
cellular component assembly involved in morphogenesis	GO:0010927	107	0.013
glycosyl compound metabolic process	GO:1901657	11	0.013	Human Mouse
regulation of cellular amino acid metabolic process	GO:0006521	0	0.013
cellular response to oxygen levels	GO:0071453	1	0.013
cellular amine metabolic process	GO:0044106	2	0.013
regulation of muscle contraction	GO:0006937	3	0.013
muscle cell development	GO:0055001	115	0.013
regulation of oxidative stress induced cell death	GO:1903201	2	0.013
organophosphate biosynthetic process	GO:0090407	23	0.013
regulation of cell communication	GO:0010646	232	0.013
negative regulation of cellular catabolic process	GO:0031330	3	0.013
positive regulation of cellular amine metabolic process	GO:0033240	0	0.013
regulation of multicellular organism growth	GO:0040014	4	0.013
negative regulation of protein import into nucleus	GO:0042308	2	0.012
fatty acid transport	GO:0015908	1	0.012
heart contraction	GO:0060047	71	0.012
regulation of metabolic process	GO:0019222	359	0.012
regulation of cytoplasmic transport	GO:1903649	4	0.012
striated muscle cell development	GO:0055002	108	0.012
negative regulation of gene expression	GO:0010629	65	0.012
regulation of apoptotic process	GO:0042981	98	0.012
neurotransmitter secretion	GO:0007269	2	0.012
extrinsic apoptotic signaling pathway via death domain receptors	GO:0008625	1	0.012
regulation of blood pressure	GO:0008217	1	0.012
nucleoside triphosphate metabolic process	GO:0009141	9	0.012	Human Mouse
protein homooligomerization	GO:0051260	3	0.012
single organism organelle organization	GO:1902589	199	0.012
phospholipase c activating g protein coupled receptor signaling pathway	GO:0007200	2	0.012
striated muscle cell differentiation	GO:0051146	129	0.012
negative regulation of catabolic process	GO:0009895	3	0.012
glucose homeostasis	GO:0042593	1	0.011
negative regulation of kinase activity	GO:0033673	4	0.011
intrinsic apoptotic signaling pathway in response to oxidative stress	GO:0008631	2	0.011
purine nucleoside triphosphate biosynthetic process	GO:0009145	2	0.011
positive regulation of biological process	GO:0048518	253	0.011
cellular component morphogenesis	GO:0032989	336	0.011
monovalent inorganic cation transport	GO:0015672	42	0.011	Mouse
positive regulation of cellular catabolic process	GO:0031331	3	0.011
single organism transport	GO:0044765	206	0.011	Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stress	GO:0043619	0	0.011
cytoskeleton organization	GO:0007010	96	0.011
regulation of cell death	GO:0010941	103	0.011
apoptotic process involved in morphogenesis	GO:0060561	2	0.011
regulation of protein localization to nucleus	GO:1900180	2	0.011
regulation of protein binding	GO:0043393	3	0.011
ventricular cardiac muscle tissue morphogenesis	GO:0055010	2	0.011
protein localization to nucleus	GO:0034504	3	0.011
single organism nuclear import	GO:1902593	3	0.011
hematopoietic or lymphoid organ development	GO:0048534	191	0.011
regulation of cell activation	GO:0050865	1	0.011
regulation of purine nucleotide catabolic process	GO:0033121	2	0.011
purine ribonucleoside biosynthetic process	GO:0046129	2	0.011
apoptotic process involved in development	GO:1902742	2	0.011
regulation of blood vessel size	GO:0050880	2	0.011
regulation of signal transduction	GO:0009966	225	0.011
cellular catabolic process	GO:0044248	27	0.011	Human Mouse
purine ribonucleoside triphosphate biosynthetic process	GO:0009206	2	0.011
regulation of developmental process	GO:0050793	247	0.011
regulation of cellular amine metabolic process	GO:0033238	0	0.011
protein complex subunit organization	GO:0071822	46	0.011
oocyte maturation	GO:0001556	4	0.010
regulation of cellular ketone metabolic process	GO:0010565	7	0.010
organic cyclic compound catabolic process	GO:1901361	15	0.010	Human Mouse
membrane repolarization	GO:0086009	2	0.010
cellular response to oxygen radical	GO:0071450	2	0.010
posttranscriptional gene silencing	GO:0016441	3	0.010
sensory organ development	GO:0007423	393	0.010
regulation of protein catabolic process	GO:0042176	1	0.010
regulation of nucleotide catabolic process	GO:0030811	2	0.010
ribonucleoside biosynthetic process	GO:0042455	2	0.010
circulatory system process	GO:0003013	87	0.010
response to decreased oxygen levels	GO:0036293	25	0.010

atp5a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.245
inherited metabolic disorder	DOID:655	0.155
mitochondrial metabolism disease	DOID:700	0.155
disease of metabolism	DOID:0014667	0.155
leigh disease	DOID:3652	0.039
nervous system disease	DOID:863	0.037
muscular disease	DOID:0080000	0.020
muscle tissue disease	DOID:66	0.020
musculoskeletal system disease	DOID:17	0.020
disease of cellular proliferation	DOID:14566	0.019
organ system cancer	DOID:0050686	0.017
cancer	DOID:162	0.017
cardiovascular system disease	DOID:1287	0.016
neurodegenerative disease	DOID:1289	0.015
central nervous system disease	DOID:331	0.015
myopathy	DOID:423	0.013
intrinsic cardiomyopathy	DOID:0060036	0.013
cardiomyopathy	DOID:0050700	0.013
heart disease	DOID:114	0.013

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