IMP: Integrative Multi-species Prediction

Danio rerio

29 known processes

mafba

v-maf musculoaponeurotic fibrosarcoma oncogene family, protein B (avian)

(Aliases: wu:fc22d11,wu:fj82a09,val,kr,krml,kreisler,mafb)

ZFIN: ZDB-GENE-980526-515
Ensembl: ENSDARG00000017121
Entrez: 30210
UniProtKB: Q98UK5

Process Predictions
Disease Predictions

mafba biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
hematopoietic or lymphoid organ development	GO:0048534	191	0.993	Human Mouse
regulation of cell differentiation	GO:0045595	142	0.983	Human
cell surface receptor signaling pathway	GO:0007166	325	0.982
regulation of multicellular organismal development	GO:2000026	223	0.981	Human
embryo development ending in birth or egg hatching	GO:0009792	271	0.978	Worm
head development	GO:0060322	303	0.975
central nervous system development	GO:0007417	387	0.972
nucleic acid templated transcription	GO:0097659	181	0.963	Zebrafish Mouse
positive regulation of biological process	GO:0048518	253	0.955	Zebrafish Mouse
transcription dna templated	GO:0006351	181	0.955	Zebrafish Mouse
hemopoiesis	GO:0030097	183	0.948	Human Mouse
regulation of response to stimulus	GO:0048583	269	0.944
facial nerve morphogenesis	GO:0021610	1	0.935
morphogenesis of an epithelium	GO:0002009	333	0.933
regulation of transcription dna templated	GO:0006355	213	0.931	Zebrafish Mouse
skeletal system development	GO:0001501	181	0.929
organic cyclic compound metabolic process	GO:1901360	301	0.923	Zebrafish Mouse
rhombomere 5 development	GO:0021571	4	0.920
cellular component morphogenesis	GO:0032989	336	0.917
locomotion	GO:0040011	313	0.910
rhombomere 5 morphogenesis	GO:0021664	1	0.910
chordate embryonic development	GO:0043009	271	0.910
signal transduction	GO:0007165	455	0.900
nucleobase containing compound biosynthetic process	GO:0034654	205	0.898	Zebrafish Mouse
embryonic organ development	GO:0048568	381	0.898	Mouse
rna metabolic process	GO:0016070	219	0.896	Zebrafish Mouse
embryonic organ morphogenesis	GO:0048562	274	0.886	Mouse
facial nerve development	GO:0021561	3	0.872
hindbrain development	GO:0030902	91	0.863
nucleobase containing compound metabolic process	GO:0006139	274	0.853	Zebrafish Mouse
regulation of rna metabolic process	GO:0051252	224	0.852	Zebrafish Mouse
regulation of cell communication	GO:0010646	232	0.852
regulation of nitrogen compound metabolic process	GO:0051171	251	0.850	Zebrafish Mouse
nitrogen compound metabolic process	GO:0006807	319	0.838	Zebrafish Mouse
embryonic skeletal system development	GO:0048706	97	0.837
nucleic acid metabolic process	GO:0090304	244	0.835	Zebrafish Mouse
rna biosynthetic process	GO:0032774	181	0.832	Zebrafish Mouse
cellular biosynthetic process	GO:0044249	286	0.828	Zebrafish Mouse
cellular macromolecule biosynthetic process	GO:0034645	224	0.814	Zebrafish Mouse
cell morphogenesis	GO:0000902	289	0.803
transcription from rna polymerase ii promoter	GO:0006366	80	0.798	Mouse
regulation of metabolic process	GO:0019222	359	0.796	Zebrafish Mouse
transmembrane receptor protein tyrosine kinase signaling pathway	GO:0007169	42	0.789
establishment of localization	GO:0051234	244	0.786
regulation of neurogenesis	GO:0050767	87	0.780
single organism localization	GO:1902578	225	0.779
regulation of cellular amino acid metabolic process	GO:0006521	0	0.777
neural tube development	GO:0021915	62	0.774
anatomical structure arrangement	GO:0048532	2	0.774
regulation of signaling	GO:0023051	235	0.767
epithelial cell differentiation	GO:0030855	116	0.755
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.752	Zebrafish Mouse
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.751
eye development	GO:0001654	277	0.750
cellular nitrogen compound metabolic process	GO:0034641	290	0.747	Zebrafish Mouse
rhombomere morphogenesis	GO:0021593	17	0.739
regulation of biological quality	GO:0065008	263	0.733	Human
cellular component movement	GO:0006928	335	0.730
regulation of cell morphogenesis	GO:0022604	42	0.722
response to chemical	GO:0042221	320	0.717
cell morphogenesis involved in differentiation	GO:0000904	195	0.715
localization of cell	GO:0051674	244	0.694
organelle organization	GO:0006996	227	0.685
single organism transport	GO:0044765	206	0.684
stem cell development	GO:0048864	82	0.683
immune system development	GO:0002520	191	0.680	Human Mouse
dorsal ventral pattern formation	GO:0009953	125	0.676
cell projection organization	GO:0030030	284	0.676
axon guidance	GO:0007411	86	0.676
neuron projection guidance	GO:0097485	86	0.673
cellular protein metabolic process	GO:0044267	129	0.668
generation of neurons	GO:0048699	385	0.657
biosynthetic process	GO:0009058	294	0.655	Zebrafish Mouse
cell migration	GO:0016477	237	0.654
embryonic skeletal system morphogenesis	GO:0048704	93	0.647
positive regulation of metabolic process	GO:0009893	108	0.647	Zebrafish Mouse
epidermis development	GO:0008544	48	0.645
positive regulation of macromolecule metabolic process	GO:0010604	93	0.643	Zebrafish Mouse
camera type eye development	GO:0043010	222	0.642
regulation of cell development	GO:0060284	100	0.637
myeloid cell differentiation	GO:0030099	86	0.633	Human
positive regulation of cellular process	GO:0048522	201	0.630	Zebrafish Mouse
vasculature development	GO:0001944	278	0.625
regulation of primary metabolic process	GO:0080090	311	0.620	Zebrafish Mouse
aromatic compound biosynthetic process	GO:0019438	217	0.615	Zebrafish Mouse
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.613
taxis	GO:0042330	109	0.612
rhombomere development	GO:0021546	19	0.606
inner ear development	GO:0048839	126	0.596	Mouse
transport	GO:0006810	220	0.595
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.591	Zebrafish Mouse
heart development	GO:0007507	313	0.585
regulation of signal transduction	GO:0009966	225	0.585
regulation of anatomical structure morphogenesis	GO:0022603	130	0.578
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.572	Zebrafish Mouse
cellular amine metabolic process	GO:0044106	2	0.570
cellular aromatic compound metabolic process	GO:0006725	295	0.567	Zebrafish Mouse
cell proliferation	GO:0008283	80	0.562
neuron differentiation	GO:0030182	353	0.560
anterior posterior pattern specification	GO:0009952	152	0.559
brain development	GO:0007420	293	0.550
sensory organ development	GO:0007423	393	0.547	Mouse
cell adhesion	GO:0007155	40	0.545
regulation of peptidyl tyrosine phosphorylation	GO:0050730	1	0.544
single organism organelle organization	GO:1902589	199	0.542
digestive system development	GO:0055123	289	0.536
motor neuron axon guidance	GO:0008045	23	0.530
regulation of cell shape	GO:0008360	1	0.529
regulation of macromolecule metabolic process	GO:0060255	317	0.526	Zebrafish Mouse
regulation of cellular amine metabolic process	GO:0033238	0	0.520
nucleocytoplasmic transport	GO:0006913	4	0.517
preganglionic parasympathetic nervous system development	GO:0021783	6	0.509
intracellular signal transduction	GO:0035556	85	0.505
connective tissue development	GO:0061448	99	0.504
positive regulation of neuron apoptotic process	GO:0043525	1	0.499
negative regulation of signaling	GO:0023057	96	0.493
muscle cell differentiation	GO:0042692	139	0.492
regulation of nucleic acid templated transcription	GO:1903506	213	0.484	Zebrafish Mouse
regulation of macromolecule biosynthetic process	GO:0010556	225	0.480	Zebrafish Mouse
amine metabolic process	GO:0009308	2	0.476
regulation of cellular metabolic process	GO:0031323	320	0.476	Zebrafish Mouse
positive regulation of protein metabolic process	GO:0051247	23	0.475
cartilage development	GO:0051216	96	0.472
skeletal system morphogenesis	GO:0048705	102	0.468
regulation of multicellular organismal process	GO:0051239	277	0.468	Human
cellular ketone metabolic process	GO:0042180	11	0.464
macromolecule biosynthetic process	GO:0009059	227	0.460	Zebrafish Mouse
eye morphogenesis	GO:0048592	144	0.458
actin filament based process	GO:0030029	64	0.454
establishment or maintenance of apical basal cell polarity	GO:0035088	12	0.450
regulation of cellular biosynthetic process	GO:0031326	245	0.448	Zebrafish Mouse
cranial nerve development	GO:0021545	42	0.441
blood vessel development	GO:0001568	246	0.440
response to drug	GO:0042493	3	0.437
cellular macromolecule metabolic process	GO:0044260	391	0.431	Zebrafish Mouse
diencephalon development	GO:0021536	58	0.430
epithelial tube morphogenesis	GO:0060562	148	0.425
reproduction	GO:0000003	40	0.422
ossification	GO:0001503	23	0.414
larval development	GO:0002164	2	0.409
regionalization	GO:0003002	274	0.408
positive regulation of signaling	GO:0023056	56	0.406
phosphorus metabolic process	GO:0006793	109	0.403
cell motility	GO:0048870	244	0.396
somitogenesis	GO:0001756	87	0.391
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.385
regulation of cellular ketone metabolic process	GO:0010565	7	0.382
negative regulation of cellular process	GO:0048523	283	0.379	Human
protein complex subunit organization	GO:0071822	46	0.376
macromolecular complex subunit organization	GO:0043933	74	0.375
immune system process	GO:0002376	241	0.375	Human Mouse
myelination of posterior lateral line nerve axons	GO:0048932	5	0.374
positive regulation of cell differentiation	GO:0045597	30	0.372
regulation of developmental process	GO:0050793	247	0.370	Human
regulation of rna biosynthetic process	GO:2001141	213	0.368	Zebrafish Mouse
positive regulation of cellular amino acid metabolic process	GO:0045764	0	0.368
central nervous system neuron differentiation	GO:0021953	74	0.364
regulation of biosynthetic process	GO:0009889	250	0.364	Zebrafish Mouse
gene expression	GO:0010467	252	0.353	Zebrafish Mouse
branchiomotor neuron axon guidance	GO:0021785	1	0.351
regulation of localization	GO:0032879	104	0.349
cell cell signaling	GO:0007267	52	0.348
positive regulation of response to stimulus	GO:0048584	80	0.344
negative regulation of biological process	GO:0048519	304	0.343	Human
embryonic pattern specification	GO:0009880	44	0.339
muscle structure development	GO:0061061	196	0.335
cell projection morphogenesis	GO:0048858	244	0.334
single organism cell adhesion	GO:0098602	29	0.333
cell migration in hindbrain	GO:0021535	7	0.330
regulation of system process	GO:0044057	40	0.328
protein modification process	GO:0036211	100	0.327
embryonic viscerocranium morphogenesis	GO:0048703	52	0.326
biological adhesion	GO:0022610	40	0.325
axon development	GO:0061564	166	0.323
regulation of jak stat cascade	GO:0046425	3	0.322
angiogenesis	GO:0001525	158	0.321
regulation of immune system process	GO:0002682	34	0.321	Human
single organism metabolic process	GO:0044710	217	0.317
digestive tract development	GO:0048565	265	0.315
single organismal cell cell adhesion	GO:0016337	29	0.313
lymphocyte activation	GO:0046649	10	0.308	Mouse
behavior	GO:0007610	74	0.306
regulation of catalytic activity	GO:0050790	55	0.304
multicellular organism growth	GO:0035264	4	0.303
gland development	GO:0048732	143	0.303	Mouse
retina development in camera type eye	GO:0060041	146	0.302
regulation of molecular function	GO:0065009	70	0.298
morphogenesis of embryonic epithelium	GO:0016331	30	0.297
regulation of cell death	GO:0010941	103	0.294
macromolecule modification	GO:0043412	111	0.294
chemotaxis	GO:0006935	104	0.292
cellular protein modification process	GO:0006464	100	0.292
response to wounding	GO:0009611	116	0.288
endocrine system development	GO:0035270	65	0.287
sympathetic nervous system development	GO:0048485	3	0.285
inner ear morphogenesis	GO:0042472	63	0.283	Mouse
spinal cord development	GO:0021510	46	0.282
ear morphogenesis	GO:0042471	64	0.278	Mouse
cellular amino acid metabolic process	GO:0006520	7	0.277
immune response	GO:0006955	28	0.276
striated muscle cell differentiation	GO:0051146	129	0.272
myelination of lateral line nerve axons	GO:0048897	5	0.271
blood vessel morphogenesis	GO:0048514	216	0.269
negative regulation of signal transduction	GO:0009968	94	0.268
response to organic substance	GO:0010033	153	0.268
cell fate commitment	GO:0045165	99	0.265
ventral spinal cord interneuron specification	GO:0021521	3	0.265
post anal tail morphogenesis	GO:0036342	19	0.264
organic substance biosynthetic process	GO:1901576	289	0.258	Zebrafish Mouse
nuclear export	GO:0051168	1	0.257
autonomic nervous system development	GO:0048483	19	0.255
cell part morphogenesis	GO:0032990	246	0.253
neuron migration	GO:0001764	22	0.253
neuroblast proliferation	GO:0007405	2	0.252
cellular component assembly	GO:0022607	170	0.252
phosphorylation	GO:0016310	69	0.251
death	GO:0016265	121	0.245
cell cycle process	GO:0022402	53	0.244
cytoskeleton organization	GO:0007010	96	0.244
neuron projection morphogenesis	GO:0048812	161	0.242
negative regulation of response to stimulus	GO:0048585	104	0.240
protein metabolic process	GO:0019538	183	0.240
cellular process involved in reproduction in multicellular organism	GO:0022412	28	0.236
regulation of transferase activity	GO:0051338	16	0.234
muscle tissue development	GO:0060537	110	0.233
renal system development	GO:0072001	94	0.231
forebrain development	GO:0030900	96	0.230
positive regulation of cell communication	GO:0010647	56	0.230
mesoderm development	GO:0007498	88	0.230
neuron development	GO:0048666	262	0.229
negative regulation of multicellular organismal process	GO:0051241	69	0.229	Human
ear development	GO:0043583	127	0.227	Mouse
regulation of protein phosphorylation	GO:0001932	18	0.226
organic acid metabolic process	GO:0006082	31	0.225
regulation of intracellular signal transduction	GO:1902531	57	0.224
rhombomere formation	GO:0021594	12	0.223
columnar cuboidal epithelial cell differentiation	GO:0002065	38	0.222
venous blood vessel development	GO:0060841	9	0.222
negative regulation of cell communication	GO:0010648	96	0.222
tube morphogenesis	GO:0035239	349	0.222
axonogenesis	GO:0007409	152	0.221
convergent extension	GO:0060026	118	0.221
response to external stimulus	GO:0009605	264	0.220
heart process	GO:0003015	71	0.219
posterior lateral line nerve glial cell morphogenesis involved in differentiation	GO:0048942	5	0.219
cell death	GO:0008219	121	0.219
cell fate specification	GO:0001708	68	0.215
positive regulation of notch signaling pathway	GO:0045747	3	0.215
melanocyte differentiation	GO:0030318	26	0.211
skin development	GO:0043588	54	0.208
formation of primary germ layer	GO:0001704	62	0.207
retinal ganglion cell axon guidance	GO:0031290	35	0.205
positive regulation of developmental process	GO:0051094	50	0.205
positive regulation of signal transduction	GO:0009967	56	0.204
nuclear transport	GO:0051169	4	0.204
positive regulation of peptidyl tyrosine phosphorylation	GO:0050731	1	0.202
adrenal gland development	GO:0030325	10	0.198
regulation of cellular component organization	GO:0051128	86	0.198
regulation of cell proliferation	GO:0042127	37	0.195
system process	GO:0003008	185	0.194
nerve development	GO:0021675	45	0.194
positive regulation of rna biosynthetic process	GO:1902680	57	0.192	Zebrafish Mouse
regulation of biomineral tissue development	GO:0070167	2	0.188
ovulation cycle	GO:0042698	2	0.186
regulation of gene expression	GO:0010468	265	0.186	Zebrafish Mouse
leukocyte differentiation	GO:0002521	25	0.185	Mouse
regulation of endopeptidase activity	GO:0052548	23	0.185
negative regulation of neuron differentiation	GO:0045665	10	0.184
positive regulation of neuron death	GO:1901216	1	0.183
positive regulation of cellular amine metabolic process	GO:0033240	0	0.182
dendrite guidance	GO:0070983	0	0.181
response to stress	GO:0006950	263	0.181
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.181
positive regulation of gene expression	GO:0010628	71	0.180	Zebrafish Mouse
pronephros development	GO:0048793	69	0.179
organonitrogen compound metabolic process	GO:1901564	74	0.179
regulation of neuron differentiation	GO:0045664	56	0.177
mesodermal cell differentiation	GO:0048333	21	0.177
skeletal muscle tissue development	GO:0007519	67	0.174
muscle organ development	GO:0007517	101	0.173
hair cell differentiation	GO:0035315	32	0.173
establishment of localization in cell	GO:0051649	77	0.170
sprouting angiogenesis	GO:0002040	53	0.168
circulatory system process	GO:0003013	87	0.167
positive regulation of molecular function	GO:0044093	33	0.167
posterior lateral line nerve glial cell differentiation	GO:0048931	5	0.167
regulation of protein modification process	GO:0031399	29	0.165
positive regulation of cell activation	GO:0050867	1	0.165
neural crest cell differentiation	GO:0014033	72	0.162
phosphate containing compound metabolic process	GO:0006796	108	0.160
regulation of neural precursor cell proliferation	GO:2000177	3	0.159
urogenital system development	GO:0001655	97	0.158
cell cycle	GO:0007049	93	0.157
regulation of cell motility	GO:2000145	46	0.154
sensory organ morphogenesis	GO:0090596	200	0.154	Mouse
photoreceptor cell fate specification	GO:0043704	1	0.154
apoptotic process	GO:0006915	116	0.153
regulation of cell morphogenesis involved in differentiation	GO:0010769	38	0.150
otic vesicle development	GO:0071599	42	0.150
oxoacid metabolic process	GO:0043436	31	0.150
regulation of neuron projection development	GO:0010975	40	0.149
regulation of kinase activity	GO:0043549	15	0.144
regulation of bone mineralization	GO:0030500	2	0.143
biomineral tissue development	GO:0031214	13	0.142
regulation of nervous system development	GO:0051960	90	0.142
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.142	Mouse
regulation of establishment of protein localization	GO:0070201	4	0.141
regulation of axonogenesis	GO:0050770	32	0.140
otic placode formation	GO:0043049	23	0.140
cellular response to organic substance	GO:0071310	105	0.139
rhombomere boundary formation	GO:0021654	10	0.138
regulation of locomotion	GO:0040012	55	0.137
regulation of cell activation	GO:0050865	1	0.135
otic vesicle formation	GO:0030916	27	0.134
forebrain neuron differentiation	GO:0021879	14	0.133
regulation of stem cell differentiation	GO:2000736	4	0.133
microtubule based process	GO:0007017	60	0.133
transmission of nerve impulse	GO:0019226	19	0.133
cellular localization	GO:0051641	97	0.133
establishment of organelle localization	GO:0051656	45	0.133
positive regulation of immune response	GO:0050778	11	0.133
pronephric glomerulus development	GO:0039021	13	0.132
camera type eye morphogenesis	GO:0048593	108	0.129
skeletal muscle organ development	GO:0060538	78	0.128
regulation of protein metabolic process	GO:0051246	56	0.128
regulation of cellular component movement	GO:0051270	55	0.126
positive regulation of immune effector process	GO:0002699	3	0.125
positive regulation of biosynthetic process	GO:0009891	68	0.124	Zebrafish Mouse
mitotic cell cycle process	GO:1903047	48	0.124
notch signaling pathway	GO:0007219	35	0.124
gastrulation	GO:0007369	208	0.124
negative regulation of protein kinase activity	GO:0006469	4	0.123
glomerular epithelial cell fate commitment	GO:0072314	4	0.123
pronephric nephron development	GO:0039019	14	0.121
midbrain hindbrain boundary development	GO:0030917	23	0.121
tissue regeneration	GO:0042246	74	0.121
developmental growth involved in morphogenesis	GO:0060560	86	0.120
cellular component biogenesis	GO:0044085	178	0.120
neural crest cell migration	GO:0001755	42	0.118
reproductive process	GO:0022414	40	0.117
positive regulation of immune system process	GO:0002684	17	0.117
positive regulation of rna metabolic process	GO:0051254	59	0.117	Zebrafish Mouse
leukocyte chemotaxis	GO:0030595	12	0.116
apoptotic process involved in morphogenesis	GO:0060561	2	0.116
production of molecular mediator of immune response	GO:0002440	2	0.115
blood vessel endothelial cell migration	GO:0043534	18	0.114
carboxylic acid metabolic process	GO:0019752	22	0.114
regulation of binding	GO:0051098	3	0.112
kidney development	GO:0001822	92	0.112
protein phosphorylation	GO:0006468	47	0.111
otic vesicle morphogenesis	GO:0071600	34	0.110
pronephric duct development	GO:0039022	13	0.110
germ cell development	GO:0007281	22	0.110
cellular response to organic cyclic compound	GO:0071407	38	0.109
retina morphogenesis in camera type eye	GO:0060042	79	0.108
negative regulation of axon guidance	GO:1902668	1	0.108
protein localization to nucleus	GO:0034504	3	0.107
segmentation	GO:0035282	97	0.106	Mouse
heart jogging	GO:0003146	40	0.106
aging	GO:0007568	2	0.105
establishment of cell polarity	GO:0030010	18	0.105
regulation of axon guidance	GO:1902667	8	0.101
regulation of apoptotic process	GO:0042981	98	0.101
rhombomere 4 development	GO:0021570	5	0.101
forebrain anterior posterior pattern specification	GO:0021797	3	0.100
response to hormone	GO:0009725	48	0.100
regulation of phosphorus metabolic process	GO:0051174	43	0.100
regulation of cytokine production	GO:0001817	3	0.099
pigment cell differentiation	GO:0050931	38	0.098
lymph vessel morphogenesis	GO:0036303	25	0.098
erk1 and erk2 cascade	GO:0070371	4	0.096
neural tube formation	GO:0001841	16	0.095
mesenchymal cell differentiation	GO:0048762	87	0.093
heterocycle metabolic process	GO:0046483	290	0.093	Zebrafish Mouse
striated muscle tissue development	GO:0014706	110	0.093
sexual reproduction	GO:0019953	36	0.091
cilium assembly	GO:0042384	58	0.091
female sex differentiation	GO:0046660	4	0.091
blood circulation	GO:0008015	87	0.091
programmed cell death	GO:0012501	119	0.091
apoptotic process involved in development	GO:1902742	2	0.091
regulation of erk1 and erk2 cascade	GO:0070372	4	0.090
negative regulation of sequence specific dna binding transcription factor activity	GO:0043433	2	0.090
regulation of cell projection organization	GO:0031344	44	0.089
establishment or maintenance of cell polarity	GO:0007163	29	0.088
establishment of spindle localization	GO:0051293	12	0.087
cytokine mediated signaling pathway	GO:0019221	7	0.087
rostrocaudal neural tube patterning	GO:0021903	29	0.087
wound healing	GO:0042060	90	0.087
negative regulation of axon extension involved in axon guidance	GO:0048843	1	0.087
hard palate development	GO:0060022	4	0.086
positive regulation of response to external stimulus	GO:0032103	9	0.085
ameboidal type cell migration	GO:0001667	143	0.085
positive regulation of synaptic growth at neuromuscular junction	GO:0045887	1	0.085
regulation of protein kinase activity	GO:0045859	15	0.084
heart morphogenesis	GO:0003007	156	0.084
regulation of neuronal synaptic plasticity	GO:0048168	1	0.084
organic cyclic compound biosynthetic process	GO:1901362	223	0.083	Zebrafish Mouse
actin cytoskeleton organization	GO:0030036	63	0.083
protein secretion	GO:0009306	1	0.083
lateral line nerve glial cell morphogenesis involved in differentiation	GO:0048938	5	0.083
regulation of stem cell proliferation	GO:0072091	2	0.082
regulation of immune response	GO:0050776	14	0.080
neuroepithelial cell differentiation	GO:0060563	26	0.080
stem cell proliferation	GO:0072089	4	0.080
positive regulation of cell morphogenesis involved in differentiation	GO:0010770	6	0.080
negative regulation of map kinase activity	GO:0043407	2	0.079
leukocyte proliferation	GO:0070661	1	0.079
limbic system development	GO:0021761	16	0.079
positive regulation of oocyte development	GO:0060282	1	0.078
spindle localization	GO:0051653	12	0.078
peptidyl tyrosine modification	GO:0018212	5	0.078
multicellular organismal signaling	GO:0035637	22	0.076
endoderm formation	GO:0001706	29	0.076
developmental programmed cell death	GO:0010623	4	0.075
bone morphogenesis	GO:0060349	11	0.074
protein localization	GO:0008104	40	0.074
digestive tract morphogenesis	GO:0048546	231	0.074
mesoderm formation	GO:0001707	43	0.074
cellular response to growth factor stimulus	GO:0071363	39	0.074
embryonic heart tube development	GO:0035050	133	0.073
gastrulation with mouth forming second	GO:0001702	44	0.072
regeneration	GO:0031099	91	0.072
action potential	GO:0001508	19	0.071
neuronal action potential	GO:0019228	18	0.071
adaptive immune response	GO:0002250	5	0.070
cranial nerve morphogenesis	GO:0021602	15	0.070
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.069	Zebrafish Mouse
regulation of cellular protein metabolic process	GO:0032268	52	0.069
negative regulation of neutrophil chemotaxis	GO:0090024	3	0.068
positive regulation of cellular protein metabolic process	GO:0032270	22	0.068
heterocycle biosynthetic process	GO:0018130	215	0.068	Zebrafish Mouse
signal transduction by phosphorylation	GO:0023014	18	0.067
cell junction organization	GO:0034330	11	0.067
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains	GO:0002460	4	0.066
positive regulation of cell matrix adhesion	GO:0001954	1	0.066
positive regulation of cellular component biogenesis	GO:0044089	3	0.066
microtubule cytoskeleton organization	GO:0000226	33	0.065
regulation of erythrocyte differentiation	GO:0045646	2	0.065	Human
cell projection assembly	GO:0030031	64	0.064
positive regulation of map kinase activity	GO:0043406	3	0.064
posterior lateral line nerve glial cell development	GO:0048941	5	0.064
stem cell differentiation	GO:0048863	117	0.063
myeloid leukocyte differentiation	GO:0002573	15	0.063
positive regulation of myeloid cell differentiation	GO:0045639	2	0.063
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.063	Zebrafish Mouse
negative regulation of macromolecule metabolic process	GO:0010605	76	0.063
positive regulation of protein complex assembly	GO:0031334	2	0.063
histone deacetylation	GO:0016575	2	0.062
positive regulation of cell death	GO:0010942	29	0.061
synaptic transmission	GO:0007268	35	0.061
habenula development	GO:0021986	9	0.061
organelle assembly	GO:0070925	110	0.061
neuron projection development	GO:0031175	180	0.060
peripheral nervous system development	GO:0007422	55	0.060
positive regulation of cellular metabolic process	GO:0031325	94	0.060	Zebrafish Mouse
cell matrix adhesion	GO:0007160	4	0.060
inositol lipid mediated signaling	GO:0048017	2	0.060
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.060
myelination	GO:0042552	18	0.059
positive chemotaxis	GO:0050918	5	0.059
developmental growth	GO:0048589	166	0.059
negative regulation of kinase activity	GO:0033673	4	0.058
cognition	GO:0050890	1	0.058
dendrite development	GO:0016358	9	0.057
multicellular organismal reproductive process	GO:0048609	35	0.057
regulation of dendrite development	GO:0050773	3	0.057
embryonic heart tube morphogenesis	GO:0003143	108	0.056
positive regulation of transport	GO:0051050	2	0.056
nephron tubule morphogenesis	GO:0072078	1	0.056
developmental maturation	GO:0021700	34	0.056
regulation of axon extension	GO:0030516	24	0.055
chromosome organization	GO:0051276	31	0.055
response to endogenous stimulus	GO:0009719	83	0.055
negative regulation of cell death	GO:0060548	60	0.055
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.054	Mouse
primary neural tube formation	GO:0014020	1	0.054
negative regulation of neurogenesis	GO:0050768	20	0.054
negative regulation of cytokine production	GO:0001818	1	0.054
developmental process involved in reproduction	GO:0003006	27	0.054
phosphatidylinositol 3 kinase signaling	GO:0014065	2	0.053
positive regulation of transcription dna templated	GO:0045893	57	0.053	Zebrafish Mouse
regulation of myeloid cell differentiation	GO:0045637	8	0.053	Human
positive regulation of programmed cell death	GO:0043068	29	0.053
cell substrate adhesion	GO:0031589	4	0.053
positive regulation of cell adhesion	GO:0045785	1	0.052
oocyte development	GO:0048599	14	0.052
growth	GO:0040007	174	0.052
phagocytosis	GO:0006909	3	0.052
regulation of cell migration	GO:0030334	40	0.052
epidermal cell differentiation	GO:0009913	36	0.052
negative regulation of metabolic process	GO:0009892	86	0.052
neural crest cell development	GO:0014032	62	0.051

mafba disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
charcot marie tooth disease type 4	DOID:0050541	0.102
neuromuscular disease	DOID:440	0.102
disease of anatomical entity	DOID:7	0.102
charcot marie tooth disease	DOID:10595	0.102
nervous system disease	DOID:863	0.102
neuropathy	DOID:870	0.102

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