Danio rerio

0 known processes

rfx1b

regulatory factor X, 1b (influences HLA class II expression)

(Aliases: im:7137369)

rfx1b biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
regulation of nucleobase containing compound metabolic processGO:00192192500.137
rna biosynthetic processGO:00327741810.128
regulation of macromolecule metabolic processGO:00602553170.125
regulation of cellular biosynthetic processGO:00313262450.115
transcription dna templatedGO:00063511810.112
cellular biosynthetic processGO:00442492860.111
nucleobase containing compound biosynthetic processGO:00346542050.105
regulation of nucleic acid templated transcriptionGO:19035062130.094
nitrogen compound metabolic processGO:00068073190.094
organic cyclic compound metabolic processGO:19013603010.093
cellular nitrogen compound metabolic processGO:00346412900.091
cellular macromolecule biosynthetic processGO:00346452240.088
cellular aromatic compound metabolic processGO:00067252950.087
regulation of metabolic processGO:00192223590.085
regulation of biosynthetic processGO:00098892500.085
regulation of cellular metabolic processGO:00313233200.084
larval developmentGO:000216420.084
nucleobase containing compound metabolic processGO:00061392740.082
nucleic acid metabolic processGO:00903042440.081
cellular macromolecule metabolic processGO:00442603910.076
regulation of cellular macromolecule biosynthetic processGO:20001122220.073
rna metabolic processGO:00160702190.072
agingGO:000756820.070
regulation of nitrogen compound metabolic processGO:00511712510.070
negative regulation of biological processGO:00485193040.069
regulation of gene expressionGO:00104682650.069
stem cell proliferationGO:007208940.068
embryonic organ developmentGO:00485683810.068
nuclear transportGO:005116940.067
positive regulation of biological processGO:00485182530.064
organic substance biosynthetic processGO:19015762890.063
organic cyclic compound biosynthetic processGO:19013622230.062
negative regulation of cellular processGO:00485232830.061
regulation of transcription dna templatedGO:00063552130.060
maintenance of locationGO:005123540.059
regulation of rna biosynthetic processGO:20011412130.059
aromatic compound biosynthetic processGO:00194382170.059
biosynthetic processGO:00090582940.059
regulation of multicellular organism growthGO:004001440.058
heterocycle biosynthetic processGO:00181302150.057
macromolecule biosynthetic processGO:00090592270.056
signal transductionGO:00071654550.055
regulation of rna metabolic processGO:00512522240.054
tube morphogenesisGO:00352393490.051
ubiquitin dependent protein catabolic processGO:000651130.051
nucleocytoplasmic transportGO:000691340.050
regulation of primary metabolic processGO:00800903110.049
heterocycle metabolic processGO:00464832900.048
cellular nitrogen compound biosynthetic processGO:00442712180.047
regulation of macromolecule biosynthetic processGO:00105562250.046
cell surface receptor signaling pathwayGO:00071663250.046
modification dependent protein catabolic processGO:001994130.046
embryonic organ morphogenesisGO:00485622740.044
nucleic acid templated transcriptionGO:00976591810.044
regulation of stem cell proliferationGO:007209120.044
regulation of signal transductionGO:00099662250.044
lipid storageGO:001991510.043
multicellular organism growthGO:003526440.042
cellular amine metabolic processGO:004410620.042
positive regulation of transportGO:005105020.041
spindle assemblyGO:005122520.041
organelle organizationGO:00069962270.041
centrosome duplicationGO:005129810.040
regulation of circadian rhythmGO:004275240.040
negative regulation of protein phosphorylationGO:000193340.039
amine metabolic processGO:000930820.038
protein localization to nucleusGO:003450430.038
positive regulation of catabolic processGO:000989640.038
modification dependent macromolecule catabolic processGO:004363230.037
single organism metabolic processGO:00447102170.037
meiotic nuclear divisionGO:000712640.037
nuclear exportGO:005116810.036
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.035
single organism nuclear importGO:190259330.035
digestive tract developmentGO:00485652650.034
regulation of protein complex assemblyGO:004325430.034
meiotic chromosome segregationGO:004513230.034
positive regulation of cellular catabolic processGO:003133130.034
gene expressionGO:00104672520.034
regulation of cell communicationGO:00106462320.034
regulation of mrna splicing via spliceosomeGO:004802430.034
multi organism processGO:00517041340.034
meiotic cell cycle processGO:190304630.034
cellular component morphogenesisGO:00329893360.034
negative regulation of response to stimulusGO:00485851040.034
protein metabolic processGO:00195381830.033
morphogenesis of an epitheliumGO:00020093330.033
apoptotic processGO:00069151160.033
cell cycle g1 s phase transitionGO:004484310.032
positive regulation of nitrogen compound metabolic processGO:0051173690.031
digestive system developmentGO:00551232890.031
generation of neuronsGO:00486993850.031
regulation of establishment of protein localizationGO:007020140.031
regulation of developmental processGO:00507932470.030
neuron developmentGO:00486662620.030
g1 s transition of mitotic cell cycleGO:000008210.030
regulation of signalingGO:00230512350.029
stem cell maintenanceGO:001982740.029
sensory organ developmentGO:00074233930.029
deathGO:00162651210.029
embryo development ending in birth or egg hatchingGO:00097922710.028
regulation of cellular amine metabolic processGO:003323800.028
extrinsic apoptotic signaling pathwayGO:009719130.028
cellular amino acid metabolic processGO:000652070.028
cell morphogenesisGO:00009022890.028
small molecule metabolic processGO:0044281770.028
dna templated transcription elongationGO:000635430.028
single organism organelle organizationGO:19025891990.028
positive regulation of map kinase activityGO:004340630.028
regulation of protein transportGO:005122330.028
programmed cell deathGO:00125011190.028
primary neural tube formationGO:001402010.027
regulation of cytoplasmic transportGO:190364940.027
positive regulation of cellular component biogenesisGO:004408930.027
regulation of multicellular organismal processGO:00512392770.027
positive regulation of cellular processGO:00485222010.027
establishment of protein localization to organelleGO:007259440.026
regulation of cell shapeGO:000836010.026
positive regulation of gene expressionGO:0010628710.026
regulation of protein modification by small protein conjugation or removalGO:190332030.026
regionalizationGO:00030022740.026
regulation of alternative mrna splicing via spliceosomeGO:000038110.026
negative regulation of macromolecule metabolic processGO:0010605760.026
regulation of cellular amino acid metabolic processGO:000652100.026
cellular component disassemblyGO:002241110.026
regulation of nucleocytoplasmic transportGO:004682220.026
positive regulation of gtp catabolic processGO:003312610.025
response to chemicalGO:00422213200.025
chemosensory behaviorGO:000763510.025
phagocytosisGO:000690930.025
cellular protein modification processGO:00064641000.024
cell projection organizationGO:00300302840.024
cellular protein metabolic processGO:00442671290.024
protein modification processGO:00362111000.024
chordate embryonic developmentGO:00430092710.024
cell part morphogenesisGO:00329902460.024
macromolecule modificationGO:00434121110.024
protein import into nucleusGO:000660630.024
positive regulation of protein complex assemblyGO:003133420.024
negative regulation of kinase activityGO:003367340.024
positive regulation of biosynthetic processGO:0009891680.024
oxoacid metabolic processGO:0043436310.024
cell matrix adhesionGO:000716040.024
carboxylic acid metabolic processGO:0019752220.024
cell substrate adhesionGO:003158940.023
regulation of programmed cell deathGO:00430671010.023
development of primary female sexual characteristicsGO:004654540.023
transcription from rna polymerase ii promoterGO:0006366800.023
protein dephosphorylationGO:000647030.023
response to stressGO:00069502630.023
regulation of peptidyl tyrosine phosphorylationGO:005073010.023
cell deathGO:00082191210.023
female sex differentiationGO:004666040.023
regulation of mrna processingGO:005068430.023
regulation of cellular ketone metabolic processGO:001056570.023
regulation of transcription from rna polymerase ii promoterGO:00063571140.023
cell cycleGO:0007049930.023
central nervous system developmentGO:00074173870.022
tissue remodelingGO:004877140.022
regulation of bindingGO:005109830.022
organonitrogen compound metabolic processGO:1901564740.022
meiosis iGO:000712710.022
guanosine containing compound catabolic processGO:190106920.022
immune system developmentGO:00025201910.022
neuron differentiationGO:00301823530.022
proteasomal protein catabolic processGO:001049820.022
positive regulation of metabolic processGO:00098931080.022
gastrulationGO:00073692080.022
regulation of purine nucleotide catabolic processGO:003312120.022
phosphate containing compound metabolic processGO:00067961080.022
erk1 and erk2 cascadeGO:007037140.022
regulation of nucleoside metabolic processGO:000911820.022
cytokinesisGO:000091030.022
positive regulation of macromolecule biosynthetic processGO:0010557590.021
gtp metabolic processGO:004603940.021
regulation of reproductive processGO:200024140.021
digestive tract morphogenesisGO:00485462310.021
cellular ketone metabolic processGO:0042180110.021
negative regulation of cellular metabolic processGO:0031324770.021
heart developmentGO:00075073130.021
gtp catabolic processGO:000618420.021
regulation of biological qualityGO:00650082630.021
protein importGO:001703830.021
regulation of erk1 and erk2 cascadeGO:007037240.021
stem cell fate commitmentGO:004886510.021
lamellipodium organizationGO:009758110.021
positive regulation of stress activated mapk cascadeGO:003287430.021
regulation of intracellular protein transportGO:003315730.021
tube closureGO:006060610.021
regulation of protein catabolic processGO:004217610.021
cellular component assemblyGO:00226071700.021
epithelial tube morphogenesisGO:00605621480.021
golgi vesicle transportGO:004819330.020
cell projection morphogenesisGO:00488582440.020
nuclear importGO:005117030.020
mitotic cell cycleGO:0000278640.020
enzyme linked receptor protein signaling pathwayGO:00071671060.020
guanosine containing compound metabolic processGO:190106840.020
regulation of protein targetingGO:190353320.020
negative regulation of nitrogen compound metabolic processGO:0051172590.020
cellular protein catabolic processGO:004425740.020
regulation of cell deathGO:00109411030.020
negative regulation of biosynthetic processGO:0009890550.020
protein targeting to nucleusGO:004474430.020
negative regulation of protein kinase activityGO:000646940.020
positive regulation of transcription dna templatedGO:0045893570.020
positive regulation of canonical wnt signaling pathwayGO:009026340.020
alpha amino acid metabolic processGO:190160530.020
b cell activationGO:004211320.020
proteolysis involved in cellular protein catabolic processGO:005160330.020
organic acid metabolic processGO:0006082310.020
growthGO:00400071740.020
cellular component biogenesisGO:00440851780.019
mitotic dna integrity checkpointGO:004477440.019
cellular modified amino acid metabolic processGO:000657530.019
regulation of transcription elongation from rna polymerase ii promoterGO:003424330.019
regulation of epithelial cell proliferationGO:005067830.019
positive regulation of jnk cascadeGO:004633030.019
positive regulation of cell cycleGO:004578730.019
positive regulation of gtpase activityGO:004354710.019
regulation of cell activationGO:005086510.019
regulation of meiotic cell cycleGO:005144510.019
cellular response to organic substanceGO:00713101050.019
negative regulation of neural precursor cell proliferationGO:200017810.019
internal protein amino acid acetylationGO:000647520.019
pharyngeal muscle developmentGO:004328240.019
positive regulation of purine nucleotide catabolic processGO:003312310.019
positive regulation of notch signaling pathwayGO:004574730.019
regulation of response to stimulusGO:00485832690.019
locomotor rhythmGO:004547530.019
cellular response to extracellular stimulusGO:003166820.019
response to vitaminGO:003327330.019
ribonucleoside monophosphate catabolic processGO:000915840.019
regulation of nucleotide catabolic processGO:003081120.018
positive regulation of nucleotide catabolic processGO:003081310.018
regulation of cytokine productionGO:000181730.018
head developmentGO:00603223030.018
regulation of dna replicationGO:000627530.018
positive regulation of secretionGO:005104710.018
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.018
female gonad developmentGO:000858540.018
establishment of localizationGO:00512342440.018
regulation of stem cell differentiationGO:200073640.018
lamellipodium assemblyGO:003003210.018
protein polymerizationGO:005125840.018
positive regulation of nucleic acid templated transcriptionGO:1903508570.018
positive regulation of nucleobase containing compound metabolic processGO:0045935690.018
regulation of synapse assemblyGO:005196330.018
single organism membrane fusionGO:004480120.018
double strand break repairGO:000630230.018
negative regulation of ras protein signal transductionGO:004658010.017
phosphorus metabolic processGO:00067931090.017
macromolecular complex disassemblyGO:003298410.017
centrosome organizationGO:005129710.017
protein acetylationGO:000647320.017
regulation of protein complex disassemblyGO:004324410.017
g2 dna damage checkpointGO:003157230.017
compound eye developmentGO:004874920.017
neural tube developmentGO:0021915620.017
positive regulation of cellular amine metabolic processGO:003324000.017
cellular response to topologically incorrect proteinGO:003596720.017
male meiosisGO:000714020.017
positive regulation of nucleoside metabolic processGO:004597910.017
regulation of anatomical structure morphogenesisGO:00226031300.017
regulation of protein ubiquitinationGO:003139630.017
mrna export from nucleusGO:000640610.017
regulation of dna templated transcription elongationGO:003278430.017
positive regulation of cytoskeleton organizationGO:005149530.017
negative regulation of dna metabolic processGO:005105340.017
alternative mrna splicing via spliceosomeGO:000038010.017
mitotic cell cycle processGO:1903047480.017
negative regulation of protein complex assemblyGO:003133310.017
somatic stem cell maintenanceGO:003501910.016
transportGO:00068102200.016
regulation of dna recombinationGO:000001820.016
regulation of protein import into nucleusGO:004230620.016
protein acylationGO:004354330.016
regulation of cell matrix adhesionGO:000195210.016
regulation of extrinsic apoptotic signaling pathwayGO:200123630.016
i kappab kinase nf kappab signalingGO:000724940.016
intracellular signal transductionGO:0035556850.016
regulation of protein localization to nucleusGO:190018020.016
cellular localizationGO:0051641970.016
hematopoietic or lymphoid organ developmentGO:00485341910.016
brain developmentGO:00074202930.016
post embryonic organ developmentGO:004856940.016
positive regulation of secretion by cellGO:190353210.016
regulation of protein bindingGO:004339330.016
protein complex disassemblyGO:004324110.016
regulation of cell substrate adhesionGO:001081010.016
negative regulation of metabolic processGO:0009892860.016
response to topologically incorrect proteinGO:003596620.016
regulation of neural precursor cell proliferationGO:200017730.016
response to uvGO:000941130.016
mitotic dna damage checkpointGO:004477340.016
spermatid developmentGO:000728620.016
regulation of gtpase activityGO:004308720.016
protein secretionGO:000930610.016
cell morphogenesis involved in neuron differentiationGO:00486671630.016
sensory organ morphogenesisGO:00905962000.015
negative regulation of map kinase activityGO:004340720.015
membrane fusionGO:006102520.015
internal peptidyl lysine acetylationGO:001839320.015
positive regulation of cellular biosynthetic processGO:0031328680.015
regulation of apoptotic processGO:0042981980.015
adult behaviorGO:003053420.015
multi organism reproductive processGO:0044703360.015
cell agingGO:000756920.015
positive regulation of rna metabolic processGO:0051254590.015
single organism localizationGO:19025782250.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
specification of symmetryGO:00097992040.015
regulation of gtp catabolic processGO:003312420.015
cellular response to nutrient levelsGO:003166920.015
regulation of synapse organizationGO:005080730.015
cytoskeleton dependent cytokinesisGO:006164030.015
production of molecular mediator of immune responseGO:000244020.015
blood vessel developmentGO:00015682460.015
locomotionGO:00400113130.015
leukocyte mediated cytotoxicityGO:000190910.015
cellular response to biotic stimulusGO:007121630.015
organelle fusionGO:004828430.014
centrosome cycleGO:000709810.014
cell cycle processGO:0022402530.014
positive regulation of cellular metabolic processGO:0031325940.014
er to golgi vesicle mediated transportGO:000688810.014
regulation of organelle assemblyGO:190211540.014
positive regulation of dna metabolic processGO:005105410.014
purine ribonucleoside monophosphate catabolic processGO:000916940.014
negative regulation of defense responseGO:003134820.014
somatic cell dna recombinationGO:001644410.014
nucleoside monophosphate catabolic processGO:000912540.014
lymphocyte proliferationGO:004665110.014
carbohydrate biosynthetic processGO:001605110.014
blood vessel morphogenesisGO:00485142160.014
transcription elongation from rna polymerase ii promoterGO:000636830.014
phosphorylationGO:0016310690.014
cell migrationGO:00164772370.014
er nucleus signaling pathwayGO:000698420.014
negative regulation of cytoplasmic transportGO:190365020.014
immunoglobulin mediated immune responseGO:001606430.014
positive regulation of rna biosynthetic processGO:1902680570.014
organelle assemblyGO:00709251100.014
lateral inhibitionGO:004633110.014
positive regulation of protein polymerizationGO:003227320.014
positive regulation of cytokine productionGO:000181920.014
regulation of i kappab kinase nf kappab signalingGO:004312240.014
positive regulation of cell adhesionGO:004578510.014
positive regulation of erk1 and erk2 cascadeGO:007037420.014
ameboidal type cell migrationGO:00016671430.014
response to unfolded proteinGO:000698620.014
regulation of microtubule cytoskeleton organizationGO:007050730.014
endoplasmic reticulum unfolded protein responseGO:003096820.014
regulation of cell developmentGO:00602841000.014
nucleic acid transportGO:005065720.014
somite developmentGO:0061053960.013
entrainment of circadian clockGO:000964920.013
response to carbohydrateGO:000974330.013
negative regulation of cellular catabolic processGO:003133030.013
hemopoiesisGO:00300971830.013
cellular response to chemical stimulusGO:00708871570.013
activation of mapk activityGO:000018730.013
actin filament based movementGO:003004810.013
myeloid cell differentiationGO:0030099860.013
developmental growthGO:00485891660.013
homeostatic processGO:00425921420.013
spermatid differentiationGO:004851520.013
actin filament polymerizationGO:003004120.013
regulation of cell differentiationGO:00455951420.013
mononuclear cell proliferationGO:003294310.013
cognitionGO:005089010.013
cell morphogenesis involved in differentiationGO:00009041950.013
positive regulation of cell activationGO:005086710.013
determination of bilateral symmetryGO:00098552040.013
mitotic nuclear divisionGO:0007067180.013
response to nutrientGO:000758430.013
cellular response to molecule of bacterial originGO:007121930.013
dorsal ventral pattern formationGO:00099531250.013
negative regulation of gene expressionGO:0010629650.013
rna transportGO:005065820.013
sleepGO:003043110.013
positive regulation of myeloid cell differentiationGO:004563920.013
glucose homeostasisGO:004259310.013
regulation of multicellular organismal developmentGO:20000262230.013
stem cell differentiationGO:00488631170.013
regulation of response to cytokine stimulusGO:006075930.013
rna export from nucleusGO:000640510.013
hormone secretionGO:004687920.013
cellular response to external stimulusGO:007149620.013
negative regulation of cell communicationGO:0010648960.013
embryonic limb morphogenesisGO:003032620.013
extrinsic apoptotic signaling pathway via death domain receptorsGO:000862510.013
actin polymerization or depolymerizationGO:000815420.013
nephron morphogenesisGO:007202820.013
angiogenesisGO:00015251580.012
positive regulation of i kappab kinase nf kappab signalingGO:004312330.012
cell motilityGO:00488702440.012
peptidyl serine modificationGO:001820920.012
negative regulation of nucleobase containing compound metabolic processGO:0045934590.012
periodic partitioningGO:000736510.012
autophagyGO:000691440.012
membrane invaginationGO:001032410.012
peptidyl lysine acetylationGO:001839420.012
response to organic substanceGO:00100331530.012
synaptic growth at neuromuscular junctionGO:005112420.012
negative regulation of small gtpase mediated signal transductionGO:005105810.012
positive regulation of stem cell proliferationGO:200064810.012
regulation of cell cycleGO:0051726520.012
regulation of jak stat cascadeGO:004642530.012
lipid homeostasisGO:005508830.012
negative regulation of rna splicingGO:003311910.012
regulation of wound healingGO:006104120.012
regulation of chromosome segregationGO:005198310.012
negative regulation of catabolic processGO:000989530.012
negative regulation of protein transportGO:005122430.012
purine nucleoside monophosphate catabolic processGO:000912840.012
somatic muscle developmentGO:000752540.012
female meiotic divisionGO:000714320.012
regulation of organ growthGO:004662030.012
positive regulation of extrinsic apoptotic signaling pathwayGO:200123810.012
regulation of autophagyGO:001050630.012
immunoglobulin productionGO:000237710.012
cortical actin cytoskeleton organizationGO:003086610.012
positive regulation of muscle cell differentiationGO:005114910.012
positive regulation of immune effector processGO:000269930.012
homeostasis of number of cellsGO:0048872620.012
neuroblast proliferationGO:000740520.012
synaptic target recognitionGO:000803910.012
cell proliferationGO:0008283800.012
axon developmentGO:00615641660.012
negative regulation of innate immune responseGO:004582420.012
microtubule based processGO:0007017600.012
regulation of jun kinase activityGO:004350630.012
response to alkaloidGO:004327920.012
cellular carbohydrate metabolic processGO:004426240.012
microtubule depolymerizationGO:000701910.011
cell killingGO:000190620.011
eye developmentGO:00016542770.011
muscle cell differentiationGO:00426921390.011
peptide transportGO:001583310.011
microtubule organizing center organizationGO:003102310.011
negative regulation of cytokine productionGO:000181810.011
hormone transportGO:000991420.011
regulation of synaptic growth at neuromuscular junctionGO:000858210.011
reactive nitrogen species metabolic processGO:200105700.011
regulation of receptor mediated endocytosisGO:004825940.011
negative regulation of intracellular transportGO:003238730.011
positive regulation of epithelial cell proliferationGO:005067910.011
regulation of cellular component organizationGO:0051128860.011
negative regulation of epithelial cell proliferationGO:005068010.011
cellular respirationGO:004533330.011
immune system processGO:00023762410.011
negative regulation of transcription dna templatedGO:0045892450.011
negative regulation of sequestering of calcium ionGO:005128340.011
behaviorGO:0007610740.011
response to hexoseGO:000974630.011
regulation of reactive oxygen species metabolic processGO:200037720.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.011
sequestering of calcium ionGO:005120830.011
regulation of response to nutrient levelsGO:003210710.011
cellular response to starvationGO:000926710.011
mitotic cytokinesisGO:000028130.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
negative regulation of synapse assemblyGO:005196420.011
cellular component movementGO:00069283350.011
positive regulation of chromosome organizationGO:200125210.011
positive regulation of macromolecule metabolic processGO:0010604930.011
positive regulation of multi organism processGO:004390230.011
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.011
regulation of blood pressureGO:000821710.011
protein polyubiquitinationGO:000020940.011
cellular response to stressGO:0033554620.011
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.011
regulation of growth rateGO:004000910.011
mitochondrion organizationGO:000700540.011
cortical cytoskeleton organizationGO:003086510.011
negative regulation of nucleic acid templated transcriptionGO:1903507450.011
neuron projection morphogenesisGO:00488121610.011
endosomal transportGO:001619720.011
homophilic cell adhesion via plasma membrane adhesion moleculesGO:000715640.011
skeletal system morphogenesisGO:00487051020.011
endosome organizationGO:000703220.011
axonogenesisGO:00074091520.011
negative regulation of rna biosynthetic processGO:1902679450.011
rna modificationGO:000945120.011

rfx1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.036
nervous system diseaseDOID:86300.022
musculoskeletal system diseaseDOID:1700.015
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.014
organ system cancerDOID:005068600.014
sensory system diseaseDOID:005015500.012
eye diseaseDOID:561400.012
eye and adnexa diseaseDOID:149200.012
cardiovascular system diseaseDOID:128700.011