Danio rerio

12 known processes

sppl2

signal peptide peptidase-like 2

(Aliases: wu:fc85d12,SPPL2B,wu:fc16e01,zgc:136525)

sppl2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.049
digestive tract morphogenesisGO:00485462310.044
specification of symmetryGO:00097992040.042
cell surface receptor signaling pathwayGO:00071663250.041
determination of bilateral symmetryGO:00098552040.041
lateral inhibitionGO:004633110.040
cell morphogenesisGO:00009022890.037
positive regulation of cellular component biogenesisGO:004408930.036
chordate embryonic developmentGO:00430092710.035
positive regulation of cellular catabolic processGO:003133130.035
gastrulationGO:00073692080.034
cellular amine metabolic processGO:004410620.033
convergent extension involved in gastrulationGO:0060027710.033
positive regulation of catabolic processGO:000989640.032
regulation of cell projection assemblyGO:006049140.032
regulation of protein complex assemblyGO:004325430.031
regulation of blood vessel sizeGO:005088020.030
cellular response to external stimulusGO:007149620.030
amine metabolic processGO:000930820.030
actin polymerization or depolymerizationGO:000815420.029
response to carbohydrateGO:000974330.029
regulation of tube sizeGO:003515020.029
autophagyGO:000691440.028
digestive tract developmentGO:00485652650.028
regulation of cellular amine metabolic processGO:003323800.028
positive regulation of transportGO:005105020.028
positive regulation of cytoskeleton organizationGO:005149530.028
protein targeting to nucleusGO:004474430.027
regulation of protein polymerizationGO:003227120.027
establishment of protein localization to organelleGO:007259440.027
regulation of stem cell differentiationGO:200073640.027
gtp catabolic processGO:000618420.027
regulation of reproductive processGO:200024140.027
protein secretionGO:000930610.026
neurotransmitter transportGO:000683620.026
digestive system developmentGO:00551232890.026
negative regulation of kinase activityGO:003367340.026
proteolysis involved in cellular protein catabolic processGO:005160330.026
morphogenesis of an epitheliumGO:00020093330.026
regulation of muscle contractionGO:000693730.026
protein polymerizationGO:005125840.025
regionalizationGO:00030022740.025
regulation of blood coagulationGO:003019310.025
cellular response to nutrient levelsGO:003166920.025
agingGO:000756820.025
protein localization to nucleusGO:003450430.025
cellular component disassemblyGO:002241110.025
regulation of protein transportGO:005122330.025
tube morphogenesisGO:00352393490.025
regulation of cellular amino acid metabolic processGO:000652100.025
negative regulation of protein phosphorylationGO:000193340.024
mitochondrion organizationGO:000700540.024
establishment of endothelial barrierGO:006102830.024
protein importGO:001703830.023
regulation of autophagyGO:001050630.023
cellular component movementGO:00069283350.023
maintenance of locationGO:005123540.023
meiotic nuclear divisionGO:000712640.023
organonitrogen compound metabolic processGO:1901564740.022
synaptic vesicle localizationGO:009747910.022
cellular response to extracellular stimulusGO:003166820.022
positive regulation of protein complex assemblyGO:003133420.022
guanosine containing compound catabolic processGO:190106920.022
cell morphogenesis involved in differentiationGO:00009041950.022
single fertilizationGO:000733830.022
determination of left right symmetryGO:00073681790.022
regulation of microtubule cytoskeleton organizationGO:007050730.022
convergent extensionGO:00600261180.022
signal transductionGO:00071654550.022
modification dependent macromolecule catabolic processGO:004363230.021
negative regulation of protein kinase activityGO:000646940.021
cellular response to starvationGO:000926710.021
response to external stimulusGO:00096052640.021
synaptic growth at neuromuscular junctionGO:005112420.021
organelle organizationGO:00069962270.021
protein complex disassemblyGO:004324110.021
single organism nuclear importGO:190259330.021
cognitionGO:005089010.021
exocytosisGO:000688710.020
macroautophagyGO:001623610.020
regulation of synapse organizationGO:005080730.020
regulation of mrna processingGO:005068430.020
regulation of synapse assemblyGO:005196330.020
inositol lipid mediated signalingGO:004801720.020
regulation of nucleoside metabolic processGO:000911820.020
modification dependent protein catabolic processGO:001994130.020
system processGO:00030081850.020
regulation of purine nucleotide catabolic processGO:003312120.020
positive regulation of cytosolic calcium ion concentrationGO:000720440.019
cellular ketone metabolic processGO:0042180110.019
regulation of synaptic plasticityGO:004816710.019
positive regulation of cell cycleGO:004578730.019
regulation of cell activationGO:005086510.019
regulation of nucleotide catabolic processGO:003081120.019
macromolecular complex disassemblyGO:003298410.019
single organism organelle organizationGO:19025891990.019
sensory perception of chemical stimulusGO:000760630.019
regulation of establishment of protein localizationGO:007020140.019
regulation of gtp catabolic processGO:003312420.019
negative regulation of stem cell differentiationGO:200073720.019
cellular amide metabolic processGO:004360340.018
peptide metabolic processGO:000651810.018
ubiquitin dependent protein catabolic processGO:000651130.018
regulation of cytokine productionGO:000181730.018
regulation of signalingGO:00230512350.018
actin filament based movementGO:003004810.018
protein metabolic processGO:00195381830.018
positive regulation of secretionGO:005104710.018
regulation of primary metabolic processGO:00800903110.018
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.018
cellular amino acid metabolic processGO:000652070.018
embryonic organ morphogenesisGO:00485622740.018
symbiosis encompassing mutualism through parasitismGO:004440340.018
nuclear importGO:005117030.018
establishment of synaptic vesicle localizationGO:009748010.018
alcohol biosynthetic processGO:004616520.018
calcium ion transport into cytosolGO:006040230.018
cell motilityGO:00488702440.017
regulation of response to stimulusGO:00485832690.017
regulation of cellular ketone metabolic processGO:001056570.017
nuclear transportGO:005116940.017
meiotic cell cycle processGO:190304630.017
nucleocytoplasmic transportGO:000691340.017
adult behaviorGO:003053420.017
nuclear migrationGO:000709730.017
positive regulation of stress activated mapk cascadeGO:003287430.017
guanosine containing compound metabolic processGO:190106840.017
phagocytosisGO:000690930.017
eye developmentGO:00016542770.017
synaptic vesicle transportGO:004848910.017
protein dephosphorylationGO:000647030.017
phagocytosis engulfmentGO:000691110.017
cellular component morphogenesisGO:00329893360.017
positive regulation of purine nucleotide catabolic processGO:003312310.017
regulation of cell communicationGO:00106462320.016
regulation of systemic arterial blood pressureGO:000307310.016
regulation of metabolic processGO:00192223590.016
negative regulation of mapk cascadeGO:004340940.016
regulation of protein targetingGO:190353320.016
stem cell proliferationGO:007208940.016
regulation of striated muscle contractionGO:000694220.016
stem cell divisionGO:001714510.016
stem cell maintenanceGO:001982740.016
positive regulation of cellular amine metabolic processGO:003324000.016
chemosensory behaviorGO:000763510.016
establishment of localization in cellGO:0051649770.016
organic acid metabolic processGO:0006082310.016
regulation of blood pressureGO:000821710.016
regulation of cytoplasmic transportGO:190364940.016
regulation of rho protein signal transductionGO:003502320.016
protein import into nucleusGO:000660630.016
single organism metabolic processGO:00447102170.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
regulation of cell shapeGO:000836010.016
epithelial cell morphogenesisGO:000338220.016
response to external biotic stimulusGO:0043207970.016
response to other organismGO:0051707970.016
establishment of localizationGO:00512342440.016
cellular macromolecule metabolic processGO:00442603910.016
biosynthetic processGO:00090582940.015
phosphatidylinositol mediated signalingGO:004801520.015
regulation of filopodium assemblyGO:005148920.015
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.015
regulation of protein catabolic processGO:004217610.015
gtp metabolic processGO:004603940.015
multicellular organism growthGO:003526440.015
positive regulation of protein polymerizationGO:003227320.015
embryonic organ developmentGO:00485683810.015
heart developmentGO:00075073130.015
regulation of protein depolymerizationGO:190187910.015
negative regulation of map kinase activityGO:004340720.015
regulation of metal ion transportGO:001095940.015
negative regulation of protein serine threonine kinase activityGO:007190120.015
carboxylic acid metabolic processGO:0019752220.015
regulation of signal transductionGO:00099662250.015
positive regulation of blood circulationGO:190352420.015
sequestering of metal ionGO:005123830.015
multi organism processGO:00517041340.015
meiotic chromosome segregationGO:004513230.015
cellular component assembly involved in morphogenesisGO:00109271070.014
positive regulation of nucleoside metabolic processGO:004597910.014
cell part morphogenesisGO:00329902460.014
regulation of multicellular organismal processGO:00512392770.014
regulation of wound healingGO:006104120.014
positive regulation of nucleotide catabolic processGO:003081310.014
cell projection morphogenesisGO:00488582440.014
golgi vesicle transportGO:004819330.014
regulation of gtpase activityGO:004308720.014
production of molecular mediator of immune responseGO:000244020.014
negative regulation of cellular catabolic processGO:003133030.014
i kappab kinase nf kappab signalingGO:000724940.014
cell projection organizationGO:00300302840.014
carbohydrate homeostasisGO:003350010.014
positive regulation of cytokine productionGO:000181920.014
locomotionGO:00400113130.014
membrane invaginationGO:001032410.014
rna metabolic processGO:00160702190.014
cellular response to radiationGO:007147840.014
negative regulation of sequestering of calcium ionGO:005128340.014
neurotransmitter secretionGO:000726920.014
carbohydrate biosynthetic processGO:001605110.014
endocrine processGO:005088620.014
peptidyl threonine phosphorylationGO:001810710.014
microtubule polymerization or depolymerizationGO:003110930.014
small molecule metabolic processGO:0044281770.014
smooth muscle contractionGO:000693920.014
regulation of bindingGO:005109830.014
generation of neuronsGO:00486993850.014
protein localization to plasma membraneGO:007265910.014
regulation of protein modification by small protein conjugation or removalGO:190332030.014
positive regulation of gtpase activityGO:004354710.014
brain developmentGO:00074202930.014
regulation of protein complex disassemblyGO:004324410.014
regulation of reactive oxygen species metabolic processGO:200037720.014
developmental programmed cell deathGO:001062340.013
localization of cellGO:00516742440.013
nitrogen compound metabolic processGO:00068073190.013
regulation of multicellular organism growthGO:004001440.013
enzyme linked receptor protein signaling pathwayGO:00071671060.013
regulation of response to biotic stimulusGO:000283120.013
mechanosensory behaviorGO:000763820.013
cytosolic calcium ion transportGO:006040130.013
tissue remodelingGO:004877140.013
post golgi vesicle mediated transportGO:000689210.013
regulation of protein ubiquitinationGO:003139630.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
response to glucoseGO:000974930.013
response to biotic stimulusGO:0009607970.013
proteasomal protein catabolic processGO:001049820.013
catecholamine metabolic processGO:000658420.013
gene expressionGO:00104672520.013
transportGO:00068102200.013
response to chemicalGO:00422213200.013
response to hexoseGO:000974630.013
macromolecule modificationGO:00434121110.013
oxoacid metabolic processGO:0043436310.013
positive regulation of secretion by cellGO:190353210.013
cellular response to organic substanceGO:00713101050.013
regulation of intracellular protein transportGO:003315730.013
regulation of transporter activityGO:003240920.013
single organism localizationGO:19025782250.013
cellular biosynthetic processGO:00442492860.013
regulation of endocrine processGO:004406020.013
female sex differentiationGO:004666040.013
centrosome organizationGO:005129710.013
negative regulation of biological processGO:00485193040.013
cellular carbohydrate metabolic processGO:004426240.013
response to drugGO:004249330.013
g1 s transition of mitotic cell cycleGO:000008210.013
response to stressGO:00069502630.013
positive regulation of cell activationGO:005086710.012
ribonucleoside monophosphate catabolic processGO:000915840.012
single organism transportGO:00447652060.012
regulation of organ growthGO:004662030.012
skeletal system developmentGO:00015011810.012
vacuolar transportGO:000703420.012
release of sequestered calcium ion into cytosolGO:005120930.012
response to uvGO:000941130.012
response to monosaccharideGO:003428430.012
microtubule organizing center organizationGO:003102310.012
primary neural tube formationGO:001402010.012
phosphatidylinositol 3 kinase signalingGO:001406520.012
protein depolymerizationGO:005126110.012
organic substance biosynthetic processGO:19015762890.012
odontogenesis of dentin containing toothGO:004247510.012
erk1 and erk2 cascadeGO:007037140.012
catechol containing compound metabolic processGO:000971220.012
positive regulation of gtp catabolic processGO:003312610.012
sensory organ developmentGO:00074233930.012
negative regulation of cytokine productionGO:000181810.012
circulatory system processGO:0003013870.012
cellular protein complex disassemblyGO:004362410.012
regulation of cellular metabolic processGO:00313233200.012
neuron neuron synaptic transmissionGO:000727010.012
development of primary female sexual characteristicsGO:004654540.012
neuroblast proliferationGO:000740520.012
cellular response to chemical stimulusGO:00708871570.012
female gonad developmentGO:000858540.012
positive regulation of map kinase activityGO:004340630.012
macromolecule biosynthetic processGO:00090592270.011
centrosome cycleGO:000709810.011
regulation of protein localization to nucleusGO:190018020.011
regulation of calcium ion transportGO:005192420.011
peptide transportGO:001583310.011
cellular localizationGO:0051641970.011
compound eye developmentGO:004874920.011
epidermal cell fate specificationGO:000995740.011
negative regulation of catabolic processGO:000989530.011
cytokinesisGO:000091030.011
protein acetylationGO:000647320.011
cellular protein catabolic processGO:004425740.011
carboxylic acid catabolic processGO:004639530.011
positive regulation of immune effector processGO:000269930.011
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.011
regulation of carbohydrate metabolic processGO:000610940.011
regulation of i kappab kinase nf kappab signalingGO:004312240.011
growthGO:00400071740.011
cellular nitrogen compound metabolic processGO:00346412900.011
regulation of nitrogen compound metabolic processGO:00511712510.011
small molecule catabolic processGO:004428230.011
cellular response to oxygen levelsGO:007145310.011
retina development in camera type eyeGO:00600411460.011
dicarboxylic acid transportGO:000683510.011
regulation of hematopoietic progenitor cell differentiationGO:190153210.011
regulation of jak stat cascadeGO:004642530.011
superoxide metabolic processGO:000680120.011
leukocyte proliferationGO:007066110.011
regulation of epithelial cell proliferationGO:005067830.011
sensory perception of painGO:001923310.011
response to glucocorticoidGO:005138410.011
membrane hyperpolarizationGO:006008110.011
wound healingGO:0042060900.011
regulation of nucleic acid templated transcriptionGO:19035062130.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.011
heterocycle biosynthetic processGO:00181302150.010
regulation of protein bindingGO:004339330.010
negative regulation of signalingGO:0023057960.010
regulation of protein import into nucleusGO:004230620.010
regulation of neurological system processGO:003164420.010
heart morphogenesisGO:00030071560.010
fertilizationGO:000956630.010
regulation of nucleobase containing compound metabolic processGO:00192192500.010
negative regulation of secretionGO:005104820.010
establishment of protein localization to plasma membraneGO:009000210.010
regulation of response to nutrient levelsGO:003210710.010
regulation of biological qualityGO:00650082630.010
camera type eye developmentGO:00430102220.010
negative regulation of defense responseGO:003134820.010
somatic muscle developmentGO:000752540.010
nucleobase containing compound metabolic processGO:00061392740.010
regulation of sequestering of calcium ionGO:005128240.010
positive regulation of ras gtpase activityGO:003232010.010
internal protein amino acid acetylationGO:000647520.010
head developmentGO:00603223030.010
anterior posterior pattern specificationGO:00099521520.010
apoptotic process involved in developmentGO:190274220.010
regulation of cytokine mediated signaling pathwayGO:000195930.010
axonal defasciculationGO:000741420.010
regulation of cellular carbohydrate metabolic processGO:001067540.010
cell migrationGO:00164772370.010
extrinsic apoptotic signaling pathwayGO:009719130.010
response to amino acidGO:004320020.010
epithelial cell differentiationGO:00308551160.010
regulation of nucleocytoplasmic transportGO:004682220.010
mitochondrial transportGO:000683920.010
negative regulation of multi organism processGO:004390130.010
embryo development ending in birth or egg hatchingGO:00097922710.010
cellular response to decreased oxygen levelsGO:003629410.010

sppl2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
nervous system diseaseDOID:86300.015
musculoskeletal system diseaseDOID:1700.013
disease of metabolismDOID:001466700.013
inherited metabolic disorderDOID:65500.013
sensory system diseaseDOID:005015500.012
eye diseaseDOID:561400.012
eye and adnexa diseaseDOID:149200.012
muscle tissue diseaseDOID:6600.012
muscular diseaseDOID:008000000.012
myopathyDOID:42300.012