Danio rerio

15 known processes

top2a

topoisomerase (DNA) II alpha

(Aliases: fc08c07,MGC92574,wu:fc08c07)

top2a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
meiotic nuclear divisionGO:000712640.987
embryo development ending in birth or egg hatchingGO:00097922710.941
Worm
microtubule based processGO:0007017600.913
Fly
nuclear divisionGO:0000280230.848
Fly
macromolecule biosynthetic processGO:00090592270.719
Mouse Fly
spindle assembly involved in mitosisGO:009030710.693
spindle assemblyGO:005122520.551
cell cycleGO:0007049930.545
Fly
meiotic chromosome segregationGO:004513230.532
spindle organizationGO:000705150.514
Fly
cellular aromatic compound metabolic processGO:00067252950.506
Human Mouse Fly
reproductionGO:0000003400.503
Worm
mitotic cell cycle processGO:1903047480.496
Fly
cilium morphogenesisGO:0060271850.493
cell cycle processGO:0022402530.492
Fly
larval developmentGO:000216420.486
Worm
regulation of meiotic cell cycleGO:005144510.486
cellular nitrogen compound metabolic processGO:00346412900.450
Human Mouse Fly
nucleobase containing compound metabolic processGO:00061392740.447
Human Mouse Fly
nucleus organizationGO:000699770.435
regulation of multicellular organismal developmentGO:20000262230.427
regulation of multicellular organism growthGO:004001440.418
nucleic acid metabolic processGO:00903042440.400
Human Mouse Fly
meiosis iGO:000712710.382
regulation of nucleobase containing compound metabolic processGO:00192192500.356
Human Mouse Fly
regulation of biosynthetic processGO:00098892500.344
Mouse Fly
microtubule organizing center organizationGO:003102310.338
centrosome duplicationGO:005129810.337
regulation of multicellular organismal processGO:00512392770.337
nitrogen compound metabolic processGO:00068073190.312
Human Mouse Fly
dna metabolic processGO:0006259270.292
Human Mouse Fly
regulation of rna metabolic processGO:00512522240.286
Human Mouse Fly
developmental growthGO:00485891660.284
positive regulation of cell cycleGO:004578730.281
organic cyclic compound metabolic processGO:19013603010.271
Human Mouse Fly
gene expressionGO:00104672520.252
Mouse Worm Fly
organelle fissionGO:0048285230.250
Fly
regulation of primary metabolic processGO:00800903110.246
Human Mouse Fly
meiotic cell cycle processGO:190304630.242
regulation of gene expressionGO:00104682650.241
Mouse Worm Fly
positive regulation of biological processGO:00485182530.238
Human Mouse
cellular nitrogen compound biosynthetic processGO:00442712180.234
Mouse Fly
cellular biosynthetic processGO:00442492860.223
Mouse Fly
rna metabolic processGO:00160702190.221
Human Mouse Fly
organelle organizationGO:00069962270.214
Human Mouse Fly
cellular macromolecule metabolic processGO:00442603910.205
Human Mouse Fly
positive regulation of cellular processGO:00485222010.203
Human Mouse
heterocycle biosynthetic processGO:00181302150.203
Mouse Fly
regulation of nucleocytoplasmic transportGO:004682220.202
mitotic nuclear divisionGO:0007067180.202
Fly
biosynthetic processGO:00090582940.200
Mouse Fly
centrosome cycleGO:000709810.199
spindle assembly involved in meiosisGO:009030610.184
mitotic dna integrity checkpointGO:004477440.184
Fly
meiotic cell cycleGO:005132150.173
regulation of cellular biosynthetic processGO:00313262450.172
Mouse Fly
cytoskeleton organizationGO:0007010960.169
Fly
microtubule cytoskeleton organizationGO:0000226330.167
Fly
developmental process involved in reproductionGO:0003006270.166
regulation of transcription from rna polymerase ii promoterGO:00063571140.165
Mouse
single organism metabolic processGO:00447102170.165
Human Mouse Fly
oocyte maturationGO:000155640.164
positive regulation of cellular component biogenesisGO:004408930.162
mitotic spindle organizationGO:000705250.158
Fly
single organism nuclear importGO:190259330.156
heterocycle metabolic processGO:00464832900.154
Human Mouse Fly
cell migrationGO:00164772370.153
eye developmentGO:00016542770.150
Zebrafish
rna biosynthetic processGO:00327741810.149
Mouse Fly
regulation of nitrogen compound metabolic processGO:00511712510.143
Human Mouse Fly
positive regulation of catabolic processGO:000989640.140
regulation of cellular metabolic processGO:00313233200.140
Human Mouse Fly
digestive system developmentGO:00551232890.139
centrosome organizationGO:005129710.136
nuclear transportGO:005116940.135
mitotic cell cycleGO:0000278640.129
Fly
cell death in response to oxidative stressGO:003647320.127
aromatic compound biosynthetic processGO:00194382170.127
Mouse Fly
establishment of localizationGO:00512342440.126
Worm Fly
meiosis iiGO:000713510.119
chromosome segregationGO:0007059120.119
regulation of mitotic cell cycle phase transitionGO:190199080.119
Fly
multicellular organism growthGO:003526440.116
protein targeting to nucleusGO:004474430.111
nucleic acid templated transcriptionGO:00976591810.109
Mouse Fly
regulation of rna biosynthetic processGO:20011412130.108
Mouse Fly
cell motilityGO:00488702440.107
single organism organelle organizationGO:19025891990.105
Human Mouse Fly
female meiotic divisionGO:000714320.104
organic substance biosynthetic processGO:19015762890.103
Mouse Fly
nucleus localizationGO:005164780.103
nucleobase containing compound biosynthetic processGO:00346542050.103
Mouse Fly
regulation of macromolecule metabolic processGO:00602553170.103
Human Mouse Worm Fly
regulation of metabolic processGO:00192223590.102
Human Mouse Worm Fly
nuclear importGO:005117030.101
regenerationGO:0031099910.095
locomotionGO:00400113130.094
Zebrafish
cytokinesisGO:000091030.093
establishment of protein localization to organelleGO:007259440.093
cytokinetic processGO:003250620.093
nuclear migrationGO:000709730.093
nucleocytoplasmic transportGO:000691340.093
maturation of ssu rrnaGO:003049010.092
response to stressGO:00069502630.092
Human Fly
negative regulation of nucleobase containing compound metabolic processGO:0045934590.092
Fly
transportGO:00068102200.092
Worm
cellular localizationGO:0051641970.091
Fly
cellular component biogenesisGO:00440851780.091
regulation of protein transportGO:005122330.089
positive regulation of cellular amine metabolic processGO:003324000.087
digestive tract developmentGO:00485652650.084
regulation of cellular response to oxidative stressGO:190040720.084
positive regulation of cellular amino acid metabolic processGO:004576400.084
microtubule bundle formationGO:000157890.083
single organism localizationGO:19025782250.082
pronuclear migrationGO:003504610.082
organic substance transportGO:0071702580.082
regulation of histone methylationGO:003106030.082
amine metabolic processGO:000930820.081
protein complex subunit organizationGO:0071822460.081
Fly
positive regulation of cellular catabolic processGO:003133130.080
circulatory system processGO:0003013870.079
positive regulation of cellular biosynthetic processGO:0031328680.079
Mouse
transcription from rna polymerase ii promoterGO:0006366800.078
Mouse
localization of cellGO:00516742440.078
positive regulation of nitrogen compound metabolic processGO:0051173690.077
Human Mouse
growthGO:00400071740.077
positive regulation of rna biosynthetic processGO:1902680570.076
Mouse
cellular ketone metabolic processGO:0042180110.076
negative regulation of biological processGO:00485193040.076
Worm Fly
deathGO:00162651210.074
Human
neural retina developmentGO:0003407490.074
Zebrafish
peptidyl threonine phosphorylationGO:001810710.073
regulation of cellular ketone metabolic processGO:001056570.073
cellular process involved in reproduction in multicellular organismGO:0022412280.073
cellular component assemblyGO:00226071700.069
cellular protein modification processGO:00064641000.069
negative regulation of metabolic processGO:0009892860.069
Worm Fly
cell projection organizationGO:00300302840.067
Zebrafish
homologous chromosome segregationGO:004514310.067
chromosome organization involved in meiosisGO:007019210.067
cellular protein metabolic processGO:00442671290.065
cilium assemblyGO:0042384580.065
negative regulation of cellular processGO:00485232830.064
Fly
response to chemicalGO:00422213200.064
Zebrafish
carboxylic acid metabolic processGO:0019752220.064
cell cycle g2 m phase transitionGO:004483940.063
regulation of catalytic activityGO:0050790550.062
reciprocal meiotic recombinationGO:000713110.062
microtubule cytoskeleton organization involved in mitosisGO:190285010.062
organic acid metabolic processGO:0006082310.062
oxoacid metabolic processGO:0043436310.061
regulation of developmental processGO:00507932470.060
germ cell developmentGO:0007281220.060
spindle assembly involved in female meiosisGO:000705610.059
protein importGO:001703830.059
lateral inhibitionGO:004633110.058
cytoskeleton dependent cytokinesisGO:006164030.058
negative regulation of cellular metabolic processGO:0031324770.057
Fly
chordate embryonic developmentGO:00430092710.057
auditory receptor cell fate commitmentGO:000991240.056
regulation of cellular amino acid metabolic processGO:000652100.056
male meiosisGO:000714020.056
nuclear envelope organizationGO:000699820.055
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.055
Fly
multi organism reproductive processGO:0044703360.055
protein metabolic processGO:00195381830.055
cleavage furrow formationGO:003608920.054
fertilizationGO:000956630.053
meiotic spindle organizationGO:000021210.052
organelle localizationGO:0051640490.052
Fly
eye morphogenesisGO:00485921440.051
Zebrafish
camera type eye developmentGO:00430102220.051
Zebrafish
negative regulation of cellular catabolic processGO:003133030.050
blood vessel developmentGO:00015682460.049
organic substance catabolic processGO:1901575280.049
Human Mouse Fly
regulation of cell cycle phase transitionGO:190198780.049
Fly
rna 3 end processingGO:003112320.048
regulation of biological qualityGO:00650082630.048
regulation of establishment of protein localizationGO:007020140.048
sensory organ developmentGO:00074233930.048
Zebrafish
cell migration involved in heart developmentGO:0060973220.048
single organism reproductive processGO:0044702400.048
regulation of transcription dna templatedGO:00063552130.047
Mouse Fly
protein import into nucleusGO:000660630.047
morphogenesis of an epitheliumGO:00020093330.047
establishment of localization in cellGO:0051649770.045
Fly
embryonic digestive tract morphogenesisGO:004855730.044
positive regulation of macromolecule biosynthetic processGO:0010557590.044
Mouse
development of primary sexual characteristicsGO:004513750.044
microtubule polymerization or depolymerizationGO:003110930.044
positive regulation of chromosome organizationGO:200125210.044
cilium organizationGO:0044782710.044
cellular amino acid metabolic processGO:000652070.043
organic cyclic compound biosynthetic processGO:19013622230.043
Mouse Fly
regulation of intracellular protein transportGO:003315730.043
hematopoietic stem cell differentiationGO:0060218200.043
exocrine system developmentGO:0035272280.042
transcription dna templatedGO:00063511810.042
Mouse Fly
negative regulation of nitrogen compound metabolic processGO:0051172590.041
Fly
regulation of chromatin modificationGO:190330850.041
retina morphogenesis in camera type eyeGO:0060042790.041
Zebrafish
cellular macromolecule biosynthetic processGO:00346452240.041
Mouse Fly
regulation of mitotic cell cycleGO:0007346250.040
Fly
multicellular organism reproductionGO:0032504350.040
response to organic substanceGO:00100331530.040
chromosome organizationGO:0051276310.040
Human Mouse Fly
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046210.039
regulation of cell cycle processGO:0010564200.039
Fly
primary neural tube formationGO:001402010.039
carbohydrate derivative metabolic processGO:1901135610.039
Human Mouse Fly
multicellular organismal reproductive processGO:0048609350.039
protein homooligomerizationGO:005126030.039
protein localization to nucleusGO:003450430.038
regulation of cell activationGO:005086510.038
microtubule depolymerizationGO:000701910.038
microtubule based movementGO:0007018330.038
regulation of protein complex assemblyGO:004325430.038
regulation of cytoplasmic transportGO:190364940.038
negative regulation of gene expressionGO:0010629650.037
Worm Fly
negative regulation of apoptotic processGO:0043066550.037
single organism cellular localizationGO:1902580460.037
vasculature developmentGO:00019442780.037
negative regulation of nuclear divisionGO:005178430.036
positive regulation of transcription dna templatedGO:0045893570.036
Mouse
cell part morphogenesisGO:00329902460.036
Zebrafish
regulation of cellular amine metabolic processGO:003323800.036
mitotic sister chromatid cohesionGO:000706420.036
cell deathGO:00082191210.035
Human
regulation of response to oxidative stressGO:190288220.035
regulation of protein localization to nucleusGO:190018020.035
mitotic cytokinesisGO:000028130.035
regulation of organ growthGO:004662030.035
regulation of cellular component organizationGO:0051128860.035
positive regulation of biosynthetic processGO:0009891680.035
Mouse
single organism transportGO:00447652060.035
blood vessel morphogenesisGO:00485142160.035
blood circulationGO:0008015870.034
modification dependent macromolecule catabolic processGO:004363230.034
heart processGO:0003015710.034
intracellular transportGO:0046907320.034
cell substrate adhesionGO:003158940.034
reciprocal dna recombinationGO:003582510.034
establishment of vesicle localizationGO:0051650240.033
regulation of protein targetingGO:190353320.033
negative regulation of macromolecule metabolic processGO:0010605760.033
Worm Fly
regulation of intracellular signal transductionGO:1902531570.033
positive regulation of transportGO:005105020.033
small gtpase mediated signal transductionGO:000726480.033
single fertilizationGO:000733830.031
regulation of gene expression epigeneticGO:0040029110.031
Worm Fly
system processGO:00030081850.031
negative regulation of protein transportGO:005122430.031
behaviorGO:0007610740.031
negative regulation of response to stimulusGO:00485851040.030
regulation of protein import into nucleusGO:004230620.030
protein complex assemblyGO:0006461300.030
protein secretionGO:000930610.030
sexual reproductionGO:0019953360.030
regulation of heart growthGO:006042020.029
positive regulation of immune effector processGO:000269930.029
regulation of protein catabolic processGO:004217610.029
positive regulation of gene expressionGO:0010628710.029
Mouse
cellular component disassemblyGO:002241110.029
Human
regulation of establishment of planar polarityGO:009017540.029
positive regulation of protein complex assemblyGO:003133420.029
phosphorus metabolic processGO:00067931090.029
Human Mouse Fly
cellular component movementGO:00069283350.029
Zebrafish
embryonic organ developmentGO:00485683810.028
cell proliferationGO:0008283800.028
gamete generationGO:0007276330.028
intracellular signal transductionGO:0035556850.028
oogenesisGO:0048477140.028
neuron projection regenerationGO:0031102160.028
embryonic limb morphogenesisGO:003032620.027
angiogenesisGO:00015251580.027
cell projection morphogenesisGO:00488582440.027
Zebrafish
regulation of nucleic acid templated transcriptionGO:19035062130.027
Mouse Fly
eye photoreceptor cell developmentGO:0042462300.027
head developmentGO:00603223030.027
spermatid differentiationGO:004851520.026
organelle assemblyGO:00709251100.026
smooth muscle contractionGO:000693920.026
inner ear receptor cell fate commitmentGO:006012040.026
proximal distal pattern formationGO:000995410.026
regulation of cellular macromolecule biosynthetic processGO:20001122220.026
Mouse Fly
cellular component morphogenesisGO:00329893360.026
Zebrafish
response to antibioticGO:004667710.026
convergent extensionGO:00600261180.025
spinal cord developmentGO:0021510460.025
proteasomal protein catabolic processGO:001049820.025
regulation of cell deathGO:00109411030.025
Human
response to topologically incorrect proteinGO:003596620.025
regulation of cell cycleGO:0051726520.025
Fly
positive regulation of cellular metabolic processGO:0031325940.025
Human Mouse
tube morphogenesisGO:00352393490.024
positive regulation of nucleobase containing compound metabolic processGO:0045935690.024
Human Mouse
mitotic dna damage checkpointGO:004477340.024
Fly
endocardium morphogenesisGO:000316040.024
determination of intestine left right asymmetryGO:007190820.024
nucleoside monophosphate catabolic processGO:000912540.024
Human Mouse Fly
protein complex disassemblyGO:004324110.024
cell morphogenesisGO:00009022890.023
Zebrafish
embryonic organ morphogenesisGO:00485622740.023
organic cyclic compound catabolic processGO:1901361150.023
Human Mouse Fly
regulation of microtubule cytoskeleton organizationGO:007050730.023
negative regulation of cellular biosynthetic processGO:0031327550.023
Fly
sister chromatid segregationGO:000081960.023
Fly
negative regulation of catabolic processGO:000989530.023
regulation of reactive oxygen species metabolic processGO:200037720.023
response to drugGO:004249330.022
negative regulation of biosynthetic processGO:0009890550.022
Fly
epithalamus developmentGO:0021538100.022
exocrine pancreas developmentGO:0031017280.022
regulation of peptidase activityGO:0052547230.022
embryonic heart tube morphogenesisGO:00031431080.022
regulation of protein depolymerizationGO:190187910.022
heart morphogenesisGO:00030071560.022
regulation of macromolecule biosynthetic processGO:00105562250.022
Mouse Fly
cell substrate junction assemblyGO:000704420.022
regulation of mrna processingGO:005068430.022
cellular response to radiationGO:007147840.021
regulation of cyclin dependent protein serine threonine kinase activityGO:000007910.021
dna modificationGO:000630480.021
reproductive processGO:0022414400.021
negative regulation of cell communicationGO:0010648960.021
neuronal stem cell maintenanceGO:009715020.021
negative regulation of transcription dna templatedGO:0045892450.021
Fly
muscle tissue developmentGO:00605371100.021
heart loopingGO:0001947940.021
positive regulation of cytoskeleton organizationGO:005149530.021
gastrulationGO:00073692080.021
negative regulation of cell cycle phase transitionGO:190198850.021
Fly
distal tubule developmentGO:007201710.021
response to abiotic stimulusGO:00096281220.021
atp catabolic processGO:000620040.021
Human Mouse Fly
developmental programmed cell deathGO:001062340.021
nerve developmentGO:0021675450.021
regulation of production of molecular mediator of immune responseGO:000270010.020
establishment of organelle localizationGO:0051656450.020
Fly
bmp signaling pathway involved in heart developmentGO:0061312150.020
dna alkylationGO:000630580.020
regulation of cell agingGO:009034210.020
neural crest cell differentiationGO:0014033720.020
regulation of organelle assemblyGO:190211540.020
cellular response to chemical stimulusGO:00708871570.020
digestive tract morphogenesisGO:00485462310.020
dna methylation or demethylationGO:004472880.020
regulation of reproductive processGO:200024140.020
regulation of localizationGO:00328791040.019
cellular macromolecular complex assemblyGO:0034622240.019
regulation of system processGO:0044057400.019
regulation of programmed cell deathGO:00430671010.019
Human
embryonic skeletal joint developmentGO:007249830.019
negative regulation of chemotaxisGO:005092240.019
axonal defasciculationGO:000741420.019
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.019
response to woundingGO:00096111160.019
regulation of blood circulationGO:1903522320.019
golgi organizationGO:000703010.019
striated muscle tissue developmentGO:00147061100.019
regulation of chromosome segregationGO:005198310.019
autophagyGO:000691440.019
peptidyl threonine modificationGO:001821010.018
cell surface receptor signaling pathwayGO:00071663250.018
regulation of purine nucleotide catabolic processGO:003312120.018
positive regulation of chromatin modificationGO:190331010.018
organonitrogen compound metabolic processGO:1901564740.018
Human Mouse Fly
heart contractionGO:0060047710.018
interspecies interaction between organismsGO:004441940.017
Human
regulation of apoptotic processGO:0042981980.017
Human
phosphorylationGO:0016310690.017
pectoral fin developmentGO:0033339500.017
establishment of nucleus localizationGO:004002370.017
retina layer formationGO:0010842240.017
Zebrafish
mesenchymal cell proliferationGO:001046310.017
negative regulation of macromolecule biosynthetic processGO:0010558480.017
Fly
spermatid developmentGO:000728620.017
regulation of nucleotide catabolic processGO:003081120.017
axial mesoderm formationGO:004832040.017
kidney vasculature developmentGO:006144020.017
cellular response to organic substanceGO:00713101050.017
basement membrane assemblyGO:007083130.017
posttranscriptional regulation of gene expressionGO:0010608140.017
Worm
ras protein signal transductionGO:000726570.017
mitotic g2 dna damage checkpointGO:000709530.016
Fly
response to uvGO:000941130.016
cellular response to unfolded proteinGO:003462020.016
positive regulation of purine nucleotide catabolic processGO:003312310.016
protein modification processGO:00362111000.016
regulation of cell divisionGO:0051302120.016
negative regulation of protein import into nucleusGO:004230820.016
regulation of developmental growthGO:0048638380.016
macromolecular complex subunit organizationGO:0043933740.016
Fly
macromolecule modificationGO:00434121110.016
positive regulation of nucleoside metabolic processGO:004597910.016
regulation of cellular component sizeGO:0032535300.016
positive regulation of macromolecule metabolic processGO:0010604930.015
Human Mouse
regulation of protein maturationGO:1903317100.015
regulation of anatomical structure sizeGO:0090066330.015
regulation of peptidyl tyrosine phosphorylationGO:005073010.015
regulation of cell cycle g2 m phase transitionGO:190274940.015
response to steroid hormoneGO:0048545350.015
purine ribonucleoside monophosphate catabolic processGO:000916940.015
Human Mouse Fly
macromolecular complex assemblyGO:0065003350.015
female gamete generationGO:0007292140.015
neural crest cell developmentGO:0014032620.015
renal system process involved in regulation of blood volumeGO:000197710.015
positive regulation of endothelial cell differentiationGO:004560320.015
sex differentiationGO:000754850.015
modification dependent protein catabolic processGO:001994130.015
positive regulation of rna metabolic processGO:0051254590.015
Human Mouse
negative regulation of rna metabolic processGO:0051253480.014
Fly
proteolysis involved in cellular protein catabolic processGO:005160330.014
regulation of growthGO:0040008420.014
tube closureGO:006060610.014
guanosine containing compound metabolic processGO:190106840.014
astral microtubule organizationGO:003095310.014
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.014
regulation of blood pressureGO:000821710.014
negative regulation of ras protein signal transductionGO:004658010.014
protein localizationGO:0008104400.014
regulation of jak stat cascadeGO:004642530.014
positive regulation of ras protein signal transductionGO:004657910.014
negative regulation of cellular component organizationGO:0051129160.014
smoothened signaling pathwayGO:0007224300.014
cellular response to reactive oxygen speciesGO:003461420.014
female meiosis chromosome segregationGO:001632110.014
regulation of molecular functionGO:0065009700.014
positive regulation of metabolic processGO:00098931080.014
Human Mouse
olfactory bulb developmentGO:002177240.014
endodermal digestive tract morphogenesisGO:006103120.014
positive regulation of map kinase activityGO:004340630.014
regulation of cellular protein catabolic processGO:190336210.014
microtubule polymerizationGO:004678520.013
sister chromatid cohesionGO:000706220.013
positive regulation of histone modificationGO:003105810.013
regulation of oxidative stress induced cell deathGO:190320120.013
retinal ganglion cell axon guidanceGO:0031290350.013
Zebrafish
cellular response to biotic stimulusGO:007121630.013
stem cell fate commitmentGO:004886510.013
photoreceptor cell fate commitmentGO:004655210.013
endocardium formationGO:006021410.013
ventral spinal cord interneuron specificationGO:002152130.013
response to other organismGO:0051707970.013
response to radiationGO:0009314510.013
g2 m transition of mitotic cell cycleGO:000008640.013
regulation of neuron differentiationGO:0045664560.013
cranial nerve developmentGO:0021545420.013
positive regulation of nucleotide catabolic processGO:003081310.013
ribonucleoside monophosphate catabolic processGO:000915840.013
Human Mouse Fly
regulation of proteolysisGO:0030162240.013
negative regulation of neuron projection regenerationGO:007057140.013
b cell activationGO:004211320.012
agingGO:000756820.012
cellular response to oxygen levelsGO:007145310.012
heterophilic cell cell adhesion via plasma membrane cell adhesion moleculesGO:000715720.012
single organism intracellular transportGO:1902582250.012
negative regulation of protein kinase activityGO:000646940.012
maintenance of locationGO:005123540.012
positive regulation of mesodermal cell fate specificationGO:004833710.012
negative regulation of cell cycleGO:0045786140.012
Fly
negative regulation of intracellular transportGO:003238730.012
intrinsic apoptotic signaling pathwayGO:0097193200.012
regionalizationGO:00030022740.012
negative regulation of kinase activityGO:003367340.012
regulation of cell sizeGO:0008361290.012
developmental growth involved in morphogenesisGO:0060560860.012
somatic muscle developmentGO:000752540.012
regulation of response to stimulusGO:00485832690.012
cellular response to decreased oxygen levelsGO:003629410.011
protein polymerizationGO:005125840.011
macromolecular complex disassemblyGO:003298410.011
lipid storageGO:001991510.011
muscle structure developmentGO:00610611960.011
negative regulation of dna metabolic processGO:005105340.011
negative regulation of signal transductionGO:0009968940.011
central nervous system developmentGO:00074173870.011
positive regulation of nucleic acid templated transcriptionGO:1903508570.011
Mouse
ventral spinal cord interneuron fate commitmentGO:006057930.011
positive regulation of cell divisionGO:005178120.011
negative regulation of dna replicationGO:000815620.011
histone deacetylationGO:001657520.011
cellular protein complex assemblyGO:0043623190.011
fin regenerationGO:0031101510.011
negative regulation of chromosome organizationGO:200125110.011
regulation of cell projection assemblyGO:006049140.011
response to oxidative stressGO:0006979110.011
negative regulation of cell deathGO:0060548600.011
phosphate containing compound metabolic processGO:00067961080.011
Human Mouse Fly

top2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.026
cancerDOID:16200.026
disease of anatomical entityDOID:700.025
immune system diseaseDOID:291400.025
hematopoietic system diseaseDOID:7400.021
bone marrow diseaseDOID:496100.020
nervous system diseaseDOID:86300.016
musculoskeletal system cancerDOID:006010000.011
organ system cancerDOID:005068600.011