Danio rerio

77 known processes

chuk

conserved helix-loop-helix ubiquitous kinase

(Aliases: zgc:56539,ikk1,MGC56539)

chuk biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
aromatic compound biosynthetic processGO:00194382170.603
Human
modification dependent macromolecule catabolic processGO:004363230.474
negative regulation of cellular processGO:00485232830.457
modification dependent protein catabolic processGO:001994130.426
cellular nitrogen compound metabolic processGO:00346412900.419
Human Fly
nucleic acid metabolic processGO:00903042440.416
Human
ubiquitin dependent protein catabolic processGO:000651130.412
negative regulation of biological processGO:00485193040.395
rna metabolic processGO:00160702190.379
Human
regulation of cellular metabolic processGO:00313233200.324
Human Fly
larval developmentGO:000216420.316
cellular aromatic compound metabolic processGO:00067252950.304
Human
regulation of defense responseGO:0031347140.301
Fly
regulation of nucleic acid templated transcriptionGO:19035062130.296
Human
proteasomal protein catabolic processGO:001049820.286
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.267
nucleobase containing compound metabolic processGO:00061392740.267
Human
regionalizationGO:00030022740.265
cell surface receptor signaling pathwayGO:00071663250.256
regulation of signal transductionGO:00099662250.248
regulation of metabolic processGO:00192223590.231
Human Fly
response to external stimulusGO:00096052640.230
Fly
cellular macromolecule metabolic processGO:00442603910.228
Human Mouse Fly
meiosis iGO:000712710.220
signal transductionGO:00071654550.210
heterocycle biosynthetic processGO:00181302150.205
Human
gene expressionGO:00104672520.202
Human
heart developmentGO:00075073130.202
organic cyclic compound metabolic processGO:19013603010.198
Human
erythrocyte homeostasisGO:0034101550.189
cellular macromolecule biosynthetic processGO:00346452240.186
Human
nitrogen compound metabolic processGO:00068073190.185
Human Fly
biosynthetic processGO:00090582940.184
Human Fly
regulation of cell deathGO:00109411030.183
digestive tract developmentGO:00485652650.180
regulation of cellular biosynthetic processGO:00313262450.167
Human Fly
cellular protein catabolic processGO:004425740.162
regulation of cellular macromolecule biosynthetic processGO:20001122220.161
Human
negative regulation of response to stimulusGO:00485851040.161
regulation of response to stimulusGO:00485832690.160
regulation of nucleobase containing compound metabolic processGO:00192192500.149
Human
regulation of biological qualityGO:00650082630.146
Mouse
response to abiotic stimulusGO:00096281220.142
morphogenesis of an epitheliumGO:00020093330.142
proteolysis involved in cellular protein catabolic processGO:005160330.140
regulation of gene expressionGO:00104682650.138
Human
regulation of cell shapeGO:000836010.136
nuclear transportGO:005116940.131
heterocycle metabolic processGO:00464832900.128
Human
response to external biotic stimulusGO:0043207970.128
Fly
regulation of macromolecule metabolic processGO:00602553170.127
Human
regulation of rna metabolic processGO:00512522240.127
Human
protein metabolic processGO:00195381830.125
Human Mouse Fly
peptidyl serine phosphorylationGO:001810510.125
Fly
cytokinetic processGO:003250620.124
sensory organ morphogenesisGO:00905962000.117
somitogenesisGO:0001756870.114
organic substance biosynthetic processGO:19015762890.113
Human Fly
rna biosynthetic processGO:00327741810.109
Human
response to chemicalGO:00422213200.109
Human
regulation of biosynthetic processGO:00098892500.109
Human Fly
anterior posterior pattern specificationGO:00099521520.101
i kappab kinase nf kappab signalingGO:000724940.101
regulation of primary metabolic processGO:00800903110.096
Human
nucleobase containing compound biosynthetic processGO:00346542050.094
Human
macromolecule biosynthetic processGO:00090592270.094
Human
regulation of cell communicationGO:00106462320.094
cell morphogenesisGO:00009022890.092
programmed cell deathGO:00125011190.090
hindbrain developmentGO:0030902910.088
positive regulation of cellular processGO:00485222010.084
Human Mouse Fly
cellular macromolecule catabolic processGO:0044265120.082
digestive tract morphogenesisGO:00485462310.082
sensory organ developmentGO:00074233930.081
morphogenesis of an epithelial sheetGO:0002011490.079
organic cyclic compound biosynthetic processGO:19013622230.077
Human
transcription from rna polymerase ii promoterGO:0006366800.077
Human
regulation of mrna splicing via spliceosomeGO:004802430.076
blood vessel developmentGO:00015682460.074
cellular component morphogenesisGO:00329893360.074
epiboly involved in gastrulation with mouth forming secondGO:0055113350.073
cell migrationGO:00164772370.068
apoptotic processGO:00069151160.067
muscle cell differentiationGO:00426921390.064
organic substance catabolic processGO:1901575280.064
Fly
regulation of i kappab kinase nf kappab signalingGO:004312240.064
developmental growthGO:00485891660.064
sequestering of metal ionGO:005123830.063
somite developmentGO:0061053960.062
regulation of protein catabolic processGO:004217610.062
homeostatic processGO:00425921420.061
single organism metabolic processGO:00447102170.058
negative regulation of signal transductionGO:0009968940.057
regulation of nucleocytoplasmic transportGO:004682220.056
central nervous system developmentGO:00074173870.056
rna modificationGO:000945120.056
peptidyl serine modificationGO:001820920.056
Fly
regulation of developmental processGO:00507932470.055
meiotic nuclear divisionGO:000712640.054
cell adhesionGO:0007155400.054
protein modification processGO:00362111000.054
Human Mouse Fly
single organism organelle organizationGO:19025891990.053
regulation of signalingGO:00230512350.053
cellular protein modification processGO:00064641000.053
Human Mouse Fly
cellular component movementGO:00069283350.052
intracellular signal transductionGO:0035556850.052
homeostasis of number of cellsGO:0048872620.051
negative regulation of apoptotic processGO:0043066550.050
regulation of rna biosynthetic processGO:20011412130.050
Human
dna biosynthetic processGO:007189730.049
negative regulation of cell communicationGO:0010648960.049
establishment of protein localization to organelleGO:007259440.049
gastrulation with mouth forming secondGO:0001702440.048
regulation of transcription dna templatedGO:00063552130.047
Human
ameboidal type cell migrationGO:00016671430.047
regulation of apoptotic processGO:0042981980.047
response to salt stressGO:0009651100.046
nucleic acid templated transcriptionGO:00976591810.046
Human
positive regulation of biological processGO:00485182530.045
Human Mouse Fly
protein importGO:001703830.045
cell cycle g1 s phase transitionGO:004484310.045
immune system processGO:00023762410.044
Mouse Fly
regulation of multicellular organism growthGO:004001440.044
nik nf kappab signalingGO:003806110.044
cellular protein metabolic processGO:00442671290.043
Human Mouse Fly
tube morphogenesisGO:00352393490.043
deathGO:00162651210.042
oxoacid metabolic processGO:0043436310.042
cellular response to stressGO:0033554620.042
regulation of programmed cell deathGO:00430671010.042
alternative mrna splicing via spliceosomeGO:000038010.042
specification of symmetryGO:00097992040.041
cell proliferationGO:0008283800.041
Mouse
nucleocytoplasmic transportGO:000691340.041
regulation of mrna stabilityGO:004348840.040
negative regulation of sequestering of calcium ionGO:005128340.040
maintenance of locationGO:005123540.039
enzyme linked receptor protein signaling pathwayGO:00071671060.038
positive regulation of cytosolic calcium ion concentrationGO:000720440.038
metencephalon developmentGO:0022037270.038
transmembrane receptor protein tyrosine kinase signaling pathwayGO:0007169420.038
skeletal muscle organ developmentGO:0060538780.037
erythrocyte differentiationGO:0030218540.037
cellular biosynthetic processGO:00442492860.037
Human Fly
negative regulation of cell deathGO:0060548600.036
cell deathGO:00082191210.036
regulation of mrna processingGO:005068430.035
muscle organ developmentGO:00075171010.035
growthGO:00400071740.035
locomotionGO:00400113130.035
regulation of cell proliferationGO:0042127370.035
microtubule cytoskeleton organizationGO:0000226330.035
striated muscle tissue developmentGO:00147061100.034
regulation of cytokine productionGO:000181730.034
axonogenesisGO:00074091520.034
multicellular organism growthGO:003526440.034
transcription dna templatedGO:00063511810.034
Human
establishment of localizationGO:00512342440.034
Mouse
cytoskeleton organizationGO:0007010960.034
camera type eye morphogenesisGO:00485931080.034
ear developmentGO:00435831270.034
response to uvGO:000941130.033
telomere organizationGO:003220010.033
negative regulation of protein phosphorylationGO:000193340.032
regulation of cellular protein metabolic processGO:0032268520.032
organonitrogen compound metabolic processGO:1901564740.032
Fly
histone modificationGO:0016570200.032
eye developmentGO:00016542770.032
epibolyGO:0090504410.032
single organism nuclear importGO:190259330.031
single organism localizationGO:19025782250.031
Mouse
positive regulation of transportGO:005105020.030
developmental growth involved in morphogenesisGO:0060560860.030
embryonic organ morphogenesisGO:00485622740.030
positive regulation of catabolic processGO:000989640.029
organelle organizationGO:00069962270.029
regulation of intracellular protein transportGO:003315730.029
protein localization to nucleusGO:003450430.029
heart morphogenesisGO:00030071560.028
cellular nitrogen compound biosynthetic processGO:00442712180.027
Human Fly
embryonic skeletal system developmentGO:0048706970.027
positive regulation of biosynthetic processGO:0009891680.027
Human Fly
myeloid cell homeostasisGO:0002262560.027
regulation of macromolecule biosynthetic processGO:00105562250.027
Human
cellular response to oxygen levelsGO:007145310.027
transportGO:00068102200.027
Mouse
macromolecule modificationGO:00434121110.027
Human Mouse Fly
regulation of neuron differentiationGO:0045664560.026
regulation of protein ubiquitinationGO:003139630.026
rna splicingGO:0008380160.026
retina morphogenesis in camera type eyeGO:0060042790.025
response to stressGO:00069502630.025
Fly
mitochondrion organizationGO:000700540.024
connective tissue developmentGO:0061448990.024
nuclear importGO:005117030.024
skeletal system morphogenesisGO:00487051020.024
stem cell divisionGO:001714510.024
double strand break repair via homologous recombinationGO:000072410.024
negative regulation of signalingGO:0023057960.024
regulation of multicellular organismal processGO:00512392770.024
symbiosis encompassing mutualism through parasitismGO:004440340.024
regulation of anatomical structure morphogenesisGO:00226031300.024
organelle fissionGO:0048285230.023
angiogenesisGO:00015251580.023
cortical cytoskeleton organizationGO:003086510.023
embryonic organ developmentGO:00485683810.023
purine nucleoside monophosphate catabolic processGO:000912840.023
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.023
convergent extensionGO:00600261180.023
cellular response to light stimulusGO:007148240.023
compound eye developmentGO:004874920.023
g1 s transition of mitotic cell cycleGO:000008210.023
positive regulation of nucleobase containing compound metabolic processGO:0045935690.023
Human
positive regulation of cytokine productionGO:000181920.022
recombinational repairGO:000072510.022
unidimensional cell growthGO:000982650.022
regulation of cardiac muscle tissue developmentGO:005502410.021
protein ubiquitination involved in ubiquitin dependent protein catabolic processGO:004278710.021
protein import into nucleusGO:000660630.021
cell projection morphogenesisGO:00488582440.021
positive regulation of cellular catabolic processGO:003133130.021
extracellular structure organizationGO:0043062270.021
protein polyubiquitinationGO:000020940.021
response to light stimulusGO:0009416460.020
posttranscriptional regulation of gene expressionGO:0010608140.020
negative regulation of defense responseGO:003134820.020
striated muscle cell differentiationGO:00511461290.020
negative regulation of intrinsic apoptotic signaling pathwayGO:200124380.020
positive regulation of protein complex assemblyGO:003133420.020
response to other organismGO:0051707970.020
Fly
small molecule metabolic processGO:0044281770.020
regulation of nucleoside metabolic processGO:000911820.020
regulation of protein import into nucleusGO:004230620.020
regulation of response to biotic stimulusGO:000283120.020
Fly
regulation of cellular protein catabolic processGO:190336210.020
cell migration involved in gastrulationGO:0042074790.019
centrosome organizationGO:005129710.019
multi organism processGO:00517041340.019
Fly
cell cycleGO:0007049930.018
cerebellum developmentGO:0021549170.018
cell motilityGO:00488702440.018
telomere maintenanceGO:000072310.018
agingGO:000756820.018
head developmentGO:00603223030.018
thermosensory behaviorGO:004004010.018
rna stabilizationGO:004348940.018
atp synthesis coupled electron transportGO:004277310.018
response to radiationGO:0009314510.018
cation transportGO:0006812810.018
gastrulationGO:00073692080.018
nucleic acid transportGO:005065720.018
centrosome cycleGO:000709810.018
cell morphogenesis involved in neuron differentiationGO:00486671630.018
embryonic limb morphogenesisGO:003032620.018
cellular amino acid metabolic processGO:000652070.018
taxisGO:00423301090.017
regulation of alternative mrna splicing via spliceosomeGO:000038110.017
synaptic growth at neuromuscular junctionGO:005112420.017
muscle structure developmentGO:00610611960.017
cellular response to chemical stimulusGO:00708871570.017
Human
intrinsic apoptotic signaling pathwayGO:0097193200.017
protein k48 linked ubiquitinationGO:007093610.017
regulation of nitrogen compound metabolic processGO:00511712510.017
Human Fly
carbohydrate biosynthetic processGO:001605110.017
er to golgi vesicle mediated transportGO:000688810.017
response to organic substanceGO:00100331530.017
Human
immune responseGO:0006955280.017
Fly
chromosome organization involved in meiosisGO:007019210.016
regulation of growthGO:0040008420.016
regulation of protein metabolic processGO:0051246560.016
regulation of tube sizeGO:003515020.016
calcium ion transport into cytosolGO:006040230.016
regulation of nucleotide catabolic processGO:003081120.016
negative regulation of programmed cell deathGO:0043069580.016
regulation of protein targetingGO:190353320.016
immune system developmentGO:00025201910.016
Mouse
response to endogenous stimulusGO:0009719830.016
atp catabolic processGO:000620040.016
regulation of response to stressGO:0080134360.016
Fly
blood vessel morphogenesisGO:00485142160.016
cellular response to dna damage stimulusGO:0006974240.016
inner ear developmentGO:00488391260.016
negative regulation of intracellular signal transductionGO:1902532220.016
homologous chromosome segregationGO:004514310.016
protein modification by small protein conjugation or removalGO:0070647140.016
cellular response to growth factor stimulusGO:0071363390.016
regulation of cell sizeGO:0008361290.016
neuron projection morphogenesisGO:00488121610.016
carboxylic acid metabolic processGO:0019752220.015
regulation of dendrite developmentGO:005077330.015
regulation of metal ion transportGO:001095940.015
regulation of synaptic growth at neuromuscular junctionGO:000858210.015
fertilizationGO:000956630.015
chemosensory behaviorGO:000763510.015
regulation of developmental growthGO:0048638380.015
regulation of transcription from rna polymerase ii promoter in response to stressGO:004361800.015
cellular amino acid biosynthetic processGO:000865220.015
cellular carbohydrate metabolic processGO:004426240.015
ribosomal small subunit biogenesisGO:004227420.015
chordate embryonic developmentGO:00430092710.015
negative regulation of chemotaxisGO:005092240.015
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.015
cell projection organizationGO:00300302840.015
cytokinesisGO:000091030.015
axis specificationGO:0009798430.015
g protein coupled receptor signaling pathwayGO:0007186740.015
mrna splicing via spliceosomeGO:0000398100.015
sequestering of calcium ionGO:005120830.015
tissue remodelingGO:004877140.015
meiotic cell cycle processGO:190304630.015
innate immune responseGO:0045087130.015
Fly
cell death in response to oxidative stressGO:003647320.015
spindle assemblyGO:005122520.014
axon guidanceGO:0007411860.014
ion homeostasisGO:0050801410.014
hemopoiesisGO:00300971830.014
Mouse
skeletal muscle tissue developmentGO:0007519670.014
positive regulation of small gtpase mediated signal transductionGO:005105710.014
multicellular organismal reproductive processGO:0048609350.014
b cell activationGO:004211320.014
regulation of phosphate metabolic processGO:0019220430.014
negative regulation of cytokine productionGO:000181810.014
endocrine processGO:005088620.014
proteolysisGO:0006508380.014
negative regulation of catabolic processGO:000989530.014
neural tube patterningGO:0021532330.013
segmentationGO:0035282970.013
sulfur compound biosynthetic processGO:004427290.013
rna localizationGO:000640340.013
organonitrogen compound biosynthetic processGO:1901566470.013
Fly
neuroblast proliferationGO:000740520.013
gtp metabolic processGO:004603940.013
reactive oxygen species biosynthetic processGO:190340910.013
cellular amine metabolic processGO:004410620.013
regulation of cellular amino acid metabolic processGO:000652100.013
negative regulation of apoptotic signaling pathwayGO:2001234100.013
entrainment of circadian clock by photoperiodGO:004315310.013
actin filament based movementGO:003004810.013
biological adhesionGO:0022610400.013
organic acid metabolic processGO:0006082310.013
cellular response to lipidGO:0071396390.013
cellular response to starvationGO:000926710.013
stem cell proliferationGO:007208940.013
intrinsic apoptotic signaling pathway by p53 class mediatorGO:007233290.013
cellular response to decreased oxygen levelsGO:003629410.012
myeloid cell developmentGO:0061515320.012
amine metabolic processGO:000930820.012
double strand break repairGO:000630230.012
response to xenobiotic stimulusGO:0009410450.012
regulation of circadian rhythmGO:004275240.012
regulation of reactive oxygen species metabolic processGO:200037720.012
apoptotic signaling pathwayGO:0097190230.012
regulation of stem cell proliferationGO:007209120.012
cell part morphogenesisGO:00329902460.012
axon developmentGO:00615641660.012
cellular response to topologically incorrect proteinGO:003596720.012
establishment of apical basal cell polarityGO:003508920.012
microtubule based processGO:0007017600.012
negative regulation of metabolic processGO:0009892860.012
phosphorylationGO:0016310690.012
Human Mouse Fly
negative regulation of macromolecule metabolic processGO:0010605760.012
regulation of insulin like growth factor receptor signaling pathwayGO:004356710.012
signal transduction by p53 class mediatorGO:0072331130.012
cell morphogenesis involved in differentiationGO:00009041950.012
macromolecule localizationGO:0033036540.012
embryonic cranial skeleton morphogenesisGO:0048701900.012
regulation of innate immune responseGO:0045088110.012
Fly
specification of organ identityGO:001009220.012
cellular response to hypoxiaGO:007145610.012
female meiotic divisionGO:000714320.012
spindle assembly involved in meiosisGO:009030610.011
cell substrate adhesionGO:003158940.011
g2 dna damage checkpointGO:003157230.011
internal peptidyl lysine acetylationGO:001839320.011
mucopolysaccharide metabolic processGO:190351020.011
ribonucleoside monophosphate catabolic processGO:000915840.011
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.011
organelle assemblyGO:00709251100.011
positive regulation of striated muscle tissue developmentGO:004584410.011
mononuclear cell proliferationGO:003294310.011
macromolecular complex subunit organizationGO:0043933740.011
regulation of cellular ketone metabolic processGO:001056570.011
multi organism reproductive processGO:0044703360.011
digestive system developmentGO:00551232890.011
neuron differentiationGO:00301823530.011
negative regulation of protein kinase activityGO:000646940.011
regulation of neural precursor cell proliferationGO:200017730.011
microtubule organizing center organizationGO:003102310.011
negative regulation of response to cytokine stimulusGO:006076120.011
cellular response to radiationGO:007147840.011
cell cycle processGO:0022402530.011
regulation of cytoplasmic transportGO:190364940.010
lipid storageGO:001991510.010
cellular component disassemblyGO:002241110.010
toll like receptor signaling pathwayGO:000222440.010
hematopoietic or lymphoid organ developmentGO:00485341910.010
Mouse
positive regulation of muscle cell differentiationGO:005114910.010
reciprocal dna recombinationGO:003582510.010
wnt signaling pathwayGO:0016055800.010
phototransduction visible lightGO:000760320.010
peptidyl amino acid modificationGO:0018193160.010
Fly
forebrain developmentGO:0030900960.010
cellular response to vascular endothelial growth factor stimulusGO:003592430.010
negative regulation of protein serine threonine kinase activityGO:007190120.010
mrna processingGO:0006397140.010
developmental programmed cell deathGO:001062340.010
retina development in camera type eyeGO:00600411460.010
positive regulation of blood circulationGO:190352420.010

chuk disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.025
eye and adnexa diseaseDOID:149200.021
nervous system diseaseDOID:86300.021
sensory system diseaseDOID:005015500.021
mitochondrial metabolism diseaseDOID:70000.011
inherited metabolic disorderDOID:65500.011
disease of metabolismDOID:001466700.011
central nervous system diseaseDOID:33100.010
neurodegenerative diseaseDOID:128900.010