Danio rerio

17 known processes

hmgcra

3-hydroxy-3-methylglutaryl-Coenzyme A reductase a

(Aliases: zgc:136576,si:ch211-129a6.5,hmgcr1a)

hmgcra biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.054
multicellular organism growthGO:003526440.054
positive regulation of transportGO:005105020.054
maintenance of locationGO:005123540.048
agingGO:000756820.046
regulation of multicellular organism growthGO:004001440.043
response to drugGO:004249330.040
signal transductionGO:00071654550.040
lipid storageGO:001991510.038
embryonic organ developmentGO:00485683810.034
adult behaviorGO:003053420.034
cognitionGO:005089010.034
regulation of synapse organizationGO:005080730.033
heart developmentGO:00075073130.033
gene expressionGO:00104672520.031
dicarboxylic acid transportGO:000683510.030
regulation of tube sizeGO:003515020.030
regulation of synapse assemblyGO:005196330.030
protein localization to nucleusGO:003450430.030
regulation of synaptic plasticityGO:004816710.029
guanosine containing compound metabolic processGO:190106840.029
stem cell proliferationGO:007208940.029
synaptic growth at neuromuscular junctionGO:005112420.028
regulation of cytokine productionGO:000181730.028
phagocytosisGO:000690930.028
regulation of synaptic growth at neuromuscular junctionGO:000858210.028
guanosine containing compound catabolic processGO:190106920.028
positive regulation of cell cycleGO:004578730.028
regulation of establishment of protein localizationGO:007020140.028
positive regulation of cellular catabolic processGO:003133130.027
nitrogen compound metabolic processGO:00068073190.027
transportGO:00068102200.027
response to chemicalGO:00422213200.027
establishment of localizationGO:00512342440.026
embryonic organ morphogenesisGO:00485622740.026
cellular response to external stimulusGO:007149620.026
regulation of circadian rhythmGO:004275240.026
stem cell maintenanceGO:001982740.026
sensory organ developmentGO:00074233930.026
cellular macromolecule metabolic processGO:00442603910.026
meiotic cell cycle processGO:190304630.026
gtp metabolic processGO:004603940.026
regulation of cellular amine metabolic processGO:003323800.025
regulation of blood pressureGO:000821710.025
regulation of metabolic processGO:00192223590.025
response to nutrientGO:000758430.025
positive regulation of catabolic processGO:000989640.025
positive regulation of cellular component biogenesisGO:004408930.025
regulation of reproductive processGO:200024140.025
single organism localizationGO:19025782250.025
regulation of protein transportGO:005122330.025
response to external stimulusGO:00096052640.025
regulation of blood vessel sizeGO:005088020.024
amino acid transportGO:000686520.024
small molecule metabolic processGO:0044281770.024
Yeast
locomotionGO:00400113130.024
nuclear importGO:005117030.024
sensory perception of chemical stimulusGO:000760630.024
nucleocytoplasmic transportGO:000691340.024
protein localization to plasma membraneGO:007265910.023
system processGO:00030081850.023
multi organism processGO:00517041340.023
regulation of biological qualityGO:00650082630.023
regulation of cytoplasmic transportGO:190364940.023
cellular amine metabolic processGO:004410620.023
response to vitaminGO:003327330.023
regulation of multicellular organismal processGO:00512392770.023
meiotic nuclear divisionGO:000712640.023
establishment of protein localization to organelleGO:007259440.023
golgi vesicle transportGO:004819330.023
cellular nitrogen compound metabolic processGO:00346412900.023
amine metabolic processGO:000930820.022
regulation of response to stimulusGO:00485832690.022
protein import into nucleusGO:000660630.022
regulation of nucleocytoplasmic transportGO:004682220.022
autophagyGO:000691440.022
cellular response to extracellular stimulusGO:003166820.022
vasculature developmentGO:00019442780.022
symbiosis encompassing mutualism through parasitismGO:004440340.021
biosynthetic processGO:00090582940.021
Yeast
positive regulation of secretionGO:005104710.021
ubiquitin dependent protein catabolic processGO:000651130.021
cellular nitrogen compound biosynthetic processGO:00442712180.021
determination of bilateral symmetryGO:00098552040.021
response to stressGO:00069502630.021
determination of left right symmetryGO:00073681790.021
neurotransmitter transportGO:000683620.021
regulation of metal ion transportGO:001095940.021
regulation of intracellular protein transportGO:003315730.021
nuclear transportGO:005116940.021
neurotransmitter secretionGO:000726920.021
cell projection organizationGO:00300302840.020
cellular component movementGO:00069283350.020
organic cyclic compound metabolic processGO:19013603010.020
Yeast
positive regulation of secretion by cellGO:190353210.020
cellular lipid catabolic processGO:004424230.020
synaptic vesicle transportGO:004848910.020
cytokinesisGO:000091030.020
rna metabolic processGO:00160702190.020
cellular response to nutrient levelsGO:003166920.020
protein targeting to nucleusGO:004474430.020
hormone transportGO:000991420.020
developmental growthGO:00485891660.020
negative regulation of biological processGO:00485193040.020
regulation of cellular amino acid metabolic processGO:000652100.020
exocytosisGO:000688710.020
organic acid metabolic processGO:0006082310.020
regulation of cellular ketone metabolic processGO:001056570.020
mitochondrion organizationGO:000700540.020
modification dependent macromolecule catabolic processGO:004363230.020
hormone secretionGO:004687920.020
single organism metabolic processGO:00447102170.020
Yeast
regulation of protein targetingGO:190353320.020
regulation of cellular biosynthetic processGO:00313262450.019
peptide transportGO:001583310.019
single organism nuclear importGO:190259330.019
synaptic vesicle localizationGO:009747910.019
regulation of bindingGO:005109830.019
cellular protein catabolic processGO:004425740.019
cell motilityGO:00488702440.019
proteolysis involved in cellular protein catabolic processGO:005160330.019
maternal determination of anterior posterior axis embryoGO:000835840.019
growthGO:00400071740.019
cell surface receptor signaling pathwayGO:00071663250.019
single fertilizationGO:000733830.019
cellular ketone metabolic processGO:0042180110.019
spermatid differentiationGO:004851520.019
glucose homeostasisGO:004259310.019
cellular biosynthetic processGO:00442492860.019
Yeast
neuroblast proliferationGO:000740520.019
negative regulation of protein phosphorylationGO:000193340.019
response to amino acidGO:004320020.018
protein metabolic processGO:00195381830.018
rna localizationGO:000640340.018
response to carbohydrateGO:000974330.018
regulation of protein complex assemblyGO:004325430.018
regulation of protein import into nucleusGO:004230620.018
phagocytosis engulfmentGO:000691110.018
positive regulation of cytokine productionGO:000181920.018
chemosensory behaviorGO:000763510.018
multi organism cellular processGO:004476420.018
membrane fusionGO:006102520.018
interspecies interaction between organismsGO:004441940.018
tissue remodelingGO:004877140.018
oxoacid metabolic processGO:0043436310.018
cellular component morphogenesisGO:00329893360.018
establishment of protein localization to plasma membraneGO:009000210.018
gtp catabolic processGO:000618420.018
cellular response to starvationGO:000926710.018
blood vessel developmentGO:00015682460.018
organic substance biosynthetic processGO:19015762890.018
Yeast
circulatory system processGO:0003013870.018
response to monosaccharideGO:003428430.018
heterocycle metabolic processGO:00464832900.017
blood circulationGO:0008015870.017
carboxylic acid metabolic processGO:0019752220.017
cellular response to biotic stimulusGO:007121630.017
regulation of nitrogen compound metabolic processGO:00511712510.017
cellular aromatic compound metabolic processGO:00067252950.017
eye developmentGO:00016542770.017
endosomal transportGO:001619720.017
regulation of neuronal synaptic plasticityGO:004816810.017
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.017
localization of cellGO:00516742440.017
alcohol biosynthetic processGO:004616520.017
Yeast
nucleobase containing compound metabolic processGO:00061392740.017
regulation of protein localization to nucleusGO:190018020.017
cell migrationGO:00164772370.017
carbohydrate homeostasisGO:003350010.017
tube morphogenesisGO:00352393490.017
organonitrogen compound metabolic processGO:1901564740.017
positive regulation of blood circulationGO:190352420.017
single organism membrane fusionGO:004480120.017
neurological system processGO:0050877620.017
protein importGO:001703830.017
sensory organ morphogenesisGO:00905962000.017
regulation of meiotic cell cycleGO:005144510.017
regulation of cell communicationGO:00106462320.017
cytoskeleton dependent cytokinesisGO:006164030.017
response to glucoseGO:000974930.017
endocrine hormone secretionGO:006098620.017
organelle organizationGO:00069962270.017
membrane invaginationGO:001032410.017
skeletal system developmentGO:00015011810.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
cytoplasm organizationGO:000702840.017
regulation of signalingGO:00230512350.017
macromolecule biosynthetic processGO:00090592270.017
single organism transportGO:00447652060.017
regulation of nucleoside metabolic processGO:000911820.016
proteasomal protein catabolic processGO:001049820.016
regulation of purine nucleotide catabolic processGO:003312120.016
negative regulation of protein kinase activityGO:000646940.016
regulation of neurotransmitter secretionGO:004692810.016
regulation of mrna processingGO:005068430.016
regulation of developmental processGO:00507932470.016
secondary metabolic processGO:001974830.016
oocyte anterior posterior axis specificationGO:000731440.016
cell substrate adhesionGO:003158940.016
fertilizationGO:000956630.016
negative regulation of cytoplasmic transportGO:190365020.016
regulation of neurotransmitter transportGO:005158810.016
protein stabilizationGO:005082120.016
positive regulation of cellular amine metabolic processGO:003324000.016
compound eye developmentGO:004874920.016
cellular component biogenesisGO:00440851780.016
i kappab kinase nf kappab signalingGO:000724940.016
morphogenesis of an epitheliumGO:00020093330.016
regulation of hormone secretionGO:004688320.016
response to alkaloidGO:004327920.015
purine nucleoside monophosphate catabolic processGO:000912840.015
response to amineGO:001407510.015
carboxylic acid catabolic processGO:004639530.015
angiogenesisGO:00015251580.015
neuromuscular process controlling balanceGO:005088530.015
intracellular mrna localizationGO:000829810.015
organelle fusionGO:004828430.015
production of molecular mediator of immune responseGO:000244020.015
positive regulation of purine nucleotide catabolic processGO:003312310.015
endocrine processGO:005088620.015
central nervous system developmentGO:00074173870.015
establishment of synaptic vesicle localizationGO:009748010.015
modification dependent protein catabolic processGO:001994130.015
response to hexoseGO:000974630.015
negative regulation of kinase activityGO:003367340.015
neuron developmentGO:00486662620.015
regulation of macromolecule metabolic processGO:00602553170.015
digestive tract developmentGO:00485652650.015
blood vessel morphogenesisGO:00485142160.015
mechanosensory behaviorGO:000763820.015
cellular response to chemical stimulusGO:00708871570.015
nucleobase containing compound biosynthetic processGO:00346542050.015
cellular component assemblyGO:00226071700.015
transmembrane transportGO:00550851200.014
adherens junction organizationGO:003433240.014
macromolecular complex disassemblyGO:003298410.014
regulation of gtpase activityGO:004308720.014
protein polymerizationGO:005125840.014
small molecule catabolic processGO:004428230.014
carbohydrate biosynthetic processGO:001605110.014
meiotic chromosome segregationGO:004513230.014
protein acetylationGO:000647320.014
regulation of gtp catabolic processGO:003312420.014
positive regulation of nucleoside metabolic processGO:004597910.014
regulation of reactive oxygen species metabolic processGO:200037720.014
internal peptidyl lysine acetylationGO:001839320.014
peptidyl lysine acetylationGO:001839420.014
lateral inhibitionGO:004633110.014
striated muscle cell developmentGO:00550021080.014
aromatic compound biosynthetic processGO:00194382170.014
transcription dna templatedGO:00063511810.014
regulation of primary metabolic processGO:00800903110.014
response to organic substanceGO:00100331530.014
single organism organelle organizationGO:19025891990.014
organic cyclic compound biosynthetic processGO:19013622230.014
Yeast
positive regulation of cell divisionGO:005178120.014
regulation of cell projection assemblyGO:006049140.014
sequestering of calcium ionGO:005120830.014
positive regulation of cellular amino acid metabolic processGO:004576400.014
regulation of inflammatory responseGO:005072720.014
neuromuscular synaptic transmissionGO:000727420.014
actin polymerization or depolymerizationGO:000815420.013
regulation of gene expressionGO:00104682650.013
regulation of nucleotide catabolic processGO:003081120.013
lipid catabolic processGO:001604240.013
positive regulation of nucleotide catabolic processGO:003081310.013
regulation of protein modification by small protein conjugation or removalGO:190332030.013
cellular amino acid metabolic processGO:000652070.013
negative regulation of protein serine threonine kinase activityGO:007190120.013
protein complex disassemblyGO:004324110.013
heterocycle biosynthetic processGO:00181302150.013
negative regulation of mapk cascadeGO:004340940.013
response to hydrogen peroxideGO:004254230.013
liver developmentGO:0001889960.013
actin filament based movementGO:003004810.013
pole plasm assemblyGO:000731540.013
cellular carbohydrate metabolic processGO:004426240.013
regulation of systemic arterial blood pressureGO:000307310.013
regulation of neural precursor cell proliferationGO:200017730.013
cartilage developmentGO:0051216960.013
regulation of transporter activityGO:003240920.013
antimicrobial humoral responseGO:001973020.013
brain developmentGO:00074202930.013
sequestering of metal ionGO:005123830.013
response to abiotic stimulusGO:00096281220.013
cellular response to oxygen levelsGO:007145310.013
protein secretionGO:000930610.013
negative regulation of sequestering of calcium ionGO:005128340.013
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.013
regulation of biosynthetic processGO:00098892500.013
cellular response to lipopolysaccharideGO:007122230.013
neuron neuron synaptic transmissionGO:000727010.013
regulation of dendrite developmentGO:005077330.013
regulation of peptidyl tyrosine phosphorylationGO:005073010.013
specification of symmetryGO:00097992040.013
response to uvGO:000941130.013
organelle assemblyGO:00709251100.013
embryo development ending in birth or egg hatchingGO:00097922710.013
regionalizationGO:00030022740.013
spermatid developmentGO:000728620.012
regulation of sequestering of calcium ionGO:005128240.012
cellular response to molecule of bacterial originGO:007121930.012
nucleic acid metabolic processGO:00903042440.012
negative regulation of protein transportGO:005122430.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.012
locomotor rhythmGO:004547530.012
regulation of cell shapeGO:000836010.012
positive regulation of gtp catabolic processGO:003312610.012
regulation of sodium ion transportGO:000202820.012
negative regulation of catabolic processGO:000989530.012
rna biosynthetic processGO:00327741810.012
protein acylationGO:004354330.012
regulation of cell activationGO:005086510.012
regulation of autophagyGO:001050630.012
g protein coupled receptor signaling pathwayGO:0007186740.012
response to other organismGO:0051707970.012
epithelial tube morphogenesisGO:00605621480.012
positive regulation of synapse assemblyGO:005196510.012
post embryonic morphogenesisGO:000988640.012
regulation of calcium ion transportGO:005192420.012
connective tissue developmentGO:0061448990.012
regulation of signal transductionGO:00099662250.012
positive regulation of gtpase activityGO:004354710.012
ribonucleoside monophosphate catabolic processGO:000915840.012
cellular localizationGO:0051641970.012
regulation of carbohydrate metabolic processGO:000610940.012
regulation of ion transmembrane transporter activityGO:003241220.012
calcium ion importGO:007050940.012
internal protein amino acid acetylationGO:000647520.012
negative regulation of protein complex assemblyGO:003133310.012
atp catabolic processGO:000620040.012
positive regulation of biological processGO:00485182530.012
regulation of endocrine processGO:004406020.012
positive regulation of epithelial cell proliferationGO:005067910.012
positive regulation of immune effector processGO:000269930.012
regulation of cellular metabolic processGO:00313233200.012
transcription from rna polymerase ii promoterGO:0006366800.012
regulation of protein polymerizationGO:003227120.012
response to corticosteroidGO:003196010.012
negative regulation of map kinase activityGO:004340720.012
digestive system developmentGO:00551232890.012
regulation of protein catabolic processGO:004217610.012
synaptic transmission cholinergicGO:000727140.012
stem cell divisionGO:001714510.012
nucleic acid templated transcriptionGO:00976591810.012
response to foodGO:003209410.012
generation of neuronsGO:00486993850.012
ion transportGO:00068111140.012
nucleoside monophosphate catabolic processGO:000912540.012
cellular amide metabolic processGO:004360340.012
cellular component disassemblyGO:002241110.012
actin filament polymerizationGO:003004120.012
mitochondrial transportGO:000683920.012
post embryonic organ developmentGO:004856940.012
multicellular organismal metabolic processGO:004423620.012
immune system processGO:00023762410.012
gland developmentGO:00487321430.011
positive regulation of apoptotic signaling pathwayGO:200123510.011
extrinsic apoptotic signaling pathwayGO:009719130.011
skeletal system morphogenesisGO:00487051020.011
cellular protein metabolic processGO:00442671290.011
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.011
smooth muscle contractionGO:000693920.011
homeostatic processGO:00425921420.011
positive regulation of cytoskeleton organizationGO:005149530.011
regulation of localizationGO:00328791040.011
anion transportGO:0006820380.011
vacuolar transportGO:000703420.011
cellular response to hypoxiaGO:007145610.011
embryonic skeletal system morphogenesisGO:0048704930.011
regulation of i kappab kinase nf kappab signalingGO:004312240.011
digestive tract morphogenesisGO:00485462310.011
g1 s transition of mitotic cell cycleGO:000008210.011
peptidyl threonine phosphorylationGO:001810710.011
sensory perception of smellGO:000760820.011
regulation of rna biosynthetic processGO:20011412130.011
regulation of macromolecule biosynthetic processGO:00105562250.011
peptide metabolic processGO:000651810.011
negative regulation of intracellular protein transportGO:009031730.011
negative regulation of cellular processGO:00485232830.011
ion transmembrane transportGO:0034220910.011
hepaticobiliary system developmentGO:0061008980.011
multicellular organismal response to stressGO:003355520.011
somatic muscle developmentGO:000752540.011
response to amphetamineGO:000197510.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
regulation of stem cell proliferationGO:007209120.011
cellular macromolecule biosynthetic processGO:00346452240.011
steroid hormone secretionGO:003592910.011
calcium mediated signalingGO:001972220.011
phosphatidylinositol mediated signalingGO:004801520.011
regulation of cellular carbohydrate metabolic processGO:001067540.011
negative regulation of protein import into nucleusGO:004230820.011
muscle structure developmentGO:00610611960.011
regulation of protein ubiquitinationGO:003139630.011
negative regulation of protein localization to nucleusGO:190018120.011
eye morphogenesisGO:00485921440.011
cell morphogenesisGO:00009022890.011
phosphatidylinositol 3 kinase signalingGO:001406520.011
determination of heart left right asymmetryGO:00613711170.011
negative regulation of multi organism processGO:004390130.011
negative regulation of reproductive processGO:200024230.011
convergent extensionGO:00600261180.011
viral processGO:001603210.011
response to topologically incorrect proteinGO:003596620.011
heart loopingGO:0001947940.011
regulation of epithelial cell proliferationGO:005067830.011
protein heterooligomerizationGO:005129110.011
regulation of dendrite morphogenesisGO:004881430.011
nuclear migrationGO:000709730.011
heart morphogenesisGO:00030071560.011
embryonic heart tube developmentGO:00350501330.011
organic acid catabolic processGO:001605430.011
negative regulation of intracellular transportGO:003238730.011
cell projection morphogenesisGO:00488582440.011
b cell activationGO:004211320.011
head developmentGO:00603223030.011
cellular response to organic substanceGO:00713101050.011
regulation of cellular macromolecule biosynthetic processGO:20001122220.011
positive regulation of dna metabolic processGO:005105410.011
cellular component assembly involved in morphogenesisGO:00109271070.011
cell matrix adhesionGO:000716040.011
xenobiotic metabolic processGO:000680540.011
inositol lipid mediated signalingGO:004801720.011
negative regulation of defense responseGO:003134820.010
cellular response to decreased oxygen levelsGO:003629410.010
regulation of rna metabolic processGO:00512522240.010
muscle cell differentiationGO:00426921390.010
gastrulationGO:00073692080.010
mononuclear cell proliferationGO:003294310.010
embryonic heart tube morphogenesisGO:00031431080.010
cytokinetic processGO:003250620.010
protein dephosphorylationGO:000647030.010
striated muscle cell differentiationGO:00511461290.010
post golgi vesicle mediated transportGO:000689210.010
positive regulation of protein complex assemblyGO:003133420.010
convergent extension involved in gastrulationGO:0060027710.010
positive regulation of cellular processGO:00485222010.010
hemopoiesisGO:00300971830.010
regulation of response to extracellular stimulusGO:003210410.010
embryonic skeletal system developmentGO:0048706970.010
neuron differentiationGO:00301823530.010
heart contractionGO:0060047710.010
multicellular organismal macromolecule metabolic processGO:004425920.010
monocarboxylic acid catabolic processGO:007232930.010
regulation of transcription dna templatedGO:00063552130.010
cell part morphogenesisGO:00329902460.010
lymphocyte proliferationGO:004665110.010
apoptotic processGO:00069151160.010
regulation of production of molecular mediator of immune responseGO:000270010.010
muscle cell developmentGO:00550011150.010
female gonad developmentGO:000858540.010

hmgcra disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.033
nervous system diseaseDOID:86300.019
disease of metabolismDOID:001466700.017
inherited metabolic disorderDOID:65500.014
disease of cellular proliferationDOID:1456600.013
cancerDOID:16200.013
organ system cancerDOID:005068600.013
cardiovascular system diseaseDOID:128700.012
musculoskeletal system diseaseDOID:1700.011