Danio rerio

16 known processes

pcsk9

proprotein convertase subtilisin/kexin type 9

pcsk9 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
embryonic organ developmentGO:00485683810.570
peptide metabolic processGO:000651810.527
regulation of gene expressionGO:00104682650.447
cartilage morphogenesisGO:0060536130.433
sensory system developmentGO:0048880760.426
neuromast developmentGO:0048884460.422
immunoglobulin mediated immune responseGO:001606430.398
lateral line system developmentGO:0048925760.396
appendage morphogenesisGO:0035107560.387
sensory organ developmentGO:00074233930.335
mechanosensory lateral line system developmentGO:0048881490.289
fin morphogenesisGO:0033334530.264
connective tissue developmentGO:0061448990.262
embryo development ending in birth or egg hatchingGO:00097922710.241
cellular amide metabolic processGO:004360340.239
fin developmentGO:0033333770.234
cellular nitrogen compound metabolic processGO:00346412900.234
cartilage developmentGO:0051216960.227
chordate embryonic developmentGO:00430092710.219
embryonic skeletal system morphogenesisGO:0048704930.216
embryonic cranial skeleton morphogenesisGO:0048701900.202
embryonic skeletal system developmentGO:0048706970.190
skeletal system morphogenesisGO:00487051020.181
nucleic acid templated transcriptionGO:00976591810.171
cellular biosynthetic processGO:00442492860.169
aromatic compound biosynthetic processGO:00194382170.161
regulation of biosynthetic processGO:00098892500.160
biosynthetic processGO:00090582940.158
appendage developmentGO:0048736800.156
regulation of transcription dna templatedGO:00063552130.156
embryonic viscerocranium morphogenesisGO:0048703520.153
regulation of nucleic acid templated transcriptionGO:19035062130.147
protein processingGO:0016485120.145
eye developmentGO:00016542770.144
urogenital system developmentGO:0001655970.139
embryonic organ morphogenesisGO:00485622740.135
nucleobase containing compound metabolic processGO:00061392740.133
regulation of rna biosynthetic processGO:20011412130.129
cellular nitrogen compound biosynthetic processGO:00442712180.128
gene expressionGO:00104672520.126
lateral line developmentGO:0048882660.124
negative regulation of reproductive processGO:200024230.115
rna biosynthetic processGO:00327741810.113
regulation of nucleobase containing compound metabolic processGO:00192192500.111
agingGO:000756820.102
regulation of metabolic processGO:00192223590.101
rna metabolic processGO:00160702190.098
organic cyclic compound biosynthetic processGO:19013622230.097
protein metabolic processGO:00195381830.094
inner ear developmentGO:00488391260.093
carbohydrate homeostasisGO:003350010.091
regulation of rna metabolic processGO:00512522240.091
regulation of fatty acid metabolic processGO:001921710.091
cell motilityGO:00488702440.088
organic substance biosynthetic processGO:19015762890.085
regulation of biological qualityGO:00650082630.083
localization of cellGO:00516742440.083
hormone metabolic processGO:0042445190.082
regulation of cellular biosynthetic processGO:00313262450.081
water homeostasisGO:003010440.079
innate immune responseGO:0045087130.079
regulation of nitrogen compound metabolic processGO:00511712510.076
female sex differentiationGO:004666040.076
cellular macromolecule metabolic processGO:00442603910.075
nitrogen compound metabolic processGO:00068073190.074
complement activation classical pathwayGO:000695830.074
response to drugGO:004249330.072
heterocycle metabolic processGO:00464832900.072
transcription dna templatedGO:00063511810.071
regulation of cellular macromolecule biosynthetic processGO:20001122220.071
heterocycle biosynthetic processGO:00181302150.069
establishment of localizationGO:00512342440.068
complement activationGO:000695630.067
organonitrogen compound metabolic processGO:1901564740.067
positive regulation of nucleic acid templated transcriptionGO:1903508570.066
negative regulation of nucleic acid templated transcriptionGO:1903507450.064
skeletal system developmentGO:00015011810.063
female gonad developmentGO:000858540.062
amide biosynthetic processGO:004360410.062
regulation of primary metabolic processGO:00800903110.061
multi organism cellular processGO:004476420.061
regulation of defense responseGO:0031347140.061
regulation of locomotionGO:0040012550.061
transportGO:00068102200.059
regulation of reproductive processGO:200024140.059
brain developmentGO:00074202930.059
locomotionGO:00400113130.058
negative regulation of biological processGO:00485193040.057
protein heterooligomerizationGO:005129110.057
anterior lateral line developmentGO:004889950.056
regulation of transcription from rna polymerase ii promoterGO:00063571140.056
symbiosis encompassing mutualism through parasitismGO:004440340.054
organic cyclic compound metabolic processGO:19013603010.052
nucleobase containing compound biosynthetic processGO:00346542050.052
muscle fiber developmentGO:0048747520.051
androgen metabolic processGO:000820920.051
transcription from rna polymerase ii promoterGO:0006366800.051
anterior lateral line system developmentGO:004889890.050
natural killer cell mediated cytotoxicityGO:004226710.050
synaptic target recognitionGO:000803910.050
regulation of response to stimulusGO:00485832690.049
macromolecule biosynthetic processGO:00090592270.047
regulation of hormone secretionGO:004688320.046
regulation of cytoplasmic transportGO:190364940.045
signal transductionGO:00071654550.045
positive regulation of cytokine productionGO:000181920.043
nuclear transportGO:005116940.043
regulation of i kappab kinase nf kappab signalingGO:004312240.043
blood vessel developmentGO:00015682460.043
regulation of natural killer cell mediated immunityGO:000271510.043
protein activation cascadeGO:007237660.043
positive regulation of biosynthetic processGO:0009891680.043
positive regulation of immune effector processGO:000269930.042
regulation of cellular ketone metabolic processGO:001056570.041
positive regulation of transportGO:005105020.041
regulation of cytokine productionGO:000181730.040
epithelial cell differentiationGO:00308551160.040
regulation of ion transmembrane transporter activityGO:003241220.040
cell migrationGO:00164772370.040
cellular macromolecule biosynthetic processGO:00346452240.040
negative regulation of programmed cell deathGO:0043069580.039
regulation of glucose importGO:004632410.039
negative regulation of peptidase activityGO:0010466100.038
cellular aromatic compound metabolic processGO:00067252950.038
negative regulation of rna metabolic processGO:0051253480.038
regulation of macromolecule metabolic processGO:00602553170.037
calcium ion importGO:007050940.037
negative regulation of gene expressionGO:0010629650.037
positive regulation of nitrogen compound metabolic processGO:0051173690.036
membrane lipid biosynthetic processGO:004646720.036
defense responseGO:0006952470.036
anterior posterior pattern specificationGO:00099521520.036
renal absorptionGO:007029310.036
regulation of signal transductionGO:00099662250.036
protein localization to nucleusGO:003450430.035
glucose homeostasisGO:004259310.035
positive regulation of innate immune responseGO:004508980.035
retina development in camera type eyeGO:00600411460.035
regulation of macromolecule biosynthetic processGO:00105562250.035
positive regulation of rna metabolic processGO:0051254590.035
response to external biotic stimulusGO:0043207970.033
regulation of stem cell differentiationGO:200073640.032
kidney developmentGO:0001822920.032
cellular component movementGO:00069283350.032
single organism localizationGO:19025782250.032
regulation of cellular metabolic processGO:00313233200.032
regulation of hormone levelsGO:0010817210.032
regulation of developmental processGO:00507932470.032
single organism metabolic processGO:00447102170.031
regulation of multicellular organismal developmentGO:20000262230.031
hatchingGO:003518840.031
regulation of signalingGO:00230512350.031
negative regulation of behaviorGO:004852160.031
cell fate specificationGO:0001708680.030
production of molecular mediator of immune responseGO:000244020.030
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.030
nucleic acid metabolic processGO:00903042440.030
humoral immune response mediated by circulating immunoglobulinGO:000245530.030
regulation of protein import into nucleusGO:004230620.030
regulation of production of molecular mediator of immune responseGO:000270010.029
regulation of protein complex assemblyGO:004325430.029
positive regulation of nucleobase containing compound metabolic processGO:0045935690.029
notochord developmentGO:0030903540.029
negative regulation of mapk cascadeGO:004340940.029
ameboidal type cell migrationGO:00016671430.029
regulation of cellular carbohydrate metabolic processGO:001067540.028
lipid storageGO:001991510.028
negative regulation of macromolecule metabolic processGO:0010605760.028
nik nf kappab signalingGO:003806110.028
homeostatic processGO:00425921420.028
positive regulation of leukocyte mediated cytotoxicityGO:000191210.028
establishment of protein localization to organelleGO:007259440.027
carboxylic acid catabolic processGO:004639530.027
regulation of inflammatory responseGO:005072720.027
myelin assemblyGO:003228810.027
negative regulation of defense responseGO:003134820.027
cranial ganglion developmentGO:006155030.027
positive regulation of cell divisionGO:005178120.026
cellular protein modification processGO:00064641000.026
positive regulation of macromolecule metabolic processGO:0010604930.026
positive regulation of gene expressionGO:0010628710.026
cell surface receptor signaling pathwayGO:00071663250.026
gastrulationGO:00073692080.026
positive regulation of lymphocyte mediated immunityGO:000270810.026
response to external stimulusGO:00096052640.025
regulation of stem cell proliferationGO:007209120.025
single organism transportGO:00447652060.025
regulation of translational initiationGO:000644610.025
cellular component morphogenesisGO:00329893360.025
maintenance of locationGO:005123540.025
interspecies interaction between organismsGO:004441940.025
regulation of protein bindingGO:004339330.025
regulation of multicellular organismal processGO:00512392770.025
protein maturationGO:0051604120.024
regulation of leukocyte mediated immunityGO:000270310.024
proteolysisGO:0006508380.024
head developmentGO:00603223030.024
larval developmentGO:000216420.024
regulation of peptidase activityGO:0052547230.024
otolith developmentGO:0048840320.024
regulation of endopeptidase activityGO:0052548230.024
regionalizationGO:00030022740.024
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.024
morphogenesis of an epitheliumGO:00020093330.024
carboxylic acid metabolic processGO:0019752220.024
deathGO:00162651210.024
development of primary female sexual characteristicsGO:004654540.024
cellular amine metabolic processGO:004410620.023
regulation of response to biotic stimulusGO:000283120.023
ear developmentGO:00435831270.023
cell deathGO:00082191210.023
phagocytosisGO:000690930.023
lipid oxidationGO:003444010.022
multi organism processGO:00517041340.022
monocarboxylic acid catabolic processGO:007232930.022
somitogenesisGO:0001756870.022
response to other organismGO:0051707970.022
regulation of cellular amino acid metabolic processGO:000652100.022
immune system processGO:00023762410.022
phosphorus metabolic processGO:00067931090.022
determination of bilateral symmetryGO:00098552040.022
glucose importGO:004632320.021
regulation of bindingGO:005109830.021
negative regulation of cytokine productionGO:000181810.021
calcium mediated signalingGO:001972220.021
hormone transportGO:000991420.021
protein targeting to nucleusGO:004474430.021
ion transmembrane transportGO:0034220910.020
eye morphogenesisGO:00485921440.020
organic substance transportGO:0071702580.020
organonitrogen compound biosynthetic processGO:1901566470.020
lymph vessel morphogenesisGO:0036303250.020
protein secretionGO:000930610.020
b cell activationGO:004211320.020
wnt signaling pathwayGO:0016055800.020
negative regulation of hormone secretionGO:004688820.019
regulation of molecular functionGO:0065009700.019
somite developmentGO:0061053960.019
negative regulation of cellular processGO:00485232830.019
ovulation cycle processGO:002260220.019
nephric duct developmentGO:0072176130.019
positive regulation of leukocyte mediated immunityGO:000270510.019
regulation of establishment of protein localizationGO:007020140.019
lymph vessel developmentGO:0001945270.019
hormone biosynthetic processGO:004244630.019
positive regulation of biological processGO:00485182530.019
neuron developmentGO:00486662620.019
regulation of transferase activityGO:0051338160.019
regulation of protein transportGO:005122330.019
liver developmentGO:0001889960.019
positive regulation of glucose transportGO:001082810.018
hepaticobiliary system developmentGO:0061008980.018
positive regulation of cellular metabolic processGO:0031325940.018
negative regulation of transcription dna templatedGO:0045892450.018
immunoglobulin productionGO:000237710.018
dorsal ventral pattern formationGO:00099531250.018
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.018
regulation of cell deathGO:00109411030.018
organic acid catabolic processGO:001605430.018
membrane invaginationGO:001032410.018
positive regulation of cellular amine metabolic processGO:003324000.018
cellular protein metabolic processGO:00442671290.018
regulation of protein targetingGO:190353320.018
regulation of system processGO:0044057400.018
somatic muscle developmentGO:000752540.017
pectoral fin morphogenesisGO:0035138290.017
neuron differentiationGO:00301823530.017
epithelial cell developmentGO:0002064420.017
programmed cell deathGO:00125011190.017
negative regulation of macromolecule biosynthetic processGO:0010558480.017
negative regulation of protein phosphorylationGO:000193340.017
immune effector processGO:0002252230.017
ovulation cycleGO:004269820.017
antimicrobial humoral responseGO:001973020.016
response to bacteriumGO:0009617580.016
negative regulation of cell communicationGO:0010648960.016
endocrine processGO:005088620.016
positive regulation of rna biosynthetic processGO:1902680570.016
hemopoiesisGO:00300971830.016
regulation of peptidyl tyrosine phosphorylationGO:005073010.016
single organism nuclear importGO:190259330.016
regulation of nucleocytoplasmic transportGO:004682220.016
determination of left right symmetryGO:00073681790.016
cellular lipid catabolic processGO:004424230.016
regulation of intracellular protein transportGO:003315730.016
pronephros developmentGO:0048793690.016
regulation of cellular amine metabolic processGO:003323800.016
negative regulation of kinase activityGO:003367340.015
nucleocytoplasmic transportGO:000691340.015
positive regulation of secretionGO:005104710.015
stem cell proliferationGO:007208940.015
nuclear importGO:005117030.015
regulation of lymphocyte mediated immunityGO:000270610.015
response to monosaccharideGO:003428430.015
i kappab kinase nf kappab signalingGO:000724940.015
organelle organizationGO:00069962270.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
hindbrain developmentGO:0030902910.015
viral processGO:001603210.015
regulation of calcium ion transportGO:005192420.015
regulation of immune system processGO:0002682340.015
lipid metabolic processGO:0006629520.015
regulation of carbohydrate metabolic processGO:000610940.015
regulation of metal ion transportGO:001095940.015
stem cell maintenanceGO:001982740.015
mesenchyme developmentGO:00604851270.015
regulation of protein ubiquitinationGO:003139630.015
nephron developmentGO:0072006310.014
positive regulation of cell activationGO:005086710.014
camera type eye developmentGO:00430102220.014
macromolecule modificationGO:00434121110.014
cell killingGO:000190620.014
larval behaviorGO:003053750.014
cellular response to organic substanceGO:00713101050.014
negative regulation of metabolic processGO:0009892860.014
regulation of epithelial cell proliferationGO:005067830.014
regulation of cell communicationGO:00106462320.014
retina morphogenesis in camera type eyeGO:0060042790.014
regulation of chronic inflammatory responseGO:000267610.014
phagocytosis engulfmentGO:000691110.014
negative regulation of protein kinase activityGO:000646940.014
cellular carbohydrate metabolic processGO:004426240.014
eye photoreceptor cell developmentGO:0042462300.014
negative regulation of sequestering of calcium ionGO:005128340.014
lipid catabolic processGO:001604240.014
cellular response to molecule of bacterial originGO:007121930.014
adult behaviorGO:003053420.014
multicellular organismal macromolecule metabolic processGO:004425920.014
system processGO:00030081850.013
negative regulation of translationGO:001714810.013
cellular component biogenesisGO:00440851780.013
positive regulation of defense responseGO:003134990.013
negative regulation of hydrolase activityGO:0051346100.013
response to glucoseGO:000974930.013
blood vessel morphogenesisGO:00485142160.013
vasculature developmentGO:00019442780.013
negative regulation of cellular biosynthetic processGO:0031327550.013
kidney epithelium developmentGO:0072073230.013
positive regulation of cell cycleGO:004578730.013
wound healingGO:0042060900.013
cellular component assemblyGO:00226071700.013
mitotic cell cycleGO:0000278640.013
negative regulation of protein transportGO:005122430.013
androgen biosynthetic processGO:000670210.013
small molecule metabolic processGO:0044281770.013
multicellular organism growthGO:003526440.013
regulation of protein processingGO:0070613100.013
hormone secretionGO:004687920.013
negative regulation of cell deathGO:0060548600.013
protein modification processGO:00362111000.013
regulation of transportGO:0051049450.013
regulation of protein localization to nucleusGO:190018020.013
regulation of transporter activityGO:003240920.012
negative regulation of nitrogen compound metabolic processGO:0051172590.012
apoptotic processGO:00069151160.012
leukocyte mediated cytotoxicityGO:000190910.012
translational initiationGO:000641330.012
negative regulation of multi organism processGO:004390130.012
response to chemicalGO:00422213200.012
response to biotic stimulusGO:0009607970.012
neuronal action potentialGO:0019228180.012
fatty acid biosynthetic processGO:000663340.012
hematopoietic or lymphoid organ developmentGO:00485341910.012
protein acetylationGO:000647320.012
negative regulation of rna biosynthetic processGO:1902679450.012
cellular response to endogenous stimulusGO:0071495680.012
phosphate containing compound metabolic processGO:00067961080.012
regulation of cellular protein catabolic processGO:190336210.012
fatty acid transportGO:001590810.012
negative regulation of map kinase activityGO:004340720.012
negative regulation of proteolysisGO:0045861100.012
response to carbohydrateGO:000974330.012
negative regulation of nucleobase containing compound metabolic processGO:0045934590.012
cellular localizationGO:0051641970.012
digestive tract morphogenesisGO:00485462310.012
negative regulation of cellular metabolic processGO:0031324770.012
sex determinationGO:000753010.012
negative regulation of signal transductionGO:0009968940.012
sphingolipid biosynthetic processGO:003014820.012
cell migration involved in gastrulationGO:0042074790.012
positive regulation of cytosolic calcium ion concentrationGO:000720440.012
aorta developmentGO:003590440.012
internal protein amino acid acetylationGO:000647520.012
regulation of transmembrane transporter activityGO:002289820.012
regulation of innate immune responseGO:0045088110.012
lens fiber cell developmentGO:007030730.012
regulation of cell activationGO:005086510.011
negative regulation of protein serine threonine kinase activityGO:007190120.011
cell part morphogenesisGO:00329902460.011
regulation of skeletal muscle tissue developmentGO:004864140.011
small molecule catabolic processGO:004428230.011
negative regulation of nuclear divisionGO:005178430.011
regulation of cell migrationGO:0030334400.011
single organism organelle organizationGO:19025891990.011
regulation of synapse organizationGO:005080730.011
immune system developmentGO:00025201910.011
cellular ketone metabolic processGO:0042180110.011
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.011
regulation of phosphate metabolic processGO:0019220430.011
blood vessel endothelial cell migrationGO:0043534180.011
cellular response to chemical stimulusGO:00708871570.011
adherens junction organizationGO:003433240.011
positive regulation of cell substrate adhesionGO:001081110.011
plasminogen activationGO:003163930.011
angiogenesisGO:00015251580.011
protein importGO:001703830.011
epidermal cell fate specificationGO:000995740.011
axon ensheathment in central nervous systemGO:003229120.011
b cell mediated immunityGO:001972430.011
nephron epithelium developmentGO:0072009160.011
cellular response to biotic stimulusGO:007121630.011
meiosis iGO:000712710.011
glial cell proliferationGO:001400940.011
peptidyl lysine acetylationGO:001839420.011
positive regulation of blood circulationGO:190352420.011
fatty acid catabolic processGO:000906210.010
amine metabolic processGO:000930820.010
response to vitaminGO:003327330.010
regulation of endothelial cell proliferationGO:000193610.010
cognitionGO:005089010.010
positive regulation of i kappab kinase nf kappab signalingGO:004312330.010
positive regulation of metabolic processGO:00098931080.010
positive regulation of immune system processGO:0002684170.010
response to glucocorticoidGO:005138410.010
positive regulation of production of molecular mediator of immune responseGO:000270210.010
regulation of receptor activityGO:001046920.010
negative regulation of multicellular organismal processGO:0051241690.010
positive regulation of inflammatory responseGO:005072910.010
lateral line ganglion developmentGO:004889020.010
regulation of dna templated transcription in response to stressGO:004362000.010
mesoderm developmentGO:0007498880.010
myeloid cell differentiationGO:0030099860.010
lymphocyte mediated immunityGO:000244950.010
muscle organ developmentGO:00075171010.010
anion transportGO:0006820380.010

pcsk9 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.019
disease of metabolismDOID:001466700.015
musculoskeletal system diseaseDOID:1700.013
disease of cellular proliferationDOID:1456600.010
cancerDOID:16200.010