Danio rerio

36 known processes

prpf8

pre-mRNA processing factor 8

(Aliases: tdsubc_2a9,wu:fb37c02,zgc:56504,MGC56504,wu:fb73e06,id:ibd1257,ik:tdsubc_2a9,im:7141966,xx:tdsubc_2a9,MGC162871)

prpf8 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.793
Worm
gene expressionGO:00104672520.599
embryo development ending in birth or egg hatchingGO:00097922710.535
Worm
positive regulation of biological processGO:00485182530.500
regulation of macromolecule metabolic processGO:00602553170.385
organic substance biosynthetic processGO:19015762890.365
cellular component assemblyGO:00226071700.360
anterior posterior pattern specificationGO:00099521520.349
cellular aromatic compound metabolic processGO:00067252950.346
regionalizationGO:00030022740.341
nitrogen compound metabolic processGO:00068073190.336
embryonic organ morphogenesisGO:00485622740.321
meiotic nuclear divisionGO:000712640.317
cellular macromolecule metabolic processGO:00442603910.304
cellular macromolecule biosynthetic processGO:00346452240.302
cell projection organizationGO:00300302840.286
positive regulation of cellular processGO:00485222010.283
embryonic organ developmentGO:00485683810.282
regulation of mrna processingGO:005068430.281
cell morphogenesisGO:00009022890.273
cellular component biogenesisGO:00440851780.271
establishment of localizationGO:00512342440.270
Worm
cell projection morphogenesisGO:00488582440.264
cellular component morphogenesisGO:00329893360.261
rna metabolic processGO:00160702190.249
organic cyclic compound metabolic processGO:19013603010.249
chordate embryonic developmentGO:00430092710.249
transcription from rna polymerase ii promoterGO:0006366800.249
rna localizationGO:000640340.239
nuclear transportGO:005116940.236
nucleobase containing compound metabolic processGO:00061392740.236
regulation of cellular metabolic processGO:00313233200.235
biosynthetic processGO:00090582940.229
regulation of multicellular organismal processGO:00512392770.226
regulation of developmental processGO:00507932470.225
cell deathGO:00082191210.222
regulation of multicellular organismal developmentGO:20000262230.221
protein complex subunit organizationGO:0071822460.219
locomotionGO:00400113130.218
Worm
generation of neuronsGO:00486993850.214
digestive system developmentGO:00551232890.213
macromolecule biosynthetic processGO:00090592270.212
cellular nitrogen compound metabolic processGO:00346412900.211
organelle organizationGO:00069962270.210
regulation of gene expressionGO:00104682650.205
cellular component movementGO:00069283350.203
Worm
apoptotic processGO:00069151160.197
regulation of response to stimulusGO:00485832690.196
nucleocytoplasmic transportGO:000691340.189
nucleobase containing compound biosynthetic processGO:00346542050.182
heterocycle metabolic processGO:00464832900.178
rna export from nucleusGO:000640510.171
macromolecular complex subunit organizationGO:0043933740.171
cellular biosynthetic processGO:00442492860.170
nuclear exportGO:005116810.168
negative regulation of cellular processGO:00485232830.163
macromolecular complex assemblyGO:0065003350.161
organic cyclic compound biosynthetic processGO:19013622230.154
aromatic compound biosynthetic processGO:00194382170.149
negative regulation of biological processGO:00485193040.147
positive regulation of macromolecule metabolic processGO:0010604930.146
regulation of rna metabolic processGO:00512522240.143
cell migrationGO:00164772370.140
Worm
rna transportGO:005065820.136
cell part morphogenesisGO:00329902460.136
digestive tract morphogenesisGO:00485462310.134
heterocycle biosynthetic processGO:00181302150.133
mrna metabolic processGO:0016071200.130
stem cell developmentGO:0048864820.130
signal transductionGO:00071654550.127
digestive tract developmentGO:00485652650.123
symbiosis encompassing mutualism through parasitismGO:004440340.123
nucleoside monophosphate catabolic processGO:000912540.121
sensory organ developmentGO:00074233930.120
regulation of nucleobase containing compound metabolic processGO:00192192500.120
mesenchymal cell differentiationGO:0048762870.118
nucleic acid templated transcriptionGO:00976591810.116
multi organism cellular processGO:004476420.115
odontogenesis of dentin containing toothGO:004247510.114
immune system processGO:00023762410.113
muscle structure developmentGO:00610611960.112
positive regulation of nucleobase containing compound metabolic processGO:0045935690.110
hematopoietic or lymphoid organ developmentGO:00485341910.109
protein localization to nucleusGO:003450430.107
response to stressGO:00069502630.102
programmed cell deathGO:00125011190.102
axon developmentGO:00615641660.101
positive regulation of transportGO:005105020.101
regulation of anatomical structure morphogenesisGO:00226031300.100
single organism organelle organizationGO:19025891990.099
cellular response to chemical stimulusGO:00708871570.098
cell motilityGO:00488702440.097
Worm
striated muscle cell developmentGO:00550021080.096
negative regulation of ras protein signal transductionGO:004658010.096
cytoskeleton organizationGO:0007010960.096
developmental growthGO:00485891660.096
growthGO:00400071740.095
regulation of meiotic cell cycleGO:005144510.095
immune system developmentGO:00025201910.094
segmentationGO:0035282970.093
multicellular organism growthGO:003526440.093
regulation of nucleocytoplasmic transportGO:004682220.093
forebrain developmentGO:0030900960.092
regulation of macromolecule biosynthetic processGO:00105562250.092
deathGO:00162651210.092
mesenchyme developmentGO:00604851270.091
hemopoiesisGO:00300971830.091
nucleobase containing compound transportGO:001593120.090
neuron developmentGO:00486662620.090
striated muscle cell differentiationGO:00511461290.090
cell cycleGO:0007049930.090
regulation of apoptotic processGO:0042981980.088
ribonucleoprotein complex assemblyGO:002261850.087
neuron projection developmentGO:00311751800.086
rna splicing via transesterification reactions with bulged adenosine as nucleophileGO:0000377100.086
transcription dna templatedGO:00063511810.085
response to organic cyclic compoundGO:0014070510.085
regulation of biological qualityGO:00650082630.084
purine nucleoside monophosphate catabolic processGO:000912840.083
regulation of metabolic processGO:00192223590.083
homeostatic processGO:00425921420.082
protein complex assemblyGO:0006461300.081
single organism localizationGO:19025782250.081
negative regulation of metabolic processGO:0009892860.080
protein metabolic processGO:00195381830.080
cellular nitrogen compound biosynthetic processGO:00442712180.077
regulation of cell deathGO:00109411030.076
neuron differentiationGO:00301823530.076
organelle assemblyGO:00709251100.075
positive regulation of rna biosynthetic processGO:1902680570.075
regulation of signal transductionGO:00099662250.075
negative regulation of macromolecule metabolic processGO:0010605760.074
viral processGO:001603210.074
ribonucleoside monophosphate catabolic processGO:000915840.074
nucleic acid transportGO:005065720.073
positive regulation of cellular component biogenesisGO:004408930.073
agingGO:000756820.071
tube morphogenesisGO:00352393490.071
positive regulation of rna metabolic processGO:0051254590.070
reproductive processGO:0022414400.069
Worm
positive regulation of cellular metabolic processGO:0031325940.069
rna splicingGO:0008380160.069
embryonic skeletal system developmentGO:0048706970.068
camera type eye developmentGO:00430102220.068
synaptic growth at neuromuscular junctionGO:005112420.067
cellular component assembly involved in morphogenesisGO:00109271070.066
response to organic substanceGO:00100331530.066
protein import into nucleusGO:000660630.065
neuron projection morphogenesisGO:00488121610.065
response to biotic stimulusGO:0009607970.064
positive regulation of biosynthetic processGO:0009891680.064
microtubule cytoskeleton organizationGO:0000226330.063
positive regulation of gene expressionGO:0010628710.063
skeletal system developmentGO:00015011810.063
regulation of cell cycleGO:0051726520.063
negative regulation of developmental processGO:0051093650.062
cell morphogenesis involved in neuron differentiationGO:00486671630.061
pancreas developmentGO:0031016840.061
regulation of cytoplasmic transportGO:190364940.061
mitotic cell cycle processGO:1903047480.060
cell proliferationGO:0008283800.060
stem cell maintenanceGO:001982740.060
maintenance of locationGO:005123540.059
cell cycle processGO:0022402530.057
mrna processingGO:0006397140.057
regulation of glial cell differentiationGO:004568540.057
mrna splicing via spliceosomeGO:0000398100.057
nuclear divisionGO:0000280230.056
regulation of primary metabolic processGO:00800903110.056
blood vessel morphogenesisGO:00485142160.055
negative regulation of small gtpase mediated signal transductionGO:005105810.053
neural crest cell differentiationGO:0014033720.052
localization of cellGO:00516742440.052
Worm
lipid storageGO:001991510.051
protein targeting to nucleusGO:004474430.051
regulation of nitrogen compound metabolic processGO:00511712510.051
negative regulation of multicellular organismal processGO:0051241690.050
regulation of cell differentiationGO:00455951420.050
atp catabolic processGO:000620040.050
heart developmentGO:00075073130.050
cellular response to organic cyclic compoundGO:0071407380.050
response to chemicalGO:00422213200.050
ribonucleoprotein complex biogenesisGO:0022613130.050
positive regulation of metabolic processGO:00098931080.049
mitotic cell cycleGO:0000278640.049
regulation of transcription dna templatedGO:00063552130.049
cell morphogenesis involved in differentiationGO:00009041950.049
regulation of multicellular organism growthGO:004001440.049
central nervous system developmentGO:00074173870.048
pigmentationGO:0043473850.048
rna biosynthetic processGO:00327741810.048
nuclear importGO:005117030.047
vasculature developmentGO:00019442780.047
muscle cell developmentGO:00550011150.047
brain developmentGO:00074202930.047
response to unfolded proteinGO:000698620.046
homeostasis of number of cellsGO:0048872620.046
regulation of transcription from rna polymerase ii promoterGO:00063571140.045
gastrulationGO:00073692080.045
nucleic acid metabolic processGO:00903042440.044
interspecies interaction between organismsGO:004441940.044
cellular protein metabolic processGO:00442671290.044
embryonic cranial skeleton morphogenesisGO:0048701900.044
positive regulation of transcription dna templatedGO:0045893570.043
positive regulation of cellular catabolic processGO:003133130.043
morphogenesis of an epitheliumGO:00020093330.042
regulation of protein complex assemblyGO:004325430.042
negative regulation of gene expressionGO:0010629650.042
organic substance transportGO:0071702580.041
embryonic pattern specificationGO:0009880440.041
embryonic skeletal system morphogenesisGO:0048704930.041
meiotic cell cycle processGO:190304630.040
establishment of protein localization to organelleGO:007259440.040
cellular localizationGO:0051641970.040
mesenchymal cell developmentGO:0014031780.040
transportGO:00068102200.040
Worm
regulation of cysteine type endopeptidase activityGO:2000116210.039
system processGO:00030081850.039
negative regulation of protein phosphorylationGO:000193340.039
single organism transportGO:00447652060.038
positive regulation of nitrogen compound metabolic processGO:0051173690.038
neural crest cell developmentGO:0014032620.038
response to abiotic stimulusGO:00096281220.038
actin filament based processGO:0030029640.038
oocyte anterior posterior axis specificationGO:000731440.038
establishment of localization in cellGO:0051649770.038
modification of morphology or physiology of other organism involved in symbiotic interactionGO:005181740.037
endodermal cell differentiationGO:0035987190.037
regulation of synapse assemblyGO:005196330.037
regulation of cellular protein metabolic processGO:0032268520.037
cytokinesisGO:000091030.037
negative regulation of mrna metabolic processGO:190331230.037
establishment of rna localizationGO:005123630.037
convergent extensionGO:00600261180.037
negative regulation of synapse assemblyGO:005196420.036
purine ribonucleoside monophosphate catabolic processGO:000916940.036
transmembrane transportGO:00550851200.036
regulation of biosynthetic processGO:00098892500.036
mrna transportGO:005102820.036
small gtpase mediated signal transductionGO:000726480.036
blood vessel developmentGO:00015682460.036
muscle cell differentiationGO:00426921390.035
ras protein signal transductionGO:000726570.035
single organism nuclear importGO:190259330.035
stem cell differentiationGO:00488631170.035
regulation of cellular biosynthetic processGO:00313262450.035
intracellular signal transductionGO:0035556850.034
modification of morphology or physiology of other organismGO:003582140.034
negative regulation of transcription from rna polymerase ii promoterGO:0000122160.033
response to lipidGO:0033993600.033
cellular process involved in reproduction in multicellular organismGO:0022412280.032
regulation of cell shapeGO:000836010.032
single organism metabolic processGO:00447102170.032
eye developmentGO:00016542770.032
regulation of immune system processGO:0002682340.032
regulation of protein targetingGO:190353320.032
negative regulation of cellular metabolic processGO:0031324770.031
regulation of establishment of protein localizationGO:007020140.031
cation transmembrane transportGO:0098655650.031
cellular response to stressGO:0033554620.031
multi organism processGO:00517041340.031
mrna 3 end processingGO:003112420.031
mrna stabilizationGO:004825540.031
regulation of organelle organizationGO:0033043290.030
regulation of programmed cell deathGO:00430671010.030
regulation of protein transportGO:005122330.030
positive regulation of nucleic acid templated transcriptionGO:1903508570.030
nuclear pore organizationGO:000699920.029
gamete generationGO:0007276330.029
regulation of protein localization to nucleusGO:190018020.029
angiogenesisGO:00015251580.029
response to other organismGO:0051707970.029
myeloid cell differentiationGO:0030099860.029
positive regulation of catabolic processGO:000989640.028
developmental process involved in reproductionGO:0003006270.028
Worm
negative regulation of rna splicingGO:003311910.028
actin cytoskeleton organizationGO:0030036630.028
cellular macromolecular complex assemblyGO:0034622240.028
negative regulation of signal transductionGO:0009968940.028
rna 3 end processingGO:003112320.028
rna processingGO:0006396250.028
ribonucleoprotein complex subunit organizationGO:007182680.027
protein importGO:001703830.027
multicellular organismal reproductive processGO:0048609350.027
microtubule cytoskeleton organization involved in mitosisGO:190285010.027
protein complex biogenesisGO:0070271300.027
gene silencing by rnaGO:003104740.027
single organism cellular localizationGO:1902580460.027
positive regulation of response to stimulusGO:0048584800.027
regulation of stem cell differentiationGO:200073640.026
single organism reproductive processGO:0044702400.026
Worm
regulation of cell communicationGO:00106462320.026
small molecule metabolic processGO:0044281770.025
regulation of cell proliferationGO:0042127370.025
regulation of cellular component organizationGO:0051128860.025
epithelial cell differentiationGO:00308551160.025
negative regulation of cell differentiationGO:0045596460.025
cellular protein modification processGO:00064641000.025
endoderm developmentGO:0007492490.025
regulation of cellular macromolecule biosynthetic processGO:20001122220.024
regulation of cell activationGO:005086510.024
morphogenesis of an epithelial foldGO:006057110.024
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.024
reproductionGO:0000003400.024
Worm
embryonic heart tube morphogenesisGO:00031431080.024
actomyosin structure organizationGO:0031032530.024
head developmentGO:00603223030.024
neuron projection guidanceGO:0097485860.024
regulation of cell morphogenesisGO:0022604420.023
cellular response to dsrnaGO:007135910.023
regulation of signalingGO:00230512350.023
chemotaxisGO:00069351040.023
facial nerve morphogenesisGO:002161010.023
nitrogen compound transportGO:0071705230.023
regulation of intracellular protein transportGO:003315730.023
positive regulation of macromolecule biosynthetic processGO:0010557590.023
response to ketoneGO:190165410.022
positive regulation of apoptotic signaling pathwayGO:200123510.022
negative regulation of response to stimulusGO:00485851040.022
epithelial tube morphogenesisGO:00605621480.022
regulation of synaptic growth at neuromuscular junctionGO:000858210.022
regulation of epithelial cell proliferationGO:005067830.022
regulation of rna biosynthetic processGO:20011412130.021
regulation of protein metabolic processGO:0051246560.021
regenerationGO:0031099910.021
response to drugGO:004249330.021
erythrocyte differentiationGO:0030218540.021
meiotic chromosome segregationGO:004513230.021
negative regulation of programmed cell deathGO:0043069580.021
ion transmembrane transportGO:0034220910.021
translational initiationGO:000641330.021
negative regulation of apoptotic processGO:0043066550.021
cellular amine metabolic processGO:004410620.020
erythrocyte homeostasisGO:0034101550.020
response to uvGO:000941130.020
response to external stimulusGO:00096052640.020
negative regulation of kinase activityGO:003367340.020
mrna export from nucleusGO:000640610.020
maturation of ssu rrna from tricistronic rrna transcript ssu rrna 5 8s rrna lsu rrna GO:000046210.020
organelle localizationGO:0051640490.020
embryonic heart tube developmentGO:00350501330.019
chromosome organizationGO:0051276310.019
protein homooligomerizationGO:005126030.019
spliceosomal complex assemblyGO:000024510.019
Yeast
regulation of localizationGO:00328791040.018
regulation of reproductive processGO:200024140.018
regulation of neurogenesisGO:0050767870.018
amine metabolic processGO:000930820.018
intracellular transportGO:0046907320.018
ion transportGO:00068111140.018
somatic muscle developmentGO:000752540.018
regulation of hematopoietic progenitor cell differentiationGO:190153210.018
negative regulation of cell communicationGO:0010648960.018
cellular response to external stimulusGO:007149620.018
response to external biotic stimulusGO:0043207970.017
embryonic digestive tract morphogenesisGO:004855730.017
protein oligomerizationGO:005125970.017
positive regulation of programmed cell deathGO:0043068290.017
negative regulation of cellular biosynthetic processGO:0031327550.017
cellular component disassemblyGO:002241110.017
cellular response to extracellular stimulusGO:003166820.017
positive regulation of glial cell differentiationGO:004568710.017
maturation of ssu rrnaGO:003049010.017
phosphorylationGO:0016310690.017
response to carbohydrateGO:000974330.017
rna catabolic processGO:000640170.016
proteasomal protein catabolic processGO:001049820.016
endoderm formationGO:0001706290.016
negative regulation of cell deathGO:0060548600.016
ncrna metabolic processGO:0034660120.016
stem cell proliferationGO:007208940.016
ear developmentGO:00435831270.016
rna stabilizationGO:004348940.016
double strand break repairGO:000630230.016
regulation of molecular functionGO:0065009700.016
autonomic nervous system developmentGO:0048483190.016
positive regulation of cellular amino acid metabolic processGO:004576400.016
regulation of cell cycle processGO:0010564200.016
retina development in camera type eyeGO:00600411460.016
proteolysis involved in cellular protein catabolic processGO:005160330.016
positive regulation of developmental processGO:0051094500.016
central nervous system neuron differentiationGO:0021953740.016
protein heterooligomerizationGO:005129110.016
facial nerve developmentGO:002156130.016
negative regulation of translationGO:001714810.015
mononuclear cell proliferationGO:003294310.015
embryonic viscerocranium morphogenesisGO:0048703520.015
positive regulation of rna splicingGO:003312010.015
response to nitrogen compoundGO:1901698190.015
positive regulation of nervous system developmentGO:0051962250.015
pore complex assemblyGO:004693120.015
negative regulation of signalingGO:0023057960.015
protein stabilizationGO:005082120.015
neuroblast proliferationGO:000740520.015
positive regulation of cell cycleGO:004578730.015
branchiomotor neuron axon guidanceGO:002178510.015
positive regulation of epithelial cell proliferationGO:005067910.015
organonitrogen compound metabolic processGO:1901564740.015
embryonic digestive tract developmentGO:004856640.015
somite developmentGO:0061053960.014
skin developmentGO:0043588540.014
regulation of nervous system developmentGO:0051960900.014
cellular protein catabolic processGO:004425740.014
regulation of wound healingGO:006104120.014
phagocytosisGO:000690930.014
somitogenesisGO:0001756870.014
dorsal ventral pattern formationGO:00099531250.014
posttranscriptional regulation of gene expressionGO:0010608140.014
cation transportGO:0006812810.014
positive regulation of cysteine type endopeptidase activity involved in apoptotic processGO:0043280100.014
response to woundingGO:00096111160.014
alternative mrna splicing via spliceosomeGO:000038010.014
negative regulation of defense responseGO:003134820.014
positive regulation of cell activationGO:005086710.014
regulation of protein bindingGO:004339330.014
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.014
regulation of vasculature developmentGO:1901342330.014
synaptic transmissionGO:0007268350.014
regulation of cytokine productionGO:000181730.014
protein modification processGO:00362111000.014
inorganic ion transmembrane transportGO:0098660570.013
posttranscriptional gene silencingGO:001644130.013
regulation of mrna splicing via spliceosomeGO:004802430.013
neuromuscular synaptic transmissionGO:000727420.013
myofibril assemblyGO:0030239480.013
regulation of nucleic acid templated transcriptionGO:19035062130.013
negative regulation of cell developmentGO:0010721260.013
regulation of transportGO:0051049450.013
transmission of nerve impulseGO:0019226190.013
nuclear pore complex assemblyGO:005129220.013
negative regulation of chromosome organizationGO:200125110.013
mechanosensory behaviorGO:000763820.013
regulation of bindingGO:005109830.013
microtubule based processGO:0007017600.013
translationGO:000641250.013
positive regulation of cellular amine metabolic processGO:003324000.013
cellular response to organic substanceGO:00713101050.013
positive regulation of gliogenesisGO:001401520.013
pole plasm assemblyGO:000731540.013
regulation of protein catabolic processGO:004217610.013
cytoplasmic transportGO:0016482110.013
negative regulation of multi organism processGO:004390130.013
negative regulation of protein kinase activityGO:000646940.013
lymphocyte proliferationGO:004665110.013
enzyme linked receptor protein signaling pathwayGO:00071671060.012
oxoacid metabolic processGO:0043436310.012
negative regulation of hormone secretionGO:004688820.012
skeletal system morphogenesisGO:00487051020.012
cognitionGO:005089010.012
spindle localizationGO:0051653120.012
action potentialGO:0001508190.012
cardiac atrium developmentGO:000323040.012
modification dependent macromolecule catabolic processGO:004363230.012
stem cell divisionGO:001714510.012
sexual reproductionGO:0019953360.012
glial cell differentiationGO:0010001420.012
positive regulation of cytosolic calcium ion concentrationGO:000720440.012
regulation of growthGO:0040008420.012
myeloid cell homeostasisGO:0002262560.012
negative regulation of nucleobase containing compound metabolic processGO:0045934590.012
dna templated transcription elongationGO:000635430.012
positive regulation of cell deathGO:0010942290.012
macromolecular complex disassemblyGO:003298410.012
tissue remodelingGO:004877140.012
positive regulation of cellular biosynthetic processGO:0031328680.012
meiotic spindle organizationGO:000021210.011
negative regulation of protein metabolic processGO:0051248160.011
negative regulation of nuclear divisionGO:005178430.011
dsrna fragmentationGO:003105010.011
cranial nerve developmentGO:0021545420.011
adult behaviorGO:003053420.011
heart morphogenesisGO:00030071560.011
specification of symmetryGO:00097992040.011
regulation of protein ubiquitinationGO:003139630.011
mitotic sister chromatid cohesionGO:000706420.011
production of small rna involved in gene silencing by rnaGO:007091810.011
hepaticobiliary system developmentGO:0061008980.011
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.011
regulation of response to stressGO:0080134360.011
phosphorus metabolic processGO:00067931090.011
posttranscriptional gene silencing by rnaGO:003519430.011
ribosomal small subunit biogenesisGO:004227420.011
blood circulationGO:0008015870.011
positive regulation of protein complex assemblyGO:003133420.011
response to steroid hormoneGO:0048545350.011
positive regulation of synaptic growth at neuromuscular junctionGO:004588710.011
inner ear developmentGO:00488391260.011
nuclear body organizationGO:003057520.011

prpf8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.054
Human
cancerDOID:16200.022
disease of cellular proliferationDOID:1456600.022
nervous system diseaseDOID:86300.022
Human
neurodegenerative diseaseDOID:128900.018
amyotrophic lateral sclerosisDOID:33200.018
motor neuron diseaseDOID:23100.018
central nervous system diseaseDOID:33100.018
organ system cancerDOID:005068600.015
disease of metabolismDOID:001466700.011