Danio rerio

7 known processes

pmela

premelanosome protein a

(Aliases: silva,zgc:136622,MGC136622,wu:fc11g11,MGC158124,sb:cb397,fdv,wu:fj24g11,cb397)

pmela biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
pigmentationGO:0043473850.998
pigment cell differentiationGO:0050931380.979
developmental pigmentationGO:0048066480.965
melanocyte differentiationGO:0030318260.862
dopamine metabolic processGO:004241720.860
cellular pigmentationGO:0033059300.856
eye developmentGO:00016542770.836
pigment granule organizationGO:004875340.768
phenol containing compound biosynthetic processGO:004618940.716
camera type eye developmentGO:00430102220.694
melanosome organizationGO:003243840.620
neuroepithelial cell differentiationGO:0060563260.557
columnar cuboidal epithelial cell differentiationGO:0002065380.518
tissue remodelingGO:004877140.399
sensory organ developmentGO:00074233930.399
melanin metabolic processGO:000658220.397
aromatic compound biosynthetic processGO:00194382170.383
regulation of gene expressionGO:00104682650.323
nitrogen compound metabolic processGO:00068073190.322
vesicle organizationGO:001605060.321
larval developmentGO:000216420.313
catecholamine metabolic processGO:000658420.307
catechol containing compound metabolic processGO:000971220.295
secondary metabolic processGO:001974830.238
melanin biosynthetic processGO:004243810.230
alpha amino acid metabolic processGO:190160530.226
retina development in camera type eyeGO:00600411460.224
appendage developmentGO:0048736800.221
embryonic organ morphogenesisGO:00485622740.218
heart morphogenesisGO:00030071560.207
organic cyclic compound biosynthetic processGO:19013622230.201
cellular biosynthetic processGO:00442492860.200
epithelial cell differentiationGO:00308551160.197
positive regulation of tyrosine phosphorylation of stat3 proteinGO:004251710.194
organic substance biosynthetic processGO:19015762890.192
heart developmentGO:00075073130.186
organonitrogen compound metabolic processGO:1901564740.175
regulation of developmental pigmentationGO:004807060.174
chordate embryonic developmentGO:00430092710.171
organic cyclic compound metabolic processGO:19013603010.168
aromatic amino acid family metabolic processGO:000907210.163
catecholamine biosynthetic processGO:004242320.161
regulation of primary metabolic processGO:00800903110.156
heart contractionGO:0060047710.152
catechol containing compound biosynthetic processGO:000971320.151
biosynthetic processGO:00090582940.147
nucleobase containing compound metabolic processGO:00061392740.143
cell morphogenesisGO:00009022890.139
regulation of neural retina developmentGO:006107420.134
wound healingGO:0042060900.134
muscle structure developmentGO:00610611960.129
establishment of localizationGO:00512342440.128
response to woundingGO:00096111160.118
nucleobase containing compound biosynthetic processGO:00346542050.116
central nervous system developmentGO:00074173870.113
regulation of cellular metabolic processGO:00313233200.113
chemosensory behaviorGO:000763510.111
wnt signaling pathwayGO:0016055800.106
notochord cell vacuolationGO:006003670.103
agingGO:000756820.102
regulation of metabolic processGO:00192223590.102
transportGO:00068102200.099
dopamine biosynthetic processGO:004241620.098
ion transmembrane transportGO:0034220910.098
positive regulation of myeloid cell differentiationGO:004563920.096
cellular amine metabolic processGO:004410620.096
regulation of systemic arterial blood pressureGO:000307310.092
deathGO:00162651210.091
immune system developmentGO:00025201910.090
ribonucleoside monophosphate catabolic processGO:000915840.088
cellular nitrogen compound metabolic processGO:00346412900.087
digestive system developmentGO:00551232890.086
melanocyte migrationGO:009732440.086
tyrosine metabolic processGO:000657010.085
positive regulation of erk1 and erk2 cascadeGO:007037420.085
single organism metabolic processGO:00447102170.084
organelle organizationGO:00069962270.080
negative regulation of cellular processGO:00485232830.079
erk1 and erk2 cascadeGO:007037140.077
regulation of tube sizeGO:003515020.076
regulation of muscle contractionGO:000693730.075
embryonic limb morphogenesisGO:003032620.074
response to stressGO:00069502630.074
ear developmentGO:00435831270.073
smooth muscle contractionGO:000693920.071
regulation of autophagyGO:001050630.070
xanthophore differentiationGO:005093630.069
organic hydroxy compound biosynthetic processGO:190161760.069
cellular amino acid metabolic processGO:000652070.067
regulation of cellular biosynthetic processGO:00313262450.067
fin developmentGO:0033333770.066
tube morphogenesisGO:00352393490.065
regulation of multicellular organismal processGO:00512392770.065
nucleoside monophosphate catabolic processGO:000912540.064
gene expressionGO:00104672520.064
transmembrane transportGO:00550851200.061
mesenchyme developmentGO:00604851270.061
actin filament based movementGO:003004810.061
cell projection morphogenesisGO:00488582440.059
neural retina developmentGO:0003407490.058
digestive tract developmentGO:00485652650.058
purine ribonucleoside monophosphate catabolic processGO:000916940.057
regulation of cell shapeGO:000836010.056
embryonic hemopoiesisGO:0035162530.056
regulation of macromolecule metabolic processGO:00602553170.056
apoptotic processGO:00069151160.054
neurological system processGO:0050877620.054
amine metabolic processGO:000930820.054
secondary metabolite biosynthetic processGO:004455010.054
organic acid metabolic processGO:0006082310.054
oxoacid metabolic processGO:0043436310.053
cellular component morphogenesisGO:00329893360.053
positive regulation of tyrosine phosphorylation of stat proteinGO:004253110.053
regulation of blood pressureGO:000821710.053
notochord developmentGO:0030903540.052
notochord cell developmentGO:006003590.051
regulation of erk1 and erk2 cascadeGO:007037240.050
cellular aromatic compound metabolic processGO:00067252950.050
regulation of multicellular organismal developmentGO:20000262230.050
protein secretionGO:000930610.050
cell cell junction maintenanceGO:004521710.049
digestive tract morphogenesisGO:00485462310.049
iridophore differentiationGO:005093590.047
actin mediated cell contractionGO:007025210.047
purine nucleoside monophosphate catabolic processGO:000912840.046
positive regulation of transportGO:005105020.046
embryonic organ developmentGO:00485683810.045
regulation of nucleobase containing compound metabolic processGO:00192192500.045
skeletal system developmentGO:00015011810.045
establishment of organelle localizationGO:0051656450.045
cellular macromolecule metabolic processGO:00442603910.043
single organism biosynthetic processGO:0044711710.042
phenol containing compound metabolic processGO:001895850.042
regulation of cellular macromolecule biosynthetic processGO:20001122220.042
chemical homeostasisGO:0048878490.041
regulation of cell communicationGO:00106462320.041
regulation of cytokine productionGO:000181730.040
cellular component assemblyGO:00226071700.040
regulation of cellular amine metabolic processGO:003323800.040
regulation of developmental processGO:00507932470.039
response to organic substanceGO:00100331530.039
autophagyGO:000691440.039
regulation of bone remodelingGO:004685020.039
monovalent inorganic cation transportGO:0015672420.038
cardiocyte differentiationGO:0035051440.038
cellular component biogenesisGO:00440851780.038
programmed cell deathGO:00125011190.037
embryonic skeletal system morphogenesisGO:0048704930.037
cardiac muscle cell contractionGO:008600310.037
system processGO:00030081850.037
response to external stimulusGO:00096052640.036
regulation of nitrogen compound metabolic processGO:00511712510.036
hemopoiesisGO:00300971830.036
response to light stimulusGO:0009416460.036
rna biosynthetic processGO:00327741810.036
gtp metabolic processGO:004603940.035
cell morphogenesis involved in differentiationGO:00009041950.035
maintenance of locationGO:005123540.035
neuron differentiationGO:00301823530.035
heart processGO:0003015710.035
circulatory system processGO:0003013870.035
morphogenesis of an epithelial sheetGO:0002011490.035
cell surface receptor signaling pathwayGO:00071663250.035
heterocycle biosynthetic processGO:00181302150.035
anterior posterior pattern specificationGO:00099521520.035
cognitionGO:005089010.035
establishment of synaptic vesicle localizationGO:009748010.035
endocrine processGO:005088620.034
neurotransmitter secretionGO:000726920.034
phosphate containing compound metabolic processGO:00067961080.034
renal system process involved in regulation of systemic arterial blood pressureGO:000307110.034
osteoclast developmentGO:003603510.033
organonitrogen compound biosynthetic processGO:1901566470.033
tyrosine phosphorylation of stat proteinGO:000726010.033
atp catabolic processGO:000620040.033
indole containing compound metabolic processGO:004243020.033
single organism transportGO:00447652060.033
transcription dna templatedGO:00063511810.032
negative regulation of catabolic processGO:000989530.032
homeostatic processGO:00425921420.032
negative regulation of programmed cell deathGO:0043069580.032
regulation of cell deathGO:00109411030.032
cellular component movementGO:00069283350.032
nuclear transportGO:005116940.032
carboxylic acid metabolic processGO:0019752220.031
tissue regenerationGO:0042246740.031
regionalizationGO:00030022740.031
regulation of macromolecule biosynthetic processGO:00105562250.031
striated muscle tissue developmentGO:00147061100.031
immune system processGO:00023762410.031
single organism localizationGO:19025782250.031
rna metabolic processGO:00160702190.031
macromolecule biosynthetic processGO:00090592270.030
regulation of nucleoside metabolic processGO:000911820.030
retinal pigment epithelium developmentGO:000340680.030
melanocyte apoptotic processGO:190236220.030
guanosine containing compound catabolic processGO:190106920.030
heterocycle metabolic processGO:00464832900.030
regulation of jak stat cascadeGO:004642530.029
cellular nitrogen compound biosynthetic processGO:00442712180.029
regulation of programmed cell deathGO:00430671010.029
cell projection organizationGO:00300302840.029
adult behaviorGO:003053420.029
regulation of synapse organizationGO:005080730.029
small molecule metabolic processGO:0044281770.028
pigment metabolic processGO:0042440120.028
hematopoietic or lymphoid organ developmentGO:00485341910.028
ribonucleotide biosynthetic processGO:0009260200.028
cilium morphogenesisGO:0060271850.028
regulation of heart contractionGO:0008016320.028
embryonic skeletal system developmentGO:0048706970.028
sensory organ morphogenesisGO:00905962000.028
bone remodelingGO:004684920.028
regulation of biological qualityGO:00650082630.027
response to radiationGO:0009314510.027
cellular response to chemical stimulusGO:00708871570.027
otolith developmentGO:0048840320.027
spermatid developmentGO:000728620.027
negative regulation of metabolic processGO:0009892860.027
regulation of response to stimulusGO:00485832690.027
exocytosisGO:000688710.027
regulation of transcription from rna polymerase iii promoterGO:000635910.026
embryo development ending in birth or egg hatchingGO:00097922710.026
positive regulation of cellular processGO:00485222010.026
cellular biogenic amine metabolic processGO:000657620.025
endosomal transportGO:001619720.025
cell part morphogenesisGO:00329902460.025
regulation of cardiac muscle contractionGO:005511720.025
muscle cell differentiationGO:00426921390.025
blood circulationGO:0008015870.025
multi organism processGO:00517041340.024
canonical wnt signaling pathwayGO:0060070480.024
response to abiotic stimulusGO:00096281220.024
response to alkaloidGO:004327920.024
regulation of peptidyl tyrosine phosphorylationGO:005073010.024
regulation of cardiac muscle cell contractionGO:008600410.024
osteoclast differentiationGO:003031610.024
ion transportGO:00068111140.024
inner ear developmentGO:00488391260.024
regulation of phosphate metabolic processGO:0019220430.024
myeloid cell differentiationGO:0030099860.024
lipid storageGO:001991510.023
serotonin metabolic processGO:004242810.023
inositol lipid mediated signalingGO:004801720.023
regulation of tyrosine phosphorylation of stat proteinGO:004250910.023
purine containing compound metabolic processGO:0072521290.023
phosphorus metabolic processGO:00067931090.023
cell cell signalingGO:0007267520.023
skin developmentGO:0043588540.023
lymphocyte proliferationGO:004665110.023
regulation of apoptotic processGO:0042981980.022
defense response to gram positive bacteriumGO:005083060.022
mononuclear cell migrationGO:007167410.022
tyrosine phosphorylation of stat3 proteinGO:004250310.022
inorganic ion transmembrane transportGO:0098660570.022
cellular localizationGO:0051641970.022
negative regulation of biological processGO:00485193040.022
extrinsic apoptotic signaling pathwayGO:009719130.022
negative regulation of apoptotic processGO:0043066550.021
head developmentGO:00603223030.021
nucleic acid metabolic processGO:00903042440.021
muscle tissue developmentGO:00605371100.021
notochord cell differentiationGO:0060034180.021
determination of bilateral symmetryGO:00098552040.021
embryonic heart tube developmentGO:00350501330.021
rna localizationGO:000640340.021
nucleobase containing small molecule metabolic processGO:0055086320.020
cellular response to external stimulusGO:007149620.020
regulation of actin filament based movementGO:190311510.020
regulation of blood vessel sizeGO:005088020.020
axon guidanceGO:0007411860.020
response to superoxideGO:000030320.020
nucleoside triphosphate biosynthetic processGO:000914220.020
ear morphogenesisGO:0042471640.020
neuron developmentGO:00486662620.020
guanosine containing compound metabolic processGO:190106840.020
positive regulation of catabolic processGO:000989640.020
intracellular signal transductionGO:0035556850.020
neuroblast proliferationGO:000740520.020
cation transportGO:0006812810.020
signal transductionGO:00071654550.020
superoxide metabolic processGO:000680120.020
regulation of striated muscle contractionGO:000694220.019
response to chemicalGO:00422213200.019
regulation of signalingGO:00230512350.019
positive regulation of leukocyte chemotaxisGO:000269010.019
fin regenerationGO:0031101510.019
phagocytosisGO:000690930.019
regulation of signal transductionGO:00099662250.019
urogenital system developmentGO:0001655970.019
positive regulation of biological processGO:00485182530.019
regulation of system processGO:0044057400.019
alcohol biosynthetic processGO:004616520.018
stem cell differentiationGO:00488631170.018
positive regulation of metabolic processGO:00098931080.018
cellular response to reactive oxygen speciesGO:003461420.018
posterior lateral line system developmentGO:0048915460.018
negative regulation of response to stimulusGO:00485851040.018
primary amino compound metabolic processGO:190116010.018
glial cell differentiationGO:0010001420.018
positive regulation of leukocyte migrationGO:000268720.018
regulation of nucleotide catabolic processGO:003081120.018
establishment of localization in cellGO:0051649770.018
regulation of cell activationGO:005086510.018
macromolecule localizationGO:0033036540.018
positive regulation of jak stat cascadeGO:004642720.018
oocyte anterior posterior axis specificationGO:000731440.018
regulation of protein transportGO:005122330.018
locomotionGO:00400113130.018
i kappab kinase nf kappab signalingGO:000724940.018
regulation of rna biosynthetic processGO:20011412130.018
regulation of neuronal synaptic plasticityGO:004816810.018
olfactory bulb developmentGO:002177240.018
synaptic growth at neuromuscular junctionGO:005112420.018
mechanosensory lateral line system developmentGO:0048881490.017
central nervous system neuron differentiationGO:0021953740.017
regulation of biosynthetic processGO:00098892500.017
phosphorylationGO:0016310690.017
pigment biosynthetic processGO:004614890.017
negative regulation of cellular metabolic processGO:0031324770.017
neuron projection guidanceGO:0097485860.017
cellular lipid metabolic processGO:0044255360.017
heart loopingGO:0001947940.017
artery morphogenesisGO:0048844140.017
regulation of synaptic plasticityGO:004816710.017
microglia differentiationGO:001400410.017
specification of symmetryGO:00097992040.017
cellular protein modification processGO:00064641000.017
leukocyte differentiationGO:0002521250.017
nucleoside phosphate metabolic processGO:0006753280.017
synaptic vesicle transportGO:004848910.017
positive regulation of nucleotide catabolic processGO:003081310.016
cardiac muscle cell differentiationGO:0055007300.016
neuromuscular synaptic transmissionGO:000727420.016
regulation of endocrine processGO:004406020.016
nucleic acid templated transcriptionGO:00976591810.016
posterior lateral line developmentGO:0048916380.016
regenerationGO:0031099910.016
response to inorganic substanceGO:0010035380.016
regulation of cellular amino acid metabolic processGO:000652100.016
production of molecular mediator of immune responseGO:000244020.016
regulation of retina development in camera type eyeGO:190286620.016
muscle cell developmentGO:00550011150.016
regulation of gtp catabolic processGO:003312420.016
regulation of transcription dna templatedGO:00063552130.016
regulation of epithelial cell proliferationGO:005067830.016
positive regulation of wound healingGO:009030310.016
developmental programmed cell deathGO:001062340.016
lateral line system developmentGO:0048925760.016
regulation of tyrosine phosphorylation of stat3 proteinGO:004251610.016
axonogenesisGO:00074091520.016
gtp catabolic processGO:000618420.016
sensory system developmentGO:0048880760.016
vesicle localizationGO:0051648270.015
response to biotic stimulusGO:0009607970.015
b cell differentiationGO:003018310.015
insulin like growth factor receptor signaling pathwayGO:004800940.015
cartilage developmentGO:0051216960.015
macromolecule modificationGO:00434121110.015
action potentialGO:0001508190.015
appendage morphogenesisGO:0035107560.015
nucleic acid transportGO:005065720.015
cellular response to molecule of bacterial originGO:007121930.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
leukocyte proliferationGO:007066110.015
positive regulation of cellular catabolic processGO:003133130.015
regulation of multicellular organism growthGO:004001440.015
positive regulation of cell activationGO:005086710.015
cell cycle g1 s phase transitionGO:004484310.015
regulation of blood circulationGO:1903522320.015
positive regulation of cell communicationGO:0010647560.014
generation of neuronsGO:00486993850.014
regulation of membrane potentialGO:0042391230.014
myeloid cell developmentGO:0061515320.014
blood vessel morphogenesisGO:00485142160.014
ph reductionGO:004585110.014
central nervous system myelinationGO:002201020.014
cell proliferationGO:0008283800.014
regulation of nucleic acid templated transcriptionGO:19035062130.014
central nervous system neuron developmentGO:0021954290.014
mononuclear cell proliferationGO:003294310.014
regulation of tissue remodelingGO:003410320.014
positive regulation of response to stimulusGO:0048584800.014
response to uvGO:000941130.014
nuclear exportGO:005116810.014
cell deathGO:00082191210.014
response to metal ionGO:0010038340.014
axon developmentGO:00615641660.014
taxisGO:00423301090.014
transcription from rna polymerase ii promoterGO:0006366800.014
regulation of establishment of protein localizationGO:007020140.014
b cell activationGO:004211320.014
positive regulation of cellular amine metabolic processGO:003324000.014
embryonic retina morphogenesis in camera type eyeGO:0060059220.014
ion homeostasisGO:0050801410.014
regulation of synaptic growth at neuromuscular junctionGO:000858210.014
sphingolipid metabolic processGO:000666590.013
stem cell maintenanceGO:001982740.013
positive regulation of macrophage chemotaxisGO:001075910.013
response to endogenous stimulusGO:0009719830.013
positive regulation of map kinase activityGO:004340630.013
myeloid leukocyte differentiationGO:0002573150.013
glycosyl compound metabolic processGO:1901657110.013
carbohydrate derivative metabolic processGO:1901135610.013
establishment of rna localizationGO:005123630.013
trabecula formationGO:006034320.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.013
positive regulation of signal transductionGO:0009967560.013
axon ensheathment in central nervous systemGO:003229120.013
cellular response to biotic stimulusGO:007121630.013
lateral line developmentGO:0048882660.013
camera type eye photoreceptor cell differentiationGO:0060219190.013
regulation of neurological system processGO:003164420.013
proteasomal protein catabolic processGO:001049820.013
ubiquitin dependent protein catabolic processGO:000651130.013
g1 s transition of mitotic cell cycleGO:000008210.013
phosphatidylinositol mediated signalingGO:004801520.013
lipid metabolic processGO:0006629520.013
embryonic skeletal joint developmentGO:007249830.013
muscle system processGO:0003012200.013
membrane invaginationGO:001032410.013
potassium ion transportGO:0006813100.013
retina morphogenesis in camera type eyeGO:0060042790.013
fin morphogenesisGO:0033334530.012
eye pigmentationGO:004806940.012
regulation of protein catabolic processGO:004217610.012
protein metabolic processGO:00195381830.012
tissue migrationGO:0090130370.012
negative regulation of cell deathGO:0060548600.012
regulation of neurotransmitter secretionGO:004692810.012
organic substance transportGO:0071702580.012
vasculature developmentGO:00019442780.012
regulation of inflammatory responseGO:005072720.012
cell motilityGO:00488702440.012
phagocytosis engulfmentGO:000691110.012
macromolecular complex assemblyGO:0065003350.012
protein localizationGO:0008104400.012
positive regulation of neural precursor cell proliferationGO:200017910.012
renal absorptionGO:007029310.012
spinal cord developmentGO:0021510460.012
phosphatidylinositol 3 kinase signalingGO:001406520.012
ribonucleoside biosynthetic processGO:004245520.012
protein targeting to nucleusGO:004474430.012
kidney developmentGO:0001822920.012
positive regulation of secretionGO:005104710.012
regulation of histone methylationGO:003106030.012
organelle assemblyGO:00709251100.012
cell proliferation in forebrainGO:002184630.012
cell migrationGO:00164772370.012
catabolic processGO:0009056320.012
positive regulation of jnk cascadeGO:004633030.012
regulation of wnt signaling pathwayGO:0030111530.012
purine ribonucleoside biosynthetic processGO:004612920.011
embryonic heart tube morphogenesisGO:00031431080.011
glucose importGO:004632320.011
peptidyl lysine acetylationGO:001839420.011
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.011
response to oxygen containing compoundGO:1901700550.011
positive regulation of cytokine productionGO:000181920.011
phosphatidylinositol metabolic processGO:004648870.011
visual behaviorGO:0007632100.011
camera type eye morphogenesisGO:00485931080.011
regulation of cellular ketone metabolic processGO:001056570.011
negative regulation of cellular catabolic processGO:003133030.011
positive regulation of signalingGO:0023056560.011
purine ribonucleotide metabolic processGO:0009150270.011
positive regulation of secretion by cellGO:190353210.011
epidermal cell differentiationGO:0009913360.011
positive regulation of programmed cell deathGO:0043068290.011
regulation of phGO:000688530.011
positive regulation of apoptotic processGO:0043065290.011
cell morphogenesis involved in neuron differentiationGO:00486671630.011
pole plasm assemblyGO:000731540.011
positive regulation of nitrogen compound metabolic processGO:0051173690.011
cell differentiation in spinal cordGO:0021515400.011
anterior lateral line nerve glial cell developmentGO:004893930.011
macromolecular complex subunit organizationGO:0043933740.011
negative regulation of ras protein signal transductionGO:004658010.011
brain developmentGO:00074202930.011
response to transition metal nanoparticleGO:1990267280.011
ribose phosphate metabolic processGO:0019693270.011
establishment of protein localization to organelleGO:007259440.011
mitochondrion organizationGO:000700540.011

pmela disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of cellular proliferationDOID:1456600.043
cancerDOID:16200.029
immune system diseaseDOID:291400.025
disease of anatomical entityDOID:700.025
organ system cancerDOID:005068600.025
hematopoietic system diseaseDOID:7400.016
eye and adnexa diseaseDOID:149200.016
sensory system diseaseDOID:005015500.016
nervous system diseaseDOID:86300.016
eye diseaseDOID:561400.016
retinal diseaseDOID:567900.011
disease of metabolismDOID:001466700.011