IMP: Integrative Multi-species Prediction

Danio rerio

164 known processes

atp1a1

ATPase, Na+/K+ transporting, alpha 1 polypeptide

(Aliases: atp[a]1B1,wu:fb92h10,atp1a1l1,atp1a1a.1,wu:fa03c03,cb70)

ZFIN: ZDB-GENE-001212-1
Ensembl: ENSDARG00000002791
Entrez: 64612
UniProtKB: Q9DGL6

Process Predictions
Disease Predictions

atp1a1 biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
embryonic organ development	GO:0048568	381	0.992
heart morphogenesis	GO:0003007	156	0.985
ion transmembrane transport	GO:0034220	91	0.981
response to drug	GO:0042493	3	0.970	Mouse
inorganic cation transmembrane transport	GO:0098662	50	0.968
locomotion	GO:0040011	313	0.955
brain development	GO:0007420	293	0.941
chordate embryonic development	GO:0043009	271	0.940
determination of heart left right asymmetry	GO:0061371	117	0.937	Zebrafish
tube morphogenesis	GO:0035239	349	0.920
cellular sodium ion homeostasis	GO:0006883	1	0.917	Human
regulation of metabolic process	GO:0019222	359	0.916	Mouse
response to hormone	GO:0009725	48	0.911	Human
cellular nitrogen compound metabolic process	GO:0034641	290	0.911
response to organic substance	GO:0010033	153	0.904	Human
cellular response to external stimulus	GO:0071496	2	0.901	Rat
organic cyclic compound metabolic process	GO:1901360	301	0.897
nucleoside monophosphate catabolic process	GO:0009125	4	0.896
determination of bilateral symmetry	GO:0009855	204	0.893
ribonucleoside monophosphate catabolic process	GO:0009158	4	0.892
head development	GO:0060322	303	0.887
regionalization	GO:0003002	274	0.881
sensory organ development	GO:0007423	393	0.876
organonitrogen compound metabolic process	GO:1901564	74	0.875
anterior posterior pattern specification	GO:0009952	152	0.873
organelle organization	GO:0006996	227	0.861
determination of left right symmetry	GO:0007368	179	0.858
heart looping	GO:0001947	94	0.855	Zebrafish
larval development	GO:0002164	2	0.851	Worm
atp catabolic process	GO:0006200	4	0.838
nitrogen compound metabolic process	GO:0006807	319	0.821
negative regulation of biological process	GO:0048519	304	0.813	Mouse
transmembrane transport	GO:0055085	120	0.806
cellular biosynthetic process	GO:0044249	286	0.797	Mouse
specification of symmetry	GO:0009799	204	0.791
sensory organ morphogenesis	GO:0090596	200	0.787
positive regulation of biological process	GO:0048518	253	0.769	Mouse
cation transmembrane transport	GO:0098655	65	0.737
neurological system process	GO:0050877	62	0.728	Fly
heterocycle metabolic process	GO:0046483	290	0.719
ion transport	GO:0006811	114	0.718
regulation of gene expression	GO:0010468	265	0.715
embryonic organ morphogenesis	GO:0048562	274	0.711
embryo development ending in birth or egg hatching	GO:0009792	271	0.693
regulation of anatomical structure morphogenesis	GO:0022603	130	0.674	Fly
organic cyclic compound biosynthetic process	GO:1901362	223	0.663	Mouse
organic substance biosynthetic process	GO:1901576	289	0.654	Mouse
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.648
aging	GO:0007568	2	0.642	Fly
central nervous system development	GO:0007417	387	0.625
eye development	GO:0001654	277	0.622
nucleobase containing compound biosynthetic process	GO:0034654	205	0.607
nucleobase containing compound metabolic process	GO:0006139	274	0.601
inorganic ion transmembrane transport	GO:0098660	57	0.600
regulation of nitrogen compound metabolic process	GO:0051171	251	0.598
cellular component assembly	GO:0022607	170	0.592	Fly
epithelial tube morphogenesis	GO:0060562	148	0.590
cellular component biogenesis	GO:0044085	178	0.585	Fly
system process	GO:0003008	185	0.583	Zebrafish Mouse Rat Worm Fly
regulation of macromolecule metabolic process	GO:0060255	317	0.581
positive regulation of blood circulation	GO:1903524	2	0.570	Mouse
regulation of multicellular organismal process	GO:0051239	277	0.569	Mouse Rat Worm
purine nucleoside monophosphate catabolic process	GO:0009128	4	0.569
cellular response to chemical stimulus	GO:0070887	157	0.565	Human
embryonic heart tube morphogenesis	GO:0003143	108	0.562
vasculature development	GO:0001944	278	0.559
regulation of cellular metabolic process	GO:0031323	320	0.507	Mouse
blood vessel morphogenesis	GO:0048514	216	0.491
cellular aromatic compound metabolic process	GO:0006725	295	0.490
cellular response to hormone stimulus	GO:0032870	39	0.482	Human
regulation of blood circulation	GO:1903522	32	0.473	Mouse Rat
somitogenesis	GO:0001756	87	0.472
cellular cation homeostasis	GO:0030003	17	0.472	Human Zebrafish
nucleic acid metabolic process	GO:0090304	244	0.467
biosynthetic process	GO:0009058	294	0.466	Mouse
heart development	GO:0007507	313	0.461
positive regulation of cellular process	GO:0048522	201	0.459
membrane hyperpolarization	GO:0060081	1	0.458	Rat
cellular localization	GO:0051641	97	0.454
reproduction	GO:0000003	40	0.451	Worm
regulation of apoptotic process	GO:0042981	98	0.447
segmentation	GO:0035282	97	0.439
regulation of primary metabolic process	GO:0080090	311	0.439	Mouse
gene expression	GO:0010467	252	0.420
small molecule metabolic process	GO:0044281	77	0.410
response to abiotic stimulus	GO:0009628	122	0.407	Rat Fly
aromatic compound biosynthetic process	GO:0019438	217	0.402
establishment of localization	GO:0051234	244	0.389
membrane repolarization	GO:0086009	2	0.387	Human
heart process	GO:0003015	71	0.386	Zebrafish Mouse Rat
organonitrogen compound biosynthetic process	GO:1901566	47	0.385
regulation of metal ion transport	GO:0010959	4	0.384	Rat
carbohydrate derivative metabolic process	GO:1901135	61	0.384
morphogenesis of an epithelium	GO:0002009	333	0.382
otolith development	GO:0048840	32	0.375
multicellular organismal homeostasis	GO:0048871	29	0.373	Fly
embryonic pattern specification	GO:0009880	44	0.372
localization of cell	GO:0051674	244	0.372
digestive tract development	GO:0048565	265	0.368
negative regulation of heart contraction	GO:0045822	2	0.367	Mouse
cellular response to extracellular stimulus	GO:0031668	2	0.365
positive regulation of transcription dna templated	GO:0045893	57	0.363
mitochondrion organization	GO:0007005	4	0.359
camera type eye development	GO:0043010	222	0.355
regulation of cell communication	GO:0010646	232	0.343
transcription dna templated	GO:0006351	181	0.341
regulation of eye photoreceptor cell development	GO:0042478	2	0.339
negative regulation of metabolic process	GO:0009892	86	0.336	Mouse
regulation of cellular biosynthetic process	GO:0031326	245	0.330	Mouse
glial cell differentiation	GO:0010001	42	0.329
metal ion homeostasis	GO:0055065	26	0.326	Human Zebrafish
blood circulation	GO:0008015	87	0.325	Zebrafish Mouse Rat
auditory receptor cell morphogenesis	GO:0002093	4	0.317
regulation of developmental process	GO:0050793	247	0.313	Fly
circulatory system process	GO:0003013	87	0.307	Zebrafish Mouse Rat
programmed cell death	GO:0012501	119	0.304
response to endogenous stimulus	GO:0009719	83	0.301	Human
phosphate containing compound metabolic process	GO:0006796	108	0.301
cellular response to starvation	GO:0009267	1	0.301
cell death	GO:0008219	121	0.294
rna metabolic process	GO:0016070	219	0.288
heart contraction	GO:0060047	71	0.283	Zebrafish Mouse Rat
heterocycle biosynthetic process	GO:0018130	215	0.282
phosphorus metabolic process	GO:0006793	109	0.282
cation transport	GO:0006812	81	0.281
regulation of localization	GO:0032879	104	0.273	Rat
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.273
stem cell differentiation	GO:0048863	117	0.270
single organism organelle organization	GO:1902589	199	0.267
cellular response to endogenous stimulus	GO:0071495	68	0.264	Human
regulation of biological quality	GO:0065008	263	0.263	Human Zebrafish Mouse Rat Worm Fly
regulation of signal transduction	GO:0009966	225	0.262
renal system development	GO:0072001	94	0.261
regulation of protein binding	GO:0043393	3	0.260
pigmentation	GO:0043473	85	0.259
lens development in camera type eye	GO:0002088	22	0.255
transport	GO:0006810	220	0.254
pigment cell differentiation	GO:0050931	38	0.253
cellular chemical homeostasis	GO:0055082	17	0.253	Human Zebrafish
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.249
atp metabolic process	GO:0046034	5	0.249
single organism metabolic process	GO:0044710	217	0.248
cell motility	GO:0048870	244	0.247
single organism localization	GO:1902578	225	0.246
meiotic cell cycle process	GO:1903046	3	0.246
mesenchyme development	GO:0060485	127	0.243
purine ribonucleoside monophosphate metabolic process	GO:0009167	5	0.240
apoptotic process	GO:0006915	116	0.239
lipid storage	GO:0019915	1	0.234
transcription from rna polymerase ii promoter	GO:0006366	80	0.233
cellular response to nutrient levels	GO:0031669	2	0.230
respiratory electron transport chain	GO:0022904	2	0.227
cell cycle	GO:0007049	93	0.227
establishment of epithelial cell polarity	GO:0090162	2	0.224
regulation of ion transport	GO:0043269	22	0.222	Rat
regulation of establishment of protein localization	GO:0070201	4	0.222
regulation of transport	GO:0051049	45	0.221	Rat
response to lipid	GO:0033993	60	0.219	Human
cellular aldehyde metabolic process	GO:0006081	4	0.219
purine ribonucleoside monophosphate catabolic process	GO:0009169	4	0.219
response to external stimulus	GO:0009605	264	0.217	Zebrafish Rat Fly
hematopoietic progenitor cell differentiation	GO:0002244	23	0.212
regulation of oligodendrocyte differentiation	GO:0048713	1	0.212
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.211
single organism transport	GO:0044765	206	0.211
neural tube development	GO:0021915	62	0.211
protein metabolic process	GO:0019538	183	0.204	Worm
blood vessel development	GO:0001568	246	0.200
carboxylic acid metabolic process	GO:0019752	22	0.197
positive regulation of metabolic process	GO:0009893	108	0.189
cellular response to organic cyclic compound	GO:0071407	38	0.188	Human
photoreceptor cell fate commitment	GO:0046552	1	0.188
maintenance of location	GO:0051235	4	0.188
neural crest cell differentiation	GO:0014033	72	0.187
regulation of protein metabolic process	GO:0051246	56	0.187
positive regulation of macromolecule metabolic process	GO:0010604	93	0.187
regulation of rna biosynthetic process	GO:2001141	213	0.183
response to other organism	GO:0051707	97	0.183
signal transduction	GO:0007165	455	0.183
regulation of molecular function	GO:0065009	70	0.182
cellular macromolecule metabolic process	GO:0044260	391	0.181
kidney development	GO:0001822	92	0.178
hemopoiesis	GO:0030097	183	0.177
regulation of programmed cell death	GO:0043067	101	0.176
regulation of circadian rhythm	GO:0042752	4	0.176
response to antibiotic	GO:0046677	1	0.175
positive regulation of signal transduction	GO:0009967	56	0.175
metal ion transport	GO:0030001	58	0.174
cation homeostasis	GO:0055080	33	0.171	Human Zebrafish
single organism biosynthetic process	GO:0044711	71	0.166	Mouse
establishment of cell polarity involved in gastrulation cell migration	GO:0003379	2	0.166
purine nucleotide metabolic process	GO:0006163	27	0.162
homeostatic process	GO:0042592	142	0.162	Human Zebrafish Fly
regulation of cardiac muscle contraction	GO:0055117	2	0.161	Rat
intracellular signal transduction	GO:0035556	85	0.161
cell cycle process	GO:0022402	53	0.161
regulation of signaling	GO:0023051	235	0.160
regulation of multicellular organism growth	GO:0040014	4	0.160
establishment of localization in cell	GO:0051649	77	0.158
positive regulation of rna metabolic process	GO:0051254	59	0.158
regulation of system process	GO:0044057	40	0.157	Mouse Rat Worm
regulation of ion transmembrane transporter activity	GO:0032412	2	0.157
regulation of nucleic acid templated transcription	GO:1903506	213	0.155
negative regulation of cellular process	GO:0048523	283	0.153	Mouse
protein complex subunit organization	GO:0071822	46	0.153
cardiac atrium morphogenesis	GO:0003209	2	0.152
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.151
actin filament based process	GO:0030029	64	0.147	Rat
positive regulation of catabolic process	GO:0009896	4	0.147
establishment of protein localization to plasma membrane	GO:0090002	1	0.145
endocardial cushion formation	GO:0003272	2	0.145
nucleic acid templated transcription	GO:0097659	181	0.143
gamete generation	GO:0007276	33	0.143
embryonic hemopoiesis	GO:0035162	53	0.142
negative regulation of transcription dna templated	GO:0045892	45	0.142
sensory perception of mechanical stimulus	GO:0050954	16	0.141	Fly
regulation of muscle contraction	GO:0006937	3	0.140	Mouse Rat Worm
embryonic heart tube development	GO:0035050	133	0.140
heart valve formation	GO:0003188	4	0.138
regulation of transcription dna templated	GO:0006355	213	0.138
regulation of response to stimulus	GO:0048583	269	0.138
stem cell development	GO:0048864	82	0.134
cellular component assembly involved in morphogenesis	GO:0010927	107	0.133
regulation of rna metabolic process	GO:0051252	224	0.133
regulation of retina development in camera type eye	GO:1902866	2	0.131
cellular response to antibiotic	GO:0071236	1	0.130
positive regulation of biosynthetic process	GO:0009891	68	0.130
negative regulation of gene expression	GO:0010629	65	0.130
ion homeostasis	GO:0050801	41	0.129	Human Zebrafish
cellular response to growth factor stimulus	GO:0071363	39	0.126
mesendoderm development	GO:0048382	10	0.126
immune system process	GO:0002376	241	0.126
inner ear receptor stereocilium organization	GO:0060122	8	0.123
regulation of membrane potential	GO:0042391	23	0.121	Human Rat Worm
negative regulation of stem cell differentiation	GO:2000737	2	0.121
axis elongation involved in somitogenesis	GO:0090245	2	0.121
reproductive process	GO:0022414	40	0.120
establishment of cell polarity involved in mesendodermal cell migration	GO:0003369	1	0.119
semicircular canal development	GO:0060872	24	0.119	Zebrafish
oxoacid metabolic process	GO:0043436	31	0.119
cell migration involved in heart development	GO:0060973	22	0.119
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.118
muscle structure development	GO:0061061	196	0.118	Zebrafish
epithelial cell morphogenesis	GO:0003382	2	0.117
negative regulation of molecular function	GO:0044092	23	0.117
aromatic compound catabolic process	GO:0019439	15	0.115
regulation of transmembrane transporter activity	GO:0022898	2	0.115
negative regulation of cellular biosynthetic process	GO:0031327	55	0.113	Mouse
positive regulation of transport	GO:0051050	2	0.113
dorsal motor nucleus of vagus nerve development	GO:0021744	4	0.113
response to oxygen containing compound	GO:1901700	55	0.111	Human
ventricular cardiac muscle tissue morphogenesis	GO:0055010	2	0.111
regulation of cell cycle	GO:0051726	52	0.110
forebrain development	GO:0030900	96	0.108
endocardial cushion morphogenesis	GO:0003203	3	0.108
cell migration	GO:0016477	237	0.108
organic substance transport	GO:0071702	58	0.107
anatomical structure arrangement	GO:0048532	2	0.107
macromolecule modification	GO:0043412	111	0.106
inner ear development	GO:0048839	126	0.106
axon development	GO:0061564	166	0.105
regulation of catalytic activity	GO:0050790	55	0.105
cellular monovalent inorganic cation homeostasis	GO:0030004	2	0.105	Human
death	GO:0016265	121	0.105
endodermal digestive tract morphogenesis	GO:0061031	2	0.104
negative regulation of macromolecule metabolic process	GO:0010605	76	0.102
response to starvation	GO:0042594	5	0.101
regulation of cellular protein metabolic process	GO:0032268	52	0.101
positive regulation of cellular biosynthetic process	GO:0031328	68	0.099
neurotransmitter transport	GO:0006836	2	0.099
purine nucleoside monophosphate metabolic process	GO:0009126	5	0.098
glycosyl compound metabolic process	GO:1901657	11	0.098
organic acid metabolic process	GO:0006082	31	0.098
nucleocytoplasmic transport	GO:0006913	4	0.097
macromolecular complex subunit organization	GO:0043933	74	0.096
regulation of heart contraction	GO:0008016	32	0.095	Mouse Rat
muscle system process	GO:0003012	20	0.094	Mouse Rat Worm
meiotic nuclear division	GO:0007126	4	0.093
mesenchymal cell development	GO:0014031	78	0.093
response to carbohydrate	GO:0009743	3	0.091
developmental growth	GO:0048589	166	0.091	Fly
cellular component morphogenesis	GO:0032989	336	0.091	Fly
positive regulation of cellular catabolic process	GO:0031331	3	0.091
odontogenesis of dentin containing tooth	GO:0042475	1	0.088
regulation of transmembrane transport	GO:0034762	18	0.087
mitotic cell cycle process	GO:1903047	48	0.087
monovalent inorganic cation transport	GO:0015672	42	0.086
response to external biotic stimulus	GO:0043207	97	0.086
protein localization to plasma membrane	GO:0072659	1	0.086
response to oxidative stress	GO:0006979	11	0.084
cardiac atrium development	GO:0003230	4	0.084
hepaticobiliary system development	GO:0061008	98	0.083
regulation of biosynthetic process	GO:0009889	250	0.083	Mouse
somite development	GO:0061053	96	0.082
regulation of binding	GO:0051098	3	0.082
response to growth factor	GO:0070848	39	0.081
cellular response to organic substance	GO:0071310	105	0.081	Human
establishment of protein localization to membrane	GO:0090150	3	0.081
regulation of multicellular organismal development	GO:2000026	223	0.080
negative regulation of biosynthetic process	GO:0009890	55	0.080	Mouse
meiotic chromosome segregation	GO:0045132	3	0.080
anatomical structure homeostasis	GO:0060249	36	0.080	Fly
response to nutrient levels	GO:0031667	10	0.079
gastrulation with mouth forming second	GO:0001702	44	0.078
sodium ion homeostasis	GO:0055078	3	0.078	Human
otolith morphogenesis	GO:0032474	8	0.078
aorta morphogenesis	GO:0035909	3	0.078
regulation of protein transport	GO:0051223	3	0.077
gland development	GO:0048732	143	0.077
positive regulation of response to stimulus	GO:0048584	80	0.077
neuron differentiation	GO:0030182	353	0.077
negative regulation of cellular metabolic process	GO:0031324	77	0.076	Mouse
ribose phosphate metabolic process	GO:0019693	27	0.076
regulation of neural retina development	GO:0061074	2	0.075
cellular protein metabolic process	GO:0044267	129	0.075
regulation of biomineral tissue development	GO:0070167	2	0.074
posterior lateral line system development	GO:0048915	46	0.074
cellular response to oxygen containing compound	GO:1901701	20	0.074
regulation of neurogenesis	GO:0050767	87	0.073
multicellular organismal reproductive process	GO:0048609	35	0.073
establishment of monopolar cell polarity	GO:0061162	2	0.072
nephron epithelium morphogenesis	GO:0072088	1	0.072
catabolic process	GO:0009056	32	0.072
carbohydrate derivative biosynthetic process	GO:1901137	43	0.071
cytoskeleton organization	GO:0007010	96	0.071
cardiocyte differentiation	GO:0035051	44	0.071
oligodendrocyte differentiation	GO:0048709	23	0.069
purine ribonucleotide catabolic process	GO:0009154	6	0.069
response to copper ion	GO:0046688	13	0.069
regulation of phosphorus metabolic process	GO:0051174	43	0.068
generation of neurons	GO:0048699	385	0.068
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.068
single organism reproductive process	GO:0044702	40	0.068
cellular component movement	GO:0006928	335	0.066
regulation of protein targeting	GO:1903533	2	0.066
protein import	GO:0017038	3	0.065
eye morphogenesis	GO:0048592	144	0.065
organophosphate metabolic process	GO:0019637	37	0.065
reactive oxygen species metabolic process	GO:0072593	6	0.065
post embryonic development	GO:0009791	7	0.065	Worm
compound eye development	GO:0048749	2	0.064
response to decreased oxygen levels	GO:0036293	25	0.064
regulation of macromolecule biosynthetic process	GO:0010556	225	0.064
endocardial cushion development	GO:0003197	6	0.064
cell projection morphogenesis	GO:0048858	244	0.064
anion transport	GO:0006820	38	0.063
cellular amino acid metabolic process	GO:0006520	7	0.063
regulation of cell development	GO:0060284	100	0.063
microtubule organizing center organization	GO:0031023	1	0.063
cell cycle g1 s phase transition	GO:0044843	1	0.063
cellular ion homeostasis	GO:0006873	17	0.062	Human Zebrafish
cellular macromolecule localization	GO:0070727	21	0.062
cellular homeostasis	GO:0019725	26	0.062	Human Zebrafish
response to biotic stimulus	GO:0009607	97	0.062
left right pattern formation	GO:0060972	19	0.061
macromolecular complex assembly	GO:0065003	35	0.061
nuclear transport	GO:0051169	4	0.061
positive regulation of cellular metabolic process	GO:0031325	94	0.060
adherens junction maintenance	GO:0034334	2	0.060
rna biosynthetic process	GO:0032774	181	0.060
apoptotic process involved in development	GO:1902742	2	0.059
regulation of cytokine production	GO:0001817	3	0.059
protein polymerization	GO:0051258	4	0.059
tissue regeneration	GO:0042246	74	0.059
cell type specific apoptotic process	GO:0097285	22	0.059
cellular component disassembly	GO:0022411	1	0.059
regulation of striated muscle contraction	GO:0006942	2	0.058	Mouse Rat
digestive tract morphogenesis	GO:0048546	231	0.058
response to hexose	GO:0009746	3	0.058
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.058
negative regulation of cell death	GO:0060548	60	0.057
macromolecule biosynthetic process	GO:0009059	227	0.057
positive regulation of cellular amine metabolic process	GO:0033240	0	0.056
cell cell adhesion involved in mesendodermal cell migration	GO:0003370	1	0.056
positive regulation of gliogenesis	GO:0014015	2	0.056
response to chemical	GO:0042221	320	0.056	Human Mouse
muscle tissue development	GO:0060537	110	0.055	Zebrafish
response to extracellular stimulus	GO:0009991	10	0.055
monovalent inorganic cation homeostasis	GO:0055067	9	0.055	Human
heart jogging	GO:0003146	40	0.054
establishment of apical basal cell polarity	GO:0035089	2	0.054
regulation of sodium ion transmembrane transporter activity	GO:2000649	1	0.054
ameboidal type cell migration	GO:0001667	143	0.054
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.054
positive regulation of rna biosynthetic process	GO:1902680	57	0.054
lateral inhibition	GO:0046331	1	0.053
urogenital system development	GO:0001655	97	0.053
regulation of cell death	GO:0010941	103	0.053
regulation of cellular component organization	GO:0051128	86	0.053	Fly
regulation of intracellular protein transport	GO:0033157	3	0.053
regulation of heart growth	GO:0060420	2	0.052
cell surface receptor signaling pathway	GO:0007166	325	0.052
establishment of protein localization to organelle	GO:0072594	4	0.052
activation of mapkkk activity	GO:0000185	1	0.052
biological adhesion	GO:0022610	40	0.052
regulation of transporter activity	GO:0032409	2	0.052
response to stress	GO:0006950	263	0.052
cell migration involved in mesendoderm migration	GO:0090134	2	0.051
regulation of sodium ion transport	GO:0002028	2	0.051	Rat
regulation of locomotion	GO:0040012	55	0.051
positive regulation of cellular component biogenesis	GO:0044089	3	0.051
regulation of transcription from rna polymerase ii promoter in response to stress	GO:0043618	0	0.051
chemical homeostasis	GO:0048878	49	0.050	Human Zebrafish
response to radiation	GO:0009314	51	0.050
negative regulation of macromolecule biosynthetic process	GO:0010558	48	0.050
protein localization	GO:0008104	40	0.050
positive regulation of cell cycle	GO:0045787	3	0.049
response to inorganic substance	GO:0010035	38	0.049
embryonic digestive tract morphogenesis	GO:0048557	3	0.049
aorta development	GO:0035904	4	0.048
negative regulation of programmed cell death	GO:0043069	58	0.048
cellular component maintenance	GO:0043954	3	0.048
posttranscriptional gene silencing	GO:0016441	3	0.047
cell projection organization	GO:0030030	284	0.047
cellular response to topologically incorrect protein	GO:0035967	2	0.047
regulation of cell shape	GO:0008360	1	0.047	Fly
extracellular matrix constituent secretion	GO:0070278	3	0.046
connective tissue development	GO:0061448	99	0.046
regulation of cytoplasmic transport	GO:1903649	4	0.046
negative regulation of rna metabolic process	GO:0051253	48	0.046
neuron development	GO:0048666	262	0.046
epithelial cell differentiation	GO:0030855	116	0.045
retina development in camera type eye	GO:0060041	146	0.045
negative regulation of neural precursor cell proliferation	GO:2000178	1	0.045
regulation of gene expression epigenetic	GO:0040029	11	0.045
centrosome organization	GO:0051297	1	0.045
regulation of protein ubiquitination	GO:0031396	3	0.044
purine containing compound metabolic process	GO:0072521	29	0.044
response to monosaccharide	GO:0034284	3	0.044
muscle cell development	GO:0055001	115	0.044
platelet morphogenesis	GO:0036344	1	0.044
regulation of cell morphogenesis	GO:0022604	42	0.044	Fly
growth	GO:0040007	174	0.043	Worm Fly
positive regulation of glial cell differentiation	GO:0045687	1	0.043
cell fate commitment	GO:0045165	99	0.043
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.043
response to transition metal nanoparticle	GO:1990267	28	0.042
response to organic cyclic compound	GO:0014070	51	0.042	Human
negative regulation of protein kinase activity	GO:0006469	4	0.042
digestive system development	GO:0055123	289	0.041
mesendoderm migration	GO:0090133	2	0.041
female gamete generation	GO:0007292	14	0.041
hormone biosynthetic process	GO:0042446	3	0.041	Mouse
inner ear receptor cell development	GO:0060119	20	0.040
protein targeting to nucleus	GO:0044744	3	0.040
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.040
organelle assembly	GO:0070925	110	0.040
regulation of protein localization to plasma membrane	GO:1903076	1	0.040
basement membrane assembly	GO:0070831	3	0.040
mesoderm development	GO:0007498	88	0.040
membrane organization	GO:0061024	21	0.039
positive regulation of heart contraction	GO:0045823	2	0.039	Mouse
inner ear morphogenesis	GO:0042472	63	0.039
mitochondrial transport	GO:0006839	2	0.039
negative regulation of rna biosynthetic process	GO:1902679	45	0.039
rhythmic process	GO:0048511	21	0.039
posttranscriptional gene silencing by rna	GO:0035194	3	0.039
positive regulation of cell communication	GO:0010647	56	0.039
negative regulation of apoptotic process	GO:0043066	55	0.038
heart valve morphogenesis	GO:0003179	8	0.038
embryonic viscerocranium morphogenesis	GO:0048703	52	0.038
regulation of protein modification by small protein conjugation or removal	GO:1903320	3	0.038
establishment or maintenance of monopolar cell polarity	GO:0061339	2	0.038
regulation of neural precursor cell proliferation	GO:2000177	3	0.038
liver development	GO:0001889	96	0.038
developmental programmed cell death	GO:0010623	4	0.038
immune system development	GO:0002520	191	0.037
mechanosensory lateral line system development	GO:0048881	49	0.037
positive regulation of oligodendrocyte differentiation	GO:0048714	1	0.036
outflow tract morphogenesis	GO:0003151	1	0.036
pole plasm assembly	GO:0007315	4	0.036
amine metabolic process	GO:0009308	2	0.036
negative regulation of blood circulation	GO:1903523	2	0.036	Mouse
small molecule catabolic process	GO:0044282	3	0.036
muscle organ development	GO:0007517	101	0.036	Zebrafish
regulation of bone mineralization	GO:0030500	2	0.036
peptide metabolic process	GO:0006518	1	0.035
striated muscle contraction	GO:0006941	12	0.035	Mouse Rat
protein import into nucleus	GO:0006606	3	0.035
positive regulation of multicellular organismal process	GO:0051240	52	0.035	Mouse
cellular response to lipid	GO:0071396	39	0.035	Human
epiboly involved in gastrulation with mouth forming second	GO:0055113	35	0.034
multi organism cellular process	GO:0044764	2	0.034
cardiac muscle tissue development	GO:0048738	48	0.034
positive regulation of cellular protein metabolic process	GO:0032270	22	0.034
cellular macromolecule biosynthetic process	GO:0034645	224	0.034
intracellular transport	GO:0046907	32	0.034
ventricular cardiac muscle tissue development	GO:0003229	3	0.034
protein localization to nucleus	GO:0034504	3	0.034
cellular protein modification process	GO:0006464	100	0.034
skeletal system development	GO:0001501	181	0.033
regulation of nucleoside metabolic process	GO:0009118	2	0.033
microtubule based process	GO:0007017	60	0.033
reciprocal meiotic recombination	GO:0007131	1	0.033
protein complex assembly	GO:0006461	30	0.033
angiogenesis	GO:0001525	158	0.033

atp1a1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
hematopoietic system disease	DOID:74	0.060
immune system disease	DOID:2914	0.060
disease of anatomical entity	DOID:7	0.060

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