Danio rerio

4 known processes

park7

parkinson disease (autosomal recessive, early onset) 7

(Aliases: dj1,zgc:103725)

park7 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
response to oxygen radicalGO:000030520.681
Human
oxidation reduction processGO:0055114410.640
Human Mouse
hydrogen peroxide metabolic processGO:004274320.579
Human Mouse
removal of superoxide radicalsGO:001943020.543
Human
cellular respirationGO:004533330.523
Human Mouse
regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217520.523
Human Mouse
regulation of cellular metabolic processGO:00313233200.409
Human Mouse
larval developmentGO:000216420.382
intrinsic apoptotic signaling pathway in response to oxidative stressGO:000863120.327
Human Mouse
cellular macromolecule metabolic processGO:00442603910.326
Human Mouse
regulation of biological qualityGO:00650082630.245
Human Mouse
cellular response to superoxideGO:007145120.226
Human
agingGO:000756820.223
negative regulation of oxidative stress induced intrinsic apoptotic signaling pathwayGO:190217620.223
Human
sensory organ developmentGO:00074233930.220
regulation of molecular functionGO:0065009700.213
Human Mouse
reactive oxygen species biosynthetic processGO:190340910.200
Mouse
protein modification processGO:00362111000.190
Human Mouse
negative regulation of programmed cell deathGO:0043069580.186
Human Mouse
small molecule catabolic processGO:004428230.170
Human Mouse
regulation of macromolecule metabolic processGO:00602553170.164
Human Mouse
cellular aromatic compound metabolic processGO:00067252950.160
Human Mouse
signal transductionGO:00071654550.159
Human Mouse
single organism metabolic processGO:00447102170.146
Human Mouse
small molecule metabolic processGO:0044281770.146
Human Mouse
negative regulation of cellular processGO:00485232830.138
Human Mouse
cellular ketone metabolic processGO:0042180110.138
Human Mouse
response to superoxideGO:000030320.133
Human
gene expressionGO:00104672520.127
Human Mouse
cellular response to oxygen radicalGO:007145020.126
Human
organic substance biosynthetic processGO:19015762890.122
Human Mouse
nucleobase containing compound metabolic processGO:00061392740.116
Human Mouse
regulation of macromolecule biosynthetic processGO:00105562250.114
Human Mouse
organic acid metabolic processGO:0006082310.112
Human Mouse
regulation of apoptotic processGO:0042981980.110
Human Mouse
ribonucleoside monophosphate catabolic processGO:000915840.109
generation of neuronsGO:00486993850.107
cellular protein metabolic processGO:00442671290.102
Human Mouse
regulation of reactive oxygen species metabolic processGO:200037720.100
Human Mouse
organic cyclic compound metabolic processGO:19013603010.099
Human Mouse
response to chemicalGO:00422213200.095
Human Mouse
programmed cell deathGO:00125011190.093
Human Mouse
regulation of cell communicationGO:00106462320.090
Human Mouse
nitrogen compound metabolic processGO:00068073190.088
Human Mouse
regulation of metabolic processGO:00192223590.087
Human Mouse
camera type eye developmentGO:00430102220.084
regulation of primary metabolic processGO:00800903110.081
Human Mouse
superoxide metabolic processGO:000680120.079
Human
regulation of response to oxidative stressGO:190288220.077
Human Mouse
single organism biosynthetic processGO:0044711710.077
Human Mouse
digestive system developmentGO:00551232890.076
multicellular organism growthGO:003526440.070
dicarboxylic acid metabolic processGO:004364810.068
intracellular signal transductionGO:0035556850.067
Human Mouse
regulation of protein metabolic processGO:0051246560.067
Human Mouse
cellular amide metabolic processGO:004360340.067
reactive nitrogen species metabolic processGO:200105700.065
organonitrogen compound metabolic processGO:1901564740.064
Human Mouse
apoptotic processGO:00069151160.063
Human Mouse
macromolecule modificationGO:00434121110.062
Human Mouse
regulation of transcription from rna polymerase ii promoter in response to oxidative stressGO:004361900.061
regulation of cellular ketone metabolic processGO:001056570.061
Human
muscle cell differentiationGO:00426921390.060
regulation of signal transductionGO:00099662250.059
Human Mouse
cellular protein modification processGO:00064641000.058
Human Mouse
neurotransmitter transportGO:000683620.058
Mouse
regulation of autophagyGO:001050630.056
response to hormoneGO:0009725480.056
Human
eye developmentGO:00016542770.055
cellular catabolic processGO:0044248270.055
Human Mouse
internal protein amino acid acetylationGO:000647520.054
cell deathGO:00082191210.054
Human Mouse
autophagyGO:000691440.052
nitric oxide biosynthetic processGO:000680920.051
positive regulation of rho protein signal transductionGO:003502500.051
multicellular organismal response to stressGO:003355520.051
regulation of gene expressionGO:00104682650.051
Human Mouse
cellular modified amino acid metabolic processGO:000657530.050
Human
carboxylic acid metabolic processGO:0019752220.049
Human Mouse
mechanosensory behaviorGO:000763820.049
cytoskeleton dependent intracellular transportGO:0030705100.049
organelle organizationGO:00069962270.048
Mouse
regulation of multicellular organism growthGO:004001440.048
cellular nitrogen compound metabolic processGO:00346412900.047
Human Mouse
central nervous system developmentGO:00074173870.047
hepaticobiliary system developmentGO:0061008980.046
cellular biosynthetic processGO:00442492860.046
Human Mouse
response to metal ionGO:0010038340.045
cellular response to lipopolysaccharideGO:007122230.045
peptide metabolic processGO:000651810.045
regulation of cell deathGO:00109411030.045
Human Mouse
positive regulation of metabolic processGO:00098931080.045
Human Mouse
cellular amino acid metabolic processGO:000652070.044
Human
amine metabolic processGO:000930820.044
Human
regulation of cellular protein metabolic processGO:0032268520.044
Human Mouse
regulation of cellular biosynthetic processGO:00313262450.044
Human Mouse
regulation of cellular response to oxidative stressGO:190040720.042
Human Mouse
positive regulation of cellular amino acid metabolic processGO:004576400.042
Human
response to organic substanceGO:00100331530.042
Human Mouse
retina development in camera type eyeGO:00600411460.041
regulation of response to stimulusGO:00485832690.041
Human Mouse
smooth muscle contractionGO:000693920.040
oxoacid metabolic processGO:0043436310.038
Human Mouse
organic acid catabolic processGO:001605430.038
positive regulation of cellular amine metabolic processGO:003324000.038
Human
cell agingGO:000756920.037
heterocycle metabolic processGO:00464832900.037
Human Mouse
cell death in response to oxidative stressGO:003647320.037
Human Mouse
nucleoside monophosphate catabolic processGO:000912540.037
regulation of cellular amine metabolic processGO:003323800.036
Human
purine ribonucleoside monophosphate catabolic processGO:000916940.036
macromolecule biosynthetic processGO:00090592270.036
Human Mouse
action potentialGO:0001508190.036
regulation of developmental processGO:00507932470.036
regulation of blood pressureGO:000821710.035
cell type specific apoptotic processGO:0097285220.034
Human
microtubule based movementGO:0007018330.033
regulation of programmed cell deathGO:00430671010.033
Human Mouse
protein metabolic processGO:00195381830.033
Human Mouse
monoamine transportGO:001584410.033
Mouse
response to abiotic stimulusGO:00096281220.033
positive regulation of map kinase activityGO:004340630.032
atp catabolic processGO:000620040.031
response to oxygen levelsGO:0070482250.030
regulation of rho protein signal transductionGO:003502320.030
nucleic acid metabolic processGO:00903042440.030
Human Mouse
regulation of response to nutrient levelsGO:003210710.030
mitochondrion organizationGO:000700540.030
Mouse
fatty acid beta oxidationGO:000663510.030
cellular response to chemical stimulusGO:00708871570.029
Human Mouse
negative regulation of biological processGO:00485193040.029
Human Mouse
reactive oxygen species metabolic processGO:007259360.029
Human Mouse
purine nucleoside monophosphate catabolic processGO:000912840.028
regulation of oxidative stress induced cell deathGO:190320120.028
Human Mouse
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.028
maintenance of locationGO:005123540.027
lipid metabolic processGO:0006629520.027
cellular response to molecule of bacterial originGO:007121930.026
fatty acid oxidationGO:001939510.026
phosphorylationGO:0016310690.025
Human Mouse
nitric oxide metabolic processGO:004620920.025
regulation of nucleoside metabolic processGO:000911820.025
Human Mouse
regulation of membrane potentialGO:0042391230.025
Human Mouse
erythrocyte differentiationGO:0030218540.024
regulation of sarcomere organizationGO:006029720.024
leukocyte proliferationGO:007066110.024
negative regulation of oxidative stress induced cell deathGO:190320220.024
Human Mouse
cellular amine metabolic processGO:004410620.024
Human
homeostasis of number of cellsGO:0048872620.024
regulation of erk1 and erk2 cascadeGO:007037240.023
liver developmentGO:0001889960.023
response to copper ionGO:0046688130.023
regulation of apoptotic signaling pathwayGO:2001233120.023
Human Mouse
iron ion homeostasisGO:005507240.023
cellular response to reactive oxygen speciesGO:003461420.023
Human Mouse
positive regulation of nitrogen compound metabolic processGO:0051173690.022
Human Mouse
regulation of cellular carbohydrate metabolic processGO:001067540.021
cation transportGO:0006812810.021
Mouse
negative regulation of apoptotic processGO:0043066550.021
Human Mouse
cellular amino acid biosynthetic processGO:000865220.021
Human
cellular macromolecule biosynthetic processGO:00346452240.020
Human Mouse
neuron deathGO:0070997210.020
Human Mouse
regulation of anatomical structure sizeGO:0090066330.020
retrograde axon cargo transportGO:000809010.020
response to stressGO:00069502630.019
regulation of cellular amino acid metabolic processGO:000652100.019
Human
gland developmentGO:00487321430.019
sensory organ morphogenesisGO:00905962000.019
androgen metabolic processGO:000820920.019
negative regulation of cell communicationGO:0010648960.019
Human
regulation of biosynthetic processGO:00098892500.019
Human Mouse
negative regulation of intrinsic apoptotic signaling pathwayGO:200124380.019
Human
cellular aldehyde metabolic processGO:000608140.019
Human Mouse
regulation of signalingGO:00230512350.019
Human Mouse
light adaptionGO:003636710.019
axon cargo transportGO:000808820.019
response to activityGO:0014823140.018
response to oxygen containing compoundGO:1901700550.018
Human Mouse
transmission of nerve impulseGO:0019226190.018
cell morphogenesisGO:00009022890.018
regulation of blood vessel sizeGO:005088020.018
ion transportGO:00068111140.018
Mouse
nucleic acid templated transcriptionGO:00976591810.018
Human Mouse
negative regulation of cell deathGO:0060548600.018
Human Mouse
muscle structure developmentGO:00610611960.017
protein stabilizationGO:005082120.017
Human Mouse
cellular response to drugGO:003569010.017
negative regulation of dna metabolic processGO:005105340.017
locomotionGO:00400113130.017
heterocycle biosynthetic processGO:00181302150.017
Human Mouse
transcription dna templatedGO:00063511810.017
Human Mouse
negative regulation of metabolic processGO:0009892860.016
Human Mouse
response to decreased oxygen levelsGO:0036293250.016
intracellular mrna localizationGO:000829810.016
phosphorus metabolic processGO:00067931090.016
Human Mouse
regulation of developmental growthGO:0048638380.016
peptidyl serine phosphorylationGO:001810510.016
Human
response to woundingGO:00096111160.016
Mouse
deathGO:00162651210.015
Human Mouse
female sex differentiationGO:004666040.015
guanosine containing compound metabolic processGO:190106840.015
response to lipidGO:0033993600.015
Human
purine containing compound metabolic processGO:0072521290.015
Human Mouse
immune system processGO:00023762410.015
regulation of cytokine productionGO:000181730.015
Human
negative regulation of developmental processGO:0051093650.015
organic substance catabolic processGO:1901575280.015
Human Mouse
transportGO:00068102200.014
Human Mouse
response to temperature stimulusGO:0009266150.014
erk1 and erk2 cascadeGO:007037140.014
negative regulation of apoptotic signaling pathwayGO:2001234100.014
Human
regulation of ras gtpase activityGO:003231820.014
positive regulation of molecular functionGO:0044093330.014
Human Mouse
regulation of carbohydrate metabolic processGO:000610940.014
lipid oxidationGO:003444010.014
regulation of nitrogen compound metabolic processGO:00511712510.014
Human Mouse
multicellular organismal signalingGO:0035637220.014
myeloid cell homeostasisGO:0002262560.014
activation of mapk activityGO:000018730.014
regulation of neuron apoptotic processGO:0043523170.014
Human
regulation of dendrite developmentGO:005077330.013
embryonic organ developmentGO:00485683810.013
cell cell signalingGO:0007267520.013
Mouse
fat soluble vitamin biosynthetic processGO:004236220.013
regulation of gtpase activityGO:004308720.013
dopaminergic neuron differentiationGO:0071542140.013
ribosome assemblyGO:004225510.013
cation transmembrane transportGO:0098655650.013
regulation of rna biosynthetic processGO:20011412130.013
Human Mouse
xenobiotic metabolic processGO:000680540.013
positive regulation of cytokine productionGO:000181920.013
Human
purine nucleotide metabolic processGO:0006163270.013
Human Mouse
bleb assemblyGO:003206010.012
oxidative demethylationGO:007098910.012
response to dexamethasoneGO:007154810.012
cellular response to oxygen containing compoundGO:1901701200.012
Human Mouse
guanosine containing compound catabolic processGO:190106920.012
protein phosphorylationGO:0006468470.012
Human
heart developmentGO:00075073130.012
protein acetylationGO:000647320.011
Human
regulation of gtp catabolic processGO:003312420.011
hemopoiesisGO:00300971830.011
positive regulation of macromolecule metabolic processGO:0010604930.011
Human Mouse
alcohol biosynthetic processGO:004616520.011
Human Mouse
aromatic compound catabolic processGO:0019439150.011
regulation of response to biotic stimulusGO:000283120.011
regulation of cell differentiationGO:00455951420.011
negative regulation of dna replicationGO:000815620.011
extracellular matrix organizationGO:0030198270.011
regulation of systemic arterial blood pressureGO:000307310.011
reciprocal meiotic recombinationGO:000713110.011
neuron apoptotic processGO:0051402200.011
Human
energy reserve metabolic processGO:000611220.011
response to other organismGO:0051707970.010
regulation of tube sizeGO:003515020.010
nucleobase containing compound biosynthetic processGO:00346542050.010
Human Mouse
phosphate containing compound metabolic processGO:00067961080.010
Human Mouse
response to cadmium ionGO:0046686140.010
catabolic processGO:0009056320.010
Human Mouse
negative regulation of protein kinase activityGO:000646940.010
Human
negative regulation of multi organism processGO:004390130.010
carbon dioxide transportGO:001567030.010

park7 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of metabolismDOID:001466700.195
mitochondrial metabolism diseaseDOID:70000.195
inherited metabolic disorderDOID:65500.195
leigh diseaseDOID:365200.067
disease of anatomical entityDOID:700.032
Human
immune system diseaseDOID:291400.018
hematopoietic system diseaseDOID:7400.018
disease of cellular proliferationDOID:1456600.018
cancerDOID:16200.018
neurodegenerative diseaseDOID:128900.013
Human
central nervous system diseaseDOID:33100.013
Human
motor neuron diseaseDOID:23100.013
amyotrophic lateral sclerosisDOID:33200.013
nervous system diseaseDOID:86300.013
Human