Danio rerio

80 known processes

park2

Parkinson disease (autosomal recessive, juvenile) 2, parkin

(Aliases: zgc:112390,si:ch211-123f21.1)

park2 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.176
negative regulation of biological processGO:00485193040.121
agingGO:000756820.098
negative regulation of cellular processGO:00485232830.070
generation of neuronsGO:00486993850.061
cell part morphogenesisGO:00329902460.059
organic substance biosynthetic processGO:19015762890.059
neuron developmentGO:00486662620.057
cellular response to biotic stimulusGO:007121630.056
heterocycle metabolic processGO:00464832900.054
cellular nitrogen compound metabolic processGO:00346412900.054
nucleic acid metabolic processGO:00903042440.054
cellular macromolecule biosynthetic processGO:00346452240.053
response to chemicalGO:00422213200.050
response to drugGO:004249330.050
muscle cell developmentGO:00550011150.050
cellular component assemblyGO:00226071700.050
cell morphogenesisGO:00009022890.048
regulation of gene expressionGO:00104682650.047
immune system processGO:00023762410.045
maintenance of locationGO:005123540.044
gene expressionGO:00104672520.043
lipid storageGO:001991510.043
neuron differentiationGO:00301823530.043
regulation of protein transportGO:005122330.042
cellular component morphogenesisGO:00329893360.042
head developmentGO:00603223030.041
cell projection morphogenesisGO:00488582440.041
regulation of protein modification by small protein conjugation or removalGO:190332030.040
neuromuscular synaptic transmissionGO:000727420.040
positive regulation of transportGO:005105020.040
rna metabolic processGO:00160702190.040
organelle organizationGO:00069962270.039
response to organic substanceGO:00100331530.039
cellular amine metabolic processGO:004410620.039
negative regulation of protein phosphorylationGO:000193340.039
amine metabolic processGO:000930820.038
synaptic growth at neuromuscular junctionGO:005112420.038
phagocytosisGO:000690930.038
neuron projection developmentGO:00311751800.038
striated muscle cell differentiationGO:00511461290.037
nucleobase containing compound metabolic processGO:00061392740.037
cell projection organizationGO:00300302840.037
carboxylic acid metabolic processGO:0019752220.037
digestive system developmentGO:00551232890.037
morphogenesis of an epitheliumGO:00020093330.037
adult behaviorGO:003053420.037
response to stressGO:00069502630.036
regulation of biosynthetic processGO:00098892500.035
nitrogen compound metabolic processGO:00068073190.035
stem cell proliferationGO:007208940.035
regulation of protein catabolic processGO:004217610.035
cellular response to external stimulusGO:007149620.035
regulation of establishment of protein localizationGO:007020140.035
regulation of cellular biosynthetic processGO:00313262450.035
regulation of metal ion transportGO:001095940.034
regulation of cellular metabolic processGO:00313233200.034
regulation of rna biosynthetic processGO:20011412130.034
multicellular organism growthGO:003526440.034
cellular biosynthetic processGO:00442492860.033
cellular nitrogen compound biosynthetic processGO:00442712180.033
organic acid metabolic processGO:0006082310.033
establishment of protein localization to organelleGO:007259440.033
proteasomal protein catabolic processGO:001049820.033
single organism metabolic processGO:00447102170.033
single organism organelle organizationGO:19025891990.033
eye developmentGO:00016542770.033
regulation of synapse assemblyGO:005196330.033
embryonic organ developmentGO:00485683810.033
regulation of intracellular protein transportGO:003315730.032
biosynthetic processGO:00090582940.032
fatty acid biosynthetic processGO:000663340.032
vasculature developmentGO:00019442780.032
protein metabolic processGO:00195381830.032
blood vessel developmentGO:00015682460.031
regulation of cellular amine metabolic processGO:003323800.031
regulation of dna replicationGO:000627530.031
sensory organ developmentGO:00074233930.030
cellular protein catabolic processGO:004425740.030
axonogenesisGO:00074091520.030
cellular component biogenesisGO:00440851780.030
single organism localizationGO:19025782250.030
regulation of biological qualityGO:00650082630.030
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.030
proteolysis involved in cellular protein catabolic processGO:005160330.030
regulation of cellular macromolecule biosynthetic processGO:20001122220.030
sensory organ morphogenesisGO:00905962000.029
nucleocytoplasmic transportGO:000691340.029
organelle assemblyGO:00709251100.029
regulation of multicellular organismal processGO:00512392770.029
nuclear transportGO:005116940.029
regulation of cellular ketone metabolic processGO:001056570.029
negative regulation of protein transportGO:005122430.029
neuroblast proliferationGO:000740520.029
organic cyclic compound biosynthetic processGO:19013622230.029
small molecule metabolic processGO:0044281770.029
regulation of inflammatory responseGO:005072720.029
liver developmentGO:0001889960.028
regulation of cellular amino acid metabolic processGO:000652100.028
cytokinesisGO:000091030.028
blood vessel morphogenesisGO:00485142160.028
regulation of rna metabolic processGO:00512522240.028
post embryonic organ developmentGO:004856940.028
protein localization to nucleusGO:003450430.028
central nervous system developmentGO:00074173870.028
oxoacid metabolic processGO:0043436310.028
regulation of neural precursor cell proliferationGO:200017730.027
regulation of nucleic acid templated transcriptionGO:19035062130.027
cellular aromatic compound metabolic processGO:00067252950.027
regulation of developmental processGO:00507932470.027
regulation of synapse organizationGO:005080730.027
modification dependent macromolecule catabolic processGO:004363230.027
response to abiotic stimulusGO:00096281220.027
regulation of transcription dna templatedGO:00063552130.027
regulation of cytokine productionGO:000181730.027
cilium morphogenesisGO:0060271850.027
cellular component movementGO:00069283350.027
striated muscle cell developmentGO:00550021080.027
regulation of synaptic growth at neuromuscular junctionGO:000858210.026
organic cyclic compound metabolic processGO:19013603010.026
establishment of localizationGO:00512342440.026
regulation of macromolecule metabolic processGO:00602553170.026
nucleobase containing compound biosynthetic processGO:00346542050.026
cellular amino acid metabolic processGO:000652070.026
long chain fatty acid metabolic processGO:000167610.026
nuclear importGO:005117030.026
regulation of nucleobase containing compound metabolic processGO:00192192500.026
regulation of nucleocytoplasmic transportGO:004682220.026
regulation of metabolic processGO:00192223590.026
cellular macromolecule metabolic processGO:00442603910.026
positive regulation of epithelial cell proliferationGO:005067910.025
regulation of multicellular organism growthGO:004001440.025
regulation of stem cell proliferationGO:007209120.025
regulation of protein targetingGO:190353320.025
organonitrogen compound metabolic processGO:1901564740.025
cellular response to lipopolysaccharideGO:007122230.025
regulation of protein localization to nucleusGO:190018020.025
negative regulation of protein kinase activityGO:000646940.025
positive regulation of biological processGO:00485182530.025
rna biosynthetic processGO:00327741810.025
transcription dna templatedGO:00063511810.024
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.024
macromolecular complex subunit organizationGO:0043933740.024
transcription from rna polymerase ii promoterGO:0006366800.024
protein importGO:001703830.024
single organism nuclear importGO:190259330.024
negative regulation of catabolic processGO:000989530.024
cell morphogenesis involved in neuron differentiationGO:00486671630.023
brain developmentGO:00074202930.023
programmed cell deathGO:00125011190.023
transportGO:00068102200.023
positive regulation of cell cycleGO:004578730.023
heterocycle biosynthetic processGO:00181302150.023
guanosine containing compound metabolic processGO:190106840.023
mitochondrion organizationGO:000700540.023
locomotionGO:00400113130.023
positive regulation of dna metabolic processGO:005105410.023
positive regulation of cellular amine metabolic processGO:003324000.023
neuron projection morphogenesisGO:00488121610.023
protein targeting to nucleusGO:004474430.023
regulation of protein import into nucleusGO:004230620.022
cellular ketone metabolic processGO:0042180110.022
cellular response to extracellular stimulusGO:003166820.022
regulation of cytoplasmic transportGO:190364940.022
cognitionGO:005089010.022
multi organism processGO:00517041340.022
response to glucoseGO:000974930.021
cellular response to nutrient levelsGO:003166920.021
response to uvGO:000941130.021
regulation of circadian rhythmGO:004275240.021
regulation of calcium ion transportGO:005192420.021
camera type eye developmentGO:00430102220.021
regulation of primary metabolic processGO:00800903110.021
regulation of bindingGO:005109830.021
regulation of protein complex assemblyGO:004325430.020
purine ribonucleoside monophosphate catabolic processGO:000916940.020
hepaticobiliary system developmentGO:0061008980.020
nucleic acid templated transcriptionGO:00976591810.020
cellular response to chemical stimulusGO:00708871570.020
response to hexoseGO:000974630.020
neuron neuron synaptic transmissionGO:000727010.020
response to endogenous stimulusGO:0009719830.020
response to corticosteroidGO:003196010.020
cellular response to molecule of bacterial originGO:007121930.020
regulation of macromolecule biosynthetic processGO:00105562250.020
positive regulation of secretionGO:005104710.020
negative regulation of protein localization to nucleusGO:190018120.020
secondary metabolic processGO:001974830.019
developmental growthGO:00485891660.019
stem cell divisionGO:001714510.019
regulation of cell activationGO:005086510.019
regulation of protein ubiquitinationGO:003139630.019
phosphate containing compound metabolic processGO:00067961080.019
response to glucocorticoidGO:005138410.019
startle responseGO:000196440.019
regulation of nitrogen compound metabolic processGO:00511712510.019
hematopoietic or lymphoid organ developmentGO:00485341910.019
response to monosaccharideGO:003428430.019
ubiquitin dependent protein catabolic processGO:000651130.019
negative regulation of cytoplasmic transportGO:190365020.019
determination of bilateral symmetryGO:00098552040.019
regulation of synaptic plasticityGO:004816710.019
digestive tract morphogenesisGO:00485462310.019
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.019
peptide transportGO:001583310.018
positive regulation of cytokine productionGO:000181920.018
circulatory system processGO:0003013870.018
protein modification processGO:00362111000.018
embryonic organ morphogenesisGO:00485622740.018
positive regulation of secretion by cellGO:190353210.018
growthGO:00400071740.018
organelle fusionGO:004828430.018
negative regulation of autophagyGO:001050710.018
digestive tract developmentGO:00485652650.018
protein import into nucleusGO:000660630.018
determination of left right symmetryGO:00073681790.018
transmembrane transportGO:00550851200.018
convergent extensionGO:00600261180.018
regulation of reproductive processGO:200024140.018
guanosine containing compound catabolic processGO:190106920.018
gastrulationGO:00073692080.018
regulation of muscle contractionGO:000693730.018
cellular carbohydrate metabolic processGO:004426240.018
interspecies interaction between organismsGO:004441940.018
angiogenesisGO:00015251580.018
muscle cell differentiationGO:00426921390.018
system processGO:00030081850.018
cellular response to starvationGO:000926710.018
response to external stimulusGO:00096052640.018
cellular component assembly involved in morphogenesisGO:00109271070.017
negative regulation of kinase activityGO:003367340.017
carbohydrate homeostasisGO:003350010.017
stem cell maintenanceGO:001982740.017
signal transductionGO:00071654550.017
protein localization to plasma membraneGO:007265910.017
negative regulation of nucleocytoplasmic transportGO:004682320.017
positive regulation of cellular amino acid metabolic processGO:004576400.017
spermatid developmentGO:000728620.017
autophagyGO:000691440.017
negative regulation of gene expressionGO:0010629650.017
homeostatic processGO:00425921420.017
single organism transportGO:00447652060.017
spermatid differentiationGO:004851520.017
determination of heart left right asymmetryGO:00613711170.017
regulation of meiotic cell cycleGO:005144510.017
macromolecule biosynthetic processGO:00090592270.016
gtp metabolic processGO:004603940.016
response to woundingGO:00096111160.016
muscle structure developmentGO:00610611960.016
gtp catabolic processGO:000618420.016
response to carbohydrateGO:000974330.016
specification of symmetryGO:00097992040.016
negative regulation of intracellular transportGO:003238730.016
negative regulation of mapk cascadeGO:004340940.016
symbiosis encompassing mutualism through parasitismGO:004440340.016
inorganic cation transmembrane transportGO:0098662500.016
inner ear developmentGO:00488391260.016
heart developmentGO:00075073130.016
negative regulation of cellular catabolic processGO:003133030.016
ear developmentGO:00435831270.016
protein stabilizationGO:005082120.016
aromatic compound biosynthetic processGO:00194382170.016
regulation of protein bindingGO:004339330.015
regulation of epithelial cell proliferationGO:005067830.015
b cell mediated immunityGO:001972430.015
nuclear exportGO:005116810.015
synaptic transmission cholinergicGO:000727140.015
regulation of dendrite developmentGO:005077330.015
cellular response to hypoxiaGO:007145610.015
positive regulation of cellular catabolic processGO:003133130.015
tube morphogenesisGO:00352393490.015
regulation of autophagyGO:001050630.015
cellular protein metabolic processGO:00442671290.015
lymphocyte proliferationGO:004665110.015
alpha amino acid metabolic processGO:190160530.015
cation transmembrane transportGO:0098655650.015
anion transportGO:0006820380.015
positive regulation of catabolic processGO:000989640.015
regulation of signal transductionGO:00099662250.015
astrocyte differentiationGO:004870810.015
regulation of cellular component organizationGO:0051128860.015
exocytosisGO:000688710.015
glucose homeostasisGO:004259310.015
membrane fusionGO:006102520.015
transmission of nerve impulseGO:0019226190.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.014
neurological system processGO:0050877620.014
establishment of endothelial barrierGO:006102830.014
negative regulation of macromolecule metabolic processGO:0010605760.014
response to transition metal nanoparticleGO:1990267280.014
regulation of reactive oxygen species metabolic processGO:200037720.014
negative regulation of secretionGO:005104820.014
negative regulation of apoptotic processGO:0043066550.014
mononuclear cell proliferationGO:003294310.014
hormone secretionGO:004687920.014
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.014
axon extensionGO:0048675450.014
cell substrate adhesionGO:003158940.014
blood circulationGO:0008015870.014
regulation of signalingGO:00230512350.014
axon developmentGO:00615641660.014
cellular response to organic substanceGO:00713101050.014
inorganic ion transmembrane transportGO:0098660570.014
regulation of peptidyl tyrosine phosphorylationGO:005073010.014
behaviorGO:0007610740.014
taxisGO:00423301090.014
single organism membrane fusionGO:004480120.014
reactive oxygen species biosynthetic processGO:190340910.014
regulation of hormone secretionGO:004688320.014
regulation of multicellular organismal developmentGO:20000262230.014
reactive nitrogen species metabolic processGO:200105700.013
positive regulation of cellular component biogenesisGO:004408930.013
action potentialGO:0001508190.013
cytoskeleton dependent cytokinesisGO:006164030.013
protein acylationGO:004354330.013
regulation of response to stimulusGO:00485832690.013
organic anion transportGO:0015711150.013
regulation of erk1 and erk2 cascadeGO:007037240.013
cell morphogenesis involved in differentiationGO:00009041950.013
regulation of carbohydrate metabolic processGO:000610940.013
cellular component disassemblyGO:002241110.013
dorsal ventral pattern formationGO:00099531250.013
regulation of cell shapeGO:000836010.013
regulation of membrane potentialGO:0042391230.013
mitotic dna damage checkpointGO:004477340.013
negative regulation of epithelial cell proliferationGO:005068010.013
embryonic hemopoiesisGO:0035162530.013
positive regulation of cell activationGO:005086710.013
cellular response to reactive oxygen speciesGO:003461420.013
response to hydrogen peroxideGO:004254230.013
cellular protein modification processGO:00064641000.013
retina development in camera type eyeGO:00600411460.013
response to biotic stimulusGO:0009607970.013
synaptic vesicle localizationGO:009747910.013
purine nucleoside monophosphate catabolic processGO:000912840.013
regulation of cell communicationGO:00106462320.013
toll like receptor signaling pathwayGO:000222440.013
nucleoside monophosphate catabolic processGO:000912540.013
phagocytosis engulfmentGO:000691110.013
protein homooligomerizationGO:005126030.013
embryo development ending in birth or egg hatchingGO:00097922710.013
defense responseGO:0006952470.013
rna localizationGO:000640340.013
regulation of i kappab kinase nf kappab signalingGO:004312240.013
i kappab kinase nf kappab signalingGO:000724940.013
positive regulation of lipid metabolic processGO:004583410.013
developmental growth involved in morphogenesisGO:0060560860.013
regulation of transcription from rna polymerase ii promoterGO:00063571140.013
negative regulation of intracellular protein transportGO:009031730.013
atp catabolic processGO:000620040.013
multicellular organismal signalingGO:0035637220.013
negative regulation of protein import into nucleusGO:004230820.013
microtubule based processGO:0007017600.013
energy reserve metabolic processGO:000611220.013
immune system developmentGO:00025201910.012
regulation of cellular carbohydrate metabolic processGO:001067540.012
viral processGO:001603210.012
cell cell signalingGO:0007267520.012
ear morphogenesisGO:0042471640.012
carboxylic acid catabolic processGO:004639530.012
cellular response to oxygen levelsGO:007145310.012
cellular respirationGO:004533330.012
multi organism cellular processGO:004476420.012
response to nutrientGO:000758430.012
leukocyte proliferationGO:007066110.012
protein complex subunit organizationGO:0071822460.012
ion transmembrane transportGO:0034220910.012
immunoglobulin mediated immune responseGO:001606430.012
positive regulation of cellular processGO:00485222010.012
neuromast developmentGO:0048884460.012
gland developmentGO:00487321430.012
deathGO:00162651210.012
negative regulation of cellular metabolic processGO:0031324770.012
b cell activationGO:004211320.012
heart contractionGO:0060047710.012
negative regulation of multi organism processGO:004390130.012
regulation of programmed cell deathGO:00430671010.012
regulation of tube sizeGO:003515020.011
post embryonic morphogenesisGO:000988640.011
microtubule based movementGO:0007018330.011
compound eye developmentGO:004874920.011
negative regulation of defense responseGO:003134820.011
epithelial cell differentiationGO:00308551160.011
chordate embryonic developmentGO:00430092710.011
regulation of mrna splicing via spliceosomeGO:004802430.011
modification dependent protein catabolic processGO:001994130.011
regulation of response to nutrient levelsGO:003210710.011
cell migrationGO:00164772370.011
cilium assemblyGO:0042384580.011
positive regulation of apoptotic signaling pathwayGO:200123510.011
cell surface receptor signaling pathwayGO:00071663250.011
protein acetylationGO:000647320.011
regulation of striated muscle contractionGO:000694220.011
lipid homeostasisGO:005508830.011
intracellular signal transductionGO:0035556850.011
positive regulation of metabolic processGO:00098931080.011
macromolecular complex assemblyGO:0065003350.011
negative regulation of programmed cell deathGO:0043069580.011
organic acid catabolic processGO:001605430.011
peptidyl serine modificationGO:001820920.011
mitotic dna integrity checkpointGO:004477440.011
regulation of extrinsic apoptotic signaling pathway in absence of ligandGO:200123910.011
peptide metabolic processGO:000651810.011
cell migration involved in gastrulationGO:0042074790.011
chemotaxisGO:00069351040.011
regulation of organelle assemblyGO:190211540.011
developmental cell growthGO:0048588520.011
alcohol biosynthetic processGO:004616520.011
protein complex localizationGO:003150310.011
meiotic nuclear divisionGO:000712640.011
regulation of cellular protein catabolic processGO:190336210.011
hormone transportGO:000991420.011
hemopoiesisGO:00300971830.011
cellular response to radiationGO:007147840.011
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.011
regulation of extrinsic apoptotic signaling pathwayGO:200123630.011
somatic muscle developmentGO:000752540.011
positive regulation of protein kinase b signalingGO:005189710.011
positive regulation of neuron deathGO:190121610.011
regulation of dna templated transcription in response to stressGO:004362000.011
monovalent inorganic cation transportGO:0015672420.011
multicellular organismal metabolic processGO:004423620.011
protein dephosphorylationGO:000647030.011
peptidyl serine phosphorylationGO:001810510.011
cellular response to decreased oxygen levelsGO:003629410.011
nitric oxide metabolic processGO:004620920.011
cell deathGO:00082191210.011
muscle fiber developmentGO:0048747520.011
apoptotic processGO:00069151160.011
axon guidanceGO:0007411860.011
regulation of microtubule cytoskeleton organizationGO:007050730.010
posterior lateral line system developmentGO:0048915460.010
extrinsic apoptotic signaling pathwayGO:009719130.010
regulation of postsynaptic membrane potentialGO:006007810.010
response to alkaloidGO:004327920.010
peripheral nervous system developmentGO:0007422550.010
regionalizationGO:00030022740.010
regulation of cardiac muscle contractionGO:005511720.010
peptidyl lysine acetylationGO:001839420.010
regulation of localizationGO:00328791040.010
negative regulation of neural precursor cell proliferationGO:200017810.010
regulation of cell deathGO:00109411030.010
regulation of nucleoside metabolic processGO:000911820.010
sensory perception of painGO:001923310.010
cell cycle g1 s phase transitionGO:004484310.010
macromolecular complex disassemblyGO:003298410.010
regulation of transporter activityGO:003240920.010
positive regulation of stem cell proliferationGO:200064810.010
cellular response to lipidGO:0071396390.010
positive regulation of synapse assemblyGO:005196510.010
regulation of nucleotide catabolic processGO:003081120.010
phosphorylationGO:0016310690.010
organic substance transportGO:0071702580.010
camera type eye morphogenesisGO:00485931080.010
pigmentationGO:0043473850.010
response to metal ionGO:0010038340.010
negative regulation of extrinsic apoptotic signaling pathwayGO:200123720.010
cellular response to stressGO:0033554620.010

park2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.064
nervous system diseaseDOID:86300.039
cancerDOID:16200.021
disease of cellular proliferationDOID:1456600.021
organ system cancerDOID:005068600.021
disease of metabolismDOID:001466700.017
eye and adnexa diseaseDOID:149200.013
sensory system diseaseDOID:005015500.013
inherited metabolic disorderDOID:65500.012
musculoskeletal system diseaseDOID:1700.011
eye diseaseDOID:561400.010