Danio rerio

36 known processes

cul4a

cullin 4A

(Aliases: zgc:64071,MGC64071)

cul4a biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.111
central nervous system developmentGO:00074173870.068
biosynthetic processGO:00090582940.060
cognitionGO:005089010.057
cellular biosynthetic processGO:00442492860.055
nitrogen compound metabolic processGO:00068073190.055
heterocycle metabolic processGO:00464832900.053
organic cyclic compound metabolic processGO:19013603010.053
nucleobase containing compound metabolic processGO:00061392740.053
sensory organ developmentGO:00074233930.052
cellular macromolecule metabolic processGO:00442603910.052
positive regulation of transportGO:005105020.050
cellular aromatic compound metabolic processGO:00067252950.050
signal transductionGO:00071654550.050
agingGO:000756820.049
cellular nitrogen compound metabolic processGO:00346412900.049
regulation of nitrogen compound metabolic processGO:00511712510.045
cellular response to external stimulusGO:007149620.045
multicellular organism growthGO:003526440.045
embryonic organ developmentGO:00485683810.044
cellular protein catabolic processGO:004425740.044
regulation of metabolic processGO:00192223590.044
response to chemicalGO:00422213200.043
proteolysis involved in cellular protein catabolic processGO:005160330.042
maintenance of locationGO:005123540.042
nucleobase containing compound biosynthetic processGO:00346542050.041
brain developmentGO:00074202930.041
organic cyclic compound biosynthetic processGO:19013622230.040
regulation of establishment of protein localizationGO:007020140.040
establishment of localizationGO:00512342440.040
rna biosynthetic processGO:00327741810.039
cellular macromolecule biosynthetic processGO:00346452240.039
mitochondrion organizationGO:000700540.039
regulation of protein complex assemblyGO:004325430.039
eye developmentGO:00016542770.039
positive regulation of cellular catabolic processGO:003133130.039
establishment of protein localization to organelleGO:007259440.039
phagocytosisGO:000690930.038
neuron differentiationGO:00301823530.037
organic substance biosynthetic processGO:19015762890.037
positive regulation of catabolic processGO:000989640.037
regulation of primary metabolic processGO:00800903110.037
rna metabolic processGO:00160702190.037
regulation of metal ion transportGO:001095940.037
regulation of macromolecule metabolic processGO:00602553170.037
head developmentGO:00603223030.037
positive regulation of cell cycleGO:004578730.036
morphogenesis of an epitheliumGO:00020093330.036
regulation of protein catabolic processGO:004217610.036
generation of neuronsGO:00486993850.036
cellular nitrogen compound biosynthetic processGO:00442712180.036
ubiquitin dependent protein catabolic processGO:000651130.036
regulation of synaptic plasticityGO:004816710.036
autophagyGO:000691440.036
single organism localizationGO:19025782250.035
regulation of protein transportGO:005122330.035
modification dependent protein catabolic processGO:001994130.034
proteasomal protein catabolic processGO:001049820.034
regulation of response to stimulusGO:00485832690.034
cellular amine metabolic processGO:004410620.033
modification dependent macromolecule catabolic processGO:004363230.033
cellular response to starvationGO:000926710.033
nucleic acid templated transcriptionGO:00976591810.033
regulation of multicellular organismal processGO:00512392770.032
macromolecule biosynthetic processGO:00090592270.031
golgi vesicle transportGO:004819330.031
regulation of protein targetingGO:190353320.031
negative regulation of biological processGO:00485193040.031
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.031
single organism membrane fusionGO:004480120.031
regulation of cell communicationGO:00106462320.031
cellular component morphogenesisGO:00329893360.030
regulation of rna biosynthetic processGO:20011412130.030
regulation of multicellular organism growthGO:004001440.030
regulation of cellular biosynthetic processGO:00313262450.030
negative regulation of protein phosphorylationGO:000193340.030
aromatic compound biosynthetic processGO:00194382170.030
organelle fusionGO:004828430.030
single organism transportGO:00447652060.030
regulation of gene expressionGO:00104682650.030
digestive tract developmentGO:00485652650.029
response to external stimulusGO:00096052640.029
regulation of bindingGO:005109830.029
regulation of biosynthetic processGO:00098892500.029
nuclear transportGO:005116940.029
nucleocytoplasmic transportGO:000691340.029
regulation of macromolecule biosynthetic processGO:00105562250.029
transcription dna templatedGO:00063511810.029
amine metabolic processGO:000930820.029
regulation of cellular macromolecule biosynthetic processGO:20001122220.029
regulation of biological qualityGO:00650082630.028
gene expressionGO:00104672520.028
cell surface receptor signaling pathwayGO:00071663250.028
single organism organelle organizationGO:19025891990.028
regulation of developmental processGO:00507932470.028
adult behaviorGO:003053420.028
cellular response to extracellular stimulusGO:003166820.028
cell morphogenesisGO:00009022890.028
membrane fusionGO:006102520.028
protein localization to plasma membraneGO:007265910.028
lipid storageGO:001991510.028
gtp catabolic processGO:000618420.028
stem cell maintenanceGO:001982740.027
regulation of rna metabolic processGO:00512522240.027
embryonic organ morphogenesisGO:00485622740.027
regulation of muscle contractionGO:000693730.027
cell part morphogenesisGO:00329902460.027
regulation of transcription dna templatedGO:00063552130.027
guanosine containing compound catabolic processGO:190106920.027
response to alkaloidGO:004327920.027
regulation of nucleic acid templated transcriptionGO:19035062130.027
single organism metabolic processGO:00447102170.027
tube morphogenesisGO:00352393490.027
sensory organ morphogenesisGO:00905962000.027
transportGO:00068102200.027
digestive system developmentGO:00551232890.027
cellular component movementGO:00069283350.026
regulation of signalingGO:00230512350.026
cellular response to nutrient levelsGO:003166920.026
protein targeting to nucleusGO:004474430.026
synaptic vesicle localizationGO:009747910.026
stem cell proliferationGO:007208940.026
positive regulation of cellular component biogenesisGO:004408930.026
small molecule metabolic processGO:0044281770.026
meiotic nuclear divisionGO:000712640.026
neuron developmentGO:00486662620.025
gtp metabolic processGO:004603940.025
locomotionGO:00400113130.025
regulation of cellular metabolic processGO:00313233200.025
negative regulation of cellular processGO:00485232830.025
regulation of nucleobase containing compound metabolic processGO:00192192500.025
peptidyl serine phosphorylationGO:001810510.025
nucleic acid metabolic processGO:00903042440.025
cell projection morphogenesisGO:00488582440.025
cytokinesisGO:000091030.025
guanosine containing compound metabolic processGO:190106840.025
heart developmentGO:00075073130.024
regulation of cell activationGO:005086510.024
response to carbohydrateGO:000974330.024
response to drugGO:004249330.024
regulation of intracellular protein transportGO:003315730.024
cellular carbohydrate metabolic processGO:004426240.024
protein importGO:001703830.024
regulation of cytokine productionGO:000181730.024
hepaticobiliary system developmentGO:0061008980.024
system processGO:00030081850.023
organonitrogen compound metabolic processGO:1901564740.023
single organism nuclear importGO:190259330.023
immune system processGO:00023762410.023
positive regulation of protein complex assemblyGO:003133420.023
regulation of nucleocytoplasmic transportGO:004682220.023
actin polymerization or depolymerizationGO:000815420.023
response to topologically incorrect proteinGO:003596620.023
positive regulation of biological processGO:00485182530.023
cell projection organizationGO:00300302840.023
regulation of signal transductionGO:00099662250.022
synaptic vesicle transportGO:004848910.022
endosomal transportGO:001619720.022
specification of symmetryGO:00097992040.022
organic acid metabolic processGO:0006082310.022
heterocycle biosynthetic processGO:00181302150.022
liver developmentGO:0001889960.022
regulation of protein modification by small protein conjugation or removalGO:190332030.022
hematopoietic or lymphoid organ developmentGO:00485341910.022
negative regulation of kinase activityGO:003367340.022
positive regulation of secretionGO:005104710.022
gastrulationGO:00073692080.022
regulation of cellular amine metabolic processGO:003323800.022
chordate embryonic developmentGO:00430092710.022
regulation of cytoplasmic transportGO:190364940.022
protein localization to nucleusGO:003450430.022
gland developmentGO:00487321430.022
cellular response to chemical stimulusGO:00708871570.022
cell substrate adhesionGO:003158940.022
exocytosisGO:000688710.022
i kappab kinase nf kappab signalingGO:000724940.022
membrane invaginationGO:001032410.021
response to organic substanceGO:00100331530.021
cellular ketone metabolic processGO:0042180110.021
hormone secretionGO:004687920.021
regulation of protein ubiquitinationGO:003139630.021
response to monosaccharideGO:003428430.021
phagocytosis engulfmentGO:000691110.021
nuclear importGO:005117030.021
protein polymerizationGO:005125840.021
regulation of cellular amino acid metabolic processGO:000652100.021
regionalizationGO:00030022740.021
response to uvGO:000941130.020
negative regulation of protein kinase activityGO:000646940.020
positive regulation of cytokine productionGO:000181920.020
regulation of programmed cell deathGO:00430671010.020
embryo development ending in birth or egg hatchingGO:00097922710.020
antimicrobial humoral responseGO:001973020.020
regulation of mrna processingGO:005068430.020
ear developmentGO:00435831270.020
regulation of i kappab kinase nf kappab signalingGO:004312240.020
transcription from rna polymerase ii promoterGO:0006366800.020
organelle organizationGO:00069962270.020
regulation of apoptotic processGO:0042981980.020
regulation of synapse organizationGO:005080730.020
peptide transportGO:001583310.020
regulation of autophagyGO:001050630.020
macroautophagyGO:001623610.020
determination of left right symmetryGO:00073681790.020
oxoacid metabolic processGO:0043436310.020
positive regulation of secretion by cellGO:190353210.020
protein metabolic processGO:00195381830.020
carboxylic acid metabolic processGO:0019752220.019
regulation of protein polymerizationGO:003227120.019
regulation of multicellular organismal developmentGO:20000262230.019
cell migrationGO:00164772370.019
cell matrix adhesionGO:000716040.019
protein secretionGO:000930610.019
digestive tract morphogenesisGO:00485462310.019
vasculature developmentGO:00019442780.019
regulation of cell deathGO:00109411030.019
carbohydrate homeostasisGO:003350010.019
cell motilityGO:00488702440.019
response to hexoseGO:000974630.018
peptidyl serine modificationGO:001820920.018
microtubule organizing center organizationGO:003102310.018
protein dephosphorylationGO:000647030.018
pigment granule localizationGO:0051875250.018
regulation of cellular ketone metabolic processGO:001056570.018
cilium morphogenesisGO:0060271850.018
centrosome organizationGO:005129710.018
hemopoiesisGO:00300971830.018
spermatid developmentGO:000728620.018
cell deathGO:00082191210.018
extrinsic apoptotic signaling pathwayGO:009719130.018
regulation of cell shapeGO:000836010.018
establishment of localization in cellGO:0051649770.018
regulation of circadian rhythmGO:004275240.018
cellular response to radiationGO:007147840.018
compound eye developmentGO:004874920.018
homeostatic processGO:00425921420.018
regulation of stem cell proliferationGO:007209120.018
cellular amino acid metabolic processGO:000652070.018
camera type eye developmentGO:00430102220.018
negative regulation of metabolic processGO:0009892860.017
positive regulation of cytoskeleton organizationGO:005149530.017
regulation of transcription from rna polymerase ii promoterGO:00063571140.017
positive regulation of i kappab kinase nf kappab signalingGO:004312330.017
regulation of protein localization to nucleusGO:190018020.017
cilium organizationGO:0044782710.017
neuroblast proliferationGO:000740520.017
negative regulation of protein transportGO:005122430.017
development of primary female sexual characteristicsGO:004654540.017
hormone transportGO:000991420.017
regulation of protein bindingGO:004339330.017
regulation of protein import into nucleusGO:004230620.017
positive regulation of cell adhesionGO:004578510.017
startle responseGO:000196440.017
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.017
regulation of purine nucleotide catabolic processGO:003312120.016
actin filament polymerizationGO:003004120.016
regulation of gtp catabolic processGO:003312420.016
synaptic growth at neuromuscular junctionGO:005112420.016
cell cycle g1 s phase transitionGO:004484310.016
regulation of nucleotide catabolic processGO:003081120.016
cellular protein metabolic processGO:00442671290.016
regulation of nucleoside metabolic processGO:000911820.016
regulation of extrinsic apoptotic signaling pathwayGO:200123630.016
rna localizationGO:000640340.016
immune system developmentGO:00025201910.016
cellular component biogenesisGO:00440851780.016
meiotic cell cycle processGO:190304630.016
apoptotic processGO:00069151160.016
negative regulation of nitrogen compound metabolic processGO:0051172590.016
regulation of synapse assemblyGO:005196330.016
cellular component assemblyGO:00226071700.016
secondary metabolic processGO:001974830.016
regulation of cell developmentGO:00602841000.016
glucose homeostasisGO:004259310.015
inner ear developmentGO:00488391260.015
localization of cellGO:00516742440.015
negative regulation of protein complex assemblyGO:003133310.015
regulation of organelle assemblyGO:190211540.015
heart processGO:0003015710.015
regulation of cellular component organizationGO:0051128860.015
negative regulation of cell deathGO:0060548600.015
neurological system processGO:0050877620.015
positive regulation of cellular processGO:00485222010.015
cellular response to biotic stimulusGO:007121630.015
regulation of calcium ion transportGO:005192420.015
negative regulation of macromolecule metabolic processGO:0010605760.015
cellular response to topologically incorrect proteinGO:003596720.015
eye morphogenesisGO:00485921440.015
determination of bilateral symmetryGO:00098552040.015
cellular response to molecule of bacterial originGO:007121930.015
sleepGO:003043110.015
female sex differentiationGO:004666040.015
urogenital system developmentGO:0001655970.015
cellular localizationGO:0051641970.015
protein modification processGO:00362111000.015
regulation of anatomical structure morphogenesisGO:00226031300.015
cellular response to light stimulusGO:007148240.015
protein import into nucleusGO:000660630.015
establishment of vesicle localizationGO:0051650240.015
regulation of mrna splicing via spliceosomeGO:004802430.015
forebrain cell migrationGO:002188510.015
regulation of cell substrate adhesionGO:001081010.015
cellular response to lipopolysaccharideGO:007122230.015
developmental growthGO:00485891660.015
regulation of reproductive processGO:200024140.015
positive regulation of apoptotic signaling pathwayGO:200123510.015
deathGO:00162651210.015
regulation of localizationGO:00328791040.015
phosphate containing compound metabolic processGO:00067961080.014
regulation of cell differentiationGO:00455951420.014
retina development in camera type eyeGO:00600411460.014
organelle assemblyGO:00709251100.014
establishment of synaptic vesicle localizationGO:009748010.014
neuron projection morphogenesisGO:00488121610.014
macromolecule modificationGO:00434121110.014
regulation of reactive oxygen species metabolic processGO:200037720.014
intracellular signal transductionGO:0035556850.014
cellular component assembly involved in morphogenesisGO:00109271070.014
cellular response to organic substanceGO:00713101050.014
regulation of cellular carbohydrate metabolic processGO:001067540.014
regulation of transmembrane transporter activityGO:002289820.014
response to stressGO:00069502630.014
regulation of cellular protein catabolic processGO:190336210.014
neurotransmitter transportGO:000683620.014
response to glucoseGO:000974930.014
regulation of neurogenesisGO:0050767870.014
organelle localizationGO:0051640490.014
translational initiationGO:000641330.014
regulation of neural precursor cell proliferationGO:200017730.014
regulation of wound healingGO:006104120.014
cellular pigmentationGO:0033059300.014
positive regulation of map kinase activityGO:004340630.014
spermatid differentiationGO:004851520.014
cellular response to reactive oxygen speciesGO:003461420.014
neuron neuron synaptic transmissionGO:000727010.014
camera type eye morphogenesisGO:00485931080.014
response to hydrogen peroxideGO:004254230.014
regulation of meiotic cell cycleGO:005144510.014
regulation of carbohydrate metabolic processGO:000610940.014
internal protein amino acid acetylationGO:000647520.014
positive regulation of cell activationGO:005086710.014
cellular component disassemblyGO:002241110.014
g1 s transition of mitotic cell cycleGO:000008210.014
blood vessel developmentGO:00015682460.014
endoplasmic reticulum unfolded protein responseGO:003096820.014
negative regulation of catabolic processGO:000989530.014
mitotic dna integrity checkpointGO:004477440.014
regulation of transporter activityGO:003240920.014
blood vessel morphogenesisGO:00485142160.014
positive regulation of nucleotide catabolic processGO:003081310.014
vesicle localizationGO:0051648270.013
g2 m transition of mitotic cell cycleGO:000008640.013
regulation of alternative mrna splicing via spliceosomeGO:000038110.013
melanosome transportGO:0032402190.013
cell cycle g2 m phase transitionGO:004483940.013
post golgi vesicle mediated transportGO:000689210.013
protein targeting to membraneGO:000661210.013
response to endogenous stimulusGO:0009719830.013
protein acylationGO:004354330.013
mitotic dna damage checkpointGO:004477340.013
regulation of gtpase activityGO:004308720.013
photoreceptor cell developmentGO:0042461400.013
regulation of dna replicationGO:000627530.013
neurotransmitter secretionGO:000726920.013
embryonic cranial skeleton morphogenesisGO:0048701900.013
regulation of synaptic growth at neuromuscular junctionGO:000858210.013
muscle structure developmentGO:00610611960.013
phosphorus metabolic processGO:00067931090.013
establishment of organelle localizationGO:0051656450.013
determination of heart left right asymmetryGO:00613711170.013
regulation of blood vessel sizeGO:005088020.013
regulation of inflammatory responseGO:005072720.013
programmed cell deathGO:00125011190.013
cellular protein modification processGO:00064641000.013
positive regulation of nitrogen compound metabolic processGO:0051173690.013
response to other organismGO:0051707970.013
regulation of dendrite developmentGO:005077330.013
peptidyl lysine acetylationGO:001839420.013
response to unfolded proteinGO:000698620.013
production of molecular mediator of immune responseGO:000244020.013
ribonucleoside monophosphate catabolic processGO:000915840.013
cellular amide metabolic processGO:004360340.013
regulation of production of molecular mediator of immune responseGO:000270010.013
positive regulation of nucleoside metabolic processGO:004597910.013
post embryonic organ developmentGO:004856940.013
somatic stem cell maintenanceGO:003501910.013
positive regulation of cellular amino acid metabolic processGO:004576400.013
regulation of ion transmembrane transporter activityGO:003241220.013
response to ketoneGO:190165410.013
positive regulation of gtpase activityGO:004354710.013
negative regulation of response to stimulusGO:00485851040.012
protein polyubiquitinationGO:000020940.012
chemosensory behaviorGO:000763510.012
leukocyte proliferationGO:007066110.012
outflow tract morphogenesisGO:000315110.012
purine ribonucleoside monophosphate catabolic processGO:000916940.012
nuclear exportGO:005116810.012
lateral inhibitionGO:004633110.012
response to external biotic stimulusGO:0043207970.012
negative regulation of protein serine threonine kinase activityGO:007190120.012
growthGO:00400071740.012
retina morphogenesis in camera type eyeGO:0060042790.012
response to oxygen containing compoundGO:1901700550.012
negative regulation of intracellular transportGO:003238730.012
multi organism processGO:00517041340.012
internal peptidyl lysine acetylationGO:001839320.012
stem cell divisionGO:001714510.012
negative regulation of mapk cascadeGO:004340940.012
positive regulation of stress activated mapk cascadeGO:003287430.012
epithelial tube morphogenesisGO:00605621480.012
negative regulation of programmed cell deathGO:0043069580.012
meiotic chromosome segregationGO:004513230.012
regulation of cell projection assemblyGO:006049140.012
angiogenesisGO:00015251580.012
interspecies interaction between organismsGO:004441940.012
tissue remodelingGO:004877140.012
establishment of protein localization to plasma membraneGO:009000210.012
macromolecular complex disassemblyGO:003298410.012
regulation of response to biotic stimulusGO:000283120.012
cilium assemblyGO:0042384580.012
negative regulation of nucleocytoplasmic transportGO:004682320.012
pancreas developmentGO:0031016840.012
response to biotic stimulusGO:0009607970.012
negative regulation of apoptotic processGO:0043066550.012
heart contractionGO:0060047710.012
locomotor rhythmGO:004547530.012
negative regulation of defense responseGO:003134820.012
protein complex disassemblyGO:004324110.012
sensory perception of painGO:001923310.012
cellular response to stressGO:0033554620.012
atp catabolic processGO:000620040.012
transmembrane transportGO:00550851200.012
adherens junction organizationGO:003433240.012
activation of mapk activityGO:000018730.011
mesenchyme developmentGO:00604851270.011
nucleoside monophosphate catabolic processGO:000912540.011
axonogenesisGO:00074091520.011
lipid catabolic processGO:001604240.011
positive regulation of gtp catabolic processGO:003312610.011
blood circulationGO:0008015870.011
symbiosis encompassing mutualism through parasitismGO:004440340.011
embryonic skeletal system developmentGO:0048706970.011
axon developmentGO:00615641660.011
regulation of nervous system developmentGO:0051960900.011
establishment of pigment granule localizationGO:0051905220.011
renal system developmentGO:0072001940.011
kidney developmentGO:0001822920.011
negative regulation of cytoplasmic transportGO:190365020.011
positive regulation of dna metabolic processGO:005105410.011
cellular respirationGO:004533330.011
multi organism cellular processGO:004476420.011
negative regulation of map kinase activityGO:004340720.011
cell morphogenesis involved in neuron differentiationGO:00486671630.011
positive regulation of cellular amine metabolic processGO:003324000.011
neuron projection developmentGO:00311751800.011
alcohol biosynthetic processGO:004616520.011
cytoskeleton dependent cytokinesisGO:006164030.011
response to organic cyclic compoundGO:0014070510.011
negative regulation of intracellular protein transportGO:009031730.011
er nucleus signaling pathwayGO:000698420.011
action potentialGO:0001508190.011
peptide metabolic processGO:000651810.011
cell projection assemblyGO:0030031640.011
response to corticosteroidGO:003196010.011
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.011
sequestering of metal ionGO:005123830.011
lymphocyte proliferationGO:004665110.011
positive regulation of multi organism processGO:004390230.011
negative regulation of biosynthetic processGO:0009890550.011
negative regulation of cellular catabolic processGO:003133030.011
response to glucocorticoidGO:005138410.011
purine nucleoside monophosphate catabolic processGO:000912840.011
actin filament based movementGO:003004810.010
viral processGO:001603210.010
embryonic skeletal system morphogenesisGO:0048704930.010
pectoral fin developmentGO:0033339500.010
negative regulation of cellular metabolic processGO:0031324770.010
dorsal ventral pattern formationGO:00099531250.010
regulation of peptidyl tyrosine phosphorylationGO:005073010.010
positive regulation of protein polymerizationGO:003227320.010
organism emergence from protective structureGO:007168440.010
appendage developmentGO:0048736800.010
regulation of blood pressureGO:000821710.010
negative regulation of cytokine productionGO:000181810.010
negative regulation of cell communicationGO:0010648960.010
regulation of phGO:000688530.010
melanin metabolic processGO:000658220.010

cul4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.041
nervous system diseaseDOID:86300.020
disease of cellular proliferationDOID:1456600.017
cancerDOID:16200.015
organ system cancerDOID:005068600.015
disease of metabolismDOID:001466700.015
musculoskeletal system diseaseDOID:1700.014
cardiovascular system diseaseDOID:128700.011
inherited metabolic disorderDOID:65500.010