Danio rerio

110 known processes

mxtx1

mix-type homeobox gene 1

(Aliases: sb:cb779,MGC152852,mtx1)

mxtx1 biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
aromatic compound biosynthetic processGO:00194382170.501
cellular aromatic compound metabolic processGO:00067252950.476
transcription dna templatedGO:00063511810.420
regulation of rna biosynthetic processGO:20011412130.347
organic cyclic compound biosynthetic processGO:19013622230.346
organic substance biosynthetic processGO:19015762890.342
nucleobase containing compound biosynthetic processGO:00346542050.324
regulation of cellular biosynthetic processGO:00313262450.301
regulation of biosynthetic processGO:00098892500.301
cellular macromolecule biosynthetic processGO:00346452240.300
nitrogen compound metabolic processGO:00068073190.300
regulation of nucleic acid templated transcriptionGO:19035062130.288
sensory organ developmentGO:00074233930.285
Zebrafish
cell motilityGO:00488702440.278
nucleic acid metabolic processGO:00903042440.272
macromolecule biosynthetic processGO:00090592270.261
regulation of nitrogen compound metabolic processGO:00511712510.260
rna biosynthetic processGO:00327741810.258
regulation of rna metabolic processGO:00512522240.238
larval developmentGO:000216420.222
regulation of macromolecule biosynthetic processGO:00105562250.216
cellular nitrogen compound biosynthetic processGO:00442712180.200
regulation of transcription dna templatedGO:00063552130.199
gene expressionGO:00104672520.181
rna metabolic processGO:00160702190.179
negative regulation of biological processGO:00485193040.179
Human
cellular macromolecule metabolic processGO:00442603910.178
neuron differentiationGO:00301823530.172
Zebrafish
regulation of cellular metabolic processGO:00313233200.162
biosynthetic processGO:00090582940.156
nucleic acid templated transcriptionGO:00976591810.151
cellular biosynthetic processGO:00442492860.150
heterocycle metabolic processGO:00464832900.142
regulation of macromolecule metabolic processGO:00602553170.132
transcription from rna polymerase ii promoterGO:0006366800.126
Human Mouse
regulation of cellular macromolecule biosynthetic processGO:20001122220.118
immune system processGO:00023762410.117
organic cyclic compound metabolic processGO:19013603010.111
response to chemicalGO:00422213200.106
generation of neuronsGO:00486993850.105
Zebrafish
endoderm developmentGO:0007492490.101
Zebrafish
cellular nitrogen compound metabolic processGO:00346412900.100
segmentationGO:0035282970.095
embryo development ending in birth or egg hatchingGO:00097922710.094
nucleobase containing compound metabolic processGO:00061392740.092
locomotionGO:00400113130.091
tube morphogenesisGO:00352393490.090
negative regulation of macromolecule metabolic processGO:0010605760.089
Human
ameboidal type cell migrationGO:00016671430.086
Zebrafish
response to stressGO:00069502630.085
heterocycle biosynthetic processGO:00181302150.085
cell part morphogenesisGO:00329902460.084
cell morphogenesis involved in neuron differentiationGO:00486671630.082
negative regulation of cellular processGO:00485232830.082
Human
localization of cellGO:00516742440.081
cell migrationGO:00164772370.081
regulation of gene expressionGO:00104682650.080
neuron developmentGO:00486662620.077
cellular component movementGO:00069283350.075
sensory perception of chemical stimulusGO:000760630.074
regulation of metabolic processGO:00192223590.074
regulation of transcription from rna polymerase ii promoterGO:00063571140.071
Human Mouse
somitogenesisGO:0001756870.067
regulation of nucleobase containing compound metabolic processGO:00192192500.065
vasculature developmentGO:00019442780.063
Mouse
cell surface receptor signaling pathwayGO:00071663250.061
regulation of protein complex assemblyGO:004325430.060
eye developmentGO:00016542770.060
Zebrafish
single organism biosynthetic processGO:0044711710.060
agingGO:000756820.059
positive regulation of gene expressionGO:0010628710.059
homeostatic processGO:00425921420.058
head developmentGO:00603223030.058
Zebrafish
regulation of primary metabolic processGO:00800903110.058
gland developmentGO:00487321430.057
Zebrafish
positive regulation of cellular component biogenesisGO:004408930.057
digestive tract morphogenesisGO:00485462310.056
system processGO:00030081850.056
positive regulation of cellular catabolic processGO:003133130.055
chordate embryonic developmentGO:00430092710.054
signal transductionGO:00071654550.054
establishment of localizationGO:00512342440.053
gastrulationGO:00073692080.053
anterior posterior pattern specificationGO:00099521520.053
compound eye developmentGO:004874920.052
cell projection organizationGO:00300302840.052
positive regulation of cellular processGO:00485222010.052
digestive system developmentGO:00551232890.051
convergent extensionGO:00600261180.051
blood vessel developmentGO:00015682460.050
Mouse
central nervous system developmentGO:00074173870.050
Zebrafish
regulation of cell motilityGO:2000145460.049
stem cell proliferationGO:007208940.049
positive regulation of transportGO:005105020.048
multicellular organism growthGO:003526440.048
cell fate specificationGO:0001708680.048
Zebrafish
photoreceptor cell differentiationGO:0046530550.047
Zebrafish
negative regulation of cell communicationGO:0010648960.047
positive regulation of nucleic acid templated transcriptionGO:1903508570.046
guanosine containing compound metabolic processGO:190106840.046
hemopoiesisGO:00300971830.046
negative regulation of protein complex assemblyGO:003133310.046
negative regulation of nitrogen compound metabolic processGO:0051172590.046
Human
retina development in camera type eyeGO:00600411460.046
Zebrafish
chemotaxisGO:00069351040.044
cardiac cell fate commitmentGO:006091110.043
taxisGO:00423301090.043
negative regulation of metabolic processGO:0009892860.042
Human
ubiquitin dependent protein catabolic processGO:000651130.042
maintenance of locationGO:005123540.041
protein localization to nucleusGO:003450430.041
sensory organ morphogenesisGO:00905962000.041
Zebrafish
muscle structure developmentGO:00610611960.040
somite developmentGO:0061053960.039
digestive tract developmentGO:00485652650.039
positive regulation of cell adhesionGO:004578510.039
transportGO:00068102200.038
fatty acid biosynthetic processGO:000663340.038
camera type eye developmentGO:00430102220.038
Zebrafish
organelle organizationGO:00069962270.038
negative regulation of protein phosphorylationGO:000193340.037
negative regulation of biosynthetic processGO:0009890550.037
Human
regulation of signalingGO:00230512350.037
tissue remodelingGO:004877140.037
phagocytosisGO:000690930.037
regulation of signal transductionGO:00099662250.037
anatomical structure homeostasisGO:0060249360.036
cell migration involved in gastrulationGO:0042074790.036
cellular component morphogenesisGO:00329893360.036
hematopoietic or lymphoid organ developmentGO:00485341910.036
negative regulation of mesodermal cell fate specificationGO:004266230.035
neuron projection morphogenesisGO:00488121610.035
eye morphogenesisGO:00485921440.034
Zebrafish
developmental growth involved in morphogenesisGO:0060560860.034
regionalizationGO:00030022740.034
regulation of protein transportGO:005122330.034
neural retina developmentGO:0003407490.033
Zebrafish
regulation of multicellular organismal developmentGO:20000262230.033
negative regulation of transcription dna templatedGO:0045892450.033
Human
lipid storageGO:001991510.032
chemosensory behaviorGO:000763510.032
mesoderm developmentGO:0007498880.032
stem cell divisionGO:001714510.031
response to carbohydrateGO:000974330.031
negative regulation of rna biosynthetic processGO:1902679450.030
Human
neuron projection developmentGO:00311751800.030
positive regulation of catabolic processGO:000989640.030
stem cell developmentGO:0048864820.029
Zebrafish
multi organism processGO:00517041340.029
response to external stimulusGO:00096052640.029
regulation of response to stimulusGO:00485832690.029
regulation of mrna splicing via spliceosomeGO:004802430.029
response to glucoseGO:000974930.029
negative regulation of gene expressionGO:0010629650.029
Human
regulation of localizationGO:00328791040.029
morphogenesis of an epitheliumGO:00020093330.029
positive regulation of response to stimulusGO:0048584800.029
negative regulation of signal transductionGO:0009968940.029
negative regulation of nucleic acid templated transcriptionGO:1903507450.028
Human
positive regulation of nitrogen compound metabolic processGO:0051173690.028
mesoderm morphogenesisGO:0048332510.028
axon developmentGO:00615641660.027
blood vessel morphogenesisGO:00485142160.027
erythrocyte differentiationGO:0030218540.027
axonogenesisGO:00074091520.027
stem cell maintenanceGO:001982740.026
convergent extension involved in gastrulationGO:0060027710.026
regulation of bindingGO:005109830.026
regulation of cell differentiationGO:00455951420.026
regulation of establishment of protein localizationGO:007020140.026
cell substrate adhesionGO:003158940.026
phosphate containing compound metabolic processGO:00067961080.026
neuron projection guidanceGO:0097485860.025
protein polymerizationGO:005125840.025
embryonic pattern specificationGO:0009880440.025
regulation of cellular component organizationGO:0051128860.025
cell projection morphogenesisGO:00488582440.024
phagocytosis engulfmentGO:000691110.024
positive regulation of notch signaling pathwayGO:004574730.024
regulation of locomotionGO:0040012550.024
cellular response to chemical stimulusGO:00708871570.024
regulation of cellular component movementGO:0051270550.024
regulation of cellular amine metabolic processGO:003323800.024
axon guidanceGO:0007411860.024
bmp signaling pathwayGO:0030509520.023
fatty acid transportGO:001590810.023
regulation of developmental processGO:00507932470.023
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.023
immune system developmentGO:00025201910.023
notochord developmentGO:0030903540.023
regulation of stem cell proliferationGO:007209120.023
brain developmentGO:00074202930.022
Zebrafish
negative regulation of multicellular organismal processGO:0051241690.022
regulation of reproductive processGO:200024140.022
negative regulation of protein kinase activityGO:000646940.022
regulation of synaptic plasticityGO:004816710.022
hatching gland developmentGO:004878530.022
cellular amine metabolic processGO:004410620.022
intracellular signal transductionGO:0035556850.022
cell fate commitmentGO:0045165990.022
Zebrafish
dorsal ventral pattern formationGO:00099531250.022
organic acid metabolic processGO:0006082310.022
regulation of cell communicationGO:00106462320.022
regulation of stem cell differentiationGO:200073640.021
regulation of molecular functionGO:0065009700.021
modification dependent protein catabolic processGO:001994130.021
proteolysis involved in cellular protein catabolic processGO:005160330.021
regulation of multicellular organism growthGO:004001440.021
transmembrane transportGO:00550851200.021
neuron neuron synaptic transmissionGO:000727010.021
positive regulation of muscle organ developmentGO:004863610.021
positive regulation of biological processGO:00485182530.021
alpha amino acid metabolic processGO:190160530.021
growthGO:00400071740.021
response to xenobiotic stimulusGO:0009410450.021
membrane invaginationGO:001032410.021
negative regulation of protein localization to nucleusGO:190018120.020
neuromuscular synaptic transmissionGO:000727420.020
circulatory system processGO:0003013870.020
amine metabolic processGO:000930820.020
regulation of mesoderm developmentGO:2000380110.020
androgen metabolic processGO:000820920.020
epithelial cell differentiationGO:00308551160.020
response to organic substanceGO:00100331530.020
developmental growthGO:00485891660.020
embryonic digestive tract morphogenesisGO:004855730.020
peptidyl threonine phosphorylationGO:001810710.020
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.019
Human
regulation of intracellular protein transportGO:003315730.019
behaviorGO:0007610740.019
gtp catabolic processGO:000618420.019
regulation of transmembrane receptor protein serine threonine kinase signaling pathwayGO:0090092500.019
hormone mediated signaling pathwayGO:000975590.019
muscle organ developmentGO:00075171010.019
regulation of multicellular organismal processGO:00512392770.019
negative regulation of nuclear divisionGO:005178430.019
protein import into nucleusGO:000660630.019
endocrine system developmentGO:0035270650.019
Zebrafish
angiogenesisGO:00015251580.019
adult behaviorGO:003053420.018
specification of organ identityGO:001009220.018
regulation of gtp catabolic processGO:003312420.018
regulation of biological qualityGO:00650082630.018
embryonic organ morphogenesisGO:00485622740.018
Zebrafish
negative regulation of mitosisGO:004583930.018
cell morphogenesisGO:00009022890.018
regulation of inflammatory responseGO:005072720.018
positive regulation of cell cycleGO:004578730.018
response to endogenous stimulusGO:0009719830.017
neural tube patterningGO:0021532330.017
gene silencing by rnaGO:003104740.017
negative regulation of signalingGO:0023057960.017
negative regulation of cellular metabolic processGO:0031324770.017
Human
somite specificationGO:0001757120.017
regulation of purine nucleotide catabolic processGO:003312120.017
apoptotic processGO:00069151160.017
regulation of cytokine productionGO:000181730.017
sleepGO:003043110.017
estrogen metabolic processGO:000821020.017
bone remodelingGO:004684920.017
positive regulation of signal transductionGO:0009967560.017
actin polymerization or depolymerizationGO:000815420.017
ear developmentGO:00435831270.017
positive regulation of canonical wnt signaling pathwayGO:009026340.017
positive regulation of cellular biosynthetic processGO:0031328680.017
negative regulation of response to stimulusGO:00485851040.017
peptidyl serine modificationGO:001820920.017
response to hexoseGO:000974630.016
regulation of cell shapeGO:000836010.016
segment specificationGO:0007379120.016
peptidyl threonine modificationGO:001821010.016
eye photoreceptor cell differentiationGO:0001754450.016
Zebrafish
camera type eye morphogenesisGO:00485931080.016
Zebrafish
wnt signaling pathwayGO:0016055800.016
outflow tract morphogenesisGO:000315110.016
morphogenesis of an epithelial sheetGO:0002011490.016
mitochondrion organizationGO:000700540.016
positive regulation of gtp catabolic processGO:003312610.016
positive regulation of macromolecule biosynthetic processGO:0010557590.016
regulation of protein ubiquitinationGO:003139630.016
single organism transportGO:00447652060.016
negative regulation of rna metabolic processGO:0051253480.016
Human
protein localizationGO:0008104400.016
positive regulation of secretionGO:005104710.016
cellular response to endogenous stimulusGO:0071495680.016
cellular response to extracellular stimulusGO:003166820.016
cell proliferationGO:0008283800.016
endodermal cell differentiationGO:0035987190.016
guanosine containing compound catabolic processGO:190106920.016
carboxylic acid metabolic processGO:0019752220.016
appendage developmentGO:0048736800.016
cellular carbohydrate metabolic processGO:004426240.016
regulation of organ morphogenesisGO:2000027350.016
carboxylic acid catabolic processGO:004639530.016
nuclear importGO:005117030.016
heart developmentGO:00075073130.016
developmental cell growthGO:0048588520.016
oocyte anterior posterior axis specificationGO:000731440.015
protein phosphorylationGO:0006468470.015
proteasome mediated ubiquitin dependent protein catabolic processGO:004316120.015
heart processGO:0003015710.015
reproductive processGO:0022414400.015
Mouse
urogenital system developmentGO:0001655970.015
single organism metabolic processGO:00447102170.015
cellular amino acid metabolic processGO:000652070.015
positive regulation of nucleotide catabolic processGO:003081310.015
cellular response to stressGO:0033554620.015
muscle cell differentiationGO:00426921390.015
peptidyl serine phosphorylationGO:001810510.015
regulation of cellular ketone metabolic processGO:001056570.015
phosphorus metabolic processGO:00067931090.015
lipid homeostasisGO:005508830.015
hepatocyte differentiationGO:007036510.015
cell morphogenesis involved in differentiationGO:00009041950.015
epidermal cell fate specificationGO:000995740.015
long chain fatty acid transportGO:001590910.015
regulation of nucleoside metabolic processGO:000911820.015
organic substance transportGO:0071702580.015
modification dependent macromolecule catabolic processGO:004363230.015
regulation of protein polymerizationGO:003227120.015
androgen biosynthetic processGO:000670210.015
regulation of cellular amino acid metabolic processGO:000652100.015
liver developmentGO:0001889960.014
negative regulation of nucleobase containing compound metabolic processGO:0045934590.014
Human
positive regulation of cellular metabolic processGO:0031325940.014
regulation of response to external stimulusGO:0032101310.014
positive regulation of signalingGO:0023056560.014
synaptic growth at neuromuscular junctionGO:005112420.014
cell matrix adhesionGO:000716040.014
nuclear transportGO:005116940.014
skeletal muscle organ developmentGO:0060538780.014
protein targeting to nucleusGO:004474430.014
intestinal absorptionGO:005089220.014
somatic muscle developmentGO:000752540.014
negative regulation of macromolecule biosynthetic processGO:0010558480.014
Human
multi organism reproductive processGO:0044703360.014
regulation of protein modification by small protein conjugation or removalGO:190332030.014
sensory system developmentGO:0048880760.014
regulation of wnt signaling pathway involved in heart developmentGO:000330720.013
regulation of neural precursor cell proliferationGO:200017730.013
epithelial tube morphogenesisGO:00605621480.013
extracellular matrix assemblyGO:008502910.013
regulation of circadian rhythmGO:004275240.013
myeloid cell differentiationGO:0030099860.013
regulation of cell projection assemblyGO:006049140.013
positive regulation of cellular amine metabolic processGO:003324000.013
regulation of gtpase activityGO:004308720.013
single organism nuclear importGO:190259330.013
cell adhesion mediated by integrinGO:003362710.013
cellular response to organic substanceGO:00713101050.013
ion transportGO:00068111140.013
negative regulation of kinase activityGO:003367340.013
regulation of circadian sleep wake cycleGO:004274910.013
positive regulation of muscle tissue developmentGO:190186310.013
positive regulation of protein polymerizationGO:003227320.013
protein homooligomerizationGO:005126030.013
appendage morphogenesisGO:0035107560.013
neural tube developmentGO:0021915620.013
connective tissue developmentGO:0061448990.013
catecholamine metabolic processGO:000658420.013
embryonic heart tube developmentGO:00350501330.013
protein polyubiquitinationGO:000020940.013
regulation of meiotic cell cycleGO:005144510.013
embryonic hemopoiesisGO:0035162530.013
cellular response to external stimulusGO:007149620.013
hormone secretionGO:004687920.013
response to external biotic stimulusGO:0043207970.013
response to alkaloidGO:004327920.013
protein complex disassemblyGO:004324110.013
regulation of protein localization to nucleusGO:190018020.013
response to monosaccharideGO:003428430.013
cognitionGO:005089010.013
meiotic nuclear divisionGO:000712640.013
regulation of calcium ion transportGO:005192420.013
morphogenesis of an epithelial foldGO:006057110.013
canonical wnt signaling pathwayGO:0060070480.013
mesoderm formationGO:0001707430.013
embryonic digestive tract developmentGO:004856640.013
cellular component biogenesisGO:00440851780.013
carbohydrate biosynthetic processGO:001605110.013
neurotransmitter transportGO:000683620.012
positive regulation of cell communicationGO:0010647560.012
embryonic organ developmentGO:00485683810.012
protein heterooligomerizationGO:005129110.012
skeletal system developmentGO:00015011810.012
regulation of nucleotide catabolic processGO:003081120.012
rhombomere 6 developmentGO:002157240.012
hormone transportGO:000991420.012
positive regulation of nucleobase containing compound metabolic processGO:0045935690.012
cellular response to molecule of bacterial originGO:007121930.012
gtp metabolic processGO:004603940.012
wound healingGO:0042060900.012
protein importGO:001703830.012
anion homeostasisGO:005508190.012
negative regulation of intracellular transportGO:003238730.012
formation of primary germ layerGO:0001704620.012
macromolecular complex disassemblyGO:003298410.012
deathGO:00162651210.012
regulation of neurogenesisGO:0050767870.012
oxoacid metabolic processGO:0043436310.012
aorta morphogenesisGO:003590930.012
regulation of synaptic growth at neuromuscular junctionGO:000858210.012
negative regulation of dna metabolic processGO:005105340.012
phosphorylationGO:0016310690.012
eye photoreceptor cell developmentGO:0042462300.012
positive regulation of transcription dna templatedGO:0045893570.012
autophagyGO:000691440.012
negative regulation of cellular biosynthetic processGO:0031327550.012
Human
somite rostral caudal axis specificationGO:003252550.012
regulation of cell substrate adhesionGO:001081010.012
cellular protein catabolic processGO:004425740.012
protein stabilizationGO:005082120.012
enzyme linked receptor protein signaling pathwayGO:00071671060.011
positive regulation of secretion by cellGO:190353210.011
positive regulation of cytokine productionGO:000181920.011
circadian sleep wake cycleGO:004274520.011
cellular component disassemblyGO:002241110.011
positive regulation of neural precursor cell proliferationGO:200017910.011
positive regulation of gtpase activityGO:004354710.011
oocyte maturationGO:000155640.011
heart contractionGO:0060047710.011
nuclear transcribed mrna catabolic process nonsense mediated decayGO:000018440.011
retina morphogenesis in camera type eyeGO:0060042790.011
Zebrafish
negative regulation of cytokine productionGO:000181810.011
endothelial cell fate commitmentGO:006083930.011
tissue homeostasisGO:0001894250.011
regulation of ion transmembrane transporter activityGO:003241220.011
positive regulation of transcription from rna polymerase ii promoterGO:0045944220.011
regulation of cell migrationGO:0030334400.011
establishment of protein localization to organelleGO:007259440.011
organonitrogen compound metabolic processGO:1901564740.011
negative regulation of cellular catabolic processGO:003133030.011
anterior posterior axis specificationGO:0009948200.011
retinal rod cell developmentGO:004654840.011
positive regulation of rna biosynthetic processGO:1902680570.011
smooth muscle contractionGO:000693920.011
stem cell differentiationGO:00488631170.011
Zebrafish
cell cycleGO:0007049930.011
Human
positive regulation of muscle cell differentiationGO:005114910.011
production of molecular mediator of immune responseGO:000244020.011
positive regulation of cell killingGO:003134320.011
cellular response to growth factor stimulusGO:0071363390.011
dopamine metabolic processGO:004241720.011
regulation of synapse organizationGO:005080730.011
positive regulation of leukocyte differentiationGO:190210710.011
regulation of mesodermal cell fate specificationGO:004266190.010
negative regulation of catalytic activityGO:0043086210.010
single organism localizationGO:19025782250.010
leukocyte chemotaxisGO:0030595120.010
regulation of extrinsic apoptotic signaling pathwayGO:200123630.010
regulation of intracellular signal transductionGO:1902531570.010
dna templated transcription initiationGO:000635210.010
regulation of cell activationGO:005086510.010
cardiac chamber formationGO:000320740.010
camera type eye photoreceptor cell differentiationGO:0060219190.010
Zebrafish
positive regulation of cytoskeleton organizationGO:005149530.010
muscle tissue developmentGO:00605371100.010
cellular ketone metabolic processGO:0042180110.010
cellular response to biotic stimulusGO:007121630.010
regulation of glial cell differentiationGO:004568540.010
striated muscle cell differentiationGO:00511461290.010
single organism organelle organizationGO:19025891990.010
spemann organizer formation at the embryonic shieldGO:006006320.010
regulation of protein complex disassemblyGO:004324410.010
regulation of endothelial cell proliferationGO:000193610.010
small molecule catabolic processGO:004428230.010
diencephalon developmentGO:0021536580.010
Zebrafish
protein secretionGO:000930610.010

mxtx1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.031
musculoskeletal system diseaseDOID:1700.031
disease of cellular proliferationDOID:1456600.024
cancerDOID:16200.024
bone diseaseDOID:008000100.021
connective tissue diseaseDOID:6500.021
bone development diseaseDOID:008000600.016
organ system cancerDOID:005068600.013
retinal degenerationDOID:846600.012
sensory system diseaseDOID:005015500.012
retinal diseaseDOID:567900.012
eye and adnexa diseaseDOID:149200.012
nervous system diseaseDOID:86300.012
eye diseaseDOID:561400.012
immune system diseaseDOID:291400.010