IMP: Integrative Multi-species Prediction

Danio rerio

0 known processes

lhx1b

LIM homeobox 1b

(Aliases: lim6)

Ensembl: ENSDARG00000007944
Entrez: 30454
ZFIN: ZDB-GENE-980526-116
UniProtKB: O13106

Process Predictions
Disease Predictions

lhx1b biological process predictions

Show only novel predictionsHighlight processes of functional analogs

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Biological process	GO term ID	Process size	Probability	Func Analog Org
nucleic acid templated transcription	GO:0097659	181	0.879	Mouse Fly
regulation of nucleobase containing compound metabolic process	GO:0019219	250	0.877	Mouse Fly
generation of neurons	GO:0048699	385	0.848	Zebrafish Mouse Worm
regulation of macromolecule metabolic process	GO:0060255	317	0.809	Zebrafish Mouse Fly
regionalization	GO:0003002	274	0.801	Zebrafish Mouse Fly
brain development	GO:0007420	293	0.790	Zebrafish Mouse
tube morphogenesis	GO:0035239	349	0.736	Zebrafish Mouse
biosynthetic process	GO:0009058	294	0.723	Mouse Fly
aromatic compound biosynthetic process	GO:0019438	217	0.707	Mouse Fly
cellular macromolecule metabolic process	GO:0044260	391	0.642	Mouse Fly
regulation of gene expression	GO:0010468	265	0.626	Zebrafish Mouse Fly
chordate embryonic development	GO:0043009	271	0.621	Zebrafish Mouse
embryonic camera type eye formation	GO:0060900	10	0.607	Zebrafish
cellular aromatic compound metabolic process	GO:0006725	295	0.599	Mouse Fly
axon guidance	GO:0007411	86	0.597	Zebrafish Mouse
cell morphogenesis involved in neuron differentiation	GO:0048667	163	0.592	Zebrafish Mouse
nitrogen compound metabolic process	GO:0006807	319	0.585	Mouse Fly
regulation of primary metabolic process	GO:0080090	311	0.573	Mouse Fly
cellular component movement	GO:0006928	335	0.563	Zebrafish Mouse Worm
morphogenesis of an epithelium	GO:0002009	333	0.554	Zebrafish Mouse
negative regulation of cellular process	GO:0048523	283	0.549	Mouse Fly
regulation of rna metabolic process	GO:0051252	224	0.549	Mouse Fly
response to external stimulus	GO:0009605	264	0.544	Zebrafish Mouse
regulation of endodermal cell fate specification	GO:0042663	15	0.540
striated muscle cell differentiation	GO:0051146	129	0.530	Zebrafish
head development	GO:0060322	303	0.526	Zebrafish Mouse
dorsal ventral pattern formation	GO:0009953	125	0.519	Mouse
organic cyclic compound metabolic process	GO:1901360	301	0.516	Mouse Fly
central nervous system development	GO:0007417	387	0.511	Zebrafish Mouse
regulation of transcription dna templated	GO:0006355	213	0.501	Mouse Fly
regulation of cellular macromolecule biosynthetic process	GO:2000112	222	0.496	Mouse Fly
embryonic organ development	GO:0048568	381	0.489	Zebrafish Mouse
rna metabolic process	GO:0016070	219	0.483	Mouse Fly
sensory organ development	GO:0007423	393	0.477	Zebrafish Mouse Fly
specification of symmetry	GO:0009799	204	0.474
cellular macromolecule biosynthetic process	GO:0034645	224	0.471	Mouse Fly
regulation of nucleic acid templated transcription	GO:1903506	213	0.469	Mouse Fly
cell fate commitment	GO:0045165	99	0.469	Zebrafish Worm
neuron projection morphogenesis	GO:0048812	161	0.463	Zebrafish Mouse
neuron differentiation	GO:0030182	353	0.461	Zebrafish Mouse Worm
heterocycle biosynthetic process	GO:0018130	215	0.459	Mouse Fly
blood vessel development	GO:0001568	246	0.456
organic substance biosynthetic process	GO:1901576	289	0.449	Mouse Fly
cellular nitrogen compound biosynthetic process	GO:0044271	218	0.446	Mouse Fly
regulation of metabolic process	GO:0019222	359	0.443	Zebrafish Mouse Fly
regulation of reproductive process	GO:2000241	4	0.436
cellular nitrogen compound metabolic process	GO:0034641	290	0.435	Mouse Fly
somitogenesis	GO:0001756	87	0.429	Mouse
camera type eye development	GO:0043010	222	0.428	Zebrafish Mouse
gastrulation	GO:0007369	208	0.424	Mouse
transcription from rna polymerase ii promoter	GO:0006366	80	0.422	Mouse
convergent extension	GO:0060026	118	0.421
transcription dna templated	GO:0006351	181	0.421	Mouse Fly
regulation of nitrogen compound metabolic process	GO:0051171	251	0.421	Mouse Fly
nucleobase containing compound metabolic process	GO:0006139	274	0.416	Mouse Fly
nucleobase containing compound biosynthetic process	GO:0034654	205	0.408	Mouse Fly
regulation of macromolecule biosynthetic process	GO:0010556	225	0.406	Mouse Fly
skeletal system development	GO:0001501	181	0.400	Mouse
regulation of rna biosynthetic process	GO:2001141	213	0.389	Mouse Fly
vasculature development	GO:0001944	278	0.386
regulation of cellular metabolic process	GO:0031323	320	0.372	Mouse Fly
muscle structure development	GO:0061061	196	0.365	Zebrafish
blood vessel morphogenesis	GO:0048514	216	0.360
embryo development ending in birth or egg hatching	GO:0009792	271	0.357	Zebrafish Mouse
digestive system development	GO:0055123	289	0.350	Zebrafish Mouse
heterocycle metabolic process	GO:0046483	290	0.347	Mouse Fly
central nervous system neuron differentiation	GO:0021953	74	0.346	Zebrafish Mouse
digestive tract morphogenesis	GO:0048546	231	0.337	Mouse
embryonic heart tube development	GO:0035050	133	0.334
determination of left right symmetry	GO:0007368	179	0.318
embryonic camera type eye morphogenesis	GO:0048596	19	0.316	Zebrafish
hindbrain development	GO:0030902	91	0.315	Zebrafish Mouse
heart looping	GO:0001947	94	0.311
determination of heart left right asymmetry	GO:0061371	117	0.293
organic cyclic compound biosynthetic process	GO:1901362	223	0.286	Mouse Fly
formation of primary germ layer	GO:0001704	62	0.284	Mouse
camera type eye morphogenesis	GO:0048593	108	0.279	Zebrafish Mouse
rna biosynthetic process	GO:0032774	181	0.275	Mouse Fly
embryonic organ morphogenesis	GO:0048562	274	0.267	Zebrafish Mouse
stem cell maintenance	GO:0019827	4	0.265
regulation of multicellular organismal process	GO:0051239	277	0.263	Zebrafish Mouse Worm
regulation of multicellular organismal development	GO:2000026	223	0.259	Mouse Worm
axon development	GO:0061564	166	0.256	Zebrafish Mouse Worm
muscle organ development	GO:0007517	101	0.252
ventral spinal cord development	GO:0021517	35	0.252	Zebrafish Mouse
neuron projection guidance	GO:0097485	86	0.250	Zebrafish Mouse
hindbrain morphogenesis	GO:0021575	22	0.248	Mouse
negative regulation of gene expression	GO:0010629	65	0.247	Mouse Fly
stem cell proliferation	GO:0072089	4	0.247
regulation of developmental process	GO:0050793	247	0.247	Mouse Worm
eye development	GO:0001654	277	0.245	Zebrafish Mouse Fly
positive regulation of macromolecule biosynthetic process	GO:0010557	59	0.242	Mouse Fly
cell fate specification	GO:0001708	68	0.242	Zebrafish Worm
positive regulation of biological process	GO:0048518	253	0.240	Mouse Worm Fly
heart jogging	GO:0003146	40	0.238
macromolecule biosynthetic process	GO:0009059	227	0.238	Mouse Fly
response to other organism	GO:0051707	97	0.237
nucleic acid metabolic process	GO:0090304	244	0.237	Mouse Fly
regulation of transcription from rna polymerase ii promoter	GO:0006357	114	0.236
embryonic heart tube morphogenesis	GO:0003143	108	0.236
cell morphogenesis involved in differentiation	GO:0000904	195	0.235	Zebrafish Mouse
embryonic camera type eye development	GO:0031076	29	0.235	Zebrafish
determination of bilateral symmetry	GO:0009855	204	0.234
regulation of cellular biosynthetic process	GO:0031326	245	0.232	Mouse Fly
cell migration	GO:0016477	237	0.232	Mouse Worm
cardiogenic plate morphogenesis	GO:0003142	1	0.231
epidermis development	GO:0008544	48	0.231	Zebrafish
regulation of biosynthetic process	GO:0009889	250	0.229	Mouse Fly
neuron recognition	GO:0008038	18	0.227	Worm
cellular biosynthetic process	GO:0044249	286	0.226	Mouse Fly
heart morphogenesis	GO:0003007	156	0.225
chondrocyte intercalation involved in growth plate cartilage morphogenesis	GO:0003428	1	0.224
embryonic cranial skeleton morphogenesis	GO:0048701	90	0.223	Mouse
cellular component morphogenesis	GO:0032989	336	0.217	Zebrafish Mouse
somite specification	GO:0001757	12	0.214
embryonic pattern specification	GO:0009880	44	0.200	Mouse
mesoderm morphogenesis	GO:0048332	51	0.198
positive regulation of nucleobase containing compound metabolic process	GO:0045935	69	0.193	Mouse Fly
segmentation	GO:0035282	97	0.192	Mouse
mesodermal cell differentiation	GO:0048333	21	0.192
sensory organ morphogenesis	GO:0090596	200	0.189	Zebrafish Mouse
retina layer formation	GO:0010842	24	0.186	Mouse
epidermal cell fate specification	GO:0009957	4	0.185
mesoderm formation	GO:0001707	43	0.183
endocardium morphogenesis	GO:0003160	4	0.180
oocyte maturation	GO:0001556	4	0.180
larval development	GO:0002164	2	0.177	Worm
localization of cell	GO:0051674	244	0.177	Mouse Worm
neuron development	GO:0048666	262	0.173	Zebrafish Mouse Worm
positive regulation of cellular process	GO:0048522	201	0.173	Mouse Fly
regulation of anatomical structure morphogenesis	GO:0022603	130	0.172	Mouse
regulation of embryonic development	GO:0045995	47	0.171	Mouse
regulation of stem cell differentiation	GO:2000736	4	0.167
immune system process	GO:0002376	241	0.167
endocrine pancreas development	GO:0031018	27	0.165	Zebrafish
taxis	GO:0042330	109	0.164	Zebrafish Mouse
cell projection organization	GO:0030030	284	0.162	Zebrafish Mouse Worm
response to chemical	GO:0042221	320	0.161	Zebrafish Mouse Rat
oligodendrocyte cell fate specification	GO:0021778	4	0.156
endocrine system development	GO:0035270	65	0.154	Zebrafish
embryonic skeletal system development	GO:0048706	97	0.153	Mouse
angiogenesis	GO:0001525	158	0.152
retina development in camera type eye	GO:0060041	146	0.151	Zebrafish Mouse
muscle cell differentiation	GO:0042692	139	0.148	Zebrafish
negative regulation of cellular macromolecule biosynthetic process	GO:2000113	48	0.147	Mouse Fly
axonogenesis	GO:0007409	152	0.147	Zebrafish Mouse
somite development	GO:0061053	96	0.143	Mouse
protein metabolic process	GO:0019538	183	0.143
neuron fate commitment	GO:0048663	26	0.142	Zebrafish
positive regulation of metabolic process	GO:0009893	108	0.142	Mouse Fly
cell differentiation in spinal cord	GO:0021515	40	0.141	Zebrafish Mouse
mesoderm development	GO:0007498	88	0.135
mesenchyme development	GO:0060485	127	0.134
pancreas development	GO:0031016	84	0.133	Zebrafish
endodermal cell differentiation	GO:0035987	19	0.133
positive regulation of transcription from rna polymerase ii promoter	GO:0045944	22	0.132
eye morphogenesis	GO:0048592	144	0.129	Zebrafish Mouse
muscle tissue development	GO:0060537	110	0.129	Zebrafish
rhombomere formation	GO:0021594	12	0.129
response to external biotic stimulus	GO:0043207	97	0.128
neuron fate determination	GO:0048664	2	0.127
mesodermal cell fate specification	GO:0007501	12	0.126
system process	GO:0003008	185	0.126	Zebrafish
cell motility	GO:0048870	244	0.125	Mouse Worm
regulation of mesoderm development	GO:2000380	11	0.125
optic placode formation involved in camera type eye formation	GO:0046619	3	0.124
rostrocaudal neural tube patterning	GO:0021903	29	0.124	Zebrafish
regulation of gastrulation	GO:0010470	24	0.123	Mouse
positive regulation of nitrogen compound metabolic process	GO:0051173	69	0.123	Mouse Fly
aging	GO:0007568	2	0.123
diencephalon development	GO:0021536	58	0.121	Zebrafish
positive regulation of nucleic acid templated transcription	GO:1903508	57	0.121	Mouse Fly
cell projection morphogenesis	GO:0048858	244	0.120	Zebrafish Mouse
single organism organelle organization	GO:1902589	199	0.119
cell morphogenesis	GO:0000902	289	0.118	Zebrafish Mouse
response to stress	GO:0006950	263	0.117
bmp signaling pathway	GO:0030509	52	0.117
negative regulation of biological process	GO:0048519	304	0.115	Mouse Fly
anterior lateral line nerve development	GO:0048909	4	0.115
negative regulation of cell differentiation	GO:0045596	46	0.114
endocardium formation	GO:0060214	1	0.113
cell part morphogenesis	GO:0032990	246	0.113	Zebrafish Mouse
protein targeting to nucleus	GO:0044744	3	0.113
proepicardium development	GO:0003342	4	0.112
hemopoiesis	GO:0030097	183	0.112
striated muscle tissue development	GO:0014706	110	0.111	Zebrafish
positive regulation of rna biosynthetic process	GO:1902680	57	0.111	Mouse Fly
endoderm development	GO:0007492	49	0.111	Mouse
cell growth	GO:0016049	57	0.110	Zebrafish
cell surface receptor signaling pathway involved in heart development	GO:0061311	20	0.109
skeletal system morphogenesis	GO:0048705	102	0.107	Mouse
regulation of endodermal cell differentiation	GO:1903224	15	0.107
gabaergic neuron differentiation	GO:0097154	2	0.104	Zebrafish
septum transversum development	GO:0003343	4	0.103
growth plate cartilage morphogenesis	GO:0003422	1	0.102
regulation of response to stimulus	GO:0048583	269	0.102
digestive tract development	GO:0048565	265	0.102	Mouse
endoderm formation	GO:0001706	29	0.101	Mouse
sensory system development	GO:0048880	76	0.100
negative regulation of nucleobase containing compound metabolic process	GO:0045934	59	0.099	Mouse Fly
rhombomere development	GO:0021546	19	0.099
auditory receptor cell fate determination	GO:0042668	2	0.098
eye field cell fate commitment involved in camera type eye formation	GO:0060898	3	0.098
gene expression	GO:0010467	252	0.098	Zebrafish Mouse Fly
neuron projection development	GO:0031175	180	0.097	Zebrafish Mouse Worm
cardiocyte differentiation	GO:0035051	44	0.097	Zebrafish
ameboidal type cell migration	GO:0001667	143	0.096
positive regulation of cellular metabolic process	GO:0031325	94	0.095	Mouse Fly
stem cell development	GO:0048864	82	0.095
anterior posterior pattern specification	GO:0009952	152	0.095	Zebrafish Mouse
endocardium development	GO:0003157	9	0.094
cartilage development	GO:0051216	96	0.094
epidermal cell differentiation	GO:0009913	36	0.092	Zebrafish
regulation of signal transduction	GO:0009966	225	0.092
bmp signaling pathway involved in determination of left right symmetry	GO:0003154	14	0.091
response to biotic stimulus	GO:0009607	97	0.090
cardiac chamber formation	GO:0003207	4	0.090
stem cell differentiation	GO:0048863	117	0.090
auditory receptor cell fate commitment	GO:0009912	4	0.089
mesodermal cell fate commitment	GO:0001710	14	0.088
embryonic skeletal system morphogenesis	GO:0048704	93	0.087	Mouse
gland development	GO:0048732	143	0.086
regulation of epithelial to mesenchymal transition	GO:0010717	3	0.086
development of primary female sexual characteristics	GO:0046545	4	0.085
glial cell migration	GO:0008347	3	0.085
spinal cord oligodendrocyte cell fate specification	GO:0021530	2	0.084
central nervous system myelin formation	GO:0032289	1	0.084
bmp signaling pathway involved in heart jogging	GO:0003303	14	0.084
negative regulation of cellular metabolic process	GO:0031324	77	0.083	Mouse Fly
neural tube development	GO:0021915	62	0.083	Zebrafish
determination of dorsal ventral asymmetry	GO:0048262	34	0.083
positive regulation of cell cycle	GO:0045787	3	0.083
muscle cell development	GO:0055001	115	0.083
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry	GO:1900094	17	0.082
transmembrane receptor protein serine threonine kinase signaling pathway	GO:0007178	68	0.082
enzyme linked receptor protein signaling pathway	GO:0007167	106	0.080
cellular response to chemical stimulus	GO:0070887	157	0.079	Rat
cell surface receptor signaling pathway	GO:0007166	325	0.079
chemotaxis	GO:0006935	104	0.079	Zebrafish Mouse
regulation of transcription from rna polymerase ii promoter involved in heart development	GO:1901213	15	0.079
neural plate pattern specification	GO:0060896	12	0.079
developmental growth involved in morphogenesis	GO:0060560	86	0.078	Zebrafish Mouse
convergent extension involved in organogenesis	GO:0060029	10	0.077
forebrain regionalization	GO:0021871	4	0.077	Mouse
connective tissue development	GO:0061448	99	0.076
negative regulation of stem cell differentiation	GO:2000737	2	0.075
skeletal muscle organ development	GO:0060538	78	0.075
endodermal cell fate commitment	GO:0001711	18	0.074
cellular protein metabolic process	GO:0044267	129	0.074
developmental cell growth	GO:0048588	52	0.074	Zebrafish
positive regulation of gene expression	GO:0010628	71	0.073	Mouse Fly
oligodendrocyte differentiation	GO:0048709	23	0.073
pharyngeal muscle development	GO:0043282	4	0.072
bmp signaling pathway involved in heart development	GO:0061312	15	0.070
photoreceptor cell fate commitment	GO:0046552	1	0.070
wound healing	GO:0042060	90	0.070
optic placode formation	GO:0001743	4	0.069
forebrain development	GO:0030900	96	0.068	Zebrafish Mouse
multi organism process	GO:0051704	134	0.067	Worm
glial cell fate specification	GO:0021780	4	0.067
floor plate development	GO:0033504	15	0.067
ventral spinal cord interneuron differentiation	GO:0021514	12	0.066
reproduction	GO:0000003	40	0.066	Worm
defense response	GO:0006952	47	0.066
ventral spinal cord interneuron fate commitment	GO:0060579	3	0.066
positive regulation of macromolecule metabolic process	GO:0010604	93	0.066	Mouse Fly
stem cell fate commitment	GO:0048865	1	0.065
polarized epithelial cell differentiation	GO:0030859	4	0.065
positive regulation of cellular biosynthetic process	GO:0031328	68	0.064	Mouse Fly
heart development	GO:0007507	313	0.064	Zebrafish
apoptotic process involved in morphogenesis	GO:0060561	2	0.064
positive regulation of epithelial cell differentiation	GO:0030858	2	0.063	Mouse
developmental growth	GO:0048589	166	0.063	Zebrafish Mouse
otolith development	GO:0048840	32	0.063	Zebrafish
cardiac cell fate commitment	GO:0060911	1	0.063
negative regulation of neuron projection regeneration	GO:0070571	4	0.062
protein import into nucleus	GO:0006606	3	0.062
regulation of bmp signaling pathway	GO:0030510	39	0.061
post anal tail morphogenesis	GO:0036342	19	0.060
regulation of cell communication	GO:0010646	232	0.060
positive regulation of transcription dna templated	GO:0045893	57	0.060	Mouse Fly
regulation of bmp signaling pathway involved in heart jogging	GO:2000223	12	0.060
dna alkylation	GO:0006305	8	0.059
endodermal cell fate specification	GO:0001714	17	0.059
negative regulation of multicellular organismal process	GO:0051241	69	0.058
compound eye development	GO:0048749	2	0.057	Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway	GO:0090092	50	0.057
regulation of stem cell proliferation	GO:0072091	2	0.056
regulation of cell fate specification	GO:0042659	20	0.056
somatic muscle development	GO:0007525	4	0.055
cell migration involved in gastrulation	GO:0042074	79	0.055
regulation of cardiac chamber morphogenesis	GO:1901219	2	0.055
bone morphogenesis	GO:0060349	11	0.055
growth	GO:0040007	174	0.055	Zebrafish Mouse
olfactory lobe development	GO:0021988	4	0.055
non canonical wnt signaling pathway	GO:0035567	13	0.054
regulation of signaling	GO:0023051	235	0.054
negative regulation of transcription dna templated	GO:0045892	45	0.054	Mouse Fly
ear morphogenesis	GO:0042471	64	0.054	Zebrafish
nucleocytoplasmic transport	GO:0006913	4	0.054
oxoacid metabolic process	GO:0043436	31	0.053
neural tube patterning	GO:0021532	33	0.053	Zebrafish
negative regulation of signal transduction	GO:0009968	94	0.053
axial mesodermal cell fate specification	GO:0048327	3	0.053
regulation of inner ear receptor cell differentiation	GO:2000980	1	0.053
cell fate commitment involved in pattern specification	GO:0060581	6	0.052
regulation of cell fate commitment	GO:0010453	22	0.052
thyroid gland development	GO:0030878	12	0.052
negative regulation of developmental process	GO:0051093	65	0.052
regulation of heart morphogenesis	GO:2000826	17	0.052
embryonic retina morphogenesis in camera type eye	GO:0060059	22	0.052	Mouse
forebrain generation of neurons	GO:0021872	14	0.051
signal transduction	GO:0007165	455	0.051
positive regulation of notch signaling pathway	GO:0045747	3	0.051
locomotion	GO:0040011	313	0.051	Zebrafish Mouse Worm
protein modification process	GO:0036211	100	0.051
negative regulation of mesodermal cell fate specification	GO:0042662	3	0.050
mesenchymal cell development	GO:0014031	78	0.050
multicellular organism growth	GO:0035264	4	0.050
cellular component assembly	GO:0022607	170	0.050
negative regulation of nitrogen compound metabolic process	GO:0051172	59	0.050	Mouse Fly
blood circulation	GO:0008015	87	0.050	Zebrafish
embryonic heart tube formation	GO:0003144	1	0.050
wnt signaling pathway involved in digestive tract morphogenesis	GO:0044333	4	0.050
synaptic target recognition	GO:0008039	1	0.049
membrane repolarization	GO:0086009	2	0.049
response to wounding	GO:0009611	116	0.049
epithelial tube morphogenesis	GO:0060562	148	0.049	Mouse
embryonic eye morphogenesis	GO:0048048	30	0.049	Zebrafish
negative regulation of rna metabolic process	GO:0051253	48	0.049	Mouse Fly
apoptotic process involved in development	GO:1902742	2	0.049
type b pancreatic cell development	GO:0003323	4	0.048	Zebrafish
wnt signaling pathway	GO:0016055	80	0.048
positive regulation of map kinase activity	GO:0043406	3	0.048
facial nucleus development	GO:0021754	7	0.048
cardiac muscle cell differentiation	GO:0055007	30	0.047	Zebrafish
response to abiotic stimulus	GO:0009628	122	0.046	Zebrafish
motor neuron axon guidance	GO:0008045	23	0.046	Mouse
regulation of protein transport	GO:0051223	3	0.046
angioblast cell migration involved in selective angioblast sprouting	GO:0035475	4	0.045
hepatic duct development	GO:0061011	2	0.045
axon extension	GO:0048675	45	0.045	Zebrafish
reproductive process	GO:0022414	40	0.045	Mouse Worm
ectodermal placode development	GO:0071696	37	0.045
macromolecule modification	GO:0043412	111	0.045
optic cup morphogenesis involved in camera type eye development	GO:0002072	7	0.045	Zebrafish
cardiac chamber development	GO:0003205	19	0.045
regulation of protein complex assembly	GO:0043254	3	0.044
spinal cord motor neuron differentiation	GO:0021522	26	0.044	Zebrafish
inner ear morphogenesis	GO:0042472	63	0.044	Zebrafish
neural nucleus development	GO:0048857	15	0.043
alpha amino acid metabolic process	GO:1901605	3	0.043
negative regulation of axon regeneration	GO:0048681	4	0.043
negative regulation of reproductive process	GO:2000242	3	0.043
positive regulation of rna metabolic process	GO:0051254	59	0.042	Mouse Fly
lateral line system development	GO:0048925	76	0.042
regulation of growth	GO:0040008	42	0.042
morphogenesis of an epithelial sheet	GO:0002011	49	0.042	Zebrafish
embryonic viscerocranium morphogenesis	GO:0048703	52	0.041	Mouse
cell proliferation in forebrain	GO:0021846	3	0.041
anterior head development	GO:0097065	2	0.041	Mouse
single organism metabolic process	GO:0044710	217	0.041
positive regulation of biosynthetic process	GO:0009891	68	0.041	Mouse Fly
ventral midline development	GO:0007418	13	0.041
regulation of biological quality	GO:0065008	263	0.041
negative regulation of cell fate specification	GO:0009996	11	0.041
cell fate commitment involved in formation of primary germ layer	GO:0060795	26	0.041
hepaticobiliary system development	GO:0061008	98	0.040
protein phosphorylation	GO:0006468	47	0.039
aorta development	GO:0035904	4	0.039
primary neural tube formation	GO:0014020	1	0.039
rhombomere morphogenesis	GO:0021593	17	0.039
rhombomere boundary formation	GO:0021654	10	0.039
appendage morphogenesis	GO:0035107	56	0.039	Fly
growth plate cartilage development	GO:0003417	2	0.039
mesendoderm development	GO:0048382	10	0.039
negative regulation of cell development	GO:0010721	26	0.039
regulation of neurogenesis	GO:0050767	87	0.039
odontogenesis of dentin containing tooth	GO:0042475	1	0.038
erythrocyte development	GO:0048821	24	0.038
response to organic substance	GO:0010033	153	0.038	Rat
dna modification	GO:0006304	8	0.038
regulation of cardiac chamber formation	GO:1901210	2	0.038
cartilage development involved in endochondral bone morphogenesis	GO:0060351	8	0.037
neural retina development	GO:0003407	49	0.037	Mouse
olfactory bulb development	GO:0021772	4	0.037
hair cell differentiation	GO:0035315	32	0.037	Zebrafish
hematopoietic stem cell differentiation	GO:0060218	20	0.037
pancreatic d cell differentiation	GO:0003311	2	0.037	Zebrafish
negative regulation of metabolic process	GO:0009892	86	0.037	Mouse Fly
nerve development	GO:0021675	45	0.037	Zebrafish
regulation of oocyte development	GO:0060281	3	0.037
spemann organizer formation	GO:0060061	10	0.036
mesenchymal cell differentiation	GO:0048762	87	0.036
canonical wnt signaling pathway	GO:0060070	48	0.036
negative regulation of protein phosphorylation	GO:0001933	4	0.036
negative regulation of cellular biosynthetic process	GO:0031327	55	0.036	Mouse Fly
embryonic hemopoiesis	GO:0035162	53	0.036
single organism nuclear import	GO:1902593	3	0.036
negative regulation of gastrulation	GO:2000542	11	0.036
endochondral bone growth	GO:0003416	2	0.035
female sex differentiation	GO:0046660	4	0.035	Mouse
cell fate specification involved in pattern specification	GO:0060573	3	0.035
nuclear transport	GO:0051169	4	0.035
epithelial to mesenchymal transition	GO:0001837	21	0.035
peripheral nervous system development	GO:0007422	55	0.035	Zebrafish
morphogenesis of embryonic epithelium	GO:0016331	30	0.035	Zebrafish
neuroblast proliferation	GO:0007405	2	0.035
negative regulation of macromolecule metabolic process	GO:0010605	76	0.035	Mouse Fly
erythrocyte differentiation	GO:0030218	54	0.035
positive regulation of neural precursor cell proliferation	GO:2000179	1	0.035	Mouse
phosphorylation	GO:0016310	69	0.034
positive regulation of signaling	GO:0023056	56	0.034
regulation of cell cycle	GO:0051726	52	0.034
regulation of system process	GO:0044057	40	0.034	Zebrafish
convergent extension involved in gastrulation	GO:0060027	71	0.034
regulation of cellular protein metabolic process	GO:0032268	52	0.034
lateral line nerve development	GO:0048892	9	0.034
secondary metabolic process	GO:0019748	3	0.034
negative regulation of rna biosynthetic process	GO:1902679	45	0.033	Mouse Fly
nephron morphogenesis	GO:0072028	2	0.033	Mouse Rat
mediolateral intercalation	GO:0060031	3	0.033
posterior lateral line system development	GO:0048915	46	0.033
muscle fiber development	GO:0048747	52	0.033
organelle organization	GO:0006996	227	0.033
single organism localization	GO:1902578	225	0.033
endothelial cell differentiation	GO:0045446	20	0.033
negative regulation of anterior neural cell fate commitment of the neural plate by wnt signaling pathway	GO:0022002	1	0.033
heart contraction	GO:0060047	71	0.032	Zebrafish
maintenance of location	GO:0051235	4	0.032
gall bladder development	GO:0061010	1	0.032
posterior lateral line neuromast hair cell differentiation	GO:0048923	8	0.031
regulation of cell size	GO:0008361	29	0.031
pons development	GO:0021548	11	0.031
neuroblast differentiation	GO:0014016	1	0.031
defense response to other organism	GO:0098542	33	0.031
kidney development	GO:0001822	92	0.031	Zebrafish Mouse Rat
aorta morphogenesis	GO:0035909	3	0.031
positive regulation of cell fate commitment	GO:0010455	1	0.031
positive regulation of transport	GO:0051050	2	0.031
regulation of mechanoreceptor differentiation	GO:0045631	1	0.031
protein complex subunit organization	GO:0071822	46	0.031
nuclear import	GO:0051170	3	0.030
ear development	GO:0043583	127	0.030	Zebrafish
cellular protein modification process	GO:0006464	100	0.030
ventral spinal cord interneuron specification	GO:0021521	3	0.030
retinal ganglion cell axon guidance	GO:0031290	35	0.030	Zebrafish
regulation of anterior head development	GO:2000742	2	0.030	Mouse
artery development	GO:0060840	22	0.030
positive regulation of endothelial cell differentiation	GO:0045603	2	0.029
peripheral nervous system neuron differentiation	GO:0048934	28	0.029	Zebrafish
spinal cord development	GO:0021510	46	0.029	Zebrafish Mouse
pectoral fin development	GO:0033339	50	0.029
oligodendrocyte cell fate commitment	GO:0021779	5	0.029
homeostatic process	GO:0042592	142	0.029
negative regulation of transcription from rna polymerase ii promoter	GO:0000122	16	0.028
positive regulation of cell communication	GO:0010647	56	0.028
appendage development	GO:0048736	80	0.028	Fly
renal system development	GO:0072001	94	0.028	Zebrafish Mouse Rat
pharyngeal system development	GO:0060037	18	0.028
notch signaling pathway	GO:0007219	35	0.028
midbrain hindbrain boundary development	GO:0030917	23	0.027	Zebrafish
outflow tract morphogenesis	GO:0003151	1	0.027
regulation of cell differentiation	GO:0045595	142	0.027	Mouse Worm
regulation of endothelial cell differentiation	GO:0045601	3	0.027
negative regulation of nucleic acid templated transcription	GO:1903507	45	0.027	Mouse Fly
specification of organ identity	GO:0010092	2	0.027
fourth ventricle development	GO:0021592	8	0.027	Zebrafish
regulation of binding	GO:0051098	3	0.027
cytoskeleton organization	GO:0007010	96	0.027
cardiac chamber morphogenesis	GO:0003206	12	0.027
regulation of axon extension	GO:0030516	24	0.027
retina morphogenesis in camera type eye	GO:0060042	79	0.027	Mouse
establishment of localization	GO:0051234	244	0.027
regulation of multicellular organism growth	GO:0040014	4	0.027
organ growth	GO:0035265	12	0.027
regulation of cytokine production	GO:0001817	3	0.027
negative regulation of anterior neural cell fate commitment of the neural plate	GO:0022001	1	0.027
circulatory system process	GO:0003013	87	0.027	Zebrafish
regulation of organ morphogenesis	GO:2000027	35	0.027	Mouse
segment specification	GO:0007379	12	0.027
rhombomere 5 development	GO:0021571	4	0.026
otic vesicle development	GO:0071599	42	0.026
response to axon injury	GO:0048678	14	0.026
skin development	GO:0043588	54	0.026	Zebrafish
pathway restricted smad protein phosphorylation	GO:0060389	1	0.026
regulation of cell activation	GO:0050865	1	0.026
regulation of nervous system development	GO:0051960	90	0.026	Mouse
cellular ketone metabolic process	GO:0042180	11	0.026
gastrulation with mouth forming second	GO:0001702	44	0.025	Mouse
negative regulation of neurogenesis	GO:0050768	20	0.025
stem cell division	GO:0017145	1	0.025

lhx1b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease	DO term ID	Probability
disease of anatomical entity	DOID:7	0.189
nervous system disease	DOID:863	0.038
eye and adnexa disease	DOID:1492	0.038
sensory system disease	DOID:0050155	0.038
brain disease	DOID:936	0.027
central nervous system disease	DOID:331	0.027
eye disease	DOID:5614	0.025

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