Danio rerio

17 known processes

lepa

leptin a

(Aliases: lep,si:dkey-98o11.2,ob,ob-a)

lepa biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
signal transductionGO:00071654550.107
larval developmentGO:000216420.107
cellular nitrogen compound metabolic processGO:00346412900.097
embryonic organ developmentGO:00485683810.094
nitrogen compound metabolic processGO:00068073190.078
cellular biosynthetic processGO:00442492860.076
organic substance biosynthetic processGO:19015762890.071
heterocycle metabolic processGO:00464832900.071
cellular macromolecule metabolic processGO:00442603910.070
embryonic heart tube morphogenesisGO:00031431080.068
regulation of metabolic processGO:00192223590.067
negative regulation of cellular processGO:00485232830.066
organic cyclic compound metabolic processGO:19013603010.064
central nervous system developmentGO:00074173870.064
regionalizationGO:00030022740.063
regulation of establishment of protein localizationGO:007020140.062
generation of neuronsGO:00486993850.061
regulation of cellular metabolic processGO:00313233200.060
heterocycle biosynthetic processGO:00181302150.059
connective tissue developmentGO:0061448990.059
aromatic compound biosynthetic processGO:00194382170.058
biosynthetic processGO:00090582940.057
nucleic acid metabolic processGO:00903042440.055
cellular amine metabolic processGO:004410620.054
vasculature developmentGO:00019442780.053
small molecule metabolic processGO:0044281770.052
negative regulation of biological processGO:00485193040.052
determination of left right symmetryGO:00073681790.052
response to stressGO:00069502630.051
regulation of primary metabolic processGO:00800903110.049
maintenance of locationGO:005123540.049
determination of bilateral symmetryGO:00098552040.048
hemopoiesisGO:00300971830.047
regulation of signalingGO:00230512350.047
heart developmentGO:00075073130.047
embryonic organ morphogenesisGO:00485622740.047
agingGO:000756820.046
nucleobase containing compound biosynthetic processGO:00346542050.046
cellular response to external stimulusGO:007149620.046
cellular nitrogen compound biosynthetic processGO:00442712180.046
regulation of cellular amine metabolic processGO:003323800.046
regulation of rna biosynthetic processGO:20011412130.045
phosphorus metabolic processGO:00067931090.045
single organism nuclear importGO:190259330.045
regulation of protein transportGO:005122330.044
gland developmentGO:00487321430.043
amine metabolic processGO:000930820.043
protein targeting to nucleusGO:004474430.043
oxoacid metabolic processGO:0043436310.042
cellular carbohydrate metabolic processGO:004426240.042
regulation of cellular amino acid metabolic processGO:000652100.042
positive regulation of cellular processGO:00485222010.042
regulation of multicellular organism growthGO:004001440.041
specification of symmetryGO:00097992040.041
regulation of biological qualityGO:00650082630.041
regulation of signal transductionGO:00099662250.041
positive regulation of transportGO:005105020.040
organic cyclic compound biosynthetic processGO:19013622230.040
lateral line developmentGO:0048882660.040
regulation of biosynthetic processGO:00098892500.040
cartilage developmentGO:0051216960.040
regulation of nitrogen compound metabolic processGO:00511712510.040
nucleobase containing compound metabolic processGO:00061392740.040
nucleocytoplasmic transportGO:000691340.040
establishment of protein localization to organelleGO:007259440.039
neuron developmentGO:00486662620.039
lipid storageGO:001991510.039
positive regulation of cellular amino acid metabolic processGO:004576400.038
camera type eye developmentGO:00430102220.038
protein importGO:001703830.038
multicellular organism growthGO:003526440.037
regulation of reactive oxygen species metabolic processGO:200037720.037
regulation of macromolecule biosynthetic processGO:00105562250.037
cell surface receptor signaling pathwayGO:00071663250.037
negative regulation of protein phosphorylationGO:000193340.036
blood vessel developmentGO:00015682460.036
intracellular signal transductionGO:0035556850.036
homeostatic processGO:00425921420.036
transcription dna templatedGO:00063511810.036
regulation of nucleocytoplasmic transportGO:004682220.036
positive regulation of biological processGO:00485182530.035
nuclear transportGO:005116940.035
regulation of cell communicationGO:00106462320.035
morphogenesis of an epitheliumGO:00020093330.035
cognitionGO:005089010.035
gastrulationGO:00073692080.035
calcium ion transport into cytosolGO:006040230.034
regulation of intracellular protein transportGO:003315730.034
regulation of circadian rhythmGO:004275240.034
heart loopingGO:0001947940.034
regulation of protein targetingGO:190353320.033
organonitrogen compound metabolic processGO:1901564740.033
regulation of protein localization to nucleusGO:190018020.033
cellular response to nutrient levelsGO:003166920.033
cellular macromolecule biosynthetic processGO:00346452240.033
rna metabolic processGO:00160702190.033
heart morphogenesisGO:00030071560.033
negative regulation of protein kinase activityGO:000646940.033
determination of heart left right asymmetryGO:00613711170.033
liver developmentGO:0001889960.033
gene expressionGO:00104672520.033
regulation of macromolecule metabolic processGO:00602553170.032
cellular aromatic compound metabolic processGO:00067252950.032
cellular response to chemical stimulusGO:00708871570.032
regulation of cellular macromolecule biosynthetic processGO:20001122220.031
organic acid metabolic processGO:0006082310.031
regulation of metal ion transportGO:001095940.031
nuclear importGO:005117030.031
retina morphogenesis in camera type eyeGO:0060042790.031
regulation of nucleobase containing compound metabolic processGO:00192192500.031
rna biosynthetic processGO:00327741810.031
i kappab kinase nf kappab signalingGO:000724940.031
regulation of jak stat cascadeGO:004642530.030
regulation of nucleic acid templated transcriptionGO:19035062130.030
phosphate containing compound metabolic processGO:00067961080.030
positive regulation of stress activated protein kinase signaling cascadeGO:007030430.030
cell projection organizationGO:00300302840.030
neuron differentiationGO:00301823530.029
segmentationGO:0035282970.029
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.029
regulation of peptidyl tyrosine phosphorylationGO:005073010.029
regulation of rna metabolic processGO:00512522240.029
tube morphogenesisGO:00352393490.029
nucleic acid templated transcriptionGO:00976591810.029
regulation of cellular ketone metabolic processGO:001056570.029
muscle structure developmentGO:00610611960.029
response to external stimulusGO:00096052640.029
dorsal ventral pattern formationGO:00099531250.028
cellular ketone metabolic processGO:0042180110.028
skeletal system developmentGO:00015011810.028
retina development in camera type eyeGO:00600411460.028
regulation of gene expressionGO:00104682650.028
eye morphogenesisGO:00485921440.027
positive regulation of cellular amine metabolic processGO:003324000.027
protein import into nucleusGO:000660630.027
epithelial cell differentiationGO:00308551160.027
negative regulation of kinase activityGO:003367340.027
epiboly involved in gastrulation with mouth forming secondGO:0055113350.026
female sex differentiationGO:004666040.026
regulation of cytoplasmic transportGO:190364940.026
regulation of response to stimulusGO:00485832690.026
energy reserve metabolic processGO:000611220.026
protein localization to nucleusGO:003450430.026
single organism metabolic processGO:00447102170.026
regulation of bindingGO:005109830.026
somite developmentGO:0061053960.026
positive regulation of stress activated mapk cascadeGO:003287430.026
cellular response to extracellular stimulusGO:003166820.025
superoxide metabolic processGO:000680120.025
phagocytosisGO:000690930.025
neuron projection developmentGO:00311751800.025
sensory system developmentGO:0048880760.025
embryonic heart tube developmentGO:00350501330.025
protein modification processGO:00362111000.025
hematopoietic or lymphoid organ developmentGO:00485341910.025
carboxylic acid metabolic processGO:0019752220.025
regulation of protein catabolic processGO:004217610.025
positive regulation of cell cycleGO:004578730.025
regulation of cytokine productionGO:000181730.025
deathGO:00162651210.025
immune system developmentGO:00025201910.025
germ line stem cell maintenanceGO:003071820.024
cell part morphogenesisGO:00329902460.024
protein metabolic processGO:00195381830.024
cell morphogenesisGO:00009022890.024
sensory organ morphogenesisGO:00905962000.024
cell projection morphogenesisGO:00488582440.024
regulation of cellular biosynthetic processGO:00313262450.024
macromolecule biosynthetic processGO:00090592270.024
long chain fatty acid metabolic processGO:000167610.024
sensory organ developmentGO:00074233930.024
regenerationGO:0031099910.023
cellular response to molecule of bacterial originGO:007121930.023
response to organic substanceGO:00100331530.023
regulation of multicellular organismal processGO:00512392770.023
regulation of protein import into nucleusGO:004230620.023
somatic muscle developmentGO:000752540.023
lateral line system developmentGO:0048925760.023
brain developmentGO:00074202930.023
positive regulation of map kinase activityGO:004340630.022
response to glucocorticoidGO:005138410.022
epibolyGO:0090504410.022
reactive oxygen species biosynthetic processGO:190340910.022
stem cell maintenanceGO:001982740.022
neuromast developmentGO:0048884460.022
positive regulation of cytosolic calcium ion concentrationGO:000720440.022
head developmentGO:00603223030.022
single organism localizationGO:19025782250.022
positive regulation of erk1 and erk2 cascadeGO:007037420.022
negative regulation of macromolecule metabolic processGO:0010605760.022
metal ion transportGO:0030001580.021
wnt signaling pathwayGO:0016055800.021
response to xenobiotic stimulusGO:0009410450.021
negative regulation of protein transportGO:005122430.021
digestive tract developmentGO:00485652650.021
regulation of synaptic plasticityGO:004816710.021
regulation of phosphorus metabolic processGO:0051174430.021
cellular protein metabolic processGO:00442671290.021
regulation of programmed cell deathGO:00430671010.021
small gtpase mediated signal transductionGO:000726480.021
positive regulation of dna metabolic processGO:005105410.021
positive regulation of cytokine productionGO:000181920.021
regulation of multicellular organismal developmentGO:20000262230.021
response to chemicalGO:00422213200.021
regulation of cellular carbohydrate metabolic processGO:001067540.021
negative regulation of catabolic processGO:000989530.021
regulation of calcium ion transportGO:005192420.021
regulation of epithelial cell proliferationGO:005067830.021
somitogenesisGO:0001756870.020
cellular response to biotic stimulusGO:007121630.020
regulation of dendrite developmentGO:005077330.020
cellular response to starvationGO:000926710.020
positive regulation of jnk cascadeGO:004633030.020
hormone biosynthetic processGO:004244630.020
system processGO:00030081850.020
autophagyGO:000691440.020
erk1 and erk2 cascadeGO:007037140.020
cell morphogenesis involved in differentiationGO:00009041950.020
cilium morphogenesisGO:0060271850.020
regulation of transcription dna templatedGO:00063552130.020
positive regulation of i kappab kinase nf kappab signalingGO:004312330.020
cellular amino acid metabolic processGO:000652070.020
reactive oxygen species metabolic processGO:007259360.020
regulation of molecular functionGO:0065009700.019
regulation of erk1 and erk2 cascadeGO:007037240.019
establishment of endothelial barrierGO:006102830.019
regulation of response to nutrient levelsGO:003210710.019
response to nutrientGO:000758430.019
protein secretionGO:000930610.019
response to biotic stimulusGO:0009607970.019
phosphorylationGO:0016310690.019
response to woundingGO:00096111160.019
endocrine system developmentGO:0035270650.019
cellular response to endogenous stimulusGO:0071495680.019
peptidyl serine modificationGO:001820920.019
epithelial tube morphogenesisGO:00605621480.019
regulation of apoptotic processGO:0042981980.019
positive regulation of metabolic processGO:00098931080.019
negative regulation of defense responseGO:003134820.019
regulation of protein complex assemblyGO:004325430.019
positive regulation of catabolic processGO:000989640.019
calcium ion homeostasisGO:0055074190.019
regulation of carbohydrate metabolic processGO:000610940.019
establishment of localizationGO:00512342440.019
cellular response to organic substanceGO:00713101050.018
regulation of i kappab kinase nf kappab signalingGO:004312240.018
cellular response to xenobiotic stimulusGO:0071466350.018
cellular amide metabolic processGO:004360340.018
gastrulation with mouth forming secondGO:0001702440.018
hepaticobiliary system developmentGO:0061008980.018
macroautophagyGO:001623610.018
regulation of intracellular signal transductionGO:1902531570.018
response to endogenous stimulusGO:0009719830.018
cytosolic calcium ion transportGO:006040130.018
camera type eye morphogenesisGO:00485931080.018
xenobiotic metabolic processGO:000680540.018
negative regulation of nitrogen compound metabolic processGO:0051172590.018
regulation of sequestering of calcium ionGO:005128240.018
exocytosisGO:000688710.018
carbohydrate homeostasisGO:003350010.017
transcription from rna polymerase ii promoterGO:0006366800.017
digestive tract morphogenesisGO:00485462310.017
positive regulation of cellular component biogenesisGO:004408930.017
cellular protein modification processGO:00064641000.017
cell migrationGO:00164772370.017
divalent inorganic cation homeostasisGO:0072507220.017
positive regulation of cellular metabolic processGO:0031325940.017
cellular component morphogenesisGO:00329893360.017
positive regulation of signal transductionGO:0009967560.017
mitochondrion organizationGO:000700540.017
b cell activationGO:004211320.017
g protein coupled receptor signaling pathwayGO:0007186740.017
macromolecule modificationGO:00434121110.017
negative regulation of protein import into nucleusGO:004230820.017
response to other organismGO:0051707970.017
regulation of response to biotic stimulusGO:000283120.017
negative regulation of metabolic processGO:0009892860.017
proteolysis involved in cellular protein catabolic processGO:005160330.016
symbiosis encompassing mutualism through parasitismGO:004440340.016
cytokinesisGO:000091030.016
inner ear developmentGO:00488391260.016
localization of cellGO:00516742440.016
hormone mediated signaling pathwayGO:000975590.016
chordate embryonic developmentGO:00430092710.016
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.016
cellular component biogenesisGO:00440851780.016
female gonad developmentGO:000858540.016
programmed cell deathGO:00125011190.016
positive regulation of nitrogen compound metabolic processGO:0051173690.016
positive regulation of secretionGO:005104710.016
cell motilityGO:00488702440.016
heart contractionGO:0060047710.016
positive regulation of immune effector processGO:000269930.016
nitric oxide biosynthetic processGO:000680920.016
negative regulation of gene expressionGO:0010629650.016
cell substrate adhesionGO:003158940.015
regulation of dna replicationGO:000627530.015
peptidyl serine phosphorylationGO:001810510.015
apoptotic processGO:00069151160.015
interspecies interaction between organismsGO:004441940.015
regulation of cell activationGO:005086510.015
adult behaviorGO:003053420.015
regulation of inflammatory responseGO:005072720.015
sequestering of calcium ionGO:005120830.015
gtp metabolic processGO:004603940.015
negative regulation of mitosisGO:004583930.015
negative regulation of nuclear divisionGO:005178430.015
regulation of response to extracellular stimulusGO:003210410.015
metal ion homeostasisGO:0055065260.015
regulation of developmental processGO:00507932470.015
response to monosaccharideGO:003428430.015
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.015
blood vessel morphogenesisGO:00485142160.015
estrogen metabolic processGO:000821020.015
negative regulation of cellular catabolic processGO:003133030.015
development of primary female sexual characteristicsGO:004654540.015
positive regulation of response to stimulusGO:0048584800.015
modification dependent protein catabolic processGO:001994130.015
positive regulation of cellular catabolic processGO:003133130.014
cell deathGO:00082191210.014
reactive nitrogen species metabolic processGO:200105700.014
negative regulation of intracellular protein transportGO:009031730.014
tissue remodelingGO:004877140.014
regulation of tube sizeGO:003515020.014
production of molecular mediator of immune responseGO:000244020.014
regulation of cell deathGO:00109411030.014
sequestering of metal ionGO:005123830.014
positive regulation of neuron deathGO:190121610.014
stem cell divisionGO:001714510.014
inner ear morphogenesisGO:0042472630.014
embryonic pectoral fin morphogenesisGO:0035118240.014
embryonic cranial skeleton morphogenesisGO:0048701900.014
developmental growthGO:00485891660.014
embryonic limb morphogenesisGO:003032620.014
positive regulation of epithelial cell proliferationGO:005067910.014
notochord developmentGO:0030903540.014
response to hexoseGO:000974630.014
appendage developmentGO:0048736800.014
negative regulation of cell deathGO:0060548600.014
multi organism processGO:00517041340.014
pancreas developmentGO:0031016840.014
positive regulation of cell killingGO:003134320.014
cellular component disassemblyGO:002241110.014
fin developmentGO:0033333770.014
mesenchymal cell developmentGO:0014031780.014
regulation of phosphate metabolic processGO:0019220430.013
peptide transportGO:001583310.013
regulation of muscle contractionGO:000693730.013
eye developmentGO:00016542770.013
modification dependent macromolecule catabolic processGO:004363230.013
long chain fatty acid transportGO:001590910.013
neuron projection morphogenesisGO:00488121610.013
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.013
stem cell proliferationGO:007208940.013
regulation of protein metabolic processGO:0051246560.013
synaptic vesicle localizationGO:009747910.013
negative regulation of cellular metabolic processGO:0031324770.013
regulation of transcription from rna polymerase ii promoterGO:00063571140.013
response to corticosteroidGO:003196010.013
alcohol biosynthetic processGO:004616520.013
single organism biosynthetic processGO:0044711710.013
regulation of cell developmentGO:00602841000.013
extrinsic apoptotic signaling pathwayGO:009719130.013
positive regulation of macromolecule metabolic processGO:0010604930.013
regulation of production of molecular mediator of immune responseGO:000270010.013
response to carbohydrateGO:000974330.013
morphogenesis of an epithelial sheetGO:0002011490.013
actin mediated cell contractionGO:007025210.013
negative regulation of intracellular transportGO:003238730.013
organonitrogen compound biosynthetic processGO:1901566470.013
positive regulation of striated muscle cell differentiationGO:005115510.013
negative regulation of protein kinase b signalingGO:005189820.013
negative regulation of epithelial cell proliferationGO:005068010.013
ion transportGO:00068111140.013
chemical homeostasisGO:0048878490.013
immune system processGO:00023762410.013
protein phosphorylationGO:0006468470.013
regulation of neurogenesisGO:0050767870.013
gtp catabolic processGO:000618420.013
tyrosine phosphorylation of stat proteinGO:000726010.013
positive regulation of secretion by cellGO:190353210.013
periodic partitioningGO:000736510.012
digestive system developmentGO:00551232890.012
regulation of cellular protein catabolic processGO:190336210.012
positive regulation of leukocyte mediated immunityGO:000270510.012
skin developmentGO:0043588540.012
response to alkaloidGO:004327920.012
response to uvGO:000941130.012
negative regulation of cytoplasmic transportGO:190365020.012
regulation of synapse organizationGO:005080730.012
regulation of catalytic activityGO:0050790550.012
nitric oxide metabolic processGO:004620920.012
antimicrobial humoral responseGO:001973020.012
response to topologically incorrect proteinGO:003596620.012
sleepGO:003043110.012
regulation of blood vessel sizeGO:005088020.012
growthGO:00400071740.012
establishment of synaptic vesicle localizationGO:009748010.012
ubiquitin dependent protein catabolic processGO:000651130.012
embryonic pattern specificationGO:0009880440.012
smooth muscle contractionGO:000693920.012
myeloid cell differentiationGO:0030099860.012
mesenchyme developmentGO:00604851270.012
modification of morphology or physiology of other organismGO:003582140.012
negative regulation of signalingGO:0023057960.012
response to lipidGO:0033993600.012
positive regulation of multi organism processGO:004390230.012
regulation of proteolysis involved in cellular protein catabolic processGO:190305010.012
neurotransmitter transportGO:000683620.012
circulatory system processGO:0003013870.012
regulation of receptor activityGO:001046920.012
ovulation cycle processGO:002260220.012
sensory perception of painGO:001923310.012
cell killingGO:000190620.012
negative regulation of rna metabolic processGO:0051253480.012
regulation of protein ubiquitinationGO:003139630.012
regulation of organ growthGO:004662030.012
fertilizationGO:000956630.012
negative regulation of apoptotic processGO:0043066550.012
response to drugGO:004249330.011
cellular protein catabolic processGO:004425740.011
organelle fusionGO:004828430.011
regulation of protein modification by small protein conjugation or removalGO:190332030.011
cell agingGO:000756920.011
macromolecular complex disassemblyGO:003298410.011
locomotionGO:00400113130.011
regulation of nucleoside metabolic processGO:000911820.011
negative regulation of mapk cascadeGO:004340940.011
response to bacteriumGO:0009617580.011
positive regulation of cell activationGO:005086710.011
establishment of protein localization to plasma membraneGO:009000210.011
skeletal system morphogenesisGO:00487051020.011
morphogenesis of an epithelial foldGO:006057110.011
lipid catabolic processGO:001604240.011
regulation of heart contractionGO:0008016320.011
carbon dioxide transportGO:001567030.011
determination of dorsal ventral asymmetryGO:0048262340.011
ribonucleotide biosynthetic processGO:0009260200.011
guanosine containing compound catabolic processGO:190106920.011
regulation of transporter activityGO:003240920.011
action potentialGO:0001508190.011
carbohydrate biosynthetic processGO:001605110.011
synaptic growth at neuromuscular junctionGO:005112420.011
glucose importGO:004632320.011
hindbrain developmentGO:0030902910.011
negative regulation of multi organism processGO:004390130.011
response to vitaminGO:003327330.011
wound healingGO:0042060900.011
cell matrix adhesionGO:000716040.011
convergent extensionGO:00600261180.011
carbohydrate derivative biosynthetic processGO:1901137430.011
positive regulation of neuron apoptotic processGO:004352510.011
nucleoside phosphate biosynthetic processGO:1901293210.011
negative regulation of molecular functionGO:0044092230.011
embryonic skeletal system developmentGO:0048706970.011
lipid metabolic processGO:0006629520.011
membrane invaginationGO:001032410.011
negative regulation of cellular macromolecule biosynthetic processGO:2000113480.011
regulation of cell substrate adhesionGO:001081010.011
anterior posterior pattern specificationGO:00099521520.011
otic vesicle developmentGO:0071599420.011
negative regulation of immune responseGO:005077720.011
regulation of reproductive processGO:200024140.011
negative regulation of nucleobase containing compound metabolic processGO:0045934590.011
regulation of autophagyGO:001050630.011
regulation of response to oxidative stressGO:190288220.010
regulation of purine nucleotide catabolic processGO:003312120.010
mitotic dna integrity checkpointGO:004477440.010
regulation of cardiac muscle contractionGO:005511720.010
insulin like growth factor receptor signaling pathwayGO:004800940.010
single organism organelle organizationGO:19025891990.010
urogenital system developmentGO:0001655970.010
protein kinase b signalingGO:004349190.010
activation of mapk activityGO:000018730.010
fat soluble vitamin metabolic processGO:000677540.010
positive regulation of neural precursor cell proliferationGO:200017910.010
synaptic target recognitionGO:000803910.010
regulation of phosphorylationGO:0042325260.010
cellular response to growth factor stimulusGO:0071363390.010
regulation of cell differentiationGO:00455951420.010
response to hormoneGO:0009725480.010
cell morphogenesis involved in neuron differentiationGO:00486671630.010
proteasomal protein catabolic processGO:001049820.010
cardiac muscle cell contractionGO:008600310.010
heart processGO:0003015710.010

lepa disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.032
nervous system diseaseDOID:86300.024
disease of cellular proliferationDOID:1456600.017
disease of metabolismDOID:001466700.017
inherited metabolic disorderDOID:65500.017
eye and adnexa diseaseDOID:149200.015
sensory system diseaseDOID:005015500.015
eye diseaseDOID:561400.014
cancerDOID:16200.014
retinal diseaseDOID:567900.012
organ system cancerDOID:005068600.011