Danio rerio

7 known processes

lepb

leptin b

(Aliases: si:dkey-21o22.1)

lepb biological process predictions


Filter by process size:
Biological processGO term IDProcess sizeProbabilityFunc Analog Org
larval developmentGO:000216420.116
cell surface receptor signaling pathwayGO:00071663250.088
agingGO:000756820.075
signal transductionGO:00071654550.075
regulation of signalingGO:00230512350.055
cellular nitrogen compound metabolic processGO:00346412900.053
lipid storageGO:001991510.053
regulation of multicellular organism growthGO:004001440.050
regulation of multicellular organismal processGO:00512392770.050
nitrogen compound metabolic processGO:00068073190.050
heterocycle biosynthetic processGO:00181302150.049
maintenance of locationGO:005123540.049
positive regulation of transportGO:005105020.046
female sex differentiationGO:004666040.044
cellular nitrogen compound biosynthetic processGO:00442712180.044
regulation of cell communicationGO:00106462320.042
regulation of signal transductionGO:00099662250.042
response to biotic stimulusGO:0009607970.042
regulation of cellular metabolic processGO:00313233200.042
cellular biosynthetic processGO:00442492860.041
response to external stimulusGO:00096052640.041
blood vessel developmentGO:00015682460.041
regulation of response to stimulusGO:00485832690.041
cellular amine metabolic processGO:004410620.040
g protein coupled receptor signaling pathwayGO:0007186740.040
response to other organismGO:0051707970.040
establishment of protein localization to organelleGO:007259440.040
heterocycle metabolic processGO:00464832900.040
response to nutrientGO:000758430.039
regulation of cellular amino acid metabolic processGO:000652100.039
cellular macromolecule metabolic processGO:00442603910.039
stem cell proliferationGO:007208940.038
positive regulation of myeloid cell differentiationGO:004563920.038
cellular response to external stimulusGO:007149620.037
organic substance biosynthetic processGO:19015762890.037
rna biosynthetic processGO:00327741810.037
aromatic compound biosynthetic processGO:00194382170.036
vasculature developmentGO:00019442780.036
regulation of biological qualityGO:00650082630.036
amine metabolic processGO:000930820.036
blood vessel morphogenesisGO:00485142160.036
regulation of cell activationGO:005086510.035
response to external biotic stimulusGO:0043207970.035
cellular ketone metabolic processGO:0042180110.035
single organism metabolic processGO:00447102170.035
cellular macromolecule biosynthetic processGO:00346452240.034
regulation of inflammatory responseGO:005072720.034
regulation of response to nutrient levelsGO:003210710.033
multicellular organism growthGO:003526440.033
regulation of cellular amine metabolic processGO:003323800.033
tissue remodelingGO:004877140.033
positive regulation of catabolic processGO:000989640.032
response to stressGO:00069502630.032
positive regulation of cytokine productionGO:000181920.032
regulation of metabolic processGO:00192223590.032
cellular response to nutrient levelsGO:003166920.032
regulation of primary metabolic processGO:00800903110.032
regulation of cellular ketone metabolic processGO:001056570.032
cellular response to chemical stimulusGO:00708871570.032
rna metabolic processGO:00160702190.031
regulation of cytokine productionGO:000181730.031
cellular aromatic compound metabolic processGO:00067252950.031
development of primary female sexual characteristicsGO:004654540.031
biosynthetic processGO:00090582940.031
oxoacid metabolic processGO:0043436310.031
small molecule metabolic processGO:0044281770.030
phagocytosisGO:000690930.030
regulation of protein transportGO:005122330.030
female gonad developmentGO:000858540.030
positive regulation of nitrogen compound metabolic processGO:0051173690.030
cellular response to molecule of bacterial originGO:007121930.030
nucleic acid metabolic processGO:00903042440.030
mitochondrion organizationGO:000700540.029
regulation of peptidyl tyrosine phosphorylationGO:005073010.029
regulation of transcription dna templatedGO:00063552130.029
regulation of rna biosynthetic processGO:20011412130.028
regulation of response to extracellular stimulusGO:003210410.028
embryonic organ developmentGO:00485683810.028
energy reserve metabolic processGO:000611220.028
transcription dna templatedGO:00063511810.028
phospholipase c activating g protein coupled receptor signaling pathwayGO:000720020.028
positive regulation of cellular amino acid metabolic processGO:004576400.028
organonitrogen compound metabolic processGO:1901564740.028
response to topologically incorrect proteinGO:003596620.028
response to organic substanceGO:00100331530.028
positive regulation of biological processGO:00485182530.028
response to bacteriumGO:0009617580.028
cellular carbohydrate metabolic processGO:004426240.028
response to drugGO:004249330.028
carboxylic acid metabolic processGO:0019752220.027
cellular amino acid metabolic processGO:000652070.027
cellular response to lipopolysaccharideGO:007122230.027
positive regulation of cell cycleGO:004578730.027
negative regulation of biological processGO:00485193040.027
muscle structure developmentGO:00610611960.027
regulation of nucleobase containing compound metabolic processGO:00192192500.026
organic acid metabolic processGO:0006082310.026
central nervous system developmentGO:00074173870.026
regulation of macromolecule metabolic processGO:00602553170.026
macromolecule biosynthetic processGO:00090592270.026
nuclear transportGO:005116940.026
nucleobase containing compound biosynthetic processGO:00346542050.026
cellular component morphogenesisGO:00329893360.026
response to chemicalGO:00422213200.026
cellular response to extracellular stimulusGO:003166820.026
organic cyclic compound biosynthetic processGO:19013622230.026
negative regulation of cellular processGO:00485232830.026
b cell activationGO:004211320.026
regulation of gene expressionGO:00104682650.026
regulation of multicellular organismal developmentGO:20000262230.025
single organism nuclear importGO:190259330.025
transcription from rna polymerase ii promoterGO:0006366800.025
regulation of metal ion transportGO:001095940.025
regulation of reactive oxygen species metabolic processGO:200037720.025
positive regulation of cellular amine metabolic processGO:003324000.025
nucleic acid templated transcriptionGO:00976591810.025
sleepGO:003043110.025
cellular response to biotic stimulusGO:007121630.024
stem cell maintenanceGO:001982740.024
regulation of rna metabolic processGO:00512522240.024
morphogenesis of an epitheliumGO:00020093330.024
regulation of biosynthetic processGO:00098892500.024
negative regulation of defense responseGO:003134820.024
positive regulation of cellular catabolic processGO:003133130.024
nuclear importGO:005117030.024
protein targeting to nucleusGO:004474430.024
protein localization to nucleusGO:003450430.024
stem cell divisionGO:001714510.023
immune system developmentGO:00025201910.023
somatic muscle developmentGO:000752540.023
regulation of stem cell proliferationGO:007209120.023
cellular response to starvationGO:000926710.023
positive regulation of immune effector processGO:000269930.023
regulation of developmental processGO:00507932470.023
nucleocytoplasmic transportGO:000691340.023
regulation of production of molecular mediator of immune responseGO:000270010.023
regulation of blood vessel sizeGO:005088020.023
protein importGO:001703830.023
regulation of blood pressureGO:000821710.023
intracellular signal transductionGO:0035556850.023
gene expressionGO:00104672520.022
immune system processGO:00023762410.022
protein import into nucleusGO:000660630.022
chordate embryonic developmentGO:00430092710.022
connective tissue developmentGO:0061448990.022
regulation of i kappab kinase nf kappab signalingGO:004312240.022
regulation of tube sizeGO:003515020.022
organic cyclic compound metabolic processGO:19013603010.022
response to woundingGO:00096111160.021
autophagyGO:000691440.021
reactive oxygen species biosynthetic processGO:190340910.021
positive regulation of cell activationGO:005086710.021
nucleobase containing compound metabolic processGO:00061392740.021
positive regulation of i kappab kinase nf kappab signalingGO:004312330.021
regulation of cellular biosynthetic processGO:00313262450.021
phosphatidylinositol 3 kinase signalingGO:001406520.021
regulation of nucleic acid templated transcriptionGO:19035062130.021
enzyme linked receptor protein signaling pathwayGO:00071671060.020
macroautophagyGO:001623610.020
inositol lipid mediated signalingGO:004801720.020
protein secretionGO:000930610.020
regulation of establishment of protein localizationGO:007020140.020
cell migrationGO:00164772370.020
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domainsGO:000246040.020
eye developmentGO:00016542770.020
positive regulation of lymphocyte mediated immunityGO:000270810.020
determination of bilateral symmetryGO:00098552040.020
cellular response to organic substanceGO:00713101050.020
single fertilizationGO:000733830.020
generation of neuronsGO:00486993850.020
regulation of carbohydrate metabolic processGO:000610940.019
regulation of cellular macromolecule biosynthetic processGO:20001122220.019
adult behaviorGO:003053420.019
angiogenesisGO:00015251580.019
ovulation cycle processGO:002260220.019
brain developmentGO:00074202930.019
negative regulation of protein phosphorylationGO:000193340.019
establishment of localizationGO:00512342440.019
response to vitaminGO:003327330.019
meiotic nuclear divisionGO:000712640.018
phosphatidylinositol mediated signalingGO:004801520.018
leukocyte proliferationGO:007066110.018
mononuclear cell proliferationGO:003294310.018
regulation of neural precursor cell proliferationGO:200017730.018
sensory perception of chemical stimulusGO:000760630.018
regulation of nitrogen compound metabolic processGO:00511712510.018
positive regulation of dna metabolic processGO:005105410.018
regulation of macromolecule biosynthetic processGO:00105562250.018
cellular component movementGO:00069283350.018
ubiquitin dependent protein catabolic processGO:000651130.018
response to monosaccharideGO:003428430.017
alcohol biosynthetic processGO:004616520.017
multi organism processGO:00517041340.017
endocrine processGO:005088620.017
regulation of bindingGO:005109830.017
positive regulation of macromolecule metabolic processGO:0010604930.017
protein acetylationGO:000647320.017
locomotionGO:00400113130.017
sensory perception of painGO:001923310.017
regulation of autophagyGO:001050630.017
smooth muscle contractionGO:000693920.017
er nucleus signaling pathwayGO:000698420.017
immunoglobulin mediated immune responseGO:001606430.017
positive regulation of cytosolic calcium ion concentrationGO:000720440.017
regulation of sodium ion transportGO:000202820.017
proteolysis involved in cellular protein catabolic processGO:005160330.017
cell motilityGO:00488702440.017
positive regulation of map kinase activityGO:004340630.017
neuron neuron synaptic transmissionGO:000727010.017
hemopoiesisGO:00300971830.017
cellular response to radiationGO:007147840.017
response to carbohydrateGO:000974330.017
long chain fatty acid metabolic processGO:000167610.017
gtp metabolic processGO:004603940.017
regulation of protein catabolic processGO:004217610.017
cellular component disassemblyGO:002241110.017
regulation of reproductive processGO:200024140.017
cellular protein catabolic processGO:004425740.017
i kappab kinase nf kappab signalingGO:000724940.017
response to lipidGO:0033993600.017
germ line stem cell maintenanceGO:003071820.017
fatty acid transportGO:001590810.017
regionalizationGO:00030022740.017
ovulation cycleGO:004269820.017
embryonic organ morphogenesisGO:00485622740.017
homeostatic processGO:00425921420.017
guanosine containing compound catabolic processGO:190106920.016
specification of symmetryGO:00097992040.016
chemosensory behaviorGO:000763510.016
regulation of protein complex assemblyGO:004325430.016
tube morphogenesisGO:00352393490.016
response to glucocorticoidGO:005138410.016
modification dependent protein catabolic processGO:001994130.016
regulation of protein modification by small protein conjugation or removalGO:190332030.016
regulation of circadian rhythmGO:004275240.016
response to unfolded proteinGO:000698620.016
lipid catabolic processGO:001604240.016
response to endogenous stimulusGO:0009719830.016
response to ketoneGO:190165410.016
negative regulation of catabolic processGO:000989530.016
response to corticosteroidGO:003196010.016
extrinsic apoptotic signaling pathwayGO:009719130.016
lymphocyte proliferationGO:004665110.016
sex determinationGO:000753010.016
cognitionGO:005089010.016
cell deathGO:00082191210.016
calcium ion transport into cytosolGO:006040230.016
localization of cellGO:00516742440.016
response to xenobiotic stimulusGO:0009410450.016
positive regulation of cellular component biogenesisGO:004408930.016
nitric oxide biosynthetic processGO:000680920.016
positive regulation of cellular processGO:00485222010.016
guanosine containing compound metabolic processGO:190106840.016
regulation of organ growthGO:004662030.016
fertilizationGO:000956630.015
b cell mediated immunityGO:001972430.015
regulation of purine nucleotide catabolic processGO:003312120.015
regulation of synaptic plasticityGO:004816710.015
skeletal system developmentGO:00015011810.015
regulation of nucleotide catabolic processGO:003081120.015
meiotic cell cycle processGO:190304630.015
organelle organizationGO:00069962270.015
hematopoietic or lymphoid organ developmentGO:00485341910.015
positive regulation of secretionGO:005104710.015
regulation of jak stat cascadeGO:004642530.015
regulation of epithelial cell proliferationGO:005067830.015
production of molecular mediator of immune responseGO:000244020.015
positive regulation of response to stimulusGO:0048584800.015
positive regulation of cellular metabolic processGO:0031325940.015
embryonic heart tube developmentGO:00350501330.015
carbohydrate biosynthetic processGO:001605110.015
growthGO:00400071740.015
membrane invaginationGO:001032410.015
apoptotic processGO:00069151160.015
positive regulation of secretion by cellGO:190353210.015
negative regulation of kinase activityGO:003367340.015
regulation of transcription from rna polymerase ii promoterGO:00063571140.015
peptidyl serine modificationGO:001820920.015
hormone biosynthetic processGO:004244630.015
programmed cell deathGO:00125011190.014
regulation of nucleoside metabolic processGO:000911820.014
regulation of synapse assemblyGO:005196330.014
symbiosis encompassing mutualism through parasitismGO:004440340.014
heart morphogenesisGO:00030071560.014
regulation of intracellular protein transportGO:003315730.014
negative regulation of cellular catabolic processGO:003133030.014
regulation of cytoplasmic transportGO:190364940.014
regulation of muscle contractionGO:000693730.014
defense responseGO:0006952470.014
embryo development ending in birth or egg hatchingGO:00097922710.014
gtp catabolic processGO:000618420.014
phagocytosis engulfmentGO:000691110.014
hormone secretionGO:004687920.014
response to hexoseGO:000974630.014
deathGO:00162651210.014
single organism localizationGO:19025782250.014
positive regulation of metabolic processGO:00098931080.014
reactive nitrogen species metabolic processGO:200105700.014
positive regulation of gtp catabolic processGO:003312610.014
striated muscle cell differentiationGO:00511461290.014
regulation of protein import into nucleusGO:004230620.014
negative regulation of protein kinase activityGO:000646940.014
positive regulation of stress activated mapk cascadeGO:003287430.014
myeloid cell differentiationGO:0030099860.013
cellular response to topologically incorrect proteinGO:003596720.013
response to uvGO:000941130.013
head developmentGO:00603223030.013
cellular response to unfolded proteinGO:003462020.013
positive regulation of peptidyl tyrosine phosphorylationGO:005073110.013
ribonucleoside monophosphate catabolic processGO:000915840.013
regulation of hormone secretionGO:004688320.013
atp catabolic processGO:000620040.013
protein homooligomerizationGO:005126030.013
regulation of protein targetingGO:190353320.013
protein metabolic processGO:00195381830.013
inner ear developmentGO:00488391260.013
developmental growthGO:00485891660.013
circadian sleep wake cycleGO:004274520.013
positive regulation of apoptotic signaling pathwayGO:200123510.013
camera type eye developmentGO:00430102220.013
multi organism cellular processGO:004476420.013
membrane fusionGO:006102520.013
positive regulation of nucleotide catabolic processGO:003081310.013
regulation of circadian sleep wake cycleGO:004274910.013
wound healingGO:0042060900.013
regulation of protein localization to nucleusGO:190018020.013
negative regulation of response to stimulusGO:00485851040.013
interspecies interaction between organismsGO:004441940.013
positive regulation of blood circulationGO:190352420.013
positive regulation of nucleoside metabolic processGO:004597910.013
homeostasis of number of cellsGO:0048872620.013
anterior posterior pattern specificationGO:00099521520.013
cell part morphogenesisGO:00329902460.013
regulation of growth rateGO:004000910.013
regulation of gtp catabolic processGO:003312420.013
somatic cell dna recombinationGO:001644410.013
regulation of cellular phGO:003064110.013
heart developmentGO:00075073130.013
mechanosensory behaviorGO:000763820.013
somite developmentGO:0061053960.013
secondary metabolic processGO:001974830.013
glucose importGO:004632320.013
regulation of circadian sleep wake cycle sleepGO:004518710.012
muscle cell differentiationGO:00426921390.012
internal protein amino acid acetylationGO:000647520.012
skeletal muscle tissue developmentGO:0007519670.012
developmental programmed cell deathGO:001062340.012
regulation of protein ubiquitinationGO:003139630.012
macromolecular complex disassemblyGO:003298410.012
somatic stem cell maintenanceGO:003501910.012
epithelial tube morphogenesisGO:00605621480.012
response to amino acidGO:004320020.012
positive regulation of purine nucleotide catabolic processGO:003312310.012
regulation of skeletal muscle tissue developmentGO:004864140.012
peptidyl lysine acetylationGO:001839420.012
positive regulation of gtpase activityGO:004354710.012
positive regulation of endothelial cell proliferationGO:000193810.012
transmembrane receptor protein serine threonine kinase signaling pathwayGO:0007178680.012
compound eye developmentGO:004874920.012
camp biosynthetic processGO:0006171110.012
circulatory system processGO:0003013870.012
extrinsic apoptotic signaling pathway in absence of ligandGO:009719210.012
oocyte maturationGO:000155640.012
peptide transportGO:001583310.012
phosphate containing compound metabolic processGO:00067961080.012
cell projection morphogenesisGO:00488582440.012
digestive tract morphogenesisGO:00485462310.012
internal peptidyl lysine acetylationGO:001839320.012
regulation of transporter activityGO:003240920.012
regulation of erk1 and erk2 cascadeGO:007037240.012
determination of left right symmetryGO:00073681790.012
action potentialGO:0001508190.012
synaptic growth at neuromuscular junctionGO:005112420.012
system processGO:00030081850.012
positive regulation of jak stat cascadeGO:004642720.012
carbohydrate homeostasisGO:003350010.012
multicellular organismal metabolic processGO:004423620.012
insulin like growth factor receptor signaling pathwayGO:004800940.012
regulation of gtpase activityGO:004308720.012
negative regulation of signalingGO:0023057960.012
xenobiotic metabolic processGO:000680540.012
amino acid transportGO:000686520.012
dicarboxylic acid metabolic processGO:004364810.012
regulation of dna templated transcription in response to stressGO:004362000.012
regulation of nucleocytoplasmic transportGO:004682220.012
hormone transportGO:000991420.012
negative regulation of autophagyGO:001050710.012
centrosome organizationGO:005129710.012
regulation of dna recombinationGO:000001820.012
negative regulation of sequence specific dna binding transcription factor activityGO:004343320.012
glucose homeostasisGO:004259310.012
muscle cell developmentGO:00550011150.012
purine ribonucleoside monophosphate catabolic processGO:000916940.012
negative regulation of reproductive processGO:200024230.012
regulation of lyase activityGO:0051339120.012
spinal cord developmentGO:0021510460.012
glial cell proliferationGO:001400940.012
erk1 and erk2 cascadeGO:007037140.012
cellular response to reactive oxygen speciesGO:003461420.011
purine nucleotide biosynthetic processGO:0006164200.011
positive regulation of multi organism processGO:004390230.011
regulation of phGO:000688530.011
response to foodGO:003209410.011
negative regulation of dna metabolic processGO:005105340.011
positive regulation of jnk cascadeGO:004633030.011
cyclic purine nucleotide metabolic processGO:0052652180.011
positive regulation of leukocyte differentiationGO:190210710.011
regulation of glucose transportGO:001082710.011
circadian sleep wake cycle processGO:002241020.011
protein complex disassemblyGO:004324110.011
muscle tissue developmentGO:00605371100.011
purine nucleoside monophosphate catabolic processGO:000912840.011
protein heterooligomerizationGO:005129110.011
cell agingGO:000756920.011
cellular response to endogenous stimulusGO:0071495680.011
positive regulation of cell divisionGO:005178120.011
protein acylationGO:004354330.011
cell morphogenesisGO:00009022890.011
neuroblast proliferationGO:000740520.011
regulation of dendrite developmentGO:005077330.011
nitric oxide metabolic processGO:004620920.011
modification dependent macromolecule catabolic processGO:004363230.011
negative regulation of protein transportGO:005122430.011
positive regulation of inflammatory responseGO:005072910.011
digestive system developmentGO:00551232890.011
long chain fatty acid transportGO:001590910.011
positive regulation of reproductive processGO:200024320.011
positive regulation of epithelial cell proliferationGO:005067910.011
striated muscle tissue developmentGO:00147061100.011
tube closureGO:006060610.011
tyrosine phosphorylation of stat proteinGO:000726010.011
ear developmentGO:00435831270.011
antimicrobial humoral responseGO:001973020.011
immunoglobulin productionGO:000237710.011
negative regulation of immune responseGO:005077720.011
ovarian follicle developmentGO:000154120.011
regulation of transmembrane transporter activityGO:002289820.011
cell projection organizationGO:00300302840.011
negative regulation of nucleocytoplasmic transportGO:004682320.011
regulation of symbiosis encompassing mutualism through parasitismGO:004390310.011
regulation of extrinsic apoptotic signaling pathwayGO:200123630.011
response to glucoseGO:000974930.011
establishment of endothelial barrierGO:006102830.011
positive regulation of nucleic acid templated transcriptionGO:1903508570.011
cellular respirationGO:004533330.011
circadian sleep wake cycle sleepGO:005080210.011
heart loopingGO:0001947940.011
pigmentationGO:0043473850.011
positive regulation of signal transductionGO:0009967560.011
regulation of cellular protein catabolic processGO:190336210.011
regulation of photoreceptor cell differentiationGO:004653220.011
cell proliferationGO:0008283800.011
regulation of leukocyte mediated immunityGO:000270310.011
regulation of lipid transportGO:003236840.011
cellular amide metabolic processGO:004360340.011
sensory organ morphogenesisGO:00905962000.011
ameboidal type cell migrationGO:00016671430.011
nucleoside monophosphate catabolic processGO:000912540.011
positive regulation of macromolecule biosynthetic processGO:0010557590.011
positive regulation of leukocyte mediated immunityGO:000270510.011
sensory organ developmentGO:00074233930.011
cellular response to light stimulusGO:007148240.010
cellular component assembly involved in morphogenesisGO:00109271070.010
neuronal action potentialGO:0019228180.010
single organism biosynthetic processGO:0044711710.010
regulation of calcium ion transportGO:005192420.010
superoxide metabolic processGO:000680120.010
negative regulation of signal transductionGO:0009968940.010
negative regulation of intracellular transportGO:003238730.010
stem cell fate commitmentGO:004886510.010
positive regulation of transcription dna templatedGO:0045893570.010
cellular response to xenobiotic stimulusGO:0071466350.010
negative regulation of multi organism processGO:004390130.010
positive regulation of cytoskeleton organizationGO:005149530.010
regulation of synapse organizationGO:005080730.010
golgi vesicle transportGO:004819330.010
negative regulation of macromolecule metabolic processGO:0010605760.010
positive regulation of cellular carbohydrate metabolic processGO:001067610.010
regulation of response to oxidative stressGO:190288220.010
lipid homeostasisGO:005508830.010
cytokinesisGO:000091030.010
single organism organelle organizationGO:19025891990.010
positive regulation of epithelial cell differentiationGO:003085820.010

lepb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

DiseaseDO term IDSizeProbabilityFunc Analog Org
disease of anatomical entityDOID:700.030
inherited metabolic disorderDOID:65500.017
disease of metabolismDOID:001466700.017
nervous system diseaseDOID:86300.016
musculoskeletal system diseaseDOID:1700.015
eye and adnexa diseaseDOID:149200.014
sensory system diseaseDOID:005015500.014
eye diseaseDOID:561400.014
disease of cellular proliferationDOID:1456600.014
cancerDOID:16200.012
bone diseaseDOID:008000100.011
connective tissue diseaseDOID:6500.011
organ system cancerDOID:005068600.010